result 620 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Murakami, Toshi| Tanaka, Takehiro| Oka, Shohei| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Published Date | 2020-06-04 |
| Publication Title | Case Reports in Gastrointestinal Medicine |
| Volume | volume2020 |
| Publisher | Hindawi |
| Start Page | 6381670 |
| ISSN | 2090-6528 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 32566328 |
| DOI | 10.1155/2020/6381670 |
| Web of Science KeyUT | 000542326600001 |
| Related Url | isVersionOf https://doi.org/10.1155/2020/6381670 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Miyahara, Koji| Sakaguchi, Chihiro| Takenaka, Ryuta| Kobayashi, Sayo| Mouri, Hirokazu| Tanaka, Shigetomi| Toyokawa, Tatsuya| Tanaka, Shouichi| Nishimura, Mamoru| Yamauchi, Kenji| Tanaka, Takehiro| Okada, Hiroyuki| |
| Keywords | 18F-fluorodeoxyglucose-positron emission tomography mesenchymal tumor gastric neoplasms gastrointestinal stromal tumor schwannoma |
| Published Date | 2020-05-01 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume9 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 1301 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32370028 |
| DOI | 10.3390/jcm9051301 |
| Web of Science KeyUT | 000540223800058 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm9051301 |
| JaLCDOI | 10.18926/AMO/59958 |
|---|---|
| FullText URL | 74_3_245.pdf |
| Author | Yamamoto, Shumpei| Takayama, Hiroshi| Shimodate, Yuichi| Takezawa, Rio| Nishimura, Naoyuki| Doi, Akira| Mouri, Hirokazu| Matsueda, Kazuhiro| Mizuno, Motowo| Okada, Hiroyuki| |
| Abstract | Antithrombotic therapy is a major risk factor for delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasia. A potassium-competitive acid blocker, vonoprazan, is expected to prevent delayed bleeding better than conventional proton pomp inhibitors (PPIs), but the evidence is controversial. We sought to clarify the efficacy of vonoprazan for prevention of delayed bleeding after gastric ESD in patients under antithrombotic therapy. We prospectively registered 50 patients who underwent gastric ESD while receiving antithrombotic therapy and vonoprazan in our institution between October 2017 and September 2018. The incidence of delayed bleeding was compared with that in a historical control group of 116 patients treated with conventional PPI. We also evaluated risk factors associated with delayed bleeding. Delayed bleeding was observed in 8 of 50 patients (16.0%), which was not dissimilar from the incidence in the historical control group (12.1%) (p=0.49). In the univariate analysis, age (> 70 years) (p=0.034), multiple antithrombotic drug use (p<0.01), procedure time (> 200 min) (p=0.038) and tumor size (> 40 mm) (p<0.01) were associated with delayed bleeding after gastric ESD, but vonoprazan was not (p=0.49). Vonoprazan may not be more effective than conventional PPIs in preventing delayed bleeding after gastric ESD in patients receiving antithrombotic therapy. |
| Keywords | vonoprazan endoscopic submucosal dissection antithrombotic drug gastric cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-06 |
| Volume | volume74 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 245 |
| End Page | 250 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32577023 |
| Web of Science KeyUT | 000543363400008 |
| NAID | 120006862799 |
| reference | Oda I, Saito D, Tada M, Iishi H, Tanabe S, Oyama T, Doi T, Otani Y, Fujisaki J, Ajioka Y, Hamada T, Inoue H, Gotoda T and Yoshida S: A multicenter retrospective study of endoscopic resection for early gastric cancer. Gastric Cancer (2006) 9: 262-270.| Lian J, Chen S, Zhang Y and Qiu F: A meta-analysis of endoscopic submucosal dissection and EMR for early gastric cancer. Gastrointest Endosc (2012) 76: 763-770.| Park YM, Cho E, Kang HY and Kim JM: The effectiveness and safety of endoscopic submucosal dissection compared with endoscopic mucosal resection for early gastric cancer: a systematic review and metaanalysis. Surg Endosc (2011) 25: 2666-2677.| Goto O, Fujishiro M, Oda I, Kakushima N, Yamamoto Y, Tsuji Y, Ohata K, Fujiwara T, Fujiwara J, Ishii N, Yokoi C, Miyamoto S, Itoh T, Morishita S, Gotoda T and Koike K: A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding. Dig Dis Sci (2012) 57: 435-439.| Tsuji Y: Risk factors for bleeding after endoscopic submucosal dissection for gastric lesions. World Journal of Gastroenterology (2010) 16: 2913.| Furuhata T, Kaise M, Hoteya S, Iizuka T, Yamada A, Nomura K, Kuribayashi Y, Kikuchi D, Matsui A, Ogawa O, Yamashta S and Mitani T: Postoperative bleeding after gastric endoscopic submucosal dissection in patients receiving antithrombotic therapy. Gastric Cancer (2017) 20: 207-214.| Okada K, Yamamoto Y, Kasuga A, Omae M, Kubota M, Hirasawa T, Ishiyama A, Chino A, Tsuchida T, Fujisaki J, Nakajima A, Hoshino E and Igarashi M: Risk factors for delayed bleeding after endoscopic submucosal dissection for gastric neoplasm. Surg Endosc (2011) 25: 98-107.| Dong J, Wei K, Deng J, Zhou X, Huang X, Deng M and Lu M: Effects of antithrombotic therapy on bleeding after endoscopic submucosal dissection. Gastrointest Endosc (2017) 86: 807-816.| Kono Y, Obayashi Y, Baba Y, Sakae H, Gotoda T, Miura K, Kanzaki H, Iwamuro M, Kawano S, Kawahara Y, Tanaka T and Okada H: Postoperative bleeding risk after gastric endoscopic submucosal dissection during antithrombotic drug therapy. J Gastroenterol Hepatol (2018) 33: 453-460.| Tounou S, Morita Y and Hosono T: Continuous aspirin use does not increase post-endoscopic dissection bleeding risk for gastric neoplasms in patients on antiplatelet therapy. Endosc Int Open (2015) 3: E31-38.| Gotoda T, Hori K, Iwamuro M, Kono Y, Miura K, Kanzaki H, Kawano S, Kawahara Y and Okada H: Evaluation of the bleeding risk with various antithrombotic therapies after gastric endoscopic submucosal dissection. Endosc Int Open (2017) 5: E653-E662.| Uedo N, Takeuchi Y, Yamada T, Ishihara R, Ogiyama H, Yamamoto S, Kato M, Tatsumi K, Masuda E, Tamai C, Yamamoto S, Higashino K, Iishi H and Tatsuta M: Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial. Am J Gastroenterol (2007) 102: 1610-1616.| Hamada K, Uedo N, Tonai Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Ishihara R, Okada H, Iishi H, Fukui K and Shimokawa T: Efficacy of vonoprazan in prevention of bleeding from endoscopic submucosal dissection-induced gastric ulcers: a prospective randomized phase II study. J Gastroenterol (2018).| Kagawa T, Iwamuro M, Ishikawa S, Ishida M, Kuraoka S, Sasaki K, Sakakihara I, Izumikawa K, Yamamoto K, Takahashi S, Tanaka S, Matsuura M, Hasui T, Wato M and Inaba T: Vonoprazan prevents bleeding from endoscopic submucosal dissection-induced gastric ulcers. Aliment Pharmacol Ther (2016) 44: 583-591.| Kato M, Uedo N, Hokimoto S, Ieko M, Higuchi K, Murakami K and Fujimoto K: Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment: 2017 Appendix on Anticoagulants Including Direct Oral Anticoagulants. Dig Endosc (2018) 30: 433-440.| Fujimoto K, Fujishiro M, Kato M, Higuchi K, Iwakiri R, Sakamoto C, Uchiyama S, Kashiwagi A, Ogawa H, Murakami K, Mine T, Yoshino J, Kinoshita Y, Ichinose M, Matsui T and Japan Gastroenterological Endoscopy S: Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. Dig Endosc (2014) 26: 1-14.| Kawai T, Oda K, Funao N, Nishimura A, Matsumoto Y, Mizokami Y, Ashida K and Sugano K: Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study. Gut (2018) 67: 1033-1041.| |
| JaLCDOI | 10.18926/AMO/59957 |
|---|---|
| FullText URL | 74_3_237.pdf |
| Author | Oyama, Atsushi| Uchida, Daisuke| Shiraha, Hidenori| Sawahara, Hiroaki| Kato, Ryo| Iwamuro, Masaya| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Abstract | The physiological role of the reduced expression of immortalized cells (REIC)/Dickkopf-3 (Dkk-3) protein in patients with hepatocellular carcinoma (HCC) remains unclear. In this study, we evaluated the effect of the REIC/Dkk-3 protein on HCC cell proliferation and assessed the relationship between the serum REIC/Dkk-3 protein level and the prognosis in patients with HCC. We evaluated the REIC/Dkk-3 protein-induced anticancer effects on Huh7 and Hep3B cells (HCC cell lines) in the presence of peripheral blood mononuclear cells (PBMCs), and found that combination treatment with REIC/Dkk-3 protein and PBMCs reduced the proliferation of HCC cells (Hep3B: 82.0%±16.3%; Huh7: 72.6%±9.1%). We also studied 194 HCC patients who underwent primary liver resection or primary radiofrequency ablation from 2008 to 2017. Serum REIC/Dkk-3 protein levels were measured by an enzyme-linked immunosorbent assay and compared to the prognostic data. The 3-year disease-free survival of the REIC/Dkk-3 high group was significantly higher than that in the REIC/Dkk-3 low group. In conclusion, this is the first study investigating the relationship between HCC patient survival and serum REIC/Dkk-3 protein levels in a large population. Based on the results, the serum REIC/Dkk-3 protein level should be considered a new prognostic marker for patients with HCC. |
| Keywords | enzyme-linked immunosorbent assay liver resection primary radiofrequency ablation Huh7 Hep3B |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-06 |
| Volume | volume74 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 237 |
| End Page | 243 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32577022 |
| Web of Science KeyUT | 000543363400007 |
| NAID | 120006862798 |
| FullText URL | Biomaterials_251_fulltext.pdf Biomaterials_251_supplementarydata.pdf |
|---|---|
| Author | Tanaka, Hiroyoshi Y.| Kurihara, Tsuyoshi| Nakazawa, Takuya| Matsusaki, Michiya| Masamune, Atsushi| Kano, Mitsunobu R.| |
| Keywords | 3D culture Cancer-associated fibroblast Pancreatic stellate cell Tumor stroma Pancreatic cancer Myofibroblast |
| Note | ©2021 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.biomaterials.2020.120077] . | |
| Published Date | 2020-04-30 |
| Publication Title | Biomaterials |
| Volume | volume251 |
| Publisher | Elsevier |
| Start Page | 120077 |
| ISSN | 0142-9612 |
| NCID | AA00110092 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32388166 |
| DOI | 10.1016/j.biomaterials.2020.120077 |
| Web of Science KeyUT | 000534057500006 |
| Related Url | isVersionOf https://doi.org/10.1016/j.biomaterials.2020.120077 |
| FullText URL | Biomaterials_192_fulltext.pdf Biomaterials_192_supplementarydata.pdf |
|---|---|
| Author | Tanaka, Hiroyoshi Y.| Kitahara, Kentaro| Sasaki, Naoki| Nakao, Natsumi| Sato, Kae| Narita, Hirokazu| Shimoda, Hiroshi| Matsusaki, Michiya| Nishihara, Hiroshi| Masamune, Atsushi| Kano, Mitsunobu R.| |
| Keywords | Fibrosis Extracellular matrix remodeling 3D culture Pancreatic stellate cell SPARC |
| Published Date | 2018-11-17 |
| Publication Title | Biomaterials |
| Volume | volume192 |
| Publisher | Elsevier |
| Start Page | 355 |
| End Page | 367 |
| ISSN | 0142-9612 |
| NCID | AA00110092 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30476717 |
| DOI | 10.1016/j.biomaterials.2018.11.023 |
| Web of Science KeyUT | 000456902000029 |
| Related Url | isVersionOf https://doi.org/10.1016/j.biomaterials.2018.11.023 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tazawa, Hiroshi| Hasei, Joe| Yano, Shuya| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | oncolytic adenovirus hTERT autophagy GFP p53 |
| Published Date | 2020-02-18 |
| Publication Title | Cancers |
| Volume | volume12 |
| Issue | issue2 |
| Publisher | MDPI |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32085583 |
| DOI | 10.3390/cancers12020478 |
| Web of Science KeyUT | 000522477300224 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers12020478 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Takahashi, Takahide| Ota, Yoko| Tanaka, Takehiro| Asada, Noboru| Yano, Shuya| Uka, Mayu| Nakamura, Rei| Baba, Yuki| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Published Date | 2020-04-09 |
| Publication Title | Case Reports in Gastrointestinal Medicine |
| Volume | volume2020 |
| Publisher | Hindawi |
| Start Page | 7947540 |
| ISSN | 2090-6528 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 32328319 |
| DOI | 10.1155/2020/7947540 |
| Web of Science KeyUT | 000528921300002 |
| Related Url | isVersionOf https://doi.org/10.1155/2020/7947540 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Naohisa| Matsusaki, Takashi| Hiroi, Kazumasa| Kaku, Ryuji| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Morimatsu, Hiroshi| |
| Note | 11th Congress of the Andalusian-Society-of-Organ-and-Tissue-Transplantation (SATOT)| |
| Published Date | 2020-03-31 |
| Publication Title | Transplantation Proceedings |
| Volume | volume52 |
| Issue | issue2 |
| Publisher | Elsevier |
| Start Page | 630 |
| End Page | 633 |
| ISSN | 00411345 |
| NCID | AA00868957 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. Published by Elsevier Inc. |
| File Version | publisher |
| PubMed ID | 32029317 |
| DOI | 10.1016/j.transproceed.2019.11.032 |
| Web of Science KeyUT | 000518473000059 |
| Related Url | isVersionOf https://doi.org/10.1016/j.transproceed.2019.11.032 |
| FullText URL | text_correction.pdf table3_correction.pdf |
|---|---|
| Author | Tomoda, Takeshi | Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Note | Correction to: Surgical Endoscopy https://doi.org/10.1007/s00464-020-07385-y| |
| Published Date | 2020-02-06 |
| Publication Title | Surgical Endoscopy |
| Volume | volume35 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 239 |
| End Page | 240 |
| ISSN | 09302794 |
| NCID | AA10750363 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32030547 |
| DOI | 10.1007/s00464-020-07399-6 |
| Web of Science KeyUT | 000515963500002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00464-020-07399-6 |
| FullText URL | fulltext.pdf table.pdf |
|---|---|
| Author | Tomoda, Takeshi| Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| chida, Daisuke| atsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Keywords | Malignant biliary obstruction Double-balloon enteroscope Endoscopic retrograde cholangiopancreatography Surgically altered anatomy |
| Note | This fulltext is aailable in Jan. 2021.| |
| Published Date | 2020-01-16 |
| Publication Title | Surgical Endoscopy |
| ISSN | 09302794 |
| NCID | AA10750363 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31950273 |
| DOI | 10.1007/s00464-020-07385-y |
| Web of Science KeyUT | 000507705600001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00464-020-07385-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsubara, Takehiro| Soh, Junichi| Morita, Mizuki| Uwabo, Takahiro| Tomida, Shuta| Fujiwara, Toshiyoshi| Kanazawa, Susumu| Toyooka, Shinichi| Hirasawa, Akira| |
| Published Date | 2020-02-27 |
| Publication Title | BioMed Research International |
| Volume | volume2020 |
| Publisher | Hindawi |
| Start Page | 9349132 |
| ISSN | 2314-6133 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Takehiro Matsubara et al. |
| File Version | publisher |
| PubMed ID | 32185225 |
| DOI | 10.1155/2020/9349132 |
| Web of Science KeyUT | 000522222100002 |
| Related Url | isVersionOf https://doi.org/10.1155/2020/9349132 |
| Title Alternative | Efficacy of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) or PPI plus a prokinetic in H. pylori-positive patients with dyspepsia |
|---|---|
| FullText URL | 131_139.pdf |
| Author | 三浦 公| Iwamuro, Masaya| Toyokawa, Tatsuya| Takenaka, Ryuta| Inoue, Masafumi| Ito, Mamoru| Okada, Hiroyuki| |
| Abstract | To investigate whether treatment comprised of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) alone and a dual treatment with a PPI plus a prokinetic agent helps relieve symptoms, we treated 26 patients with H. pylori infection and dyspepsia with the sequential treatment and assessed their symptoms. Scores for gastroesophageal reflux disease (GERD) and dyspepsia in a modified F-scale were significantly improved after the eradication of H. pylori, and symptoms were completely relieved in 13 patients. The remaining 13 patients received 4-week treatment with the PPI rabeprazole, and their GERD scores significantly improved after the treatment. The symptoms of five patients completely disappeared ; the other eight patients required dual treatment with a PPI plus the prokinetic acotiamide. Early satiety tended to be relieved after the dual treatment, but the improvement was not significant. Thus, in patients with dyspepsia and an H. pylori infection, the H. pylori should be eradicated first. The administration of a PPI is useful in patients with GERD symptoms, and a PPI+ acotiamide may be beneficial for residual symptoms of early satiety. |
| Keywords | 機能性ディスペプシア (functional dyspepsia) ヘリコバクター・ピロリ (Helicobacter pylori) プロトンポンプ阻害剤 (proton pomp inhibitor) 消化管運動機能改善剤 (acotiamide) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2019-12-02 |
| Volume | volume131 |
| Issue | issue3 |
| Start Page | 139 |
| End Page | 143 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.131.139 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2019 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.131.139 |
| NAID | 130007782646 |
| Title Alternative | The 2018 Incentive Award of the Okayama Medical Association in Cancer Research (2018 Hayashibara Prize and Yamada Prize) |
|---|---|
| FullText URL | 131_127.pdf |
| Author | Kato, Takuya| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2019-12-02 |
| Volume | volume131 |
| Issue | issue3 |
| Start Page | 127 |
| End Page | 130 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.131.127 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2019 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.131.127 |
| NAID | 130007782637 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uchida, Daisuke| Kato, Hironari| Matsumoto, Kazuyuki| Ishihara, Yuki| Matsumi, Akihiro| Saragai, Yosuke| Takada, Saimon| Yabe, Shuntaro| Muro, Shinichiro| Tomoda, Takeshi| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Keywords | Endoscopic ultrasound Diagnostic screening program Pancreatic diseases Biliary tract diseases |
| Published Date | 2019-12-18 |
| Publication Title | BMC Gastroenterology |
| Volume | volume19 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 220 |
| ISSN | 1471-230X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2019 |
| File Version | publisher |
| PubMed ID | 31852458 |
| DOI | 10.1186/s12876-019-1141-7 |
| Web of Science KeyUT | 000510482800002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12876-019-1141-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takagi, Kosei| Domagala, Piotr| Polak, Wojciech G.| Buettner, Stefan| Ijzermans, Jan N. M.| |
| Keywords | Controlling nutritional status (CONUT) score Hepatocellular carcinoma Outcome Meta-analysis |
| Published Date | 2019-12-09 |
| Publication Title | BMC Gastroenterology |
| Volume | volume19 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 211 |
| ISSN | 1471-230X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2019 |
| File Version | publisher |
| PubMed ID | 31818259 |
| DOI | 10.1186/s12876-019-1126-6 |
| Web of Science KeyUT | 000510482200001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12876-019-1126-6 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yoshioka, Takahiro| Shien, Kazuhiko| Takeda, Tatsuaki| Takahashi, Yuta| Kurihara, Eisuke| Ogoshi, Yusuke| Namba, Kei| Torigoe, Hidejiro| Sato, Hiroki| Tomida, Shuta| Yamamoto, Hiromasa| Soh, Junichi| Fujiwara, Toshiyoshi| Toyooka, Shinichi| |
| Keywords | afatinib gastric cancer HER2 MET YES1 |
| Published Date | 2019-06-04 |
| Publication Title | Cancer Science |
| Volume | volume110 |
| Issue | issue8 |
| Publisher | Wiley Open Access |
| Start Page | 2549 |
| End Page | 2557 |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 31162771 |
| DOI | 10.1111/cas.14089 |
| Web of Science KeyUT | 000478616800022 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.14089 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yasutomi, Eriko| Hiraoka, Sakiko| Yamamoto, Shumpei| Oka, Shohei| Hirai, Mami| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Takahara, Masahiro| Harada, Keita| Kato, Jun| Okada, Hiroyuki| |
| Keywords | ulcerative colitis salicylates mesalazine sulfasalazine |
| Published Date | 2019-12-02 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume8 |
| Issue | issue12 |
| Publisher | MDPI |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31810227 |
| DOI | 10.3390/jcm8122109 |
| Web of Science KeyUT | 000506640400082 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm8122109 |
| JaLCDOI | 10.18926/AMO/57950 |
|---|---|
| FullText URL | 74_1_33.pdf |
| Author | Honda, Hiroyuki| Hanayama, Yoshihisa| Obika, Mikako| Hasegawa, Kou| Hamahara, Jun| Kishida, Masayuki| Hagiya, Hideharu| Ogawa, Hiroko| Kataoka, Hitomi| Otsuka, Fumio| |
| Abstract | A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients’ gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups’ characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients’ SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients’ PPG levels were correlated with GERD-related symptoms, diabetic patients’ blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful |
| Keywords | blood glucose type 2 diabetes mellitus gastroesophageal reflux depressive status postprandial plasma glucose |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 33 |
| End Page | 40 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099246 |
| Web of Science KeyUT | 000516606200005 |
| NAID | 120006795617 |
| JaLCDOI | 10.18926/AMO/57946 |
|---|---|
| FullText URL | 74_1_1.pdf |
| Author | Chen, Yuehua| Ohara, Toshiaki| Xing, Boyi| Qi, Jiping| Noma, Kazuhiro| Matsukawa, Akihiro| |
| Abstract | Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings. |
| Keywords | cancer stem cell stemness iron chelation chemotherapy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099242 |
| Web of Science KeyUT | 000516606200001 |
| NAID | 120006795613 |
