検索結果 3143 件
| フルテキストURL | BBRC_480_4_564.pdf BBRC_480_4_564_highlights.pdf BBRC_480_4_564_fig.pdf BBRC_480_4_564_suppl_fig.pdf |
|---|---|
| 著者 | Ujihara, Yoshihiro| Mohria, Satoshi| Katanosaka, Yuki| |
| キーワード | Heart failure Junctophilin-2 L-type Ca(2+) channel Na(+)/Ca(2+) exchanger 1 Pressure-overloading Transverse-tubule |
| 備考 | 2017年11月公開予定| |
| 発行日 | 2016-11 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 480巻 |
| 号 | 4号 |
| 出版者 | Elsevier |
| 開始ページ | 564 |
| 終了ページ | 569 |
| ISSN | 0006-291X |
| NCID | AA00564395 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 27789286 |
| DOI | 10.1016/j.bbrc.2016.10.090 |
| Web of Science KeyUT | 000389015400011 |
| 関連URL | https://doi.org/10.1016/j.bbrc.2016.10.090 |
| JaLCDOI | 10.18926/AMO/55312 |
|---|---|
| フルテキストURL | 71_4_345.pdf |
| 著者 | Tanaka, Masato| Sugimoto, Yoshihisa| Takigawa, Tomoyuki| Kimata, Yoshihiro| Ozaki, Toshifumi| |
| 抄録 | Osteoradionecrosis (ORN), a well-known complication of radiotherapy in the mandibular bone, is very rare in the cervical spine. The authors report the result of a 3-year follow-up of a 63-year-old female patient with ORN of the cervical spine. The patient had a history of laryngeal carcinoma and was treated with chemotherapy and radiation therapy with a total of 120 Gy. Eight years later, she developed acute, severe neck pain due to cervical spine necrosis. The authors performed vascularized fibular bone graft and posterior pedicle screw fixation to reconstruct her cervical spine. The patient was successfully treated with surgery, and cervical alignment was preserved. She had neither neurological deficits nor severe neck pain at her final follow-up 3 years later. Delaying treatment of ORN may be life threatening, so the early diagnosis of this condition is important for patients who receive radiotherapy. Otolaryngologists and spine surgeons should understand this potential complication to speed diagnosis and treatment as early as possible. |
| キーワード | osteoradionecrosis laryngeal carcinoma cervical spine radiotherapy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-08 |
| 巻 | 71巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 345 |
| 終了ページ | 349 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28824191 |
| JaLCDOI | 10.18926/AMO/55311 |
|---|---|
| フルテキストURL | 71_4_341.pdf |
| 著者 | Yamazaki, Kenji| Wakabayashi, Hiroshi| Suganami, Yu| Sano, Shinichi| Wakunami, Yu| Katayama, Takashi| Deguchi, Kentaro| Nagotani, Shoko| Kishida, Masayuki| |
| 抄録 | We report a case of a woman with typical dermatomyositis (DM) with skin manifestations, severe myalgia and muscle weakness complicated by interstitial lung disease (ILD) and pneumomediastinum. Pneumomediastinum persisted despite treatment with immunosuppressive therapy (steroids and cyclosporine). After the test for anti-melanoma differentiation-associated gene 5 (MDA5) antibody came out positive, we doubled the cyclosporine dose and her condition improved. Despite typical clinical features of DM, in cases complicated by pneumomediastinum or steroid resistance, measurement of anti-MDA5 antibody may be useful for immunosuppressant dose titration. |
| キーワード | dermatomyositis anti-melanoma differentiation-associated gene 5 antibody interstitial lung disease pneumomediastinum |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-08 |
| 巻 | 71巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 341 |
| 終了ページ | 344 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28824190 |
| JaLCDOI | 10.18926/AMO/55307 |
|---|---|
| フルテキストURL | 71_4_309.pdf |
| 著者 | Asakura, Rie| Miyatake, Nobuyuki| Dokai Mochimasu, Kazumi| Kurato, Risa| Kuwana, Susumu| |
| 抄録 | We investigated the link between proteinuria and psychological distress among patients with type 2 diabetes mellitus (T2DM). A total of 130 patients with T2DM aged 69.1±10.3 years were enrolled in this cross-sectional study. Urine and blood parameters, age, height, body weight, and medications were analyzed, and each patient’s psychological distress was measured using the six-item Kessler Psychological Distress Scale (K6). We compared the K6 scores between the patients with and without proteinuria. Forty-two patients (32.3%) had proteinuria (≥±) and the level of HbA1c was 7.5±1.3%. The K6 scores of the patients with proteinuria were significantly higher than those of the patients without proteinuria even after adjusting for age and sex. The clinical impact of proteinuria rather than age, sex and HbA1c was demonstrated by a multiple regression analysis. Proteinuria was closely associated with higher psychological distress. Preventing and improving proteinuria may reduce psychological distress in patients with T2DM. |
| キーワード | proteinuria psychological distress K6 type 2 diabetes mellitus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-08 |
| 巻 | 71巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 309 |
| 終了ページ | 314 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28824186 |
| フルテキストURL | Dent_Material_33_3_e124.pdf |
|---|---|
| 著者 | Yoshihara, Kumiko| Nagaoka, Noriyuki| Maruo, Yukinori| Nishigawa, Goro| Irie, Masao| Yoshida, Yasuhiro| Meerbeekf, Bart Van| |
| キーワード | CAD–CAM bond strength composite sandblast silane coupling agent |
| 発行日 | 2017-03 |
| 出版物タイトル | Dental Materials |
| 巻 | 33巻 |
| 号 | 3号 |
| 出版者 | Elsevier Science |
| 開始ページ | e124 |
| 終了ページ | e135 |
| ISSN | 0109-5641 |
| NCID | AA10443138 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 28057347 |
| DOI | 10.1016/j.dental.2016.12.003 |
| Web of Science KeyUT | 000396409900004 |
| 関連URL | isVerionOf https://doi.org/10.1016/j.dental.2016.12.003 |
| フルテキストURL | K0005288_other.pdf |
|---|---|
| 著者 | Sejima, Hiroe| Mori, Kyoko| Ariumi, Yasuo| Ikeda, Masanori| Kato, Nobuyuki| |
| キーワード | HCV HCV RNA replication system Li23 cells Long-term RNA replication Upregulated host genes Downregulated host genes |
| 備考 | 学位審査副論文| |
| 発行日 | 2012-07 |
| 出版物タイトル | Virus Research |
| 巻 | 167巻 |
| 号 | 1号 |
| 出版者 | Elsevier Science |
| 開始ページ | 74 |
| 終了ページ | 85 |
| ISSN | 0168-1702 |
| NCID | AA10642076 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 22579597 |
| DOI | 10.1016/j.virusres.2012.04.008 |
| Web of Science KeyUT | 000305496700010 |
| 関連URL | https://doi.org/10.1016/j.virusres.2012.04.008 http://ousar.lib.okayama-u.ac.jp/54271 |
| タイトル（別表記） | The development of a scale to measure stress recognition during the treatment of diabetes patients |
|---|---|
| フルテキストURL | 129_93.pdf |
| 著者 | 住吉 和子| 川田 智恵子| 岡本 辰夫| 大橋 睦子| 實金 栄| 高林 範子| 太湯 好子| 金 外淑| 和田 淳| 四方 賢一| 中嶋 和夫| |
| 抄録 | The purpose of this study was to establish a measurement scale for "stress recognition in receiving treatment" in patients with diabetes. A self-completed questionnaire was distributed to 149 type-2 diabetes outpatients in March-May 2015 after authorization from Okayama Prefectural University and the ethics committee of the hospital. The "stress recognition in receiving treatment" scale was designed as a second-order factor model consisting of 14 items and the following four factors : the respondent's sense of (1) the burden of being sick, (2) the burden on interpersonal relationships, (3) the burden of treatment, and (4) the burden of medical expenses. Stress recognition in treatment means recognition of being stressed in the burdens related to the illness, interpersonal relationships, treatment and medical expenses. The suitability of the questionnaire data was then evaluated with a structural equation model. The suitability of the factor model to the data satisfied the statistically acceptable standards as Comparative Fit Index (CFI) ＝0.931, Root Mean Square Error of Approximation (RMSEA) ＝0.096, Tucker-Lewis Index (TLI) ＝0.946. As the construct validity was not examined by the scale created in this study or by existing scale, it was verified by using the degrees of mental healthiness and HbA1c that were proved to be associated with the sense of burden. In addition, the construct validity of the questionnaire was supported by a significant correlation between the Japanese version of the WHO-Five Well-being Index (S-WHO-5-J) and the patients' HbA1c levels. The use of this measure is expected to contribute to the early detection of a decline in a diabetic patient's activities of daily living and to the early confirmation of patients' support status. |
| キーワード | 糖尿病患者 (diabetes patients) 治療 (treatment) ストレス認知 (stress recognition) 尺度開発 (development of a scale) |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2017-08-01 |
| 巻 | 129巻 |
| 号 | 2号 |
| 開始ページ | 93 |
| 終了ページ | 99 |
| ISSN | 0030-1558 |
| 関連URL | https://doi.org/10.4044/joma.129.93 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2017 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.129.93 |
| NAID | 130006039367 |
| フルテキストURL | Acta_Neurochir_159_7_1329.pdf |
|---|---|
| 著者 | Kidani, Naoya| Sugiu, Kenji| Hishikawa, Tomohito| Hiramatsu, Masafumi| Haruma, Jun| Nishihiro, Shingo| Takahashi, Yu| Date, Isao| |
| キーワード | De novo aneurysm Hemodynamic stress Stent-assisted coil embolization Vertebral artery dissecting aneurysm |
| 発行日 | 2017-07 |
| 出版物タイトル | Acta Neurochirurgica |
| 巻 | 159巻 |
| 号 | 7号 |
| 出版者 | Springer |
| 開始ページ | 1329 |
| 終了ページ | 1333 |
| ISSN | 00016268 |
| NCID | AA0050885X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 28493024 |
| DOI | 10.1007/s00701-017-3204-2 |
| Web of Science KeyUT | 000403508400024 |
| 関連URL | https://doi.org/10.1007/s00701-017-3204-2 |
| フルテキストURL | K0005280_fulltext.pdf |
|---|---|
| 著者 | Ishigami, Shuta| Ohtsuki, Shinichi| Tarui, Suguru| Ousaka, Daiki| Eitoku, Takahiro| Kondo, Maiko| Okuyama, Michihiro| Kobayashi, Junko| Baba, Kenji| Arai, Sadahiko| Kawabata, Takuya| Yoshizumi, Ko| Tateishi, Atsushi| Kuroko, Yosuke| Iwasaki, Tatsuo| Sato, Shuhei| Kasahara, Shingo| Sano, Shunji| Oh, Hidemasa| |
| キーワード | cell therapy congenital heart disease hypoplastic left heart syndrome stem cells |
| 備考 | 学位審査副論文| |
| 発行日 | 2015-02 |
| 出版物タイトル | Circulation Research |
| 巻 | 116巻 |
| 号 | 4号 |
| 出版者 | Lippincott Williams & Wilkins |
| 開始ページ | 653 |
| 終了ページ | 664 |
| ISSN | 00097330 |
| NCID | AA00133553 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 25403163 |
| DOI | 10.1161/circresaha.116.304671 |
| Web of Science KeyUT | 000349804900015 |
| 関連URL | https://doi.org/10.1161/CIRCRESAHA.116.304671 http://ousar.lib.okayama-u.ac.jp/54044 http://ousar.lib.okayama-u.ac.jp/54263 |
| フルテキストURL | K0005439_other2.pdf |
|---|---|
| 著者 | Onoda, Satoshi| Kimata, Yoshihiro| Matsumoto, Kumiko| Yamada, Kiyoshi| |
| 備考 | 学位審査副論文| |
| 発行日 | 2016-01 |
| 出版物タイトル | Plastic and Reconstructive Surgery |
| 巻 | 137巻 |
| 号 | 1号 |
| 出版者 | Lippincott Williams & Wilkins |
| 開始ページ | 83e |
| 終了ページ | 91e |
| ISSN | 00321052 |
| NCID | AA00775696 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 26710064 |
| DOI | 10.1097/PRS.0000000000001884 |
| Web of Science KeyUT | 000367333300001 |
| 関連URL | https://doi.org/10.1097/PRS.0000000000001884 |
| フルテキストURL | K0005572_abstract_review.pdf K0005572_summary.pdf K0005572_fulltext.pdf |
|---|---|
| 著者 | 能島 舞| |
| 発行日 | 2017-06-30 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5572号 |
| 学位授与年月日 | 2017-06-30 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| フルテキストURL | K0005463_other1.pdf |
|---|---|
| 著者 | Higuchi, Yuji | Uchitomi, Yosuke| Fujimori, Maiko| Koyama, Toshihiro| Kataoka, Hitomi| Kitamura, Yoshihisa| Sendo, Toshiaki| Inagaki, Masatoshi| |
| キーワード | Empathy Hospital pharmacist Japan Pharmaceutical care |
| 備考 | The final publication is available at Springer| 岡山大学審査学位副論文| |
| 発行日 | 2015-12 |
| 出版物タイトル | International Journal of Clinical Pharmacy |
| 巻 | 37巻 |
| 号 | 6号 |
| 出版者 | Springer |
| 開始ページ | 1258 |
| 終了ページ | 1266 |
| ISSN | 2210-7703 |
| NCID | AA12633112 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 26441314 |
| DOI | 10.1007/s11096-015-0204-2 |
| Web of Science KeyUT | 000363490100042 |
| 関連URL | https://doi.org/10.1007/s11096-015-0204-2 http://ousar.lib.okayama-u.ac.jp/55016 |
| JaLCDOI | 10.18926/AMO/55208 |
|---|---|
| フルテキストURL | 71_3_249.pdf |
| 著者 | Washio, Kana| Muraoka, Michiko| Kanamitsu, Kiichiro| Oda, Megumi| Shimada, Akira| |
| 抄録 | We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH. |
| キーワード | langerhans cell histiocytosis (LCH) hemophagocytic lymphohistiocytosis (HLH) hematopoietic stem cell transplantation (HSCT) reduced-intensity conditioning (RIC) refractory |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 249 |
| 終了ページ | 254 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655945 |
| JaLCDOI | 10.18926/AMO/55207 |
|---|---|
| フルテキストURL | 71_3_241.pdf |
| 著者 | Iwamuro, Masaya| Tanaka, Shouichi| Moritou, Yuki| Inaba, Tomoki| Higashi, Reiji| Kusumoto, Chiaki| Yunoki, Naoko| Ishikawa, Shin| Okamoto, Yuko| Kawai, Yoshinari| Kitada, Ken-ichi| Takenaka, Ryuta| Toyokawa, Tatsuya| Okada, Hiroyuki| |
| 抄録 | Most gastric bezoars can be treated with endoscopic fragmentation combined with or without cola dissolution, whereas laparotomy or laparoscopic surgery is generally inevitable for small intestinal bezoars because they cause small bowel obstruction. Therefore, early diagnosis and management of gastric bezoars are necessary to prevent bezoar-induced ileus. To investigate the incidence of overlooked gastric bezoars during the initial esophagogastroduodenoscopy, we retrospectively reviewed the cases of 27 patients diagnosed with gastrointestinal bezoars. The bezoars were diagnosed using esophagogastroduodenoscopy (n=25), abdominal ultrasonography (n=1), and barium follow-through examination (n=1). Bezoars were overlooked in 9/25 patients (36.0%) during the initial endoscopy examination because the bezoars were covered with debris in the stomach. Of the 9 patients, 8 had concomitant gastric ulcers, and the other patient had gastric lymphoma. Although a computed tomography (CT) scan was performed before the second-look endoscopy in 8 of the 9 patients, the bezoars were mistaken as food debris on CT findings and were overlooked in these patients. In conclusion, gastric bezoars may not be discovered during the initial esophagogastroduodenoscopy and CT scan. In cases with debris in the stomach, second-look endoscopy is essential to detect bezoars. |
| キーワード | bezoar gastric ulcer foreign bodies phytobezoar |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 241 |
| 終了ページ | 247 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655944 |
| JaLCDOI | 10.18926/AMO/55206 |
|---|---|
| フルテキストURL | 71_3_233.pdf |
| 著者 | Shimoyama, Kyoko| Osako, Tomo| Mitsuhashi, Toshiharu| Akiyama, Futoshi| Iwase, Takuji| |
| 抄録 | Ductal carcinoma in situ (DCIS) of the breast has no potential to metastasize, but over 20% of cases preoperatively diagnosed as DCIS are upstaged on final pathology. The rates of upstaging and the predictors for invasion on final pathology were evaluated. For 240 primary breast cancers, radiological findings on mammography, ultrasonography, and magnetic resonance imaging were investigated along with pathological and clinical information. Univariate and multivariate analyses were performed to identify predictors of potential invasion. Of the 240 breast cancers, 68 (28.3%) showed invasion on final pathology, and 5 (2.5%) had sentinel node metastasis. The multivariate analysis identified five independent predictors: non-mass lesions >2.4 cm on ultrasonography (odds ratio [OR] 2.84, 95% confidence interval [CI] 1.02-7.95, p=0.047), comedo-type histology (OR 6.89, 95% CI 1.89-25.08, p<0.01), solid-type histology (OR 7.97, 95% CI 2.08-30.49, p<0.01), palpable mass (OR 2.63, 95% CI 1.05-6.64, p=0.04), and bloody nipple discharge (OR 4.61, 95% CI 1.20-17.66, p=0.02). These five predictors were associated with invasion on final pathology and may help select candidates for sentinel node biopsy. |
| キーワード | breast cancer DCIS breast needle biopsy imaging examination sentinel node biopsy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 233 |
| 終了ページ | 240 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655943 |
| フルテキストURL | J_Comp_Neurol_525_7_1586.pdf |
|---|---|
| 著者 | Tamura, Kei| Kobayashi, Yasuhisa| Hirooka, Asuka| Takanami, Keiko| Oti, Takumi| Jogahara, Takamichi| Oda, Sen-ichi| Sakamoto, Tatsuya| Sakamoto, Hirotaka| |
| キーワード | RRID AB_2060157 RRID: AB_2571636 RRID: AB_626757 Suncus murinus (suncus) gastrin-releasing peptide male reproductive function sexual dimorphism spinal cord |
| 備考 | This is the peer reviewed version of the following article: Tamura K. Kobayashi Y. Hirooka A. et al. Identification of the sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that controls male reproductive function in the mouse and Asian house musk shrew (Suncus murinus). J Comp Neurol. 2017;525:1601–1613. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.| 2018年5月公開予定| |
| 発行日 | 2017-05-01 |
| 出版物タイトル | Journal of Comparative Neurology |
| 巻 | 525巻 |
| 号 | 7号 |
| 出版者 | Wistar Institute of Anatomy and Biology |
| 開始ページ | 1586 |
| 終了ページ | 1598 |
| ISSN | 0021-9967 |
| NCID | AA00695917 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 27804131 |
| DOI | 10.1002/cne.24138 |
| Web of Science KeyUT | 000397559700004 |
| 関連URL | https://doi.org/10.1002/cne.24138 |
| タイトル（別表記） | Identification of Marker Gene of Pars Tuberalis Morphogenesis in Chicken Embryo. The expression of Cytokine-like 1 and Gap junction protein alpha 5 in the pars tuberalis |
|---|---|
| フルテキストURL | poalas_033_031_034.pdf |
| 著者 | 相澤 清香| 檜垣 佑理子| 御輿 真穂| 竹内 栄| 高橋 純夫| |
| 抄録 | Adenohypophysis delivered from oral ectoderm consists of pars distalis (PD), pars intermedia and pars tuberalis (PT). The mechanisms of development of PD has been well studied, and the cell differentiation of PD has been well understood. However, the morphogenesis and the differentiation of PT are still unclear, and the gene expression during the PT development remains largely unknown. In this study, we explored the specifically expressing genes in PT during development and analyzed its spatiotemporal expressions pattern. Microarray analysis on laser-captured PT and PD tissues obtained from chicken embryos on embryonic day 10 (E10.0) showed high expressing genes, Cytokine-like 1 (CYTL1) and Gap junction protein alpha 5 (GJA5) in PT. A detail analysis of spatiotemporal expressions pattern during chick embryo development by in situ hybridization revealed that CYTL1 mRNA was first detected in lateral head ectoderm and ventral head ectoderm in E1.5. The CYTL1 expressions moved into Rathke’s pouch at E2.5, then it was localized in PT primordium and continuously expressed in PT primordium until E12.0. On the other hand, GJA5 mRNA was transiently detected in PT primordium from E6 to E14.0, while the expression was not detected in PD during development. These results suggested that these genes may be involved in the regulation mechanism of PT development and could be a useful marker in the PT development. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 31 |
| 終了ページ | 34 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Inhibitory effects of caffeine on allergic rhinitis symptoms in mice |
|---|---|
| フルテキストURL | poalas_033_018_021.pdf |
| 著者 | 辻本 まどか| 佐伯 綾希子| 鈴木 真奈美| 白神 俊幸| 杉本 幸雄| 林 泰資| |
| 抄録 | We examined the effects of caffeine treatment on ovalbumin- and histamine-induced rhinitis mouse models and on corticosterone and catecholamine levels in mouse plasma. Treatment with caffeine decreased sneezing and nasal rubbing in both models, but direct nasal administration had no effect. Plasma levels of corticosterone and catecholamine, which have known anti-allergy effects, were increased by caffeine treatment. The increases in corticosterone and catecholamine may be associated with the suppression of rhinitis symptoms. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 18 |
| 終了ページ | 21 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Dissecting the hierarchy and lineage of mesenchymal stem cells by mouse genetics |
|---|---|
| フルテキストURL | poalas_033_015_017.pdf |
| 著者 | 宝田 剛志| |
| 抄録 | Determination of stem cell hierarchy/lineage is indispensable for a better understanding and augmentation of many aspects of medical sciences, including the mechanisms of tissue development and maintenance of tissue homeostasis, as well as disease development. It also has implications in the field of tissue regeneration for medical treatments and disease modeling for drug discovery using iPS technology. Mesenchymal stem cells are multipotent stem cell that can differentiate into various type of cells including osteoblasts, adipocytes, myocytes and chondrocytes. Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation. Runx2 deficiency in Prx1+-derived cells (Runx2prx1−/− mice) resulted in defective intramembranous ossification. Double-positive cells for Prx1-GFP and stem cell antigen-1 (Sca1) (Prx1+Sca1+ cells) in the calvaria expressed Runx2 at lower levels and were more homogeneous and primitive as compared with Prx1+Sca1− cells. Our results suggest that osteoblast differentiation in vivo may begin at the Prx1+Sca1+ MSC stage with sequential progression to Prx1+Sca1−cells, then Osx+Prx1−Sca1− osteoblast precursors, which eventually form mature α1(I)-collagen+ osteoblasts. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 15 |
| 終了ページ | 17 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/AMO/54982 |
|---|---|
| フルテキストURL | 71_2_135.pdf |
| 著者 | Mori, Akihiro| Watanabe, Masami| Sadahira, Takuya| Kobayashi, Yasuyuki| Ariyoshi, Yuichi| Ueki, Hideo| Wada, Koichiro| Ochiai, Kazuhiko| Li, Shun-Ai| Nasu, Yasutomo| |
| 抄録 | The cluster of differentiation 147 (CD147), also known as EMMPRIN, is a key molecule that promotes cancer progression. We previously developed an adenoviral vector encoding a tumor suppressor REIC/Dkk-3 gene (Ad-REIC) for cancer gene therapy. The therapeutic effects are based on suppressing the growth of cancer cells, but, the underlying molecular mechanism has not been fully clarified. To elucidate this mechanism, we investigated the effects of Ad-REIC on the expression of CD147 in LNCaP prostate cancer cells. Western blotting revealed that the expression of CD147 was significantly suppressed by Ad-REIC. Ad-REIC also suppressed the cell growth of LNCaP cells. Since other researchers have demonstrated that phosphorylated mitogen-activated protein kinases (MAPKs) and c-Myc protein positively regulate the expression of CD147, we investigated the correlation between the CD147 level and the activation of MAPK and c-Myc expression. Unexpectedly, no positive correlation was observed between CD147 and its possible regulators, suggesting that another signaling pathway was involved in the downregulation of CD147. This is the first study to show the downregulation of CD147 by Ad-REIC in prostate cancer cells. At least some of the therapeutic effects of Ad-REIC may be due to the downregulation of the cancer-progression factor, CD147. |
| キーワード | prostate cancer REIC/Dkk-3 CD147 cell growth p38 MAP kinase |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-04 |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 135 |
| 終了ページ | 142 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28420895 |