検索結果 127 件
| フルテキストURL | fulltext20220830-1.pdf |
|---|---|
| 著者 | Hagiya, Hideharu| Takase, Ryosuke| Sazumi, Yosuke| Nishimura, Yoshito| Honda, Hiroyuki| Otsuka, Fumio| |
| 備考 | This is an Accepted Manuscript of an article published by SAGE Publications.| |
| 発行日 | 2022-05-05 |
| 出版物タイトル | Journal of Infection Prevention |
| 巻 | 23巻 |
| 号 | 5号 |
| 出版者 | SAGE Publications |
| 開始ページ | 239 |
| 終了ページ | 242 |
| ISSN | 1757-1774 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | Copyright © 2022 by Infection Prevention Society |
| 論文のバージョン | author |
| PubMed ID | 36003134 |
| DOI | 10.1177/17571774221094160 |
| Web of Science KeyUT | 000843414400007 |
| 関連URL | isVersionOf https://doi.org/10.1177/17571774221094160 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Uda, Kazuhiro| Hagiya, Hideharu| Yorifuji, Takashi| Koyama, Toshihiro| Tsuge, Mitsuru| Yashiro, Masato| Tsukahara, Hirokazu| |
| キーワード | RSV Surveillance Google Trends Epidemiology |
| 発行日 | 2022-08-09 |
| 出版物タイトル | BMC Public Health |
| 巻 | 22巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 1517 |
| ISSN | 1471-2458 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 35945532 |
| DOI | 10.1186/s12889-022-13899-y |
| Web of Science KeyUT | 000838077700004 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12889-022-13899-y |
| フルテキストURL | K0006542_abstract_review.pdf K0006542_fulltext.pdf K0006542_summary.pdf |
|---|---|
| 著者 | 吉永 香澄| |
| 発行日 | 2022-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6542号 |
| 学位授与年月日 | 2022-03-25 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2020 The Japanese Urological Association |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Muzembo, Basilua Andre| Ntontolo, Ngangu Patrick| Ngatu, Nlandu Roger| Khatiwada, Januka| Suzuki, Tomoko| Wada, Koji| Kitahara, Kei| Ikeda, Shunya| Miyoshi, Shin-Ichi| |
| キーワード | Ebola knowledge attitudes practices beliefs misperceptions rumors sub-Saharan Africa |
| 発行日 | 2022-04-13 |
| 出版物タイトル | International Journal Of Environmental Research and Public Health |
| 巻 | 19巻 |
| 号 | 8号 |
| 出版者 | MDPI |
| 開始ページ | 4714 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35457585 |
| DOI | 10.3390/ijerph19084714 |
| Web of Science KeyUT | 000785094500001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph19084714 |
| フルテキストURL | fulltext20220413-1.pdf figures20220413-1.pdf tables20220413-1.pdf FeaturedImage20220413-1.pdf SI20220413-1.pdf |
|---|---|
| 著者 | Fukushima, Shinnosuke| Hagiya, Hideharu| Fujita, Koji| Kamiyama, Shinya| Yamada, Haruto| Kishida, Masayuki| Otsuka, Fumio| |
| キーワード | bloodstream infection infectious focus intra-abdominal infection polymicrobial bacteremia prognosis risk factors |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s15010-022-01799-7| |
| 発行日 | 2022-3-17 |
| 出版物タイトル | Infection |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 0300-8126 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022 |
| 論文のバージョン | author |
| PubMed ID | 35301683 |
| DOI | 10.1007/s15010-022-01799-7 |
| Web of Science KeyUT | 000770187300002 |
| 関連URL | isVersionOf https://doi.org/10.1007/s15010-022-01799-7 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tsumura, Munechika| Makihara, Seiichiro| Nishikori, Asami| Gion, Yuka| Morito, Toshiaki| Miyamoto, Shotaro| Naito, Tomoyuki| Uraguchi, Kensuke| Oka, Aiko| Tachibana, Tomoyasu| Orita, Yorihisa| Kariya, Shin| Okano, Mitsuhiro| Ando, Mizuo| Sato, Yasuharu| |
| キーワード | HPV infection sinonasal inverted papilloma diabetes mellitus young adult tumor stage |
| 発行日 | 2022-02-10 |
| 出版物タイトル | Diagnostics |
| 巻 | 12巻 |
| 号 | 2号 |
| 出版者 | MDPI |
| 開始ページ | 454 |
| ISSN | 2075-4418 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35204545 |
| DOI | 10.3390/diagnostics12020454 |
| Web of Science KeyUT | 000767759900001 |
| 関連URL | isVersionOf https://doi.org/10.3390/diagnostics12020454 |
| JaLCDOI | 10.18926/AMO/63214 |
|---|---|
| フルテキストURL | 76_1_71.pdf |
| 著者 | Tanaka, Masato| Sonawane, Sumeet| Fujiwara, Yoshihiro| Uotani, Koji| Arataki, Shinya| Yamauchi, Taro| Ye, Youchen| Misawa, Haruo| |
| 抄録 | The surgical treatment of pediatric atlantoaxial subluxation (AAS) in Down syndrome (DS) remains technically challenging due to radiation exposure and complications such as vertebral artery injury and nonunion. The established treatment is fixation with a C1 lateral mass screw and C2 pedicle screw (modified Goel technique). However, this technique requires fluoroscopy for C1 screw insertion. To avoid exposing the operating team to radiation we present here a new C-arm free O-arm navigated surgical procedure for pediatric AAS in DS. A 5-year-old male DS patient had neck pain and unsteady gait. Radiograms showed AAS with an atlantodental interval of 10 mm, and irreducible subluxation on extension. CT scan showed Os odontoideum and AAS. MRI demonstrated spinal cord compression between the C1 posterior arch and odontoid process. We performed a C-arm free O-arm navigated modified Goel procedure with postoperative halo-vest immobilization. At oneyear follow-up, good neurological recovery and solid bone fusion were observed. The patient had no complications such as epidural hematoma, infection, or nerve or vessel injury. This novel procedure is a useful and safe technique that protects surgeons and staff from radiation risk. |
| キーワード | atlantoaxial fixation Down syndrome C-arm free O-arm navigation surgery modified Goel technique |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 71 |
| 終了ページ | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237001 |
| Web of Science KeyUT | 000762803800001 |
| JaLCDOI | 10.18926/AMO/63213 |
|---|---|
| フルテキストURL | 76_1_63.pdf |
| 著者 | Zhang, Bei| Pei, Zhixin| Wang, Hongxia| Wu, Huimin| Wang, Junjie| Bai, Junjun| Song, Qinglin| |
| 抄録 | We analyzed the treatment effects of chidamide and decitabine in combination with a HAG (homoharringtonine, cytarabine, G-CSF) priming regimen (CDHAG) in acute myeloid leukemia (AML) patients with TP53 mutation. Seven TP53 mutated AML patients were treated with CDHAG. The treatment effects were assessed using hemogram detection and bone marrow aspirate. The possible side effects were evaluated based on both hematological and non-hematological toxicity. Four of the seven patients were classified as having achieved complete remission after CDHAG treatment; one patient was considered to have achieved partial remission, and the remaining two patients were considered in non-remission. The overall response rate (ORR) to CDHAG was 71.4%. Regarding the side effects, the hematological toxicity level of the seven patients ranged from level III to level IV, and infections that occurred at lung, blood, and skin were recorded. Nausea, vomiting, liver injury, and kidney injury were also detected. However, all side effects were attenuated by proper management. The CDHAG regimen clearly improved the ORR (71.4%) of TP53-mutated AML patients, with no severe side effects. |
| キーワード | acute myeloid leukemia chidamide decitabine HAG TP53 mutation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 63 |
| 終了ページ | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237000 |
| Web of Science KeyUT | 000762812700009 |
| JaLCDOI | 10.18926/AMO/62812 |
|---|---|
| フルテキストURL | 75_6_719.pdf |
| 著者 | Uehara, Shinya| Fujio, Kei| Yamasaki, Tomoya| Otsuki, Hideo| |
| 抄録 | Differentiating patients by age and causative bacterial morphology might aid in making the appropriate choice of antimicrobial agent when treating acute uncomplicated cystitis. In this retrospective analysis, the non-susceptibility rates of the causative bacteria to cefcapene-pivoxil (CFPN-PI) and levofloxacin (LVFX) were determined after dividing patients with acute uncomplicated cystitis by age group (15-54 and 55-74 years old) and by bacterial morphology: gram-positive cocci (GPC) or gram-negative rod (GNR). The overall non-susceptibility rates for CFPN-PI and LVFX were 19.4% and 15.3%, respectively. When the subjects were divided by age, only the non-susceptibility rate for LVFX in the younger group significantly decreased (to 8.7%). When the groups were divided by both age and bacterial morphology, the younger GNR group had non-susceptibility rates of 6.9% to CFPN-PI and 7.8% to LVFX, whereas the younger GPC group showed 10.2% non-susceptibility to LVFX. The older GNR group showed 9.8% non-susceptibility to CFPN-PI, while the older GPC group showed 7.2% non-susceptibility to LVFX. All the non-susceptibility rates were lower than 10.2% in the sub-divided groups. Differentiating patients by age and the morphology of causative bacteria can aid in making the appropriate choice of antimicrobial agent and may improve treatment outcomes in patients with acute uncomplicated cystitis. |
| キーワード | acute uncomplicated cystitis oral antimicrobial agents antimicrobial susceptibility menopause Gram stain |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 719 |
| 終了ページ | 724 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955540 |
| Web of Science KeyUT | 000735297900008 |
| NAID | 120007180280 |
| フルテキストURL | fulltext20211019-2a.pdf Suppl20211019-2.pdf |
|---|---|
| 著者 | Matsui, Hidehito| Uchiyama, Jumpei| Ogata, Masaya| Nasukawa, Tadahiro| Takemura-Uchiyama, Iyo| Kato, Shin-ichiro| Murakami, Hironobu| Higashide, Masato| Hanaki, Hideaki| |
| 発行日 | 2021-9-3 |
| 出版物タイトル | Microbiology Spectrum |
| 巻 | 9巻 |
| 号 | 1号 |
| 出版者 | American Society for Microbiology |
| 開始ページ | e00077-21 |
| ISSN | 2165-0497 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 Matsui et al. |
| 論文のバージョン | publisher |
| PubMed ID | 34378963 |
| DOI | 10.1128/spectrum.00077-21 |
| Web of Science KeyUT | 000703076500019 |
| 関連URL | isVersionOf https://doi.org/10.1128/spectrum.00077-21 |
| タイトル（別表記） | Effectiveness of the National Early Warning Score in the diagnosis of sepsis as defined by Sepsis-3 criteria in cancer patients |
|---|---|
| フルテキストURL | 133_109.pdf |
| 著者 | 劉 丹| 松三 絢弥| 税田 絋輔| 佐藤 哲文| |
| 抄録 | The third international consensus definition of sepsis (Sepsis-3) recommends the quick sequential organ failure assessment (qSOFA) screening tool in patients with suspected infection. The Early Warning Score (EWS) helps to estimate mortality risk in emergency patients. The National EWS (NEWS) is a bedside score of six routine vital parameters. Few studies have compared qSOFA and NEWS in detecting suspected sepsis in cancer patients, so we compared them as a Sepsis-3 prognostic tool. [Methods] This is a retrospective observational single-center study. The study population consisted of cancer patients who entered the intensive care unit (ICU) between 2014 and 2016 for Sepsis-1 (based on systemic inflammatory response syndrome [SIRS] criteria). We calculated and compared the sensitivity and specificity of qSOFA and NEWS. We performed a receiver operating characteristic (ROC) curve analysis of NEWS in the diagnosis of Sepsis-3. [Results] Of the 62 patients admitted to the ICU for Sepsis-1, 42 had Sepsis-3. For qSOFA, sensitivity was 0.71 and specificity was 0.75. Exploratory analysis using the Youden index suggested that 9 may be the optimal score for NEWS. The sensitivity and specificity of NEWS at 9 points were 0.81 and 0.95, respectively. [Conclusion] We found NEWS to be more accurate than qSOFA in screening for Sepsis-3. |
| キーワード | 敗血症（sepsis） スクリーニング（screcning） qSOFA EWS SOFA score |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2021-08-02 |
| 巻 | 133巻 |
| 号 | 2号 |
| 開始ページ | 109 |
| 終了ページ | 112 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.133.109 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2021 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.133.109 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsumoto, Naomi| Kadowaki, Tomoka| Tsukahara, Hirokazu| Yorifuji, Takashi| |
| キーワード | dental caries influenza birth cohort oral health |
| 発行日 | 2021-09-06 |
| 出版物タイトル | Children-Basel |
| 巻 | 8巻 |
| 号 | 9号 |
| 出版者 | MDPI |
| 開始ページ | 780 |
| ISSN | 2227-9067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 34572212 |
| DOI | 10.3390/children8090780 |
| Web of Science KeyUT | 000699412100001 |
| 関連URL | isVersionOf https://doi.org/10.3390/children8090780 |
| JaLCDOI | 10.18926/AMO/62403 |
|---|---|
| フルテキストURL | 75_4_505.pdf |
| 著者 | Okamura, Tomoka| Washio, Yosuke| Watanabe, Hirokazu| Nakanishi, Hidehiko| Uchiyama, Atsushi| Tsukahara, Hirokazu| Kusuda, Satoshi| |
| 抄録 | Late-onset circulatory collapse (LCC) in preterm infants is presumably caused by relative adrenal insufficiency. Because eosinophilia is known to be associated with adrenal insufficiency, we attempted to clarify the relation-ship between eosinophilia and LCC in preterm infants. We divided the cases of the infants (born at < 28 weeks’ gestation) admitted to our neonatal intensive care unit in 2008-2010 into 2 groups: those diagnosed with LCC that received glucocorticoids (LCC group), and those who did not receive glucocorticoids (control group). We compared eosinophil counts between the 2 groups and between before and after glucocorticoid treatment in the LCC group. A total of 28 infants were examined: LCC group (n = 12); control group (n = 16). The peak eosin-ophil counts of the LCC group were significantly higher than those of the control group (median: 1.392 × 109/L vs. 1.033 × 109/L, respectively; p = 0.02). Additionally, in the LCC group, the eosinophil counts declined significantly after glucocorticoid treatment (0.877 × 109/L vs. 0.271 × 109/L, p = 0.003). Eosinophil counts in the LCC group were significantly higher than in the control group and decreased rapidly after gluco-corticoid treatment. These results indicate that eosinophilia may be a factor associated with LCC caused by adrenal insufficiency. |
| キーワード | late-onset circulatory collapse preterm infant eosinophilia steroid adrenal insufficiency |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 505 |
| 終了ページ | 509 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511618 |
| Web of Science KeyUT | 000709282300004 |
| NAID | 120007146046 |
| JaLCDOI | 10.18926/AMO/62401 |
|---|---|
| フルテキストURL | 75_4_487.pdf |
| 著者 | Kunna, Ezzan| Yamamoto, Taro| Nundu, Sabin| Akintije, Calliope | Elkhidir, Isam | |
| 抄録 | Ebola virus disease (EVD) is a highly contagious and fatal disease in humans. Healthcare providers (HCPs) are often at the frontline of epidemics and can thus be in jeopardy of contracting EVD. Sudan is at a great risk of an EVD outbreak, as it borders countries that experienced EVD outbreaks. It is therefore imperative in Sudan to assess the HCPs’ awareness and knowledge, attitude, and practice (KAP) about EVD for its control and man-agement and for preparedness. A KAP survey was conducted among 387 HCPs (physicians, nurses and labora-tory technicians) in the three main tertiary hospitals in Khartoum, Sudan. The majority of the survey respon-dents (54.5%) were females, < 30 years old (76.3%), and single (77.4%). Most (94%) had heard about EVD, 62% from classical media. Only 14% had received education or training regarding EVD. About 40% reported being adherent to universal precautions and 72% were willing to deal with EVD patients under safety precau-tions. Only 10% knew of any available standard national guidelines for EVD. Nearly half of the HCPs (47%) rated the potential risk of an EVD outbreak in Sudan as high, and 52% rated health authorities’ effort against it as weak. These findings revealed the HCPs’ insufficient knowledge of EVD and the necessary universal precau-tions. This lack of knowledge would negatively affect the HCPs’ preparedness toward any potential EVD out-break. There is a dire need to train HCPs in Sudan on the management of EVD, including preventive and con-trol measures. |
| キーワード | Ebola virus Sudan healthcare provider knowledge attitude and practice |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 487 |
| 終了ページ | 493 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511616 |
| Web of Science KeyUT | 000709282300002 |
| NAID | 120007146044 |
| JaLCDOI | 10.18926/AMO/62399 |
|---|---|
| フルテキストURL | 75_4_471.pdf |
| 著者 | Iwamuro, Masaya| Toyokawa, Tatsuya| Matsueda, Kazuhiro| Hori, Shinichiro| Yoshioka, Masao| Moritou, Yuki| Tanaka, Takehiro| Mizuno, Motowo| Okada, Hiroyuki| |
| 抄録 | The characteristics of gastric polyps in patients with Peutz-Jeghers (PJ) syndrome (PJS) have not been fully investigated. The objective of this study was to reveal the endoscopic and pathologic findings of gastric polyps in patients with PJS. We reviewed 11 patients with PJS treated at 6 institutions, and summarized the endo-scopic and pathologic features of their gastric polyps. The polyps were mainly classified into 2 types: (i) soli-tary or sporadic polyps > 5 mm, reddish in color with a sessile or semi-pedunculated morphology (n = 9); and (ii) multiple sessile polyps ≤ 5 mm with the same color tone as the peripheral mucosa (n = 9). Patients who underwent endoscopic mucosal resection for polyps > 5 mm were diagnosed with PJ polyps (n = 2), whereas those who underwent biopsy were diagnosed with hyperplastic polyps. Polyps ≤ 5 mm were pathologically diagnosed as fundic gland polyps or hyperplastic polyps. This study revealed that patients with PJS present with 2 types of polyps in the stomach. Endoscopic mucosal resection of polyps > 5 mm seems necessary for the pathologic diagnosis of PJ polyps. |
| キーワード | Peutz-Jeghers syndrome esophagogastroduodenoscopy gastric polyps |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 471 |
| 終了ページ | 477 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511614 |
| Web of Science KeyUT | 000701717000001 |
| NAID | 120007146042 |
| JaLCDOI | 10.18926/AMO/62398 |
|---|---|
| フルテキストURL | 75_4_461.pdf |
| 著者 | Murakami, Hiroyuki| Yoshioka, Takanori| Moriyama, Takashi| Ishikawa, Tatsunori| Makita, Masanori| Sunami, Kazutaka| |
| 抄録 | Bendamustine plus rituximab (B-R) is an effective therapy for relapsed or refractory (r/r) low-grade B-cell lymphoma (LGBCL) and mantle cell lymphoma (MCL); however, clinical data from Japanese patients treated with B-R therapy are limited. We retrospectively evaluated the efficacy and safety of B-R therapy in 42 patients who received B-R therapy at our hospital for r/r LGBCL and MCL. All patients received intravenous (IV) ritux-imab 375 mg/m2 on day 1 and IV bendamustine 90 mg/m2 on days 2 and 3 every 28 days for up to 6 cycles. The common histologic subtypes were follicular lymphoma (n = 29, 70%), marginal zone lymphoma (n = 6, 14%), and MCL (n = 5, 12%). The overall response rate was 93%, with 62% complete response and complete response unconfirmed. The median progression-free survival (PFS) was 38 months (95% confidence interval [CI], 24.6 to not reached [NR]), and the median overall survival (OS) was 80 months (95% CI, 60.7 to NR). Patients receiving a cumulative dose of bendamustine ≥ 720 mg/m2 showed a significantly longer PFS and OS. Grade 3/4 adverse events (≥ 10%) included neutropenia (55%), lymphopenia (69%), and nausea (24%). B-R therapy was effective and well tolerated, and the cumulative dose of bendamustine was associated with a favorable outcome. |
| キーワード | bendamustine low grade B-cell lymphoma mantle cell lymphoma |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-08 |
| 巻 | 75巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 461 |
| 終了ページ | 469 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34511613 |
| Web of Science KeyUT | 000697944600008 |
| NAID | 120007146041 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Obata, Kyoichi| Okui, Tatsuo| Ono, Sawako| Umemori, Koki| Ryumon, Shoji| Ono, Kisho| Yao, Mayumi| Yoshioka, Norie| Ibaragi, Soichiro| Sasaki, Akira| |
| キーワード | methotrexate lymphoproliferative disorders Epstein-Barr virus mucocutaneous ulcer rheumatoid arthritis |
| 発行日 | 2021-07-30 |
| 出版物タイトル | Diagnostics |
| 巻 | 11巻 |
| 号 | 8号 |
| 出版者 | MDPI |
| 開始ページ | 1375 |
| ISSN | 2075-4418 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 34441310 |
| DOI | 10.3390/diagnostics11081375 |
| Web of Science KeyUT | 000688919100001 |
| 関連URL | isVersionOf https://doi.org/10.3390/diagnostics11081375 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hamaguchi, Hisashi| Yumoto, Tetsuya| Mae, Soichiro| Takeshita, Ayumu| Aoyama, Minae| Yamana, Keiya| Nakao, Atsunori| |
| キーワード | Hyperostosis diffuse idiopathic skeletal spinal injuries traumatology urinary retention |
| 発行日 | 2021-06-23 |
| 出版物タイトル | Clinical Medicine Insights-Case Reports |
| 巻 | 14巻 |
| 出版者 | Sage Publications Ltd |
| 開始ページ | 1 |
| 終了ページ | 3 |
| ISSN | 1179-5476 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2021 |
| 論文のバージョン | publisher |
| PubMed ID | 34248361 |
| DOI | 10.1177/11795476211027988 |
| Web of Science KeyUT | 000688111200001 |
| 関連URL | isVersionOf https://doi.org/10.1177/11795476211027988 |
| JaLCDOI | 10.18926/AMO/62221 |
|---|---|
| フルテキストURL | 75_3_299.pdf |
| 著者 | Araki, Jo| Oka, Kosuke| Yamamoto, Koichiro| Hanayama, Yoshihisa | Tokumasu, Kazuki| Hagiya, Hideharu| Ogawa, Hiroko| Itoshima, Koichi| Otsuka, Fumio| |
| 抄録 | Various laboratory markers of inflammation are utilized in general practice, but their clinical diagnostic significance is often ambiguous. In the present study, we determined the clinical significance of the examination of serum levels of procalcitonin (PCT) by comparing the PCT levels with the levels of other inflammatory markers, based on a retrospective review of 332 PCT-positive patients, including cases of bacterial infection (20.5%), non-specific inflammation (20.8%), neoplasm (9.9%), connective tissue diseases (8.4%), and non-bacterial infection (7.2%), were analyzed. The serum PCT level was highest in the bacterial infection group (1.94 ng/ml) followed by the non-specific inflammatory group (0.58 ng/ml) and neoplastic diseases group (0.34 ng/ml). The serum PCT level was positively correlated with serum levels of C-reactive protein (rho=0.62), soluble interleukin-2 receptor (sIL-2R; rho=0.69), and ferritin, the plasma level of D-dimer, and white blood cell count, and negatively correlated with the serum albumin level (rho=−0.52), hemoglobin concentration, and platelet count. The serum PCT level showed a stronger positive correlation with the serum sIL-2R level than the other biomarkers. The results suggest that an increased PCT level may indicate not only an infectious state but also a non-bacterial inflammatory condition in the diagnostic process in general practice. |
| キーワード | bacterial infection inflammation malignant lymphoma procalcitonin soluble interleukin-2 receptor |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-06 |
| 巻 | 75巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 299 |
| 終了ページ | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34176933 |
| Web of Science KeyUT | 000667147700005 |
| NAID | 120007089836 |
| JaLCDOI | 10.18926/AMO/62219 |
|---|---|
| フルテキストURL | 75_3_279.pdf |
| 著者 | Nishinohara, Masa-aki| Nishimori, Hisakazu| Fujiwara, Hideaki| Asada, Noboru| Ennishi, Daisuke| Matsuoka, Ken-ichi| Fujii, Keiko| Fujii, Nobuharu| Maeda, Yoshinobu| |
| 抄録 | A bloodstream infection (BSI) is the most common serious infectious complication of hematopoietic stem cell transplantation (HSCT). BSI promotes an inflammatory state, which exacerbates acute graft-versus-host disease (GVHD). We investigated whether a Gram-negative rod bloodstream infection (GNR-BSI), which develops early after allo-HSCT, affected the onset or exacerbated acute GVHD in 465 patients who underwent allo-HSCT from 1995 through 2015 at a single institution. Eighty-eight patients (19%) developed BSI during the study period. Among the cultures, 50 (57%) were Gram-positive cocci (GPC) and 31 (35%) were GNR. Of the 465 patients, 187 (40%) developed acute GVHD of grade II or higher within the first 100 days post-allogeneic HSCT: 124 (27%) had acute GVHD grade II, 47 (10%) had grade III, and 16 (3%) had grade IV. Multivariate analysis revealed that GNR-BSI was a significant risk factor for grade II-IV acute GVHD (grade II-IV: hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.03-2.97; grade III-IV: HR 2.37, 95% CI 1.03-5.43). These results suggest that GNR-BSI may predict the onset and exacerbation of acute GVHD. |
| キーワード | blood stream infection graft-versus-host disease gram negative rods |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-06 |
| 巻 | 75巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 279 |
| 終了ページ | 287 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34176931 |
| Web of Science KeyUT | 000667147700003 |
| NAID | 120007089834 |