検索結果 940 件
| JaLCDOI | 10.18926/AMO/64358 |
|---|---|
| フルテキストURL | 77_1_29.pdf |
| 著者 | Yamamoto, Shusei| Sato, Ikumi| Fujii, Moe| Kakimoto, Mai| Honma, Koki| Akiyama, Natsumi| Sakai, Miku| Fukuhama, Natsuki| Kumazaki, Shota| Hirohata, Satoshi| Kitamori, Kazuya| Yamori, Yukio| Watanabe, Shogo| |
| 抄録 | The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased. |
| キーワード | SHRSP5/Dmc nonalcoholic steatohepatitis cardiovascular disease glycine-conjugated bile acids unconjugated bile acids |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 29 |
| 終了ページ | 36 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849143 |
| Web of Science KeyUT | 000953019200001 |
| JaLCDOI | 10.18926/AMO/64356 |
|---|---|
| フルテキストURL | 77_1_11.pdf |
| 著者 | Watanabe, Satoko| Saiga, Miho| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Kimata, Yoshihiro| |
| 抄録 | The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction. |
| キーワード | breast reconstruction mastectomy brassiere professional bra fitter |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 11 |
| 終了ページ | 19 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849141 |
| Web of Science KeyUT | 000953663800002 |
| JaLCDOI | 10.18926/AMO/64355 |
|---|---|
| フルテキストURL | 77_1_1.pdf |
| 著者 | Nahar, Lutfun| Hagiya, Hideharu| Nada, Takahiro| Iio, Koji| Gotoh, Kazuyoshi| Matsushita, Osamu| Otsuka, Fumio| |
| 抄録 | Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus. We here investigated the frequency and genotypic profiles of iMLSB resistance in clindamycin (CLDM)-susceptible S. aureus isolated in Okayama University Hospital from June 2020 to June 2021. We phenotypically screened the iMLSB resistance via D-zone test and performed PCR testing for the erythromycin ribosomal methylase (erm) genes: ermA and ermC. Among 432 CLDM-susceptible S. aureus isolates, 138 (31.9%) exhibited an iMLSB-resistance phenotype, with methicillinresistant S. aureus isolates (MRSA; 61 isolates: 58.6%) exhibiting higher positivity than methicillin-sensitive S. aureus isolates (MSSA; 77 isolates: 23.5%) (p<0.001). Male patients had a higher frequency of iMLSB resistance than females (OR [95%CI]: 1.8 [1.2-2.8]; p=0.007). Genotypically, ermA predominated in both MSSA (70.1%) and MRSA (86.9%) compared to ermC (14.3% in MSSA and 11.5% in MRSA). A single strain of MRSA possessed both ermA and ermC, while 12 (15.6%) MSSA isolates were negative for both ermA and ermC, suggesting the presence of other genetic mechanisms. Collectively, these results show that approximately 33% of CLDM-susceptible S. aureus isolates at our university hospital exhibited iMLSB resistance, predominantly caused by ermA in both MSSA and MRSA. |
| キーワード | antimicrobial resistance clindamycin erm D-zone test inducible MLSB |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 9 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849140 |
| Web of Science KeyUT | 000953663800001 |
| JaLCDOI | 10.18926/64333 |
|---|---|
| タイトル（別表記） | Investigating the Bow-Pulling Model in Reverse Culture Shock |
| フルテキストURL | scs_022_015.pdf |
| 著者 | 田中 共子| 渡邊 真弓| |
| 抄録 | 逆カルチャーショックの存在は知られるが、その機序の解明は十分とは言い難い。滞在先によく馴染むほど再適応は困難になるとみる「弓引きモデル」が成り立つかどうかをRQ1、文化受容と帰国後のその変化をRQ2、逆カルチャーショックの心理的機序をRQ3として、日本人元留学生12名に半構造化面接を行った。渡航先は北米6名、欧州3名、オセアニア1名、アジア2名であった。語りから社会文化的な認知や行動の変容と維持を抽出し、KJ法を用いて分析した。帰国後切り替えられた文化行動には、表出性（双方向的授業、主張性、明言、相互性）、社会的圧力（自由さ、過度な気遣いなし、おおらかさ）、親近性（身体接触を伴う挨拶、フレンドリーさ、パーティー）のカテゴリが見いだされた。二文化性への態度として、習慣取り入れ、受容の態度、母文化拒否感、転換への消極性、スイッチングのカテゴリが認められた。弓引きモデルの該当例は8名見られた。滞在先で文化受容が進み、帰国後は二文化を客観視する2名は再適応の困難が小さく、俯瞰モデルと名付けられた。文化受容が限定的で母文化が比較的維持され、再適応の速やかな2名は維持モデルと名付けられた。滞在先での文化受容は逆カルチャーショックを潜在的に準備するが、母文化観が相対的でなく拒否的な場合に、再適応の難度が高まる。この機序は、文化受容の可逆性や準拠文化の択一性、文化的スイッチングの機能に関わる問いに繋がる。 |
| キーワード | 逆カルチャーショック 弓引きモデル 社会文化的適応 日本人留学生 リエントリー |
| 出版物タイトル | 文化共生学研究 |
| 発行日 | 2022-12-23 |
| 巻 | 22巻 |
| 開始ページ | 15 |
| 終了ページ | 26 |
| ISSN | 1880-9162 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2022 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Morimoto, Daisaku| Washio, Yosuke| Tamai, Kei| Sato, Takeshi| Okamura, Tomoka| Watanabe, Hirokazu| Fukushima, Yu| Yoshimoto, Junko| Kageyama, Misao| Baba, Kenji| Tsukahara, Hirokazu| |
| キーワード | extremely preterm infants histidine-rich glycoprotein high mobility group box 1 bronchopulmonary dysplasia longitudinal measurement mixed-effects model |
| 発行日 | 2023-01-14 |
| 出版物タイトル | Biomedicines |
| 巻 | 11巻 |
| 号 | 1号 |
| 出版者 | MDPI |
| 開始ページ | 212 |
| ISSN | 2227-9059 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36672720 |
| DOI | 10.3390/biomedicines11010212 |
| Web of Science KeyUT | 000914194300001 |
| 関連URL | isVersionOf https://doi.org/10.3390/biomedicines11010212 |
| フルテキストURL | fulltext20230120-1.pdf |
|---|---|
| 著者 | Tumewu, Stephany Angelia| Watanabe, Yuta| Matsui, Hidenori| Yamamoto, Mikihiro| Noutoshi, Yoshiteru| Toyoda, Kazuhiro| Ichinose, Yuki| |
| キーワード | aerotaxis aeroreceptor MCP Pseudomonas syringae virulence |
| 発行日 | 2022 |
| 出版物タイトル | Microbes and Environments |
| 巻 | 37巻 |
| 号 | 1号 |
| 出版者 | Japanese Society of Microbial Ecology |
| 開始ページ | ME21076 |
| ISSN | 1342-6311 |
| NCID | AA11173196 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles. |
| 論文のバージョン | publisher |
| PubMed ID | 35264479 |
| DOI | 10.1264/jsme2.me21076 |
| Web of Science KeyUT | 000905233400010 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ojima, Hinako| Kuraoka, Sakiko| Okanoue, Shyoutarou| Okada, Hiroyuki| Gotoh, Kazuyoshi| Matsushita, Osamu| Watanabe, Akari| Yokota, Kenji| |
| キーワード | Helicobacter pylori nitrate-reducing bacteria IL-8 TNF-alpha cell cycle |
| 発行日 | 2022-12-16 |
| 出版物タイトル | Microorganisms |
| 巻 | 10巻 |
| 号 | 12号 |
| 出版者 | MDPI |
| 開始ページ | 2495 |
| ISSN | 2076-2607 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36557748 |
| DOI | 10.3390/microorganisms10122495 |
| Web of Science KeyUT | 000903731600001 |
| 関連URL | isVersionOf https://doi.org/10.3390/microorganisms10122495 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hayashi, Keigo| Sada, Ken-Ei| Asano, Yosuke| Katayama, Yu| Ohashi, Keiji| Morishita, Michiko| Miyawaki, Yoshia| Watanabe, Haruki| Katsuyama, Takayuki| Narazaki, Mariko| Matsumoto, Yoshinori| Yajima, Nobuyuki| Yoshimi, Ryusuke| Shimojima, Yasuhiro| Ohno, Shigeru| Kajiyama, Hiroshi| Ichinose, Kunihiro| Sato, Shuzo| Fujiwara, Michio| Wada, Jun| |
| 発行日 | 2022-06-29 |
| 出版物タイトル | Plos One |
| 巻 | 17巻 |
| 号 | 6号 |
| 出版者 | Public Library Science |
| 開始ページ | e0270569 |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Hayashi et al. |
| 論文のバージョン | publisher |
| PubMed ID | 35767524 |
| DOI | 10.1371/journal.pone.0270569 |
| Web of Science KeyUT | 000892027900189 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0270569 |
| フルテキストURL | fulltext20221223-2.pdf |
|---|---|
| 著者 | Maekawa, Kenji| Ikeuchi, Tomoko| Shinkai, Shoji| Hirano, Hirohiko| Ryu, Masahiro| Tamaki, Katsushi| Yatani, Hirofumi| Kuboki, Takuo| Kimura‐Ono, Aya| Kikutani, Takeshi| Suganuma, Takashi| Ayukawa, Yasunori| Gonda, Tomoya| Ogawa, Toru| Fujisawa, Masanori| Ishigaki, Shoichi| Watanabe, Yutaka| Kitamura, Akihiko| Taniguchi, Yu| Fujiwara, Yoshinori| Edahiro, Ayako| Ohara, Yuki| Furuya, Junichi| Nakajima, Junko| Umeki, Kento| Igarashi, Kentaro| Horibe, Yasuhiro| Kugimiya, Yoshihiro| Kawai, Yasuhiko| Matsumura, Hideo| Ichikawa, Tetsuo| Ohkawa, Shuji| Baba, Kazuyoshi| Kusatsu ISLE Study Working Group Collaborators| |
| キーワード | community-dwelling older adults functional teeth loss of independence oral health present teeth |
| 発行日 | 2022-11-21 |
| 出版物タイトル | Geriatrics |
| 巻 | 22巻 |
| 号 | 12号 |
| 出版者 | Wiley |
| 開始ページ | 1032 |
| 終了ページ | 1039 |
| ISSN | 1444-1586 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36408675 |
| DOI | 10.1111/ggi.14508 |
| Web of Science KeyUT | 000888381800001 |
| JaLCDOI | 10.18926/AMO/64122 |
|---|---|
| フルテキストURL | 76_6_715.pdf |
| 著者 | Mohammed Zahedul Islam Nizami| Gorduysus, Melahat| Shinoda-Ito, Yuki| Yamamoto, Tadashi| Nishina, Yuta| Takashiba, Shogo| Arias, Zulema| |
| 抄録 | The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall. |
| キーワード | bioactive sealer graphene oxide mineral deposition antimicrobial activity radiopacity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 715 |
| 終了ページ | 721 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549774 |
| Web of Science KeyUT | 000905195100012 |
| JaLCDOI | 10.18926/AMO/64121 |
|---|---|
| フルテキストURL | 76_6_705.pdf |
| 著者 | Higashikawa, Toshihiro| Ito, Tomohiko| Mizuno, Takurou| Ishigami, Keiichiro| Kuroki, Kengo| Maekawa, Naoto| Usuda, Daisuke| Izumida, Toshihide| Yamada, Shinya| Sangen, Ryusho| Hamada, Kazu| Kiyosawa, Jun| Saito, Atsushi| Iguchi, Masaharu| Kasamaki, Yuji| Nakahashi, Takeshi| Fukuda, Akihiro| Saito, Hitoshi| Kanda, Tsugiyasu| Okuro, Masashi| |
| 抄録 | The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function. |
| キーワード | tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 705 |
| 終了ページ | 713 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549773 |
| Web of Science KeyUT | 000905195100011 |
| JaLCDOI | 10.18926/AMO/64120 |
|---|---|
| フルテキストURL | 76_6_695.pdf |
| 著者 | Onishi, Hideki| Nouso, Kazuhiro| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Takeuchi, Yasuto| Shiraha, Hidenori| Okada, Hiroyuki| |
| 抄録 | This study sought to identify factors that are predictive of a therapeutic response to hepatic arterial infusion chemotherapy (HAIC) by focusing on the number of prior transcatheter arterial chemoembolization (TACE) sessions. To determine the parameters predicting a good response to HAIC, we retrospectively analyzed 170 patients with hepatocellular carcinoma (HCC) who received HAIC regimens comprising low-dose cisplatin combined with 5-fluorouracil (LFP) or cisplatin (CDDP) for the first time. In both the LFP and CDDP regimens, the response rates were significantly lower in patients with three or more prior TACE sessions than in those with two or fewer prior TACE sessions (LFP 57% versus 28%; p=0.01, CDDP 27% versus 6%; p=0.01). Multivariable logistic regression analysis revealed that the number of prior TACE sessions (≥ 3) was significantly associated with non-responder status (odds ratio 4.17, 95% Confidence Interval (CI) 1.76-9.86) in addition to the HAIC regimen. Multivariable analysis using the Cox proportional hazards model revealed that a larger number of prior TACE sessions (≥ 3) was a significant risk factor for survival (hazard ratio 1.60, 95% CI 1.12-2.29) in addition to Child-Pugh class, serum alpha-fetoprotein concentration, and maximum diameter of HCC. HCC patients who receive fewer prior TACE sessions (≤ 2) were found to be better responders to HAIC. |
| キーワード | hepatic arterial infusion chemotherapy hepatocellular carcinoma refractory transcatheter arterial chemoembolization |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 695 |
| 終了ページ | 703 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549772 |
| Web of Science KeyUT | 000905195100010 |
| JaLCDOI | 10.18926/AMO/64118 |
|---|---|
| フルテキストURL | 76_6_679.pdf |
| 著者 | Asagi, Akinori| Sakaguchi, Chihiro| Nadano, Seijin| Nishina, Tomohiro| Hamamoto, Yasushi| Kataoka, Masaaki| Yamashita, Natsumi| Tanimizu, Masahito| Hyodo, Ichinosuke| |
| 抄録 | Chemotherapy is insufficient to treat macroscopic vascular invasion (MVI) of hepatocellular carcinoma (HCC). We retrospectively investigated the treatment outcomes of patients who underwent three-dimensional conformal radiotherapy (3D-CRT) for HCC MVI and analyzed prognostic factors by multivariate analysis using a Cox proportional hazard model. Sixty-five patients were studied. MVI sites were the portal vein (n=48 patients), portal and hepatic veins (n=8), and hepatic vein (n=9). The median irradiation dose was 50 Gy. The median survival time (MST) was 7.5 months. Performance status 2 or 3, modified albumin-bilirubin grade 2b or 3, and massive/diffuse type were poor prognostic factors. Nineteen patients (29%) with a treatment effect of 3 or 4 (≥ 50% of tumor necrosis or regression) at the irradiation sites according to the Response Evaluation Criteria in Cancer of the Liver showed longer survival than those with an effect of 1 or 2 (MST 18.7 vs. 5.9 months, p<0.001). No treatment-related death occurred. The hepatic function reserve was preserved in more than 70% of patients. 3D-CRT controlled HCC MVI safely and was suggested to be a good treatment option. |
| キーワード | hepatocellular carcinoma macroscopic vascular invasion portal vein tumor thrombosis hepatic vein tumor thrombosis three-dimensional conformal radiotherapy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 679 |
| 終了ページ | 688 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549770 |
| Web of Science KeyUT | 000905195100008 |
| JaLCDOI | 10.18926/AMO/64116 |
|---|---|
| フルテキストURL | 76_6_661.pdf |
| 著者 | Abe, Yuko| Taira, Naruto| Kashiwabara, Kosuke| Tsurutani, Junji| Kitada, Masahiro| Takahashi, Masato| Kato, Hiroaki| Kikawa, Yuichiro| Sakata, Eiko| Naito, Yoichi| Hasegawa, Yoshie| Saito, Tsuyoshi| Iwasa, Tsutomu| Takashima, Tsutomu| Aihara, Tomohiko| Mukai, Hirofumi| Hara, Fumikata| Shien, Tadahiko| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| 抄録 | Chemotherapy-induced peripheral neuropathy (CIPN) is an important clinical challenge that threatens patients’ quality of life. This sub-study of the ABROAD trial investigated the influence of single nucleotide polymorphisms (SNPs) on CIPN, using genotype data from a randomized study to determine the optimal dose of a 3-week-cycle regimen of nab-paclitaxel (q3w nab-PTX) in patients with metastatic breast cancer (MBC). Patients with HER2-negative MBC were randomly assigned to three doses of q3w nab-PTX (SD: 260 mg/m2 vs. MD: 220 mg/m2 vs. LD: 180 mg/m2). Five SNPs (EPHA4-rs17348202, EPHA5-rs7349683, EPHA6-rs301927, LIMK2-rs5749248, and XKR4-rs4737264) were analyzed based on the results of a previous genome-wide association study. Per-allele SNP associations were assessed by a Cox regression to model the cumulative dose of nab-PTX up to the onset of severe or worsening sensory neuropathy. A total of 141 patients were enrolled in the parent study; 91(65%) were included in this sub-study. Worsening of CIPN was significantly greater in the cases with XKR4 AC compared to those with a homozygote AA (HR 1.86, 95%CI: 1.00001−3.46, p=0.049). There was no significant correlation of CIPN with any other SNP. A multivariate analysis showed that the cumulative dose of nab-PTX was most strongly correlated with CIPN (p<0.01). |
| キーワード | metastatic breast cancer taxane-induced peripheral neuropathy chemotherapy-induced peripheral neuropathy nab-paclitaxel single nucleotide polymorphism |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 661 |
| 終了ページ | 671 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549768 |
| Web of Science KeyUT | 000905195100006 |
| JaLCDOI | 10.18926/AMO/64112 |
|---|---|
| フルテキストURL | 76_6_625.pdf |
| 著者 | Liu Zhisheng| Li, Qingmei| Wang, Ye| Ge, Yunjie| |
| 抄録 | This investigation aimed to uncover the impact of a long noncoding RNA, SET-binding factor 2 antisense RNA1 (SBF2-AS1) on the malignant progression of gastric cancer (GC) and to further explore its underlying mechanism. SBF2-AS1 expression was quantified by qRT-PCR in GC cell lines and GC tissues. In vitro loss-of-function studies of SBF2-AS1, accompanied by flow cytometry, CCK-8, and cell invasion tests, were applied to elucidate the impact of SBF2-AS1 on the tumor progression of GC cells. Finally, Western blotting and a luciferase assay were used to detect WNT/LRP5 signaling pathway activation. SBF2-AS1 was aberrantly expressed in GC cell lines (p<0.05) and GC tissues (p<0.05). Cell invasive and proliferative capabilities were inhibited via SBF2-AS1 knockdown, resulting in apoptosis of NCI-N87 and MKN74 cells. Additionally, online database analysis uncovered a positive correlation between SBF2-AS1 and the Wnt/LRP5 signaling pathway (p<0.05). SBF2-AS1 knockdown blocked the Wnt/LRP5 signaling pathway, whereas the effects of SBF2-AS1 knockdown on the malignant genotype of MKN74 as well as NCI-N87 cells were partially restored by triggering the Wnt/ LRP5 signaling pathway. High expression of SBF2-AS1 was found in GC, the malignant progression of which was repressed via SBF2-AS1 knockdown by inhibiting the Wnt/LRP5 signaling pathway. |
| キーワード | gastric cancer (GC) SET-binding factor 2 antisense RNA1 (SBF2-AS1) invasion proliferation signaling |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 625 |
| 終了ページ | 633 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549764 |
| Web of Science KeyUT | 000905195100002 |
| フルテキストURL | K0006685_abstract_review.pdf K0006685_summary.pdf |
|---|---|
| 著者 | 黒岡 直子| |
| 発行日 | 2022-09-22 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6685号 |
| 学位授与年月日 | 2022-09-22 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| JaLCDOI | 10.18926/AMO/64042 |
|---|---|
| フルテキストURL | 76_5_597.pdf |
| 著者 | Watanabe, Shiho| Watanabe, Toshiyuki| Yamada, Kiyoshi| Namba, Yuzaburo| Kimata, Yoshihiro| |
| 抄録 | Gender affirming surgery (GAS) has important impacts for people with gender incongruence (GI), both physically and socially. As the societal acceptance of gender diversity spreads, the number of individuals with GI who wish to be identified as the gender of their choice is increasing. Indeed, many elderly people who have lived a long time with GI now wish to undergo GAS, but face greater surgical risks due to greater burdens of underlying medical conditions. Generally, vaginoplasty is performed for transwomen; however, this surgery is time-consuming and involves heavy bleeding, and thus, should be avoided in elderly people. A less invasive technique is needed. In this article, we describe a new, less invasive genital feminizing surgical technique for transwomen with reports from two clinical cases. We present this novel technique as a safe, aesthetic, and cost-effective option for gender-affirming surgery for transwomen. |
| キーワード | gender-affirming surgery, vaginoplasty gender incongruence transwomen |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 597 |
| 終了ページ | 603 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352808 |
| Web of Science KeyUT | 000884907100014 |
| JaLCDOI | 10.18926/AMO/64041 |
|---|---|
| フルテキストURL | 76_5_593.pdf |
| 著者 | Noumi, Taku| Watanabe, Hiromi| Ninomiya, Kiichiro| Ohashi, Kadoaki| Ichihara, Eiki| Kubo, Toshio| Makimoto, Go| Kato, Yuka| Fujii, Masanori| Tabata, Masahiro| Maeda, Yoshinobu| Hotta, Katsuyuki| Kiura, Katsuyuki| |
| 抄録 | We encountered a woman with re-enlarged axillary lymph nodes during a computed tomography (CT) scan for surveillance of lung adenocarcinoma with axillary lymph node metastasis at the initial diagnosis that had shrunk with standard chemotherapy. We first suspected cancer recurrence and considered a change in the chemotherapeutic regimen. However, after careful history taking regarding the timing of her Coronavirus Disease 2019 (COVID-19) vaccination, and subsequent careful, close follow-up, radiological shrinkage suggested a strictly benign cause. Especially in lung cancer with a medical history of axillary lymph node involvement, cliniciansshould be aware that vaccine-associated lymphadenopathy can mimic cancer recurrence and sometimesprompt serious misjudgment regarding a current treatment course and strategy. |
| キーワード | lung cancer COVID-19 vaccination axillary lymphadenopathy case report |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 593 |
| 終了ページ | 596 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352807 |
| Web of Science KeyUT | 000884907100013 |
| JaLCDOI | 10.18926/AMO/64040 |
|---|---|
| フルテキストURL | 76_5_585.pdf |
| 著者 | Choshi, Haruki| Watanabe, Mototsugu| Furukawa, Shinichi| Ujike, Hiroyuki| Kataoka, Kazuhiko| |
| 抄録 | Pulmonary metastatic resection is a standard therapy for renal cell carcinoma (RCC). Although patients with pulmonary metastases who do not undergo any treatment have poor prognoses, it has been reported that resection for pulmonary metastases yields good clinical outcomes. We investigated the prognoses of the 10 Japanese patients (eight males, two females) who underwent a surgical resection of pulmonary metastasectomy from RCC at our institution between April 1, 2012 and March 31, 2020 and analyzed the prognostic factors. We determined the prognoses and calculated the 5-year overall survival (OS) and disease-free survival (DFS) rates. To identify prognostic factors, we compared the median DFS duration for each factor. Elderly patients (median age, 75.5 years) were more predominant compared to previous studies, and all 10 patients underwent a complete resection. The 5-year DFS rate was 30.5% (95%CI: 0.045-0.63) and the 5-year OS rate was 80% (95%CI: 0.20-0.97). The following factors were associated with better prognosis: female, disease-free interval≥36 months, and metastases size<12 mm. These results indicate that complete resection for pulmonary metastases from RCC resulted in good clinical outcomes, particularly for patients with better prognostic factors. |
| キーワード | renal cell carcinoma pulmonary metastasis complete resection |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 585 |
| 終了ページ | 591 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352806 |
| Web of Science KeyUT | 000884907100012 |
| フルテキストURL | mjou_065_145_173.pdf |
|---|---|
| 著者 | Kametaka, Yoshinori| Watanabe, Kohtaro| Nagai, Atsushi| Takemura, Kazuo| Yamagishi, Hiroyuki| |
| 抄録 | We consider the boundary value problem for fourth order linear ordinary differential equation in a half line (0,∞), which represents bending of a beam on an elastic foundation under a tension. A tension is relatively stronger than a spring constant of elastic foundation. We here treat four self-adjoint boundary conditions, clamped, Dirichlet, Neumann and free edges, at x = 0. We show the positivity and the hierarchical structure of four Green functions. |
| キーワード | Green function boundary value problem positivity hierarchical structure |
| 発行日 | 2023-01 |
| 出版物タイトル | Mathematical Journal of Okayama University |
| 巻 | 65巻 |
| 号 | 1号 |
| 出版者 | Department of Mathematics, Faculty of Science, Okayama University |
| 開始ページ | 145 |
| 終了ページ | 173 |
| ISSN | 0030-1566 |
| NCID | AA00723502 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright ©2023 by the Editorial Board of Mathematical Journal of Okayama University |