検索結果 800 件
| フルテキストURL | Int_J_Spce_Situat_Comput_7_3_145.pdf |
|---|---|
| 著者 | Khin Khin Zaw| Funabiki, Nobuo| |
| キーワード | Java programming learning assistant system JPLAS design-aware test code JUnit metric plugin breadth-first-search BFS |
| 発行日 | 2017-12-29 |
| 出版物タイトル | International Journal of Space-Based and Situated Computing |
| 巻 | 7巻 |
| 号 | 3号 |
| 出版者 | INDERSCIENCE ENTERPRISES |
| 開始ページ | 145 |
| 終了ページ | 154 |
| ISSN | 2044-4893 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1504/IJSSC.2017.089006 |
| 関連URL | isVersionOf https://doi.org/10.1504/IJSSC.2017.089006 |
| フルテキストURL | IJCSE17_2_116_2017.pdf |
|---|---|
| 著者 | Ishihara, Nobuya| Funabiki, Nobuo| Kuribayashi, Minoru| Kao, Wen-Chung| |
| キーワード | JPLAS Java programming education Web application MVC model Software architecture |
| 発行日 | 2017-07-27 |
| 出版物タイトル | International Journal of Computer & Software Engineering |
| 巻 | 2巻 |
| 号 | 1号 |
| 出版者 | Graphy Publications |
| 開始ページ | 116 |
| ISSN | 2456-4451 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| DOI | 10.15344/2456-4451/2017/116 |
| 関連URL | isVersionOf https://doi.org/10.15344/2456-4451/2017/116 |
| フルテキストURL | TransJSASS_12_85.pdf |
|---|---|
| 著者 | Kouchi, Toshinori| Oka, Yoshinori| Masuya, Goro| Yanase, Shinichiro| |
| キーワード | Advanced Laser Diagnostics Turbulent Mixing Turbulent Eddy Diffusive Flux Supersonic Combustor Scramjet |
| 発行日 | 2014-12-03 |
| 出版物タイトル | Transactions of the Japan Society for Aeronautical and Space Sciences, Aerospace Technology Japan |
| 巻 | 12巻 |
| 号 | APISAT-2013号 |
| 出版者 | The Japan Society for Aeronautical and Space Sciences |
| 開始ページ | a85 |
| 終了ページ | a92 |
| ISSN | 1884-0485 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| DOI | 10.2322/tastj.12.a85 |
| 関連URL | isVersionOf https://doi.org/10.2322/tastj.12.a85 |
| フルテキストURL | PlosOne_2018_e0191109.pdf |
|---|---|
| 著者 | Eguchi, Takanori| Sogawa, Chiharu| Okusha, Yuka| Uchibe, Kenta| Iinuma, Ryosuke| Ono, Kisho| Nakano, Keisuke| Murakami, Jun| Itoh, Manabu| Arai, Kazuya| Fujiwara, Toshifumi| Namba, Yuri| Murata, Yoshiki| Ohyama, Kazumi| Shimomura, Manami| Okamura, Hirohiko| Takigawa, Masaharu| Nakatsura, Tetsuya| Kozaki, Kenichi| Okamoto, Kuniaki| Calderwood, Stuart K.| |
| 発行日 | 2018-02-07 |
| 出版物タイトル | PlosOne |
| 巻 | 13巻 |
| 号 | 2号 |
| 出版者 | Public Library Science |
| 開始ページ | e0191109 |
| ISSN | 19326203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | publisher |
| PubMed ID | 29415026 |
| DOI | 10.1371/journal.pone.0191109 |
| Web of Science KeyUT | 000424325300015 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0191109 |
| フルテキストURL | J_Cell_Biochem_201805_27040.pdf |
|---|---|
| 著者 | Okusha, Yuka| Eguchi, Takanori| Sogawa, Chiharu| Okui, Tatsuo| Nakano, Keisuke| Okamoto, Kuniaki| Kozaki, Ken‐Ichi| |
| キーワード | PEX domain cancer metastasis non-proteolytic MMP nuclear MMP tumor stroma |
| 発行日 | 2018-05-15 |
| 出版物タイトル | Journal of Cellular Biochemistry |
| 巻 | 119巻 |
| 号 | 9号 |
| 出版者 | Wiley |
| 開始ページ | 7363 |
| 終了ページ | 7376 |
| ISSN | 1097-4644 |
| NCID | AA1052210X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 29761931 |
| DOI | 10.1002/jcb.27040 |
| Web of Science KeyUT | 000445187800024 |
| 関連URL | isVersionOf https://doi.org/10.1002/jcb.27040 |
| フルテキストURL | J_Cell_Biochem_118_1_43.pdf |
|---|---|
| 著者 | Eguchi, Takanori| Calderwood, Stuart K.| Takigawa, Masaharu| Kubota, Satoshi| Kozaki, Ken‐ichi| |
| キーワード | CBXs CHROMOBOX PROTEINS HEAT SHOCK FACTOR 1 HEAT SHOCK PROTEINS HETEROCHROMATIN PROTEINS HP1 HSF1 HSPs MATRIX METALLOPROTEINASE MMP3 TRANSCRIPTION |
| 発行日 | 2016-05-21 |
| 出版物タイトル | Journal of Cellular Biochemistry |
| 巻 | 118巻 |
| 号 | 1号 |
| 出版者 | Wiley |
| 開始ページ | 43 |
| 終了ページ | 51 |
| ISSN | 07302312 |
| NCID | AA1052210X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 27206651 |
| DOI | 10.1002/jcb.25607 |
| Web of Science KeyUT | 000387809300005 |
| 関連URL | isVersionOf https://doi.org/10.1002/jcb.25607 |
| JaLCDOI | 10.18926/AMO/56080 |
|---|---|
| フルテキストURL | 72_3_319.pdf |
| 著者 | Makimoto, Go| Ichihara, Eiki| Hotta, Katsuyuki| Ninomiya, Kiichiro| Oze, Isao| Minami, Daisuke| Ninomiya, Takashi| Kubo, Toshio| Ohashi, Kadoaki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| 抄録 | Although cisplatin-based chemotherapy shows a survival advantage compared to carboplatin for treating advanced non-small cell lung cancer, high-volume hydration and a long infusion time are necessary to avoid nephrotoxicity, and cisplatin-based chemotherapy has been difficult to administer in outpatient settings. A low-volume hydration method using mannitol or furosemide as forced diuresis was recently introduced, but there are no clear conclusions regarding which agent should be used. We describe our ongoing randomized phase II trial (the OLCSG1406 Study) evaluating the efficacy of forced diuresis. This study will clarify whether mannitol or furosemide is more suitable in cisplatin-based chemotherapy with low-volume hydration. |
| キーワード | cisplatin mannitol furosemide lung cancer hydration non-small cell lung cancer |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 319 |
| 終了ページ | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926012 |
| フルテキストURL | Biochem_Biophy_Res_Comm_201807.pdf |
|---|---|
| 著者 | Fujiwara, Toshifumi| Eguchi, Takanori| Sogawa, Chiharu| Ono, Kisho| Murakami, Jun| Ibaragi, Soichiro| Asaumi, Jun-ichi| Okamoto, Kuniaki| Calderwood, Stuart K.| Kozaki, Ken-ichi| |
| キーワード | Extracellular vesicles Anti-EGFR antibody therapy Cetuximab Epithelial-to-mesenchymal transition Head and neck squamous cell carcinoma |
| 発行日 | 2018-07-13 |
| 出版物タイトル | Biochemical and Biophysical Research Communications A |
| 出版者 | Elsevier |
| ISSN | 0006291X |
| NCID | AA00564395 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 論文のバージョン | publisher |
| DOI | 10.1016/j.bbrc.2018.07.035 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.bbrc.2018.07.035 |
| タイトル（別表記） | Thirty-five years activities of Okayama Association for Laboratory Animal Science |
|---|---|
| フルテキストURL | poalas_034_054.pdf |
| 著者 | 佐藤 勝紀| |
| 抄録 | The Okayama Association for Laboratory Science, established on December 7, 1982, celebrates its 35th anniversary on December 7, 2017. The association was established to provide opportunities for researchers interested in laboratory animals and animal experiments to assemble beyond the borders of universities, faculties, and institutions to exchange their knowledge and information, as well as help promote their research activities and advancement of community science. The executives, auditors, and other members of the association have organized and held workshops and issued newsletters under the leadership of former presidents. The association has been able to implement research activities for a long period of time thanks to the advice of regular members and the support of supporting members. The workshops have been held twice a year since 1990. A total of 74 workshops(regular conferences), as well as symposiums, have been held and 33 research bulletins (proceedings) have been issued over the last 35 years. We have summarized the workshops and symposiums etc. that have been held. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2018-04 |
| 巻 | 34巻 |
| 開始ページ | 54 |
| 終了ページ | 73 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | K0005661_abstract_review.pdf K0005661_summary.pdf K0005661_fulltext.pdf |
|---|---|
| 著者 | 田村 朋季| |
| 発行日 | 2018-03-23 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5661号 |
| 学位授与年月日 | 2018-03-23 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005641_abstract_review.pdf K0005641_summary.pdf K0005641_fulltext.pdf |
|---|---|
| 著者 | 森岡 祐太| |
| 発行日 | 2017-12-27 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5641号 |
| 学位授与年月日 | 2017-12-27 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| JaLCDOI | 10.18926/AMO/55669 |
|---|---|
| フルテキストURL | 72_1_85.pdf |
| 著者 | Kosaki, Yoshinori| Yumoto, Tetsuya| Naito, Hiromichi| Tsuboi, Nobushige| Kameda, Masahiro| Hirano, Masayuki| Morizane, Yuki| Senoo, Takaya| Tokuyama, Eijirou| Nakao, Atsunori| |
| 抄録 | Traumatic eyeball luxation is a rare clinical condition with a dramatic presentation. Here, we describe a unique case of traumatic globe luxation and complete optic nerve transection caused by heavy object compression. A 45-year-old male automobile mechanic was injured when a truck slipped from its supports, crushing his head and face. On arrival, his right eyeball was obviously displaced anteriorly and he had no light perception. Computed tomography revealed complex frontal bone and facial fractures with underlying brain contusion in addition to complete transection of the right optic nerve. The patient was successfully treated using a multidisciplinary approach. |
| キーワード | globe luxation optic nerve avulsion traumatic brain injury facial trauma |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-02 |
| 巻 | 72巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 85 |
| 終了ページ | 88 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29463945 |
| フルテキストURL | PhysRevB_95_245310.pdf |
|---|---|
| 著者 | Uesugi, Eri| Miao, Xiao| Ota, Hiromi| Goto, Hidenori| Kubozono, Yoshihiro| |
| 備考 | This is an article published by American Physical Society| |
| 発行日 | 2017-01 |
| 出版物タイトル | Physical Review B |
| 巻 | 95巻 |
| 号 | 24号 |
| 出版者 | American Physical Society |
| 開始ページ | 245310 |
| ISSN | 2469-9950 |
| NCID | AA11187113 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | American Physical Society |
| 論文のバージョン | publisher |
| DOI | 10.1103/PhysRevB.95.245310 |
| Web of Science KeyUT | 000403355300005 |
| 関連URL | isVersionOf https://doi.org/10.1103/PhysRevB.95.245310 |
| フルテキストURL | APL_111_243106_2017.pdf |
|---|---|
| 著者 | Ishikawa, Atsushi| Hara, Shuhei| Tanaka, Takuo| Zhan, Xiang| Tsuruta, Kenji| |
| 備考 | This is an Accepted Manuscript of an article published by American Institute of Physics| |
| 発行日 | 2017-12-11 |
| 出版物タイトル | Applied Physics Letters |
| 巻 | 111巻 |
| 号 | 24号 |
| 出版者 | American Institute of Physics |
| 開始ページ | 243106 |
| ISSN | 0003-6951 |
| NCID | AA00543431 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 日本語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| DOI | 10.1063/1.5004703 |
| Web of Science KeyUT | 000418098900036 |
| 関連URL | isVersionOf https://doi.org/10.1063/1.5004703 |
| タイトル（別表記） | Two cases of solid-pseudopapillary neoplasm of the pancreas with contrasting imaging findings |
|---|---|
| フルテキストURL | 129_171.pdf |
| 著者 | 河合 毅| 遠藤 芳克| 渡邉 貴紀| 甲斐 恭平| 佐藤 四三| |
| 抄録 | A solid pseudo-papillary tumor of the pancreas is a rare neoplasm which mainly occurs in young women. Here, we report two cases of solid-pseudopapillary neoplasm of the pancreas (SPN) with contrasting imaging findings. One was a 59-year-old woman having no symptomatic complaint with a pancreatic cystic tumor in the tail. The tumor was 60 mm in diameter with a cyst composed of a calcified wall and low-density content which was poorly perfused on contrast-enhanced computed tomography (CT). We diagnosed SPN based on imaging findings and performed distal pancreatectomy. Histology revealed SPN, and the patient had two years of recurrence -free survival (RFS). The other case was a 34-year-old man with an asymptomatic solid tumor in the pancreatic tail. Contrast-enhanced CT showed low peripheral attenuation of a 25-mm solid tumor, with the main duct dilated distal from tumor. We diagnosed him with pancreatic cancer with atypical image findings. Pathological findings revealed SPN, and the patient had five years of RFS. Small-sized SPN is being increasingly recognized because of the recent advances in CT and MRI. We should consider SPN even if it occurs in a male, and endoscopic ultrasound -guided fine-needle aspiration has recently been reported to be useful in diagnosing SPN. |
| キーワード | 膵SPN（solid-pseudopapillary neoplasm of the pancreas） EUS-FNA（endoscopic ultrasound-guided fine needle aspiration） 成人男性（male） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2017-12-01 |
| 巻 | 129巻 |
| 号 | 3号 |
| 開始ページ | 171 |
| 終了ページ | 177 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.129.171 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2017 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.129.171 |
| NAID | 40021393857 |
| JaLCDOI | 10.18926/AMO/55582 |
|---|---|
| フルテキストURL | 71_6_459.pdf |
| 著者 | Sakaguchi, Masakiyo| Kinoshita, Rie| Endy Widya Putranto| I Made Winarsa Ruma| I Wayan Sumardika| Youyi, Chen| Tomonobu, Naoko| Yamamoto, Ken-ichi| Murata, Hitoshi| |
| 抄録 | The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane. It was first pointed out in 2008 that RAGE’s cytoplasmic tail is able to recruit Diaphanous-1 (Dia-1), resulting in the acquisition of increased cellular motility through Rac1/Cdc42 activation. We also observed that within the cytosol, RAGE’s cytoplasmic tail behaves similarly to a Toll-like receptor (TLR4)-TIR domain, interacting with TIRAP and MyD88 adaptor molecules that in turn activate multiple downstream signals. Subsequent studies demonstrated the presence of an alternative adaptor molecule, DAP10, on the plasma membrane. The coupling of RAGE with DAP10 is critical for enhancing the RAGE-mediated survival signal. Interestingly, RAGE interaction on the membrane was not restricted to DAP10 alone. The chemotactic G-protein-coupled receptors (GPCRs) formyl peptide receptors1 and 2 (FPR1 and FPR2) also interacted with RAGE on the plasma membrane. Binding interaction between leukotriene B4 receptor 1 (BLT1) and RAGE was also demonstrated. All of the interactions affected the RAGE signal polarity. These findings indicate that functional interactions between RAGE and various molecules within the cytoplasmic area or on the membrane area coordinately regulate multiple ligand-mediated RAGE responses, leading to typical cellular phenotypes in several pathological settings. Here we review RAGE’s signaling diversity, to contribute to the understanding of the elaborate functions of RAGE in physiological and pathological contexts. |
| キーワード | receptor for advanced glycation end products RAGE adaptor protein signal transduction inflammatory pathogenesis |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-12 |
| 巻 | 71巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 459 |
| 終了ページ | 465 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29276218 |
| JaLCDOI | 10.18926/AMO/55433 |
|---|---|
| フルテキストURL | 71_5_363.pdf |
| 著者 | Yumoto, Tetsuya| Kosaki, Yoshinori| Yamakawa, Yasuaki| Iida, Atsuyoshi| Yamamoto, Hirotsugu| Yamada, Taihei| Tsukahara, Kohei| Naito, Hiromichi| Osako, Takaaki| Nakao, Atsunori| |
| 抄録 | Worldwide, hemorrhagic shock in major trauma remains a major potentially preventable cause of death. Controlling bleeding and subsequent coagulopathy is a big challenge. Immediate assessment of unidentified bleeding sources is essential in blunt trauma patients with hemorrhagic shock. Chest/pelvic X-ray in conjunction with ultrasonography have been established classically as initial diagnostic imaging modalities to identify the major sources of internal bleeding including intra-thoracic, intra-abdominal, or retroperitoneal hemorrhage related to pelvic fracture. Massive soft tissue injury, regardless of whether isolated or associated with multiple injuries, occasionally causes extensive hemorrhage and acute traumatic coagulopathy. Specific types of injuries, including soft tissue injury or retroperitoneal hemorrhage unrelated to pelvic fracture, can potentially be overlooked or be considered “occult” causes of bleeding because classical diagnostic imaging often cannot exclude such injuries. The purpose of this narrative review article is to describe “occult” or unusual sources of bleeding associated with blunt trauma. |
| キーワード | soft tissue injury subcutaneous hematoma non-cavitary hemorrhage retroperitoneal hemorrhage hemorrhagic shock |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-10 |
| 巻 | 71巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 363 |
| 終了ページ | 368 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29042693 |
| フルテキストURL | Mod_Rheumatol_26_6_940.pdf fig.pdf tbl.jpg fig_all.zip |
|---|---|
| 著者 | Hara, Chikako| Kubota, Satoshi| Nishida, Takashi| Hiasa, Miki| Hattori, Takako| Aoyama, Eriko| Moriyama, Yoshinori| Kamioka, Hiroshi| Takigawa, Masaharu| |
| キーワード | CCN family Cartilage Megakaryocyte Platelet Regeneration |
| 備考 | This is an Accepted Manuscript of an article published by Taylor & Francis Group| This fulltext availavle in Nov 2017| |
| 発行日 | 2016-11 |
| 出版物タイトル | Modern Rheumatology |
| 巻 | 26巻 |
| 号 | 6号 |
| 出版者 | Taylor & Francis |
| 開始ページ | 940 |
| 終了ページ | 949 |
| ISSN | 1439-7595 |
| NCID | AA1157187X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 26915735 |
| DOI | 10.3109/14397595.2016.1155255 |
| Web of Science KeyUT | 000393121500022 |
| 関連URL | isVersionOf https://doi.org/10.3109/14397595.2016.1155255 |
| フルテキストURL | Adv_Math_305_144.pdf |
|---|---|
| 著者 | Hashimoto, Mitsuyasu| Symondsb, Peter| |
| キーワード | Frobenius direct image Hilbert–Kunz multiplicity F-signature Frobenius limit |
| 備考 | This is an Accepted Manuscript of an article published by Elsevier| |
| 発行日 | 2017-01-10 |
| 出版物タイトル | Advances in Mathematics |
| 巻 | 305巻 |
| 出版者 | Elsevier |
| 開始ページ | 144 |
| 終了ページ | 164 |
| ISSN | 0001-8708 |
| NCID | AA00513055 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| DOI | 10.1016/j.aim.2016.09.020 |
| Web of Science KeyUT | 000406169200003 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.aim.2016.09.020 |
| JaLCDOI | 10.18926/AMO/55305 |
|---|---|
| フルテキストURL | 71_4_291.pdf |
| 著者 | Naganuma, Atsushi| Hoshino, Takashi| Suzuki, Yuhei| Uehara, Daisuke| Kudo, Tomohiro| Ishihara, Hiroshi| Sato, Ken| Kakizaki, Satoru| Yamada, Masanobu| Takagi, Hitoshi| |
| 抄録 | The effect of skeletal muscle mass (SMM) on the outcomes of sorafenib treatment for hepatocellular carcinoma (HCC) has not been established. We measured the SMM in HCC patients treated with sorafenib, evaluated the patients’ survival, and evaluated the association between skeletal muscle depletion and sorafenib treatment. Of the 97 HCC patients treated with sorafenib at our institution in the period from July 2009 to February 2015, our study included 69 patients (51 males, 18 females) who had received sorafenib for ≥ 8 weeks and whose follow-up data were available. SMM was calculated from computed tomography images at the mid-L3 level (cm2) and normalized to height (m2) to yield the L3 skeletal muscle index (L3-SMI, cm2/m2). The median L3-SMI value was higher in the males (43 cm2/m2) compared to the females (36 cm2/m2). In the males only, the multivariate Cox regression identified an L3-SMI <43 cm2/m2 as independently associated with higher mortality compared to an L3-SMI ≥43 cm2/m2 (hazard ratio 2.315, 95% confidence interval: 1.125-4.765, p=0.023). Skeletal muscle depletion is a factor predicting poor prognosis for male patients with advanced HCC treated with sorafenib. |
| キーワード | skeletal muscle depletion hepatocellular carcinoma sorafenib L3 skeletal muscle index prognostic factor |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-08 |
| 巻 | 71巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 291 |
| 終了ページ | 299 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28824184 |
