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著者 Oguni, Kohei| Fukushima, Shinnosuke| Hagiya, Hideharu| Kato, Atsushi| Suyama, Atsuhito| Iwata, Takehiro| Miyawaki, Yoshia| Ono, Sawako| Iio, Koji| Otsuka, Fumio|
キーワード Cryptococcosis Fluconazole Glucocorticoids Prostatitis Tocilizumab
備考 © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jan. 2026.|
発行日 2025-01
出版物タイトル Journal of Infection and Chemotherapy
31巻
1号
出版者 Elsevier
開始ページ 102494
ISSN 1341-321X
NCID AA11057978
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
論文のバージョン author
PubMed ID 39152054
DOI 10.1016/j.jiac.2024.08.009
Web of Science KeyUT 001419817400001
関連URL isVersionOf https://doi.org/10.1016/j.jiac.2024.08.009
JaLCDOI 10.18926/AMO/67873
フルテキストURL 78_6_465.pdf
著者 Ocho, Kazuki| Hagiya, Hideharu| Ishikawa, Hisashi| Otsuka, Fumio|
抄録 An 81-year-old Japanese man with a medical history of diabetes mellitus and hypertension was diagnosed with the novel coronavirus disease 2019 (COVID-19). The patient developed pain in the bilateral shoulders and hips 3 days after the disease onset and presented to our outpatient clinic after 1 month. Referring to diagnostic criteria, we diagnosed him with polymyalgia rheumatica (PMR). We initiated prednisolone at 15 mg per day and his symptoms improved immediately. The clinical course of the patient indicated that the SARS-CoV-2 infection triggered the onset of autoimmune disease, PMR in this case.
キーワード COVID-19 SARS-CoV-2 polymyalgia rheumatica autoimmune diseases human leukocyte antigen
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2024-12
78巻
6号
出版者 Okayama University Medical School
開始ページ 465
終了ページ 468
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 39719320
Web of Science KeyUT 001397269500002
フルテキストURL K0007099_abstract_review.pdf K0007099_summary.pdf
著者 藤田 浩二|
発行日 2024-09-25
資料タイプ 学位論文
学位授与番号 甲第7099号
学位授与年月日 2024-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著作権者 © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
JaLCDOI 10.18926/AMO/67664
フルテキストURL 78_5_401.pdf
著者 Toyota, Yusuke| Uda, Kazuhiro| Shirabe, Komei| Moriwake, Tadashi|
抄録 Severe febrile thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease that is endemic in parts of eastern Asia. Few pediatric cases have been reported. We describe a case of SFTS in a seven-year-old girl who presented with prolonged fever and gastrointestinal symptoms. Leukopenia and thrombocytopenia on hematology, and a history of outdoor activity led us to diagnose SFTS, although the patient had no tick bite marks. We also review the literature and discuss the characteristics of pediatric SFTS. Physicians should consider SFTS in the differential diagnosis of fever with thrombocytopenia in children living in endemic areas.
キーワード child tick-borne disease severe febrile thrombocytopenia syndrome zoonoses
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2024-10
78巻
5号
出版者 Okayama University Medical School
開始ページ 401
終了ページ 405
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 39467658
JaLCDOI 10.18926/AMO/67657
フルテキストURL 78_5_371.pdf
著者 Gotoh, Kazuyoshi| Miyoshi, Makoto| I Putu Bayu Mayura| Tsuji, Shuma| Iio, Koji| Fukushima, Shinnosuke| Matsushita, Osamu| Hagiya, Hideharu|
抄録 Spread of carbapenemase-producing Enterobacterales (CPE) is an ongoing public health issue worldwide, including in Japan. In this study, we investigated the phenotypic and genetic characteristics of CPE isolates at Okayama University Hospital over the 5 years (2013-2018) prior to the outbreak of the 2019 coronavirus pandemic. Of 24 carbapenem-resistant Enterobacterales isolated during the study period, we identified 8 CPE isolates harboring blaIMP-1 (5 isolates) and blaIMP-6 genes (3 isolates). Bacterial species and carbapenem susceptibility patterns exhibited diversity. Minimum inhibitory concentrations (MICs) of meropenem were generally higher than those of imipenem and biapenem. Results of pulsed-field gel electrophoresis demonstrated that neither clonal nor plasmid-mediated outbreaks of blaIMP-harboring CPE isolates have developed at our hospital. One Klebsiella oxytoca isolate showed a high MIC (128 μg/mL) of meropenem, which could be explained by the high plasmid copy number. Subsequent analysis of this isolate may elucidate the intricacies of carbapenem resistance profiles among CPE isolates. Collectively, our findings underscore the necessity for ongoing genetic surveillance of CPE, complemented by tailored approaches for infection prevention and control.
キーワード antimicrobial resistance carbapenemase-producing enterobacterales carbapenemase-resistant enterobacterales Silent pandemic whole genome sequence
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-10
78巻
5号
出版者 Okayama University Medical School
開始ページ 371
終了ページ 376
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 39467655
Web of Science KeyUT 001343346400003
JaLCDOI 10.18926/AMO/67656
フルテキストURL 78_5_363.pdf
著者 Takanaga, Satoe| Matsumoto, Naomi| Kadowaki, Tomoka| Takao, Soshi| Yorifuji, Takashi|
抄録 Kawasaki disease (KD) is a pediatric disease of unknown etiology that commonly affects infants in East Asia. Infants born small for gestational age (SGA) have weaker immune systems and are more susceptible to infection. Using data from a nationwide Japanese birth cohort study conducted in 2010 (n=34,579), we investigated whether SGA increases the risk of KD. SGA was defined as birth weight below the 10th percentile for gestational age. The outcome was hospitalization for KD between 6 and 30 months of age. The association between SGA and hospitalization for KD, adjusted for child and maternal factors, was examined using logistic regression. Of the 231 children hospitalized for KD, 9.5% were SGA. Further statistical analysis showed that SGA did not increase the odds ratio (OR) of hospitalization for KD (adjusted OR 1.12, 95% confidence interval 0.71-1.75). This result was not changed with stratification by early daycare attendance and preterm status. Reasons for the lack of association may include the multifactorial pathogenesis of KD; in addition, the types of infections to which SGA infants are predisposed may differ from those triggering KD. Overall, our large nationwide study found no association between SGA and KD.
キーワード Kawasaki disease (KD) small for gestational age (SGA) cohort epidemiology
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-10
78巻
5号
出版者 Okayama University Medical School
開始ページ 363
終了ページ 370
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 39467654
JaLCDOI 10.18926/AMO/67199
フルテキストURL 78_3_245.pdf
著者 Akagawa, Manabu| Saito, Hidetomo| Takahashi, Yasuhiro| Iwamoto, Yosuke| Iida, Junpei| Yoshikawa, Takayuki| Abe, Toshiki| Saito, Kimio| Kijima, Hiroaki| Kasukawa, Yuji| Hongo, Michio| Miyakoshi, Naohisa|
抄録 Although several studies have suggested a possible association between sarcopenia and knee osteoarthritis (OA) in the elderly, there remains no definitive evidence. Recently, however, the serum creatinine/cystatin C ratio (sarcopenia index: SI) was reported to correlate with skeletal muscle mass. The present retrospective study therefore investigated the impact of reduced skeletal muscle mass on advanced knee OA using SI. In 55 individuals scheduled for knee osteotomy or knee arthroplasty, correlations between SI and patient-reported outcomes such as the Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS) were explored. Significant associations were found between SI and the KSS functional activity score (β=0.37; p=0.022), KOOS subscale for activities of daily living (β=0.42; p=0.0096), and OKS (β=0.42; p=0.0095). This study underscores the role of reduced muscle mass in functional outcomes and introduces SI as a valuable marker for assessing muscle loss in knee OA patients.
キーワード knee osteoarthritis sarcopenia index reduced muscle mass activities of daily living functional activity
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-06
78巻
3号
出版者 Okayama University Medical School
開始ページ 245
終了ページ 250
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38902212
Web of Science KeyUT 001267351000005
JaLCDOI 10.18926/AMO/67195
フルテキストURL 78_3_205.pdf
著者 Hagiya, Hideharu|
抄録 The global pandemic of COVID-19 has underscored the significance of establishing and sustaining a practical and efficient infection control system for the benefit and welfare of society. Infectious disease (ID) specialists are expected to take on leadership roles in enhancing organizational infrastructures for infection prevention and control (IPC) at the hospital, community, and national levels. However, due to an absolute shortage and an uneven distribution, many core hospitals currently lack the ID specialists. Given the escalating global risk of emerging and re-emerging infectious diseases as well as antimicrobial resistance pathogens, the education and training of ID specialists constitutes an imperative concern. As demonstrated by historical changes in the healthcare reimbursement system, the establishment and enhancement of IPC measures is pivotal to ensuring medical safety. The existing structure of academic society-driven certification and training initiatives for ID specialists, contingent upon the discretionary decisions of individual physicians, possesses both quantitative and qualitative shortcomings. In this article, I first address the present situations and challenges related to ID specialists and then introduce my idea of securing ID specialists based on the new concepts and platforms; (i) ID Specialists as National Credentials, (ii) Establishment of the Department of Infectious Diseases in Medical and Graduate Schools, (iii) Endowed ID Educative Courses Funded by Local Government and Pharmaceutical Companies, and (iv) Recruitment of Young Physicians Engaged in Healthcare Services in Remote Areas. As clarified by the COVID-19 pandemic, ID specialists play a crucial role in safeguarding public health. Hopefully, this article will advance the discussion and organizational reform for the education and training of ID specialists.
キーワード antimicrobial resistance emerging infectious diseases infection prevention and control medical education silent pandemic
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2024-06
78巻
3号
出版者 Okayama University Medical School
開始ページ 205
終了ページ 213
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38902208
Web of Science KeyUT 001267351000001
JaLCDOI 10.18926/AMO/66928
フルテキストURL 78_2_193.pdf
著者 Kashima, Hajime| Teraishi, Fuminori| Matsumi, Yuki| Shimamura, Hiroshi| Fujiwara, Toshiyoshi|
抄録 Tailgut cyst is a rare cystic disease of the anterior sacral surface and the remains of an embryonic tail gut. Tailgut cysts have a potential for malignancy, and complete resection with an adequate surgical margin is necessary. Even if incomplete resection does not result in recurrence of malignant disease, there is a risk of local infection leading to refractory fistulas. The optimal treatment for such refractory recurrent lesions has not been reported. We describe a case in which the combination of laparoscopic and transsacral approaches was effective for resecting a recurrent refractory fistula after incomplete resection of a tail gut cyst.
キーワード tailgut cyst laparoscopic resection fistula formation
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2024-04
78巻
2号
出版者 Okayama University Medical School
開始ページ 193
終了ページ 196
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38688837
Web of Science KeyUT 001227932200003
JaLCDOI 10.18926/AMO/66927
フルテキストURL 78_2_185.pdf
著者 Takahashi, Hiroko| Eguchi, Jun| Watanabe, Mayu| Nakayama, Masanori| Wada, Jun|
抄録 The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients.
キーワード obesity type 2 diabetes COVID-19 vaccination
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-04
78巻
2号
出版者 Okayama University Medical School
開始ページ 185
終了ページ 191
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38688836
Web of Science KeyUT 001227932200002
JaLCDOI 10.18926/AMO/66913
フルテキストURL 78_2_107.pdf
著者 Han, Dongxiang| Du, Jianxiu| Wang, Wei| Wang, Cui|
抄録 Vertical transmission of hepatitis B virus (HBV), especially in Asia, is a key target in the global elimination of HBV. This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. There were no significant differences in liver function markers, including alanine aminotransferase, total bilirubin, blood creatinine, and blood urea nitrogen levels before and after TDF treatment. The serum HBV DNA viral load of the TDF-treated group became significantly lower than those of the control group and their own pre-medication levels. Infants showed no significant difference in body growth, including weight, height, head size, and five-min Apgar score. At 7 months after birth, 94.29% of infants in the TDF group and 86.54% of control-group infants had protective HBsAb levels ≥ 10 mIU/ml (p>0.05). The HBV infection rate of infants in the TDF-treated group was lower than that in the non-treated group. In high-HBV-DNA-load pregnant women, TDF administered from 28 weeks gestational age to delivery was associated with a lower risk of mother-to-infant transmission of HBV.
キーワード mother-to-infant transmission tenofovir disoproxil fumarate hepatitis B virus
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2024-04
78巻
2号
出版者 Okayama University Medical School
開始ページ 107
終了ページ 113
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38688828
Web of Science KeyUT 001229151800002
JaLCDOI 10.18926/AMO/66912
フルテキストURL 78_2_095.pdf
著者 Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki|
抄録 The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases.
キーワード neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2024-04
78巻
2号
出版者 Okayama University Medical School
開始ページ 95
終了ページ 106
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38688827
Web of Science KeyUT 001229151800001
フルテキストURL fulltext.pdf
著者 Yasutake, Nobuko| Yamamoto, Hidetaka| Kuga, Ryosuke| Jiromaru, Rina| Hongo, Takahiro| Katayama, Yoshihiro| Sonoda, Kenzo| Yahata, Hideaki| Kato, Kiyoko| Oda, Yoshinao|
キーワード endocervical adenocarcinoma human papillomavirus p16 Rb uterus
発行日 2024-03-06
出版物タイトル Histopathology
84巻
7号
出版者 Wiley
開始ページ 1178
終了ページ 1191
ISSN 0309-0167
NCID AA00664436
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 The Authors.
論文のバージョン publisher
PubMed ID 38445509
DOI 10.1111/his.15169
Web of Science KeyUT 001179165100001
関連URL isVersionOf https://doi.org/10.1111/his.15169
フルテキストURL fulltext.pdf
著者 Fukushima, Shinnosuke| Hagiya, Hideharu| Honda, Hiroyuki| Ishida, Tomoharu| Shoji, Ryohei| Hasegawa, Kou| Otsuka, Fumio|
キーワード Bacteremia Calcium polystyrene sulfonate Escherichia coli Infective endocarditis Rectal ulcer
備考 The version of record of this article, first published in Clinical Journal of Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12328-024-01949-4|
発行日 2024-03-25
出版物タイトル Clinical Journal of Gastroenterology
17巻
3号
出版者 Springer Science and Business Media LLC
開始ページ 472
終了ページ 476
ISSN 1865-7257
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2024
論文のバージョン publisher
PubMed ID 38528197
DOI 10.1007/s12328-024-01949-4
Web of Science KeyUT 001190477300001
関連URL isVersionOf https://doi.org/10.1007/s12328-024-01949-4
フルテキストURL fulltext20240322-01.pdf
著者 Matsuo, Toshihiko| Matsuo, Chie Nakago| Matsuo, Nobuhiko| Mori, Ayano| Murakami, Masaaki| Ito, Hiroshi|
キーワード pericardial effusion pericarditis periodontitis (periodontal disease) positron emission tomography Streptococcus
発行日 2024-03-19
出版物タイトル Journal of Investigative Medicine High Impact Case Reports
12巻
出版者 SAGE Publications
ISSN 2324-7096
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 American Federation for Medical Research.
論文のバージョン publisher
PubMed ID 38504421
DOI 10.1177/23247096241239559
Web of Science KeyUT 001188152000001
関連URL isVersionOf https://doi.org/10.1177/23247096241239559
フルテキストURL fulltext.pdf
著者 Mitoma, Tomohiro| Maki, Jota| Ooba, Hikaru| Ogawa, Chikako| Masuyama, Hisashi| Tabuchi, Takahiro|
キーワード cervical cancer screening social inequality screening hesitation internet survey
発行日 2024-02-13
出版物タイトル International Journal of General Medicine
17巻
出版者 Dove Press
開始ページ 541
終了ページ 551
ISSN 1178-7074
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2024 Mitoma et al.
論文のバージョン publisher
PubMed ID 38371520
DOI 10.2147/IJGM.S453675
Web of Science KeyUT 001162765400001
関連URL isVersionOf https://doi.org/10.2147/IJGM.S453675
フルテキストURL fulltext.pdf
著者 Kobayashi, Hiroki| Ouchi, Tomoki| Kitamura, Wataru| Asakura, Shoji| Yano, Tomofumi| Takeda, Hiromasa| Tokuda, Yoshiyuki| Yoshino, Tadashi| Maeda, Yoshinobu|
キーワード cold agglutinin disease severe acute respiratory syndrome coronavirus 2 sutimlimab
発行日 2023-12-26
出版物タイトル Journal of Clinical and Experimental Hematopathology
63巻
4号
出版者 The Japanese Society for Lymphoreticular Tissue Research
開始ページ 246
終了ページ 250
ISSN 1346-4280
NCID AA11556796
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン publisher
PubMed ID 38148014
DOI 10.3960/jslrt.23040
Web of Science KeyUT 001134578000003
関連URL isVersionOf https://doi.org/10.3960/jslrt.23040
JaLCDOI 10.18926/AMO/66151
フルテキストURL 77_6_595.pdf
著者 Bando, Takashi| Chuma, Masayuki| Hamano, Hirofumi| Niimura, Takahiro| Okada, Naoto| Kondo, Masateru| Izumi, Yuki| Ishida, Shunsuke| Yoshioka, Toshihiko| Asada, Mizuho| Zamami, Yoshito| Takechi, Kenshi| Goda, Mitsuhiro| Miyata, Koji| Yagi, Kenta| Izawa-Ishizawa, Yuki| Azuma, Momoyo| Yanagawa, Hiroaki| Tasaki, Yoshikazu| Ishizawa, Keisuke|
抄録 There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51-1.85]; VCM + ≥2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37-1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42-2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN.
キーワード vancomycin-associated nephrotoxicity polypharmacy nephrotoxin spontaneous adverse event reporting database electronic medical records
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-12
77巻
6号
出版者 Okayama University Medical School
開始ページ 595
終了ページ 605
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 38145933
Web of Science KeyUT 001164631200004
フルテキストURL fulltext20231205-01.pdf fig20231205-01.pdf suppl20231205-01.pdf
著者 Matsumoto, Naomi| Shimizu, Junya| Yokoyama, Yuji| Tsukahara, Hirokazu| Yorifuji, Takashi|
キーワード adverse reaction BNT162b2 COVID-19 vaccine young children
備考 This is the peer reviewed version of the following article: [Matsumoto, N, Shimizu, J, Yokoyama, Y, Tsukahara, H, Yorifuji, T. Adverse reactions in young children receiving the coronavirus disease 2019 vaccine. Pediatr Int. 2023; 65:e15696. https://doi.org/10.1111/ped.15696], which has been published in final form at [https://doi.org/10.1111/ped.15696]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Nov. 2024.|
発行日 2023-11-15
出版物タイトル Pediatrics International
65巻
1号
出版者 Wiley
開始ページ e15696
ISSN 1328-8067
NCID AA11320483
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 Japan Pediatric Society.
論文のバージョン author
PubMed ID 37968891
DOI 10.1111/ped.15696
Web of Science KeyUT 001105283700001
関連URL isVersionOf https://doi.org/10.1111/ped.15696
フルテキストURL fulltext.pdf
著者 Nishihata, Yu| Liu, Ziang| Nishi, Tatsushi|
キーワード inventory management SEIR model evolutionary game theory
発行日 2023-10-14
出版物タイトル Applied Sciences
13巻
20号
出版者 MDPI
開始ページ 11308
ISSN 2076-3417
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 by the authors.
論文のバージョン publisher
DOI 10.3390/app132011308
Web of Science KeyUT 001090619000001
関連URL isVersionOf https://doi.org/10.3390/app132011308