検索結果 - 岡山大学学術成果リポジトリ

Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients with Type 2 Diabetes: A Multicenter Prospective Study with 5-year Follow up（U-CARE Study 2)

フルテキストURL	K0006448_abstract_review.pdf K0006448_fulltext.pdf
著者	今村麻理子\|
発行日	2021-09-24
資料タイプ	学位論文
学位授与番号	甲第6448号
学位授与年月日	2021-09-24
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	Copyright © 2021 Mise, Imamura, Yamaguchi, Watanabe, Higuchi, Katayama, Miyamoto, Uchida, Nakatsuka, Eguchi, Hida, Nakato, Tone, Teshigawara, Matsuoka, Kamei, Murakami, Shimizu, Miyashita, Ando, Nunoue, Yoshida, Yamada, Shikata and Wada.

VEGFR2 blockade augments the effects of TKIs by inhibiting angiogenesis and oncogenic signaling in NSCLCs

フルテキストURL	K0006438_abstract_review.pdf K0006438_fulltext.pdf
著者	渡邉洋美\|
発行日	2021-09-24
資料タイプ	学位論文
学位授与番号	甲第6438号
学位授与年月日	2021-09-24
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© 2021 The Authors

Clinical Efficacy and Safety of Sitafloxacin 200 mg Once Daily for Refractory Genitourinary Tract Infections

JaLCDOI	10.18926/AMO/62820
フルテキストURL	75_6_763.pdf
著者	Iwata, Takehiro\| Sadahira, Takuya\| Maruyama, Yuki\| Sekito, Takanori\| Yoshinaga, Kasumi\| Watari, Shogo\| Nagao, Kentaro\| Kawada, Tatsushi\| Tominaga, Yusuke\| Nishimura, Shingo\| Takamoto, Atsushi\| Sako, Tomoko\| Edamura, Kohei\| Kobayashi, Yasuyuki\| Araki, Motoo\| Ishii, Ayano\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\| Wada, Koichiro\|
抄録	The aim of this ongoing trial is to evaluate the clinical efficacy and safety of sitafloxacin (STFX) 200 mg once daily (QD) for 7 days in patients with refractory genitourinary tract infections, which include recurrent or complicated cystitis, complicated pyelonephritis, bacterial prostatitis, and epididymitis. The primary endpoint is the microbiological efficacy at 5-9 days after the last administration of STFX. Recruitment began in February 2021, and the target total sample size is 92 participants.
キーワード	genitourinary tract infections fluoroquinolone resistance extended-spectrum beta-lactamase
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	763
終了ページ	766
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955548
Web of Science KeyUT	000735319800006
NAID	120007180272

Multiple Hepatolithiasis Following Hepaticojejunostomy Successfully Treated with Left Hemihepatectomy and Double Hepaticojejunostomy Reconstruction

JaLCDOI	10.18926/AMO/62814
フルテキストURL	75_6_735.pdf
著者	Nagai, Yasuo\| Takagi, Kosei\| Kuise, Takashi\| Umeda, Yuzo\| Yoshida, Ryuichi\| Yoshida, Kazuhiro\| Yasui, Kazuya\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
抄録	Surgical intervention for hepatolithiasis following hepaticojejunostomy (HJ) has rarely been reported. Herein, we present a case of post-HJ multiple hepatolithiasis treated with left hemihepatectomy with double HJ reconstruction. A 72-year-old woman who had undergone HJ for iatrogenic bile duct injury developed repeated cholangitis due to complicated hepatolithiasis accompanied by an atrophied left hepatic lobe and HJ stricture. Since endoscopic intervention was unsuccessful, the patient underwent left hemihepatectomy with HJ re-anastomoses of the common hepatic duct and left hepatic duct (double HJ technique). The double HJ technique with hepatectomy can be a useful option for treating complicated hepatolithiasis following HJ.
キーワード	hepatolithiasis hepaticojejunostomy hepatectomy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	735
終了ページ	739
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955542
Web of Science KeyUT	000735297900009
NAID	120007180278

The Significance of Age and Causative Bacterial Morphology in the Choice of an Antimicrobial Agent to Treat Acute Uncomplicated Cystitis

JaLCDOI	10.18926/AMO/62812
フルテキストURL	75_6_719.pdf
著者	Uehara, Shinya\| Fujio, Kei\| Yamasaki, Tomoya\| Otsuki, Hideo\|
抄録	Differentiating patients by age and causative bacterial morphology might aid in making the appropriate choice of antimicrobial agent when treating acute uncomplicated cystitis. In this retrospective analysis, the non-susceptibility rates of the causative bacteria to cefcapene-pivoxil (CFPN-PI) and levofloxacin (LVFX) were determined after dividing patients with acute uncomplicated cystitis by age group (15-54 and 55-74 years old) and by bacterial morphology: gram-positive cocci (GPC) or gram-negative rod (GNR). The overall non-susceptibility rates for CFPN-PI and LVFX were 19.4% and 15.3%, respectively. When the subjects were divided by age, only the non-susceptibility rate for LVFX in the younger group significantly decreased (to 8.7%). When the groups were divided by both age and bacterial morphology, the younger GNR group had non-susceptibility rates of 6.9% to CFPN-PI and 7.8% to LVFX, whereas the younger GPC group showed 10.2% non-susceptibility to LVFX. The older GNR group showed 9.8% non-susceptibility to CFPN-PI, while the older GPC group showed 7.2% non-susceptibility to LVFX. All the non-susceptibility rates were lower than 10.2% in the sub-divided groups. Differentiating patients by age and the morphology of causative bacteria can aid in making the appropriate choice of antimicrobial agent and may improve treatment outcomes in patients with acute uncomplicated cystitis.
キーワード	acute uncomplicated cystitis oral antimicrobial agents antimicrobial susceptibility menopause Gram stain
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	719
終了ページ	724
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955540
Web of Science KeyUT	000735297900008
NAID	120007180280

Correlations Among Consistency, Computed Tomography Values, and Histopathological Subtypes of Spinal Meningioma

JaLCDOI	10.18926/AMO/62811
フルテキストURL	75_6_713.pdf
著者	Aoyama, Tatsuro\| Ogiwara, Toshihiro\| Ito, Kiyoshi\| Miyaoka, Yoshinari\| Fujii, Yu\| Hanaoka, Yoshiki\| Hasegawa, Takatoshi\| Watanabe, Gen\| Seguchi, Tatsuya\| Hongo, Kazuhiro\|
抄録	The consistency of spinal meningiomas is important to consider when performing tumor removal surgery. This study evaluated the correlations between spinal meningioma consistency and both preoperative computed tomography (CT) values and histopathological subtypes. Fifteen consecutive patients who underwent surgical resection of spinal meningioma at our institution were identified, and preoperative CT values and the signal intensity of T2-weighted magnetic resonance images of the tumor were determined retrospectively. The consistency of the spinal meningioma was defined based on the ultrasonic surgical aspirator output during tumor debulking. Patients were assigned to 2 groups: a soft group (n=4) and a hard group (n=11). The T2 signal intensity was significantly higher in the soft group than in the hard group (p=0.001). While the CT values were considerably higher in the hard group, the difference was not significant (p=0.19). Regarding the histopathological subtypes, psammomatous meningioma exhibited significantly higher CT values than meningothelial meningioma (p=0.019); however, there was a higher frequency of hard tumors in meningothelial meningioma cases than in psammomatous meningioma cases. Although neither robust correlations between tumor consistency and CT values nor a relationship between tumor consistency and histopathological subtype has been established, these results might help with the perioperative manegement of spinal tumors.
キーワード	calcification computed tomography psammoma body spinal meningioma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	713
終了ページ	718
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955539
Web of Science KeyUT	000735297900007
NAID	120007180281

Testosterone Recovery after Neoadjuvant Gonadotropin-Releasing Hormone Antagonist versus Agonist on Permanent Iodine-125 Seed Brachytherapy in Prostate Cancer Patients: A Propensity Score Analysis

JaLCDOI	10.18926/AMO/62810
フルテキストURL	75_6_705.pdf
著者	Iwata, Takehiro\| Maruyama, Yuki\| Kawada, Tatsushi\| Sadahira, Takuya\| Katayama, Satoshi\| Takamoto, Atsushi\| Sako, Tomoko\| Wada, Koichiro\| Edamura, Kohei\| Kobayashi, Yasuyuki\| Araki, Motoo\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\|
抄録	Optimal neoadjuvant hormone therapy (NHT) for reducing prostate cancer (PC) patients’ prostate volume pre-brachytherapy is controversial. We evaluated the differential impact of neoadjuvant gonadotropin-releasing hormone (GnRH) antagonist versus agonist on post-brachytherapy testosterone recovery in 112 patients treated pre-brachytherapy with NHT (GnRH antagonist, n=32; GnRH agonists, n=80) (Jan. 2007-June 2019). We assessed the effects of patient characteristics and a GnRH analogue on testosterone recovery with logistic regression and a propensity score analysis (PSA). There was no significant difference in the rate of testosterone recovery to normal levels (> 300 ng/dL) between the GnRH antagonist and agonists (p=0.07). The GnRH agonists induced a significantly more rapid testosterone recovery rate at 3 months post-brachytherapy versus the GnRH antagonist (p<0.0001); there was no difference in testosterone recovery at 12 months between the GnRH antagonist/agonists (p=0.8). In the multivariate analysis, no actor was associated with testosterone recovery. In the PSA, older age and higher body mass index (BMI) were significantly associated with longer testosterone recovery. Post-brachytherapy testosterone recovery was quicker with the neoadjuvant GnRH agonists than the antagonist, and the testosterone recovery rate was significantly associated with older age and higher BMI. Long-term follow-ups are needed to determine any differential effects of GnRH analogues on the quality of life of brachytherapy-treated PC patients.
キーワード	testosterone recovery GnRH antagonist GnRH agonist brachytherapy prostate cancer
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	705
終了ページ	711
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955538
Web of Science KeyUT	000735297900006
NAID	120007180282

Evaluation of Preoperative Magnetic Resonance Cholangiopancreatography in Acute Cholecystitis to Predict Technical Difficulties in Laparoscopic Cholecystectomy

JaLCDOI	10.18926/AMO/62807
フルテキストURL	75_6_685.pdf
著者	Yamashita, Mampei\| Kuroki, Tamotsu\| Hamada, Takashi\| Hirayama, Takanori\| Tokunaga, Takayuki\| Yamanouchi, Kosho\| Takeshita, Hiroaki\| Maeda, Shigeto\|
抄録	Magnetic resonance cholangiopancreatography (MRCP) is a non-invasive imaging technique that provides high-quality visualization of the biliary tree, including the gallbladder. This study aimed to evaluate the useful-ness of preoperative MRCP for acute cholecystitis in predicting technical difficulties during laparoscopic chole-cystectomy (LC). A total of 168 patients who underwent LC with preoperative MRCP were enrolled in this study. Patients were divided into two groups according to preoperative MRCP findings: the visualized group (n = 126), in which the entire gallbladder could be visualized; and the non-visualized group (n = 42), in which the entire gallbladder could not be visualized. The perioperative characteristics and postoperative complica-tions of the two groups were retrospectively analyzed. Operation time was longer in the non-visualized group (median 101.5 vs. 143.5 min; p < 0.001). The non-visualized group had significantly more intraoperative blood loss than the visualized group (median 5 vs. 10 g; p = 0.05). The rate of conversion to open cholecystectomy was significantly higher in the non-visualized group (1.6 vs. 9.5%; p = 0.03). In conclusion, patients in the non- visualized group showed higher difficulty in performance of LC. Our MRCP-based classification is a simple and effective means of predicting difficulties in performing LC for acute cholecystitis.
キーワード	laparoscopic cholecystectomy magnetic resonance cholangiopancreatography acute cholecystitis gallbladder disease non-invasive imaging
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	685
終了ページ	689
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955535
Web of Science KeyUT	000735297900003
NAID	120007180285

A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial

JaLCDOI	10.18926/AMO/62782
フルテキストURL	75_5_663.pdf
著者	Sadahira, Takuya\| Maruyama, Yuki\| Hiyama, Yoshiki\| Kitano, Hiroyuki\| Yamada, Hiroki\| Goto, Takayuki\| Kondo, Tsubasa\| Shigemura, Katsumi\| Mitsui, Yosuke\| Iwata, Takehiro\| Edamura, Kohei\| Araki, Motoo\| Watanabe, Masami\| Takenaka, Tadasu\| Teishima, Jun\| Miyata, Yasuyoshi\| Ishikawa, Kiyohito\| Takaoka, Ei-Ichiro\| Miyazaki, Jun\| Takahashi, Satoshi\| Masumori, Naoya\| Kiyota, Hiroshi\| Fujisawa, Masato\| Yamamoto, Shingo\| Sakuma, Takafumi\| Kusumi, Norihiro\| Ichikawa, Takaharu\| Watanabe, Toyohiko\| Nasu, Yoshitsugu\| Tsugawa, Masaya\| Nasu, Yasutomo\| Wada, Koichiro\|
抄録	The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants.
キーワード	antibiotic prophylaxis selective culture media prostate biopsy fluoroquinolone-resistant extended- spectrum beta-lactamase
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2021-10
巻	75巻
号	5号
出版者	Okayama University Medical School
開始ページ	663
終了ページ	667
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34703052
Web of Science KeyUT	000711568400007
NAID	120007166667

Relation Between Identity Disclosure to Family Members and Mental Health in Japanese Transgender People

JaLCDOI	10.18926/AMO/62774
フルテキストURL	75_5_611.pdf
著者	Zhou, Yu\| Furutani, Michiyo\| Athurupana, Rukmali\| Nakatsuka, Mikiya\|
抄録	Family members are critical mediators of the experiences of transgender people. We studied whether transgen-der subjects had disclosed their identity to their families and their families’ reactions after the disclosure. We also evaluated the subjects’ mental state and its association with disclosure status. Transgender people were recruited for this anonymous questionnaire survey in the Okayama University Hospital gender clinic. Subjects disclosed their identity to family members at the following rates: 68.7% to the father, 89.1% to the mother, 59.1% to a brother, 77.8% to a sister, and 47.6% to grandparents. Fathers had the lowest rate (26.7%) of posi-tive reactions, while over 50% of fathers showed an ambiguous response. Approximately 20% of parents showed a negative response. The majority of parents agreed to hormonal treatment and sex-reassignment sur-gery and that the transgender child should live with the gender they wanted to express. However, the rate of subjects with mood and anxiety disorders according to the Kessler 6 scale was significantly higher in those who experienced negative or ambiguous reactions from family members compared to those who experienced posi-tive reactions. Educational and mental health professionals should support the disclosure process of transgen-der people as well as their family members.
キーワード	disclosure family functioning gender nonconformity mental health transgender
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-10
巻	75巻
号	5号
出版者	Okayama University Medical School
開始ページ	611
終了ページ	623
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34703044
Web of Science KeyUT	000711561600008
NAID	120007166674

Clinical Manifestations of Patients with Influenza Differ by Age : A Prospective, Multi-centered Study in the Setouchi Marine Area

JaLCDOI	10.18926/AMO/62769
フルテキストURL	75_5_567.pdf
著者	Takase, Ryosuke\| Hagiya, Hideharu\| Honda, Hiroyuki\| Nakano, Yasuhiro\| Ogawa, Hiroko\| Obika, Mikako\| Ueda, Keigo\| Kataoka, Hitomi\| Hanayama, Yoshihisa\| Otsuka, Fumio\|
抄録	Influenza potentially has a high mortality rate when it affects the elderly. We aimed to examine the differences in clinical manifestations in patients with influenza according to their age. This multicenter prospective study was performed in six medical institutions in Okayama and Kagawa prefectures (Japan). Between December 1, 2019 and March 31, 2020, we collected data on adult patients diagnosed with influenza type A, who were strat-ified into younger (20-49 years), middle-aged (50-64 years), and older groups (≥ 65 years). We compared the presence or absence of fever, respiratory symptoms, and extrapulmonary symptoms according to age group. In total, 203 patients (113, younger; 51, middle-aged; and 39, older) were eligible for the analysis. The maxi-mum body temperature and temperature at first physician visit in the older group were significantly lower than those in the younger group. The incidence of respiratory symptoms was not different among the three groups. Chills, muscle pain, and arthralgia as systemic symptoms were noted significantly more frequently in the younger (80.9%) and middle-aged (75.5%) groups than in the older group (51.3%) (p = 0.002). Fever and sys-temic symptoms were less likely to appear in older patients, possibly resulting in the delaying of hospital visits among older adults.
キーワード	influenza, elderly fever respiratory symptom
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-10
巻	75巻
号	5号
出版者	Okayama University Medical School
開始ページ	567
終了ページ	574
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34703039
Web of Science KeyUT	000711561600003
NAID	120007166669

Spin-gap formation due to spin-Peierls instability in π-orbital-ordered NaO2

フルテキストURL	fulltext20211019-1.pdf
著者	Miyajima, Mizuki\| Astuti, Fahmi\| Fukuda, Takahito\| Kodani, Masashi\| Iida, Shinsuke\| Asai, Shinichiro\| Matsuo, Akira\| Masuda, Takatsugu\| Kindo, Koichi\| Hasegawa, Takumi\| Kobayashi, Tatsuo C.\| Nakano, Takehito\| Watanabe, Isao\| Kambe, Takashi\|
発行日	2021-10-7
出版物タイトル	Physical Review B
巻	104巻
号	14号
出版者	American Physical Society (APS)
開始ページ	L140402
ISSN	2469-9950
NCID	AA11187113
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2021 American Physical Society
論文のバージョン	publisher
DOI	10.1103/physrevb.104.l140402
Web of Science KeyUT	000704785600002
関連URL	isVersionOf https://doi.org/10.1103/physrevb.104.l140402

Longitudinal observation of insulin secretory ability before and after the onset of immune checkpoint inhibitor-induced diabetes mellitus: A report of two cases

フルテキストURL	fulltext.pdf
著者	Fujiwara, Noriko\| Watanabe, Mayu\| Katayama, Akihiro\| Noda, Yohei\| Eguchi, Jun\| Kataoka, Hitomi\| Kagawa, Shunsuke\| Wada, Jun\|
キーワード	C-peptide diabetes mellitus immune checkpoint inhibitor insulin secretion
発行日	2021-09-07
出版物タイトル	Clinical Case Reports
巻	9巻
号	9号
出版者	Wiley
開始ページ	e04574
ISSN	2050-0904
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	34522382
DOI	10.1002/ccr3.4574
Web of Science KeyUT	000700003300112
関連URL	isVersionOf https://doi.org/10.1002/ccr3.4574

Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms

フルテキストURL	fulltext20211018-7a.pdf
著者	Watari, Shogo\| Araki, Motoo\| Matsumoto, Jun\| Yoshinaga, Kasumi\| Sekito, Takanori\| Maruyama, Yuki\| Mitsui, Yosuke\| Sadahira, Takuya\| Kubota, Risa\| Nishimura, Shingo\| Wada, Koichiro\| Kobayashi, Yasuyuki\| Takeuchi, Hidemi\| Tanabe, Katsuyuki\| Kitagawa, Masashi\| Morinaga, Hiroshi\| Kitamura, Shinji\| Sugiyama, Hitoshi\| Ariyoshi, Noritaka\| Wada, Jun\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\|
キーワード	Cytochrome P450 tacrolimus renal transplantation CYP2C19 vonoprazan rabeprazole
備考	© 2021 The Japanese Society for the Study of Xenobiotics. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.dmpk.2021.100407] .\|
発行日	2021-10-31
出版物タイトル	Drug Metabolism and Pharmacokinetics
巻	40巻
出版者	Elsevier Ltd.
開始ページ	100407
ISSN	13474367
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.
論文のバージョン	author
PubMed ID	34352707
DOI	10.1016/j.dmpk.2021.100407
Web of Science KeyUT	000702719100002
関連URL	isVersionOf https://doi.org/10.1016/j.dmpk.2021.100407

A Retinoid X Receptor Agonist Directed to the Large Intestine Ameliorates T-Cell-Mediated Colitis in Mice

フルテキストURL	fulltext.pdf
著者	Matsumoto, Ryohtaroh\| Takahashi, Daisuke\| Watanabe, Masaki\| Nakatani, Shunsuke\| Takamura, Yuta\| Kurosaki, Yuji\| Kakuta, Hiroki\| Hase, Koji\|
キーワード	RXR NEt-3IB inflammatory bowel disease colitis Th1 cells
発行日	2021-08-12
出版物タイトル	Frontiers In Pharmacology
巻	12巻
出版者	Frontiers Media SA
開始ページ	715752
ISSN	1663-9812
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Matsumoto, Takahashi, Watanabe, Nakatani, Takamura,Kurosaki, Kakuta and Hase.
論文のバージョン	publisher
PubMed ID	34475823
DOI	10.3389/fphar.2021.715752
Web of Science KeyUT	000693889000001
関連URL	isVersionOf https://doi.org/10.3389/fphar.2021.715752

An Elderly Male with Primary Sjögren’s Syndrome Presenting Pleuritis as the Initial Manifestation

JaLCDOI	10.18926/AMO/62409
フルテキストURL	75_4_539.pdf
著者	Yamamoto, Yukichika\| Otsuka, Yuki\| Katsuyama, Takayuki\| Nishimura, Yoshito\| Oka, Kosuke\| Hasegawa, Kou\| Hagiya, Hideharu\| Otsuka, Fumio\|
抄録	Primary Sjögren’s syndrome (SS) is an autoimmune disease that usually affects the exocrine glands in mid-dle-aged women. Fifteen percent of SS patients experience severe systemic extraglandular complications, and pleuritis is one of the rare complications of SS. We report the case of an elderly Japanese man who initially pre-sented with a prolonged fever and chest pain and was finally diagnosed with primary SS-associated pleuritis. Of the nine reported cases of primary SS that initially presented with pleuritis, up to six cases were elderly males. This case highlights the complication of pleuritis among elderly males with primary SS.
キーワード	Sjögren’s syndrome pleuritis elderly male
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	539
終了ページ	542
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511624
Web of Science KeyUT	000696755800003
NAID	120007146035

Laparoscopic Synchronous Resection for Descending Colon Cancer and Tailgut Cyst

JaLCDOI	10.18926/AMO/62407
フルテキストURL	75_4_529.pdf
著者	Inada, Ryo\| Watanabe, Ayako\| Toshima, Toshiaki\| Katsura, Yuki\| Sato, Takuji\| Sui, Kenta\| Oishi, Kazuyuki\| Okabayashi, Takehiro\| Ozaki, Kazuhide\| Shibuya, Yuichi\| Matsumoto, Manabu\| Iwata, Jun\|
抄録	A 67-year-old woman underwent polypectomy for a tumor at the descending colon. Pathologically, the tumor was diagnosed as adenocarcinoma with an invasion of 2000 μm. Computed tomography showed a swollen paracolic lymph node and a mass lesion in the presacral space. Magnetic resonance imaging revealed a multio-cular cystic lesion. On diagnosis of descending colon cancer and tailgut cyst, she underwent synchronous lapa-roscopic resection. Histopathologically, the colon cancer was diagnosed as pT1bN1M0, pStage IIIa. The pre-sacral cystic lesion was diagnosed as a nonmalignant tailgut cyst with negative surgical margin. The patient is currently doing well without recurrence at 28 months.
キーワード	anterior approach laparoscopic resection tailgut cyst
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	529
終了ページ	532
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511622
Web of Science KeyUT	000696755800001
NAID	120007146033

Association Between Eosinophilia and Late-onset Circulatory Collapse in Preterm Infants: A case-Control Study

JaLCDOI	10.18926/AMO/62403
フルテキストURL	75_4_505.pdf
著者	Okamura, Tomoka\| Washio, Yosuke\| Watanabe, Hirokazu\| Nakanishi, Hidehiko\| Uchiyama, Atsushi\| Tsukahara, Hirokazu\| Kusuda, Satoshi\|
抄録	Late-onset circulatory collapse (LCC) in preterm infants is presumably caused by relative adrenal insufficiency. Because eosinophilia is known to be associated with adrenal insufficiency, we attempted to clarify the relation-ship between eosinophilia and LCC in preterm infants. We divided the cases of the infants (born at < 28 weeks’ gestation) admitted to our neonatal intensive care unit in 2008-2010 into 2 groups: those diagnosed with LCC that received glucocorticoids (LCC group), and those who did not receive glucocorticoids (control group). We compared eosinophil counts between the 2 groups and between before and after glucocorticoid treatment in the LCC group. A total of 28 infants were examined: LCC group (n = 12); control group (n = 16). The peak eosin-ophil counts of the LCC group were significantly higher than those of the control group (median: 1.392 × 109/L vs. 1.033 × 109/L, respectively; p = 0.02). Additionally, in the LCC group, the eosinophil counts declined significantly after glucocorticoid treatment (0.877 × 109/L vs. 0.271 × 109/L, p = 0.003). Eosinophil counts in the LCC group were significantly higher than in the control group and decreased rapidly after gluco-corticoid treatment. These results indicate that eosinophilia may be a factor associated with LCC caused by adrenal insufficiency.
キーワード	late-onset circulatory collapse preterm infant eosinophilia steroid adrenal insufficiency
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	505
終了ページ	509
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511618
Web of Science KeyUT	000709282300004
NAID	120007146046

Bendamustine Plus Rituximab as Salvage Treatment for Patients with Relapsed or Refractory Low-grade B-cell Lymphoma and Mantle Cell Lymphoma: A Single-Center Retrospective Study

JaLCDOI	10.18926/AMO/62398
フルテキストURL	75_4_461.pdf
著者	Murakami, Hiroyuki\| Yoshioka, Takanori\| Moriyama, Takashi\| Ishikawa, Tatsunori\| Makita, Masanori\| Sunami, Kazutaka\|
抄録	Bendamustine plus rituximab (B-R) is an effective therapy for relapsed or refractory (r/r) low-grade B-cell lymphoma (LGBCL) and mantle cell lymphoma (MCL); however, clinical data from Japanese patients treated with B-R therapy are limited. We retrospectively evaluated the efficacy and safety of B-R therapy in 42 patients who received B-R therapy at our hospital for r/r LGBCL and MCL. All patients received intravenous (IV) ritux-imab 375 mg/m2 on day 1 and IV bendamustine 90 mg/m2 on days 2 and 3 every 28 days for up to 6 cycles. The common histologic subtypes were follicular lymphoma (n = 29, 70%), marginal zone lymphoma (n = 6, 14%), and MCL (n = 5, 12%). The overall response rate was 93%, with 62% complete response and complete response unconfirmed. The median progression-free survival (PFS) was 38 months (95% confidence interval [CI], 24.6 to not reached [NR]), and the median overall survival (OS) was 80 months (95% CI, 60.7 to NR). Patients receiving a cumulative dose of bendamustine ≥ 720 mg/m2 showed a significantly longer PFS and OS. Grade 3/4 adverse events (≥ 10%) included neutropenia (55%), lymphopenia (69%), and nausea (24%). B-R therapy was effective and well tolerated, and the cumulative dose of bendamustine was associated with a favorable outcome.
キーワード	bendamustine low grade B-cell lymphoma mantle cell lymphoma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	461
終了ページ	469
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511613
Web of Science KeyUT	000697944600008
NAID	120007146041

The Cell Cycle Checkpoint Gene, RAD17 rs1045051, Is Associated with Prostate Cancer Risk

JaLCDOI	10.18926/AMO/62379
フルテキストURL	75_4_415.pdf
著者	Sun, Jingkai\| Lin, Wenfeng\| Wang, Qixu\| Sakai, Akiko\| Xue, Ruizhi\| Watanabe, Masami\| Liu, Chunxiao\| Sadahira, Takuya\| Nasu, Yasutomo\| Xu, Abai\| Huang, Peng\|
抄録	Human RAD17, as an agonist of checkpoint signaling, plays an essential role in mediating DNA damage. This hospital-based case-control study aimed to explore the association between RAD17 rs1045051, a missense sin-gle nucleotide polymorphism (SNP), and prostate cancer risk. Subjects were 358 prostate cancer patients and 314 cancer-free urology patients undergoing treatment at the Zhujiang Hospital of Southern Medical University in China. RAD17 gene polymorphism rs1045051 was evaluated by the SNaPshot method. Compared with the RAD17 gene polymorphism rs1045051 AA genotype, there was a higher risk of prostate cancer for the CC gen-otype (adjusted odds ratio [AOR] = 1.731, 95% confidence interval [95%CI] = 1.031−2.908, p = 0.038). Compared with the A allele, the C allele was significantly associated with the disease status (AOR = 1.302, 95%CI = 1.037−1.634, p = 0.023). All these findings indicate that in the SNP rs1045051, both the CC genotype and C allele may have a substantial influence on the prostate cancer risk.
キーワード	prostate cancer single-nucleotide polymorphisms cell cycle checkpoint rs1045051 RAD17
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	415
終了ページ	421
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511607
Web of Science KeyUT	000697944600002
NAID	120007146060