result 705 件
| JaLCDOI | 10.18926/AMO/61438 |
|---|---|
| FullText URL | 75_1_79.pdf |
| Author | Yoshio, Kotaro| Nagasaka, Hisako| Hisazumi, Kento| Okawa, Hiro| Tajiri, Nobuhisa| Shiode, Tsuyoki| Akaki, Shiro| Kanazawa, Susumu| Mitoma, Tomohiro| Yano, Yuri| Kobayashi, Emiko| Horiguchi, Ikuyo| Takata, Masayo| Hongo, Atsushi| Yonezawa, Masaru| Nakanishi, Yoshie| |
| Abstract | The purposes of this retrospective study were to analyze local control of squamous cell carcinoma of the cervix treated with computed tomography (CT)-based image-guided brachytherapy (IGBT), as well as the factors affecting local control. A total of 39 patients were analyzed. The prescribed dose to the pelvis was 45-50 Gy with or without central shielding (CS). IGBT was delivered in 1-5 fractions. The total dose for high-risk clinical target volume (HR-CTV) was calculated as the biologically equivalent dose in 2-Gy fractions. The median follow-up period was 29.3 months. The 2-year overall survival and local control rates were 97% and 91%, respectively. In univariate analysis, the dose covering 90% of the HR-CTV (D90) and tumor size were found to be significant factors for local control. The cutoff values of tumor size and D90 for local control were 4.3 cm (area under the curve [AUC] 0.75) and 67.7 Gy (AUC 0.84) in the CS group and 5.3 cm (AUC 0.75) and 73.7 Gy (AUC 0.78) in the group without CS, respectively. However, though the local control of CT-based IGBT was favorable, the results suggested that the dose required for tumor control may differ depending on the presence of CS. |
| Keywords | cervical cancer squamous cell cancer brachytherapy central shielding |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 79 |
| End Page | 85 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649617 |
| JaLCDOI | 10.18926/AMO/61430 |
|---|---|
| FullText URL | 75_1_25.pdf |
| Author | Tetsunaga, Tomonori| Tetsunaga, Tomoko| Yamada, Kazuki| Sanki, Tomoaki| Kawamura, Yoshi| Ozaki, Toshifumi| |
| Abstract | In bipolar hemiarthroplasty (BHA), it is important to preserve soft tissue to reduce the risk of postoperative dislocation. A variety of surgical approaches for BHA are available, but extra care is needed with muscle- and tendon-preserving approaches in geriatric patients. We investigated the usefulness of BHA using a conjoined tendon-preserving posterior (CPP) approach, in which only the external obturator muscle is dissected, in geri-atric patients. We retrospectively analyzed the cases of 40 femoral neck fracture patients (10 men, 30 women) aged ≥ 80 years who underwent BHA using the CPP approach. The patients’ average age was 85.8 years (80-94 years). We examined the operation time, bleeding, preservation of short external rotator muscles, complica-tions, and stem alignment and subsidence from postoperative radiographs. Although gemellus inferior muscle injury was detected in 4 patients (10%), the hip joint stability was very excellent in all cases. There was no intraoperative fracture or postoperative dislocation. On postoperative radiographs, all femoral stems were in a neutral position. There was no stem subsidence in all 40 patients. BHA using the CPP approach appeared to be useful even in geriatric patients. |
| Keywords | bipolar hip arthroplasty geriatric patient conjoined tendon-preserving posterior approach |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 25 |
| End Page | 30 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649610 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ikeda, A.| Yamamoto, T.| Mineshiba, J.| Takashiba, S.| |
| Published Date | 2020-11-17 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 19959 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 33203957 |
| DOI | 10.1038/s41598-020-77004-2 |
| Web of Science KeyUT | 000604508600003 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-77004-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tran, Manh Tien| Okusha, Yuka| Feng, Yunxia| Morimatsu, Masatoshi| Wei, Penggong| Sogawa, Chiharu| Eguchi, Takanori| Kadowaki, Tomoko| Sakai, Eiko| Okamura, Hirohiko| Naruse, Keiji| Tsukuba, Takayuki| Okamoto, Kuniaki| |
| Keywords | Rab11b c-Fms RANK NFATc-1 osteoclasts vesicular transport |
| Published Date | 2020-12-08 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume21 |
| Issue | issue24 |
| Publisher | MDPI |
| Start Page | 9352 |
| ISSN | 1422-0067 |
| NCID | AA12038549 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 33302495 |
| DOI | 10.3390/ijms21249352 |
| Web of Science KeyUT | 000603505100001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms21249352 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ji, Yuhao| Ryuji, Yuki| Matsumura, Kentarou| Miyatake, Takahisa| |
| Keywords | mating latency mounting behavior number of mating red flour beetle reproductive success sperm competition |
| Note | This is the peer reviewed version of the following article: Ji Yuhao et. al. Effects of caffeine on mating behavior and sperm precedence in Tribolium castaneum. Ethology 127(1), 45-49 (2021), which has been published in final form at https://doi.org/10.1111/eth.13094. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| |
| Published Date | 2021-01 |
| Publication Title | Ethology |
| Volume | volume127 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | 45 |
| End Page | 49 |
| ISSN | 0179-1613 |
| NCID | AA10516300 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1111/eth.13094 |
| Web of Science KeyUT | 000598044100004 |
| Related Url | isVersionOf https://doi.org/10.1111/eth.13094 |
| JaLCDOI | 10.18926/AMO/61213 |
|---|---|
| FullText URL | 74_6_531.pdf |
| Author | Hashimoto, Kazuhiko| Nishimura, Shunji| Chikugo, Takaaki| Kakinoki, Ryosuke| Akagi, Masao| |
| Abstract | Soft tissue myoepitheliomas are often misdiagnosed due to their rarity. Herein, we describe a case of soft tissue myoepithelioma of the shoulder. A 72-year-old woman had a suspected sarcoma on her shoulder and under-went open biopsy. She was referred to our hospital, where the tumor was widely resected and the diagnosis of myoepithelioma was histologically confirmed. No recurrence has been observed in the 3 years since the sur-gery. Careful and prompt planning is necessary for the effective treatment of myoepithelioma. |
| Keywords | soft tissue myoepithelioma unplanned resection shoulder |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 531 |
| End Page | 535 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361874 |
| Web of Science KeyUT | 000601203600010 |
| NAID | 120006948952 |
| JaLCDOI | 10.18926/AMO/61211 |
|---|---|
| FullText URL | 74_6_521.pdf |
| Author | Itazaki, Yujiro| Tsujimoto, Hironori| Sugasawa, Hidekazu| Yaguchi, Yoshihisa| Nomura, Shinsuke| Ito, Nozomi| Harada, Manabu| Sugihara, Takao| Tsuchiya, Satoshi| Ishibashi, Yusuke| Kouzu, Keita| Kishi, Yoji| Ueno, Hideki | |
| Abstract | We report a successful dissection of metastatic posterior thoracic para-aortic lymph node (No. 112aoP) via bilateral thoracoscopic surgery. With the anesthetized patient (a 73-year-old Japanese woman) in the prone position, two working ports were inserted for the left-side approach, and artificial pneumothorax was created. Thoracoscopic examination revealed a swollen LN posterior to the descending aorta. Fat and metastatic LNs posterior to the aorta were dissected from the aortic arch level to the diaphragm while preserving intercostal arteries. For the right-side approach, two working ports were inserted and a routine thoracoscopic esophagec-tomy was performed. Gastric conduit reconstruction was achieved laparoscopically. Operation time for the left thoracic procedure: 54 min; estimated blood loss: almost none. No recurrence was detected 24 months post-operatively. There are several surgical options for approaching No. 112aoP, including transhiatal, left thora-cotomy, and thoracoscopy. Although a wide dissection of the posterior thoracic para-aortic area has not been reported, it may be feasible and safe if the artery of Adamkiewicz and intercostal arteries are preserved. A min-imally invasive bilateral thoracoscopic approach for a thoracoscopic esophagectomy is safe and useful for esophageal cancer patients with solitary No. 112aoP metastasis. |
| Keywords | bilateral approach posterior thoracic para-aortic lymph node thoracoscopic esophagectomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 521 |
| End Page | 524 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361872 |
| Web of Science KeyUT | 000601203600008 |
| NAID | 120006948950 |
| JaLCDOI | 10.18926/AMO/61205 |
|---|---|
| FullText URL | 74_6_467.pdf |
| Author | Yokota, Yuya| Nishimura, Yoshito| Ando, Akemi| Hanayama, Yoshihisa| Hasegawa, Kou| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Ueda, Keigo| Otsuka, Fumio| |
| Abstract | Alkaline phosphatase (ALP) is an enzyme that is expressed in a variety of tissues. Among the isoforms of ALP, bone-specific alkaline phosphatase (BAP) is used as a marker for evaluating bone metabolism. We investigated the clinical usefulness of the ratio of serum BAP to total ALP for the diagnosis of various disorders in general practice. We retrospectively analyzed the cases of 107 Japanese patients whose serum BAP levels were exam-ined, focusing on clinical characteristics. We observed that the BAP/ALP ratios of the patients with fever and those with inflammatory diseases were significantly lower than the ratios of other patient groups. The BAP/ALP ratios of the patients with osteoporosis and those with metabolic bone diseases were higher than those of the patients with other conditions. The BAP/ALP ratio was found to be negatively correlated with age, a cor-relation that has not been found in other ethnicities. The serum BAP/ALP ratio was inversely correlated with serum CRP levels but was positively correlated with serum albumin levels and hemoglobin concentrations. Collectively, our results suggest that the BAP/ALP ratio could be a useful predictor for important geriatric con-ditions seen in general practice. |
| Keywords | alkaline phosphatase BAP CRP inflammation osteoporosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 467 |
| End Page | 474 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361866 |
| Web of Science KeyUT | 000601203600002 |
| NAID | 120006948955 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Michiue, Hiroyuki| Kitamatsu, Mizuki| Fukunaga, Asami| Tsuboi, Nobushige| Fujimura, Atsushi| Matsushita, Hiroaki| Igawa, Kazuyo| Kasai, Tomonari| Kondo, Natsuko| Matsui, Hideki| Furuya, Shuichi| |
| Keywords | Malignant brain tumor Boron neutron capture therapy (BNCT) Peptide nanotube Boron drug Drug delivery system (DDS) A6K peptide |
| Published Date | 2020-11-11 |
| Publication Title | Journal of Controlled Release |
| Volume | volume330 |
| Publisher | Elsevier |
| Start Page | 788 |
| End Page | 196 |
| ISSN | 0168-3659 |
| NCID | AA10458678 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Author(s). |
| File Version | publisher |
| PubMed ID | 33188824 |
| DOI | 10.1016/j.jconrel.2020.11.001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jconrel.2020.11.001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyaji, Mary| Furuta, Ryohei| Hosoya, Osamu| Sano, Kuniaki| Hara, Norikazu| Kuwano, Ryozo| Kang, Jiyoung| Tateno, Masaru| Tsutsui, Kimiko M.| Tsutsui, Ken| |
| Keywords | Biochemistry Molecular biology |
| Published Date | 2020-10-29 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 18550 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 33122676 |
| DOI | 10.1038/s41598-020-75004-w |
| Web of Science KeyUT | 000587689500013 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-75004-w |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Habuta, Munenori| Yasue, Akihiro| Suzuki, Ken-Ichi T.| Fujita, Hirofumi| Sato, Keita| Kono, Hitomi| Takayama, Ayuko| Bando, Tetsuya| Miyaishi, Satoru| Oyadomari, Seiichi| Tanaka, Eiji| Ohuchi, Hideyo| |
| Published Date | 2020-10-15 |
| Publication Title | PLoS ONE |
| Volume | volume15 |
| Issue | issue10 |
| Publisher | Public Library of Science |
| Start Page | e0240333 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Habuta et al. |
| File Version | publisher |
| PubMed ID | 33057360 |
| DOI | 10.1371/journal.pone.0240333 |
| Web of Science KeyUT | 000581814700082 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0240333 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Aung, Kyaw Thu| Akiyama, Kentaro| Kunitomo, Masayoshi| Mun, Aung Ye| Tosa, Ikue| Nguyen, Ha Thi Thu| Zhang, Jiewen| Kohno, Teisaku| Ono, Mitsuaki| Hara, Emilio Satoshi| Kuboki, Takuo| |
| Keywords | mesenchymal stem cell aging tissue destruction periodontitis immunomodulation bone resorption |
| Published Date | 2020-10-30 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume21 |
| Issue | issue21 |
| Publisher | MDPI |
| Start Page | 8103 |
| ISSN | 1422-0067 |
| NCID | AA12038549 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 33143068 |
| DOI | 10.3390/ijms21218103 |
| Web of Science KeyUT | 000589055400001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms21218103 |
| FullText URL | fulltext.pdf figures.pdf SuppleFigures.pdf |
|---|---|
| Author | Mochizuki, Yusuke| Tazawa, Hiroshi| Demiya, Koji| Kure, Miho| Kondo, Hiroya| Komatsubara, Tadashi| Sugiu, Kazuhisa| Hasei, Joe| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | Oncolytic adenovirus hTERT Immunogenic cell death ATP CD8 |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Cancer Immunology, Immunotherapy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00262-020-02774-7.| |
| Published Date | 2020-11-05 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume70 |
| Publisher | Springer |
| Start Page | 1405 |
| End Page | 1417 |
| ISSN | 0340-7004 |
| NCID | AA00598499 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33151368 |
| DOI | 10.1007/s00262-020-02774-7 |
| Web of Science KeyUT | 000586350500002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00262-020-02774-7 |
| Author | Yamauchi, Toshihiro| Ikegami, Yuta| |
|---|---|
| Published Date | 2016-09-21 |
| Publication Title | Network and System Security(NSS) |
| Volume | volume2016 |
| Content Type | Conference Paper |
| Author | Sakamoto, Syunya| |
|---|---|
| Published Date | 2013-05-03 |
| Publication Title | Multimedia and Ubiquitous Engineering |
| Content Type | Book |
| JaLCDOI | 10.18926/AMO/60806 |
|---|---|
| FullText URL | 74_5_443.pdf |
| Author | Sekito, Takanori| Araki, Motoo| Hiraki, Takao| Uka, Mayu| Komaki, Toshiyuki| Matsui, Yusuke| Iguchi, Toshihiro| Katayama, Satoshi| Yoshinaga, Kasumi| Watari, Shogo| Maruyama, Yuki| Mitsui, Yosuke| Kubota, Risa| Sadahira, Takuya| Nishimura, Shingo| Wada, Koichiro| Takamoto, Atsushi| Edamura, Kohei| Sako, Tomoko| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Kanazawa, Susumu| Nasu, Yasutomo| |
| Abstract | We report a 47-year-old Japanese female with 10 previous treatments for multiple bilateral renal cell carcinoma (RCC) associated with von Hippel-Lindau disease. The 14-mm right lower pole renal tumor was in contact with the right ureter. Laparoscopic cryoablation was performed to protect the ureter wrapped with gauze. Computed tomography (CT) monitoring was used to confirm the precise ≥ 6 mm ice-ball margin. There was no local progression at 6-months post-surgery. The serum creatinine has been stable. This is apparently the first report of combined laparoscopic and CT monitoring of an ice-ball formation and its margin during cryoablation for RCC. |
| Keywords | laparoscopic cryoablation multiple renal masses nephron-sparing surgery renal cell carcinoma von Hippel-Lindau disease |
| Amo Type | Case Report |
| Note | Fig. 1B is replaced on Dec. 23, 2020.| |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 443 |
| End Page | 448 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106702 |
| Web of Science KeyUT | 000581970100011 |
| NAID | 120006892932 |
| JaLCDOI | 10.18926/AMO/60800 |
|---|---|
| FullText URL | 74_5_407.pdf |
| Author | Togo, Masaaki| Akazawa, Yuko| Akashi, Taro| Yamashita, Rika| Yoshitomi, Izumi| Ohba, Kazuo| Hashimoto, Satsuki| Iwashita, Hiroko| Kurogi, Tadafumi| Osada, Yukiko| Wada, Noriko| Imamura, Yoshifumi| Hashiguchi, Keiichi| Yamaguchi, Naoyuki| Kondo, Hisayoshi| Nakao, Kazuhiko| |
| Abstract | Endoscopic submucosal dissection (ESD) has become the first-line treatment for early gastric neoplasms; however, a subset of patients treated by this method develop aspiration pneumonia. We conducted a comprehensive prospective analysis of the factors contributing to post-ESD aspiration pneumonia in early gastric neoplasms in this study, with special focus on whether pre-treatment oral care can prevent aspiration pneumonia. Sixty-one patients who underwent ESD for gastric neoplasms were randomly assigned to the oral care or control groups. ESD was performed under deep sedation. Of 60 patients whose data were available for analysis, 5 (8.3%) experienced pneumonia confirmed either by chest radiography or computed tomography. Although no difference in the rate of pneumonia was found between the control and oral care groups, the post-oral care bacteria count was significantly higher in the saliva of patients who developed pneumonia compared to those without pneumonia. In addition, the presence of vascular brain diseases and the dose of meperidine were also significantly associated with the occurrence of pneumonia. These results suggest that the number of oral bacteria as well as pre-existing vascular brain diseases and high-dose narcotics can affect the incidence of post-ESD pneumonia. |
| Keywords | endoscopy oral bacteria respiratory disease pneumonia sedation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 407 |
| End Page | 413 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106696 |
| Web of Science KeyUT | 000581970100005 |
| NAID | 120006892926 |
| JaLCDOI | 10.18926/AMO/60796 |
|---|---|
| FullText URL | 74_5_371.pdf |
| Author | Makimoto, Go| Ohashi, Kadoaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Abstract | The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms. |
| Keywords | lung cancer anaplastic lymphoma kinase tyrosine kinase inhibitors resistance mechanism |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 371 |
| End Page | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106692 |
| Web of Science KeyUT | 000581970100001 |
| NAID | 120006892922 |
| Author | Moriyama, Hideaki| Yamauchi, Toshihiro| Sato, Masaya| Taniguchi, Hideo| |
|---|---|
| Published Date | 2020-08-20 |
| Publication Title | Advances in Networked-Based Information Systems |
| Content Type | Conference Paper |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Terada, Keiko| Sakurai, Mikako| Liu, Shihu| Yamashita, Koichiro| Uchida, Tetsuya| |
| Keywords | Photoelectric dye Polyethylene thin film Spike Degenerative retina Retinal dystrophic rd1 mouse |
| Published Date | 2020-08-10 |
| Publication Title | Clinics in Surgery |
| Volume | volume5 |
| Publisher | Remedy |
| Start Page | 2903 |
| ISSN | 2474-1647 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Matsuo T. |
| File Version | publisher |
| Official Url | http://www.clinicsinsurgery.com/| |
