result 940 件
| FullText URL | K0006448_abstract_review.pdf K0006448_fulltext.pdf |
|---|---|
| Author | Imamura, Mariko| |
| Published Date | 2021-09-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6448号 |
| Granted Date | 2021-09-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | Copyright © 2021 Mise, Imamura, Yamaguchi, Watanabe, Higuchi, Katayama, Miyamoto, Uchida, Nakatsuka, Eguchi, Hida, Nakato, Tone, Teshigawara, Matsuoka, Kamei, Murakami, Shimizu, Miyashita, Ando, Nunoue, Yoshida, Yamada, Shikata and Wada. |
| FullText URL | K0006438_abstract_review.pdf K0006438_fulltext.pdf |
|---|---|
| Author | Watanabe, Hiromi| |
| Published Date | 2021-09-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6438号 |
| Granted Date | 2021-09-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2021 The Authors |
| JaLCDOI | 10.18926/AMO/62820 |
|---|---|
| FullText URL | 75_6_763.pdf |
| Author | Iwata, Takehiro| Sadahira, Takuya| Maruyama, Yuki| Sekito, Takanori| Yoshinaga, Kasumi| Watari, Shogo| Nagao, Kentaro| Kawada, Tatsushi| Tominaga, Yusuke| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Araki, Motoo| Ishii, Ayano| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| Wada, Koichiro| |
| Abstract | The aim of this ongoing trial is to evaluate the clinical efficacy and safety of sitafloxacin (STFX) 200 mg once daily (QD) for 7 days in patients with refractory genitourinary tract infections, which include recurrent or complicated cystitis, complicated pyelonephritis, bacterial prostatitis, and epididymitis. The primary endpoint is the microbiological efficacy at 5-9 days after the last administration of STFX. Recruitment began in February 2021, and the target total sample size is 92 participants. |
| Keywords | genitourinary tract infections fluoroquinolone resistance extended-spectrum beta-lactamase |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 763 |
| End Page | 766 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955548 |
| Web of Science KeyUT | 000735319800006 |
| NAID | 120007180272 |
| JaLCDOI | 10.18926/AMO/62814 |
|---|---|
| FullText URL | 75_6_735.pdf |
| Author | Nagai, Yasuo| Takagi, Kosei| Kuise, Takashi| Umeda, Yuzo| Yoshida, Ryuichi| Yoshida, Kazuhiro| Yasui, Kazuya| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Abstract | Surgical intervention for hepatolithiasis following hepaticojejunostomy (HJ) has rarely been reported. Herein, we present a case of post-HJ multiple hepatolithiasis treated with left hemihepatectomy with double HJ reconstruction. A 72-year-old woman who had undergone HJ for iatrogenic bile duct injury developed repeated cholangitis due to complicated hepatolithiasis accompanied by an atrophied left hepatic lobe and HJ stricture. Since endoscopic intervention was unsuccessful, the patient underwent left hemihepatectomy with HJ re-anastomoses of the common hepatic duct and left hepatic duct (double HJ technique). The double HJ technique with hepatectomy can be a useful option for treating complicated hepatolithiasis following HJ. |
| Keywords | hepatolithiasis hepaticojejunostomy hepatectomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 735 |
| End Page | 739 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955542 |
| Web of Science KeyUT | 000735297900009 |
| NAID | 120007180278 |
| reference | Cheon YK, Cho YD, Moon JH, Lee JS and Shim CS: Evaluation of long-term results and recurrent factors after operative and nonoperative treatment for hepatolithiasis. Surgery (2009) 146: 843- 853.| Lorio E, Patel P, Rosenkranz L, Patel S and Sayana H: Management of Hepatolithiasis: Review of the Literature. Curr Gastroenterol Rep (2020) 22: 30.| Ishihara Y, Matsumoto K, Kato H, Tsutsumi K, Tomoda T, Matsumi A, Miyamoto K, Yamazaki T, Saragai Y, Fujii Y, Uchida D, Horiguchi S and Okada H: Treatment outcomes, including risk factors of stone recurrence, for hepatolithiasis using balloon-assisted endoscopy in patients with hepaticojejunostomy (with video). Surg Endosc (2021) 35: 1895-1902.| Todani T, Watanabe Y, Toki A, Urushihara N and Sato Y: Reoperation for congenital choledochal cyst. Ann Surg (1988) 207: 142-147.| Ohi R, Yaoita S, Kamiyama T, Ibrahim M, Hayashi Y and Chiba T: Surgical treatment of congenital dilatation of the bile duct with special reference to late complications after total excisional operation. J Pediatr Surg (1990) 25: 613-617.| Suzuki Y, Mori T, Yokoyama M, Nakazato T, Abe N, Nakanuma Y, Tsubouchi H and Sugiyama M: Hepatolithiasis: analysis of Japanese nationwide surveys over a period of 40 years. J Hepatobiliary Pancreat Sci (2014) 21: 617-622.| Tazuma S, Unno M, Igarashi Y, Inui K, Uchiyama K, Kai M, Tsuyuguchi T, Maguchi H, Mori T, Yamaguchi K, Ryozawa S, Nimura Y, Fujita N, Kubota K, Shoda J, Tabata M, Mine T, Sugano K, Watanabe M and Shimosegawa T: Evidence-based clinical practice guidelines for cholelithiasis 2016. J Gastroenterol (2017) 52: 276-300.| Tabrizian P, Jibara G, Shrager B, Schwartz ME and Roayaie S: Hepatic resection for primary hepatolithiasis: a single-center Western experience. J Am Coll Surg (2012) 215: 622-626.| Feng X, Zheng S, Xia F, Ma K, Wang S, Bie P and Dong J: Classification and management of hepatolithiasis: A high-volume, single-centerʼs experience. Intractable Rare Dis Res (2012) 1: 151-156.| Li C and Wen T: Surgical management of hepatolithiasis: A minireview. Intractable Rare Dis Res (2017) 6: 102-105.| |
| JaLCDOI | 10.18926/AMO/62812 |
|---|---|
| FullText URL | 75_6_719.pdf |
| Author | Uehara, Shinya| Fujio, Kei| Yamasaki, Tomoya| Otsuki, Hideo| |
| Abstract | Differentiating patients by age and causative bacterial morphology might aid in making the appropriate choice of antimicrobial agent when treating acute uncomplicated cystitis. In this retrospective analysis, the non-susceptibility rates of the causative bacteria to cefcapene-pivoxil (CFPN-PI) and levofloxacin (LVFX) were determined after dividing patients with acute uncomplicated cystitis by age group (15-54 and 55-74 years old) and by bacterial morphology: gram-positive cocci (GPC) or gram-negative rod (GNR). The overall non-susceptibility rates for CFPN-PI and LVFX were 19.4% and 15.3%, respectively. When the subjects were divided by age, only the non-susceptibility rate for LVFX in the younger group significantly decreased (to 8.7%). When the groups were divided by both age and bacterial morphology, the younger GNR group had non-susceptibility rates of 6.9% to CFPN-PI and 7.8% to LVFX, whereas the younger GPC group showed 10.2% non-susceptibility to LVFX. The older GNR group showed 9.8% non-susceptibility to CFPN-PI, while the older GPC group showed 7.2% non-susceptibility to LVFX. All the non-susceptibility rates were lower than 10.2% in the sub-divided groups. Differentiating patients by age and the morphology of causative bacteria can aid in making the appropriate choice of antimicrobial agent and may improve treatment outcomes in patients with acute uncomplicated cystitis. |
| Keywords | acute uncomplicated cystitis oral antimicrobial agents antimicrobial susceptibility menopause Gram stain |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 719 |
| End Page | 724 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955540 |
| Web of Science KeyUT | 000735297900008 |
| NAID | 120007180280 |
| JaLCDOI | 10.18926/AMO/62811 |
|---|---|
| FullText URL | 75_6_713.pdf |
| Author | Aoyama, Tatsuro| Ogiwara, Toshihiro| Ito, Kiyoshi| Miyaoka, Yoshinari| Fujii, Yu| Hanaoka, Yoshiki| Hasegawa, Takatoshi| Watanabe, Gen| Seguchi, Tatsuya| Hongo, Kazuhiro| |
| Abstract | The consistency of spinal meningiomas is important to consider when performing tumor removal surgery. This study evaluated the correlations between spinal meningioma consistency and both preoperative computed tomography (CT) values and histopathological subtypes. Fifteen consecutive patients who underwent surgical resection of spinal meningioma at our institution were identified, and preoperative CT values and the signal intensity of T2-weighted magnetic resonance images of the tumor were determined retrospectively. The consistency of the spinal meningioma was defined based on the ultrasonic surgical aspirator output during tumor debulking. Patients were assigned to 2 groups: a soft group (n=4) and a hard group (n=11). The T2 signal intensity was significantly higher in the soft group than in the hard group (p=0.001). While the CT values were considerably higher in the hard group, the difference was not significant (p=0.19). Regarding the histopathological subtypes, psammomatous meningioma exhibited significantly higher CT values than meningothelial meningioma (p=0.019); however, there was a higher frequency of hard tumors in meningothelial meningioma cases than in psammomatous meningioma cases. Although neither robust correlations between tumor consistency and CT values nor a relationship between tumor consistency and histopathological subtype has been established, these results might help with the perioperative manegement of spinal tumors. |
| Keywords | calcification computed tomography psammoma body spinal meningioma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 713 |
| End Page | 718 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955539 |
| Web of Science KeyUT | 000735297900007 |
| NAID | 120007180281 |
| JaLCDOI | 10.18926/AMO/62810 |
|---|---|
| FullText URL | 75_6_705.pdf |
| Author | Iwata, Takehiro| Maruyama, Yuki| Kawada, Tatsushi| Sadahira, Takuya| Katayama, Satoshi| Takamoto, Atsushi| Sako, Tomoko| Wada, Koichiro| Edamura, Kohei| Kobayashi, Yasuyuki| Araki, Motoo| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | Optimal neoadjuvant hormone therapy (NHT) for reducing prostate cancer (PC) patients’ prostate volume pre-brachytherapy is controversial. We evaluated the differential impact of neoadjuvant gonadotropin-releasing hormone (GnRH) antagonist versus agonist on post-brachytherapy testosterone recovery in 112 patients treated pre-brachytherapy with NHT (GnRH antagonist, n=32; GnRH agonists, n=80) (Jan. 2007-June 2019). We assessed the effects of patient characteristics and a GnRH analogue on testosterone recovery with logistic regression and a propensity score analysis (PSA). There was no significant difference in the rate of testosterone recovery to normal levels (> 300 ng/dL) between the GnRH antagonist and agonists (p=0.07). The GnRH agonists induced a significantly more rapid testosterone recovery rate at 3 months post-brachytherapy versus the GnRH antagonist (p<0.0001); there was no difference in testosterone recovery at 12 months between the GnRH antagonist/agonists (p=0.8). In the multivariate analysis, no actor was associated with testosterone recovery. In the PSA, older age and higher body mass index (BMI) were significantly associated with longer testosterone recovery. Post-brachytherapy testosterone recovery was quicker with the neoadjuvant GnRH agonists than the antagonist, and the testosterone recovery rate was significantly associated with older age and higher BMI. Long-term follow-ups are needed to determine any differential effects of GnRH analogues on the quality of life of brachytherapy-treated PC patients. |
| Keywords | testosterone recovery GnRH antagonist GnRH agonist brachytherapy prostate cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 705 |
| End Page | 711 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955538 |
| Web of Science KeyUT | 000735297900006 |
| NAID | 120007180282 |
| JaLCDOI | 10.18926/AMO/62807 |
|---|---|
| FullText URL | 75_6_685.pdf |
| Author | Yamashita, Mampei| Kuroki, Tamotsu| Hamada, Takashi| Hirayama, Takanori| Tokunaga, Takayuki| Yamanouchi, Kosho| Takeshita, Hiroaki| Maeda, Shigeto| |
| Abstract | Magnetic resonance cholangiopancreatography (MRCP) is a non-invasive imaging technique that provides high-quality visualization of the biliary tree, including the gallbladder. This study aimed to evaluate the useful-ness of preoperative MRCP for acute cholecystitis in predicting technical difficulties during laparoscopic chole-cystectomy (LC). A total of 168 patients who underwent LC with preoperative MRCP were enrolled in this study. Patients were divided into two groups according to preoperative MRCP findings: the visualized group (n = 126), in which the entire gallbladder could be visualized; and the non-visualized group (n = 42), in which the entire gallbladder could not be visualized. The perioperative characteristics and postoperative complica-tions of the two groups were retrospectively analyzed. Operation time was longer in the non-visualized group (median 101.5 vs. 143.5 min; p < 0.001). The non-visualized group had significantly more intraoperative blood loss than the visualized group (median 5 vs. 10 g; p = 0.05). The rate of conversion to open cholecystectomy was significantly higher in the non-visualized group (1.6 vs. 9.5%; p = 0.03). In conclusion, patients in the non- visualized group showed higher difficulty in performance of LC. Our MRCP-based classification is a simple and effective means of predicting difficulties in performing LC for acute cholecystitis. |
| Keywords | laparoscopic cholecystectomy magnetic resonance cholangiopancreatography acute cholecystitis gallbladder disease non-invasive imaging |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 685 |
| End Page | 689 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955535 |
| Web of Science KeyUT | 000735297900003 |
| NAID | 120007180285 |
| JaLCDOI | 10.18926/AMO/62782 |
|---|---|
| FullText URL | 75_5_663.pdf |
| Author | Sadahira, Takuya| Maruyama, Yuki| Hiyama, Yoshiki| Kitano, Hiroyuki| Yamada, Hiroki| Goto, Takayuki| Kondo, Tsubasa| Shigemura, Katsumi| Mitsui, Yosuke| Iwata, Takehiro| Edamura, Kohei| Araki, Motoo| Watanabe, Masami| Takenaka, Tadasu| Teishima, Jun| Miyata, Yasuyoshi| Ishikawa, Kiyohito| Takaoka, Ei-Ichiro| Miyazaki, Jun| Takahashi, Satoshi| Masumori, Naoya| Kiyota, Hiroshi| Fujisawa, Masato| Yamamoto, Shingo| Sakuma, Takafumi| Kusumi, Norihiro| Ichikawa, Takaharu| Watanabe, Toyohiko| Nasu, Yoshitsugu| Tsugawa, Masaya| Nasu, Yasutomo| Wada, Koichiro| |
| Abstract | The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants. |
| Keywords | antibiotic prophylaxis selective culture media prostate biopsy fluoroquinolone-resistant extended- spectrum beta-lactamase |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 663 |
| End Page | 667 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703052 |
| Web of Science KeyUT | 000711568400007 |
| NAID | 120007166667 |
| reference | Liss M, Chang A, Santos R, Nakama-Peeples A, Peterson EM, Osann K, Billimek J, Szabo RJ and A Dash: Prevalence and significance of fluoroquinolone resistant Escherichia coli in patients undergoing transrectal ultrasound guided prostate needle biopsy. J Urol (2011) 185: 1283-1288.| Loeb S, Cater HB, Berndt SI, Richer W and Schaeffer EM: Complications after prostate biopsy: data from SEERMedicare. J Urol (2011) 186: 1830-1834.| Guidelines on urological infections. Eur Assoc Urol (2015) 50-58.| Best practice policy statement on urologic surgery antimicrobial prophylaxis. Am Urol Assoc (2014) 1-45.| Yamamoto S, Shigemura K, Kiyota H, Wada K, Hayami H, Yasuda M, Takahashi S, Ishikawa K, Hamasuna R, Arakawa S and T Matsumoto: Japanese Research Group for UTI: Essential Japanese guidelines for the prevention of perioperative infections in the urological field: 2015 edition. Int J Urol (2016) 23: 814-824.| Batura D, Rao GG and Nielson PB: Prevalence of antimicrobial resistance in intestinal flora of patients undergoing prostatic biopsy: implications for prophylaxis and treatment infections after biopsy. BJU Int (2010) 106: 1017-1020.| Sadahira T, Wada K, Araki M, Ishii A, Watanabe T, Nasu Y, Tsugawa M, Takenaka T, Nasu Y and Kumon H: Impact of selective media for detecting fluoroquinolone-insusceptible/extended- spectrum beta-lactamase-producing Escherichia coli before transrectal prostate biopsy. Int J Urol (2017) 24: 842-847.| Liss MA, Peeples AN and Peterson EM: Detection of fluoroquinolone- resistant organisms from rectal swabs by use of selective media prior to a transrectal prostate biopsy. J Clin Microbiol (2010) 49: 1116-1118.| Singh P, Kumar A, Yadav S, Prakash L, Nayak B, Kumar R, Kapil A and Dogra PN: “Targeted” prophylaxis: Impact of rectal swab culture-directed prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy. Investig Clin Urol (2017) 58: 365-370.| Yasuda M, Nakane K, Yamada Y, Matsumoto M, Sho T, Matsumoto M, Kobayashi K, Shigemura K, Nakano Y, Tanaka K, Hamasuna R, Ishihara S, Arakawa S, Yamamoto S, Matsubara A, Fujisawa M, Deguchi T and Matsumoto T: Clinical effectiveness and safety of tazobactam/piperacillin 4.5 g for the prevention of febrile infectious complication after prostate biopsy. J Infect Chemother (2014) 20: 631-634.| Ohkusu K: Cost-effective and rapid presumptive identification of gram-negative bacilli in routine urine, pus, and stool cultures: evaluation of the use of CHROMagar orientation medium in conjunction with simple biochemical tests. J Clin Microbiol (2000) 38: 4586-4592.| Togo Y, Kubo T, Taoka R, Hiyama Y, Uehara T, Hashimoto J, Kurimura Y, Takahashi S, Tsukamoto T, Miyazaki J, Nishiyama H, Kira S, Kiyota H, Yazawa S, Niwa N, Hongo H, Oya M, Kato T, Yasuda M, Deguchi T, Ishikawa K, Hoshinaga K, Matsumoto M, Shigemura K, Tanaka K, Arakawa S, Fujisawa M, Wada K, Uehara S, Watanabe T, Kumon H, Kobayashi K, Matsubara A, Matsumoto M, Sho T, Hamasuna R, Matsumoto T, Hayami H, Nakagawa M and Yamamoto S: Occurrence of infection following prostate biopsy procedures in Japan: Japanese Research Group for Urinary Tract Infection (JRGU) - a multi-center retrospective study. J Infect Chemother (2014) 20: 232-237.| |
| JaLCDOI | 10.18926/AMO/62774 |
|---|---|
| FullText URL | 75_5_611.pdf |
| Author | Zhou, Yu| Furutani, Michiyo| Athurupana, Rukmali| Nakatsuka, Mikiya| |
| Abstract | Family members are critical mediators of the experiences of transgender people. We studied whether transgen-der subjects had disclosed their identity to their families and their families’ reactions after the disclosure. We also evaluated the subjects’ mental state and its association with disclosure status. Transgender people were recruited for this anonymous questionnaire survey in the Okayama University Hospital gender clinic. Subjects disclosed their identity to family members at the following rates: 68.7% to the father, 89.1% to the mother, 59.1% to a brother, 77.8% to a sister, and 47.6% to grandparents. Fathers had the lowest rate (26.7%) of posi-tive reactions, while over 50% of fathers showed an ambiguous response. Approximately 20% of parents showed a negative response. The majority of parents agreed to hormonal treatment and sex-reassignment sur-gery and that the transgender child should live with the gender they wanted to express. However, the rate of subjects with mood and anxiety disorders according to the Kessler 6 scale was significantly higher in those who experienced negative or ambiguous reactions from family members compared to those who experienced posi-tive reactions. Educational and mental health professionals should support the disclosure process of transgen-der people as well as their family members. |
| Keywords | disclosure family functioning gender nonconformity mental health transgender |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 611 |
| End Page | 623 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703044 |
| Web of Science KeyUT | 000711561600008 |
| NAID | 120007166674 |
| JaLCDOI | 10.18926/AMO/62769 |
|---|---|
| FullText URL | 75_5_567.pdf |
| Author | Takase, Ryosuke| Hagiya, Hideharu| Honda, Hiroyuki| Nakano, Yasuhiro| Ogawa, Hiroko| Obika, Mikako| Ueda, Keigo| Kataoka, Hitomi| Hanayama, Yoshihisa| Otsuka, Fumio| |
| Abstract | Influenza potentially has a high mortality rate when it affects the elderly. We aimed to examine the differences in clinical manifestations in patients with influenza according to their age. This multicenter prospective study was performed in six medical institutions in Okayama and Kagawa prefectures (Japan). Between December 1, 2019 and March 31, 2020, we collected data on adult patients diagnosed with influenza type A, who were strat-ified into younger (20-49 years), middle-aged (50-64 years), and older groups (≥ 65 years). We compared the presence or absence of fever, respiratory symptoms, and extrapulmonary symptoms according to age group. In total, 203 patients (113, younger; 51, middle-aged; and 39, older) were eligible for the analysis. The maxi-mum body temperature and temperature at first physician visit in the older group were significantly lower than those in the younger group. The incidence of respiratory symptoms was not different among the three groups. Chills, muscle pain, and arthralgia as systemic symptoms were noted significantly more frequently in the younger (80.9%) and middle-aged (75.5%) groups than in the older group (51.3%) (p = 0.002). Fever and sys-temic symptoms were less likely to appear in older patients, possibly resulting in the delaying of hospital visits among older adults. |
| Keywords | influenza, elderly fever respiratory symptom |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 567 |
| End Page | 574 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703039 |
| Web of Science KeyUT | 000711561600003 |
| NAID | 120007166669 |
| FullText URL | fulltext20211019-1.pdf |
|---|---|
| Author | Miyajima, Mizuki| Astuti, Fahmi| Fukuda, Takahito| Kodani, Masashi| Iida, Shinsuke| Asai, Shinichiro| Matsuo, Akira| Masuda, Takatsugu| Kindo, Koichi| Hasegawa, Takumi| Kobayashi, Tatsuo C.| Nakano, Takehito| Watanabe, Isao| Kambe, Takashi| |
| Published Date | 2021-10-7 |
| Publication Title | Physical Review B |
| Volume | volume104 |
| Issue | issue14 |
| Publisher | American Physical Society (APS) |
| Start Page | L140402 |
| ISSN | 2469-9950 |
| NCID | AA11187113 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©2021 American Physical Society |
| File Version | publisher |
| DOI | 10.1103/physrevb.104.l140402 |
| Web of Science KeyUT | 000704785600002 |
| Related Url | isVersionOf https://doi.org/10.1103/physrevb.104.l140402 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Noriko| Watanabe, Mayu| Katayama, Akihiro| Noda, Yohei| Eguchi, Jun| Kataoka, Hitomi| Kagawa, Shunsuke| Wada, Jun| |
| Keywords | C-peptide diabetes mellitus immune checkpoint inhibitor insulin secretion |
| Published Date | 2021-09-07 |
| Publication Title | Clinical Case Reports |
| Volume | volume9 |
| Issue | issue9 |
| Publisher | Wiley |
| Start Page | e04574 |
| ISSN | 2050-0904 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 34522382 |
| DOI | 10.1002/ccr3.4574 |
| Web of Science KeyUT | 000700003300112 |
| Related Url | isVersionOf https://doi.org/10.1002/ccr3.4574 |
| FullText URL | fulltext20211018-7a.pdf |
|---|---|
| Author | Watari, Shogo| Araki, Motoo| Matsumoto, Jun| Yoshinaga, Kasumi| Sekito, Takanori| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Kubota, Risa| Nishimura, Shingo| Wada, Koichiro| Kobayashi, Yasuyuki| Takeuchi, Hidemi| Tanabe, Katsuyuki| Kitagawa, Masashi| Morinaga, Hiroshi| Kitamura, Shinji| Sugiyama, Hitoshi| Ariyoshi, Noritaka| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Keywords | Cytochrome P450 tacrolimus renal transplantation CYP2C19 vonoprazan rabeprazole |
| Note | © 2021 The Japanese Society for the Study of Xenobiotics. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.dmpk.2021.100407] .| |
| Published Date | 2021-10-31 |
| Publication Title | Drug Metabolism and Pharmacokinetics |
| Volume | volume40 |
| Publisher | Elsevier Ltd. |
| Start Page | 100407 |
| ISSN | 13474367 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved. |
| File Version | author |
| PubMed ID | 34352707 |
| DOI | 10.1016/j.dmpk.2021.100407 |
| Web of Science KeyUT | 000702719100002 |
| Related Url | isVersionOf https://doi.org/10.1016/j.dmpk.2021.100407 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Ryohtaroh| Takahashi, Daisuke| Watanabe, Masaki| Nakatani, Shunsuke| Takamura, Yuta| Kurosaki, Yuji| Kakuta, Hiroki| Hase, Koji| |
| Keywords | RXR NEt-3IB inflammatory bowel disease colitis Th1 cells |
| Published Date | 2021-08-12 |
| Publication Title | Frontiers In Pharmacology |
| Volume | volume12 |
| Publisher | Frontiers Media SA |
| Start Page | 715752 |
| ISSN | 1663-9812 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Matsumoto, Takahashi, Watanabe, Nakatani, Takamura,Kurosaki, Kakuta and Hase. |
| File Version | publisher |
| PubMed ID | 34475823 |
| DOI | 10.3389/fphar.2021.715752 |
| Web of Science KeyUT | 000693889000001 |
| Related Url | isVersionOf https://doi.org/10.3389/fphar.2021.715752 |
| JaLCDOI | 10.18926/AMO/62409 |
|---|---|
| FullText URL | 75_4_539.pdf |
| Author | Yamamoto, Yukichika| Otsuka, Yuki| Katsuyama, Takayuki| Nishimura, Yoshito| Oka, Kosuke| Hasegawa, Kou| Hagiya, Hideharu| Otsuka, Fumio| |
| Abstract | Primary Sjögren’s syndrome (SS) is an autoimmune disease that usually affects the exocrine glands in mid-dle-aged women. Fifteen percent of SS patients experience severe systemic extraglandular complications, and pleuritis is one of the rare complications of SS. We report the case of an elderly Japanese man who initially pre-sented with a prolonged fever and chest pain and was finally diagnosed with primary SS-associated pleuritis. Of the nine reported cases of primary SS that initially presented with pleuritis, up to six cases were elderly males. This case highlights the complication of pleuritis among elderly males with primary SS. |
| Keywords | Sjögren’s syndrome pleuritis elderly male |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-08 |
| Volume | volume75 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 539 |
| End Page | 542 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34511624 |
| Web of Science KeyUT | 000696755800003 |
| NAID | 120007146035 |
| JaLCDOI | 10.18926/AMO/62407 |
|---|---|
| FullText URL | 75_4_529.pdf |
| Author | Inada, Ryo| Watanabe, Ayako| Toshima, Toshiaki| Katsura, Yuki| Sato, Takuji| Sui, Kenta| Oishi, Kazuyuki| Okabayashi, Takehiro| Ozaki, Kazuhide| Shibuya, Yuichi| Matsumoto, Manabu| Iwata, Jun| |
| Abstract | A 67-year-old woman underwent polypectomy for a tumor at the descending colon. Pathologically, the tumor was diagnosed as adenocarcinoma with an invasion of 2000 μm. Computed tomography showed a swollen paracolic lymph node and a mass lesion in the presacral space. Magnetic resonance imaging revealed a multio-cular cystic lesion. On diagnosis of descending colon cancer and tailgut cyst, she underwent synchronous lapa-roscopic resection. Histopathologically, the colon cancer was diagnosed as pT1bN1M0, pStage IIIa. The pre-sacral cystic lesion was diagnosed as a nonmalignant tailgut cyst with negative surgical margin. The patient is currently doing well without recurrence at 28 months. |
| Keywords | anterior approach laparoscopic resection tailgut cyst |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-08 |
| Volume | volume75 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 529 |
| End Page | 532 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34511622 |
| Web of Science KeyUT | 000696755800001 |
| NAID | 120007146033 |
| JaLCDOI | 10.18926/AMO/62403 |
|---|---|
| FullText URL | 75_4_505.pdf |
| Author | Okamura, Tomoka| Washio, Yosuke| Watanabe, Hirokazu| Nakanishi, Hidehiko| Uchiyama, Atsushi| Tsukahara, Hirokazu| Kusuda, Satoshi| |
| Abstract | Late-onset circulatory collapse (LCC) in preterm infants is presumably caused by relative adrenal insufficiency. Because eosinophilia is known to be associated with adrenal insufficiency, we attempted to clarify the relation-ship between eosinophilia and LCC in preterm infants. We divided the cases of the infants (born at < 28 weeks’ gestation) admitted to our neonatal intensive care unit in 2008-2010 into 2 groups: those diagnosed with LCC that received glucocorticoids (LCC group), and those who did not receive glucocorticoids (control group). We compared eosinophil counts between the 2 groups and between before and after glucocorticoid treatment in the LCC group. A total of 28 infants were examined: LCC group (n = 12); control group (n = 16). The peak eosin-ophil counts of the LCC group were significantly higher than those of the control group (median: 1.392 × 109/L vs. 1.033 × 109/L, respectively; p = 0.02). Additionally, in the LCC group, the eosinophil counts declined significantly after glucocorticoid treatment (0.877 × 109/L vs. 0.271 × 109/L, p = 0.003). Eosinophil counts in the LCC group were significantly higher than in the control group and decreased rapidly after gluco-corticoid treatment. These results indicate that eosinophilia may be a factor associated with LCC caused by adrenal insufficiency. |
| Keywords | late-onset circulatory collapse preterm infant eosinophilia steroid adrenal insufficiency |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-08 |
| Volume | volume75 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 505 |
| End Page | 509 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34511618 |
| Web of Science KeyUT | 000709282300004 |
| NAID | 120007146046 |
| JaLCDOI | 10.18926/AMO/62398 |
|---|---|
| FullText URL | 75_4_461.pdf |
| Author | Murakami, Hiroyuki| Yoshioka, Takanori| Moriyama, Takashi| Ishikawa, Tatsunori| Makita, Masanori| Sunami, Kazutaka| |
| Abstract | Bendamustine plus rituximab (B-R) is an effective therapy for relapsed or refractory (r/r) low-grade B-cell lymphoma (LGBCL) and mantle cell lymphoma (MCL); however, clinical data from Japanese patients treated with B-R therapy are limited. We retrospectively evaluated the efficacy and safety of B-R therapy in 42 patients who received B-R therapy at our hospital for r/r LGBCL and MCL. All patients received intravenous (IV) ritux-imab 375 mg/m2 on day 1 and IV bendamustine 90 mg/m2 on days 2 and 3 every 28 days for up to 6 cycles. The common histologic subtypes were follicular lymphoma (n = 29, 70%), marginal zone lymphoma (n = 6, 14%), and MCL (n = 5, 12%). The overall response rate was 93%, with 62% complete response and complete response unconfirmed. The median progression-free survival (PFS) was 38 months (95% confidence interval [CI], 24.6 to not reached [NR]), and the median overall survival (OS) was 80 months (95% CI, 60.7 to NR). Patients receiving a cumulative dose of bendamustine ≥ 720 mg/m2 showed a significantly longer PFS and OS. Grade 3/4 adverse events (≥ 10%) included neutropenia (55%), lymphopenia (69%), and nausea (24%). B-R therapy was effective and well tolerated, and the cumulative dose of bendamustine was associated with a favorable outcome. |
| Keywords | bendamustine low grade B-cell lymphoma mantle cell lymphoma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-08 |
| Volume | volume75 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 461 |
| End Page | 469 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34511613 |
| Web of Science KeyUT | 000697944600008 |
| NAID | 120007146041 |
| JaLCDOI | 10.18926/AMO/62379 |
|---|---|
| FullText URL | 75_4_415.pdf |
| Author | Sun, Jingkai| Lin, Wenfeng| Wang, Qixu| Sakai, Akiko| Xue, Ruizhi| Watanabe, Masami| Liu, Chunxiao| Sadahira, Takuya| Nasu, Yasutomo| Xu, Abai| Huang, Peng| |
| Abstract | Human RAD17, as an agonist of checkpoint signaling, plays an essential role in mediating DNA damage. This hospital-based case-control study aimed to explore the association between RAD17 rs1045051, a missense sin-gle nucleotide polymorphism (SNP), and prostate cancer risk. Subjects were 358 prostate cancer patients and 314 cancer-free urology patients undergoing treatment at the Zhujiang Hospital of Southern Medical University in China. RAD17 gene polymorphism rs1045051 was evaluated by the SNaPshot method. Compared with the RAD17 gene polymorphism rs1045051 AA genotype, there was a higher risk of prostate cancer for the CC gen-otype (adjusted odds ratio [AOR] = 1.731, 95% confidence interval [95%CI] = 1.031−2.908, p = 0.038). Compared with the A allele, the C allele was significantly associated with the disease status (AOR = 1.302, 95%CI = 1.037−1.634, p = 0.023). All these findings indicate that in the SNP rs1045051, both the CC genotype and C allele may have a substantial influence on the prostate cancer risk. |
| Keywords | prostate cancer single-nucleotide polymorphisms cell cycle checkpoint rs1045051 RAD17 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-08 |
| Volume | volume75 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 415 |
| End Page | 421 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34511607 |
| Web of Science KeyUT | 000697944600002 |
| NAID | 120007146060 |
