result 627 件
FullText URL | cancers_11_2_177.pdf |
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Author | Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi| |
Keywords | cancer stem cells combination therapy iron stemness |
Published Date | 2019-02-03 |
Publication Title | Cancers |
Volume | volume11 |
Issue | issue2 |
Publisher | MDPI |
Start Page | 177 |
ISSN | 2072-6694 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 by the authors |
File Version | publisher |
PubMed ID | 30717462 |
DOI | 10.3390/cancers11020177 |
Web of Science KeyUT | 000460747200051 |
Related Url | isVersionOf https://doi.org/10.3390/cancers11020177 |
FullText URL | JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg |
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Author | Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Tanaka, Noriyuki| Kato, Hironari| Horiguchi, Shigeru| Yoshida, Ryuichi| Umeda, Yuzo| Fushimi, Soichiro| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki| |
Keywords | Immunohistochemistry PD-L1 Pancreatic cancer |
Note | This fulltext will be available in Apr 2020| |
Published Date | 2019-04-29 |
Publication Title | Journal of Gastroenterology |
Volume | volume54 |
Issue | issue11 |
Start Page | 1019 |
End Page | 1028 |
ISSN | 09441174 |
NCID | AA10988015 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 31032528 |
DOI | 10.1007/s00535-019-01586-6 |
Web of Science KeyUT | 000492169400008 |
Related Url | isVersionOf https://doi.org/10.1007/s00535-019-01586-6 |
FullText URL | OncoImmunol_8_12_1671760.pdf |
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Author | Sakamoto, Shuichi| Kagawa, Shunsuke| Kuwada, Kazuya| Ito, Atene| Kajioka, Hiroki| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kagawa, Tetsuya| Yoshida, Ryuichi| Kikuchi, Satoru| Kuroda, Shinji| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
Keywords | Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination |
Published Date | 2019-10-22 |
Publication Title | OncoImmunology |
Volume | volume8 |
Issue | issue12 |
Publisher | TAYLOR & FRANCIS |
Start Page | e1671760 |
ISSN | 2162402X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Author(s). |
File Version | publisher |
DOI | 10.1080/2162402X.2019.1671760 |
Web of Science KeyUT | 000494085400001 |
Related Url | isVersionOf https://doi.org/10.1080/2162402X.2019.1671760 |
FullText URL | AnnGastroenterolSurg_3_4_396.pdf |
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Author | Fujiwara, Toshiyoshi| |
Keywords | adenovirus clinical trial esophageal cancer radiotherapy telomerase |
Published Date | 2019-07-05 |
Publication Title | Annals of gastroenterological surgery |
Volume | volume3 |
Issue | issue4 |
Publisher | John Wiley & Sons |
Start Page | 396 |
End Page | 404 |
ISSN | 24750328 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors |
File Version | publisher |
PubMed ID | 31346579 |
DOI | 10.1002/ags3.12270 |
Web of Science KeyUT | 000475745100009 |
Related Url | isVersionOf https://doi.org/10.1002/ags3.12270 |
FullText URL | Esophagus_16_3_300.pdf Fig.pdf |
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Author | Yokoi, Aya| Ekuni, Daisuke| Yamanaka, Reiko| Hata, Hironobu| Shirakawa, Yasuhiro| Morita, Manabu| |
Keywords | Deglutition Deglutition disorders Esophageal neoplasms Esophagectomy Intensive care units |
Published Date | 2019-04-02 |
Publication Title | Esophagus |
Volume | volume16 |
Issue | issue3 |
Publisher | Springer Singapore |
Start Page | 300 |
End Page | 308 |
ISSN | 16129059 |
NCID | AA11885266 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 30941604 |
DOI | 10.1007/s10388-019-00668-x |
Related Url | isVersionOf https://doi.org/10.1007/s10388-019-00668-x |
JaLCDOI | 10.18926/AMO/57377 |
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FullText URL | 73_5_457.pdf |
Author | Iwamuro, Masaya| Takahara, Masahiro| Yamazaki, Tatsuhiro| Tanaka, Takehiro| Kondo, Yoshitaka| Hiraoka, Sakiko| Okada, Hiroyuki| |
Abstract | A 60-year-old Caucasian male was diagnosed with lung adenocarcinoma and multiple metastases to the bone, spleen, and brain. He underwent radiotherapy for the brain and lumbar spine metastases, plus chemotherapy (cisplatin and pemetrexed). The chemotherapy was discontinued due to vomiting and hyponatremia, and nivolumab was then administered. Eight months later, 18F-fluorodeoxyglucose positron emission tomography showed tracer uptake in the colon. Colonoscopy revealed a reddish multinodular polyp in the sigmoid colon. The polyp showed irregular microvessels. No colonic mucosal surface structures were observed. Colonic metastasis of the lung carcinoma was highly suspected; the polyp was therefore surgically removed. The histological analysis revealed granulation tissue and suppurative inflammation without neoplastic changes. We diagnosed the lesion as a granulation polyp. Despite the difficulty in diagnosing these lesions due to their rarity and similarity to metastatic colon tumors, we suggest that recognizing the endoscopic features of the polyp surface may allow a preoperative diagnosis. |
Keywords | colonoscopy colonic neoplasms granulation polyp |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2019-10 |
Volume | volume73 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 457 |
End Page | 461 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 31649373 |
Web of Science KeyUT | 000491886600012 |
FullText URL | Gastroenterology156_6_1753.pdf fig.pdf |
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Author | Tomoda, Takeshi| Kato, Hironari| Ueki, Toru| Akimoto, Yutaka| Hata, Hidenori| Fujii, Masakuni| Harada, Ryo| Ogawa, Tsuneyoshi| Wato, Masaki| Takatani, Masahiro| Matsubara, Minoru| Kawai, Yoshinari| Okada, Hiroyuki| |
Keywords | Drug Inflammation Pancreas Smooth-Muscle Relaxant |
Published Date | 2019-05-31 |
Publication Title | Gastroenterology |
Volume | volume156 |
Issue | issue6 |
Publisher | W B SAUNDERS CO-ELSEVIER |
Start Page | 1753 |
End Page | 1760 |
ISSN | 00165085 |
NCID | AA0065394X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 30772342 |
DOI | 10.1053/j.gastro.2019.01.267 |
Web of Science KeyUT | 10.1053/j.gastro.2019.01.267 |
Related Url | isVersionOf https://doi.org/10.1053/j.gastro.2019.01.267 |
FullText URL | CGH17_6_56.pdf fig.pdf |
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Author | Tomoda, Takeshi| Kato, Hironari| Okada, Hiroyuki| |
Published Date | 2019-05-31 |
Publication Title | Clinical Gastroenterology and Hepatology |
Volume | volume17 |
Issue | issue6 |
Publisher | Elsevier Science |
Start Page | e56 |
End Page | e57 |
ISSN | 15423565 |
NCID | AA11845942 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 by the AGA Institute |
File Version | author |
PubMed ID | 29857148 |
DOI | 10.1016/j.cgh.2018.05.032 |
Web of Science KeyUT | 000464657100006 |
Related Url | isVersionOf https://doi.org/10.1016/j.cgh.2018.05.032 |
FullText URL | DLD51_1_168.pdf |
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Author | Iwamuro, Masaya| Urata, Haruo| Tanaka, Takehiro| Okada, Hiroyuki| |
Published Date | 2019-01-31 |
Publication Title | Digestive and Liver Disease |
Volume | volume51 |
Issue | issue1 |
Publisher | Elsevier |
Start Page | 168 |
ISSN | 15908658 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
File Version | author |
PubMed ID | 30145054 |
DOI | 10.1016/j.dld.2018.07.031 |
Web of Science KeyUT | 000454119300026 |
Related Url | isVersionOf https://doi.org/10.1016/j.dld.2018.07.031 |
Title Alternative | The 2017 Incentive Award of the Okayama Medical Association in Cancer Research (2017 Hayashibara Prize and Yamada Prize) |
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FullText URL | 131_5.pdf |
Author | Sakae, Hiroyuki| |
Publication Title | Journal of Okayama Medical Association |
Published Date | 2019-04-01 |
Volume | volume131 |
Issue | issue1 |
Start Page | 5 |
End Page | 7 |
ISSN | 0030-1558 |
Related Url | isVersionOf https://doi.org/10.4044/joma.131.5 |
language | Japanese |
Copyright Holders | Copyright (c) 2019 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.131.5 |
NAID | 130007642651 |
JaLCDOI | 10.18926/AMO/56940 |
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FullText URL | 73_4_367.pdf |
Author | Mifune-Morioka, Tomoyo| A. Uchida, Haruhito| Fukushima, Kazuhiko| Watanabe, Mayu| Ouchi, Chihiro| Mise, Koki| Kawakita, Chieko| Kano, Yuzuki| Onishi, Akifumi| Toma, Kishio| Eguchi, Jun| Wada, Nozomu| Ikeda, Fusao| Sasaki, Erika| Suganami, Yu| Kishida, Masayuki| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun| |
Abstract | Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored. |
Keywords | autoimmune polyglandular syndrome type 3 systemic lupus erythematosus autoimmune hepatitis slowly progressive insulin-dependent diabetes mellitus chronic thyroiditis |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2019-08 |
Volume | volume73 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 367 |
End Page | 372 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 31439961 |
JaLCDOI | 10.18926/AMO/56939 |
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FullText URL | 73_4_361.pdf |
Author | Watanabe, Ayako| Kadowaki, Yoshihiko| Hattori, Kenji| Ohmori, Mika| Tsukayama, Hiroyuki| Kubota, Nobuhito| Okumoto, Tatsuo| Ishido, Nobuhiro| Okino, Takeshi| |
Abstract | A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely similar to phlebosclerotic colitis in clinical findings; surgical resection was required for correct diagnosis. |
Keywords | phlebosclerotic colitis colorectal cancer signet ring cell carcinoma young colorectal cancer |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2019-08 |
Volume | volume73 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 361 |
End Page | 365 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 31439960 |
JaLCDOI | 10.18926/AMO/56935 |
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FullText URL | 73_4_333.pdf |
Author | Kuwaki, Kenji| Nouso, Kazuhiro| Miyashita, Manabi| Makino, Yasuhiro| Hagihara, Hiroaki| Moriya, Akio| Adachi, Takuya| Wada, Nozomu| Yasunaka, Yuki| Yasunaka, Tetsuya| Takeuchi, Yasuto| Onishi, Hideki| Nakamura, Shinichiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Okada, Hiroyuki| |
Abstract | Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) after TACE was significantly less in the steroid group (56/21/0) compared to the control group (35/29/3, p=0.005, Cochran-Armitage test for trend). The suppressive effect of steroids against fever was prominent in females (p=0.001). Vomiting (G0/G1/ G2-) was also less frequent in the steroid group (70/5/2) versus the control group (53/10/3), but not significantly (p=0.106). The algetic degree and the grade of hematological adverse events, including hyperglycemia, did not differ between the groups. We conclude that the administration of steroids was useful for the prevention of adverse events after TACE in patients with HCC. |
Keywords | antipyretic hepatocellular carcinoma therapeutic chemoembolization steroid |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2019-08 |
Volume | volume73 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 333 |
End Page | 339 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 31439956 |
JaLCDOI | 10.18926/AMO/56862 |
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FullText URL | 73_3_205.pdf |
Author | Mukai, Yuko| Sakurai, Toru| Watanabe, Toshiyuki| Sako, Tomoko| Sugimoto, Morito| Kimata, Yoshihiro| Mori, Yoshiko| Nagasaka, Takeshi| Namba, Yuzaburo| |
Abstract | Intestinal vaginoplasty has several advantageous features, such as scarless surgery, low incidence of contraction of the reconstructed vagina, maintenance of vaginal depth, spontaneous mucus production, and a low rate of complications. Therefore, this technique is becoming popular in many countries. Following the global trend, the demand for intestinal vaginoplasty for transsexuals is also increasing in Japan. However, there are few reports on intestinal vaginoplasty in Japan. In this study, we examined the safety and effectiveness of rectosigmoid colon vaginoplasty in the Japanese population. We retrospectively surveyed 18 male-to-female transsexuals who underwent laparoscopic rectosigmoid colon vaginoplasty at the Okayama University Hospital Gender Center between October 2012 and December 2017. One patient had developed an anastomotic leak and 2 patients experienced vaginal prolapse, which needed revision surgery. Both adverse outcomes were comparable with those from previous studies. The anastomotic leak was managed adequately with conservative treatment. To avoid vaginal prolapse, it is important to decide the length of the rectosigmoid segment so that a pull on it does not cause it to become lax, while excessive stress on the feeder vessels is avoided. Based on our study, we concluded that rectosigmoid vaginoplasty was a reliable technique in the Japanese population. |
Keywords | vaginoplasty male-to-female transsexuals rectosigmoid colon |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2019-06 |
Volume | volume73 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 205 |
End Page | 211 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 31235967 |
FullText URL | K0005903_abstract_review.pdf K0005903_summary.pdf K0005903_fulltext.pdf K0005903_Figure.pdf |
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Author | Adachi, Takuya| |
Published Date | 2019-03-25 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5903号 |
Granted Date | 2019-03-25 |
Thesis Type | Doctor of Philosophy in Medical Science |
Grantor | 岡山大学 |
language | English |
JaLCDOI | 10.18926/AMO/56646 |
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FullText URL | 73_2_109.pdf |
Author | Abe, Makoto| Iwamuro, Masaya| Kawahara, Yoshiro| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Tsumura, Munechika| Makino, Takuma| Noda, Yohei| Marunaka, Hidenori| Nishizaki, Kazunori| Okada, Hiroyuki| |
Abstract | The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. “Resect and watch” is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer. |
Keywords | endoscopic submucosal dissection superficial cancer pharynx endoscopic resection |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2019-04 |
Volume | volume73 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 109 |
End Page | 115 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 31015745 |
Title Alternative | Video capsule endoscopy usage: Intra-hospital consultations before and after the expansion of indications |
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FullText URL | 130_155.pdf |
Author | Kawano, Seiji| Iwamuro, Masaya| Inokuchi, Toshihiro| Sugihara, Yuusaku| Harada, Keita| Hiraoka, Sakiko| Okada, Hiroyuki| |
Abstract | Approximately 10 years have passed since video capsule endoscopy (VCE)was introduced in routine clinical practice in Japan. We started using VCE in January 2009. Here we investigated the contribution of VCE and its level of recognition at our 855-bed hospital. We compared the clinical characteristics of intra-hospital consultation cases with non-consultation cases, and the details of the cases from each of our hospital’s departments. The number of intra-hospital consultations was notably increased by our expansion of the indications for non-obscure gastrointestinal bleeding (OGIB)cases. However, most of our hospital’s departments are sub-departments of internal medicine, in which almost no change in indications has been made. We found that the percentage of OGIB cases was higher among the intra-hospital consultations than non-consultations, and that the OGIB percentages differed markedly among the departments. Especially for OGIB cases, all hospital departments should be better informed regarding the indications for and efficacy of VCE. |
Keywords | カプセル内視鏡(video capsule endoscopy) 適応拡大(expansion of indication) 院内紹介(intra-hospital consultation) |
Publication Title | Journal of Okayama Medical Association |
Published Date | 2018-12-03 |
Volume | volume130 |
Issue | issue3 |
Start Page | 155 |
End Page | 159 |
ISSN | 0030-1558 |
Related Url | isVersionOf https://doi.org/10.4044/joma.130.147 |
language | Japanese |
Copyright Holders | Copyright (c) 2018 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.130.147 |
NAID | 130007542857 |
JaLCDOI | 10.18926/AMO/56463 |
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FullText URL | 73_1_81.pdf |
Author | Sugihara, Yuusaku| Harada, Keita| Oka, Shohei| Yasutomi, Eriko| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Takahara, Masahiro| Hiraoka, Sakiko| Otsuka, Fumio| Okada, Hiroyuki| |
Abstract | Endoscopic submucosal dissection (ESD) is reportedly one of the standard treatment strategies for large superficial colorectal neoplasms in Japan because of its high en bloc resection rate. A few technical issues regarding ESD should be considered, one of which is the selection of the Endo-cut I mode versus the Swift-coagulation mode as the electrosurgical unit mode setting during submucosal dissection. We seek to determine which of these two modes is more suitable for submucosal dissections of colorectal tumors with regard to procedure time and safety. |
Keywords | endoscopic submucosal dissection electrosurgical mode colorectal tumor |
Amo Type | Clinical Study Protocol |
Publication Title | Acta Medica Okayama |
Published Date | 2019-02 |
Volume | volume73 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 81 |
End Page | 84 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 30820059 |
JaLCDOI | 10.18926/AMO/56462 |
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FullText URL | 73_1_77.pdf |
Author | Morita, Mio| Matsumoto, Hiroshi| Shirakawa, Yasuhiro| Noma, Kazuhiro| Tanabe, Shunsuke| Kimata, Yoshihiro| |
Abstract | Anterior cervical plate fixation is a common surgical treatment for cervical spine trauma, disc herniation, or cervical spondylosis. Esophageal perforation following anterior cervical plate fixation is a rare but serious complication. Management of esophageal perforation is controversial; however, we suggest treating most cases surgically because this condition is slow to heal and often fatal. We managed 2 cases of esophageal perforation following anterior cervical plate fixation by flap reconstruction with the pectoralis major muscle in one case and a jejunal free flap in the other. Here, we report our experience and review the surgical indications. |
Keywords | anterior cervical plate fixation esophageal perforation reconstruction pectoralis major flap jejunal free flap |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2019-02 |
Volume | volume73 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 77 |
End Page | 80 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 30820058 |
JaLCDOI | 10.18926/AMO/56457 |
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FullText URL | 73_1_43.pdf |
Author | Ikeda, Ailee| Takaki, Akinobu| Yasunaka, Tetsuya| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Ikeda, Fusao| Shiraha, Hidenori| Yoshida, Kazuhiro| Kuise, Takashi| Nobuoka, Daisuke| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Fujiwara, Toshiyoshi| Okada, Hiroyuki| |
Abstract | Post-orthotopic liver transplantation (OLT) hepatitis B recurrence is well-controlled with a nucleos(t)ide analogue and hepatitis B immunoglobulin (HBIG) combination, but the high cost and the potential risk of unknown infection associated with HBIG remain unresolved issues. Low-cost recombinant hepatitis B virus (HBV) vaccine administration is a potential solution to these problems. We retrospectively analyzed the rate and predictive factors of HBV vaccine success in 49 post-OLT patients: liver cirrhosis-type B (LC-B), n=28 patients; acute liver failure-type B (ALF-B), n=8; and non-HBV-related end-stage liver disease (non-B ESLD) who received a liver from anti-hepatitis B core antibody-positive donors, n=13. A positive anti-hepatitis B surface antibody response was achieved in 29% (8/28) of the LC-B group, 88% (7/8) of the ALF-B group, and 44% (4/9) of the adult non-B ESLD group. All four non-B ESLD infants showed vaccine success. The predictive factors for a good response in LC-B were young age, marital donor, and high donor age. ALF-B and non-B ESLD infants are thus good vaccination candidates. LC-B patients with marital donors are also good candidates, perhaps because the donated liver maintains an efficient immune memory to HBV, as the donors had already been infected in adulthood and showed adequate anti-HBV immune responses. |
Keywords | acute liver failure hepatitis B hepatitis B vaccine liver cirrhosis liver transplantation |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2019-02 |
Volume | volume73 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 41 |
End Page | 50 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 30820053 |