フルテキストURL fulltext.pdf
著者 Yamamoto, Norio| Sukegawa, Shintaro| Yamashita, Kazutaka| Manabe, Masaki| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Ozaki, Toshifumi| Kawasaki, Keisuke| Nagatsuka, Hitoshi| Furuki, Yoshihiko| Yorifuji, Takashi|
キーワード patient variables osteoporosis deep learning convolutional neural network ensemble model effect size
発行日 2021-08-20
出版物タイトル Medicina-Lithuania
57巻
8号
出版者 MDPI
開始ページ 846
ISSN 1010-660X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 34441052
DOI 10.3390/medicina57080846
Web of Science KeyUT 000689547600001
関連URL isVersionOf https://doi.org/10.3390/medicina57080846
フルテキストURL fulltext.pdf
著者 Nakata, Eiji| Fujiwara, Tomohiro| Katayama, Haruyoshi| Itano, Takuto| Kunisada, Toshiyuki| Ozaki, Toshifumi|
キーワード malignant wounds soft tissue sarcoma microbiological analysis surgical site infection prognosis
発行日 2022-08-17
出版物タイトル Oncology Letters
24巻
4号
出版者 Spandidos Publications
開始ページ 345
ISSN 1792-1074
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © Nakata et al.
論文のバージョン publisher
PubMed ID 36072006
DOI 10.3892/ol.2022.13465
Web of Science KeyUT 000891420600001
関連URL isVersionOf https://doi.org/10.3892/ol.2022.13465
フルテキストURL fulltext.pdf
著者 Kawada, Koki| Furumatsu, Takayuki| Tamura, Masanori| Xue, Haowei| Higashihara, Naohiro| Kintaka, Keisuke| Yokoyama, Yusuke| Ozaki, Toshifumi|
発行日 2023-02
出版物タイトル Arthroscopy Techniques
12巻
2号
出版者 Elsevier
開始ページ e273
終了ページ e278
ISSN 2212-6287
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 THE AUTHORS.
論文のバージョン publisher
PubMed ID 36879867
DOI 10.1016/j.eats.2022.11.002
Web of Science KeyUT 000991859500001
関連URL isVersionOf https://doi.org/10.1016/j.eats.2022.11.002
著者 Kinami, Yo| Noda, Tomoyuki| Ozaki, Toshifumi|
発行日 2013-05
出版物タイトル Journal of Orthopaedic Science
18巻
3号
資料タイプ 学術雑誌論文
フルテキストURL fulltext.pdf
著者 Hirose, Kazuki| Kuwahara, Miho| Nakata, Eiji| Tetsunaga, Tomonori| Yamada, Kazuki| Saiga, Kenta| Takigawa, Masaharu| Ozaki, Toshifumi| Kubota, Satoshi| Hattori, Takako|
キーワード hip osteoarthritis cartilage cellular communication network factor 3 (CCN3) senescence-associatedsecretory phenotype (SASP) p16 ADAMTA4/5 IL-6 TNFa aging Mankinscore weight-bearing non-weight-bearing
発行日 2022-12-04
出版物タイトル International Journal Of Molecular Sciences
23巻
23号
出版者 MDPI
開始ページ 15311
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 36499638
DOI 10.3390/ijms232315311
Web of Science KeyUT 000897995800001
関連URL isVersionOf https://doi.org/10.3390/ijms232315311
フルテキストURL fulltext.pdf
著者 Hasei, Joe| Hanzawa, Mana| Nagano, Akihito| Maeda, Naoko| Yoshida, Shinichirou| Endo, Makoto| Yokoyama, Nobuhiko| Ochi, Motoharu| Ishida, Hisashi| Katayama, Hideki| Fujiwara, Tomohiro| Nakata, Eiji| Nakahara, Ryuichi| Kunisada, Toshiyuki| Tsukahara, Hirokazu| Ozaki, Toshifumi|
キーワード generative AI chatbot large language model pediatric cancer adolescent and young adult (AYA) psychological support
発行日 2025-02-25
出版物タイトル Frontiers in Digital Health
7巻
出版者 Frontiers Media
開始ページ 1543543
ISSN 2673-253X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2025 Hasei, Hanzawa, Nagano, Maeda, Yoshida, Endo, Yokoyama, Ochi, Ishida, Katayama, Fujiwara, Nakata, Nakahara, Kunisada, Tsukahara and Ozaki.
論文のバージョン publisher
PubMed ID 40070545
DOI 10.3389/fdgth.2025.1543543
Web of Science KeyUT 001441098700001
関連URL isVersionOf https://doi.org/10.3389/fdgth.2025.1543543
著者 Shiozaki, Yasuyuki| Kitajima, Takashi| Mazaki, Tetsuro| Yoshida, Aki| Tanaka, Masato| Umezawa, Akihiro| Nakamura, Mariko| Yoshida, Yasuhiro| Ito, Yoshihiro| Ozaki, Toshifumi| Matsukawa, Akihiro|
発行日 2013-04
出版物タイトル International Journal of Nanomedicine
8巻
1号
資料タイプ 学術雑誌論文
フルテキストURL fulltext20230703-01.pdf
著者 Kamatsuki, Yusuke| Furumatsu, Takayuki| Hiranaka, Takaaki| Okazaki, Yuki| Kintaka, Keisuke| Kodama, Yuya| Miyazawa, Shinichi| Ozaki, Toshifumi|
キーワード Body mass index Medial meniscus Painful popping Posterior root tear Pullout repair
備考 The version of record of this article, first published in International Orthopaedics, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00264-023-05848-0|
発行日 2023-06-17
出版物タイトル International Orthopaedics
47巻
10号
出版者 Springer Science and Business Media LLC
開始ページ 2537
終了ページ 2545
ISSN 0341-2695
NCID AA0068148X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2023
論文のバージョン publisher
PubMed ID 37329453
DOI 10.1007/s00264-023-05848-0
Web of Science KeyUT 001007187100001
関連URL isVersionOf https://doi.org/10.1007/s00264-023-05848-0
JaLCDOI 10.18926/AMO/40007
フルテキストURL fulltext.pdf
著者 Furumatsu, Takayuki| Ozaki, Toshifumi|
抄録 Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis.
キーワード epigenetics DNA methylation histone acetylation and HAT histone deacetylation and HDAC chondrogenesis
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2010-06
64巻
3号
出版者 Okayama University Medical School
開始ページ 155
終了ページ 161
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 20596126
Web of Science KeyUT 000279094300001
フルテキストURL fulltext.pdf
著者 Sato, Yoshihiro| Tetsunaga, Tomonori| Yamada, Kazuki| Kawamura, Yoshi| Yoshida, Aki| Ozaki, Toshifumi|
キーワード hip osteoarthritis (OA) acetabular labrum vascular endothelial growth factor (VEGF) nerve growth factor (NGF) immunochemical staining
発行日 2023-02-02
出版物タイトル International Journal Of Molecular Sciences
24巻
3号
出版者 MDPI
開始ページ 2926
ISSN 1422-0067
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 by the authors.
論文のバージョン publisher
PubMed ID 36769248
DOI 10.3390/ijms24032926
Web of Science KeyUT 000930101500001
関連URL isVersionOf https://doi.org/10.3390/ijms24032926
JaLCDOI 10.18926/AMO/30739
フルテキストURL fulltext.pdf
著者 Aiga, Ayako| Asaumi, Koji| Lee, You Jin| Kadota, Hiroaki| Mitani, Shigeru| Ozaki, Toshifumi| Takigawa, Masaharu|
抄録 The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation. After osteotomy, a 7-day lag phase was followed by distraction at the rate of 0.25 mm/12 h for 21 days (distraction phase), and a 7-day consolidation phase. The localization of neurotrophins (NGF, BDNF and NT-3) and their receptors tropomyosinrelated kinases (TRKA, TRKB and TRKC) by immunostaining showed positive staining in bone forming cells in each stage, although the presence and staining intensity varied by cell type and phase. The expressions of NGF, BDNF and NT-3 by real-time polymerase chain reaction (real-time PCR) showed that the peak of the mRNA expression of NGF occurred 10 days after distraction. NT-3 increased during bone extension, but decreased when distraction stopped. In contrast, BDNF continued to increase gradually throughout the distraction and consolidation phases. These findings suggest that neurotrophins and their receptors may play different roles in endochondral and intramembranous ossification in distraction osteogenesis. The tension stress caused by distraction may stimulate the expression of neurotrophins and their receptors, and promote osteogenesis.
キーワード neurotrophin Trk distraction osteogenesis mechanical stress
Amo Type Article
出版物タイトル Acta Medica Okayama
発行日 2006-10
60巻
5号
出版者 Okayama University Medical School
開始ページ 267
終了ページ 277
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
PubMed ID 17072373
Web of Science KeyUT 000241509000003
フルテキストURL AOTS20191023.pdf fig.pdf Table.pdf
著者 Yamamoto, Norio| Noda, Tomoyuki| Saito, Taichi| Uehara, Takenori| Shimamura, Yasunori| Ozaki, Toshifumi|
キーワード Acetabular fracture External iliac artery External iliac vein Ilioinguinal approach Occlusion Thrombosis
備考 This is a post-peer-review, pre-copyedit version of an article published in Archives of Orthopaedic and Trauma Surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00402-019-03288-3.|
発行日 2019-10-23
出版物タイトル Archives of Orthopaedic and Trauma Surgery
140巻
4号
出版者 Springer
開始ページ 481
終了ページ 485
ISSN 0936-8051
NCID AA10738765
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31642955
DOI 10.1007/s00402-019-03288-3
Web of Science KeyUT 000492001100001
関連URL isVersionOf https://doi.org/10.1007/s00402-019-03288-3
JaLCDOI 10.18926/AMO/67655
フルテキストURL 78_5_357.pdf
著者 Yamawaki, Ryoko| Oda, Yoshiaki| Yamane, Shuhei| Uotani, Koji| Misawa, Haruo| Katayama, Yoshimi| Hamada, Masanori| Ozaki, Toshifumi|
抄録 Research on postural control in patients with adolescent idiopathic scoliosis (AIS) has focused on static postural control, with few studies assessing dynamic postural control. We aimed to identify factors affecting index of postural stability (IPS), a dynamic postural control parameter, in patients with AIS. The participants comprised 50 female patients with AIS. We measured the IPS using stabilometry to evaluate dynamic postural control ability. We investigated age of the participants, major curve position (thoracic or thoracolumbar/lumbar), Cobb angle, and coronal balance. We then assessed the relationships between stabilometry parameters and other variables. IPS was analyzed with a linear regression model. Coronal balance, major curve position, and age each correlated with dynamic postural control ability. The Cobb angle showed no correlation with any of the parameters. Our results offer new insights into the assessment of postural control in patients with AIS.
キーワード adolescent idiopathic scoliosis postural control coronal balance index of postural stability stabilometry
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-10
78巻
5号
出版者 Okayama University Medical School
開始ページ 357
終了ページ 362
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 39467653
Web of Science KeyUT 001343346400001
フルテキストURL fulltext.pdf
著者 Akezaki, Yoshiteru| Nakata, Eiji| Kikuuchi, Masato| Sugihara, Shinsuke| Katayama, Yoshimi| Katayama, Haruki| Hamada, Masanori| Ozaki, Toshifumi|
キーワード quality of life spinal bone metastases radiotherapy activities of daily living pain
発行日 2021-11-03
出版物タイトル Healthcare
9巻
11号
出版者 MDPI
開始ページ 1499
ISSN 2227-9032
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 34828545
DOI 10.3390/healthcare9111499
Web of Science KeyUT 000726670300001
関連URL isVersionOf https://doi.org/10.3390/healthcare9111499
JaLCDOI 10.18926/AMO/52007
フルテキストURL 67_6_343.pdf
著者 Yamane, Kentaro| Takigawa, Tomoyuki| Tanaka, Masato| Osaki, Syuhei| Sugimoto, Yoshihisa| Ozaki, Toshifumi|
抄録 Cervical spinal schwannoma is benign, and outcomes after surgical resection are generally excellent. A surgical dilemma sometimes arises as to whether to perform total tumor removal, which carries a risk of sacrificing the nerve root, or subtotal removal, where the risk can be tumor recurrence. The purpose of this study was to identify factors with the potential to predict clinical impairment after surgery for cervical spinal schwannomas. Thirty cases of cervical schwannomas treated surgically in our institute were retrospectively reviewed;initial symptoms, tumor location, Eden classification, surgical method, functional outcome, and tumor recurrence were investigated. All permanent motor deficits were the result of resecting functionally relevant nerve roots (i.e., C5-8). The rate of permanent sensory deficit was 11% after C1-4 nerve root resection, and 67% after C5-8 nerve root resection. Permanent neurological deficits occurred in 14% of patients younger than 40 years and 38% of those older than 40. Dumbbell tumors were associated with the need for total or ventral nerve root transection, as well as with a high incidence of tumor recurrence. The incidence of permanent neurological deficit was significantly higher in patients undergoing C5-8 nerve root resection, and tended to be higher in those over 40.
キーワード cervical spinal schwannoma neurological deficit nerve root resection tumor resection tumor recurrence
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2013-12
67巻
6号
出版者 Okayama University Medical School
開始ページ 343
終了ページ 349
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 24356718
Web of Science KeyUT 000328915700002
フルテキストURL fulltext.pdf
著者 Tsuji, Hironori| Tetsunaga, Tomoko| Tetsunaga, Tomonori| Misawa, Haruo| Oda, Yoshiaki| Takao, Shinichiro| Nishida, Keiichiro| Ozaki, Toshifumi|
キーワード caregiver burden chronic pain fear-avoidance model self-efficacy Zarit Burden Interview
発行日 2022-09-30
出版物タイトル Medicine
101巻
39号
出版者 Lippincott Williams & Wilkins
開始ページ e30802
ISSN 0025-7974
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 the Author(s).
論文のバージョン publisher
PubMed ID 36181114
DOI 10.1097/MD.0000000000030802
Web of Science KeyUT 000862039900121
関連URL isVersionOf https://doi.org/10.1097/MD.0000000000030802
フルテキストURL fulltext.pdf
著者 Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi|
発行日 2024-02-20
出版物タイトル PLoS ONE
19巻
2号
出版者 Public Library of Science
開始ページ e0298292
ISSN 1932-6203
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 Uotani et al.
論文のバージョン publisher
PubMed ID 38377118
DOI 10.1371/journal.pone.0298292
Web of Science KeyUT 001176939600021
関連URL isVersionOf https://doi.org/10.1371/journal.pone.0298292
JaLCDOI 10.18926/AMO/53680
フルテキストURL 69_5_325.pdf
著者 Okada, Yoshiki| Endo, Hirosuke| Mitani, Shigeru| Fujiwara, Kazuo| Tetsunaga, Tomonori| Kagawa, Yohei| Fujii, Yosuke| Kunisada, Toshiyuki| Ozaki, Toshifumi|
抄録 Total hip arthroplasty (THA) is the most effective treatment for advanced or end-stage hip osteoarthritis. However, venous thromboembolism (VTE) remains one of its unresolved complications. We reviewed the records of 322 patients undergoing primary THA and investigated the efficacy of anticoagulant prophylaxis for VTE. Our study cohort consisted of 60 patients who received no anticoagulants, 100 patients who received a factor Xa inhibitor (fondaparinux), 100 patients who received low molecular weight heparin (enoxaparin), and 62 patients who selectively received no anticoagulant prophylaxis due to perioperative bleeding, weight, and/or hemoglobin concentration. Enhanced 64-slice multidetector row computed tomography was performed postoperatively for 7 days in all cases. The incidence of VTE in the four groups was 15%, 9.0%, 6.0%, and 6.4%, respectively. The incidence of VTE was significantly lower in the groups receiving anticoagulant prophylaxis and the group selectively receiving no anticoagulant prophylaxis than in the group receiving no anticoagulants. Complications of fondaparinux therapy included hepatic dysfunction in 4 cases (4.0%), minor bleeding in 2 cases (2.0%), persistent wound drainage in 3 cases (3.0%), and eruption in 1 case (1.0%). The complications of enoxaparin therapy were persistent wound drainage in 1 case (1.0%) and progression of anemia in 1 case (1.0%). The incidence of VTE was low in patients who selectively received no anticoagulant prophylaxis, so we conclude that anticoagulant prophylaxis should be used selectively in THA cases.
キーワード total hip arthroplasty venous thromboembolism anticoagulant prophylaxis complications
Amo Type Erratum
出版物タイトル Acta Medica Okayama
発行日 2015-10
69巻
5号
出版者 Okayama University Medical School
開始ページ 325
終了ページ 325
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26490031
関連URL http://doi.org/10.18926/AMO/53556
JaLCDOI 10.18926/AMO/65147
フルテキストURL 77_2_179.pdf
著者 Kondo, Hidenori| Saito, Taichi| Nakahara, Ryuichi| Nakamichi, Ryo| Shimamura, Yasunori| Harada, Ryozo| Imatani, Junya| Ozaki, Toshifumi|
抄録 Rupture of the extensor pollicis longus (EPL) tendon is a known complication after undisplaced distal radius fracture (DRF). However, no report has revealed the relationship between EPL tendon rupture and the fracture pattern. Thus, this study aimed to investigate the characteristics of fractures at risk of EPL tendon rupture using fracture line mapping of undisplaced DRFs. This study used computed tomography imaging data of undisplaced DRFs with (n=18) and without EPL tendon rupture (n=52). Fracture lines obtained from 3D reconstruction data were drawn manually after matching with a 2D template wrist model. Fracture maps represented the fracture line distribution by superimposing the fracture lines of all 70 patients. Heat maps showed the relative frequency of the fracture lines as a gradual color change. Fracture lines of cases with EPL tendon rupture were concentrated in the proximal border of Lister’s tubercle. By contrast, fracture lines of cases without EPL tendon rupture were relatively dispersed.
キーワード distal radius fracture rupture of extensor pollicis longus tendon fracture mapping
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-04
77巻
2号
出版者 Okayama University Medical School
開始ページ 179
終了ページ 184
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37094955
Web of Science KeyUT 000982503800007
JaLCDOI 10.18926/AMO/32641
フルテキストURL fulltext.pdf
著者 Ozaki, Toshifumi| Inoue, Hajime| Taguchi, Kohji| Sugihara, Shinsuke|
抄録

We compared gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enhanced T1-weighted images (T1-Gd) with the histopathological findings in 13 patients with bone or soft tissue sarcomas. Signal intensity of the viable tumor tissue was increased in T1-Gd in 92% of the patients. The necrotic or cystic areas in the tumor were not enhanced, rendering them distinctly. The degree of enhancement of the edematous area around the tumor was similar to or more marked than that of the tumor in 54% of the patients. Area showing inflammatory cells infiltration and edematous areas in the tumor tissue were also enhanced. Thus, the effect of preoperative chemotherapy in tumor tissues other than necrotic and cystic areas tended to be underestimated in T1-Gd. Its effect should be comprehensively evaluated based on not only T1-Gd but also T2-weighted images and findings of other imaging techniques.

キーワード gadolinium diethylenetriaminepentaacetic acid(DTPA) magnetic resonance(MR) bone neoplasms soft tissue neoplasms
Amo Type Article
出版物タイトル Acta Medica Okayama
発行日 1992-12
46巻
6号
出版者 Okayama University Medical School
開始ページ 471
終了ページ 477
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
PubMed ID 1485542
Web of Science KeyUT A1992KE49600010