result 752 件
| FullText URL | fulltext20230112-2.pdf |
|---|---|
| Author | Toda, Yuichiro| Ozasa, Koki| Matsuno, Takayuki| |
| Keywords | Growing neural gas 3D perception Navigation system |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10015-022-00826-y| This full-text file will be available in Nov. 2023.| |
| Published Date | 2022-11-09 |
| Publication Title | Artificial Life and Robotics |
| Volume | volume28 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 76 |
| End Page | 88 |
| ISSN | 1433-5298 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © International Society of Artifcial Life and Robotics (ISAROB) 2022 |
| File Version | author |
| DOI | 10.1007/s10015-022-00826-y |
| Web of Science KeyUT | 000880515200001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10015-022-00826-y |
| FullText URL | fulltext20221223-1.pdf |
|---|---|
| Author | Kawashima, Shusuke| Togashi, Yosuke| |
| Keywords | immune checkpoint inhibitors tumor microenvironment antitumor immunity primary resistance acquired resistance |
| Note | This is the peer reviewed version of the following article: [Kawashima, S, Togashi, Y. Resistance to immune checkpoint inhibitors and the tumor microenvironment. Exp Dermatol. 2022; 00: 1- 10. doi:10.1111/exd.14716], which has been published in final form at [https://doi.org/10.1111/exd.14716]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This full-text will be available in Nov. 2023.| |
| Published Date | 2022-12-08 |
| Publication Title | Experimental Dermatology |
| Volume | volume32 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 240 |
| End Page | 249 |
| ISSN | 0906-6705 |
| NCID | AA10958794 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| File Version | author |
| PubMed ID | 36437644 |
| DOI | 10.1111/exd.14716 |
| Web of Science KeyUT | 000894179800001 |
| Related Url | isVersionOf https://doi.org/10.1111/exd.14716 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kakiuchi, Yoshihiko| Kikuchi, Satoru| Kuroda, Shinji| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | Remnant gastric cancer Prognostic factor Tumor-infiltrating lymphocytes CD8(+) T cell Tumor immunity |
| Published Date | 2022-11-30 |
| Publication Title | World Journal Of Surgical Oncology |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 374 |
| ISSN | 1477-7819 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 36451224 |
| DOI | 10.1186/s12957-022-02853-2 |
| Web of Science KeyUT | 000892980100002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12957-022-02853-2 |
| FullText URL | fulltext20221130-3.pdf |
|---|---|
| Author | Sato, Ryosuke| Matsumoto, Kazuyuki| Kanzaki, Hiromitsu| Matsumi, Akihiro| Miyamoto, Kazuya| Morimoto, Kosaku| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Tsutsumi, Koichiro| Horiguchi, Shigeru| Kato, Hironari| |
| Keywords | Endoscopic ultrasound-guided fine needle aspiration Linitis plastica Autoimmune pancreatitis Paraneoplastic syndromes Case report |
| Note | Sato R, Matsumoto K, Kanzaki H, Matsumi A, Miyamoto K, Morimoto K, Terasawa H, Fujii Y, Yamazaki T, Uchida D, Tsutsumi K, Horiguchi S, Kato H. Gastric linitis plastica with autoimmune pancreatitis diagnosed by an endoscopic ultrasonography-guided fine-needle biopsy: A case report. World J Clin Cases 2022; 10(31): 11607-11616 [PMID: 36387831 DOI: 10.12998/wjcc.v10.i31.11607]| |
| Published Date | 2022-11-6 |
| Publication Title | World Journal of Clinical Cases |
| Volume | volume10 |
| Issue | issue31 |
| Publisher | Baishideng Publishing Group Inc. |
| Start Page | 11607 |
| End Page | 11616 |
| ISSN | 2307-8960 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 36387831 |
| DOI | 10.12998/wjcc.v10.i31.11607 |
| Web of Science KeyUT | 000885256200043 |
| FullText URL | fulltext20221122-4.pdf |
|---|---|
| Author | Yamaguchi, Kizashi| Shoji, Mitsuo| Isobe, Hiroshi| Kawakami, Takashi| Miyagawa, Koichi| Suga, Michihiro| Akita, Fusamichi| Shen, Jian-Ren| |
| Keywords | Water oxidation Oxygen evolution Photosystem II HR XRD SFX XFEL QM/MM calculation DLPNO CCSD(T-0) computations, Oxyl radical character |
| Note | (C) 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.ccr.2022.214742| This full-text file will be available in Aug. 2024.| |
| Published Date | 2022-11 |
| Publication Title | Coordination Chemistry Reviews |
| Volume | volume471 |
| Publisher | Elsevier BV |
| Start Page | 214742 |
| ISSN | 0010-8545 |
| NCID | AA00619249 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Elsevier B.V. |
| File Version | author |
| DOI | 10.1016/j.ccr.2022.214742 |
| Web of Science KeyUT | 000879286600003 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ccr.2022.214742 |
| FullText URL | fulltext20221122-2.pdf |
|---|---|
| Author | Tani, Yumeki| Ochiai, Kenta| Kaneta, Takashi| |
| Keywords | Optical force Extracellular vesicle exosome Gold nanoparticle Optical trapping |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s44211-022-00207-2| This full-text will be available in November 2023.| |
| Published Date | 2022-11-05 |
| Publication Title | Analytical Sciences |
| Volume | volume39 |
| Issue | issue5 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 643 |
| End Page | 651 |
| ISSN | 0910-6340 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022, The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry |
| File Version | author |
| PubMed ID | 36334243 |
| DOI | 10.1007/s44211-022-00207-2 |
| Web of Science KeyUT | 000879131000001 |
| Related Url | isVersionOf https://doi.org/10.1007/s44211-022-00207-2 |
| FullText URL | fulltext20221116-1.pdf |
|---|---|
| Author | Takahashi, Misa| Hagiya, Hideharu| Koyama, Toshihiro| Otsuka, Fumio| |
| Keywords | aging sexual health sexually transmitted infection spirochete syphilis |
| Note | This is the peer reviewed version of the following article: [Takahashi, M, Hagiya, H, Koyama, T, Otsuka, F. Trends in the incidence of syphilis in the middle-aged and older adults in Japan: A nationwide observational study, 2009–2019. Geriatr. Gerontol. Int. 2022; 22: 1019–1024. https://doi.org/10.1111/ggi.14500], which has been published in final form at [https://doi.org/10.1111/ggi.14500]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This full-text will be available in Nov. 2023.| |
| Published Date | 2022-11-01 |
| Publication Title | Geriatrics and Gerontology International |
| Volume | volume22 |
| Issue | issue12 |
| Publisher | Wiley |
| Start Page | 1019 |
| End Page | 1024 |
| ISSN | 1444-1586 |
| NCID | AA1155729X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Japan Geriatrics Society. |
| File Version | author |
| PubMed ID | 36320169 |
| DOI | 10.1111/ggi.14500 |
| Web of Science KeyUT | 000877369900001 |
| Related Url | isVersionOf https://doi.org/10.1111/ggi.14500 |
| JaLCDOI | 10.18926/AMO/64127 |
|---|---|
| FullText URL | 76_6_749.pdf |
| Author | Takami, Masanari| Yukawa, Yasutsugu| Noda, Yusuke| Yoshida, Munehito| Yamada, Hiroshi| |
| Abstract | We provide the first report of successful salvage surgery for a post-C1 laminectomy symptomatic recurrence of a retro-odontoid pseudotumor (ROP) that caused myelopathy. The 72-year-old Japanese woman presented with an ROP causing symptomatic cervical myelopathy. With ultrasonography support, we performed the enucleation of the ROP via a transdural approach and fusion surgery for the recurrence of the mass. At the final observation 2-year post-surgery, MRI demonstrated the mass’s regression and spinal cord decompression, and the patient’s symptoms had improved. Our strategy is an effective option for a symptomatic recurrence of ROP. |
| Keywords | recurrent retro-odontoid pseudotumor salvage surgery transdural resection C1 laminectomy ultra-sonography |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 749 |
| End Page | 754 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549779 |
| Web of Science KeyUT | 000905195100017 |
| JaLCDOI | 10.18926/AMO/64123 |
|---|---|
| FullText URL | 76_6_723.pdf |
| Author | Zhang, Quan| Yang, Lixia| Wan, Guozhen| Zhang, Xiaoqiang| Wang, Ying| Zhao, Guannan| |
| Abstract | The diagnostic value of microRNA-377 (miR-377) in patients with acute coronary syndrome (ACS) and explored miR-377’s potential mechanisms. We performed an qRT-PCR to assess serum miR-377 levels in ACS patients and coronary artery ligation rat models. The diagnostic value of miR-377 was evaluated by determining the ROC curve. An ELISA assay was conducted to detect the model rat endothelial damage markers von Willebrand factor (vWF) and heart-type fatty acid binding protein (H-FABP), and proinflammatory cytokines TNF-α, IL-6, and IL-1β. The serum miR-377 level was elevated in the ACS patients and significantly increased in the ACS rats. MiR-377 has a high diagnostic value in ACS patients, with a 0.844 ROC, 76.47% specificity, and 87.10% sensitivity. MiR-377 was positively correlated with the expressions of vWF, H-FABP, cTnI, TNF-α, IL-6, and IL-1β. In ACS rats, reducing the expression of miR-377 significantly inhibited the increases in vWF, H-FABP, TNF-α, IL-6, and IL-1β. An elevated miR-377 level can be used as a diagnostic marker in patients with ACS. A reduction of miR-377 may alleviate ACS by improving myocardial damage such as endothelial injury and the inflammatory response. |
| Keywords | microRNA-377 acute coronary syndrome diagnosis endothelial injury inflammatory |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 723 |
| End Page | 730 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549775 |
| Web of Science KeyUT | 000905195100013 |
| JaLCDOI | 10.18926/AMO/64121 |
|---|---|
| FullText URL | 76_6_705.pdf |
| Author | Higashikawa, Toshihiro| Ito, Tomohiko| Mizuno, Takurou| Ishigami, Keiichiro| Kuroki, Kengo| Maekawa, Naoto| Usuda, Daisuke| Izumida, Toshihide| Yamada, Shinya| Sangen, Ryusho| Hamada, Kazu| Kiyosawa, Jun| Saito, Atsushi| Iguchi, Masaharu| Kasamaki, Yuji| Nakahashi, Takeshi| Fukuda, Akihiro| Saito, Hitoshi| Kanda, Tsugiyasu| Okuro, Masashi| |
| Abstract | The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function. |
| Keywords | tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 705 |
| End Page | 713 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549773 |
| Web of Science KeyUT | 000905195100011 |
| FullText URL | K0006693_abstract_review.pdf K0006693_fulltext.pdf K0006693_other_Figure.pdf K0006693_summary.pdf |
|---|---|
| Author | MIFUNE, Tomoyo| |
| Published Date | 2022-09-22 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6693号 |
| Granted Date | 2022-09-22 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2022 Elsevier Inc. |
| FullText URL | K0006692_abstract_review.pdf K0006692_fulltext.pdf K0006692_other1.png K0006692_other2.png K0006692_other3.png K0006692_other4.png K0006692_other5.png K0006692_other6.png K0006692_summary.pdf |
|---|---|
| Author | TAKEUCHI, Keiko| |
| Published Date | 2022-09-22 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6692号 |
| Granted Date | 2022-09-22 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | ©2022 American Institute of Ultrasound in Medicine |
| FullText URL | K0006685_abstract_review.pdf K0006685_summary.pdf |
|---|---|
| Author | KUROOKA, Naoko| |
| Published Date | 2022-09-22 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6685号 |
| Granted Date | 2022-09-22 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/64043 |
|---|---|
| FullText URL | 76_5_605.pdf |
| Author | Teraishi, Fuminori| Jikuhara, Atsushi| Ogawa, Ryunosuke| Fujiwara, Toshiyoshi| |
| Abstract | An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation. |
| Keywords | BRAF V600E mutation cecal cancer, MSI-high |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 605 |
| End Page | 608 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352809 |
| Web of Science KeyUT | 000884907100015 |
| JaLCDOI | 10.18926/AMO/64042 |
|---|---|
| FullText URL | 76_5_597.pdf |
| Author | Watanabe, Shiho| Watanabe, Toshiyuki| Yamada, Kiyoshi| Namba, Yuzaburo| Kimata, Yoshihiro| |
| Abstract | Gender affirming surgery (GAS) has important impacts for people with gender incongruence (GI), both physically and socially. As the societal acceptance of gender diversity spreads, the number of individuals with GI who wish to be identified as the gender of their choice is increasing. Indeed, many elderly people who have lived a long time with GI now wish to undergo GAS, but face greater surgical risks due to greater burdens of underlying medical conditions. Generally, vaginoplasty is performed for transwomen; however, this surgery is time-consuming and involves heavy bleeding, and thus, should be avoided in elderly people. A less invasive technique is needed. In this article, we describe a new, less invasive genital feminizing surgical technique for transwomen with reports from two clinical cases. We present this novel technique as a safe, aesthetic, and cost-effective option for gender-affirming surgery for transwomen. |
| Keywords | gender-affirming surgery, vaginoplasty gender incongruence transwomen |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 597 |
| End Page | 603 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352808 |
| Web of Science KeyUT | 000884907100014 |
| JaLCDOI | 10.18926/AMO/64040 |
|---|---|
| FullText URL | 76_5_585.pdf |
| Author | Choshi, Haruki| Watanabe, Mototsugu| Furukawa, Shinichi| Ujike, Hiroyuki| Kataoka, Kazuhiko| |
| Abstract | Pulmonary metastatic resection is a standard therapy for renal cell carcinoma (RCC). Although patients with pulmonary metastases who do not undergo any treatment have poor prognoses, it has been reported that resection for pulmonary metastases yields good clinical outcomes. We investigated the prognoses of the 10 Japanese patients (eight males, two females) who underwent a surgical resection of pulmonary metastasectomy from RCC at our institution between April 1, 2012 and March 31, 2020 and analyzed the prognostic factors. We determined the prognoses and calculated the 5-year overall survival (OS) and disease-free survival (DFS) rates. To identify prognostic factors, we compared the median DFS duration for each factor. Elderly patients (median age, 75.5 years) were more predominant compared to previous studies, and all 10 patients underwent a complete resection. The 5-year DFS rate was 30.5% (95%CI: 0.045-0.63) and the 5-year OS rate was 80% (95%CI: 0.20-0.97). The following factors were associated with better prognosis: female, disease-free interval≥36 months, and metastases size<12 mm. These results indicate that complete resection for pulmonary metastases from RCC resulted in good clinical outcomes, particularly for patients with better prognostic factors. |
| Keywords | renal cell carcinoma pulmonary metastasis complete resection |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 585 |
| End Page | 591 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352806 |
| Web of Science KeyUT | 000884907100012 |
| JaLCDOI | 10.18926/AMO/64039 |
|---|---|
| FullText URL | 76_5_577.pdf |
| Author | Okutani, Yuki| Fujita, Hiroshi| Harada, Hideto| Kataoka, Masanao| Murotani, Yoshiki| Shimizu, Yu| |
| Abstract | The prevalence of preoperative deep vein thrombosis (DVT) has been reported to be relatively high in patients undergoing total hip arthroplasty. We investigated the prevalence of DVT, the association between hip function and preoperative DVT, and the effect of a history of surgery in patients who underwent primary total hip arthroplasty. We retrospectively analyzed the cases of the patients who underwent primary total hip arthroplasty between April 2013 and February 2020 at our institution. We evaluated the prevalence of preoperative DVT based on the results of the patients’ ultrasound screening. We performed univariate and multivariate analyses to investigate the association between the incidence of DVT and patient factors including age, sex, hip function, medical histories, and American Society of Anesthesiologists Physical Status classification. We analyzed 451 patients (494 hips). The prevalence of DVT was 14.2% (64 patients). The multivariate analysis demonstrated that increased age was an independent significant risk factor for DVT. The prevalence of preoperative DVT was relatively high among patients who underwent primary total hip arthroplasty. Preoperative DVT tended to be more prevalent in older patients. Hip function was not associated with the incidence of DVT. |
| Keywords | total hip arthroplasty deep vein thrombosis hip function ultrasound screening |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 577 |
| End Page | 584 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352805 |
| Web of Science KeyUT | 000884907100011 |
| JaLCDOI | 10.18926/AMO/64032 |
|---|---|
| FullText URL | 76_5_519.pdf |
| Author | Ishioka, Yoko| Yamashita, Hiroyuki| Hamaguchi, Kinya| Kuwahara, Yoshitaka| Nakamura, Kaoru| Nakatsuka, Mikiya| |
| Abstract | To examine the outcome of gestational blood pressure and birth weight in women with normal pre-pregnancy BMI (18.5-25 kg/m2) who are at the lower and upper limits of this range, i.e., slightly underweight or slightly overweight. Overall, 2,038 Japanese women with low -risk who had delivered during January 2014–December 2016 were classified according to their pre-pregnancy BMI: underweight (< 18.5 kg/m2), slightly underweight (18.5≤BMI<21 kg/m2), normal (21≤BMI<23 kg/m2), slightly overweight (23≤BMI<25 kg/m2) and overweight (≤ 25 kg/m2). Their blood pressure during each trimester and birth weight was evaluated. The slightly overweight group showed a significantly higher blood pressure than the underweight and slightly underweight groups. Birth weight was lower in the slightly underweight than in the slightly overweight group (p<0.01). The incidence rate of “heavy for dates” (HFD) infants was significantly higher in the slightly overweight and overweight groups than in the other groups (p<0.05 and p<0.01, respectively). Weight gain of < 7 kg significantly increased the rate of “light for dates” (LFD) infants, while a weight gain of ≥13 kg significantly increased the rate of HFD infants (p<0.05 and p<0.01, respectively). Blood pressure during pregnancy was ssociated with pre-pregnancy BMI. The birth weight of infants of low-risk pregnant women is affected by both pre-pregnancy BMI and gestational weight gain. |
| Keywords | birth weight blood pressure normal body weight pregnancy pre-pregnancy BMI |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 519 |
| End Page | 526 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352798 |
| Web of Science KeyUT | 000884907100004 |
| JaLCDOI | 10.18926/AMO/64025 |
|---|---|
| FullText URL | 76_5_503.pdf |
| Author | Ogawa, Hirohito| Honda, Tomoyuki| |
| Abstract | Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. |
| Keywords | EVE nrEVE bornavirus filovirus antiviral |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 503 |
| End Page | 510 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352796 |
| Web of Science KeyUT | 000884907100002 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| FullText URL | 76_5_489.pdf |
| Author | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| Keywords | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 489 |
| End Page | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
