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JaLCDOI 10.18926/AMO/66924
FullText URL 78_2_151.pdf
Author Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Abstract Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
Keywords soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 151
End Page 161
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688833
Web of Science KeyUT 001229151800007
FullText URL fulltext.pdf
Author Kitamura, Wataru| Kuratsune, Masatoshi| Iseki, Akiko| Kuyama, Shoichi|
Published Date 2024-03-27
Publication Title Rheumatology Advances in Practice
Volume volume8
Issue issue2
Publisher Oxford University Press
Start Page rkae045
ISSN 2514-1775
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
PubMed ID 38618140
DOI 10.1093/rap/rkae045
Web of Science KeyUT 001201694800001
Related Url isVersionOf https://doi.org/10.1093/rap/rkae045
JaLCDOI 10.18926/AMO/66915
FullText URL 78_2_123.pdf
Author Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu|
Abstract Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT.
Keywords GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 123
End Page 134
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688830
Web of Science KeyUT 001229151800004
JaLCDOI 10.18926/AMO/66912
FullText URL 78_2_095.pdf
Author Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki|
Abstract The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases.
Keywords neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 95
End Page 106
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688827
Web of Science KeyUT 001229151800001
FullText URL fulltext.pdf
Author Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Nishida, Kenji| Yanai, Hiroyuki| Nakamura, Tomoki| Tanaka, Kazuhiro| Ozaki, Toshifumi|
Keywords alveolar soft part sarcoma surgery chemotherapy targeted therapy immunotherapy
Published Date 2023-08-25
Publication Title Japanese Journal of Clinical Oncology
Volume volume53
Issue issue11
Publisher Oxford University Press (OUP)
Start Page 1009
End Page 1018
ISSN 1465-3621
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37626447
DOI 10.1093/jjco/hyad102
Web of Science KeyUT 001080372000001
Related Url isVersionOf https://doi.org/10.1093/jjco/hyad102
FullText URL fulltext.pdf
Author Masuda, Kanae| Kuwada, Eriko| Suzuki, Maria| Suzuki, Tetsuya| Niikawa, Takeshi| Uchida, Seiichi| Akagi, Takashi|
Keywords Artificial intelligence Backpropagation Convolutional neural network Image diagnosis Physiological disorder
Published Date 2023-05-24
Publication Title Plant And Cell Physiology
Volume volume64
Issue issue11
Publisher Oxford University Press (OUP)
Start Page 1323
End Page 1330
ISSN 0032-0781
NCID AA0077511X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37225398
DOI 10.1093/pcp/pcad050
Web of Science KeyUT 001003754000001
Related Url isVersionOf https://doi.org/10.1093/pcp/pcad050
FullText URL fulltext.pdf
Author Denno, Satoshi| Makabe, Shuhei| Hou, Yafei|
Keywords overloaded MIMO non-linear detector soft-input decoding noise cancellation ordering complexity reduction
Published Date 2024-03
Publication Title IEICE Transactions on Communications
Volume volumeE107-B
Issue issue3
Publisher Institute of Electrical and Electronics Engineers (IEEE)
Start Page 339
End Page 348
ISSN 1745-1345
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Institute of Electronics, Information and Communication Engineers
File Version publisher
DOI 10.23919/transcom.2023ebp3118
Web of Science KeyUT 001196412300003
Related Url isVersionOf https://doi.org/10.23919/transcom.2023ebp3118
JaLCDOI 10.18926/interdisciplinary/66896
Title Alternative Advanced Hospital Training Activities in Fiscal 2023
FullText URL interdisciplinary_4_31.pdf
Author MORITA, Mizuki| MORI, Tomoaki| AIDA, Toshiaki| WATANABE, Toyohiko| FUJII, Daiji| HARADA, Nahoko| HAKAMADA, Rei| YOSHIBA, Yasuyuki|
Publication Title Interdisciplinary Science
Published Date 2024-03-31
Volume volume4
Start Page 31
End Page 39
ISSN 2436-3227
language Japanese
File Version publisher
JaLCDOI 10.18926/interdisciplinary/66892
Title Alternative Interdisciplinary Science Contributing to Sustainable Development of Human Society
FullText URL interdisciplinary_4_1.pdf
Author GOFUKU, Akio|
Abstract With the increase of the complexity of human society because of the globalization and the advancement of each scientific field, innovations by effective collaborations of experts in various fields become necessary to solve problems in human society and to increase the findings of each field. From the backgrounds, the interdisciplinary science b ecomes popular in recent y ears. This article p resents the approach of interdisciplinary science and its importance to the sustainable development of human society. As an example of studies by interdisciplinary science, this article introduces a virtual reality based mirror visual feedback therapy system that the author has been developed in collaboration with medical doctors, professors in engineering field and students of the author’s laboratory in Okayama University.
Keywords Interdisciplinary science Collaboration of medicine and engineering Virtual reality Mirror visual feedback therapy system
Publication Title Interdisciplinary Science
Published Date 2024-03-31
Volume volume4
Start Page 1
End Page 17
ISSN 2436-3227
language Japanese
File Version publisher
FullText URL fulltext.pdf
Author Kanzaki, Yuki| Matoba, Ryo| Ishihara, Kenji| Morita, Tetsuro| Muraoka, Yuki| Kimura, Shuhei| Koto, Takashi| Kawasaki, Ryo| Baba, Takayuki| Okamoto, Fumiki| Inoue, Makoto| Sakamoto, Taiji| Tsujikawa, Akitaka| Morizane, Yuki|
Published Date 2024-02-08
Publication Title PLoS ONE
Volume volume19
Issue issue2
Publisher Public Library of Science
Start Page e0297347
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Kanzaki et al.
File Version publisher
PubMed ID 38329968
DOI 10.1371/journal.pone.0297347
Web of Science KeyUT 001164302700019
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0297347
FullText URL fulltext.pdf
Author Li, Hongjie| Nakajima, Yoshiki| Nango, Eriko| Owada, Shigeki| Yamada, Daichi| Hashimoto, Kana| Luo, Fangjia| Tanaka, Rie| Akita, Fusamichi| Kato, Koji| Kang, Jungmin| Saitoh, Yasunori| Kishi, Shunpei| Yu, Huaxin| Matsubara, Naoki| Fujii, Hajime| Sugahara, Michihiro| Suzuki, Mamoru| Masuda, Tetsuya| Kimura, Tetsunari| Thao, Tran Nguyen| Yonekura, Shinichiro| Yu, Long-Jiang| Tosha, Takehiko| Tono, Kensuke| Joti, Yasumasa| Hatsui, Takaki| Yabashi, Makina| Kubo, Minoru| Iwata, So| Isobe, Hiroshi| Yamaguchi, Kizashi| Suga, Michihiro| Shen, Jian-Ren|
Note The version of record of this article, first published in Nature, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41586-023-06987-5|
Published Date 2024-01-31
Publication Title Nature
Volume volume626
Issue issue7999
Publisher Springer Science and Business Media LLC
Start Page 670
End Page 677
ISSN 0028-0836
NCID AA00752384
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38297122
DOI 10.1038/s41586-023-06987-5
Web of Science KeyUT 001179152900004
Related Url isVersionOf https://doi.org/10.1038/s41586-023-06987-5
FullText URL fulltext.pdf
Author Nakano, Yasuhiro| Sunada, Naruhiko| Tokumasu, Kazuki| Honda, Hiroyuki| Otsuka, Yuki| Sakurada, Yasue| Matsuda, Yui| Hasegawa, Toru| Omura, Daisuke| Ochi, Kanako| Yasuda, Miho| Hagiya, Hideharu| Ueda, Keigo| Otsuka, Fumio|
Keywords Diabetes mellitus Endocrine disorders Long COVID Metabolic disorders Thyroid disease
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-55526-3|
Published Date 2024-03-05
Publication Title Scientific Reports
Volume volume14
Issue issue1
Publisher Nature Portfolio
Start Page 5446
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38443459
DOI 10.1038/s41598-024-55526-3
Web of Science KeyUT 001180457200009
Related Url isVersionOf https://doi.org/10.1038/s41598-024-55526-3
JaLCDOI 10.18926/66833
Title Alternative Trends in the Advancement of Port Cargo Handling at Container Terminals in Japan
FullText URL hss_057_149.pdf
Author MORIYAMA, Hiroki|
Publication Title Journal of Humanities and Social Sciences
Published Date 2024-03-29
Volume volume57
Start Page 149
End Page 167
ISSN 1881-1671
language Japanese
Copyright Holders Copyright (c) 2024 岡山大学大学院社会文化科学研究科
File Version publisher
FullText URL fulltext20240319-01.pdf
Author Makihara, Seiichiro| Otani, Yoshihiro| Uraguchi, Kensuke| Shimizu, Aiko| Murai, Aya| Higaki, Takaya| Akisada, Naoki| Fujimoto, Shohei| Makino, Takuma| Ishida, Joji| Fujii, Kentaro| Yasuhara, Takao| Ota, Tomoyuki| Matsumoto, Hiroshi| Ando, Mizuo|
Keywords anterior skull base malignant tumors anterolateral thigh flap endoscopic endonasal and transcranial surgery ORBEYE skull base reconstruction
Published Date 2024-03-07
Publication Title Head & Neck
Volume volume46
Issue issue5
Publisher Wiley
Start Page 1074
End Page 1082
ISSN 1043-3074
NCID AA10732962
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Authors.
File Version publisher
PubMed ID 38450867
DOI 10.1002/hed.27724
Web of Science KeyUT 001179620500001
Related Url isVersionOf https://doi.org/10.1002/hed.27724
FullText URL fulltext20240311-01.pdf
Author ISOBE, Kazuma| YAMADA, Yutaka| HORIBE, Akihiko| HANAMURA, Katsunori|
Keywords Surface plasmon polariton Circuit resonance Magnetic polariton Lumped-element model Fabry–Pérot interference
Published Date 2024
Publication Title Journal of Thermal Science and Technology
Volume volume19
Issue issue1
Publisher The Japan Society of Mechanical Engineers and The Heat Transfer Society of Japan
Start Page 23-00531
ISSN 1880-5566
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 by The Japan Society of Mechanical Engineers and The Heat Transfer Society of Japan
File Version publisher
DOI 10.1299/jtst.23-00531
Web of Science KeyUT 001167960500002
Related Url isVersionOf https://doi.org/10.1299/jtst.23-00531
FullText URL fulltext.pdf
Author Zahir, Aliya Mhd| Somura, Hiroaki| Moroizumi, Toshitsugu|
Keywords Google Earth Engine agricultural practices irrigation remote sensing Sentinel-1
Published Date 2024
Publication Title Hydrological Research Letters
Volume volume18
Issue issue1
Publisher Japan Society of Hydrology and Water Resources (JSHWR) / Japanese Association of Groundwater Hydrology (JAGH) / Japanese Association of Hydrological Sciences (JAHS) / Japanese Society of Physical Hydrology (JSPH)
Start Page 14
End Page 21
ISSN 1882-3416
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
DOI 10.3178/hrl.18.14
Web of Science KeyUT 001167965700001
Related Url isVersionOf https://doi.org/10.3178/hrl.18.14
JaLCDOI 10.18926/AMO/66672
FullText URL 78_1_063.pdf
Author Murakami, Daizo| Nishimoto, Kohei| Takao, Soshi| Miyamaru, Satoru| Kadowaki, Tomoka| Saito, Haruki| Takeda, Hiroki| Ise, Momoko| Suyama, Koichi| Orita, Yorihisa|
Abstract The tyrosine kinase inhibitor lenvatinib has been confirmed as an effective treatment option for patients with unresectable thyroid carcinoma. We conducted a retrospective analysis of the significance of the effect of continued lenvatinib treatment for the longest duration possible at a reasonable daily dose and with a minimum discontinuation period in 42 patients with unresectable thyroid carcinoma treated with lenvatinib between 2015 and 2020. A Cox proportional hazard model-based analysis revealed that the overall survival of the patients treated with a <8 mg/day mean dose of lenvatinib was significantly better than that of the patients treated with 8-24 mg/day (hazard ratio [HR] 0.38 for 1.14-4.54 mg/day, and HR 0.01 for 4.56-7.97 mg/day) adjusted for various factors (e.g., sex, age, drug interruption period). The cumulative dose of lenvatinib administered tended to be higher in the patients treated with low doses (< 8 mg/day) than in the patients treated with relatively high doses (8-24 mg/day). Considering its adverse events, the continuation of lenvatinib treatment with an adequate daily dose and drug interruption may help prolong the survival of patients with unresectable thyroid carcinoma.
Keywords thyroid carcinoma lenvatinib adverse effect survival
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 63
End Page 70
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419316
Web of Science KeyUT 001203658200007
JaLCDOI 10.18926/AMO/66670
FullText URL 78_1_047.pdf
Author Shimomura, Manabu| Shinozaki, Katsunori| Yano, Takuya| Akabane, Shintaro| Ohdan, Hideki| Hiroshima Surgical study group of Clinical Oncology (HiSCO)|
Abstract Oral fluoropyrimidines (FUs) have certain advantages over intravenous FUs, such as longer intervals between outpatient visits, no requirement for central venous port (CVP) implantation, and lower incidence of neutropenia. We previously reported the efficacy of S-1/oxaliplatin (SOX) with bevacizumab therapy as a first-line treatment for advanced colorectal cancer (CRC) in a prospective phase-II multi-institutional clinical trial (HiSCO-02 study). However, our prognostic data at the time lacked a sufficient observation period. Herein, we analyze the longer-term follow-up data, focusing on the status of eventual CVP implantation via an open-label, non-randomized, multicenter study. This study enrolled 55 patients (mean age, 64 years), of whom 43 died (41 of primary cancer). The median overall survival was 22.7 months (95% CI: 20.1-34.7 months). Post-treatment regimens after failure of first-line treatment were initiated in 43 patients; CPT11-based regimens were selected in most cases, and other oral FU combinations in nine. CVP was implanted in 35 patients prior to first-line treatment; eleven of the remaining 20 patients did not require CVP implantation. In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen.
Keywords metastatic colorectal cancer chemotherapy S-1 prospective phase II study
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 47
End Page 52
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419314
Web of Science KeyUT 001203658200005
FullText URL fulltext20240221-01.pdf
Author Iijima, Yuta| Miki, Ryohei| Fujimura, Masatake| Oyadomari, Seiichi| Uehara, Takashi|
Keywords Methylmercury Neuronal cell death Apoptosis CHOP Knockout mouse
Published Date 2024
Publication Title The Journal of Toxicological Sciences
Volume volume49
Issue issue2
Publisher Japanese Society of Toxicology
Start Page 55
End Page 60
ISSN 0388-1350
NCID AN00002808
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Japanese Society of Toxicology
File Version publisher
PubMed ID 38296529
DOI 10.2131/jts.49.55
Web of Science KeyUT 001157348600004
Related Url isVersionOf https://doi.org/10.2131/jts.49.55
FullText URL fulltext20240219-04.pdf
Author Takahara, Kazuma| Horino, Yuki| Wada, Koki| Sakata, Hiromu| Tomita, Daichi| Sunatsuki, Yukinari| Isobe, Hiroshi| Kojima, Masaaki| Suzuki, Takayoshi|
Published Date 2024
Publication Title CrystEngComm
Volume volume26
Issue issue7
Publisher Royal Society of Chemistry (RSC)
Start Page 1004
End Page 1014
ISSN 1466-8033
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Royal Society of Chemistry 2024
File Version publisher
DOI 10.1039/d3ce01192e
Web of Science KeyUT 001153946300001
Related Url isVersionOf https://doi.org/10.1039/d3ce01192e