検索結果 - 岡山大学学術成果リポジトリ

Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab

フルテキストURL	fulltext.pdf
著者	Iwamuro, Masaya\| Murakami, Toshi\| Tanaka, Takehiro\| Oka, Shohei\| Kawano, Seiji\| Kawahara, Yoshiro\| Okada, Hiroyuki\|
発行日	2020-06-04
出版物タイトル	Case Reports in Gastrointestinal Medicine
巻	2020巻
出版者	Hindawi
開始ページ	6381670
ISSN	2090-6528
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 Masaya Iwamuro et al.
論文のバージョン	publisher
PubMed ID	32566328
DOI	10.1155/2020/6381670
Web of Science KeyUT	000542326600001
関連URL	isVersionOf https://doi.org/10.1155/2020/6381670

Diagnostic Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Gastric Mesenchymal Tumors

フルテキストURL	fulltext.pdf
著者	Iwamuro, Masaya\| Miyahara, Koji\| Sakaguchi, Chihiro\| Takenaka, Ryuta\| Kobayashi, Sayo\| Mouri, Hirokazu\| Tanaka, Shigetomi\| Toyokawa, Tatsuya\| Tanaka, Shouichi\| Nishimura, Mamoru\| Yamauchi, Kenji\| Tanaka, Takehiro\| Okada, Hiroyuki\|
キーワード	18F-fluorodeoxyglucose-positron emission tomography mesenchymal tumor gastric neoplasms gastrointestinal stromal tumor schwannoma
発行日	2020-05-01
出版物タイトル	Journal of Clinical Medicine
巻	9巻
号	5号
出版者	MDPI
開始ページ	1301
ISSN	2077-0383
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32370028
DOI	10.3390/jcm9051301
Web of Science KeyUT	000540223800058
関連URL	isVersionOf https://doi.org/10.3390/jcm9051301

Effect of Vonoprazan on Delayed Bleeding after Endoscopic Submucosal Dissection for Gastric Neoplasia among Antithrombotic Drug Users: A Single-Center, Single-Arm Prospective Observational Case Control Study

JaLCDOI	10.18926/AMO/59958
フルテキストURL	74_3_245.pdf
著者	Yamamoto, Shumpei\| Takayama, Hiroshi\| Shimodate, Yuichi\| Takezawa, Rio\| Nishimura, Naoyuki\| Doi, Akira\| Mouri, Hirokazu\| Matsueda, Kazuhiro\| Mizuno, Motowo\| Okada, Hiroyuki\|
抄録	Antithrombotic therapy is a major risk factor for delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasia. A potassium-competitive acid blocker, vonoprazan, is expected to prevent delayed bleeding better than conventional proton pomp inhibitors (PPIs), but the evidence is controversial. We sought to clarify the efficacy of vonoprazan for prevention of delayed bleeding after gastric ESD in patients under antithrombotic therapy. We prospectively registered 50 patients who underwent gastric ESD while receiving antithrombotic therapy and vonoprazan in our institution between October 2017 and September 2018. The incidence of delayed bleeding was compared with that in a historical control group of 116 patients treated with conventional PPI. We also evaluated risk factors associated with delayed bleeding. Delayed bleeding was observed in 8 of 50 patients (16.0%), which was not dissimilar from the incidence in the historical control group (12.1%) (p=0.49). In the univariate analysis, age (> 70 years) (p=0.034), multiple antithrombotic drug use (p<0.01), procedure time (> 200 min) (p=0.038) and tumor size (> 40 mm) (p<0.01) were associated with delayed bleeding after gastric ESD, but vonoprazan was not (p=0.49). Vonoprazan may not be more effective than conventional PPIs in preventing delayed bleeding after gastric ESD in patients receiving antithrombotic therapy.
キーワード	vonoprazan endoscopic submucosal dissection antithrombotic drug gastric cancer
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	245
終了ページ	250
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577023
Web of Science KeyUT	000543363400008
NAID	120006862799

Serum REIC/Dickkopf-3 Protein Level Predicts Disease-Free Survival in Patients with Hepatocellular Carcinoma

JaLCDOI	10.18926/AMO/59957
フルテキストURL	74_3_237.pdf
著者	Oyama, Atsushi\| Uchida, Daisuke\| Shiraha, Hidenori\| Sawahara, Hiroaki\| Kato, Ryo\| Iwamuro, Masaya\| Horiguchi, Shigeru\| Okada, Hiroyuki\|
抄録	The physiological role of the reduced expression of immortalized cells (REIC)/Dickkopf-3 (Dkk-3) protein in patients with hepatocellular carcinoma (HCC) remains unclear. In this study, we evaluated the effect of the REIC/Dkk-3 protein on HCC cell proliferation and assessed the relationship between the serum REIC/Dkk-3 protein level and the prognosis in patients with HCC. We evaluated the REIC/Dkk-3 protein-induced anticancer effects on Huh7 and Hep3B cells (HCC cell lines) in the presence of peripheral blood mononuclear cells (PBMCs), and found that combination treatment with REIC/Dkk-3 protein and PBMCs reduced the proliferation of HCC cells (Hep3B: 82.0%±16.3%; Huh7: 72.6%±9.1%). We also studied 194 HCC patients who underwent primary liver resection or primary radiofrequency ablation from 2008 to 2017. Serum REIC/Dkk-3 protein levels were measured by an enzyme-linked immunosorbent assay and compared to the prognostic data. The 3-year disease-free survival of the REIC/Dkk-3 high group was significantly higher than that in the REIC/Dkk-3 low group. In conclusion, this is the first study investigating the relationship between HCC patient survival and serum REIC/Dkk-3 protein levels in a large population. Based on the results, the serum REIC/Dkk-3 protein level should be considered a new prognostic marker for patients with HCC.
キーワード	enzyme-linked immunosorbent assay liver resection primary radiofrequency ablation Huh7 Hep3B
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	237
終了ページ	243
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577022
Web of Science KeyUT	000543363400007
NAID	120006862798

Heterotypic 3D pancreatic cancer model with tunable proportion of fibrotic elements

フルテキストURL	Biomaterials_251_fulltext.pdf Biomaterials_251_supplementarydata.pdf
著者	Tanaka, Hiroyoshi Y.\| Kurihara, Tsuyoshi\| Nakazawa, Takuya\| Matsusaki, Michiya\| Masamune, Atsushi\| Kano, Mitsunobu R.\|
キーワード	3D culture Cancer-associated fibroblast Pancreatic stellate cell Tumor stroma Pancreatic cancer Myofibroblast
備考	©2021 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.biomaterials.2020.120077] . \|
発行日	2020-04-30
出版物タイトル	Biomaterials
巻	251巻
出版者	Elsevier
開始ページ	120077
ISSN	0142-9612
NCID	AA00110092
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	32388166
DOI	10.1016/j.biomaterials.2020.120077
Web of Science KeyUT	000534057500006
関連URL	isVersionOf https://doi.org/10.1016/j.biomaterials.2020.120077

Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness

フルテキストURL	Biomaterials_192_fulltext.pdf Biomaterials_192_supplementarydata.pdf
著者	Tanaka, Hiroyoshi Y.\| Kitahara, Kentaro\| Sasaki, Naoki\| Nakao, Natsumi\| Sato, Kae\| Narita, Hirokazu\| Shimoda, Hiroshi\| Matsusaki, Michiya\| Nishihara, Hiroshi\| Atsushi Masamune\| Kano, Mitsunobu R.\|
キーワード	Fibrosis Extracellular matrix remodeling 3D culture Pancreatic stellate cell SPARC
発行日	2018-11-17
出版物タイトル	Biomaterials
巻	192巻
出版者	Elsevier
開始ページ	355
終了ページ	367
ISSN	0142-9612
NCID	AA00110092
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	30476717
DOI	10.1016/j.biomaterials.2018.11.023
Web of Science KeyUT	000456902000029
関連URL	isVersionOf https://doi.org/10.1016/j.biomaterials.2018.11.023

Bone and Soft-Tissue Sarcoma: A New Target for Telomerase-Specific Oncolytic Virotherapy

フルテキストURL	fulltext.pdf
著者	Tazawa, Hiroshi\| Hasei, Joe\| Yano, Shuya\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
キーワード	oncolytic adenovirus hTERT autophagy GFP p53
発行日	2020-02-18
出版物タイトル	Cancers
巻	12巻
号	2号
出版者	MDPI
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32085583
DOI	10.3390/cancers12020478
Web of Science KeyUT	000522477300224
関連URL	isVersionOf https://doi.org/10.3390/cancers12020478

Intestinal Diffuse Large B-Cell Lymphoma in a Patient with Systemic Lupus Erythematosus

フルテキストURL	fulltext.pdf
著者	Iwamuro, Masaya\| Takahashi, Takahide\| Ota, Yoko\| Tanaka, Takehiro\| Asada, Noboru\| Yano, Shuya\| Uka, Mayu\| Nakamura, Rei\| Baba, Yuki\| Kawano, Seiji\| Kawahara, Yoshiro\| Okada, Hiroyuki\|
発行日	2020-04-09
出版物タイトル	Case Reports in Gastrointestinal Medicine
巻	2020巻
出版者	Hindawi
開始ページ	7947540
ISSN	2090-6528
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 Masaya Iwamuro et al.
論文のバージョン	publisher
PubMed ID	32328319
DOI	10.1155/2020/7947540
Web of Science KeyUT	000528921300002
関連URL	isVersionOf https://doi.org/10.1155/2020/7947540

Pediatric Living Donor Liver Transplantation for Congenital Absence of the Portal Vein With Pulmonary Hypertension: A Case Report

フルテキストURL	fulltext.pdf
著者	Matsumoto, Naohisa\| Matsusaki, Takashi\| Hiroi, Kazumasa\| Kaku, Ryuji\| Yoshida, Ryuichi\| Umeda, Yuzo\| Yagi, Takahito\| Morimatsu, Hiroshi\|
備考	11th Congress of the Andalusian-Society-of-Organ-and-Tissue-Transplantation (SATOT)\|
発行日	2020-03-31
出版物タイトル	Transplantation Proceedings
巻	52巻
号	2号
出版者	Elsevier
開始ページ	630
終了ページ	633
ISSN	00411345
NCID	AA00868957
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors. Published by Elsevier Inc.
論文のバージョン	publisher
PubMed ID	32029317
DOI	10.1016/j.transproceed.2019.11.032
Web of Science KeyUT	000518473000059
関連URL	isVersionOf https://doi.org/10.1016/j.transproceed.2019.11.032

Correction to: Outcomes of endoscopic treatment for malignant biliary obstruction in patients with surgically altered anatomy: analysis of risk factors for clinical failure

フルテキストURL	text_correction.pdf table3_correction.pdf
著者	Tomoda, Takeshi \| Kato, Hironari\| Miyamoto, Kazuya\| Matsumi, Akihiro\| Ueta, Eijiro\| Fujii, Yuuki\| Saragai, Yousuke\| Yamazaki, Tatsuhiro\| Uchida, Daisuke\| Matsumoto, Kazuyuki\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Okada, Hiroyuki\|
備考	Correction to: Surgical Endoscopy https://doi.org/10.1007/s00464-020-07385-y\|
発行日	2020-02-06
出版物タイトル	Surgical Endoscopy
巻	35巻
号	1号
出版者	Springer
開始ページ	239
終了ページ	240
ISSN	09302794
NCID	AA10750363
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	32030547
DOI	10.1007/s00464-020-07399-6
Web of Science KeyUT	000515963500002
関連URL	isVersionOf https://doi.org/10.1007/s00464-020-07399-6

Outcomes of endoscopic treatment for malignant biliary obstruction in patients with surgically altered anatomy: analysis of risk factors for clinical failure

フルテキストURL	fulltext.pdf table.pdf
著者	Tomoda, Takeshi\| Kato, Hironari\| Miyamoto, Kazuya\| Matsumi, Akihiro\| Ueta, Eijiro\| Fujii, Yuuki\| Saragai, Yousuke\| Yamazaki, Tatsuhiro\| chida, Daisuke\| atsumoto, Kazuyuki\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Okada, Hiroyuki\|
キーワード	Malignant biliary obstruction Double-balloon enteroscope Endoscopic retrograde cholangiopancreatography Surgically altered anatomy
備考	This fulltext is aailable in Jan. 2021.\|
発行日	2020-01-16
出版物タイトル	Surgical Endoscopy
ISSN	09302794
NCID	AA10750363
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31950273
DOI	10.1007/s00464-020-07385-y
Web of Science KeyUT	000507705600001
関連URL	isVersionOf https://doi.org/10.1007/s00464-020-07385-y

DV200 Index for Assessing RNA Integrity in Next-Generation Sequencing

フルテキストURL	fulltext.pdf
著者	Matsubara, Takehiro\| Soh, Junichi\| Morita, Mizuki\| Uwabo, Takahiro\| Tomida, Shuta\| Fujiwara, Toshiyoshi\| Kanazawa, Susumu\| Toyooka, Shinichi\| Hirasawa, Akira\|
発行日	2020-02-27
出版物タイトル	BioMed Research International
巻	2020巻
出版者	Hindawi
開始ページ	9349132
ISSN	2314-6133
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 Takehiro Matsubara et al.
論文のバージョン	publisher
PubMed ID	32185225
DOI	10.1155/2020/9349132
Web of Science KeyUT	000522222100002
関連URL	isVersionOf https://doi.org/10.1155/2020/9349132

ディスペプシア症状を訴えるヘリコバクター・ピロリ感染胃炎に対する除菌治療と，プロトンポンプ阻害剤，消化管運動機能改善剤の組み合わせ治療による症状改善効果の検討

タイトル（別表記）	Efficacy of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) or PPI plus a prokinetic in H. pylori-positive patients with dyspepsia
フルテキストURL	131_139.pdf
著者	三浦公\| 岩室雅也\| 豊川達也\| 竹中龍太\| 井上雅文\| 伊藤守\| 岡田裕之\|
抄録	To investigate whether treatment comprised of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) alone and a dual treatment with a PPI plus a prokinetic agent helps relieve symptoms, we treated 26 patients with H. pylori infection and dyspepsia with the sequential treatment and assessed their symptoms. Scores for gastroesophageal reflux disease (GERD) and dyspepsia in a modified F-scale were significantly improved after the eradication of H. pylori, and symptoms were completely relieved in 13 patients. The remaining 13 patients received 4-week treatment with the PPI rabeprazole, and their GERD scores significantly improved after the treatment. The symptoms of five patients completely disappeared ; the other eight patients required dual treatment with a PPI plus the prokinetic acotiamide. Early satiety tended to be relieved after the dual treatment, but the improvement was not significant. Thus, in patients with dyspepsia and an H. pylori infection, the H. pylori should be eradicated first. The administration of a PPI is useful in patients with GERD symptoms, and a PPI+ acotiamide may be beneficial for residual symptoms of early satiety.
キーワード	機能性ディスペプシア (functional dyspepsia) ヘリコバクター・ピロリ (Helicobacter pylori) プロトンポンプ阻害剤 (proton pomp inhibitor) 消化管運動機能改善剤 (acotiamide)
出版物タイトル	岡山医学会雑誌
発行日	2019-12-02
巻	131巻
号	3号
開始ページ	139
終了ページ	143
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.131.139
言語	日本語
著作権者	Copyright (c) 2019 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.131.139
NAID	130007782646

平成30年度岡山医学会賞がん研究奨励賞（林原賞・山田賞）

タイトル（別表記）	The 2018 Incentive Award of the Okayama Medical Association in Cancer Research (2018 Hayashibara Prize and Yamada Prize)
フルテキストURL	131_127.pdf
著者	加藤卓也\|
出版物タイトル	岡山医学会雑誌
発行日	2019-12-02
巻	131巻
号	3号
開始ページ	127
終了ページ	130
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.131.127
言語	日本語
著作権者	Copyright (c) 2019 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.131.127
NAID	130007782637

Single-session esophagogastroduodenoscopy and endoscopic ultrasound using a forward-viewing radial scan ultrasonic endoscope

フルテキストURL	fulltext.pdf
著者	Uchida, Daisuke\| Kato, Hironari\| Matsumoto, Kazuyuki\| Ishihara, Yuki\| Matsumi, Akihiro\| Saragai, Yosuke\| Takada, Saimon\| Yabe, Shuntaro\| Muro, Shinichiro\| Tomoda, Takeshi\| Horiguchi, Shigeru\| Okada, Hiroyuki\|
キーワード	Endoscopic ultrasound Diagnostic screening program Pancreatic diseases Biliary tract diseases
発行日	2019-12-18
出版物タイトル	BMC Gastroenterology
巻	19巻
号	1号
出版者	BMC
開始ページ	220
ISSN	1471-230X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2019
論文のバージョン	publisher
PubMed ID	31852458
DOI	10.1186/s12876-019-1141-7
Web of Science KeyUT	000510482800002
関連URL	isVersionOf https://doi.org/10.1186/s12876-019-1141-7

Prognostic significance of the controlling nutritional status (CONUT) score in patients undergoing hepatectomy for hepatocellular carcinoma: a systematic review and meta-analysis

フルテキストURL	fulltext.pdf
著者	Takagi, Kosei\| Domagala, Piotr\| Polak, Wojciech G.\| Buettner, Stefan\| Ijzermans, Jan N. M.\|
キーワード	Controlling nutritional status (CONUT) score Hepatocellular carcinoma Outcome Meta-analysis
発行日	2019-12-09
出版物タイトル	BMC Gastroenterology
巻	19巻
号	1号
出版者	BMC
開始ページ	211
ISSN	1471-230X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2019
論文のバージョン	publisher
PubMed ID	31818259
DOI	10.1186/s12876-019-1126-6
Web of Science KeyUT	000510482200001
関連URL	isVersionOf https://doi.org/10.1186/s12876-019-1126-6

Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells

フルテキストURL	fulltext.pdf
著者	Yoshioka, Takahiro\| Shien, Kazuhiko\| Takeda, Tatsuaki\| Takahashi, Yuta\| Kurihara, Eisuke\| Ogoshi, Yusuke\| Namba, Kei\| Torigoe, Hidejiro\| Sato, Hiroki\| Tomida, Shuta\| Yamamoto, Hiromasa\| Soh, Junichi\| Fujiwara, Toshiyoshi\| Toyooka, Shinichi\|
キーワード	afatinib gastric cancer HER2 MET YES1
発行日	2019-06-04
出版物タイトル	Cancer Science
巻	110巻
号	8号
出版者	Wiley Open Access
開始ページ	2549
終了ページ	2557
ISSN	1347-9032
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Authors.
論文のバージョン	publisher
PubMed ID	31162771
DOI	10.1111/cas.14089
Web of Science KeyUT	000478616800022
関連URL	isVersionOf https://doi.org/10.1111/cas.14089

Switching between Three Types of Mesalazine Formulation and Sulfasalazine in Patients with Active Ulcerative Colitis Who Have Already Received High-Dose Treatment with These Agents

フルテキストURL	fulltext.pdf
著者	Yasutomi, Eriko\| Hiraoka, Sakiko\| Yamamoto, Shumpei\| Oka, Shohei\| Hirai, Mami\| Yamasaki, Yasushi\| Inokuchi, Toshihiro\| Kinugasa, Hideaki\| Takahara, Masahiro\| Harada, Keita\| Kato, Jun\| Okada, Hiroyuki\|
キーワード	ulcerative colitis salicylates mesalazine sulfasalazine
発行日	2019-12-02
出版物タイトル	Journal of Clinical Medicine
巻	8巻
号	12号
出版者	MDPI
ISSN	2077-0383
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 by the authors.
論文のバージョン	publisher
PubMed ID	31810227
DOI	10.3390/jcm8122109
Web of Science KeyUT	000506640400082
関連URL	isVersionOf https://doi.org/10.3390/jcm8122109

Clinical Relevance of Blood Glucose and Gastroesophageal Reflux Symptoms to Depressive Status in Patients with Type 2 Diabetes Mellitus

JaLCDOI	10.18926/AMO/57950
フルテキストURL	74_1_33.pdf
著者	Honda, Hiroyuki\| Hanayama, Yoshihisa\| Obika, Mikako\| Hasegawa, Kou\| Hamahara, Jun\| Kishida, Masayuki\| Hagiya, Hideharu\| Ogawa, Hiroko\| Kataoka, Hitomi\| Otsuka, Fumio\|
抄録	A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients’ gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups’ characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients’ SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients’ PPG levels were correlated with GERD-related symptoms, diabetic patients’ blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful
キーワード	blood glucose type 2 diabetes mellitus gastroesophageal reflux depressive status postprandial plasma glucose
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-02
巻	74巻
号	1号
出版者	Okayama University Medical School
開始ページ	33
終了ページ	40
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32099246
Web of Science KeyUT	000516606200005
NAID	120006795617

A Promising New Anti-Cancer Strategy: Iron Chelators Targeting CSCs

JaLCDOI	10.18926/AMO/57946
フルテキストURL	74_1_1.pdf
著者	Chen, Yuehua\| Ohara, Toshiaki\| Xing, Boyi\| Qi, Jiping\| Noma, Kazuhiro\| Matsukawa, Akihiro\|
抄録	Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings.
キーワード	cancer stem cell stemness iron chelation chemotherapy
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2020-02
巻	74巻
号	1号
出版者	Okayama University Medical School
開始ページ	1
終了ページ	6
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32099242
Web of Science KeyUT	000516606200001
NAID	120006795613