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Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression
FullText URL fulltext.pdf
Author Tanimoto, Terutaka| Tazawa, Hiroshi| Ieda, Takeshi| Nouso, Hiroshi| Tani, Morimichi| Oyama, Takanori| Urata, Yasuo| Kagawa, Shunsuke| Noda, Takuo| Fujiwara, Toshiyoshi|
Keywords neuroblastoma MYCN hTERT adenovirus E2F1
Published Date 2020-09-25
Publication Title Molecular Therapy - Oncolytics
Volume volume18
Publisher Cell Press
Start Page 14
End Page 23
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32637577
DOI 10.1016/j.omto.2020.05.015
Web of Science KeyUT 000575168700002
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.05.015
Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer
FullText URL fulltext.pdf
Author Ishikawa, Wataru| Kikuchi, Satoru| Ogawa, Toshihiro| Tabuchi, Motoyasu| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords peritoneal metastasis adenovirus gastric cancer intraperitoneal chemotherapy paclitaxel oncolytic virus
Published Date 2020-09-25
Publication Title Molecular Therapy - Oncolytics
Volume volume18
Publisher Cell Press
Start Page 262
End Page 271
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32728614
DOI 10.1016/j.omto.2020.06.021
Web of Science KeyUT 000575168700023
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.06.021
Comprehensive Prospective Analysis of the Factors Contributing to Aspiration Pneumonia Following Endoscopic Submucosal Dissection in Patients with Early Gastric Neoplasms
JaLCDOI 10.18926/AMO/60800
FullText URL 74_5_407.pdf
Author Togo, Masaaki| Akazawa, Yuko| Akashi, Taro| Yamashita, Rika| Yoshitomi, Izumi| Ohba, Kazuo| Hashimoto, Satsuki| Iwashita, Hiroko| Kurogi, Tadafumi| Osada, Yukiko| Wada, Noriko| Imamura, Yoshifumi| Hashiguchi, Keiichi| Yamaguchi, Naoyuki| Kondo, Hisayoshi| Nakao, Kazuhiko|
Abstract Endoscopic submucosal dissection (ESD) has become the first-line treatment for early gastric neoplasms; however, a subset of patients treated by this method develop aspiration pneumonia. We conducted a comprehensive prospective analysis of the factors contributing to post-ESD aspiration pneumonia in early gastric neoplasms in this study, with special focus on whether pre-treatment oral care can prevent aspiration pneumonia. Sixty-one patients who underwent ESD for gastric neoplasms were randomly assigned to the oral care or control groups. ESD was performed under deep sedation. Of 60 patients whose data were available for analysis, 5 (8.3%) experienced pneumonia confirmed either by chest radiography or computed tomography. Although no difference in the rate of pneumonia was found between the control and oral care groups, the post-oral care bacteria count was significantly higher in the saliva of patients who developed pneumonia compared to those without pneumonia. In addition, the presence of vascular brain diseases and the dose of meperidine were also significantly associated with the occurrence of pneumonia. These results suggest that the number of oral bacteria as well as pre-existing vascular brain diseases and high-dose narcotics can affect the incidence of post-ESD pneumonia.
Keywords endoscopy oral bacteria respiratory disease pneumonia sedation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-10
Volume volume74
Issue issue5
Publisher Okayama University Medical School
Start Page 407
End Page 413
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33106696
Web of Science KeyUT 000581970100005
NAID 120006892926
Efficacy of surgical management for recurrent intrahepatic cholangiocarcinoma: A multi-institutional study by the Okayama Study Group of HBP surgery
FullText URL fulltext.pdf
Author Kojima, Toru| Umeda, Yuzo| Fuji, Tomokazu| Niguma, Takefumi| Satoh, Daisuke| Endo, Yoshikatsu| Sui, Kenta| Inagaki, Masaru| Oishi, Masahiro| Ota, Tetsuya| Hioki, Katsuyoshi| Matsuda, Tadakazu| Aoki, Hideki| Hirai, Ryuji| Kimura, Masashi| Yagi, Takahito| Fujiwara, Toshiyoshi|
Published Date 2020-09-03
Publication Title PLOS ONE
Volume volume15
Issue issue9
Publisher PUBLIC LIBRARY SCIENCE
Start Page e0238392
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Kojima et al.
File Version publisher
PubMed ID 32881910
DOI 10.1371/journal.pone.0238392
Web of Science KeyUT 000571063300054
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0238392
Utility of Endoscopic Ultrasound-Guided Fine Needle Aspiration in the Diagnosis of Local Recurrence of Pancreaticobiliary Cancer after Surgical Resection
FullText URL fulltext.pdf
Author Matsumoto, Kazuyuki| Kato, Hironari| Horiguchi, Shigeru| Tomoda, Takeshi| Matsumi, Akihiro| Ishihara, Yuki| Saragai, Yosuke| Takada, Saimon| Muro, Shinichiro| Uchida, Daisuke| Okada, Hiroyuki|
Keywords Endoscopic ultrasound-guided fine needle aspiration Pancreaticobiliary cancer Neoplasm recurrence
Published Date 2020
Publication Title Gut and Liver
Volume volume14
Issue issue5
Publisher Gut and Liver
Start Page 652
End Page 658
ISSN 1976-2283
NCID AA12329814
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 31818050
NAID 120006891207
DOI 10.5009/gnl19200
Web of Science KeyUT 000569359000016
Related Url isVersionOf https://doi.org/10.5009/gnl19200
Prediction of the prognosis of advanced hepatocellular carcinoma by TERT promoter mutations in circulating tumor DNA
FullText URL fulltext.pdf
Author Hirai, Mami| Kinugasa, Hideaki| Nouso, Kazuhiro| Yamamoto, Shumpei| Terasawa, Hiroyuki| Onishi, Yuma| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Sakata, Masahiro| Yasunaka, Tetsuya| Onishi, Hideki| Shiraha, Hidenori| Takaki, Akinobu| Okada, Hiroyuki|
Keywords ctDNA hepatocellular carcinoma liquid biopsy prediction prognosis TERT promoter mutation
Published Date 2020-08-24
Publication Title Journal of Gastroenterology and Hepatology
Volume volume36
Publisher Wiley
Start Page 1118
End Page 1125
ISSN 0815-9319
NCID AA10727383
Content Type Journal Article
File Version author
PubMed ID 32830343
DOI 10.1111/jgh.15227
Web of Science KeyUT 000568136400001
Related Url isVersionOf https://doi.org/10.1111/jgh.15227
Gastric Adenocarcinoma and Proximal Polyposis of the Stomach Occurring With Ball Valve Syndrome
FullText URL fulltext.pdf Figure_A.tif Figure_B.tif Figure_C.tif Figure_D.tif
Author Ako, Soichiro| Kawano, Seiji| Okada, Hiroyuki|
Published Date 2020-07-23
Publication Title Clinical Gastroenterology and Hepatology
Volume volume20
Issue issue2
Publisher AGA Institute
Start Page e12
End Page e13
ISSN 15423565
NCID AA11845942
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the AGA Institute
File Version author
PubMed ID 32712389
DOI 10.1016/j.cgh.2020.07.044
Related Url isVersionOf https://doi.org/10.1016/j.cgh.2020.07.044
Learning curve of kidney transplantation in a high-volume center: A Cohort study of 1466 consecutive recipients
FullText URL fulltext.pdf
Author Takagi, Kosei| Outmani, Loubna| Kimenai, Hendrikus J.A.N.| Terkivatan, Turkan| Tran, Khe T.C.| Ijzermans, Jan N.M.| Minnee, Robert C.|
Keywords Kidney transplantation Surgeon volume Outcome Cumulative sum analysis Learning curve
Published Date 2020-08
Publication Title International Journal of Surgery
Volume volume80
Publisher Elsevier
Start Page 129
End Page 134
ISSN 1743-9191
NCID AA12063080
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32659389
DOI 10.1016/j.ijsu.2020.06.047
Web of Science KeyUT 000561153700036
Related Url isVersionOf https://doi.org/10.1016/j.ijsu.2020.06.047
Pulmonary resection for metachronous metastatic gastric cancer diagnosed using multi-detector computed tomography: Report of five cases
FullText URL fulltext.pdf
Author Nishiwaki, Noriyuki| Kojima, Hideaki| Isaka, Mitsuhiro| Bando, Etsuro| Terashima, Masanori| Ohde, Yasuhisa|
Keywords Gastric cancer Pulmonary metastasis Pulmonary resection
Published Date 2020-07-24
Publication Title International Journal of Surgery Case Reports
Volume volume73
Publisher Elsevier
Start Page 342
End Page 346
ISSN 2210-2612
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 32739523
DOI 10.1016/j.ijscr.2020.07.062
Web of Science KeyUT 000558789800023
Related Url isVersionOf https://doi.org/10.1016/j.ijscr.2020.07.062
Laparoscopic liver resection of segment seven: A case report and review of surgical techniques
FullText URL fulltext.pdf
Author Takagi, Kosei| Kuise, Takashi| Umeda, Yuzo| Yoshida, Ryuichi| Teraishi, Fuminori| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Laparoscopic Liver Segment seven
Published Date 2020
Publication Title International Journal of Surgery Case Reports
Volume volume73
Publisher Elsevier
Start Page 168
End Page 171
ISSN 2210-2612
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32688239
DOI 10.1016/j.ijscr.2020.06.107
Web of Science KeyUT 000558775100010
Related Url isVersionOf https://doi.org/10.1016/j.ijscr.2020.06.107
Decreased Serum Antioxidant Marker is Predictive of Early Recurrence in the Same Segment after Radical Ablation for Hepatocellular Carcinoma
JaLCDOI 10.18926/AMO/60364
FullText URL 74_4_275.pdf
Author Muro, Taiko| Nakamura, Shinichiro| Takaki, Akinobu| Onishi, Hideki| Wada, Nozomu| Yasunaka, Tetsuya| Uchida, Daisuke| Oyama, Atsushi| Adachi, Takuya| Shiraha, Hidenori| Okada, Hiroyuki|
Abstract Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment.
Keywords oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 275
End Page 283
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843758
Web of Science KeyUT 000562508700002
NAID 120006880203
Factors Predicting a Favorable Disease Course Without Anti-TNF Therapy in Crohn’s Disease Patients
JaLCDOI 10.18926/AMO/60363
FullText URL 74_4_265.pdf
Author Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun|
Abstract Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy.
Keywords Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 265
End Page 274
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843757
Web of Science KeyUT 000562508700001
NAID 120006880202
Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma
FullText URL fulltext.pdf
Author Uchida, Daisuke| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Okada, Hiroyuki|
Keywords oxidative stress chronic hepatitis hepatocellular carcinoma
Published Date 2020-05-28
Publication Title Nutrients
Volume volume12
Issue issue6
Publisher MDPI
Start Page 1576
ISSN 2072-6643
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32481552
DOI 10.3390/nu12061576
Web of Science KeyUT 000554005200001
Related Url isVersionOf https://doi.org/10.3390/nu12061576
Nivolumab-induced IgA nephropathy in a patient with advanced gastric cancer A case report
FullText URL fulltext.pdf
Author Tanabe, Katsuyuki| Kanzaki, Hiromitsu| Wada, Takahira| Nakashima, Yuri| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun|
Keywords case report gastric cancer IgA nephropathy nivolumab steroid
Published Date 2020-05-22
Publication Title Medicine
Volume volume99
Issue issue21
Publisher Lippincott, Williams & Wilkins
Start Page e20464
ISSN 0025-7974
NCID AA00728867
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 the Author(s).
File Version publisher
PubMed ID 32481351
DOI 10.1097/MD.0000000000020464
Web of Science KeyUT 000551508200106
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000020464
The Early Decline of alpha-Fetoprotein and Des-gamma-Carboxy Prothrombin Predicts the Response of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients
FullText URL fulltext.pdf
Author Yamamoto, Shumpei| Onishi, Hideki| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Sakata, Masahiro| Yasunaka, Tetsuya| Shiraha, Hidenori| Okada, Hiroyuki|
Keywords Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Low-dose cisplatin plus 5-fluorouracil alpha-Fetoprotein Des-gamma-carboxy prothrombin
Published Date 2020-04-21
Publication Title Gastrointestinal Tumors
Volume volume7
Issue issue3
Publisher Karger
Start Page 83
End Page 92
ISSN 2296-3774
NCID AA12665877
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s)
File Version publisher
DOI 10.1159/000506941
Web of Science KeyUT 000551254300003
Related Url isVersionOf https://doi.org/10.1159/000506941
第32回日本バイオセラピィ学会学術集会総会報告
Title Alternative The 32th Annual Meeting of the Japan Society for Biological Therapy
FullText URL 132_41.pdf
Author Fujiwara, Toshiyoshi|
Publication Title Journal of Okayama Medical Association
Published Date 2020-04-01
Volume volume132
Issue issue1
Start Page 41
End Page 43
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.132.41
language Japanese
Copyright Holders Copyright (c) 2020 岡山医学会
File Version publisher
DOI 10.4044/joma.132.41
NAID 130007840310
平成30年度岡山医学会賞 総合研究奨励賞（結城賞）
Title Alternative The 2018 Incentive Award of the Okayama Medical Association in General Medical Science (2018 Yuuki Prize)
FullText URL 132_7.pdf
Author Kita, Masahide|
Publication Title Journal of Okayama Medical Association
Published Date 2020-04-01
Volume volume132
Issue issue1
Start Page 7
End Page 9
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.132.7
language Japanese
Copyright Holders Copyright (c) 2020 岡山医学会
File Version publisher
DOI 10.4044/joma.132.7
NAID 130007840308
Skeletal muscle loss in the postoperative acute phase after esophageal cancer surgery as a new prognostic factor
FullText URL fulltext.pdf
Author Maeda, Naoaki| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi|
Published Date 2020-06-26
Publication Title World Journal of Surgical Oncology
Volume volume18
Issue issue1
Publisher BMC
Start Page 143
ISSN 1477-7819
NCID AA12048269
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32591002
DOI 10.1186/s12957-020-01908-6
Web of Science KeyUT 000545948700003
Related Url isVersionOf https://doi.org/10.1186/s12957-020-01908-6
Emergent cholecystectomy in patients on antithrombotic therapy
FullText URL fulltext.pdf
Author Yoshimoto, Masashi| Hioki, Masayoshi| Sadamori, Hiroshi| Monden, Kazuteru| Ohno, Satoshi| Takakura, Norihisa|
Keywords Cholecystitis
Published Date 2020-06-22
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 10122
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32572122
DOI 10.1038/s41598-020-67272-3
Web of Science KeyUT 000543969500023
Related Url isVersionOf https://doi.org/10.1038/s41598-020-67272-3
Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer
FullText URL fulltext.pdf
Author Koujima, Takeshi| Tazawa, Hiroshi| Ieda, Takeshi| Araki, Hiroyuki| Fushimi, Takuro| Shoji, Ryohei| Kuroda, Shinji| Kikuchi, Satoru| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Urata, Yasuo| Mizuguchi, Hiroyuki| Fujiwara, Toshiyoshi|
Published Date 2020-06-26
Publication Title Molecular Therapy - Oncolytics
Volume volume17
Publisher Cell Press
Start Page 107
End Page 117
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32322667
DOI 10.1016/j.omto.2020.03.016
Web of Science KeyUT 000544101600010
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.03.016
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