result 820 件
| FullText URL | K0006685_abstract_review.pdf K0006685_summary.pdf |
|---|---|
| Author | KUROOKA, Naoko| |
| Published Date | 2022-09-22 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6685号 |
| Granted Date | 2022-09-22 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/64043 |
|---|---|
| FullText URL | 76_5_605.pdf |
| Author | Teraishi, Fuminori| Jikuhara, Atsushi| Ogawa, Ryunosuke| Fujiwara, Toshiyoshi| |
| Abstract | An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation. |
| Keywords | BRAF V600E mutation cecal cancer, MSI-high |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 605 |
| End Page | 608 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352809 |
| Web of Science KeyUT | 000884907100015 |
| JaLCDOI | 10.18926/AMO/64042 |
|---|---|
| FullText URL | 76_5_597.pdf |
| Author | Watanabe, Shiho| Watanabe, Toshiyuki| Yamada, Kiyoshi| Namba, Yuzaburo| Kimata, Yoshihiro| |
| Abstract | Gender affirming surgery (GAS) has important impacts for people with gender incongruence (GI), both physically and socially. As the societal acceptance of gender diversity spreads, the number of individuals with GI who wish to be identified as the gender of their choice is increasing. Indeed, many elderly people who have lived a long time with GI now wish to undergo GAS, but face greater surgical risks due to greater burdens of underlying medical conditions. Generally, vaginoplasty is performed for transwomen; however, this surgery is time-consuming and involves heavy bleeding, and thus, should be avoided in elderly people. A less invasive technique is needed. In this article, we describe a new, less invasive genital feminizing surgical technique for transwomen with reports from two clinical cases. We present this novel technique as a safe, aesthetic, and cost-effective option for gender-affirming surgery for transwomen. |
| Keywords | gender-affirming surgery, vaginoplasty gender incongruence transwomen |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 597 |
| End Page | 603 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352808 |
| Web of Science KeyUT | 000884907100014 |
| JaLCDOI | 10.18926/AMO/64040 |
|---|---|
| FullText URL | 76_5_585.pdf |
| Author | Choshi, Haruki| Watanabe, Mototsugu| Furukawa, Shinichi| Ujike, Hiroyuki| Kataoka, Kazuhiko| |
| Abstract | Pulmonary metastatic resection is a standard therapy for renal cell carcinoma (RCC). Although patients with pulmonary metastases who do not undergo any treatment have poor prognoses, it has been reported that resection for pulmonary metastases yields good clinical outcomes. We investigated the prognoses of the 10 Japanese patients (eight males, two females) who underwent a surgical resection of pulmonary metastasectomy from RCC at our institution between April 1, 2012 and March 31, 2020 and analyzed the prognostic factors. We determined the prognoses and calculated the 5-year overall survival (OS) and disease-free survival (DFS) rates. To identify prognostic factors, we compared the median DFS duration for each factor. Elderly patients (median age, 75.5 years) were more predominant compared to previous studies, and all 10 patients underwent a complete resection. The 5-year DFS rate was 30.5% (95%CI: 0.045-0.63) and the 5-year OS rate was 80% (95%CI: 0.20-0.97). The following factors were associated with better prognosis: female, disease-free interval≥36 months, and metastases size<12 mm. These results indicate that complete resection for pulmonary metastases from RCC resulted in good clinical outcomes, particularly for patients with better prognostic factors. |
| Keywords | renal cell carcinoma pulmonary metastasis complete resection |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 585 |
| End Page | 591 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352806 |
| Web of Science KeyUT | 000884907100012 |
| JaLCDOI | 10.18926/AMO/64039 |
|---|---|
| FullText URL | 76_5_577.pdf |
| Author | Okutani, Yuki| Fujita, Hiroshi| Harada, Hideto| Kataoka, Masanao| Murotani, Yoshiki| Shimizu, Yu| |
| Abstract | The prevalence of preoperative deep vein thrombosis (DVT) has been reported to be relatively high in patients undergoing total hip arthroplasty. We investigated the prevalence of DVT, the association between hip function and preoperative DVT, and the effect of a history of surgery in patients who underwent primary total hip arthroplasty. We retrospectively analyzed the cases of the patients who underwent primary total hip arthroplasty between April 2013 and February 2020 at our institution. We evaluated the prevalence of preoperative DVT based on the results of the patients’ ultrasound screening. We performed univariate and multivariate analyses to investigate the association between the incidence of DVT and patient factors including age, sex, hip function, medical histories, and American Society of Anesthesiologists Physical Status classification. We analyzed 451 patients (494 hips). The prevalence of DVT was 14.2% (64 patients). The multivariate analysis demonstrated that increased age was an independent significant risk factor for DVT. The prevalence of preoperative DVT was relatively high among patients who underwent primary total hip arthroplasty. Preoperative DVT tended to be more prevalent in older patients. Hip function was not associated with the incidence of DVT. |
| Keywords | total hip arthroplasty deep vein thrombosis hip function ultrasound screening |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 577 |
| End Page | 584 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352805 |
| Web of Science KeyUT | 000884907100011 |
| JaLCDOI | 10.18926/AMO/64032 |
|---|---|
| FullText URL | 76_5_519.pdf |
| Author | Ishioka, Yoko| Yamashita, Hiroyuki| Hamaguchi, Kinya| Kuwahara, Yoshitaka| Nakamura, Kaoru| Nakatsuka, Mikiya| |
| Abstract | To examine the outcome of gestational blood pressure and birth weight in women with normal pre-pregnancy BMI (18.5-25 kg/m2) who are at the lower and upper limits of this range, i.e., slightly underweight or slightly overweight. Overall, 2,038 Japanese women with low -risk who had delivered during January 2014–December 2016 were classified according to their pre-pregnancy BMI: underweight (< 18.5 kg/m2), slightly underweight (18.5≤BMI<21 kg/m2), normal (21≤BMI<23 kg/m2), slightly overweight (23≤BMI<25 kg/m2) and overweight (≤ 25 kg/m2). Their blood pressure during each trimester and birth weight was evaluated. The slightly overweight group showed a significantly higher blood pressure than the underweight and slightly underweight groups. Birth weight was lower in the slightly underweight than in the slightly overweight group (p<0.01). The incidence rate of “heavy for dates” (HFD) infants was significantly higher in the slightly overweight and overweight groups than in the other groups (p<0.05 and p<0.01, respectively). Weight gain of < 7 kg significantly increased the rate of “light for dates” (LFD) infants, while a weight gain of ≥13 kg significantly increased the rate of HFD infants (p<0.05 and p<0.01, respectively). Blood pressure during pregnancy was ssociated with pre-pregnancy BMI. The birth weight of infants of low-risk pregnant women is affected by both pre-pregnancy BMI and gestational weight gain. |
| Keywords | birth weight blood pressure normal body weight pregnancy pre-pregnancy BMI |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 519 |
| End Page | 526 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352798 |
| Web of Science KeyUT | 000884907100004 |
| JaLCDOI | 10.18926/AMO/64025 |
|---|---|
| FullText URL | 76_5_503.pdf |
| Author | Ogawa, Hirohito| Honda, Tomoyuki| |
| Abstract | Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. |
| Keywords | EVE nrEVE bornavirus filovirus antiviral |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 503 |
| End Page | 510 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352796 |
| Web of Science KeyUT | 000884907100002 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| FullText URL | 76_5_489.pdf |
| Author | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| Keywords | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 489 |
| End Page | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
| FullText URL | fulltext20221102-1.pdf |
|---|---|
| Author | Miyoshi, Shin-ichi| Toko, Norie| Dodo, Tetsuya| Nanko, Ayako| Mizuno, Tamaki| |
| Keywords | Vibrio mimicus Serine protease Hemolysin Maturation |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11274-022-03436-9| This fulltext is available in Oct. 2023.| |
| Published Date | 2022-10-22 |
| Publication Title | World Journal of Microbiology and Biotechnology |
| Volume | volume38 |
| Issue | issue12 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 241 |
| ISSN | 0959-3993 |
| NCID | AA10811107 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s), under exclusive licence to Springer Nature B.V. 2022 |
| File Version | author |
| PubMed ID | 36271946 |
| DOI | 10.1007/s11274-022-03436-9 |
| Web of Science KeyUT | 000871180800001 |
| Related Url | isVersionOf https://doi.org/10.1007/s11274-022-03436-9 |
| FullText URL | fulltext20221004-1.pdf Figure_1_20221004-1.jpg Figure_2A_20221004-1.jpg Figure_2B_20221004-1.jpg Figure_2C_20221004-1.jpg Figure_2D_20221004-1.jpg Figure_3_20221004-1.jpg Figure_4_20221004-1.jpg |
|---|---|
| Author | Matsumoto, Kazuyuki| Kato, Hironari| Fujii, Masakuni| Ueki, Toru| Saragai, Yosuke| Tsugeno, Hirofumi| Mannami, Tomohiko| Okada, Hiroyuki| |
| Keywords | benign biliary stricture fully-covered self-expandable metal stent intraductal placement refractory biliary stricture |
| Note | This is the peer reviewed version of the following article: [Matsumoto, K, Kato, H, Fujii, M, Ueki, T, Saragai, Y, Tsugeno, H, Efficacy of intraductal placement of nonflared fully-covered metal stent for refractory perihilar benign biliary strictures: A multicenter prospective study with long-term observation. J Hepatobiliary Pancreat Sci. 2022; 29: 1300– 1307. https://doi.org/10.1002/jhbp.1188], which has been published in final form at [https://doi.org/10.1002/jhbp.1188]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext is available in June 2023.| |
| Published Date | 2022-06-03 |
| Publication Title | Journal of Hepato-Biliary-Pancreatic Sciences |
| Volume | volume29 |
| Issue | issue12 |
| Publisher | Wiley |
| Start Page | 1300 |
| End Page | 1307 |
| ISSN | 1868-6974 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Japanese Society of Hepato-Biliary-Pancreatic Surgery. |
| File Version | author |
| PubMed ID | 35657019 |
| DOI | 10.1002/jhbp.1188 |
| Web of Science KeyUT | 000814050800001 |
| Related Url | isVersionOf https://doi.org/10.1002/jhbp.1188 |
| JaLCDOI | 10.18926/AMO/63908 |
|---|---|
| FullText URL | 76_4_479.pdf |
| Author | Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi| |
| Abstract | A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance. |
| Keywords | hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 479 |
| End Page | 483 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123164 |
| Web of Science KeyUT | 000882167300012 |
| JaLCDOI | 10.18926/AMO/63901 |
|---|---|
| FullText URL | 76_4_423.pdf |
| Author | Takahashi, Satoshi| Kushibe, Takuya| Akezaki, Yoshiteru| Horiike, Norio| |
| Abstract | We compared the effects of an exercise intervention with that of exercise combined with nutrition therapy in patients with possible malnutrition and sarcopenia admitted to a recovery rehabilitation ward, and we examined the differences in the patients’ physical function and activities of daily living (ADLs). There were 16 patients in the Exercise group with exercise therapy and ADL exercises, and 14 patients in the Combined intervention group with exercise therapy, ADL exercises, and nutrition therapy. The survey items were body weight, body mass index, grip strength, lower-leg circumference, gait speed, and ADLs, each of which was measured at the baseline and at 2 weeks, 4 weeks, and at discharge. Significant improvements in grip strength were observed in the Combined intervention group as follows: at 4 weeks>at 2 weeks (p<0.05), and at discharge>baseline and 2 weeks (p<0.05). There were no significant changes in the Exercise group, and an interaction was recognized in both groups. Comprehensive rehabilitation including nutrition therapy is necessary for patients with possible malnutrition and/or sarcopenia, as our results indicate that nutrition therapy in addition to exercise therapy has the effect of promoting improvements of physical function in such patients. |
| Keywords | sarcopenia rehabilitation exercise therapy nutrition therapy grip strength |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 423 |
| End Page | 428 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123157 |
| Web of Science KeyUT | 000882167300008 |
| JaLCDOI | 10.18926/AMO/63894 |
|---|---|
| FullText URL | 76_4_399.pdf |
| Author | Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| Abstract | According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67. |
| Keywords | breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 399 |
| End Page | 408 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123154 |
| Web of Science KeyUT | 000882167300005 |
| JaLCDOI | 10.18926/AMO/63892 |
|---|---|
| FullText URL | 76_4_385.pdf |
| Author | Manabe, Tomotaka| Miyake, Keisuke| Kaji, Yoshio| Ninomiya, Kento| Fujita, Chiaki| Tanaka, Shouichi| Morita, Shin| Tamiya, Takashi| Yamamoto, Tetsuji| |
| Abstract | The relationship between perioperative clinical course variables and postoperative length of hospital stay (LOS) in patients undergoing primary intracranial meningioma resection has not been fully elucidated. We therefore aimed to identify the perioperative clinical course variables that predict postoperative LOS in such patients. We retrospectively collected data concerning demographics, tumor characteristics, and perioperative clinical course variables in 76 patients who underwent primary intracranial meningioma resection between January 2010 and December 2019, and tested for associations with postoperative LOS. Univariate analyses showed that younger age, fewer days to postoperative initiation of standing/walking, preoperative independence in activities of daily living (ADL), and ADL independence one week after surgery were associated with shorter postoperative LOS. Multiple regression analyses with these factors identified that days to stand/walk initiation and ADL independence one week after surgery were associated with postoperative LOS. Based on these results, we conclude that rehabilitation programs that promote early mobilization and the early acquisition of independence may reduce postoperative LOS in patients who undergo primary intracranial meningioma resection. |
| Keywords | early mobilization functional independence perioperative clinical course length of hospital stay meningioma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 385 |
| End Page | 390 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123152 |
| Web of Science KeyUT | 000882167300004 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Akil, Caner| Tran, Linh T.| Orhant-Prioux, Magali| Baskaran, Yohendran| Senju, Yosuke| Takeda, Shuichi| Chotchuang, Phatcharin| Muengsaen, Duangkamon| Schulte, Albert| Manser, Edward| Blanchoin, Laurent| Robinson, Robert C.| |
| Published Date | 2022-08-31 |
| Publication Title | Communications Biology |
| Volume | volume5 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 890 |
| ISSN | 2399-3642 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 36045281 |
| DOI | 10.1038/s42003-022-03783-1 |
| Web of Science KeyUT | 000849355300002 |
| Related Url | isVersionOf https://doi.org/10.1038/s42003-022-03783-1 |
| JaLCDOI | 10.18926/AMO/63887 |
|---|---|
| FullText URL | 76_4_359.pdf |
| Author | Hiramatsu-Asano, Sumie| Wada, Jun| |
| Abstract | Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE. |
| Keywords | systemic lupus erythematosus miRNA miRNA targeting therapy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 371 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123150 |
| Web of Science KeyUT | 000882167300002 |
| FullText URL | ManuscriptFinal20220908-3.pdf Table1_20220908-3.pdf Fig20220908-3.pdf Supplementary20220908-3.pdf |
|---|---|
| Author | Uchiyama, Jumpei| Osumi, Takafumi| Mizukami, Keijiro| Fukuyama, Tomoki| Shima, Ayaka| Unno, Asaka| Takemura‐Uchiyama, Iyo| Une, Yumi| Murakami, Hironobu| Sakaguchi, Masahiro| |
| Keywords | oral gut microbiota atopic dermatitis Shiba Inu dog colony canine |
| Note | This is a pre-copyedited, author-produced version of an article accepted for publication in [Letters in Applied Microbiology] following peer review. The version of record [J. Uchiyama, T. Osumi, K. Mizukami, T. Fukuyama, A. Shima, A. Unno, I. Takemura‐Uchiyama, Y. Une, H. Murakami, M. Sakaguchi, Characterization of the oral and faecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony, Letters in Applied Microbiology, Volume 75, Issue 6, 1 December 2022, Pages 1607–1616, https://doi.org/10.1111/lam.13828] is available online at: [https://doi.org/10.1111/lam.13828].| This fulltext is available in Dec. 2023.| |
| Published Date | 2022-12-01 |
| Publication Title | Letters in Applied Microbiology |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Oxford University Press |
| Start Page | 1607 |
| End Page | 1616 |
| ISSN | 0266-8254 |
| NCID | AA10462245 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Society for Applied Microbiology |
| File Version | author |
| PubMed ID | 36067033 |
| DOI | 10.1111/lam.13828 |
| Web of Science KeyUT | 000853313000001 |
| Related Url | isVersionOf https://doi.org/10.1111/lam.13828 |
| FullText URL | fulltext20220830-4.pdf CMT2Z Figure NCN revise.tif CMT2Z Table NCN revise.tif |
|---|---|
| Author | Nomura, Emi| Tadokoro, Koh| Sasaki, Ryo| Nakata, Yumi| Nakano, Yumiko| Yunoki, Taijun| Takemoto, Mami| Morihara, Ryuta| Ando, Masahiro| Takashima, Hiroshi| Yamashita, Toru| |
| Keywords | Charcot-Marie-Tooth disease type 2Z MORC2 retinitis pigmentosa |
| Note | This is the peer reviewed version of the following article: [Nomura, E, Tadokoro, K, Sasaki, R, et al. Japanese case of Charcot–Marie–Tooth disease type 2Z with severe retinitis pigmentosa. Neurol Clin Neurosci. 2022; 10: 266-268. doi: 10.1111/ncn3.12660], which has been published in final form at [https://doi.org/10.1111/ncn3.12660]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| Published Date | 2022-08-15 |
| Publication Title | Neurology and Clinical Neuroscience |
| Volume | volume10 |
| Issue | issue5 |
| Publisher | Wiley |
| Start Page | 266 |
| End Page | 268 |
| ISSN | 2049-4173 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd. |
| File Version | author |
| DOI | 10.1111/ncn3.12660 |
| Web of Science KeyUT | 000843400700001 |
| Related Url | isVersionOf https://doi.org/10.1111/ncn3.12660 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Meguri, Yusuke| Asano, Takeru| Yoshioka, Takanori| Iwamoto, Miki| Ikegawa, Shuntaro| Sugiura, Hiroyuki| Kishi, Yuriko| Nakamura, Makoto| Sando, Yasuhisa| Kondo, Takumi| Sumii, Yuichi| Maeda, Yoshinobu| Matsuoka, Ken-Ichi| |
| Keywords | regulatory T cell low-dose interleukin-2 therapy graft-versus-host disease graft-versus-leukemia effect transplantation tolerance |
| Published Date | 2022-08-02 |
| Publication Title | Frontiers In Immunology |
| Volume | volume13 |
| Publisher | Frontiers Media |
| Start Page | 891925 |
| ISSN | 1664-3224 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Meguri, Asano, Yoshioka, Iwamoto, Ikegawa, Sugiura, Kishi, Nakamura, Sando, Kondo, Sumii, Maeda and Matsuoka. |
| File Version | publisher |
| PubMed ID | 35983059 |
| DOI | 10.3389/fimmu.2022.891925 |
| Web of Science KeyUT | 000844642000001 |
| Related Url | isVersionOf https://doi.org/10.3389/fimmu.2022.891925 |
| FullText URL | sac59draft.pdf |
|---|---|
| Author | Matsuo, Hirotoshi| Fukushima, Hiroko| Kurokawa, Shinpei| Kawano, Eri| Okamoto, Takashi| Motose, Hiroyasu| Takahashi, Taku| |
| Keywords | Arabidopsis JMJD6 mRNA stability thermospermine xylem development |
| Note | This is the peer reviewed version of the following article: [Matsuo, H., Fukushima, H., Kurokawa, S., Kawano, E., Okamoto, T., Motose, H. and Takahashi, T. (2022), Loss of function of an Arabidopsis homologue of JMJD6 suppresses the dwarf phenotype of acl5, a mutant defective in thermospermine biosynthesis. FEBS Lett.], which has been published in final form at [https://doi.org/10.1002/1873-3468.14470]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| Published Date | 2022-08-12 |
| Publication Title | FEBS Letters |
| Volume | volume596 |
| Issue | issue23 |
| Publisher | Wiley |
| Start Page | 3005 |
| End Page | 3014 |
| ISSN | 0014-5793 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Federation of European Biochemical Societies. |
| File Version | author |
| PubMed ID | 35962471 |
| DOI | 10.1002/1873-3468.14470 |
| Web of Science KeyUT | 000839973700001 |
| Related Url | isVersionOf https://doi.org/10.1002/1873-3468.14470 |
