JaLCDOI | 10.18926/AMO/53671 |
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FullText URL | 69_5_261.pdf |
Author | Nojima, Daisuke| Fujimoto, Nobukazu| Kato, Katsuya| Fuchimoto, Yasuko| Kiura, Katsuyuki| Kishimoto, Takumi| Tanimoto, Mitsune| |
Abstract | We investigated the clinical features of asbestos-induced diffuse pleural thickening (DPT) with severe respiratory compromise. We conducted a retrospective study of consecutive subjects with asbestos-induced DPT. Medical data such as initial symptoms, radiological findings, respiratory function test results, and clinical course were collected and analyzed. There were 24 patients between 2003 and 2012. All were men, and the median age at the development of DPT was 74 years. The top occupational category associated with asbestos exposure was dockyard workers. The median duration of asbestos exposure was 35.0 years, and the median latency from first exposure to the onset of DPT was 49.0 years. There were no significant differences in respiratory function test results between the higher and lower Brinkman index groups or between unilateral and bilateral DPT. Thirteen patients had a history of benign asbestos pleural effusion (BAPE), and the median duration from pleural fluid accumulation to DPT with severe respiratory compromise was 28.4 months. DPT with severe respiratory compromise can develop after a long latency following occupational asbestos exposure and a history of BAPE. |
Keywords | asbestos pleural thickening MRC dyspnea scale respiratory function test costophrenic angle |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2015-10 |
Volume | volume69 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 261 |
End Page | 266 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 26490022 |
Web of Science KeyUT | 000365519600001 |
JaLCDOI | 10.18926/AMO/32200 |
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FullText URL | fulltext.pdf |
Author | Ohnoshi, Taisuke| Hiraki, Shunkichi| Ueda, Nobuo| Fujii, Masafumi| Machida, Ken-ichi| Ueoka, Hiroshi| Kawahara, Shin| Kozuka, Akira| Kiura, Katsuyuki| Moritaka, Tomonori| Kodani, Tsuyoshi| Kamei, Haruhito| Kimura, Ikuro| |
Abstract | Twenty-seven previously untreated patients with unresectable non-small cell lung cancer were treated with a 3-drug combination of ifosfamide, cisplatin, and vindesine as a phase II study. Patients received ifosfamide, 1.3g/m2, on days 1 to 5; cisplatin, 20mg/m2, on days 1 to 5; and vindesine, 3mg/m2, on days 1 and 8; with a sufficient parenteral hydration. Courses were repeated every 4 weeks. Twenty males and seven females with a median age of 61 years were treated and fully evaluated. Five patients had stage IIIA, seven had stage IIIB, and 15 had stage IV disease. One patient with adenocarcinoma achieved a complete response and 16 achieved a partial response, for an overall response rate of 63% (95% confidence limit: 45% to 81%). The median duration of response was 34 weeks (range: 9 to 52 weeks). The median survival time was 58 weeks for patients with IIIA/B disease, and 33 weeks for those with IV disease. The major toxicity was myelosuppression, however, it was generally well-tolerated. These results indicate that the 3-drug combination is active against non-small cell lung cancer and warrants further clinical trials. |
Keywords | non-small cell lung cancer ifosfamide cisplatin vindesine |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1991-10 |
Volume | volume45 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 357 |
End Page | 361 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 1661559 |
Web of Science KeyUT | A1991GN53800010 |
FullText URL | fulltext20230421-01.pdf figure20230421-01.pdf |
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Author | Nakasuka, Takamasa| Ohashi, Kadoaki| Nishii, Kazuya| Hirabae, Atsuko| Okawa, Sachi| Tomonobu, Nahoko| Takada, Kenji| Ando, Chihiro| Watanabe, Hiromi| Makimoto, Go| Ninomiya, Kiichiro| Fujii, Masanori| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Kumon, Hiromi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | EGFR mutation Non-small cell lung cancer Antitumor immunity Non-inflamed tumor Ad-SGE-REIC Gene therapy PD-1 |
Note | ©2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.lungcan.2023.01.018.| This fulltext file will be available in Apr. 2024.| |
Published Date | 2023-04 |
Publication Title | Lung Cancer |
Volume | volume178 |
Publisher | Elsevier BV |
Start Page | 1 |
End Page | 10 |
ISSN | 0169-5002 |
NCID | AA10785743 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Elsevier B.V. |
File Version | author |
PubMed ID | 36753780 |
DOI | 10.1016/j.lungcan.2023.01.018 |
Web of Science KeyUT | 000931976300001 |
Related Url | isVersionOf https://doi.org/10.1016/j.lungcan.2023.01.018 |
FullText URL | fulltext.pdf |
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Author | Nishii, Kazuya| Inoue, Masaaki| Obata, Hideto| Ueda, Yutaka| Kozuki, Toshiyuki| Yamasaki, Masahiro| Moritaka, Tomonori| Awaya, Yoshikazu| Sugimoto, Keisuke| Gemba, Kenichi| Kuyama, Shoichi| Ichikawa, Hirohisa| Shibayama, Takuo| Kubota, Tetsuya| Kodani, Masahiro| Kishino, Daizo| Fujimoto, Nobukazu| Ishikawa, Nobuhisa| Tsubata, Yukari| Ishii, Tomoya| Fujitaka, Kazunori| Hotta, Katsuyuki| Kiura, Katsuyuki| |
Keywords | Database observational study real world data surveillance treatment |
Published Date | 2021-01-12 |
Publication Title | Thoracic Cancer |
Volume | volume12 |
Issue | issue5 |
Publisher | Wiley |
Start Page | 725 |
End Page | 731 |
ISSN | 1759-7706 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 The Authors. |
File Version | publisher |
PubMed ID | 33434415 |
DOI | 10.1111/1759-7714.13789 |
Web of Science KeyUT | 000606961500001 |
Related Url | isVersionOf https://doi.org/10.1111/1759-7714.13789 |
FullText URL | fulltext.pdf |
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Author | Senoo, Satoru| Miyahara, Nobuaki| Taniguchi, Akihiko| Oda, Naohiro| Itano, Junko| Higo, Hisao| Hara, Naofumi| Watanabe, Hiromi| Kano, Hirohisa| Suwaki, Toshimitsu| Fuchimoto, Yasuko| Kajimoto, Kazuhiro| Ichikawa, Hirohisa| Kudo, Kenichiro| Shibayama, Takuo| Tanimoto, Yasushi| Kuyama, Shoichi| Kanehiro, Arihiko| Maeda, Yoshinobu| Kiura, Katsuyuki| Okayama Respiratory Disease Study Group (ORDSG)| |
Published Date | 2020-08-27 |
Publication Title | PLoS ONE |
Volume | volume15 |
Issue | issue8 |
Publisher | Public Library of Science |
Start Page | e0236935 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Senoo et al. |
File Version | publisher |
PubMed ID | 32853277 |
DOI | 10.1371/journal.pone.0236935 |
Web of Science KeyUT | 000566948800009 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0236935 |
FullText URL | fulltext20221223-3.pdf NA_Itano_Fig.pdf supl20221223-3.pdf NA_Itano_Supl.pdf |
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Author | Itano, Junko| Taniguchi, Akihiko| Senoo, Satoru| Asada, Noboru| Gion, Yuka| Egusa, Yuria| Guo, Lili| Oda, Naohiro| Araki, Kota| Sato, Yasuharu| Toyooka, Shinichi| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
Keywords | idiopathic pulmonary fibrosis NPY IL-1 beta; bleomycin bronchial epithelial cells |
Note | Originally Published in:Itano J, Taniguchi A, Senoo S, Asada N, Gion Y, Egusa Y, Guo L, Oda N, Araki K, Sato Y, Toyooka S, Kiura K, Maeda Y, Miyahara N. Neuropeptide Y Antagonizes Development of Pulmonary Fibrosis through IL-1β Inhibition. Am J Respir Cell Mol Biol. 2022 Dec;67(6):654-665. DOI: 10.1165/rcmb.2021-0542OC Copyright © 2022 by the American Thoracic Society The final publication is available at https://doi.org/10.1165/rcmb.2021-0542OC | This full-text will be available in Dec. 2023.| |
Published Date | 2022-12 |
Publication Title | American Journal of Respiratory Cell and Molecular Biology |
Volume | volume67 |
Issue | issue6 |
Publisher | American Thoracic Society |
Start Page | 654 |
End Page | 665 |
ISSN | 1044-1549 |
NCID | AA10707251 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 by the American Thoracic Society |
File Version | author |
PubMed ID | 36122332 |
DOI | 10.1165/rcmb.2021-0542oc |
Web of Science KeyUT | 000891796900010 |
Related Url | isVersionOf https://doi.org/10.1165/rcmb.2021-0542oc |
JaLCDOI | 10.18926/AMO/31591 |
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FullText URL | fulltext.pdf |
Author | Ohnoshi, Taisuke| Hiraki, Shunkichi| Fujii, Masafumi| Ueoka, Hiroshi| Yonei, Toshiro| Tamura, Makoto| Moritaka, Tomonori| Mima, Yuchi| Horiguchi, Takashi| Kiura, Katsuyuki| Kamei, Haruhito| Kodani, Tsuyoshi| Hiraki, Yoshio| Kimura, Ikuro| |
Abstract | We evaluated the long-term outcome of 148 patients with small cell lung cancer (SCLC) who had been entered into clinical trials of chemotherapy with or without thoracic and prophylactic cranial irradiation (PCI) between 1981 and 1987. Eighteen patients (12%) survived for 2 or more years. With a minimum follow-up of 4.5 years, 10 of the 18 patients who remained disease-free at 2 years are currently alive and free of SCLC. Seven of these 10 patients currently function as they did before diagnosis. However, three suffer from central nervous system changes of varying degrees in severity which appeared 2-3 years after PCI. Eight of the 18 patients who were disease-free at 2 years have died. Two died of isolated relapse in the brain at 3.6 and 4.2 years after initiation of chemotherapy. Five died of other malignancies while continuing their complete response to SCLC; two of non-small cell lung cancer, two of acute myelogenous leukemia, and one of hepatocellular carcinoma. Another patient died of an unrelated disease without any evidence of SCLC. A small but substantial proportion of patients who underwent intensive treatment will achieve long-term survival; however, these patients remain at higher risk for second cancers and late toxicities. Therefore, attention must be directed to defining the safest way to employ such treatment in the management of SCLC. |
Keywords | small cell lung cancer long-term survivors late relapse toxicities complications |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1993-06 |
Volume | volume47 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 209 |
End Page | 214 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 8397470 |
Web of Science KeyUT | A1993LL12400010 |
FullText URL | fulltext.pdf |
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Author | Morinaga, Takao| Inozume, Takashi| Kawazu, Masahito| Ueda, Youki| Sax, Nicolas| Yamashita, Kazuo| Kawashima, Shusuke| Nagasaki, Joji| Ueno, Toshihide| Lin, Jason| Ohara, Yuuki| Kuwata, Takeshi| Yukami, Hiroki| Kawazoe, Akihito| Shitara, Kohei| Honobe-Tabuchi, Akiko| Ohnuma, Takehiro| Kawamura, Tatsuyoshi| Umeda, Yoshiyasu| Kawahara, Yu| Nakamura, Yasuhiro| Kiniwa, Yukiko| Morita, Ayako| Ichihara, Eiki| Kiura, Katsuyuki| Enokida, Tomohiro| Tahara, Makoto| Hasegawa, Yoshinori| Mano, Hiroyuki| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Togashi, Yosuke| |
Published Date | 2022-07-28 |
Publication Title | Cancer Research Communications |
Volume | volume2 |
Issue | issue7 |
Publisher | American Association for Cancer Research |
Start Page | 739 |
End Page | 753 |
ISSN | 2767-9764 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors |
File Version | publisher |
PubMed ID | 36923281 |
DOI | 10.1158/2767-9764.CRC-22-0050 |
Web of Science KeyUT | 001048412300001 |
Related Url | isVersionOf https://doi.org/10.1158/2767-9764.CRC-22-0050 |
FullText URL | fulltext.pdf |
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Author | Taoka, Masataka| Makimoto, Go| Umakoshi, Noriyuki| Ninomiya, Kiichiro| Higo, Hisao| Kato, Yuka| Fujii, Masanori| Kubo, Toshio| Ichihara, Eiki| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | Hemoptysis Bronchial artery embolization Endoscopic bronchial occlusion Endobronchial Watanabe Spigot |
Published Date | 2022 |
Publication Title | Respiratory Medicine Case Reports |
Volume | volume38 |
Publisher | Elsevier |
Start Page | 101669 |
ISSN | 2213-0071 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors. |
File Version | publisher |
PubMed ID | 35646587 |
DOI | 10.1016/j.rmcr.2022.101669 |
Web of Science KeyUT | 001089212200003 |
Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2022.101669 |
FullText URL | fulltext.pdf |
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Author | Okawa, Sachi| Rai, Kammei| Fujii, Nobuharu| Gion, Yuka| Ninomiya, Kiichiro| Kato, Yuka| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Ohashi, Kadoaki| Miyahara, Nobuaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | EGFR IgG4-related disease marginal zone lymphoma osimertinib |
Published Date | 2021-09-01 |
Publication Title | Internal Medicine |
Volume | volume60 |
Issue | issue17 |
Publisher | The Japanese Society of Internal Medicine |
Start Page | 2831 |
End Page | 2837 |
ISSN | 0918-2918 |
NCID | AA10827774 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 The Japanese Society of Internal Medicine |
File Version | publisher |
PubMed ID | 33775999 |
DOI | 10.2169/internalmedicine.6470-20 |
Web of Science KeyUT | 000695856000020 |
Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.6470-20 |
FullText URL | fulltext.pdf |
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Author | Ichihara, Eiki| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | lung cancer interstitial pneumonia |
Published Date | 2020-01-15 |
Publication Title | Internal Medicine |
Volume | volume59 |
Issue | issue2 |
Publisher | 日本内科学会 |
Start Page | 163 |
End Page | 167 |
ISSN | 0918-2918 |
NCID | AA10827774 |
Content Type | Journal Article |
language | English |
Copyright Holders | © 2020 by The Japanese Society of Internal Medicine |
File Version | publisher |
PubMed ID | 31534086 |
DOI | 10.2169/internalmedicine.3481-19 |
NAID | 130007785095 |
Web of Science KeyUT | 000507577600002 |
Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.3481-19 |
JaLCDOI | 10.18926/AMO/31553 |
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FullText URL | fulltext.pdf |
Author | Tabata, Masahiro| Ohnoshi, Taisuke| Ueoka, Hiroshi| Kiura, Katsuyuki| Kimura, Ikuro| |
Abstract | We report a preliminary study to determine whether MDR1 gene expression level in small cell lung cancer (SCLC) tumors is a useful predictor of tumor response to chemotherapy and patient survival in association with myc amplification in the tumor. We analyzed 18 patients with SCLC receiving adriamycin and etoposide combination chemotherapy between August 1989 and November 1991; 16 males and 2 females, median age of 68 years, and 7 with limited disease and 11 with extensive disease. MDR1 mRNA expression level and myc family gene amplification were simultaneously determined by polymerase chain reaction using transbronchial biopsy specimens which were obtained at diagnosis. Patients with tumors expressing low MDR1 mRNA responded more favorably to chemotherapy than those with tumors expressing high MDRI mRNA, however, the difference in tumor response was statistically not significant (84.6% versus 40%). The overall survival was significantly shorter in the latter than in the former (7.2 months versus 11.7 months; p = 0.023). The survival of the 4 patients with tumor showing myc family gene amplification was almost identical to that of patients with tumors showing no amplification of the gene (8.2 months versus 8.8 months; p = 0.73). Multivariate Cox's regression analysis supports the notion that MDR1 may be a useful independent prognostic factor. |
Keywords | small cell lung cancer MDR1 mRNA expression myc gene amplification prognostic factor |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1993-08 |
Volume | volume47 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 243 |
End Page | 248 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 8213218 |
Web of Science KeyUT | A1993LV73800004 |
FullText URL | fulltext.pdf |
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Author | Watanabe, Kenta| Katsui, Kuniaki| Sugiyama, Soichiro| Yoshio, Kotaro| Kuroda, Masahiro| Hiraki, Takao| Kiura, Katsuyuki| Maeda, Yoshinobu| Toyooka, Shinichi| Kanazawa, Susumu| |
Keywords | Clinical pathology Elderly Non-small cell lung carcinoma Radiosurgery Stereotactic body radiation therapy |
Published Date | 2021-02-23 |
Publication Title | Radiation Oncology |
Volume | volume16 |
Issue | issue1 |
Publisher | BMC |
Start Page | 39 |
ISSN | 1748-717X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2021. |
File Version | publisher |
PubMed ID | 33622369 |
DOI | 10.1186/s13014-021-01769-7 |
Web of Science KeyUT | 000623175000001 |
Related Url | isVersionOf https://doi.org/10.1186/s13014-021-01769-7 |
Author | Hayakawa, Hiromi| Ichihara, Eiki| Ohashi, Kadoaki| Ninomiya, Takashi| Yasugi, Masayuki| Takata, Saburo| Sakai, Katsuya| Matsumoto, Kunio| Takigawa, Nagio| Tanimoto, Mitsune| Kiura, Katsuyuki| |
---|---|
Published Date | 2013-11 |
Publication Title | Cancer Science |
Volume | volume104 |
Issue | issue11 |
Content Type | Journal Article |
FullText URL | fulltext20231004-03.pdf fig1_20231004-03.pdf fig2_20231004-03.pdf fig3_20231004-03.pdf fig4_20231004-03.pdf fig5_20231004-03.pdf Suppl20231004-03.pdf |
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Author | Kemmotsu, Naoya| Ninomiya, Kiichiro| Kunimasa, Kei| Ishino, Takamasa| Nagasaki, Joji| Otani, Yoshihiro| Michiue, Hiroyuki| Ichihara, Eiki| Ohashi, Kadoaki| Inoue, Takako| Tamiya, Motohiro| Sakai, Kazuko| Ueda, Youki| Dansako, Hiromichi| Nishio, Kazuto| Kiura, Katsuyuki| Date, Isao| Togashi, Yosuke| |
Keywords | cancer immunotherapy intracranial metastasis intracranial progression memory precursor effector T cell nonsmall-cell lung cancer |
Note | This is the peer reviewed version of the following article: [Kemmotsu N, Ninomiya K, Kunimasa K, et al. Low frequency of intracranial progression in advanced NSCLC patients treated with cancer immunotherapies. Int J Cancer. 2024; 154(1): 169-179. doi:10.1002/ijc.34700], which has been published in final form at [https://doi.org/10.1002/ijc.34700]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Aug. 2024.| |
Published Date | 2023-08-23 |
Publication Title | International Journal of Cancer |
Volume | volume154 |
Issue | issue1 |
Publisher | Wiley |
Start Page | 169 |
End Page | 179 |
ISSN | 0020-7136 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 UICC. |
File Version | author |
PubMed ID | 37611176 |
DOI | 10.1002/ijc.34700 |
Web of Science KeyUT | 001069876600001 |
Related Url | isVersionOf https://doi.org/10.1002/ijc.34700 |
FullText URL | fulltext.pdf |
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Author | Makimoto, Go| Ohashi, Kadoaki| Taniguchi, Kohei| Soh, Junichi| Taniguchi, Akihiko| Miyahara, Nobuaki| Toyooka, Shinichi| Yoshino, Tadashi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | IgG4-related disease Pleural effusion Adenosine deaminase Pleural biopsy Spontaneous remission |
Published Date | 2019 |
Publication Title | Respiratory Medicine Case Reports |
Volume | volume28 |
Publisher | Elsevier |
Start Page | 100938 |
ISSN | 2213-0071 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. |
File Version | publisher |
PubMed ID | 31667074 |
DOI | 10.1016/j.rmcr.2019.100938 |
Web of Science KeyUT | 000511444900052 |
Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2019.100938 |
Author | Rai, Kammei| Takigawa, Nagio| Ito, Sachio| Kashihara, Hiromi| Ichihara, Eiki| Yasuda, Tatsuji| Shimizu, Kenji| Tanimoto, Mitsune| Kiura, Katsuyuki| |
---|---|
Published Date | 2011-09 |
Publication Title | Molecular Cancer Therapeutics |
Volume | volume10 |
Issue | issue9 |
Content Type | Journal Article |
Author | Harada, Daijiro| Takigawa, Nagio| Ochi, Nobuaki| Ninomiya, Takashi| Yasugi, Masayuki| Kubo, Toshio| Takeda, Hiromasa| Ichihara, Eiki| Ohashi, Kadoaki| Takata, Saburo| Tanimoto, Mitsune| Kiura, Katsuyuki| |
---|---|
Published Date | 2012-10 |
Publication Title | Cancer Science |
Volume | volume103 |
Issue | issue10 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/46851 |
---|---|
FullText URL | 65_4_259.pdf |
Author | Ogata, Yoshiko| Aoe, Keisuke| Hiraki, Akio| Murakami, Kazuo| Kishino, Daizo| Chikamori, Kenichi| Maeda, Tadashi| Ueoka, Hiroshi| Kiura, Katsuyuki| Tanimoto, Mitsune| |
Abstract | The objective of this study was to evaluate the utility of the determination of adenosine deaminase (ADA) level in pleural fluid for the differential diagnosis between tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) in Japan, a country with intermediate incidence of tuberculosis (TB). We retrospectively reviewed the clinical records of 435 patients with pleural effusion and investigated their pleural ADA levels as determined by an auto analyzer. ROC analysis was also performed. The study included patients with MPE (n=188), TPE (n=124), benign nontuberculous pleural effusion (n=94), and pleural effusion of unknown etiology (n=29). The median ADA level in the TPE group was 70.8U/L, which was significantly higher than that in any other groups (p<0.05). The area under the curve (AUC) in ROC analysis was 0.895. With a cut-off level for ADA of 36U/L, the sensitivity, specificity, positive predictive value, and negative predictive value were 85.5%, 86.5%, 69.7%, and 93.6%, respectively. As many as 9% of patients with lung cancer and 15% of those with mesothelioma were false-positive with this ADA cutoff setting. Although the ADA activity in pleural fluid can help in the diagnosis of TPE, it should be noted that some cases of lung cancer or mesothelioma show high ADA activity in geographical regions with intermediate incidence of TB, in contrast to high prevalence areas. |
Keywords | pleural effusion adenosine deaminase tuberculosis lung cancer mesothelioma |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2011-08 |
Volume | volume65 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 259 |
End Page | 263 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 21860532 |
Web of Science KeyUT | 000294236700006 |
JaLCDOI | 10.18926/AMO/31590 |
---|---|
FullText URL | fulltext.pdf |
Author | Segawa, Yoshihiko| Ohnoshi, Taisuke| Hiraki, Shunkichi| Ueoka, Hiroshi| Kiura, Katsuyuki| Kamei, Haruhito| Tabata, Masahiro| Shibayama, Takuo| Miyatake, Kazuyo| Genda, ken-ichi| Matsumura, Tadashi| Kimura, Ikuro| |
Abstract | In an attempt to elucidate the tumor properties relating to responsiveness to chemotherapy, we examined immunohistochemically the expression of P-glycoprotein (P-gp) and carcinoembryonic antigen (CEA) in small cell lung cancer (SCLC) tumors. Tumor specimens from 33 patients were obtained at the time of diagnosis and relapse. Four patients expressed P-gp in their initial tumors, and 7 others did in recurrent tumors. The overall response rate to chemotherapy of the initial tumors was 75% for P-gp-positive initial tumors and 86% for P-gp-negative tumors, whereas the disease-free and overall survival times were significantly shorter in the former than the latter. Three patients showed CEA in their initial tumors, and 5 others did in recurrent tumors. The patients with CEA-positive initial tumors tended to relapse earlier than those with CEA-negative tumors. In addition, recurrent tumors expressing CEA were resistant to salvage chemotherapy. A clear correlation between CEA expression by tumors and the CEA level in the serum was observed at diagnosis as well as at relapse. These findings indicate that P-gp and/or CEA expression by a tumor and elevated CEA level in the serum may predict refractoriness of the tumor to chemotherapy. |
Keywords | small cell lung cancer immunohistochemistry drug resistance P-glycoprotein carcinoembryonic antigen |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1993-06 |
Volume | volume47 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 181 |
End Page | 189 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 8104371 |
Web of Science KeyUT | A1993LL12400007 |