| Author | Hayakawa, Hiromi| Ichihara, Eiki| Ohashi, Kadoaki| Ninomiya, Takashi| Yasugi, Masayuki| Takata, Saburo| Sakai, Katsuya| Matsumoto, Kunio| Takigawa, Nagio| Tanimoto, Mitsune| Kiura, Katsuyuki| |
|---|---|
| Published Date | 2013-11 |
| Publication Title | Cancer Science |
| Volume | volume104 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Murakami, Toshi| Takigawa, Nagio| Ninomiya, Takashi| Ochi, Nobuaki| Yasugi, Masaaki| Honda, Yoshihiro| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Tanimoto, Mitsune| Kiura, Katsuyuki| |
|---|---|
| Published Date | 2014-01 |
| Publication Title | Lung Cancer |
| Volume | volume83 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Ochi, Nobuaki| Takigawa, Nagio| Harada, Daijiro| Yasugi, Masayuki| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Tanimoto, Mitsune| Kiura, Katsuyuki| |
|---|---|
| Published Date | 2014-03-10 |
| Publication Title | Experimental Cell Research |
| Volume | volume322 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yasugi, Masayuki| Takigawa, Nagio| Ochi, Nobuaki| Ohashi, Kadoaki| Harada, Daijiro| Ninomiya, Takashi| Murakami, Toshi| Honda, Yoshihiro| Ichihara, Eiki| Tanimoto, Mitsune| Kiura, Katsuyuki| |
|---|---|
| Published Date | 2014-08-15 |
| Publication Title | Experimental Cell Research |
| Volume | volume326 |
| Issue | issue2 |
| Content Type | Journal Article |
| Title Alternative | A prospective cohort study to define the clinical and pathological features of lung cancers harboring HER2 gene aberrations (the HER2-CS Study) and a phase II study of trastuzumab emtansine (recombinant) in patients with HER2-positive non-small cell lung cancer who recurred, progressed after standard chemotherapy, or were primarily refractory to standard chemotherapy |
|---|---|
| FullText URL | 127_127.pdf |
| Author | Kiura, Katsuyuki| Hotta, Katsuyuki| Sato, Akiko| Ohashi, Kadoaki| Ninomiya, Takashi| Minnami, Daisuke| Tabata, Masahiro| Kubo, Toshio| Kato, Yuka| Hirata, Taizo| |
| Keywords | 臨床研究中核病院 国立研究開発法人日本医療研究開発機構 文部科学省橋渡し研究加速ネットワークプログラム HER2-CS study trastuzumab emtansine |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-08-03 |
| Volume | volume127 |
| Issue | issue2 |
| Start Page | 127 |
| End Page | 132 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.127.127 |
| language | 日本語 |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.127 |
| NAID | 130005096256 |
| JaLCDOI | 10.18926/AMO/53671 |
|---|---|
| FullText URL | 69_5_261.pdf |
| Author | Nojima, Daisuke| Fujimoto, Nobukazu| Kato, Katsuya| Fuchimoto, Yasuko| Kiura, Katsuyuki| Kishimoto, Takumi| Tanimoto, Mitsune| |
| Abstract | We investigated the clinical features of asbestos-induced diffuse pleural thickening (DPT) with severe respiratory compromise. We conducted a retrospective study of consecutive subjects with asbestos-induced DPT. Medical data such as initial symptoms, radiological findings, respiratory function test results, and clinical course were collected and analyzed. There were 24 patients between 2003 and 2012. All were men, and the median age at the development of DPT was 74 years. The top occupational category associated with asbestos exposure was dockyard workers. The median duration of asbestos exposure was 35.0 years, and the median latency from first exposure to the onset of DPT was 49.0 years. There were no significant differences in respiratory function test results between the higher and lower Brinkman index groups or between unilateral and bilateral DPT. Thirteen patients had a history of benign asbestos pleural effusion (BAPE), and the median duration from pleural fluid accumulation to DPT with severe respiratory compromise was 28.4 months. DPT with severe respiratory compromise can develop after a long latency following occupational asbestos exposure and a history of BAPE. |
| Keywords | asbestos pleural thickening MRC dyspnea scale respiratory function test costophrenic angle |
| Amo Type | Original Article |
| Published Date | 2015-10 |
| Publication Title | Acta Medica Okayama |
| Volume | volume69 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 261 |
| End Page | 266 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26490022 |
| Web of Science KeyUT | 000365519600001 |
| JaLCDOI | 10.18926/AMO/54499 |
|---|---|
| FullText URL | 70_4_243.pdf |
| Author | Osawa, Masahiro| Ohashi, Kadoaki| Kubo, Toshio| Ichihara, Eiki| Takata, Saburo| Takigawa, Nagio| Takata , Minoru| Tanimoto, Mitsune| Kiura, Katsuyuki| |
| Abstract | Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p＜0.01); resistance to vandetanib occurred at 20 weeks of age and the animals died from their lung tumors at about 28 weeks of age. These data suggest that vandetanib could suppress the progression of tumors harboring an activating EGFR mutation. |
| Keywords | vandetanib VEGFR EGFR nonsmall cell lung cancer transgenic mouse |
| Amo Type | Original Article |
| Published Date | 2016-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549668 |
| Web of Science KeyUT | 000384748600003 |
| JaLCDOI | 10.18926/AMO/54503 |
|---|---|
| FullText URL | 70_4_273.pdf |
| Author | Makimoto, Go| Miyahara, Nobuaki| Yoshikawa, Mao| Taniguchi, Akihiko| Kanehiro, Arihiko| Tanimoto, Mitsune| Kiura, Katsuyuki| |
| Abstract | Heerfordtʼs syndrome is a rare manifestation of sarcoidosis and is defined as a combination of facial palsy, parotid swelling, and uveitis, associated with a low-grade fever. We report a case of Heerfordtʼs syndrome presenting with a high fever and increased serum tumor necrosis factor alpha (TNF-α) levels. The patient had facial palsy, parotid swelling, uveitis, and swelling of the right supraclavicular and hilar lymph nodes. Corticosteroid therapy was initiated, and her symptoms soon resolved completely, in tandem with a decrease in TNF-α serum levels. |
| Keywords | Heerfordtʼs syndrome sarcoidosis TNF-α |
| Amo Type | Case Report |
| Published Date | 2016-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 273 |
| End Page | 277 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549672 |
| Web of Science KeyUT | 000384748600007 |
| JaLCDOI | 10.18926/AMO/54514 |
|---|---|
| FullText URL | 70_4_327.pdf |
| Author | Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi| |
| Abstract | A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines. |
| Keywords | metformin CD8＋ T cells cancer immunology |
| Amo Type | Clinical Study Protocols |
| Published Date | 2016-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 327 |
| End Page | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549683 |
| Web of Science KeyUT | 000384748600018 |
| JaLCDOI | 10.18926/AMO/55446 |
|---|---|
| FullText URL | 71_5_453.pdf |
| Author | Taniguchi, Akihiko| Miyahara, Nobuaki| Oda, Naohiro| Morichika, Daisuke| Ichihara, Eiki| Oze, Isao| Tanimoto, Yasushi| Ichikawa, Hirohisa| Fujii, Utako| Tanimoto, Mitsune| Kanehiro, Arihiko| Kiura, Katsuyuki| |
| Abstract | Although recent retrospective studies suggested that the use of β-blockers appears to help improve the mortality rate and decrease the rate of exacerbation in chronic obstructive pulmonary disease (COPD) patients with heart failure, the effects of β-blockers on COPD patients without heart failure have not been established. Based on previous reports, we have launched a multicenter, prospective, single-arm phase II study to evaluate the preventive effect of the cardioselective β-blocker bisoprolol in COPD exacerbation, in Japanese individuals with moderate-to-severe COPD who do not have heart failure but do have hypertension requiring the use of medication. The primary endpoint is the rate of mild-to-severe COPD exacerbation. The results of this study will clarify whether bisoprolol can prevent exacerbation in COPD patients without heart failure. |
| Keywords | chronic obstructive pulmonary disease β-blocker bisoprolol exacerbation heart failure |
| Amo Type | Clinical Study Protocol |
| Published Date | 2017-10 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 453 |
| End Page | 457 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29042706 |
| FullText URL | J_Thorac_Oncol_201907017.pdf |
|---|---|
| Author | Makimoto, Go| Ohashi, Kadoaki| Tomida, Shuta| Nishii, Kazuya| Matsubara, Takehiro| Kayatani, Hiroe| Higo, Hisao| Ninomiya, Kiichiro| Sato, Akiko| Watanabe, Hiromi| Kano, Hirohisa| Ninomiya, Takashi| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Takata, Minoru| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | ALK G1202R Alectinib Amphiregulin MET NSCLC |
| Published Date | 2019-07-30 |
| Publication Title | Journal of Thoracic Oncology |
| Volume | volume14 |
| Issue | issue11 |
| Publisher | Elsevier |
| Start Page | 2009 |
| End Page | 2018 |
| ISSN | 15560864 |
| NCID | AA12058455 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. |
| File Version | author |
| PubMed ID | 31374369 |
| DOI | 10.1016/j.jtho.2019.07.017 |
| Web of Science KeyUT | 000492678300025 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jtho.2019.07.017 |
| FullText URL | BMCC19_1_1144.pdf |
|---|---|
| Author | Katsui, Kuniaki| Ogata, Takeshi| Watanabe, Kenta| Katayama, Norihisa| Soh, Junichi| Kuroda, Masahiro| Kiura, Katsuyuki| Maeda, Yoshinobu| Toyooka, Shinichi| Kanazawa, Susumu| |
| Keywords | Induction chemoradiotherapy Lower lobe Mean lung dose Non-small cell lung cancer Radiation pneumonitis |
| Published Date | 2019-11 |
| Publication Title | BMC Cancer |
| Volume | volume19 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 1144 |
| ISSN | 1471-2407 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2019 |
| File Version | publisher |
| PubMed ID | 31771538 |
| DOI | 10.1186/s12885-019-6359-9 |
| Web of Science KeyUT | 000499423900004 |
| Related Url | isVersionOf https://doi.org/10.1186/s12885-019-6359-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Itano, Junko| Ohashi, Kadoaki| Senoo, Satoru| Oda, Naohiro| Nishii, Kazuya| Taniguchi, Akihiko| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | Axillary lymphadenitis Mycobacterium avium complex infection Mycobacterium intracellulare |
| Published Date | 2019 |
| Publication Title | Respiratory Medicine Case Reports |
| Volume | volume28 |
| Publisher | Elsevier |
| Start Page | 100947 |
| ISSN | 2213-0071 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 31681532 |
| DOI | 10.1016/j.rmcr.2019.100947 |
| Web of Science KeyUT | 000511444900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2019.100947 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Makimoto, Go| Ohashi, Kadoaki| Taniguchi, Kohei| Soh, Junichi| Taniguchi, Akihiko| Miyahara, Nobuaki| Toyooka, Shinichi| Yoshino, Tadashi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | IgG4-related disease Pleural effusion Adenosine deaminase Pleural biopsy Spontaneous remission |
| Published Date | 2019 |
| Publication Title | Respiratory Medicine Case Reports |
| Volume | volume28 |
| Publisher | Elsevier |
| Start Page | 100938 |
| ISSN | 2213-0071 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 31667074 |
| DOI | 10.1016/j.rmcr.2019.100938 |
| Web of Science KeyUT | 000511444900052 |
| Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2019.100938 |
| FullText URL | fulltext.pdf figs.pdf tables.pdf |
|---|---|
| Author | Itano, Junko| Higo, Hisao| Ohashi, Kadoaki| Makimoto, Go| Nishii, Kazuya| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | osimertinib drug-induced ILD reversed halo sign organizing pneumonia pattern re-administration |
| Published Date | 2020-03-15 |
| Publication Title | Internal Medicine |
| Volume | volume59 |
| Issue | issue6 |
| Publisher | The Japanese Society of Internal Medicine |
| Start Page | 823 |
| End Page | 828 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by The Japanese Society of Internal Medicine |
| File Version | author |
| PubMed ID | 31787696 |
| DOI | 10.2169/internalmedicine.3689-19 |
| Web of Science KeyUT | 000521137500011 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.3689-19 |
| FullText URL | fulltext.pdf figure.pptx |
|---|---|
| Author | Higo, Hisao| Miyahara, Nobuaki| Taniguchi, Akihiko| Senoo, Satoru| Itano, Junko| Watanabe, Hiromi| Oda, Naohiro| Kayatani, Hiroe| Ichikawa, Hirohisa| Shibayama, Takuo| Kajimoto, Kazuhiro| Tanimoto, Yasushi| Kanehiro, Arihiko| Maeda, Yoshinobu| Kiura, Katsuyuki| OKAYAMA respiratory disease study group (ORDSG)| |
| Keywords | Idiopathic pulmonary fibrosis High-resolution computed tomography Pirfenidone Forced vital capacity |
| Note | This fulltext is available in Feb. 2021.| |
| Published Date | 2020-02-23 |
| Publication Title | Respiratory Investigation |
| Volume | volume58 |
| Issue | issue3 |
| Publisher | Elsevier |
| Start Page | 185 |
| End Page | 189 |
| ISSN | 22125345 |
| NCID | AA12579673 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | author |
| PubMed ID | 32102769 |
| DOI | 10.1016/j.resinv.2019.12.007 |
| Web of Science KeyUT | 000531841500009 |
| Related Url | isVersionOf https://doi.org/10.1016/j.resinv.2019.12.007 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katsui, Kuniaki| Ogata, Takeshi| Watanabe, Kenta| Katayama, Norihisa| Kuroda, Masahiro| Kiura, Katsuyuki| Hiraki, Takao| Maeda, Yoshinobu| Toyooka, Shinichi| Kanazawa, Susumu| |
| Keywords | cisplatin docetaxel dose-volume histogram non-small cell lung cancer PACIFIC trial radiation pneumonitis |
| Published Date | 2020-05-04 |
| Publication Title | Cancer Medicine |
| Publisher | Wiley |
| ISSN | 2045-7634 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32364685 |
| DOI | 10.1002/cam4.3093 |
| Web of Science KeyUT | 000530411600001 |
| Related Url | isVersionOf https://doi.org/10.1002/cam4.3093 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sugimoto, Seiichiro| Soh, Junichi| Suzawa, Ken| Miyoshi, Kentaroh| Otani, Shinji| Yamamoto, Hiromasa| Okazaki, Mikio| Yamane, Masaomi| Oto, Takahiro| Kanazawa, Susumu| Kiura, Katsuyuki| Toyooka, Shinichi| |
| Keywords | Lung cancer Aspergillosis Surgery Radiation Chemotherapy |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-020-01960-5.| |
| Published Date | 2020-01-21 |
| Publication Title | Surgery Today |
| Volume | volume50 |
| Issue | issue8 |
| Publisher | Springer |
| Start Page | 863 |
| End Page | 871 |
| ISSN | 0941-1291 |
| NCID | AA10824685 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31965262 |
| DOI | 10.1007/s00595-020-01960-5 |
| Web of Science KeyUT | 000550244700010 |
| Related Url | isVersionOf https://doi.org/10.1007/s00595-020-01960-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kano, Hirohisa| Ichihara, Eiki| Harada, Daijiro| Inoue, Koji| Kayatani, Hiroe| Hosokawa, Shinobu| Kishino, Daizo| Watanabe, Kazuhiko| Ochi, Nobuaki| Oda, Naohiro| Hara, Naofumi| Ninomiya, Kiichiro| Hotta, Katsuyuki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | immune checkpoint inhibitor non-small cell-lung cancer PD-L1 pembrolizumab poor performance status |
| Published Date | 2020-07-29 |
| Publication Title | Cancer Science |
| Volume | volume111 |
| Issue | issue10 |
| Publisher | Wiley |
| Start Page | 3739 |
| End Page | 3746 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32726470 |
| DOI | 10.1111/cas.14590 |
| Web of Science KeyUT | 000562490200001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.14590 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Senoo, Satoru| Miyahara, Nobuaki| Taniguchi, Akihiko| Oda, Naohiro| Itano, Junko| Higo, Hisao| Hara, Naofumi| Watanabe, Hiromi| Kano, Hirohisa| Suwaki, Toshimitsu| Fuchimoto, Yasuko| Kajimoto, Kazuhiro| Ichikawa, Hirohisa| Kudo, Kenichiro| Shibayama, Takuo| Tanimoto, Yasushi| Kuyama, Shoichi| Kanehiro, Arihiko| Maeda, Yoshinobu| Kiura, Katsuyuki| Okayama Respiratory Disease Study Group (ORDSG)| |
| Published Date | 2020-08-27 |
| Publication Title | PLoS ONE |
| Volume | volume15 |
| Issue | issue8 |
| Publisher | Public Library of Science |
| Start Page | e0236935 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Senoo et al. |
| File Version | publisher |
| PubMed ID | 32853277 |
| DOI | 10.1371/journal.pone.0236935 |
| Web of Science KeyUT | 000566948800009 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0236935 |
