result 474 件
| JaLCDOI | 10.18926/AMO/65493 |
|---|---|
| FullText URL | 77_3_281.pdf |
| Author | Mukai, Yuko| Taira, Naruto| Kajiwara, Yukiko| Iwamoto, Takayuki| Kitaguchi, Yohei| Saiga, Miho| Watanabe, Satoko| Shien, Tadahiko| Doihara, Hiroyoshi| Kimata, Yoshihiro| |
| Abstract | Although immediate breast reconstruction following mastectomy has become increasingly common, its oncological safety has been debated. We enrolled patients with breast cancer who underwent surgery at Okayama University Hospital between 2007 and 2013. The primary outcome was relapse-free survival (RFS). Secondary outcomes were overall survival and the duration from the surgery to the initiation of adjuvant chemotherapy. We divided into immediate breast reconstruction, mastectomy alone, and breast conservative surgery groups. Outcomes were compared using Cox’s regression analysis. A total of 614 patients were included (reconstruction: 125, mastectomy: 128, breast conservative surgery: 361). The median follow-up duration was 79.0±31.9 months. The immediate-reconstruction patients were younger, had more lymph node metastases, and more often received postoperative chemotherapy. The RFS was better after the breast conservative surgery compared to after reconstruction (hazard ratio 0.33, 95% confidence interval: 0.144-0.763). The proportion of local recurrence was highest in the reconstruction group. No patients in the reconstruction group underwent postoperative radiation therapy. However, reconstruction did not affect overall survival or the time to the initiation of adjuvant chemotherapy. Surgeons should explain the risks of breast reconstruction to their patients preoperatively. Careful long-term follow-up is required after such procedures. |
| Keywords | immediate breast reconstruction oncological safety local recurrence postoperative radiation therapy time to initiation of adjuvant chemotherapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 281 |
| End Page | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357629 |
| Web of Science KeyUT | 001026279600006 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shiotani, Toshio| Sugimoto, Seiichiro| Tomioka, Yasuaki| Yamamoto, Haruchika| Tanaka, Shin| Miyoshi, Kentaroh| Suzawa, Ken| Shien, Kazuhiko| Yamamoto, Hiromasa| Okazaki, Mikio| Toyooka, Shinichi| |
| Keywords | Biomarker Chronic lung allograft dysfunction Lung transplantation Living -donor lobar lung transplantation Micro-RNA |
| Published Date | 2023-04 |
| Publication Title | Heliyon |
| Volume | volume9 |
| Issue | issue4 |
| Publisher | Elsevier |
| Start Page | e14903 |
| ISSN | 2405-8440 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 37025782 |
| DOI | 10.1016/j.heliyon.2023.e14903 |
| Web of Science KeyUT | 000998641100001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.heliyon.2023.e14903 |
| FullText URL | K0006805_abstract_review.pdf K0006805_fulltext.pdf K0006805_summary.pdf |
|---|---|
| Author | ZHU, YIDAN| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6805号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © The Author(s), under exclusive licence to The Japanese Breast Cancer Society 2022 |
| FullText URL | K0006778_abstract_review.pdf K0006778_fulltext.pdf K0006778_other.pdf |
|---|---|
| Author | LI, CHUNNING| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6778号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © The Author(s) 2022. |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawana, Shinichi| Miyoshi, Kentaroh| Tanaka, Shin| Sugimoto, Seiichiro| Shimizu, Dai| Matsubara, Kei| Okazaki, Mikio| Hattori, Noboru| Toyooka, Shinichi| |
| Keywords | graft dysfunction immunosuppression lung transplantation pulmonary alveolar proteinosis |
| Published Date | 2023-05-23 |
| Publication Title | Respirology Case Reports |
| Volume | volume11 |
| Issue | issue6 |
| Publisher | Wiley |
| Start Page | e01160 |
| ISSN | 2051-3380 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 37229297 |
| DOI | 10.1002/rcr2.1160 |
| Web of Science KeyUT | 000992419400001 |
| Related Url | isVersionOf https://doi.org/10.1002/rcr2.1160 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Shunki| Kosaki, Yoshinori| Uehara, Takenori| Naito, Hiromichi| Nakao, Atsunori| |
| Keywords | case report breast hematoma chest injury seat belt injury traffic injury |
| Published Date | 2023-02-25 |
| Publication Title | Cureus |
| Volume | volume15 |
| Issue | issue2 |
| Publisher | Springer |
| Start Page | e35440 |
| ISSN | 2168-8184 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Yamamoto et al. |
| File Version | publisher |
| PubMed ID | 36994269 |
| DOI | 10.7759/cureus.35440 |
| Web of Science KeyUT | 000978767800001 |
| Related Url | isVersionOf https://doi.org/10.7759/cureus.35440 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Akezaki, Yoshiteru| Nakata, Eiji| Kikuuchi, Masato| Sugihara, Shinsuke| Katayama, Yoshimi| Katayama, Haruyoshi| Hamada, Masanori| Ozaki, Toshifumi| |
| Keywords | spinal bone metastases radiotherapy chemotherapy activities of daily living overall survival |
| Published Date | 2022-02-11 |
| Publication Title | Healthcare |
| Volume | volume10 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 350 |
| ISSN | 2227-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35206964 |
| DOI | 10.3390/healthcare10020350 |
| Web of Science KeyUT | 000976128500003 |
| Related Url | isVersionOf https://doi.org/10.3390/healthcare10020350 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Komalasari, Ni Luh Gede Yoni| Tomonobu, Nahoko| Kinoshita, Rie| Chen, Youyi| Sakaguchi, Yoshihiko| Gohara, Yuma| Jiang, Fan| Yamamoto, Ken-Ich| Murata, Hitoshi| Ruma, I Made Winarsa| Sumardika, I Wayan| Zhou, Jin| Yamauchi, Akira| Kuribayashi, Futoshi| Inoue, Yusuke| Toyooka, Shinichi| Sakaguchi, Masakiyo| |
| Keywords | breast cancer lysyl oxidase annexin A2 integrin cancer microenvironment |
| Published Date | 2023-04-04 |
| Publication Title | Frontiers in Oncology |
| Volume | volume13 |
| Publisher | Frontiers Media |
| Start Page | 1142907 |
| ISSN | 2234-943X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Komalasari, Tomonobu, Kinoshita, Chen, Sakaguchi, Gohara, Jiang, Yamamoto, Murata, Ruma, Sumardika, Zhou, Yamauchi, Kuribayashi, Inoue, Toyooka and Sakaguchi. |
| File Version | publisher |
| PubMed ID | 37091157 |
| DOI | 10.3389/fonc.2023.1142907 |
| Web of Science KeyUT | 000970195800001 |
| Related Url | isVersionOf https://doi.org/10.3389/fonc.2023.1142907 |
| JaLCDOI | 10.18926/AMO/65143 |
|---|---|
| FullText URL | 77_2_139.pdf |
| Author | Namio, Keiichi| Kondo, Takashi| Miyatake, Nobuyuki| Hishii, Shuhei| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Suzuki, Hiromi| Koumoto, Kiichi| |
| Abstract | We investigated the link between prolonged sedentary bouts and all-cause mortality in patients on chronic hemodialysis, using a prospective cohort. A total of 104 outpatients on chronic hemodialysis from 2013 to 2019, aged 71.4±11.4 years, were enrolled. Prolonged sedentary bouts (≥ 30 min and ≥60 min) (min and bouts) and relative prolonged sedentary bouts (≥ 30 min and ≥ 60 min) (%) on the patients’ non-hemodialysis days were measured by a tri-accelerometer, and we also analyzed the patients’ clinical parameters. The relationship between prolonged sedentary bouts and all-cause mortality was evaluated by a survival analysis and the Cox proportional hazard model. Thirty-five patients died during the follow-up period. A Kaplan-Meier analysis detected significant differences in the survival rate between two groups stratified by the median for all prolonged sedentary-bout parameters. After the adjustment for confounding factors, all of the prolonged sedentary-bout parameters were determinant factors for all-cause mortality. These results indicate that prolonged sedentary bouts on non-hemodialysis days were closely related to all-cause mortality in the patients on hemodialysis. |
| Keywords | sedentary bout mortality hemodialysis survival analysis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-04 |
| Volume | volume77 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 139 |
| End Page | 145 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37094951 |
| Web of Science KeyUT | 000982503800003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hirabayashi, Daisuke| Yamamoto, Ken-ichi| Maruyama, Akihiro| Tomonobu, Nahoko| Kinoshita, Rie| Chen, Youyi| Komalasari, Ni Luh Gede Yoni| Murata, Hitoshi| Gohara, Yuma| Jiang, Fan| Zhou, Jin| Ruma, I. Made Winarsa| Sumardika, I. Wayan| Yamauchi, Akira| Kuribayashi, Futoshi| Toyooka, Shinichi| Inoue, Yusuke| Sakaguchi, Masakiyo| |
| Keywords | epithelial-to-mesenchymal transition triple-negative breast cancer zinc ZEB1 metastasis |
| Published Date | 2023-02-23 |
| Publication Title | Frontiers in Oncology |
| Volume | volume13 |
| Publisher | Frontiers Media |
| Start Page | 1142886 |
| ISSN | 2234-943X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Hirabayashi, Yamamoto, Maruyama, Tomonobu, Kinoshita, Chen, Komalasari, Murata, Gohara, Jiang, Zhou, Ruma, Sumardika, Yamauchi, Kuribayashi, Toyooka, Inoue and Sakaguchi. |
| File Version | publisher |
| PubMed ID | 36910659 |
| DOI | 10.3389/fonc.2023.1142886 |
| Web of Science KeyUT | 000945660600001 |
| Related Url | isVersionOf https://doi.org/10.3389/fonc.2023.1142886 |
| FullText URL | fulltext20230508-03.pdf |
|---|---|
| Author | Hagiya, Hideharu| Hikita, Takao| Habu, Tomohiro| Asada, Masaki| Yorifuji, Takashi| Toyooka, Shinichi| Otsuka, Fumio| Nakayama, Masanori| |
| Note | © 2022 The British Infection Association. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jinf.2022.07.007. | This fulltext file will be available in Oct. 2023.| |
| Published Date | 2022-10 |
| Publication Title | Journal of Infection |
| Volume | volume85 |
| Issue | issue4 |
| Publisher | Elsevier |
| Start Page | 436 |
| End Page | 480 |
| ISSN | 0163-4453 |
| NCID | AA00258231 |
| Content Type | Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The British Infection Association. |
| File Version | author |
| PubMed ID | 35835411 |
| DOI | 10.1016/j.jinf.2022.07.007 |
| Web of Science KeyUT | 000883125700028 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jinf.2022.07.007 |
| JaLCDOI | 10.18926/AMO/64360 |
|---|---|
| FullText URL | 77_1_37.pdf |
| Author | Yamanouchi, Kosho| Maeda, Shigeto| |
| Abstract | Systemic therapy for stage IV breast cancer is usually an initial treatment and is based on findings regarding biomarkers (e.g., hormone receptors and human epidermal growth factor receptor-2 [HER2]). However, the response to therapy and outcomes sometime differ among patients with similar prognostic factors including grade, hormone receptor, HER2, and more. We conducted retrospective analyses to evaluate the correlations between the overall survival (OS) of 46 stage IV breast cancer patients and (i) the peripheral absolute lymphocyte count (ALC) and (ii) composite blood cell markers. The peripheral blood cell markers included the neutrophil- to-lymphocyte ratio (NLR), the monocyte-to-lymphocyte ratio (MLR), the systemic immune-inflammation index (SII), the systemic inflammation response index (SIRI), and the most recently introduced indicator, the pan-immune-inflammatory value (PIV). The SIRI and PIV showed prognostic impacts on the patients: those with a low SIRI or a low PIV showed significantly better OS than those with a high SIRI (5-year, 66.0% vs. 35.0%, p<0.05) or high PIV (5-year, 68.1% vs. 38.5%, p<0.05), respectively. This is the first report indicating the possible prognostic value of the PIV for OS in patients with stage IV breast cancer. Further studies with larger numbers of patients are necessary for further clarification. |
| Keywords | breast cancer pan-immune-inflammatory value prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 37 |
| End Page | 43 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849144 |
| Web of Science KeyUT | 000952992100001 |
| JaLCDOI | 10.18926/AMO/64356 |
|---|---|
| FullText URL | 77_1_11.pdf |
| Author | Watanabe, Satoko| Saiga, Miho| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Kimata, Yoshihiro| |
| Abstract | The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction. |
| Keywords | breast reconstruction mastectomy brassiere professional bra fitter |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 11 |
| End Page | 19 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849141 |
| Web of Science KeyUT | 000953663800002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Akezaki, Yoshiteru| Nakata, Eiji| Kikuuchi, Masato| Tominaga, Ritsuko| Kurokawa, Hideaki| Okamoto, Masaki| Ozaki, Toshifumi| Aogi, Kenjiro| Ohsumi, Shozo| Sugihara, Shinsuke| |
| Keywords | breast cancer elderly comorbidity upper-limb function rehabilitation |
| Published Date | 2023-01-04 |
| Publication Title | Current Oncology |
| Volume | volume30 |
| Issue | issue1 |
| Publisher | MDPI |
| Start Page | 673 |
| End Page | 680 |
| ISSN | 1198-0052 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 36661701 |
| DOI | 10.3390/curroncol30010052 |
| Web of Science KeyUT | 000914388100001 |
| Related Url | isVersionOf https://doi.org/10.3390/curroncol30010052 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Wang, Yuze| Ohara, Toshiaki| Chen, Yuehua| Hamada, Yusuke| Li, Chunning| Fujisawa, Masayoshi| Yoshimura, Teizo| Matsukawa, Akihiro| |
| Keywords | triple-negative breast cancer iron metabolism iron chelator phosphoinositide-3-kinase-protein kinase heterogeneity metastasis |
| Published Date | 2023-01-12 |
| Publication Title | Cancers |
| Volume | volume15 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 468 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 36672419 |
| DOI | 10.3390/cancers15020468 |
| Web of Science KeyUT | 000914513700001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers15020468 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwatani, Tsuguo| Saito, Shinya| |
| Keywords | parathyroid surgery prophylactic antibiotic risk factor surgical site infection thyroid surgery |
| Published Date | 2022-12-11 |
| Publication Title | International Wound Journal |
| Volume | volume2022 |
| Publisher | Wiley |
| ISSN | 1742-4801 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 36504428 |
| DOI | 10.1111/iwj.14046 |
| Web of Science KeyUT | 000896886400001 |
| Related Url | isVersionOf https://doi.org/10.1111/iwj.14046 |
| FullText URL | fulltext20221223-3.pdf NA_Itano_Fig.pdf supl20221223-3.pdf NA_Itano_Supl.pdf |
|---|---|
| Author | Itano, Junko| Taniguchi, Akihiko| Senoo, Satoru| Asada, Noboru| Gion, Yuka| Egusa, Yuria| Guo, Lili| Oda, Naohiro| Araki, Kota| Sato, Yasuharu| Toyooka, Shinichi| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
| Keywords | idiopathic pulmonary fibrosis NPY IL-1 beta; bleomycin bronchial epithelial cells |
| Note | Originally Published in:Itano J, Taniguchi A, Senoo S, Asada N, Gion Y, Egusa Y, Guo L, Oda N, Araki K, Sato Y, Toyooka S, Kiura K, Maeda Y, Miyahara N. Neuropeptide Y Antagonizes Development of Pulmonary Fibrosis through IL-1β Inhibition. Am J Respir Cell Mol Biol. 2022 Dec;67(6):654-665. DOI: 10.1165/rcmb.2021-0542OC Copyright © 2022 by the American Thoracic Society The final publication is available at https://doi.org/10.1165/rcmb.2021-0542OC | This full-text will be available in Dec. 2023.| |
| Published Date | 2022-12 |
| Publication Title | American Journal of Respiratory Cell and Molecular Biology |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | American Thoracic Society |
| Start Page | 654 |
| End Page | 665 |
| ISSN | 1044-1549 |
| NCID | AA10707251 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the American Thoracic Society |
| File Version | author |
| PubMed ID | 36122332 |
| DOI | 10.1165/rcmb.2021-0542oc |
| Web of Science KeyUT | 000891796900010 |
| Related Url | isVersionOf https://doi.org/10.1165/rcmb.2021-0542oc |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Kentaro| Okazaki, Mikio| Sakaue, Tomohisa| Kinoshita, Rie| Komoda, Yuhei| Shimizu, Dai| Yamamoto, Haruchika| Tanaka, Shin| Suzawa, Ken| Shien, Kazuhiko| Miyoshi, Kentaroh| Yamamoto, Hiromasa| Ohara, Toshiaki| Sugimoto, Seiichiro| Yamane, Masaomi| Matsukawa, Akihiro| Sakaguchi, Masakiyo| Toyooka, Shinichi| |
| Keywords | ischemia reperfusion injury S100A8/A9 lung transplantation damage-associated molecule patterns |
| Published Date | 2022-11-10 |
| Publication Title | Bioengineering |
| Volume | volume9 |
| Issue | issue11 |
| Publisher | MDPI |
| Start Page | 673 |
| ISSN | 2306-5354 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36354584 |
| DOI | 10.3390/bioengineering9110673 |
| Web of Science KeyUT | 000880897200001 |
| Related Url | isVersionOf https://doi.org/10.3390/bioengineering9110673 |
| JaLCDOI | 10.18926/AMO/64119 |
|---|---|
| FullText URL | 76_6_689.pdf |
| Author | Yamanouchi, Kosho| Kuba, Sayaka| Matsumoto, Megumi| Yano, Hiroshi| Morita, Michi| Sakimura, Chika| Otsubo, Ryota| Hidaka, Masaaki| Nagayasu, Takeshi| Eguchi, Susumu| |
| Abstract | Taxanes are key drugs for patients with breast cancer. A major adverse effect of taxanes is peripheral neuropathy (PN). To investigate the ability of compression therapy using sleeves and stockings to prevent PN due to the taxane docetaxel, we conducted a single-center historical control trial. Patients receiving docetaxel at 75 mg/m2 every 3 weeks for 4 cycles as first-line chemotherapy for breast cancer were eligible. PN was evaluated using the common terminology criteria for adverse events version 4.0. The primary endpoint was the incidence of allgrade PN until 3 weeks after the fourth docetaxel administration. We evaluated 26 patients in the intervention group and compared their data to those collected retrospectively from 52 patients treated with docetaxel without compression. Neither the incidence of all-grade PN until 3 weeks after the fourth docetaxel administration (63.5% in the control group vs. 76.9% in the intervention group, p=0.31) nor that of PN grade ≥ 2 (13.5% vs. 15.4%, p=0.99) differed between the groups. In this study, the efficacy of compression therapy using sleeves and stockings to prevent PN induced by docetaxel was not demonstrated. Further clinical studies including medications or intervention are needed to reduce the incidence and severity of PN induced by chemotherapy. |
| Keywords | breast cancer docetaxel neuropathy compression |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 689 |
| End Page | 694 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549771 |
| Web of Science KeyUT | 000905195100009 |
| JaLCDOI | 10.18926/AMO/64116 |
|---|---|
| FullText URL | 76_6_661.pdf |
| Author | Abe, Yuko| Taira, Naruto| Kashiwabara, Kosuke| Tsurutani, Junji| Kitada, Masahiro| Takahashi, Masato| Kato, Hiroaki| Kikawa, Yuichiro| Sakata, Eiko| Naito, Yoichi| Hasegawa, Yoshie| Saito, Tsuyoshi| Iwasa, Tsutomu| Takashima, Tsutomu| Aihara, Tomohiko| Mukai, Hirofumi| Hara, Fumikata| Shien, Tadahiko| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| Abstract | Chemotherapy-induced peripheral neuropathy (CIPN) is an important clinical challenge that threatens patients’ quality of life. This sub-study of the ABROAD trial investigated the influence of single nucleotide polymorphisms (SNPs) on CIPN, using genotype data from a randomized study to determine the optimal dose of a 3-week-cycle regimen of nab-paclitaxel (q3w nab-PTX) in patients with metastatic breast cancer (MBC). Patients with HER2-negative MBC were randomly assigned to three doses of q3w nab-PTX (SD: 260 mg/m2 vs. MD: 220 mg/m2 vs. LD: 180 mg/m2). Five SNPs (EPHA4-rs17348202, EPHA5-rs7349683, EPHA6-rs301927, LIMK2-rs5749248, and XKR4-rs4737264) were analyzed based on the results of a previous genome-wide association study. Per-allele SNP associations were assessed by a Cox regression to model the cumulative dose of nab-PTX up to the onset of severe or worsening sensory neuropathy. A total of 141 patients were enrolled in the parent study; 91(65%) were included in this sub-study. Worsening of CIPN was significantly greater in the cases with XKR4 AC compared to those with a homozygote AA (HR 1.86, 95%CI: 1.00001−3.46, p=0.049). There was no significant correlation of CIPN with any other SNP. A multivariate analysis showed that the cumulative dose of nab-PTX was most strongly correlated with CIPN (p<0.01). |
| Keywords | metastatic breast cancer taxane-induced peripheral neuropathy chemotherapy-induced peripheral neuropathy nab-paclitaxel single nucleotide polymorphism |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 661 |
| End Page | 671 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549768 |
| Web of Science KeyUT | 000905195100006 |
