検索結果 858 件
| 著者 | Miyaji, Takaaki| Kuromori, Takashi| Takeuchi, Yu| Yamaji, Naoki| Yokosho, Kengo| Shimazawa, Atsushi| Sugimoto, Eriko| Omote, Hiroshi| Ma, Jian Feng| Shinozaki, Kazuo| Moriyama, Yoshinori| |
|---|---|
| 発行日 | 2015-01-05 |
| 出版物タイトル | Nature Communications |
| 巻 | 6巻 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/53342 |
|---|---|
| フルテキストURL | 69_2_123.pdf |
| 著者 | Waseda, Koichi| Hagiya, Hideharu| Hanayama, Yoshihisa| Terasaka, Tomohiro| Kimura, Kosuke| Tsuzuki, Takao| Hasegawa, Kou| Nada, Takahiro| Nakamura, Eri| Murakami, Kazutoshi| Kondo, Eisei| Otsuka, Fumio| |
| 抄録 | An 81-year-old Japanese male with primary Sjögren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefore, the present case is extremely unique in that the patientʼs condition was complicated with CEP. A diagnosis of advanced gallbladder cancer was made in the patientʼs clinical course, suggesting the advisability of a whole-body workup in cases of pSS, especially in elderly patients. |
| キーワード | bronchial alveolar lavage eosinophilic pneumonia eosinophilia interstitial lung diseases Sjögren syndrome |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 123 |
| 終了ページ | 127 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899635 |
| Web of Science KeyUT | 000353181700008 |
| JaLCDOI | 10.18926/AMO/53340 |
|---|---|
| フルテキストURL | 69_2_113.pdf |
| 著者 | Inada, Ryo| Nagasaka, Takeshi| Toshima, Toshiaki| Mori, Yoshiko| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Hiraki, Takao| Oshiro, Taihei| Kanemitsu, Yukihide| Fujiwara, Toshiyoshi| |
| 抄録 | A case of advanced rectal cancer treated by aggressive local and systemic treatment who has survived more than 7 years from initial recurrence is presented. A 55-year-old woman was diagnosed with advanced lower rectal cancer and underwent a low anterior resection with complete removal of all regional lymph nodes and total mesorectal excision. The tumor was diagnosed as a moderately differentiated adenocarcinoma, pStage IIIB (T3, N2a, M0). Twenty-six months after the initial surgery, local recurrence in the pelvis was detected by computed tomography, and total pelvic exenteration with distal sacrectomy (TPES) was performed after systemic chemotherapy with a molecular-targeted drug. Six months after the TPES, multiple lung metastases were detected. Consequently, the patient underwent radiofrequency ablation (RFA) and chemotherapy. The disease has since been controlled for 38 months. As volume control is essential for cancer treatment, it may be important to combine appropriate local therapy with systemic therapy to metastatic or recurrent sites in order to achieve much longer disease control. |
| キーワード | colorectal cancer recurrence total pelvic exenteration radiofrequency ablation systemic chemotherapy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 113 |
| 終了ページ | 118 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899633 |
| Web of Science KeyUT | 000353181700006 |
| タイトル（別表記） | PD-1,CTLA-4 |
|---|---|
| フルテキストURL | 127_63.pdf |
| 著者 | 榮川 伸吾| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-04-01 |
| 巻 | 127巻 |
| 号 | 1号 |
| 開始ページ | 63 |
| 終了ページ | 65 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.63 |
| NAID | 130005068337 |
| タイトル（別表記） | Gene therapy using REIC/Dkk-3-encoding adenoviral vector for the treatment of malignant pleural mesothelioma |
|---|---|
| フルテキストURL | 127_47.pdf |
| 著者 | 豊岡 伸一| |
| キーワード | 悪性胸膜中皮腫 REIC/DKK-3 遺伝子治療 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-04-01 |
| 巻 | 127巻 |
| 号 | 1号 |
| 開始ページ | 47 |
| 終了ページ | 50 |
| ISSN | 0030-1558 |
| 関連URL | http://www.okayama-u.ac.jp/user/oma/ |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.47 |
| NAID | 130005068349 |
| 著者 | Sugihara, Taro| Fujinami, Tsutomu| Jones, Rachel| Kadowaki, Kozo| Ando, Masaya| |
|---|---|
| 発行日 | 2014-09-02 |
| 出版物タイトル | AI & SOCIETY |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/53023 |
|---|---|
| フルテキストURL | 68_6_339.pdf |
| 著者 | Nishie, Hiroyuki| Mizobuchi, Satoshi| Suzuki, Etsuji| Sato, Kenji| Toda, Yuichiro| Matsuoka, Junji| Morimatsu, Hiroshi| |
| 抄録 | The main purpose of this study was to determine the relationships between Japanese individualsʼ interest in living wills and their preferred end-of-life care and death locations. Questionnaires were mailed to 1,000 individuals aged ｧ50 to measure these 2 factors. We examined the associations between the respondentsʼ characteristics and their preferred care and death locations by using multinomial logistic regression models. The response rate was 74%. Home was the most frequently preferred place for end-of-life care (64%), and a palliative care unit (PCU) was the most commonly preferred place to die (51%). Living will interest was associated with a preference for care (odds ratio [OR] 4.74, 95% confidence interval [CI] 1.95-12.1) and death (OR 2.75, 95% CI 1.70-4.47) in a PCU rather than a hospital, but it was not associated with the choice between receiving care or dying at home instead of a hospital. We must consider why Japanese people think home death is impracticable. The Japanese palliative care system should be expanded to meet patientsʼ end-of-life needs, and this includes not only facilitating home care but also increasing access to PCU care. |
| キーワード | advance healthcare directive living will end-of-life care palliative care unit place of death |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-12 |
| 巻 | 68巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 339 |
| 終了ページ | 348 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25519028 |
| Web of Science KeyUT | 000346882200004 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/53134 |
| JaLCDOI | 10.18926/AMO/53021 |
|---|---|
| フルテキストURL | 68_6_323.pdf |
| 著者 | Hirayama, Takahiro| Nagano, Osamu| Shiba, Naoki| Yumoto, Tetsuya| Sato, Keiji| Terado, Michihisa| Ugawa, Toyomu| Ichiba, Shingo| Ujike, Yoshihito| |
| 抄録 | In adult high-frequency oscillatory ventilation (HFOV), stroke volume (SV) and mean lung pressure (PLung) are important for lung protection. We measured the airway pressure at the Y-piece and the lung pressure during HFOV using a lung model and HFOV ventilators for adults (R100 and 3100B). The lung model was made of a 20-liter, airtight rigid plastic container (adiabatic compliance: 19.3ml/cmH2O) with or without a resistor (20cmH2O/l/sec). The ventilator settings were as follows: mean airway pressure (MAP), 30cmH2O;frequency, 5-15Hz (every 1Hz);airway pressure amplitude (AMP), maximum;and % of inspiratory time (IT), 50% for R100, 33% or 50% for 3100B. The measurements were also performed with an AMP of 2/3 or 1/3 maximum at 5, 10 and 15Hz. The PLung and the measured MAP were not consistently identical to the setting MAP in either ventilator, and decreasing IT decreased the PLung in 3100B. In conclusion, we must pay attention to the possible discrepancy between the PLung and the setting MAP during adult HFOV. |
| キーワード | HFOV mean lung pressure mean airway pressure |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-12 |
| 巻 | 68巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 323 |
| 終了ページ | 329 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25519026 |
| Web of Science KeyUT | 000346882200002 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/53132 |
| 著者 | Hiasa, Miki| Miyaji, Takaaki| Haruna, Yuka| Takeuchi, Tomoya| Harada, Yuika| Moriyama, Sawako| Yamamoto, Akitsugu| Omote, Hiroshi| Moriyama, Yoshinori| |
|---|---|
| 発行日 | 2014-10-30 |
| 出版物タイトル | Scientific Reports |
| 巻 | 4巻 |
| 資料タイプ | 学術雑誌論文 |
| タイトル（別表記） | Induction therapy followed by surgery for non small-cell lung cancer |
|---|---|
| フルテキストURL | 126_103.pdf |
| 著者 | 豊岡 伸一| |
| キーワード | 非小細胞肺癌 導入療法 放射線化学療法 外科切除 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2014-08-01 |
| 巻 | 126巻 |
| 号 | 2号 |
| 開始ページ | 103 |
| 終了ページ | 107 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2014 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.126.103 |
| NAID | 130004685260 |
| タイトル（別表記） | The 2013 Incentive Award of the Okayama Medical Association in Cancer Research (2013 Hayashibara Prize and Yamada Prize) |
|---|---|
| フルテキストURL | 126_87.pdf |
| 著者 | 宮原 孝治| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2014-08-01 |
| 巻 | 126巻 |
| 号 | 2号 |
| 開始ページ | 87 |
| 終了ページ | 88 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2014 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.126.87 |
| NAID | 120005468244 |
| 著者 | 佐藤 勝紀| |
|---|---|
| 発行日 | 2014-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 30巻 |
| 資料タイプ | その他 |
| 著者 | Putranto, Endy Widya| Murata, Hitoshi| Yamamoto, Ken-Ichi| Kataoka, Ken| Yamada, Hidenori| Futami, Jun-Ichiro| Sakaguchi, Masakiyo| Huh, Nam-Ho| |
|---|---|
| 発行日 | 2013-10 |
| 出版物タイトル | International Journal of Molecular Medicine |
| 巻 | 32巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Muraoka, Takayuki| Soh, Junichi| Toyooka, Shinichi| Aoe, Keisuke| Fujimoto, Nobukazu| Hashida, Shinsuke| Maki, Yuho| Tanaka, Norimitsu| Shien, Kazuhiko| Furukawa, Masashi| Yamamoto, Hiromasa| Asano, Hiroaki| Tsukuda, Kazunori| Kishimoto, Takumi| Otsuki, Takemi| Miyoshi, Shinichiro| |
|---|---|
| 発行日 | 2013-12 |
| 出版物タイトル | Lung Cancer |
| 巻 | 82巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/51864 |
|---|---|
| フルテキストURL | 67_5_285.pdf |
| 著者 | Akita, Mitsuhiro| Hiraoka, Sakiko| Kaji, Eisuke| Takemoto, Koji| Nagahara, Yasuhiro| Yamamoto, Hiroshi| Yamamoto, Kazuhide| Kato, Jun| |
| 抄録 | Whether presence or history of extracolonic primary malignancy is a risk for colorectal neoplasia is not fully known. In this study, 26,452 first-time colonoscopy cases were examined using a colonoscopy database. Among the analyzed subjects, 3,026 (11%) subjects had history or concomitance of extracolonic primary malignancy, while the remaining 23,426 subjects did not. Colorectal neoplasia was observed in 39% of all the subjects. A crude comparison showed that the prevalence of any type of colorectal neoplasia was higher in subjects with extracolonic malignancy than in those without (42% vs. 39%, p＝0.0012). However, after adjusting for confounding factors, the odds ratios (ORs) of subjects with extracolonic malignancy for having colorectal neoplasia, advanced neoplasia, and cancer were all less than 1.0, and all significantly different from those of subjects without extracolonic malignancy. Analysis according to the type of extracolonic malignancy revealed that gastric cancer cases had a significantly lower risk for colorectal advanced neoplasia (OR:0.81;95% CI:0.67-0.99). Among major malignancies, only esophageal squamous cell cancer cases had increased risk for colorectal neoplasia (OR:1.66;95% CI:1.20-2.29). Patients with presence or history of extracolonic malignancy did not carry a higher risk of occurrence of colorectal neoplasia. |
| キーワード | colorectal cancer colonoscopy risk factor database |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-10 |
| 巻 | 67巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 285 |
| 終了ページ | 292 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24145728 |
| Web of Science KeyUT | 000325836100002 |
| 著者 | Nishikawa, Toshio| Takaoka, Munenori| Ohara, Toshiaki| Tomono, Yasuko| Hao, Huifang| Bao, Xiaohong| Fukazawa, Takuya| Wang, Zhigang| Sakurama, Kazufumi| Fujiwara, Yasuhiro| Motoki, Takayuki| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Tanaka, Noriaki| Fujiwara, Toshiyoshi| Naomoto, Yoshio| |
|---|---|
| 発行日 | 2013-03 |
| 出版物タイトル | Cancer Biology & Therapy |
| 巻 | 14巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Matsuura, Koji| Naruse, Keiji| |
|---|---|
| 発行日 | 2012-09-12 |
| 出版物タイトル | Advanced Elastomers - Technology, Properties and Applications |
| 資料タイプ | 図書 |
| JaLCDOI | 10.18926/AMO/51067 |
|---|---|
| フルテキストURL | 67_4_227.pdf |
| 著者 | Ryuko, Hiromasa| Otsuka, Fumio| |
| 抄録 | Primary care physicians often encounter patients with fever of unknown origin and without apparent causes. Recent advances in laboratory medicine have facilitated diagnostic procedures;however, it is still difficult to determine the critical febrile factor at an early stage. We reviewed the medical records of 174 patients who were admitted due to a chief complaint of fever (＞37.5℃) to our hospital during the period from 2004 to 2010. The patients were categorized into patients with infection, inflammation, neoplasm and drug-induced fever. Based on the analysis done by category, it was revealed that the patient's age, body temperature and duration of fever were closely related to the final diagnosis. Serum CRP levels were significantly low in the nonbacterial infection group, while serum levels of sIL-2R were high in neoplasm and drug-induced cases. CRP level on admission was weakly but significantly correlated with body temperature, while duration of fever was inversely related to body temperature. The effectiveness of PET-CT and tissue biopsy for diagnosis was considerably high, particularly in the categories of neoplasm and nonspecific inflammation, respectively, though the effectiveness of bacterial culture was low. Thus, a careful review of physical and laboratory information including body temperature, CRP level, duration of fever, gender difference and history of medication is indispensable for diagnosis. Stepwise categorization and disease classification by comprehensive and systemic checkup are very helpful for determining the causes of fever. |
| キーワード | computed tomography (CT) C-reactive protein (CRP) fluorodeoxyglucose positron emission tomography (FDG-PET) fever of unknown origin (FUO) soluble interleukin-2 receptor (sIL-2R) |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-08 |
| 巻 | 67巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 227 |
| 終了ページ | 237 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23970321 |
| Web of Science KeyUT | 000323470100004 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/51947 |
| 著者 | 永坂 岳司| 藤原 俊義| |
|---|---|
| 発行日 | 2013-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 125巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/49665 |
|---|---|
| フルテキストURL | 67_2_75.pdf |
| 著者 | Otsuka, Fumio| |
| 抄録 | New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiological inhibitor of luteinization in growing ovarian follicles. In the ovary, the expression of oocyte-derived BMP-15 is critical for female reproduction. In the pituitary, BMP-4 is a key player for initial development of the anterior pituitary, while it is also functionally involved in some differentiated pituitary tumors, including prolactinoma and Cushingʼs disease. In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. In the present review, recent advances in BMP biology in the field of endocrinology are described and the possibility for clinical application of BMP activity is discussed. |
| キーワード | bone morphogenetic protein folliculogenesis pituitary adenoma steroidogenesis transforming growth factor |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-04 |
| 巻 | 67巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 75 |
| 終了ページ | 86 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23603923 |
| Web of Science KeyUT | 000317801700001 |