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JaLCDOI 10.18926/AMO/64112
FullText URL 76_6_625.pdf
Author Liu Zhisheng| Li, Qingmei| Wang, Ye| Ge, Yunjie|
Abstract This investigation aimed to uncover the impact of a long noncoding RNA, SET-binding factor 2 antisense RNA1 (SBF2-AS1) on the malignant progression of gastric cancer (GC) and to further explore its underlying mechanism. SBF2-AS1 expression was quantified by qRT-PCR in GC cell lines and GC tissues. In vitro loss-of-function studies of SBF2-AS1, accompanied by flow cytometry, CCK-8, and cell invasion tests, were applied to elucidate the impact of SBF2-AS1 on the tumor progression of GC cells. Finally, Western blotting and a luciferase assay were used to detect WNT/LRP5 signaling pathway activation. SBF2-AS1 was aberrantly expressed in GC cell lines (p<0.05) and GC tissues (p<0.05). Cell invasive and proliferative capabilities were inhibited via SBF2-AS1 knockdown, resulting in apoptosis of NCI-N87 and MKN74 cells. Additionally, online database analysis uncovered a positive correlation between SBF2-AS1 and the Wnt/LRP5 signaling pathway (p<0.05). SBF2-AS1 knockdown blocked the Wnt/LRP5 signaling pathway, whereas the effects of SBF2-AS1 knockdown on the malignant genotype of MKN74 as well as NCI-N87 cells were partially restored by triggering the Wnt/ LRP5 signaling pathway. High expression of SBF2-AS1 was found in GC, the malignant progression of which was repressed via SBF2-AS1 knockdown by inhibiting the Wnt/LRP5 signaling pathway.
Keywords gastric cancer (GC) SET-binding factor 2 antisense RNA1 (SBF2-AS1) invasion proliferation signaling
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-12
Volume volume76
Issue issue6
Publisher Okayama University Medical School
Start Page 625
End Page 633
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36549764
Web of Science KeyUT 000905195100002
FullText URL K0006703_abstract_review.pdf K0006703_summary.pdf K0006703_fulltext.pdf
Author FUJIHARA, Miwa|
Published Date 2022-09-22
Content Type Thesis or Dissertation
Grant Number 甲第6703号
Granted Date 2022-09-22
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2021 by the authors.
FullText URL K0006700_abstract_review.pdf K0006700_fulltext.pdf K0006700_summary.pdf
Author KAJIWARA, Yukiko|
Published Date 2022-09-22
Content Type Thesis or Dissertation
Grant Number 甲第6700号
Granted Date 2022-09-22
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
FullText URL K0006690_abstract_review.pdf K0006690_fulltext.pdf K0006690_summary.pdf
Author TSUKIOKI, Takahiro|
Published Date 2022-09-22
Content Type Thesis or Dissertation
Grant Number 甲第6690号
Granted Date 2022-09-22
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © The Author(s) 2020
FullText URL K0006688_abstract_review.pdf K0006688_fulltext.pdf K0006688_summary.pdf
Author ABE, Yuko|
Published Date 2022-09-22
Content Type Thesis or Dissertation
Grant Number 甲第6688号
Granted Date 2022-09-22
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2022 by Okayama University Medical School.
JaLCDOI 10.18926/AMO/64041
FullText URL 76_5_593.pdf
Author Noumi, Taku| Watanabe, Hiromi| Ninomiya, Kiichiro| Ohashi, Kadoaki| Ichihara, Eiki| Kubo, Toshio| Makimoto, Go| Kato, Yuka| Fujii, Masanori| Tabata, Masahiro| Maeda, Yoshinobu| Hotta, Katsuyuki| Kiura, Katsuyuki|
Abstract We encountered a woman with re-enlarged axillary lymph nodes during a computed tomography (CT) scan for surveillance of lung adenocarcinoma with axillary lymph node metastasis at the initial diagnosis that had shrunk with standard chemotherapy. We first suspected cancer recurrence and considered a change in the chemotherapeutic regimen. However, after careful history taking regarding the timing of her Coronavirus Disease 2019 (COVID-19) vaccination, and subsequent careful, close follow-up, radiological shrinkage suggested a strictly benign cause. Especially in lung cancer with a medical history of axillary lymph node involvement, cliniciansshould be aware that vaccine-associated lymphadenopathy can mimic cancer recurrence and sometimesprompt serious misjudgment regarding a current treatment course and strategy.
Keywords lung cancer COVID-19 vaccination axillary lymphadenopathy case report
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 593
End Page 596
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352807
Web of Science KeyUT 000884907100013
FullText URL fulltext.pdf
Author Fithroni, Abdul Basith| Kobayashi, Kazuko| Uji, Hirotaka| Ishimoto, Manabu| Akehi, Masaru| Ohtsuki, Takashi| Matsuura, Eiji|
Keywords boron neutron capture therapy (BNCT) biologically self-degradable amphipathic polymer (Lactosome) hydrophobic boron cluster carborane isomers or o-carborane alkylated derivatives molecular glue effect
Published Date 2022-10-21
Publication Title CELLS
Volume volume11
Issue issue20
Publisher MDPI
Start Page 3307
ISSN 2073-4409
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36291173
DOI 10.3390/cells11203307
Web of Science KeyUT 000872497500001
Related Url isVersionOf https://doi.org/10.3390/cells11203307
FullText URL fulltext.pdf
Author Shigehiro, Tsukasa| Ueno, Maho| Kijihira, Mayumi| Takahashi, Ryotaro| Umemura, Chiho| Taha, Eman A.| Kurosaka, Chisaki| Asayama, Megumi| Murakami, Hiroshi| Satoh, Ayano| Nakamura, Yoshimasa| Futami, Junichiro| Masuda, Junko|
Keywords breast cancer cells dendritic cells mesenteric lymph node myeloid-derived suppressor cells
Published Date 2022-09-20
Publication Title International Journal Of Molecular Sciences
Volume volume23
Issue issue19
Publisher MDPI
Start Page 11035
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36232335
DOI 10.3390/ijms231911035
Web of Science KeyUT 000867767200001
Related Url isVersionOf https://doi.org/10.3390/ijms231911035
FullText URL fulltext.pdf
Author Tomonobu, Nahoko| Kinoshita, Rie| Wake, Hidenori| Inoue, Yusuke| Ruma, I. Made Winarsa| Suzawa, Ken| Gohara, Yuma| Komalasari, Ni Luh Gede Yoni| Jiang, Fan| Murata, Hitoshi| Yamamoto, Ken-Ichi| Sumardika, I. Wayan| Chen, Youyi| Futami, Junichiro| Yamauchi, Akira| Kuribayashi, Futoshi| Kondo, Eisaku| Toyooka, Shinichi| Nishibori, Masahiro| Sakaguchi, Masakiyo|
Keywords S100A8/A9 HRG metastasis
Published Date 2022-09-07
Publication Title International Journal Of Molecular Sciences
Volume volume23
Issue issue18
Publisher MDPI
Start Page 10300
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36142212
DOI 10.3390/ijms231810300
Web of Science KeyUT 000858719600001
Related Url isVersionOf https://doi.org/10.3390/ijms231810300
FullText URL fulltext.pdf
Author Li, Chunning| Yoshimura, Teizo| Tian, Miao| Wang, Yuze| Kondo, Takamasa| Yamamoto, Ken-Ichi| Fujisawa, Masayoshi| Ohara, Toshiaki| Sakaguchi, Masakiyo| Matsukawa, Akihiro|
Keywords Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment
Published Date 2022-09-12
Publication Title Breast Cancer Research
Volume volume24
Issue issue1
Publisher BMC
Start Page 60
ISSN 1465-5411
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 36096830
DOI 10.1186/s13058-022-01557-5
Web of Science KeyUT 000853036400001
Related Url isVersionOf https://doi.org/10.1186/s13058-022-01557-5
JaLCDOI 10.18926/AMO/63908
FullText URL 76_4_479.pdf
Author Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi|
Abstract A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance.
Keywords hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 479
End Page 483
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123164
Web of Science KeyUT 000882167300012
JaLCDOI 10.18926/AMO/63894
FullText URL 76_4_399.pdf
Author Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
Abstract According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67.
Keywords breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 399
End Page 408
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123154
Web of Science KeyUT 000882167300005
JaLCDOI 10.18926/AMO/63893
FullText URL 76_4_391.pdf
Author Habu, Hiroshi| Mitsuhashi, Toshiharu| Tokinobu, Akiko| Yorifuji, Takashi| Takao, Soshi|
Abstract Tanden breathing, an ancient health technique, involves expiratory abdominal pressure breathing is practiced in Japan. In this study we examined the ability of Tanden breathing to relieve constipation. The study was designed as a stratified-block randomized controlled trial enrolling 20 participants. Nineteen were female and one was male, none were elderly. During the 6-week intervention period, the participants performed video-guided Tanden breathing about 10 min once day. We evaluated constipation using the Constipation Assessment Scale (CAS). There were significant differences in the mean CAS score between time points (baseline, 3 weeks after baseline, 6 weeks after baseline), groups (intervention and control), and their interaction (time×group) using repeated-measures analysis of variance. The control group showed no change in the mean CAS score; the mean CAS scores of the intervention group changed from 7.2 at baseline to 3.9 at 3 weeks and 3.1 at 6 weeks after baseline. A regression analysis of the difference in the mean CAS between baseline and 6 weeks later showed that the CAS of the intervention group was 4.3 points lower than that of the control group (95% confidence interval, 2.5-6.1). The results suggested that Tanden breathing is effective in relieving constipation among young women.
Keywords Tanden breathing Dantian breathing exercises constipation mind−body therapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 391
End Page 398
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123153
Web of Science KeyUT 000882167300001
JaLCDOI 10.18926/AMO/63887
FullText URL 76_4_359.pdf
Author Hiramatsu-Asano, Sumie| Wada, Jun|
Abstract Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE.
Keywords systemic lupus erythematosus miRNA miRNA targeting therapy
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 359
End Page 371
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123150
Web of Science KeyUT 000882167300002
FullText URL fulltext.pdf
Author Okazaki, Mikio| Shien, Kazuhiko| Suzawa, Ken| Sugimoto, Seiichiro| Toyooka, Shinichi|
Keywords robot robot-assisted thoracic surgery mediastinal tumor thymectomy port placement
Published Date 2022-07-22
Publication Title Journal Of Personalized Medicine
Volume volume12
Issue issue8
Publisher MDPI
Start Page 1195
ISSN 2075-4426
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35893289
DOI 10.3390/jpm12081195
Web of Science KeyUT 000845682400001
Related Url isVersionOf https://doi.org/10.3390/jpm12081195
FullText URL fulltext.pdf
Author Ochi, Kosuke| Suzawa, Ken| Thu, Yin Min| Takatsu, Fumiaki| Tsudaka, Shimpei| Zhu, Yidan| Nakata, Kentaro| Takeda, Tatsuaki| Shien, Kazuhiko| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Okamoto, Yoshiharu| Tomida, Shuta| Toyooka, Shinichi|
Keywords cancer-associated fibroblast drug resistance tranilast
Published Date 2022-07-24
Publication Title Cancer Science
Volume volume2022
Publisher Wiley
ISSN 1347-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 35871750
DOI 10.1111/cas.15502
Web of Science KeyUT 000840374000001
Related Url isVersionOf https://doi.org/10.1111/cas.15502
FullText URL fulltext.pdf
Author Hotta, K.| Saeki, S.| Yamaguchi, M.| Harada, D.| Bessho, A.| Tanaka, K.| Inoue, K.| Gemba, K.| Shiojiri, M.| Kato, Y.| Ninomiya, T.| Kubo, T.| Kishimoto, J.| Shioyama, Y.| Katsui, K.| Sasaki, J.| Kiura, K.| Sugio, K.|
Note DOI of original article: https://doi.org/10.1016/j.esmoop.2021.100191 |
Published Date 2022-08
Publication Title ESMO OPEN
Volume volume7
Issue issue4
Publisher ELSEVIER
ISSN 2059-7029
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35802950
DOI 10.1016/j.esmoop.2022.100532
Web of Science KeyUT 000828209200003
Related Url isVersionOf https://doi.org/10.1016/j.esmoop.2022.100532 https://doi.org/10.1016/j.esmoop.2021.100191
FullText URL fulltext20220715-3.pdf
Author Niman, Eito| Miyoshi, Kentaroh| Shiotani, Toshio| Toji, Tomohiro| Igawa, Takuro| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Toyooka, Shinichi|
Keywords Lung transplantation (LTx) lung recruitment maneuver atelectasis protective procurement
Published Date 2022-07-12
Publication Title Journal of Thoracic Disease
Publisher AME Publishing Company
ISSN 2072-1439
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Journal of Thoracic Disease.
File Version publisher
DOI 10.21037/jtd-22-226
Web of Science KeyUT 000821133100001
Related Url isVersionOf https://doi.org/10.21037/jtd-22-226
JaLCDOI 10.18926/AMO/63739
FullText URL 76_3_297.pdf
Author Kuroda, Masahiro| Konishi, Kohei| Sugimoto, Kohei| Yoshimura, Yuuki| Hamada, Kentaro| Khasawnehc, Abdullah| Barham, Majd| Tekiki, Nouha| Sugianto, Irfan| Bamgbose, Babatunde O.| Ishizaka, Hinata| Shimizu, Yudai| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Kamizaki, Ryo| Kurozumi, Akira| Matsushita, Toshi| Ohno, Seiichiro| Kanazawa, Susumu| Asaumi, Junichi|
Abstract Clinical research using restricted diffusion-weighted imaging, especially diffusion kurtosis (DK) imaging, has been progressing, with reports on its effectiveness in the diagnostic imaging of cerebral infarctions, neurodegenerative diseases, and tumors, among others. However, the application of DK imaging in daily clinical practice has not spread because of the long imaging time required and the use of specific software for image creation. Herein, with the aim of promoting clinical research using DK imaging at any medical facility, we evaluated fast DK imaging using a new software program. We developed a new macro program that produces DK images using general-purpose, inexpensive software (Microsoft Excel and ImageJ), and we evaluated fast DK imaging using bio-phantoms and a healthy volunteer in clinical trials. The DK images created by the new software with diffusion-weighted images captured with short-time imaging sequences were similar to the original DK images captured with long-time imaging sequences. The DK images using three b-values, which can reduce the imaging time by 43%, were equivalent to the DK images using five b-values. The DK imaging technique developed herein might allow any medical facility to increase its daily clinical use of DK imaging and easily conduct clinical research.
Keywords fast diffusion kurtosis imaging mean kurtosis restricted diffusion Excel ImageJ
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 297
End Page 305
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790360
Web of Science KeyUT 000823568300009
FullText URL fulltext.pdf
Author Nishimura, Yoshito| Acoba, Jared D.|
Keywords Breast Cancer Awareness Month breast cancer Google Trends trend analysis
Published Date 2022-05-21
Publication Title Cancers
Volume volume14
Issue issue10
Publisher MDPI
Start Page 2534
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35626141
DOI 10.3390/cancers14102534
Web of Science KeyUT 000803386600001
Related Url isVersionOf https://doi.org/10.3390/cancers14102534