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Author Oguni, Kohei| Fukushima, Shinnosuke| Hagiya, Hideharu| Kato, Atsushi| Suyama, Atsuhito| Iwata, Takehiro| Miyawaki, Yoshia| Ono, Sawako| Iio, Koji| Otsuka, Fumio|
Keywords Cryptococcosis Fluconazole Glucocorticoids Prostatitis Tocilizumab
Note © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jan. 2026.|
Published Date 2025-01
Publication Title Journal of Infection and Chemotherapy
Volume volume31
Issue issue1
Publisher Elsevier
Start Page 102494
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
File Version author
PubMed ID 39152054
DOI 10.1016/j.jiac.2024.08.009
Web of Science KeyUT 001419817400001
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2024.08.009
JaLCDOI 10.18926/AMO/67873
FullText URL 78_6_465.pdf
Author Ocho, Kazuki| Hagiya, Hideharu| Ishikawa, Hisashi| Otsuka, Fumio|
Abstract An 81-year-old Japanese man with a medical history of diabetes mellitus and hypertension was diagnosed with the novel coronavirus disease 2019 (COVID-19). The patient developed pain in the bilateral shoulders and hips 3 days after the disease onset and presented to our outpatient clinic after 1 month. Referring to diagnostic criteria, we diagnosed him with polymyalgia rheumatica (PMR). We initiated prednisolone at 15 mg per day and his symptoms improved immediately. The clinical course of the patient indicated that the SARS-CoV-2 infection triggered the onset of autoimmune disease, PMR in this case.
Keywords COVID-19 SARS-CoV-2 polymyalgia rheumatica autoimmune diseases human leukocyte antigen
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-12
Volume volume78
Issue issue6
Publisher Okayama University Medical School
Start Page 465
End Page 468
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39719320
Web of Science KeyUT 001397269500002
FullText URL K0007099_abstract_review.pdf K0007099_summary.pdf
Author FUJITA, Koji|
Published Date 2024-09-25
Content Type Thesis or Dissertation
Grant Number 甲第7099号
Granted Date 2024-09-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
JaLCDOI 10.18926/AMO/67664
FullText URL 78_5_401.pdf
Author Toyota, Yusuke| Uda, Kazuhiro| Shirabe, Komei| Moriwake, Tadashi|
Abstract Severe febrile thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease that is endemic in parts of eastern Asia. Few pediatric cases have been reported. We describe a case of SFTS in a seven-year-old girl who presented with prolonged fever and gastrointestinal symptoms. Leukopenia and thrombocytopenia on hematology, and a history of outdoor activity led us to diagnose SFTS, although the patient had no tick bite marks. We also review the literature and discuss the characteristics of pediatric SFTS. Physicians should consider SFTS in the differential diagnosis of fever with thrombocytopenia in children living in endemic areas.
Keywords child tick-borne disease severe febrile thrombocytopenia syndrome zoonoses
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-10
Volume volume78
Issue issue5
Publisher Okayama University Medical School
Start Page 401
End Page 405
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39467658
JaLCDOI 10.18926/AMO/67657
FullText URL 78_5_371.pdf
Author Gotoh, Kazuyoshi| Miyoshi, Makoto| I Putu Bayu Mayura| Tsuji, Shuma| Iio, Koji| Fukushima, Shinnosuke| Matsushita, Osamu| Hagiya, Hideharu|
Abstract Spread of carbapenemase-producing Enterobacterales (CPE) is an ongoing public health issue worldwide, including in Japan. In this study, we investigated the phenotypic and genetic characteristics of CPE isolates at Okayama University Hospital over the 5 years (2013-2018) prior to the outbreak of the 2019 coronavirus pandemic. Of 24 carbapenem-resistant Enterobacterales isolated during the study period, we identified 8 CPE isolates harboring blaIMP-1 (5 isolates) and blaIMP-6 genes (3 isolates). Bacterial species and carbapenem susceptibility patterns exhibited diversity. Minimum inhibitory concentrations (MICs) of meropenem were generally higher than those of imipenem and biapenem. Results of pulsed-field gel electrophoresis demonstrated that neither clonal nor plasmid-mediated outbreaks of blaIMP-harboring CPE isolates have developed at our hospital. One Klebsiella oxytoca isolate showed a high MIC (128 μg/mL) of meropenem, which could be explained by the high plasmid copy number. Subsequent analysis of this isolate may elucidate the intricacies of carbapenem resistance profiles among CPE isolates. Collectively, our findings underscore the necessity for ongoing genetic surveillance of CPE, complemented by tailored approaches for infection prevention and control.
Keywords antimicrobial resistance carbapenemase-producing enterobacterales carbapenemase-resistant enterobacterales Silent pandemic whole genome sequence
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-10
Volume volume78
Issue issue5
Publisher Okayama University Medical School
Start Page 371
End Page 376
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39467655
Web of Science KeyUT 001343346400003
JaLCDOI 10.18926/AMO/67656
FullText URL 78_5_363.pdf
Author Takanaga, Satoe| Matsumoto, Naomi| Kadowaki, Tomoka| Takao, Soshi| Yorifuji, Takashi|
Abstract Kawasaki disease (KD) is a pediatric disease of unknown etiology that commonly affects infants in East Asia. Infants born small for gestational age (SGA) have weaker immune systems and are more susceptible to infection. Using data from a nationwide Japanese birth cohort study conducted in 2010 (n=34,579), we investigated whether SGA increases the risk of KD. SGA was defined as birth weight below the 10th percentile for gestational age. The outcome was hospitalization for KD between 6 and 30 months of age. The association between SGA and hospitalization for KD, adjusted for child and maternal factors, was examined using logistic regression. Of the 231 children hospitalized for KD, 9.5% were SGA. Further statistical analysis showed that SGA did not increase the odds ratio (OR) of hospitalization for KD (adjusted OR 1.12, 95% confidence interval 0.71-1.75). This result was not changed with stratification by early daycare attendance and preterm status. Reasons for the lack of association may include the multifactorial pathogenesis of KD; in addition, the types of infections to which SGA infants are predisposed may differ from those triggering KD. Overall, our large nationwide study found no association between SGA and KD.
Keywords Kawasaki disease (KD) small for gestational age (SGA) cohort epidemiology
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-10
Volume volume78
Issue issue5
Publisher Okayama University Medical School
Start Page 363
End Page 370
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39467654
JaLCDOI 10.18926/AMO/67199
FullText URL 78_3_245.pdf
Author Akagawa, Manabu| Saito, Hidetomo| Takahashi, Yasuhiro| Iwamoto, Yosuke| Iida, Junpei| Yoshikawa, Takayuki| Abe, Toshiki| Saito, Kimio| Kijima, Hiroaki| Kasukawa, Yuji| Hongo, Michio| Miyakoshi, Naohisa|
Abstract Although several studies have suggested a possible association between sarcopenia and knee osteoarthritis (OA) in the elderly, there remains no definitive evidence. Recently, however, the serum creatinine/cystatin C ratio (sarcopenia index: SI) was reported to correlate with skeletal muscle mass. The present retrospective study therefore investigated the impact of reduced skeletal muscle mass on advanced knee OA using SI. In 55 individuals scheduled for knee osteotomy or knee arthroplasty, correlations between SI and patient-reported outcomes such as the Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS) were explored. Significant associations were found between SI and the KSS functional activity score (β=0.37; p=0.022), KOOS subscale for activities of daily living (β=0.42; p=0.0096), and OKS (β=0.42; p=0.0095). This study underscores the role of reduced muscle mass in functional outcomes and introduces SI as a valuable marker for assessing muscle loss in knee OA patients.
Keywords knee osteoarthritis sarcopenia index reduced muscle mass activities of daily living functional activity
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 245
End Page 250
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902212
Web of Science KeyUT 001267351000005
JaLCDOI 10.18926/AMO/67195
FullText URL 78_3_205.pdf
Author Hagiya, Hideharu|
Abstract The global pandemic of COVID-19 has underscored the significance of establishing and sustaining a practical and efficient infection control system for the benefit and welfare of society. Infectious disease (ID) specialists are expected to take on leadership roles in enhancing organizational infrastructures for infection prevention and control (IPC) at the hospital, community, and national levels. However, due to an absolute shortage and an uneven distribution, many core hospitals currently lack the ID specialists. Given the escalating global risk of emerging and re-emerging infectious diseases as well as antimicrobial resistance pathogens, the education and training of ID specialists constitutes an imperative concern. As demonstrated by historical changes in the healthcare reimbursement system, the establishment and enhancement of IPC measures is pivotal to ensuring medical safety. The existing structure of academic society-driven certification and training initiatives for ID specialists, contingent upon the discretionary decisions of individual physicians, possesses both quantitative and qualitative shortcomings. In this article, I first address the present situations and challenges related to ID specialists and then introduce my idea of securing ID specialists based on the new concepts and platforms; (i) ID Specialists as National Credentials, (ii) Establishment of the Department of Infectious Diseases in Medical and Graduate Schools, (iii) Endowed ID Educative Courses Funded by Local Government and Pharmaceutical Companies, and (iv) Recruitment of Young Physicians Engaged in Healthcare Services in Remote Areas. As clarified by the COVID-19 pandemic, ID specialists play a crucial role in safeguarding public health. Hopefully, this article will advance the discussion and organizational reform for the education and training of ID specialists.
Keywords antimicrobial resistance emerging infectious diseases infection prevention and control medical education silent pandemic
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 205
End Page 213
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902208
Web of Science KeyUT 001267351000001
JaLCDOI 10.18926/AMO/66928
FullText URL 78_2_193.pdf
Author Kashima, Hajime| Teraishi, Fuminori| Matsumi, Yuki| Shimamura, Hiroshi| Fujiwara, Toshiyoshi|
Abstract Tailgut cyst is a rare cystic disease of the anterior sacral surface and the remains of an embryonic tail gut. Tailgut cysts have a potential for malignancy, and complete resection with an adequate surgical margin is necessary. Even if incomplete resection does not result in recurrence of malignant disease, there is a risk of local infection leading to refractory fistulas. The optimal treatment for such refractory recurrent lesions has not been reported. We describe a case in which the combination of laparoscopic and transsacral approaches was effective for resecting a recurrent refractory fistula after incomplete resection of a tail gut cyst.
Keywords tailgut cyst laparoscopic resection fistula formation
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 193
End Page 196
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688837
Web of Science KeyUT 001227932200003
JaLCDOI 10.18926/AMO/66927
FullText URL 78_2_185.pdf
Author Takahashi, Hiroko| Eguchi, Jun| Watanabe, Mayu| Nakayama, Masanori| Wada, Jun|
Abstract The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients.
Keywords obesity type 2 diabetes COVID-19 vaccination
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 185
End Page 191
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688836
Web of Science KeyUT 001227932200002
JaLCDOI 10.18926/AMO/66913
FullText URL 78_2_107.pdf
Author Han, Dongxiang| Du, Jianxiu| Wang, Wei| Wang, Cui|
Abstract Vertical transmission of hepatitis B virus (HBV), especially in Asia, is a key target in the global elimination of HBV. This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. There were no significant differences in liver function markers, including alanine aminotransferase, total bilirubin, blood creatinine, and blood urea nitrogen levels before and after TDF treatment. The serum HBV DNA viral load of the TDF-treated group became significantly lower than those of the control group and their own pre-medication levels. Infants showed no significant difference in body growth, including weight, height, head size, and five-min Apgar score. At 7 months after birth, 94.29% of infants in the TDF group and 86.54% of control-group infants had protective HBsAb levels ≥ 10 mIU/ml (p>0.05). The HBV infection rate of infants in the TDF-treated group was lower than that in the non-treated group. In high-HBV-DNA-load pregnant women, TDF administered from 28 weeks gestational age to delivery was associated with a lower risk of mother-to-infant transmission of HBV.
Keywords mother-to-infant transmission tenofovir disoproxil fumarate hepatitis B virus
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 107
End Page 113
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688828
Web of Science KeyUT 001229151800002
JaLCDOI 10.18926/AMO/66912
FullText URL 78_2_095.pdf
Author Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki|
Abstract The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases.
Keywords neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 95
End Page 106
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688827
Web of Science KeyUT 001229151800001
FullText URL fulltext.pdf
Author Yasutake, Nobuko| Yamamoto, Hidetaka| Kuga, Ryosuke| Jiromaru, Rina| Hongo, Takahiro| Katayama, Yoshihiro| Sonoda, Kenzo| Yahata, Hideaki| Kato, Kiyoko| Oda, Yoshinao|
Keywords endocervical adenocarcinoma human papillomavirus p16 Rb uterus
Published Date 2024-03-06
Publication Title Histopathology
Volume volume84
Issue issue7
Publisher Wiley
Start Page 1178
End Page 1191
ISSN 0309-0167
NCID AA00664436
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Authors.
File Version publisher
PubMed ID 38445509
DOI 10.1111/his.15169
Web of Science KeyUT 001179165100001
Related Url isVersionOf https://doi.org/10.1111/his.15169
FullText URL fulltext.pdf
Author Fukushima, Shinnosuke| Hagiya, Hideharu| Honda, Hiroyuki| Ishida, Tomoharu| Shoji, Ryohei| Hasegawa, Kou| Otsuka, Fumio|
Keywords Bacteremia Calcium polystyrene sulfonate Escherichia coli Infective endocarditis Rectal ulcer
Note The version of record of this article, first published in Clinical Journal of Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12328-024-01949-4|
Published Date 2024-03-25
Publication Title Clinical Journal of Gastroenterology
Volume volume17
Issue issue3
Publisher Springer Science and Business Media LLC
Start Page 472
End Page 476
ISSN 1865-7257
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38528197
DOI 10.1007/s12328-024-01949-4
Web of Science KeyUT 001190477300001
Related Url isVersionOf https://doi.org/10.1007/s12328-024-01949-4
FullText URL fulltext20240322-01.pdf
Author Matsuo, Toshihiko| Matsuo, Chie Nakago| Matsuo, Nobuhiko| Mori, Ayano| Murakami, Masaaki| Ito, Hiroshi|
Keywords pericardial effusion pericarditis periodontitis (periodontal disease) positron emission tomography Streptococcus
Published Date 2024-03-19
Publication Title Journal of Investigative Medicine High Impact Case Reports
Volume volume12
Publisher SAGE Publications
ISSN 2324-7096
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 American Federation for Medical Research.
File Version publisher
PubMed ID 38504421
DOI 10.1177/23247096241239559
Web of Science KeyUT 001188152000001
Related Url isVersionOf https://doi.org/10.1177/23247096241239559
FullText URL fulltext.pdf
Author Mitoma, Tomohiro| Maki, Jota| Ooba, Hikaru| Ogawa, Chikako| Masuyama, Hisashi| Tabuchi, Takahiro|
Keywords cervical cancer screening social inequality screening hesitation internet survey
Published Date 2024-02-13
Publication Title International Journal of General Medicine
Volume volume17
Publisher Dove Press
Start Page 541
End Page 551
ISSN 1178-7074
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Mitoma et al.
File Version publisher
PubMed ID 38371520
DOI 10.2147/IJGM.S453675
Web of Science KeyUT 001162765400001
Related Url isVersionOf https://doi.org/10.2147/IJGM.S453675
FullText URL fulltext.pdf
Author Kobayashi, Hiroki| Ouchi, Tomoki| Kitamura, Wataru| Asakura, Shoji| Yano, Tomofumi| Takeda, Hiromasa| Tokuda, Yoshiyuki| Yoshino, Tadashi| Maeda, Yoshinobu|
Keywords cold agglutinin disease severe acute respiratory syndrome coronavirus 2 sutimlimab
Published Date 2023-12-26
Publication Title Journal of Clinical and Experimental Hematopathology
Volume volume63
Issue issue4
Publisher The Japanese Society for Lymphoreticular Tissue Research
Start Page 246
End Page 250
ISSN 1346-4280
NCID AA11556796
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Japanese Society for Lymphoreticular Tissue Research
File Version publisher
PubMed ID 38148014
DOI 10.3960/jslrt.23040
Web of Science KeyUT 001134578000003
Related Url isVersionOf https://doi.org/10.3960/jslrt.23040
JaLCDOI 10.18926/AMO/66151
FullText URL 77_6_595.pdf
Author Bando, Takashi| Chuma, Masayuki| Hamano, Hirofumi| Niimura, Takahiro| Okada, Naoto| Kondo, Masateru| Izumi, Yuki| Ishida, Shunsuke| Yoshioka, Toshihiko| Asada, Mizuho| Zamami, Yoshito| Takechi, Kenshi| Goda, Mitsuhiro| Miyata, Koji| Yagi, Kenta| Izawa-Ishizawa, Yuki| Azuma, Momoyo| Yanagawa, Hiroaki| Tasaki, Yoshikazu| Ishizawa, Keisuke|
Abstract There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51-1.85]; VCM + ≥2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37-1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42-2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN.
Keywords vancomycin-associated nephrotoxicity polypharmacy nephrotoxin spontaneous adverse event reporting database electronic medical records
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-12
Volume volume77
Issue issue6
Publisher Okayama University Medical School
Start Page 595
End Page 605
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38145933
Web of Science KeyUT 001164631200004
FullText URL fulltext20231205-01.pdf fig20231205-01.pdf suppl20231205-01.pdf
Author Matsumoto, Naomi| Shimizu, Junya| Yokoyama, Yuji| Tsukahara, Hirokazu| Yorifuji, Takashi|
Keywords adverse reaction BNT162b2 COVID-19 vaccine young children
Note This is the peer reviewed version of the following article: [Matsumoto, N, Shimizu, J, Yokoyama, Y, Tsukahara, H, Yorifuji, T. Adverse reactions in young children receiving the coronavirus disease 2019 vaccine. Pediatr Int. 2023; 65:e15696. https://doi.org/10.1111/ped.15696], which has been published in final form at [https://doi.org/10.1111/ped.15696]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Nov. 2024.|
Published Date 2023-11-15
Publication Title Pediatrics International
Volume volume65
Issue issue1
Publisher Wiley
Start Page e15696
ISSN 1328-8067
NCID AA11320483
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Japan Pediatric Society.
File Version author
PubMed ID 37968891
DOI 10.1111/ped.15696
Web of Science KeyUT 001105283700001
Related Url isVersionOf https://doi.org/10.1111/ped.15696
FullText URL fulltext.pdf
Author Nishihata, Yu| Liu, Ziang| Nishi, Tatsushi|
Keywords inventory management SEIR model evolutionary game theory
Published Date 2023-10-14
Publication Title Applied Sciences
Volume volume13
Issue issue20
Publisher MDPI
Start Page 11308
ISSN 2076-3417
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
DOI 10.3390/app132011308
Web of Science KeyUT 001090619000001
Related Url isVersionOf https://doi.org/10.3390/app132011308