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FullText URL cancers_11_2_177.pdf
Author Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi|
Keywords cancer stem cells combination therapy iron stemness
Published Date 2019-02-03
Publication Title Cancers
Volume volume11
Issue issue2
Publisher MDPI
Start Page 177
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors
File Version publisher
PubMed ID 30717462
DOI 10.3390/cancers11020177
Web of Science KeyUT 000460747200051
Related Url isVersionOf https://doi.org/10.3390/cancers11020177
FullText URL JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg
Author Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Tanaka, Noriyuki| Kato, Hironari| Horiguchi, Shigeru| Yoshida, Ryuichi| Umeda, Yuzo| Fushimi, Soichiro| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki|
Keywords Immunohistochemistry PD-L1 Pancreatic cancer
Note This fulltext will be available in Apr 2020|
Published Date 2019-04-29
Publication Title Journal of Gastroenterology
Volume volume54
Issue issue11
Start Page 1019
End Page 1028
ISSN 09441174
NCID AA10988015
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31032528
DOI 10.1007/s00535-019-01586-6
Web of Science KeyUT 000492169400008
Related Url isVersionOf https://doi.org/10.1007/s00535-019-01586-6
FullText URL OncoImmunol_8_12_1671760.pdf
Author Sakamoto, Shuichi| Kagawa, Shunsuke| Kuwada, Kazuya| Ito, Atene| Kajioka, Hiroki| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kagawa, Tetsuya| Yoshida, Ryuichi| Kikuchi, Satoru| Kuroda, Shinji| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
Published Date 2019-10-22
Publication Title OncoImmunology
Volume volume8
Issue issue12
Publisher TAYLOR & FRANCIS
Start Page e1671760
ISSN 2162402X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Author(s).
File Version publisher
DOI 10.1080/2162402X.2019.1671760
Web of Science KeyUT 000494085400001
Related Url isVersionOf https://doi.org/10.1080/2162402X.2019.1671760
FullText URL AnnGastroenterolSurg_3_4_396.pdf
Author Fujiwara, Toshiyoshi|
Keywords adenovirus clinical trial esophageal cancer radiotherapy telomerase
Published Date 2019-07-05
Publication Title Annals of gastroenterological surgery
Volume volume3
Issue issue4
Publisher John Wiley & Sons
Start Page 396
End Page 404
ISSN 24750328
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors
File Version publisher
PubMed ID 31346579
DOI 10.1002/ags3.12270
Web of Science KeyUT 000475745100009
Related Url isVersionOf https://doi.org/10.1002/ags3.12270
FullText URL Esophagus_16_3_300.pdf Fig.pdf
Author Yokoi, Aya| Ekuni, Daisuke| Yamanaka, Reiko| Hata, Hironobu| Shirakawa, Yasuhiro| Morita, Manabu|
Keywords Deglutition Deglutition disorders Esophageal neoplasms Esophagectomy Intensive care units
Published Date 2019-04-02
Publication Title Esophagus
Volume volume16
Issue issue3
Publisher Springer Singapore
Start Page 300
End Page 308
ISSN 16129059
NCID AA11885266
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30941604
DOI 10.1007/s10388-019-00668-x
Related Url isVersionOf https://doi.org/10.1007/s10388-019-00668-x
JaLCDOI 10.18926/AMO/57377
FullText URL 73_5_457.pdf
Author Iwamuro, Masaya| Takahara, Masahiro| Yamazaki, Tatsuhiro| Tanaka, Takehiro| Kondo, Yoshitaka| Hiraoka, Sakiko| Okada, Hiroyuki|
Abstract A 60-year-old Caucasian male was diagnosed with lung adenocarcinoma and multiple metastases to the bone, spleen, and brain. He underwent radiotherapy for the brain and lumbar spine metastases, plus chemotherapy (cisplatin and pemetrexed). The chemotherapy was discontinued due to vomiting and hyponatremia, and nivolumab was then administered. Eight months later, 18F-fluorodeoxyglucose positron emission tomography showed tracer uptake in the colon. Colonoscopy revealed a reddish multinodular polyp in the sigmoid colon. The polyp showed irregular microvessels. No colonic mucosal surface structures were observed. Colonic metastasis of the lung carcinoma was highly suspected; the polyp was therefore surgically removed. The histological analysis revealed granulation tissue and suppurative inflammation without neoplastic changes. We diagnosed the lesion as a granulation polyp. Despite the difficulty in diagnosing these lesions due to their rarity and similarity to metastatic colon tumors, we suggest that recognizing the endoscopic features of the polyp surface may allow a preoperative diagnosis.
Keywords colonoscopy colonic neoplasms granulation polyp
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-10
Volume volume73
Issue issue5
Publisher Okayama University Medical School
Start Page 457
End Page 461
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31649373
Web of Science KeyUT 000491886600012
FullText URL Gastroenterology156_6_1753.pdf fig.pdf
Author Tomoda, Takeshi| Kato, Hironari| Ueki, Toru| Akimoto, Yutaka| Hata, Hidenori| Fujii, Masakuni| Harada, Ryo| Ogawa, Tsuneyoshi| Wato, Masaki| Takatani, Masahiro| Matsubara, Minoru| Kawai, Yoshinari| Okada, Hiroyuki|
Keywords Drug Inflammation Pancreas Smooth-Muscle Relaxant
Published Date 2019-05-31
Publication Title Gastroenterology
Volume volume156
Issue issue6
Publisher W B SAUNDERS CO-ELSEVIER
Start Page 1753
End Page 1760
ISSN 00165085
NCID AA0065394X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30772342
DOI 10.1053/j.gastro.2019.01.267
Web of Science KeyUT 10.1053/j.gastro.2019.01.267
Related Url isVersionOf https://doi.org/10.1053/j.gastro.2019.01.267
FullText URL CGH17_6_56.pdf fig.pdf
Author Tomoda, Takeshi| Kato, Hironari| Okada, Hiroyuki|
Published Date 2019-05-31
Publication Title Clinical Gastroenterology and Hepatology
Volume volume17
Issue issue6
Publisher Elsevier Science
Start Page e56
End Page e57
ISSN 15423565
NCID AA11845942
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the AGA Institute
File Version author
PubMed ID 29857148
DOI 10.1016/j.cgh.2018.05.032
Web of Science KeyUT 000464657100006
Related Url isVersionOf https://doi.org/10.1016/j.cgh.2018.05.032
FullText URL DLD51_1_168.pdf
Author Iwamuro, Masaya| Urata, Haruo| Tanaka, Takehiro| Okada, Hiroyuki|
Published Date 2019-01-31
Publication Title Digestive and Liver Disease
Volume volume51
Issue issue1
Publisher Elsevier
Start Page 168
ISSN 15908658
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
File Version author
PubMed ID 30145054
DOI 10.1016/j.dld.2018.07.031
Web of Science KeyUT 000454119300026
Related Url isVersionOf https://doi.org/10.1016/j.dld.2018.07.031
Title Alternative The 2017 Incentive Award of the Okayama Medical Association in Cancer Research (2017 Hayashibara Prize and Yamada Prize)
FullText URL 131_5.pdf
Author Sakae, Hiroyuki|
Publication Title Journal of Okayama Medical Association
Published Date 2019-04-01
Volume volume131
Issue issue1
Start Page 5
End Page 7
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.131.5
language Japanese
Copyright Holders Copyright (c) 2019 岡山医学会
File Version publisher
DOI 10.4044/joma.131.5
NAID 130007642651
JaLCDOI 10.18926/AMO/56940
FullText URL 73_4_367.pdf
Author Mifune-Morioka, Tomoyo| A. Uchida, Haruhito| Fukushima, Kazuhiko| Watanabe, Mayu| Ouchi, Chihiro| Mise, Koki| Kawakita, Chieko| Kano, Yuzuki| Onishi, Akifumi| Toma, Kishio| Eguchi, Jun| Wada, Nozomu| Ikeda, Fusao| Sasaki, Erika| Suganami, Yu| Kishida, Masayuki| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun|
Abstract Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.
Keywords autoimmune polyglandular syndrome type 3 systemic lupus erythematosus autoimmune hepatitis slowly progressive insulin-dependent diabetes mellitus chronic thyroiditis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 367
End Page 372
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439961
JaLCDOI 10.18926/AMO/56939
FullText URL 73_4_361.pdf
Author Watanabe, Ayako| Kadowaki, Yoshihiko| Hattori, Kenji| Ohmori, Mika| Tsukayama, Hiroyuki| Kubota, Nobuhito| Okumoto, Tatsuo| Ishido, Nobuhiro| Okino, Takeshi|
Abstract A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely similar to phlebosclerotic colitis in clinical findings; surgical resection was required for correct diagnosis.
Keywords phlebosclerotic colitis colorectal cancer signet ring cell carcinoma young colorectal cancer
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 361
End Page 365
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439960
JaLCDOI 10.18926/AMO/56935
FullText URL 73_4_333.pdf
Author Kuwaki, Kenji| Nouso, Kazuhiro| Miyashita, Manabi| Makino, Yasuhiro| Hagihara, Hiroaki| Moriya, Akio| Adachi, Takuya| Wada, Nozomu| Yasunaka, Yuki| Yasunaka, Tetsuya| Takeuchi, Yasuto| Onishi, Hideki| Nakamura, Shinichiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Okada, Hiroyuki|
Abstract Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) after TACE was significantly less in the steroid group (56/21/0) compared to the control group (35/29/3, p=0.005, Cochran-Armitage test for trend). The suppressive effect of steroids against fever was prominent in females (p=0.001). Vomiting (G0/G1/ G2-) was also less frequent in the steroid group (70/5/2) versus the control group (53/10/3), but not significantly (p=0.106). The algetic degree and the grade of hematological adverse events, including hyperglycemia, did not differ between the groups. We conclude that the administration of steroids was useful for the prevention of adverse events after TACE in patients with HCC.
Keywords antipyretic hepatocellular carcinoma therapeutic chemoembolization steroid
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 333
End Page 339
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439956
JaLCDOI 10.18926/AMO/56862
FullText URL 73_3_205.pdf
Author Mukai, Yuko| Sakurai, Toru| Watanabe, Toshiyuki| Sako, Tomoko| Sugimoto, Morito| Kimata, Yoshihiro| Mori, Yoshiko| Nagasaka, Takeshi| Namba, Yuzaburo|
Abstract Intestinal vaginoplasty has several advantageous features, such as scarless surgery, low incidence of contraction of the reconstructed vagina, maintenance of vaginal depth, spontaneous mucus production, and a low rate of complications. Therefore, this technique is becoming popular in many countries. Following the global trend, the demand for intestinal vaginoplasty for transsexuals is also increasing in Japan. However, there are few reports on intestinal vaginoplasty in Japan. In this study, we examined the safety and effectiveness of rectosigmoid colon vaginoplasty in the Japanese population. We retrospectively surveyed 18 male-to-female transsexuals who underwent laparoscopic rectosigmoid colon vaginoplasty at the Okayama University Hospital Gender Center between October 2012 and December 2017. One patient had developed an anastomotic leak and 2 patients experienced vaginal prolapse, which needed revision surgery. Both adverse outcomes were comparable with those from previous studies. The anastomotic leak was managed adequately with conservative treatment. To avoid vaginal prolapse, it is important to decide the length of the rectosigmoid segment so that a pull on it does not cause it to become lax, while excessive stress on the feeder vessels is avoided. Based on our study, we concluded that rectosigmoid vaginoplasty was a reliable technique in the Japanese population.
Keywords vaginoplasty male-to-female transsexuals rectosigmoid colon
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-06
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 205
End Page 211
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235967
FullText URL K0005903_abstract_review.pdf K0005903_summary.pdf K0005903_fulltext.pdf K0005903_Figure.pdf
Author Adachi, Takuya|
Published Date 2019-03-25
Content Type Thesis or Dissertation
Grant Number 甲第5903号
Granted Date 2019-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
JaLCDOI 10.18926/AMO/56646
FullText URL 73_2_109.pdf
Author Abe, Makoto| Iwamuro, Masaya| Kawahara, Yoshiro| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Tsumura, Munechika| Makino, Takuma| Noda, Yohei| Marunaka, Hidenori| Nishizaki, Kazunori| Okada, Hiroyuki|
Abstract The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. “Resect and watch” is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.
Keywords endoscopic submucosal dissection superficial cancer pharynx endoscopic resection
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-04
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 109
End Page 115
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015745
Title Alternative Video capsule endoscopy usage: Intra-hospital consultations before and after the expansion of indications
FullText URL 130_155.pdf
Author Kawano, Seiji| Iwamuro, Masaya| Inokuchi, Toshihiro| Sugihara, Yuusaku| Harada, Keita| Hiraoka, Sakiko| Okada, Hiroyuki|
Abstract Approximately 10 years have passed since video capsule endoscopy (VCE)was introduced in routine clinical practice in Japan. We started using VCE in January 2009. Here we investigated the contribution of VCE and its level of recognition at our 855-bed hospital. We compared the clinical characteristics of intra-hospital consultation cases with non-consultation cases, and the details of the cases from each of our hospital’s departments. The number of intra-hospital consultations was notably increased by our expansion of the indications for non-obscure gastrointestinal bleeding (OGIB)cases. However, most of our hospital’s departments are sub-departments of internal medicine, in which almost no change in indications has been made. We found that the percentage of OGIB cases was higher among the intra-hospital consultations than non-consultations, and that the OGIB percentages differed markedly among the departments. Especially for OGIB cases, all hospital departments should be better informed regarding the indications for and efficacy of VCE.
Keywords カプセル内視鏡(video capsule endoscopy) 適応拡大(expansion of indication) 院内紹介(intra-hospital consultation)
Publication Title Journal of Okayama Medical Association
Published Date 2018-12-03
Volume volume130
Issue issue3
Start Page 155
End Page 159
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.130.147
language Japanese
Copyright Holders Copyright (c) 2018 岡山医学会
File Version publisher
DOI 10.4044/joma.130.147
NAID 130007542857
JaLCDOI 10.18926/AMO/56463
FullText URL 73_1_81.pdf
Author Sugihara, Yuusaku| Harada, Keita| Oka, Shohei| Yasutomi, Eriko| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Takahara, Masahiro| Hiraoka, Sakiko| Otsuka, Fumio| Okada, Hiroyuki|
Abstract Endoscopic submucosal dissection (ESD) is reportedly one of the standard treatment strategies for large superficial colorectal neoplasms in Japan because of its high en bloc resection rate. A few technical issues regarding ESD should be considered, one of which is the selection of the Endo-cut I mode versus the Swift-coagulation mode as the electrosurgical unit mode setting during submucosal dissection. We seek to determine which of these two modes is more suitable for submucosal dissections of colorectal tumors with regard to procedure time and safety.
Keywords endoscopic submucosal dissection electrosurgical mode colorectal tumor
Amo Type Clinical Study Protocol
Publication Title Acta Medica Okayama
Published Date 2019-02
Volume volume73
Issue issue1
Publisher Okayama University Medical School
Start Page 81
End Page 84
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30820059
JaLCDOI 10.18926/AMO/56462
FullText URL 73_1_77.pdf
Author Morita, Mio| Matsumoto, Hiroshi| Shirakawa, Yasuhiro| Noma, Kazuhiro| Tanabe, Shunsuke| Kimata, Yoshihiro|
Abstract Anterior cervical plate fixation is a common surgical treatment for cervical spine trauma, disc herniation, or cervical spondylosis. Esophageal perforation following anterior cervical plate fixation is a rare but serious complication. Management of esophageal perforation is controversial; however, we suggest treating most cases surgically because this condition is slow to heal and often fatal. We managed 2 cases of esophageal perforation following anterior cervical plate fixation by flap reconstruction with the pectoralis major muscle in one case and a jejunal free flap in the other. Here, we report our experience and review the surgical indications.
Keywords anterior cervical plate fixation esophageal perforation reconstruction pectoralis major flap jejunal free flap
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-02
Volume volume73
Issue issue1
Publisher Okayama University Medical School
Start Page 77
End Page 80
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30820058
JaLCDOI 10.18926/AMO/56457
FullText URL 73_1_43.pdf
Author Ikeda, Ailee| Takaki, Akinobu| Yasunaka, Tetsuya| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Ikeda, Fusao| Shiraha, Hidenori| Yoshida, Kazuhiro| Kuise, Takashi| Nobuoka, Daisuke| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Fujiwara, Toshiyoshi| Okada, Hiroyuki|
Abstract Post-orthotopic liver transplantation (OLT) hepatitis B recurrence is well-controlled with a nucleos(t)ide analogue and hepatitis B immunoglobulin (HBIG) combination, but the high cost and the potential risk of unknown infection associated with HBIG remain unresolved issues. Low-cost recombinant hepatitis B virus (HBV) vaccine administration is a potential solution to these problems. We retrospectively analyzed the rate and predictive factors of HBV vaccine success in 49 post-OLT patients: liver cirrhosis-type B (LC-B), n=28 patients; acute liver failure-type B (ALF-B), n=8; and non-HBV-related end-stage liver disease (non-B ESLD) who received a liver from anti-hepatitis B core antibody-positive donors, n=13. A positive anti-hepatitis B surface antibody response was achieved in 29% (8/28) of the LC-B group, 88% (7/8) of the ALF-B group, and 44% (4/9) of the adult non-B ESLD group. All four non-B ESLD infants showed vaccine success. The predictive factors for a good response in LC-B were young age, marital donor, and high donor age. ALF-B and non-B ESLD infants are thus good vaccination candidates. LC-B patients with marital donors are also good candidates, perhaps because the donated liver maintains an efficient immune memory to HBV, as the donors had already been infected in adulthood and showed adequate anti-HBV immune responses.
Keywords acute liver failure hepatitis B hepatitis B vaccine liver cirrhosis liver transplantation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-02
Volume volume73
Issue issue1
Publisher Okayama University Medical School
Start Page 41
End Page 50
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 30820053