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FullText URL fulltext20211011-1.pdf figures20211011-1.pdf
Author Uchida, Tetsuya| Onishi, Yukihisa| Goto, Atsu|
Keywords rigid polymer network heat resistance proton phosphoric acid conductivity
Note This is the peer reviewed version of the following article: [Uchida, T, Onishi, Y, Goto, A. Preparation of highly porous heat-resistant polybenzoxazole network films and their electrical conductivities. Polym Adv Technol. 2021; 1- 7. doi:10.1002/pat.5494], which has been published in final form at [https://doi.org/10.1002/pat.5494]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-ArchivedVersions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wileyor by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked toWiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof bythird parties from platforms, services and websites other than Wiley Online Library must be prohibited.
This fulltext is available in Sep. 2022.|
Published Date 2021-9-9
Publication Title Polymers for Advanced Technologies
Publisher Wiley
Start Page 1
ISSN 1042-7147
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1002/pat.5494
Web of Science KeyUT 000695527000001
Related Url isVersionOf https://doi.org/10.1002/pat.5494
FullText URL fulltext20211006-2a.pdf
Author Kamada, Yasuhiko| Kusumoto, Rie| Kashino, Chiaki| Kubo, Kotaro| Mitsui, Takashi| Masuyama, Hisashi|
Keywords double cross plasty genital chronic graft-versus-host disease hematocolpos hematopoietic stem cell transplantation vaginal reconstruction
Note This is the peer reviewed version of the following article: [Kamada, Y., Kusumoto, R., Kashino, C., Kubo, K., Mitsui, T., & Masuyama, H. (2021). Surgically treated genital chronic graft‐versus‐host disease in women: A report of three cases. Journal of Obstetrics and Gynaecology Research.], which has been published in final form at [https://doi.org/10.1111/jog.15005]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-ArchivedVersions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wileyor by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked toWiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof bythird parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
Published Date 2021-09-05
Publication Title Journal of Obstetrics and Gynaecology Research
Volume volume47
Issue issue11
Publisher Wiley
Start Page 4122
End Page 4126
ISSN 1341-8076
NCID AA11082002
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Japan Society of Obstetrics and Gynecology
File Version author
PubMed ID 34482585
DOI 10.1111/jog.15005
Web of Science KeyUT 000697443000001
Related Url isVersionOf https://doi.org/10.1111/jog.15005
FullText URL fulltext.pdf
Author Sato, Ryoichi| Kodera, Yuta| Ali, Md. Arshad| Kusaka, Takuya| Nogami, Yasuyuki| Morelos-Zaragoza, Robert H.|
Keywords entropy field programmable gate array true random number generator period ring oscillator stomatic process state transition XOR gate
Published Date 2021-09-05
Publication Title Entropy
Volume volume23
Issue issue9
Publisher MDPI
Start Page 1168
ISSN 1099-4300
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34573793
DOI 10.3390/e23091168
Web of Science KeyUT 000699789000001
Related Url isVersionOf https://doi.org/10.3390/e23091168
FullText URL fulltext.pdf
Author Mansour, Hager| Hassan, Ghmkin| Afify, Said M.| Yan, Ting| Seno, Akimasa| Seno, Masaharu|
Keywords metastasis cancer stem cells transplantation surgery
Published Date 2020-08-21
Publication Title Methods and Protocols
Volume volume3
Issue issue3
Publisher MDPI
Start Page 60
ISSN 2409-9279
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32825540
DOI 10.3390/mps3030060
Web of Science KeyUT 000698975500015
Related Url isVersionOf https://doi.org/10.3390/mps3030060
FullText URL fulltext20210928-1.pdf
Author Umeda, Yuzo| Mitsuhashi, Toshiharu| Kojima, Toru| Satoh, Daisuke| Sui, Kenta| Endo, Yoshikatsu| Inagaki, Masaru| Oishi, Masahiro| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords intrahepatic cholangiocarcinoma lymph node excision multicenter study propensity score retrospective studies
Note This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.|
Published Date 2021-9-16
Publication Title Journal of Hepato-Biliary-Pancreatic Sciences
Publisher Wiley
Start Page 1
End Page 13
ISSN 1868-6974
NCID AA12507209
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors. Journal of Hepato-Biliary-Pancreatic Sciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Hepato-Biliary-Pancreatic Surgery.
File Version publisher
PubMed ID 34473411
DOI 10.1002/jhbp.1038
Web of Science KeyUT 000696321700001
Related Url isVersionOf https://doi.org/10.1002/jhbp.1038
FullText URL fulltext.pdf
Author Matsumoto, Ryohtaroh| Takahashi, Daisuke| Watanabe, Masaki| Nakatani, Shunsuke| Takamura, Yuta| Kurosaki, Yuji| Kakuta, Hiroki| Hase, Koji|
Keywords RXR NEt-3IB inflammatory bowel disease colitis Th1 cells
Published Date 2021-08-12
Publication Title Frontiers In Pharmacology
Volume volume12
Publisher Frontiers Media SA
Start Page 715752
ISSN 1663-9812
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Matsumoto, Takahashi, Watanabe, Nakatani, Takamura,Kurosaki, Kakuta and Hase.
File Version publisher
PubMed ID 34475823
DOI 10.3389/fphar.2021.715752
Web of Science KeyUT 000693889000001
Related Url isVersionOf https://doi.org/10.3389/fphar.2021.715752
JaLCDOI 10.18926/AMO/62397
FullText URL 75_4_455.pdf
Author Muraoka, Sosuke| Yamane, Kentaro| Misawa, Haruo| Takigawa, Tomoyuki| Tetsunaga, Tomoko| Oda, Yoshiaki| Nakanishi, Kazuo| Ozaki, Toshifumi| Tanaka, Takehiro|
Abstract The intraoperative pathological diagnosis (IPD) plays an important role in determining the optimal surgical treatment for spinal cord tumors. The final pathological diagnosis (FPD) is sometimes different from the IPD. Here, we sought to identify the accuracy of the IPD of spinal cord tumors compared to the FPD. We retrospec-tively analyzed the cases of 108 patients with spinal cord tumors treated surgically in our institute; the IPD, FPD, mismatched cases, and concordance rate between the IPD and FPD were investigated. Five cases involved a mismatch between the IPD and FPD. The overall concordance rate was 95.4%, with 90.9% for extra-dural lesions, 98.5% for intradural extramedullary lesions, 84.2% for intramedullary lesions, and 100% for dumbbell-type tumors. The concordance rate of intramedullary lesions tended to be lower than that of other lesions (p = 0.096). A lower concordance rate was revealed for intramedullary lesions compared to the other lesions. Despite the IPD clearly remaining a valuable tool during operative procedures, surgeons should recog-nize the limitations of IPDs and make comprehensive decisions about surgical treatments.
Keywords spinal cord tumor intraoperative pathological diagnosis final pathological diagnosis concordance rate
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-08
Volume volume75
Issue issue4
Publisher Okayama University Medical School
Start Page 455
End Page 460
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34511612
Web of Science KeyUT 000697944600007
NAID 120007146040
JaLCDOI 10.18926/AMO/62380
FullText URL 75_4_423.pdf
Author Takihira, Shota| Furumatsu, Takayuki| Okazaki, Yuki| Hiranaka, Takaaki| Kintaka, Keisuke| Kodama, Yuya| Kamatsuki, Yusuke| Miyazawa, Shinichi| Ozaki, Toshifumi |
Abstract The treatment of medial meniscus posterior root tears (MMPRTs) has evolved to include a variety of repair strategies. This study investigated the location of the articular cartilage degeneration during second-look arthroscopy after transtibial pullout repair with a modified Mason-Allen suture using FasT-Fix (F-MMA) in 22 patients with MMPRTs. Second-look arthroscopy was performed approximately 1 year postoperatively to eval-uate the healing status of the medial meniscus (MM). Articular cartilage degeneration was assessed using the International Cartilage Repair Society grade at primary surgery and again at second-look arthroscopy. Articular surfaces of the medial/lateral femoral condyles, the medial/lateral tibial plateaus, the patella and the trochlea were divided into several subcompartments (MF 1-9, LF 1-9, MT 1-5, LT 1-5, P 1-9, T 1-3). Clinical evaluations used the Japanese Knee Injury and Osteoarthritis Outcome, Lysholm, and International Knee Documentation Committee scores. Second-look arthroscopic findings showed complete healing of the MM posterior root in all patients. Significant differences between pullout repair and second-look arthroscopy were observed for MF 2 and 4, LF 7, and P 7. All clinical outcomes were improved. Our results indicate that this technique improves clinical outcomes postoperatively and may prevent the progression of cartilage degenera-tion on the loading surface of the medial knee compartment.
Keywords articular cartilage medial meniscus modified Mason-Allen suture technique posterior root tear second-look arthroscopy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-08
Volume volume75
Issue issue4
Publisher Okayama University Medical School
Start Page 423
End Page 430
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34511608
Web of Science KeyUT 000697944600003
NAID 120007146061
JaLCDOI 10.18926/AMO/62378
FullText URL 75_4_403.pdf
Author Matoba, Ryo| Morizane, Yuki|
Abstract Epiretinal membrane (ERM) is a common retinal disease characterized by cellular proliferation and metaplasia that lead to the formation of a pathological fibrocellular membrane immediately superjacent to the inner retinal surface. The vast majority of ERMs are considered idiopathic. However, ERM formation can result from various primary intraocular diseases, including retinal breaks and detachment, retinal vascular diseases, and vitreoretinal inflammatory conditions. Although ERMs are generally asymptomatic or cause mild metamorphopsia and/or a modest decrease in visual acuity, some can cause severe macular distortion and macular edema, resulting in significantly impaired function. Surgical removal of ERM is the only treatment, and improvements in vitrectomy systems have enabled less invasive treatment. However, there are currently no standardized criteria for ERM surgery, and the indications for surgery are determined from the patient’s subjective symptoms. Another problem with ERM surgery is that not all patients show satisfactory postoperative recovery of visual function. Thus, further research is needed to determine the criteria for ERM surgery and methods to improve the postoperative prognosis.
Keywords epiretinal membrane vitrectomy optical coherence tomography internal limiting membrane lamellar macular hole
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2021-08
Volume volume75
Issue issue4
Publisher Okayama University Medical School
Start Page 403
End Page 413
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34511606
Web of Science KeyUT 000697944600001
NAID 120007146059
FullText URL fulltext20210824-2.pdf
Author Yang, Jiajia| Huber, Laurentius| Yu, Yinghua| Bandettini, Peter A.|
Keywords Cortical layers Laminar fMRI Cortical circuit models Human brain function Cognition
Note This is an open access article under the CC BY-NC-ND license.|
Published Date 2021-9
Publication Title Neuroscience & Biobehavioral Reviews
Volume volume128
Publisher Elsevier BV
Start Page 467
End Page 478
ISSN 0149-7634
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Author(s).
File Version publisher
PubMed ID 34245758
DOI 10.1016/j.neubiorev.2021.07.005
Web of Science KeyUT 000679529700001
Related Url isVersionOf https://doi.org/10.1016/j.neubiorev.2021.07.005
FullText URL fulltext20210811-1.pdf
Author Miyatake, Takahisa|
Keywords Zeugodacus cucurbitae mass-rearing mating melon fly quality 16 control sterile insect technique SIT Diptera Tephritidae correlated responses
Note This is the peer reviewed version of the following article: [Miyatake, T. (2021), Selection for age at reproduction changes pre-mating period and mating frequency in Zeugodacus cucurbitae: impacts on insect quality control. Entomol Exp Appl, 169: 959-965.], which has been published in final form at [https://doi.org/10.1111/eea.13084]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
Published Date 2021-7-5
Publication Title Entomologia Experimentalis et Applicata
Volume volume169
Publisher Wiley
Start Page 959
End Page 965
ISSN 0013-8703
NCID AA00636634
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Netherlands Entomological Society Entomologia Experimentalis et Applicata 1–7, 2021
File Version author
DOI 10.1111/eea.13084
Web of Science KeyUT 000678839700001
Related Url isVersionOf https://doi.org/10.1111/eea.13084
FullText URL fulltext20210721-3.pdf
Author Doi, Toshihisa|
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10209-021-00827-x|
Published Date 2021-7-8
Publication Title Universal Access in the Information Society
Volume volume22
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 111
End Page 119
ISSN 1615-5289
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1007/s10209-021-00827-x
Web of Science KeyUT 000670833700001
Related Url isVersionOf https://doi.org/10.1007/s10209-021-00827-x
FullText URL fulltext.pdf
Author Tahjib-Ul-Arif, Md.| Zahan, Mst, Ishrat| Karim, Md. Masudul| Imran, Shahin| Hunter, Charles T.| Islam, Md. Saiful| Mia, Md. Ashik| Hannan, Md. Abdul| Rhaman, Mohammad Saidur| Hossain, Md. Afzal| Brestic, Marian| Skalicky, Milan| Murata, Yoshiyuki|
Keywords citrate heavy metal stress drought stress antioxidant reactive oxygen species salinity aluminum toxicity
Published Date 2021-07-05
Publication Title International Journal of Molecular Sciences
Volume volume22
Issue issue13
Publisher MDPI
Start Page 7235
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
DOI 10.3390/ijms22137235
Web of Science KeyUT 000671283500001
Related Url isVersionOf https://doi.org/10.3390/ijms22137235
FullText URL fulltext.pdf
Author Nakamura, Makoto| Meguri, Yusuke| Ikegawa, Shuntaro| Kondo, Takumi| Sumii, Yuichi| Fukumi, Takuya| Iwamoto, Miki| Sando, Yasuhisa| Sugiura, Hiroyuki| Asada, Noboru| Ennishi, Daisuke| Tomida, Shuta| Fukuda-Kawaguchi, Emi| Ishii, Yasuyuki| Maeda, Yoshinobu| Matsuoka, Ken-Ichi|
Published Date 2021-06-23
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
Start Page 13125
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 34162921
DOI 10.1038/s41598-021-92526-z
Web of Science KeyUT 000669995600012
Related Url isVersionOf https://doi.org/10.1038/s41598-021-92526-z
FullText URL fulltext.pdf
Author Sakaida, Kyosuke| Omori, Kazuhiro| Nakayama, Masaaki| Mandai, Hiroki| Nakagawa, Saki| Sako, Hidefumi| Kamei, Chiaki| Yamamoto, Satoshi| Kobayashi, Hiroya| Ishii, Satoki| Ono, Mitsuaki| Ibaragi, Soichiro| Yamashiro, Keisuke| Yamamoto, Tadashi| Suga, Seiji| Takashiba, Shogo|
Keywords (+)-terrein ovariectomy osteoporosis RANKL PKC
Published Date 2021-06-08
Publication Title Frontiers In Pharmacology
Volume volume12
Publisher Frontiers Media SA
Start Page 674366
ISSN 1663-9812
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Sakaida, Omori, Nakayama, Mandai, Nakagawa, Sako, Kamei, Yamamoto, Kobayashi, Ishii, Ono, Ibaragi, Yamashiro, Yamamoto, Suga and Takashiba.
File Version publisher
PubMed ID 34168561
DOI 10.3389/fphar.2021.674366
Web of Science KeyUT 000664090900001
Related Url isVersionOf https://doi.org/10.3389/fphar.2021.674366
FullText URL fulltext.pdf
Author Kageyama, Misaki| Hagiya, Hideharu| Ueda, Yasutaka| Ohtani, Katsuki| Fukumori, Yasuo| Inoue, Norimitsu| Wakamiya, Nobutaka| Yoneda, Nanoka| Kimura, Keigo| Nagasawa, Motonori| Nakagami, Futoshi| Nishi, Isao| Sugimoto, Ken| Rakugi, Hiromi|
Keywords complement addition test complement deficiency disseminated gonococcal infection genome analysis Neisseria gonorrhoeae sexually transmitted infection
Published Date 2021-04-02
Publication Title Medicine
Volume volume100
Issue issue13
Publisher LIPPINCOTT WILLIAMS & WILKINS
Start Page e25265
ISSN 0025-7974
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 the Author(s).
File Version publisher
PubMed ID 33787610
NAID 120007098535
DOI 10.1097/MD.0000000000025265
Web of Science KeyUT 000658960700045
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000025265
JaLCDOI 10.18926/AMO/62233
FullText URL 75_3_373.pdf
Author Yaylali, Guzin F.| Dedeoglu, Ozen | Topsakal, Senay| Herek, Duygu| Senol, Hande|
Abstract Osteocalcin (OC) is inversely related to body fat distribution and fasting glucose levels. We sought to observe the effect of OC on fat distribution and subclinical atherosclerosis as measured by carotid intima-media thickness (CIMT) in premenopausal obese women. In this prospective observational study, totally, 73 premenopausal obese women (aged 17-55 years) and 53 healthy women (aged 20-50 years) with normal weight were included as controls. Anthropometric measurements, total fat and fat ratio, insulin, fasting blood glucose, and OC levels were estimated. Ultrasonography was used to assess fat distribution, and fat thickness was measured in 4 regions. Subcutaneous fat (SCF), visceral fat (VF), and preperitoneal fat (PPF) thicknesses were considerably higher in obese subjects (p<0.01) than healthy controls, while OC levels were significantly lower. No correlation was observed between OC levels and SCF, VF, or PPF. In a multiple regression analysis, OC was significantly positively associated with SCF (p=0.04, Beta=0.284). No associations were observed between OC levels and VF, PPF, or CIMT. A significant association was observed between parathyroid hormone (PTH) and VF (p=0.021, Beta=0.284), and vitamin D levels were inversely associated with VF (p=0.002, r=−0.366). OC levels were lower in premenopausal obese women than normal-weight healthy controls, but OC exhibited no correlation with VF or PPF, and only a weak positive association with SCF. Additionally, VF was positively correlated with PTH and inversely correlated with vitamin D. These results suggest that OC may be an early indicator of lipid accumulation in te subcutaneous area and development of atherosclerosis.
Keywords body fat composition carotid intima-media thickness obesity osteocalcin premenopausal women
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-06
Volume volume75
Issue issue3
Publisher Okayama University Medical School
Start Page 373
End Page 379
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34176942
Web of Science KeyUT 000667147700013
NAID 120007089830
JaLCDOI 10.18926/AMO/62230
FullText URL 75_3_351.pdf
Author Mitamura, Katsuya| Norikane, Takashi| Yamamoto, Yuka| Ihara-Nishishita, Ayumi| Kobata, Takuya| Fujimoto, Kengo| Takami, Yasukage| Kudomi, Nobuyuki| Hoshikawa, Hiroshi| Nishiyama, Yoshihiro|
Abstract We assessed the role of 18F-FDG PET/CT texture indices for the differentiation of squamous cell carcinoma (SCC) and non-Hodgkin’s lymphoma (NHL) in the oropharynx. 18F-FDG PET/CT data for 27 patients with SCC and 25 patients with NHL in the oropharynx were investigated. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and six texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low gray-level zone emphasis [LGZE], and high graylevel zone emphasis [HGZE]) were derived from PET images. PET/CT parameters of the SCC patients were compared with those of the NHL patients. The diagnostic accuracy of the indices for differentiating SCC from NHL was calculated by a receiver operating characteristic curve analysis. 18F-FDG uptake in the oropharynx was observed in all of the patients. The SUVmax, MTV, and TLG did not differ significantly between the SCC and NHL groups, but two of the six texture indices (LGZE [p=0.004] and HGZE [p=0.03]) showed significant differences between the groups. LGZE was the best discriminative index for the differentiation of SCC and NHL (55.6% sensitivity, 88.0% specificity). The LGZE and HGZE texture indices derived from 18F-FDG PET/CT images may be useful in differentiating SCC and NHL in the oropharynx.
Keywords 18F-FDG PET/CT oropharyngeal squamous cell carcinoma malignant lymphoma texture
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-06
Volume volume75
Issue issue3
Publisher Okayama University Medical School
Start Page 351
End Page 356
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34176939
Web of Science KeyUT 000667147700010
NAID 120007089827
JaLCDOI 10.18926/AMO/62228
FullText URL 75_3_335.pdf
Author Chikuie, Nobuyuki| Hamamoto, Takao| Ueda, Tsutomu| Taruya, Takayuki| Kono, Takashi| Furuie, Hiromi| Ishino, Takashi| Takeno, Sachio|
Abstract Recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC) has a poor prognosis. Although nivolumab is approved in Japan for treating R/MHNSCC, the response rate is low. Therefore, identifying pretreatment prognostic factors is necessary. This study assessed the utility of the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS) as biomarkers of response to nivolumab. We retrospectively collected the data of 56 R/MHNSCC patients treated with nivolumab between May 2017 and December 2019. The Kaplan–Meier method and log-rank test were used to estimate overall survival (OS) and progression-free survival (PFS), and multivariate Cox hazard regression analysis was used to identify independent predictors of survival. Patients with a low pretreatment NLR had prolonged OS, and patients with a low pretreatment GPS had increased OS and PFS. A performance score (PS) of 0-1, development of immune-related adverse events, and GPS of 0-1 were significantly associated with OS in multivariate analysis. In summary, baseline pretreatment NLR and GPS are independently associated with OS in R/MHNSCC patients treated with nivolumab. Administration of nivolumab while maintaining the PS reflects a immune status of the host and leads to a good OS.
Keywords neutrophil-to-lymphocyte ratio nivolumab Glasgow Prognostic Score recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC)
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-06
Volume volume75
Issue issue3
Publisher Okayama University Medical School
Start Page 335
End Page 343
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34176937
Web of Science KeyUT 000667147700008
NAID 120007089825
JaLCDOI 10.18926/AMO/62226
FullText URL 75_3_315.pdf
Author Wada, Riho| Fujiwara, Masaki| Yamada, Yuto| Nakaya, Naoki| Fujimori, Maiko| So, Ryuhei| Kodama, Masafumi| Higuchi, Yuji| Kakeda, Kyoko| Uchitomi, Yosuke| Yamada, Norihito| Inagaki, Masatoshi|
Abstract It is necessary to assess functional impairment when treating schizophrenia. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) has been adopted as a measure of functional disability in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. This study was a secondary analysis from a cross-sectional study of health-related behaviors among patients with schizophrenia. We examined the validity and reliability of the Japanese version of the 12-item WHODAS 2.0 when self-administered by such patients. Participants were 350 outpatients with schizophrenia from a psychiatric hospital. The standard six-factor structure of the WHODAS 2.0 showed a good fit for these participants. The Cronbach’s alpha coefficient was 0.858, showing good internal consistency. The WHODAS 2.0 showed moderate correlations with the modified Global Assessment of Functioning and Kessler 6 scales (r=−0.434 and 0.555, respectively). The results of this study show that the Japanese version of the 12-item self-administered WHODAS 2.0 has good internal consistency and convergent validity among patients with schizophrenia. Further exploration of the usefulness of WHODAS 2.0 in clinical settings is needed.
Keywords disability schizophrenia validity reliability WHODAS 2.0
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-06
Volume volume75
Issue issue3
Publisher Okayama University Medical School
Start Page 315
End Page 322
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34176935
NAID 120007089823