検索結果 800 件
| JaLCDOI | 10.18926/AMO/48686 |
|---|---|
| フルテキストURL | 66_4_317.pdf |
| 著者 | Pak, Wing| Takayama, Fusako| Hasegawa, Azusa| Mankura, Mitsumasa| Egashira, Toru| Ueki, Keiji| Nakamoto, Kazuo| Kawasaki, Hiromu| Mori, Akitane| |
| 抄録 | This study aimed to investigate the therapeutic effects of the water extract of leaves of Vitis coignetiae Pulliat (VCPL) on nonalcoholic steatohepatitis (NASH) with advanced fibrosis, as our previous study exhibited its preventive effect on NASH. The NASH animal model [PCT/JP2007/52477] was prepared by loading recurrent and intermittent hypoxemia stress to a rat with fatty liver, which resembled the condition occurring in patients with obstructive sleep apnea (OSA) and fatty liver, who have a high incidence of NASH. Intermittent hypoxemia stress is regarded as a condition similar to warm ischemia followed by re-oxygenation, which induces oxidative stress (OS). The daily 100 or 300mg/kg VCPL administrations were performed for 3 weeks perorally beginning at the time of detection of advanced liver fibrosis. The therapeutic efficacy of VCPL on NASH was demonstrated by the reduction of the leakage of hepato-biliary enzymes and the amelioration of liver fibrosis. The OS elevation in NASH rats was measured based on the derivation of reactive oxygen species from liver mitochondrial energy metabolism and on the decrease in plasma SOD-like activity. The aggravation of inflammatory responses was demonstrated by the neutrophil infiltration (elevated myeloperoxidase activity) and the progression of fibrosis in the livers of NASH rats. In addition, the NASH rats without VCPL treatment also exhibited activation of nuclear factor-κB, a key factor in the link between oxidative stress and inflammation. All of these changes were reduced dose-dependently by the VCPL administration. These findings indicate that VCPL may improve hepatic fibrosis or at least suppress the progression of NASH, by breaking the crosstalk between OS and inflammation. |
| キーワード | non-alcoholic steatohepatitis antioxidative oxidative stress anti-inflammation Vitis coignetiae Pulliat |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-08 |
| 巻 | 66巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 317 |
| 終了ページ | 327 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22918204 |
| Web of Science KeyUT | 000307918900004 |
| 著者 | 西崎 正彦| 藤原 康宏| 丁田 泰宏| 金澤 卓| 二宮 基樹| 藤原 俊義| |
|---|---|
| 発行日 | 2012-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 124巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 平尾 謙| |
|---|---|
| 発行日 | 2011-12-31 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | Kusumoto, Kenji| Murakami, Yousuke| Otsuki, Mariko| Kanayama, Munetoshi| Takeuchi, Sakae| Takahashi, Sumio| |
|---|---|
| 発行日 | 2005-09 |
| 出版物タイトル | Zoological Science |
| 巻 | 22巻 |
| 号 | 9号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Rajapakse, Sanath| Ogiwara, Katsueki| Yamano, Noriko| Kimura, Atsushi| Hirata, Kensaku| Takahashi, Sumio| Takahashi, Takayuki| |
|---|---|
| 発行日 | 2006-11 |
| 出版物タイトル | Zoological Science |
| 巻 | 23巻 |
| 号 | 11号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Singaravel, Muniyandi| Fujisawa, Yuko| Hisada, Miki| Saifullah, ASM| Tomioka, Kenji| |
|---|---|
| 発行日 | 2003-11 |
| 出版物タイトル | Zoological Science |
| 巻 | 20巻 |
| 号 | 11号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/47262 |
|---|---|
| フルテキストURL | 65_6_369.pdf |
| 著者 | Terada, Chuji| Yoshida, Aki| Nasu, Yoshihisa| Mori, Shuji| Tomono, Yasuko| Tanaka, Masato| Takahashi, Hideo K.| Nishibori, Masahiro| Ozaki, Toshifumi| Nishida, Keiichiro| |
| 抄録 | We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade of cartilage destruction, and examined the role of HMGB-1 in the regulation of proinflammatory cytokine expression in chondrocytes. An immunohistochemical study demonstrated that total HMGB-1-positive cell ratios increase as the Osteoarthritis Research Society International (OARSI) histological grade increased. The population of cytoplasmic HMGB-1-positive chondrocytes was especially increased in the deep layers of higher-grade cartilage. The ratios and localization of receptors for advanced glycation end products (RAGE) expression by chondrocytes in Grade 2, 3, and 4 were significantly higher than those in Grade 1. In vitro stimulation with IL-1β, but not TNFα, significantly upregulated the expression of HMGB-1 mRNA by human OA chondrocytes. Both IL-1β and TNFα promoted the translocation of HMGB-1 from nuclei to cytoplasm. IL-1β and TNFα secretions were stimulated at higher levels of HMGB-1. The results of our study suggest the involvement of HMGB-1 in the pathogenesis of cartilage destruction in OA. |
| キーワード | HMGB-1 RAGE chondrocyte osteoarthritis cartilage |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-12 |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 369 |
| 終了ページ | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189477 |
| Web of Science KeyUT | 000298516900003 |
| 著者 | 佐藤 太祐| 八木 孝仁| 貞森 裕| 楳田 祐三| 藤原 俊義| |
|---|---|
| 発行日 | 2011-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/47013 |
|---|---|
| フルテキストURL | 65_5_315.pdf |
| 著者 | Wang, Lei| Kaku, Haruki| Huang, Peng| Xu, Kexin| Yang, Kai| Zhang, Jiheng| Li, Ming| Xie, Liping| Wang, Xiaofeng| Sakai, Akiko| Watanabe, Masami| Nasu, Yasutomo| Shimizu, Kenji| Kumon, Hiromi| Na, Yanqun| |
| 抄録 | Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR＝0.58, 95%CI:0.35-0.97, p＝0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR＝0.27, 95%CI:0.12-0.61, p＝0.002) and in patients with localized diseases (OR＝0.36, 95%CI:0.19-0.70, p＝0.003). However, no statistically significant difference was found in the subgroup with age ＞72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects. |
| キーワード | polymorphism prostatic neoplasms single nucleotide susceptibility WRN |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 315 |
| 終了ページ | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037267 |
| Web of Science KeyUT | 000296116400005 |
| 著者 | Hanafusa, Tadashi| Mohamed, Ali Eldib Ali| Kitaoka, Kenta| Ohue, Yoshihiro| Nakayama, Eiichi| Ono, Toshiro| |
|---|---|
| 発行日 | 2011-02-01 |
| 出版物タイトル | Cancer Letters |
| 巻 | 301巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Kawakami, Keisuke| Umena, Yasufumi| Kamiya, Nobuo| Shen, Jian-Ren| |
|---|---|
| 発行日 | 2011 |
| 出版物タイトル | Journal of Photochemistry and Photobiology B: Biology |
| 巻 | 104巻 |
| 号 | 1-2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Furumatsu, Takayuki| Shukunami, Chisa| Amemiya-Kudo, Michiyo| Shimano, Hitoshi| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2010-01 |
| 出版物タイトル | The International Journal of Biochemistry & Cell Biology |
| 巻 | 42巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 黒田 新士| 藤原 俊哉| 白川 靖博| 山崎 泰源| 矢野 修也| 宇野 太| 田澤 大| 橋本 悠里| 渡辺 雄一| 野間 和広| 浦田 泰生| 香川 俊輔| 藤原 俊義| |
|---|---|
| 発行日 | 2011-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 秋山 麻里| 小林 勝弘| 吉永 治美| 大塚 頌子| |
|---|---|
| 発行日 | 2011-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/46628 |
|---|---|
| フルテキストURL | 65_3_169.pdf |
| 著者 | Takeda, Masanori| Nagasaka, Takeshi| Dong-Sheng, Sun| Nishie, Hiroyuki| Oka, Tetsuhiro| Yamada, Eiji| Mori, Yoshiko| Shigeyasu, Kunitoshi| Morikawa, Tatsuya| Mizobuchi, Satoshi| Fujiwara, Toshiyoshi| |
| 抄録 | Secreted frizzled-related protein 2, (SFRP2) is a Wnt inhibitor whose promoter CpGs were recently found to be methylated at high frequency in colorectal cancers (CRCs). We hypothesized that the pattern of SFRP2 methylation may differ throughout the promoter during progressive tumorigenesis. Using combined bisulfite restriction analysis (COBRA), two methylation-sensitive regions (Regions A and B) of the SFRP2 promoter were investigated in 569 specimens of colorectal tissue:222 CRCs, 103 adenomatous polyps (APs), 208 normal colonic mucosa from CRC patients (N-Cs), and 36 normal colonic mucosa from subjects with no evidence of colorectal neoplasia at colonoscopy (N-Ns). Extensive (including both Regions A and B) and partial (either Region A or B) SFRP2 methylation levels were found in 61.7% and 24.8% of CRCs, 8.7% and 37.9% of APs, 3.9% and 39.9% of N-Cs, and 0% and 30.6% of N-Ns, respectively. Extensive methylation of the SFRP2 promoter was present primarily in CRCs, while partial methylation was common in APs. Whereas APs with the KRAS mutant showed no correlation to any pattern of SFRP2 methylation, extensive methylation of the SFRP2 promoter was significantly associated with KRAS mutant CRCs (p＜.0001), suggesting that genetic alteration in the RAS-RAF pathway might precede the spread of CpG methylation through the SFRP2 promoter, which is observed in over 60% of advanced colorectal tumors. |
| キーワード | BRAF/KRAS mutations promoter methylation colorectal cancer |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-06 |
| 巻 | 65巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 169 |
| 終了ページ | 177 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21709714 |
| Web of Science KeyUT | 000292017500003 |
| 著者 | 樅木 勝巳| 高嶋 留美| 松川 昭博| |
|---|---|
| 発行日 | 2011-05 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 27巻 |
| 資料タイプ | 一般雑誌記事 |
| 著者 | 樅木 勝巳| 落合 和彦| |
|---|---|
| 発行日 | 2009-03 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 25巻 |
| 資料タイプ | 一般雑誌記事 |
| JaLCDOI | 10.18926/AMO/45267 |
|---|---|
| フルテキストURL | 65_2_91.pdf |
| 著者 | Nagamatsu, Tomohiro| Sakoda, Akihiro| Kataoka, Takahiro| Ono, Toshiro| Yamaoka, Kiyonori| |
| 抄録 | No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics. |
| キーワード | tobacco radionuclides smoking intake radiation exposure |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-04 |
| 巻 | 65巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 91 |
| 終了ページ | 95 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21519366 |
| Web of Science KeyUT | 000289818800004 |
| JaLCDOI | 10.18926/AMO/45265 |
|---|---|
| フルテキストURL | 65_2_71.pdf |
| 著者 | Sato, Kimiko| Oda, Megumi| |
| 抄録 | A questionnaire survey was administered to 317 parents who attended infant health check-ups in City B, Okayama Prefecture between October, 2008 and March, 2009. The questionnaire survey studied 7 factors based on the PRECEDE-PROCEED Model. We analysed factors that affected oral health behaviour and attendance at scheduled dental health check-ups. The survey containing 22 items concerning matters such as 'QOL' and 'health problems' was posted to parents and guardians in advance, and then collected on the day of the medical check-up. The collected data was analysed using the t-test and Pearson's correlation coefficient, following which we conducted a covariance structure analysis. The results showed that dental health behaviour was directly affected by reinforcing factors, and indirectly associated with enabling and predisposing factors influenced by reinforcing factors. It was also shown that predisposing factors and oral health behaviour were associated with attendance at scheduled oral health check-ups. The results indicated that strengthening oral health education by sharing knowledge that acts as predisposing factors and introducing adaptations of oral health behaviour that that fit individual lives will lead to improved attendance at scheduled dental health check-ups. |
| キーワード | PRECEDE-PROCEED model dental check-ups dental health behaviour |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-04 |
| 巻 | 65巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 71 |
| 終了ページ | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 21519364 |
| Web of Science KeyUT | 000289818800002 |
| JaLCDOI | 10.18926/fest/44791 |
|---|---|
| タイトル（別表記） | The Changes and Problems of Commercial Activities in terms of the Questionnaire Survey in Omote-cho as the Central Shopping Street in Okayama City |
| フルテキストURL | fest_016_007_033.pdf |
| 著者 | 韩 静| 市南 文一| |
| 抄録 | The present study mainly studied some properties of retail stores on the central shopping streets in Okayama City while looking back on the transition of the commerce. Second, we investigated the actual conditions of most retail stores in Omote-cho in terms of the questionnaire survey. Third, we considered the problems and measures on retail stores, a little. The charm of the central shopping streets has decreased relatively in Okayama City due to the advancement of a large-scale stores and the location competition of convenience stores. The number of empty stores has increased and the amount of the pedestrian traffic, the value of sales, and the number of retail stores have shown the decreasing tendency in eight commercial blocs in Omote-cho. Therefore, the unique features in Omote-cho should be polished while esteeming the history and the culture. The charm and/or the atmosphere of traditional commercial blocs is requested to be created while sending new informations that continue to create young person's fashion and culture. |
| キーワード | Retail Stores Central Shopping Street Questionnaire Survey Omote-cho Okayama City |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 発行日 | 2011-03-18 |
| 巻 | 16巻 |
| 号 | 1号 |
| 開始ページ | 7 |
| 終了ページ | 33 |
| ISSN | 2185-3347 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002949471 |