| JaLCDOI | 10.18926/AMO/30974 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Ikuma, Hisanori| Abe, Nobuhiro| Uchida, Youichiro| Furumatsu, Takayuki| Fujiwara, Kazuo| Nishida, Keiichiro| Ozaki, Toshifumi| |
| 抄録 | <p>Instability of the knee after the medial collateral ligament (MCL) injury is usually assessed with the manual valgus stress test, even though, in recent years, it has become possible to apply magnetic resonance imaging (MRI) to the assessment of the damage of the ligament. The valgus instability of 24 patients (12 isolated injuries and 12 multiple ligament injuries) who suffered MCL injury between 1993 and 1998 was evaluated with the Hughston and Eilers classification, which involves radiographic assessment under manual valgus stress to the injured knees. We developed a novel system for classifying the degree of injury to the MCL by calculating the percentage of injured area based on MRI and investigated the relationship between this novel MRI classification and the magnitude of valgus instability by the Hughston and Eilers classification. There was a significant correlation between the 2 classifications (p=0.0006). On the other hand, the results using other MRI based classification systems, such as the Mink and Deutsch classificaiton and the Petermann classification, were not correlated with the findings by the Hughston and Eilers classification in these cases (p0.05). Since MRI is capable of assessing the injured ligament in clinical practice, this novel classification system would be useful for evaluating the stability of the knee and choosing an appropriate treatment following MCL injury.</p> |
| キーワード | medial collateral ligament magnetic resonance imaging knee instability novel method |
| Amo Type | Original Article |
| 発行日 | 2008-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 62巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 185 |
| 終了ページ | 191 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 18596835 |
| Web of Science KeyUT | 000257130300006 |
| JaLCDOI | 10.18926/AMO/58274 |
|---|---|
| フルテキストURL | 74_2_151.pdf |
| 著者 | Yamamoto, Norio| Dan’ura, Tomoyuki| Noda, Tomoyuki| Ozaki, Toshifumi| |
| 抄録 | This is the second report of an atypical peri-implant femoral fracture occurring at the distal screw after intramedullary nail fixation of a pertrochanteric fracture. A 94-year-old Japanese female with a 5-year history of alendronate intake presented with prodromal pain in her right thigh after intramedullary nail fixation. Plain radiographs showed an incomplete noncomminuted transverse fracture at the distal screw, suggesting an atypical peri-implant femoral fracture. The pathogenesis of an atypical peri-implant femoral fracture could be a combined systemic bone metabolism disorder and repetitive overloading at the screw, similar to the pathogenesis of an atypical periprosthetic femoral fracture around stem implantation. |
| キーワード | atypical femoral fracture insufficiency fracture bisphosphonate atypical peri-implant femoral fracture, atypical periprosthetic femoral fracture |
| Amo Type | Case Report |
| 発行日 | 2020-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 74巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 151 |
| 終了ページ | 157 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32341590 |
| Web of Science KeyUT | 000528278500009 |
| NAID | 120006839453 |
| JaLCDOI | 10.18926/AMO/54807 |
|---|---|
| フルテキストURL | 70_6_449.pdf |
| 著者 | Watanabe, Noriyuki| Sugimoto, Yoshihisa| Tanaka, Masato| Mazaki, Tetsuro| Arataki, Shinya| Takigawa, Tomoyuki| Kataoka, Masaki| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| 抄録 | Metastatic epidural spinal cord compression (MESCC) is a common complication in patients with a malignant tumor, but it is difficult to decide the proper time to perform the necessary surgery. Here we analyzed the prognostic factors for postoperative walking ability. We retrospectively reviewed the cases of 112 MESCC patients treated surgically at our institute and divided them into ambulatory (n＝ 88) and non-ambulatory (n＝24) groups based on their American Spinal Injury Association (ASIA) Impairment Scale grades at the final follow-up. We also classified the patients preoperatively using the revised Tokuhashi score. We assessed the correlation between preoperative or intraoperative factors and postoperative walking ability in both groups. Of the 10 patients classified preoperatively as grade A or B, 2 (20 ) were ambulatory at the final follow-up. Of the 102 patients classified preoperatively as grade C, D or E, 86 (84 ) were ambulatory at the final follow-up (p＜0.001). There were no significant differences between the groups in the average total Tokuhashi score. Our analysis revealed that the severity of paralysis significantly affects neurological recovery in patients with MESCC. Patients with MESCC should receive surgery before the preoperative ASIA Impairment Scale grade falls below grade C. |
| キーワード | metastatic epidural spinal cord compression American Spinal Injury Association Impairment Scale Tokuhashi score walking ability prognostic factor |
| Amo Type | Original Article |
| 発行日 | 2016-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 70巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 449 |
| 終了ページ | 453 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28003669 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamane, Kentaro| Misawa, Haruo| Takigawa, Tomoyuki| Ito, Yoshihiro| Ozaki, Toshifumi| Matsukawa, Akihiro| |
| キーワード | hepatocyte growth factor spinal cord injury neural regeneration |
| 発行日 | 2019-12-02 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 20巻 |
| 号 | 23号 |
| 出版者 | MDPI |
| 開始ページ | 6078 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2019 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 31810304 |
| DOI | 10.3390/ijms20236078 |
| Web of Science KeyUT | 000504428300260 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms20236078 |
| JaLCDOI | 10.18926/AMO/49255 |
|---|---|
| フルテキストURL | 67_1_35.pdf |
| 著者 | Watanabe, Masutaka| Arita, Seizaburo| Hashizume, Hiroyuki| Honda, Mitsugi| Nishida, Keiichiro| Ozaki, Toshifumi| |
| 抄録 | The purpose of this study was to quantitatively evaluate Akahori's preoperative classification of cubital tunnel syndrome. We analyzed the results for 57 elbows that were treated by a simple decompression procedure from 1997 to 2004. The relationship between each item of Akahori's preoperative classification and clinical stage was investigated based on the parameter distribution. We evaluated Akahori's classification system using multiple regression analysis, and investigated the association between the stage and treatment results. The usefulness of the regression equation was evaluated by analysis of variance of the expected and observed scores. In the parameter distribution, each item of Akahori's classification was mostly associated with the stage, but it was difficult to judge the severity of palsy. In the mathematical evaluation, the most effective item in determining the stage was sensory conduction velocity. It was demonstrated that the established regression equation was highly reliable (R＝0.922). Akahori's preoperative classification can also be used in postoperative classification, and this classification was correlated with postoperative prognosis. Our results indicate that Akahori's preoperative classification is a suitable system. It is reliable, reproducible and well-correlated with the postoperative prognosis. In addition, the established prediction formula is useful to reduce the diagnostic complexity of Akahori's classification. |
| キーワード | cubital tunnel syndrome ulnar nerve Akahoriʼs classification multiple regression analysis |
| Amo Type | Original Article |
| 発行日 | 2013-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 35 |
| 終了ページ | 44 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439507 |
| Web of Science KeyUT | 000316829900005 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50647 |
| フルテキストURL | KSSTA27_2_361.pdf Figs.pdf Table.pdf |
|---|---|
| 著者 | Okazaki, Yoshiki| Furumatsu, Takayuki| Miyazawa, Shinichi| Kodama, Yuya| Kamatsuki, Yusuke| Hino, Tomohito| Masuda, Shin| Ozaki, Toshifumi| |
| キーワード | Anterior cruciate ligament reconstruction Flexed-knee position Medial meniscus Meniscal repair Open magnetic resonance imaging Posterior shift |
| 発行日 | 2018-09-24 |
| 出版物タイトル | Knee Surgery, Sports Traumatology, Arthroscopy |
| 巻 | 27巻 |
| 号 | 2号 |
| 出版者 | Springer |
| 開始ページ | 361 |
| 終了ページ | 368 |
| ISSN | 0942-2056 |
| NCID | AA10973641 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 30251100 |
| DOI | 10.1007/s00167-018-5157-2 |
| Web of Science KeyUT | 000460315200005 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00167-018-5157-2 |
| 著者 | Okazaki, Yuki| Furumatsu, Takayuki| Okazaki, Yoshiki| Masuda, Shin| Hiranaka, Takaaki| Kodama, Yuya| Kamatsuki, Yusuke| Miyazawa, Shinichi| Tetsunaga, Tomonori| Ozaki, Toshifumi| |
|---|---|
| キーワード | Magnetic resonance imaging Medial meniscus Meniscus extrusion Posterior root tear Three-dimensional assessment |
| 備考 | This fulltext is available in Feb. 2021.| |
| 発行日 | 2020-01-01 |
| 出版物タイトル | The Knee |
| 巻 | 27巻 |
| 号 | 1号 |
| 出版者 | Elsevier |
| 開始ページ | 132 |
| 終了ページ | 139 |
| ISSN | 09680160 |
| NCID | AA10996272 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 31882388 |
| DOI | 10.1016/j.knee.2019.09.005 |
| Web of Science KeyUT | 000519666300017 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.knee.2019.09.005 |
| 著者 | Okazaki, Yoshiki| Furumatsu, Takayuki| Yamauchi, Takatsugu| Okazaki, Yuki| Kamatsuki, Yusuke| Hiranaka, Takaaki| Kajiki, Yuya| Zhang, Ximing| Ozaki, Toshifumi| |
|---|---|
| キーワード | medial meniscus posterior root tear transtibial repair meniscal volume medial extrusion three-dimensional magnetic resonance imaging |
| 備考 | This fulltext is available in Apr. 2021.| |
| 発行日 | 2020-04-06 |
| 出版物タイトル | Knee Surgery, Sports Traumatology, Arthroscopy |
| 出版者 | Springer |
| ISSN | 09422056 |
| NCID | AA10973641 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 32253480 |
| DOI | 10.1007/s00167-020-05953-2 |
| Web of Science KeyUT | 000525297800001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00167-020-05953-2 |
| 著者 | Tetsunaga, Tomonori| Furumatsu, Takayuki| Abe, Nobuhiro| Nishida, Keiichiro| Naruse, Keiji| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2009-09-18 |
| 出版物タイトル | Journal of Biomechanics |
| 巻 | 42巻 |
| 号 | 13号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu| |
|---|---|
| 発行日 | 2011-06-03 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 409巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/49670 |
|---|---|
| フルテキストURL | 67_2_113.pdf |
| 著者 | Sugimoto, Yoshihisa| Tanaka, Masato| Gobara, Hideo| Misawa, Haruo| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| 抄録 | We report on 2 patients who experienced injury to one of their lumbar arteries related to pedicle screw misplacement. In this report, the lumbar pedicle screw holes were made laterally with resultant injury to the lumbar artery. During surgery, arterial bleeding was controlled with pressure and gauze; however, the patients experienced vital shock after surgery. Vital shock ensued and they were rescued by catheter embolization. If patients receiving lumbar instrumentation surgery experience severe anemia or vital shock postoperatively, the surgeon should assume lumbar artery injury as a differential diagnosis. |
| キーワード | catheter embolization complication lumbar artery injury pedicle screw |
| Amo Type | Case Report |
| 発行日 | 2013-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 67巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 113 |
| 終了ページ | 116 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23603928 |
| Web of Science KeyUT | 000317801700006 |
| JaLCDOI | 10.18926/AMO/53119 |
|---|---|
| フルテキストURL | 69_1_29.pdf |
| 著者 | Nakahara, Ryuichi| Nishida, Keiichiro| Hashizume, Kenzo| Harada, Ryouzou| Machida, Takahiro| Horita, Masahiro| Ohtsuka, Aiji| Ozaki, Toshifumi| |
| 抄録 | The outcome measures in rheumatology clinical trials (OMERACT) scores are the most mature quantitation system for rheumatoid arthritis (RA) on magnetic resonance imaging (MRI). Direct measuring techniques of synovial volume have been reported with good reproducibility, although few reports have demonstrated the changes of these measures in response to treatment. To assess these clinical responses, we evaluated the correlation of the changes of clinical activity score 28-joints disease activity score (DAS28-CRP) with the changes of OMERACT scores and with synovial volume measurements. Eight RA patients who were treated by biologic agents were examined with MRI of the dominant affected wrist and finger joints before and one year after the treatment. The total OMERACT score was reduced from 48.0 to 41.3, and synovial volume was reduced from 15.4 to 8.8 milliliters. Positive correlations were seen between the changes of DAS28-CRP and the changes of OMERACT synovitis score (r＝0.27), OMERACT total score (r＝0.43) and synovial volume (r＝0.30). Limited to synovium assessment, synovial volume showed a better correlation with DAS28-CRP than the OMERACT synovitis score. On the other hand, the OMERACT total score showed a higher correlation with DAS28-CRP than synovial volume, probably because the OMERACT total score includes scores for bone erosion and bone edema as well. |
| キーワード | magnetic resonance imaging rheumatoid arthritis outcome measures in rheumatology clinical trials scoring system direct volume measuring medical work station |
| Amo Type | Original Article |
| 発行日 | 2015-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 69巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 29 |
| 終了ページ | 35 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25703168 |
| Web of Science KeyUT | 000349740300003 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/53113 |
| JaLCDOI | 10.18926/AMO/30956 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Doi, Hideyuki| Nishida, Keiichiro| Yorimitsu, Masanori| Komiyama, Takamitsu| Kadota, Yasutaka| Tetsunaga, Tomonori| Yoshida, Aki| Kubota, Satoshi| Takigawa, Masaharu| Ozaki, Toshifumi| |
| 抄録 | <p>Mechanical stress plays a key role in the pathogenesis of cartilage destruction seen in osteoarthritis (OA). We investigated the effect of cyclic tensile stress (CTS) on the anabolic and catabolic gene expression of rat cultured normal chondrocytes using the Flexercell strain unit. The effects of interleukin (IL)-4, a chondroprotective cytokine, on the changes in gene expression induced by CTS were also investigated. CTS (7% elongation at 0.5 Hz) for 24 h did not affect the expression of aggrecan and type II collagen, whereas CTS significantly upregulated matrix metalloproteinase (MMP)-13 and cathepsin B mRNA expression by chondrocytes. IL-1beta expression was also signifi cantly upregulated by CTS up to 12 h. The upregulation of MMP-13 was observed at 3 h, which was earlier than that of IL-1beta. Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1beta expression. Our results suggest that IL-4 might have a therapeutic value in the treatment of OA by downregulation of mechanical stress-induced MMP-13 and cathepsin B expression by chondrocytes.</p> |
| キーワード | IL-4 MMP cathepsin B mechanical stress aggrecanase |
| Amo Type | Original Article |
| 発行日 | 2008-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 62巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 119 |
| 終了ページ | 126 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 18464888 |
| Web of Science KeyUT | 000255297600008 |
| フルテキストURL | OTSR105_1_107.pdf Fig.pdf |
|---|---|
| 著者 | Furumatsu, Takayuki| Okazaki, Yuki| Okazaki, Yoshiki| Hino, Tomohito| Kamatsuki, Yusuke| Masuda, Shin| Miyazawa, Shinichi| Nakata, Eiji| Hasei, Joe| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| キーワード | Descending knee motion Injury pattern Medial meniscus Posterior root tear Squatting |
| 発行日 | 2019-02-28 |
| 出版物タイトル | Orthopaedics & Traumatology: Surgery & Research |
| 巻 | 105巻 |
| 号 | 1号 |
| 出版者 | Elsevier |
| 開始ページ | 107 |
| 終了ページ | 111 |
| ISSN | 18770568 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 30442555 |
| DOI | 10.1016/j.otsr.2018.10.001 |
| Web of Science KeyUT | 000456541300018 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.otsr.2018.10.001 |
| JaLCDOI | 10.18926/AMO/40011 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Honda, Mitsugi| Arita, Seizaburo| Mitani, Shigeru| Takeda, Yoshihiro| Ozaki, Toshifumi| Inamura, Keiji| Kanazawa, Susumu| |
| 抄録 | Plain X-ray radiography is frequently used for the diagnosis of developmental dislocation of the hip (DDH). The aim of this study was to construct a diagnostic support system for DDH based on clinical findings obtained from the X-ray images of 154 female infants with confirmed diagnoses made by orthopedists. The data for these subjects were divided into 2 groups. The Min-Max method of nonlinear analysis was applied to the data from Group 1 to construct the diagnostic support system based on the measurement of 4 items in X-ray images:the outward displacement rate, upward displacement rate, OE angle, and alpha angle. This system was then applied to the data from Group 2, and the results were compared between the 2 groups to verify the reliability of the system. We obtained good results that matched the confirmed diagnoses of orthopedists with an accuracy of 85.9%. |
| キーワード | X-ray image developmental dislocation of the hip acetabular dysplasia radiographic findings nonlinear multivariate analysis infant hip joint diagnostic support system |
| Amo Type | Original Article |
| 発行日 | 2010-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 64巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 189 |
| 終了ページ | 196 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20596130 |
| Web of Science KeyUT | 000279094300005 |
| JaLCDOI | 10.18926/AMO/57957 |
|---|---|
| フルテキストURL | 74_1_77.pdf |
| 著者 | Endo, Hirosuke| Akazawa, Hirofumi| Yashiro, Masato| Yamada, Kazuki| Sanki, Tomoaki| Tetsunaga, Tomonori| Nishida, Keiichiro| Furumatsu, Takayuki| Ozaki, Toshifumi| |
| 抄録 | Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up. |
| キーワード | idiopathic chondrolysis hip joint medication bump arthroscopy |
| Amo Type | Case Report |
| 発行日 | 2020-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 74巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 77 |
| 終了ページ | 81 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32099253 |
| Web of Science KeyUT | 000516606200012 |
| NAID | 120006795624 |
| JaLCDOI | 10.18926/AMO/49259 |
|---|---|
| フルテキストURL | 67_1_65.pdf |
| 著者 | Sakata, Kenichiro| Furumatsu, Takayuki| Abe, Nobuhiro| Miyazawa, Shinichi| Sakoma, Yoshimasa| Ozaki, Toshifumi| |
| 抄録 | Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human osteoarthritis. We retrospectively investigated cartilage repairs after marrow stimulation for the treatment of large cartilage defects in osteoarthritic knees. Tissues were obtained from patients who underwent total knee arthroplasty (TKA) after arthroscopic marrow stimulation in medial compartmental osteoarthritis. Clinical findings and cartilage repair were assessed. Sections of medial femoral condyles were histologically investigated by safranin O staining and anti-type II collagen antibody. Marrow stimulation decreased the knee pain in the short term. However, varus leg alignment gradually progressed, and TKA conversions were required. The grade of cartilage repair was not improved. Marrow stimulations resulted in insufficient cartilage regeneration on medial femoral condyles. Safranin O-stained proteoglycans and type II collagen were observed in the deep zone of marrow-stimulated holes. This study demonstrated that marrow stimulation resulted in failed cartilage repair for the treatment of large cartilage defects in osteoarthritic knees. Our results suggest that arthroscopic marrow stimulation might not improve clinical symptoms for the long term in patients suffering large osteoarthritic cartilage defects. |
| キーワード | bone marrow stimulation microfracture subchondral drilling osteoarthritis of the knee cartilage repair |
| Amo Type | Case Report |
| 発行日 | 2013-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 65 |
| 終了ページ | 74 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439511 |
| Web of Science KeyUT | 000316829900009 |
| JaLCDOI | 10.18926/AMO/47262 |
|---|---|
| フルテキストURL | 65_6_369.pdf |
| 著者 | Terada, Chuji| Yoshida, Aki| Nasu, Yoshihisa| Mori, Shuji| Tomono, Yasuko| Tanaka, Masato| Takahashi, Hideo K.| Nishibori, Masahiro| Ozaki, Toshifumi| Nishida, Keiichiro| |
| 抄録 | We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade of cartilage destruction, and examined the role of HMGB-1 in the regulation of proinflammatory cytokine expression in chondrocytes. An immunohistochemical study demonstrated that total HMGB-1-positive cell ratios increase as the Osteoarthritis Research Society International (OARSI) histological grade increased. The population of cytoplasmic HMGB-1-positive chondrocytes was especially increased in the deep layers of higher-grade cartilage. The ratios and localization of receptors for advanced glycation end products (RAGE) expression by chondrocytes in Grade 2, 3, and 4 were significantly higher than those in Grade 1. In vitro stimulation with IL-1β, but not TNFα, significantly upregulated the expression of HMGB-1 mRNA by human OA chondrocytes. Both IL-1β and TNFα promoted the translocation of HMGB-1 from nuclei to cytoplasm. IL-1β and TNFα secretions were stimulated at higher levels of HMGB-1. The results of our study suggest the involvement of HMGB-1 in the pathogenesis of cartilage destruction in OA. |
| キーワード | HMGB-1 RAGE chondrocyte osteoarthritis cartilage |
| Amo Type | Original Article |
| 発行日 | 2011-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 369 |
| 終了ページ | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189477 |
| Web of Science KeyUT | 000298516900003 |
| JaLCDOI | 10.18926/AMO/32641 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Ozaki, Toshifumi| Inoue, Hajime| Taguchi, Kohji| Sugihara, Shinsuke| |
| 抄録 | <p>We compared gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enhanced T1-weighted images (T1-Gd) with the histopathological findings in 13 patients with bone or soft tissue sarcomas. Signal intensity of the viable tumor tissue was increased in T1-Gd in 92% of the patients. The necrotic or cystic areas in the tumor were not enhanced, rendering them distinctly. The degree of enhancement of the edematous area around the tumor was similar to or more marked than that of the tumor in 54% of the patients. Area showing inflammatory cells infiltration and edematous areas in the tumor tissue were also enhanced. Thus, the effect of preoperative chemotherapy in tumor tissues other than necrotic and cystic areas tended to be underestimated in T1-Gd. Its effect should be comprehensively evaluated based on not only T1-Gd but also T2-weighted images and findings of other imaging techniques.</p> |
| キーワード | gadolinium diethylenetriaminepentaacetic acid(DTPA) magnetic resonance(MR) bone neoplasms soft tissue neoplasms |
| Amo Type | Article |
| 発行日 | 1992-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 46巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 471 |
| 終了ページ | 477 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 1485542 |
| Web of Science KeyUT | A1992KE49600010 |
| JaLCDOI | 10.18926/AMO/53680 |
|---|---|
| フルテキストURL | 69_5_325.pdf |
| 著者 | Okada, Yoshiki| Endo, Hirosuke| Mitani, Shigeru| Fujiwara, Kazuo| Tetsunaga, Tomonori| Kagawa, Yohei| Fujii, Yosuke| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| 抄録 | Total hip arthroplasty (THA) is the most effective treatment for advanced or end-stage hip osteoarthritis. However, venous thromboembolism (VTE) remains one of its unresolved complications. We reviewed the records of 322 patients undergoing primary THA and investigated the efficacy of anticoagulant prophylaxis for VTE. Our study cohort consisted of 60 patients who received no anticoagulants, 100 patients who received a factor Xa inhibitor (fondaparinux), 100 patients who received low molecular weight heparin (enoxaparin), and 62 patients who selectively received no anticoagulant prophylaxis due to perioperative bleeding, weight, and/or hemoglobin concentration. Enhanced 64-slice multidetector row computed tomography was performed postoperatively for 7 days in all cases. The incidence of VTE in the four groups was 15%, 9.0%, 6.0%, and 6.4%, respectively. The incidence of VTE was significantly lower in the groups receiving anticoagulant prophylaxis and the group selectively receiving no anticoagulant prophylaxis than in the group receiving no anticoagulants. Complications of fondaparinux therapy included hepatic dysfunction in 4 cases (4.0%), minor bleeding in 2 cases (2.0%), persistent wound drainage in 3 cases (3.0%), and eruption in 1 case (1.0%). The complications of enoxaparin therapy were persistent wound drainage in 1 case (1.0%) and progression of anemia in 1 case (1.0%). The incidence of VTE was low in patients who selectively received no anticoagulant prophylaxis, so we conclude that anticoagulant prophylaxis should be used selectively in THA cases. |
| キーワード | total hip arthroplasty venous thromboembolism anticoagulant prophylaxis complications |
| Amo Type | Erratum |
| 発行日 | 2015-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 69巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 325 |
| 終了ページ | 325 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 26490031 |
| 関連URL | http://doi.org/10.18926/AMO/53556 |