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JaLCDOI 10.18926/AMO/68646
FullText URL 79_2_081.pdf
Author Kawada, Tatsushi| Kobayashi, Yasuyuki| Tsugawa, Takuji| Tsuboi, Kazuma| Katayama, Satoshi| Iwata, Takehiro| Bekku, Kensuke| Kobayashi, Tomoko| Edamura, Kohei| Ebara, Shin| Araki, Motoo|
Abstract We retrospectively evaluated the oncologic outcomes of paclitaxel, cisplatin, and gemcitabine (PCG) with those of gemcitabine and cisplatin (GC) as neoadjuvant chemotherapy in muscle-invasive bladder cancer (MIBC) patients. The primary outcome was efficacy: pathological complete response (pCR), ypT0N0; and pathological objective response (pOR), ypT0N0, ≤ ypT1N0, or ypT0N1. Secondary outcomes included overall survival (OS), recurrence-free survival (RFS), predictive factors for pOR, OS, and RFS, and hematologic adverse events (AEs). Among 113 patients treated (PCG, n=28; GC, n=85), similar pOR and pCR rates were achieved by the groups (pOR: PCG, 57.1% vs. GC, 49. 4%; p=0.52; pCR: PCG, 39.3% vs. GC, 29.4%; p=0.36). No significant differences were observed in OS (p=1.0) or RFS (p=0.20). Multivariate logistic regression analysis showed that hydronephrosis (odds ratio [OR] 0.32, 95%CI: 0.11-0.92) and clinical node-positive status (cN+) (OR 0.22, 95%CI: 0.050-0.99) were significantly associated with a decreased probability of pOR. On multivariate Cox regression analyses, pOR achievement was associated with improved OS (hazard ratio [HR] 0.23, 95%CI: 0.10-0.56) and RFS (HR 0.30, 95%CI: 0.13-0.67). There were no significant between-group differences in the incidence of grade ≥ 3 hematologic AEs or dose-reduction required, but the PCG group had a higher incidence of grade 4 neutropenia.
Keywords urothelial carcinoma paclitaxel cisplatin gemcitabine neoadjuvant
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-04
Volume volume79
Issue issue2
Publisher Okayama University Medical School
Start Page 81
End Page 92
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/68645
FullText URL 79_2_075.pdf
Author Higaki, Fumiyo| Morimitsu, Yusuke| Iguchi, Toshihiro| Hwang, Sung Il| Kitayama, Takahiro| Takahashi, Yuka| Uka, Mayu| Akagi, Noriaki| Sugaya, Akiko| Mitsuhashi, Toshiharu| Matsui, Yusuke| Hiraki, Takao|
Abstract Temporal bone computed tomography (CT) is frequently performed for pediatric patients with ear diseases. Advances in CT technology have improved diagnostic imaging quality, but reduction of radiation exposure remains a goal. We evaluated the potential for radiation dose reduction in temporal bone CT examinations using porcine ear ossicles and a photon-counting detector CT system. Three scans of the bilateral temporal bone were performed on each of three pig cadaver heads. In each of seven successive imaging sessions, the radiation dose was reduced by an additional one-seventh of the recommended dose (RD). Two board-certified radiologists independently scored the resulting images on a scale of 1 to 5 points, where 5 represented the image quality at the RD. Images scoring ≥4.5 points were considered acceptable. Noise was assessed in a 2-cm-diameter region near the ear ossicles, and standard deviation was measured for each of the seven decrements from the RD. As the radiation dose decreased, the noise progressively increased, and visual assessment scores progressively decreased. Acceptable image scores were obtained at six-sevenths (4.9), five-sevenths (4.8), four-sevenths (4.7), and three-sevenths (4.6) of the RD. Thus, acceptable porcine temporal bone CT images were obtained with a radiation dose reduction of approximately 50%.
Keywords computed tomography photon-counting detector computed tomography ear ossicle energy-integrating detector computed tomography
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-04
Volume volume79
Issue issue2
Publisher Okayama University Medical School
Start Page 75
End Page 80
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
FullText URL fulltext.pdf
Author Tanaka, Shin| Nakata, Eiji| Ryuko, Tsuyoshi| Itano, Takuto| Tomioka, Yasuaki| Shien, Kazuhiko| Suzawa, Ken| Miyoshi, Kentaroh| Okazaki, Mikio| Sugimoto, Seiichiro| Ozaki, Toshifumi| Toyooka, Shinichi|
Keywords Primary chest wall sarcomas Chest wall resection Chondrosarcoma Robust chest wall reconstruction
Published Date 2025-04-01
Publication Title European Journal of Orthopaedic Surgery & Traumatology
Volume volume35
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 141
ISSN 1432-1068
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40167819
DOI 10.1007/s00590-025-04260-1
Web of Science KeyUT 001459451400002
Related Url isVersionOf https://doi.org/10.1007/s00590-025-04260-1
JaLCDOI 10.18926/interdisciplinary/68625
Title Alternative Practicing the Innovation Loop: 2024 Report on Advanced Hospital Practicums and Future Challenges
FullText URL interdisciplinary_5_39.pdf
Author HARADA, Nahoko| TAKAHASHI, Satoshi| MORI, Tomoaki| HIKASA, Haruka| SHISHIDO, Keisuke| MAGARI, Masaki| WATANABE, Toyohiko| Wang, Jin| MORITA, Mizuki|
Publication Title Interdisciplinary Science
Published Date 2025-03-31
Volume volume5
Start Page 39
End Page 45
ISSN 2436-3227
language Japanese
File Version publisher
FullText URL fulltext.pdf
Author Nishii, Naoko| Kawai, Tomoko| Yasuoka, Hiroki| Abe, Tadashi| Tatsumi, Nanami| Harada, Yuika| Miyaji, Takaaki| Li, Shunai| Tsukano, Moemi| Watanabe, Masami| Ogawa, Daisuke| Wada, Jun| Takei, Kohji| Yamada, Hiroshi|
Keywords VGLUT3 glutamate podocyte glutamatergic transmission
Published Date 2025-03-11
Publication Title International Journal of Molecular Sciences
Volume volume26
Issue issue6
Publisher MDPI
Start Page 2485
ISSN 1661-6596
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by the authors.
File Version publisher
PubMed ID 40141129
DOI 10.3390/ijms26062485
Web of Science KeyUT 001452693900001
Related Url isVersionOf https://doi.org/10.3390/ijms26062485
FullText URL fulltext.pdf
Author Fujii, Yuki| Matsumoto, Kazuyuki| Ochi, Kiyoaki| Himei, Hitomi| Sakakihara, Ichiro| Ueta, Eijiro| Toyokawa, Tatsuya| Harada, Ryo| Ogawa, Taiji| Tomoda, Takeshi| Kato, Hironari| Sato, Ryosuke| Obata, Taisuke| Matsumi, Akihiro| Miyamoto, Kazuya| Uchida, Daisuke| Horiguchi, Shigeru| Tsutsumi, Koichiro| Otsuka, Motoyuki|
Keywords clipping closure delayed bleeding endoscopic papillectomy
Published Date 2025
Publication Title Therapeutic Advances in Gastroenterology
Volume volume18
Publisher SAGE Publications
ISSN 1756-2848
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s), 2025.
File Version publisher
PubMed ID 40104325
DOI 10.1177/17562848251326450
Web of Science KeyUT 001447404800001
Related Url isVersionOf https://doi.org/10.1177/17562848251326450
FullText URL fulltext.pdf
Author Ohashi, Ayaka| Sakamoto, Hirotaka| Kuroda, Junpei| Kondo, Yohei| Kamei, Yasuhiro| Nonaka, Shigenori| Furukawa, Saya| Yamamoto, Sakiya| Satoh, Akira|
Published Date 2025-02-24
Publication Title Nature Communications
Volume volume16
Issue issue1
Publisher Nature Portfolio
Start Page 1757
ISSN 2041-1723
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39994199
DOI 10.1038/s41467-025-57055-7
Web of Science KeyUT 001430168800025
Related Url isVersionOf https://doi.org/10.1038/s41467-025-57055-7
FullText URL fulltext.pdf
Author Hisano, Hiroshi| Sakai, Hiroaki| Hamaoka, Mika| Munemori, Hiromi| Abe, Fumitaka| Meints, Brigid| Sato, Kazuhiro| Hayes, Patrick M.|
Keywords Hordeum vulgare Covered (hulled) Naked (hull-less) Genome editing CRISPR/Cas9 Transformation amenability
Published Date 2025-03-07
Publication Title Molecular Breeding
Volume volume45
Issue issue3
Publisher Springer Science and Business Media LLC
Start Page 32
ISSN 1380-3743
NCID AA1104032X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40061124
DOI 10.1007/s11032-025-01553-5
Web of Science KeyUT 001439388700001
Related Url isVersionOf https://doi.org/10.1007/s11032-025-01553-5
FullText URL fulltext.pdf
Author Kato, Kosuke| Akamatsu, Miki| Kakimaru, Saya| Koreishi, Mayuko| Takagi, Masahiro| Miyashita, Masahiro| Murata, Yoshiyuki| Nakamura, Yoshimasa| Satoh, Ayano| Tsujino, Yoshio|
Keywords AhR Xenobiotic responsive element StemRegenin 1 ARNT Atopic dermatitis Artemin
Published Date 2025-03
Publication Title Food and Chemical Toxicology
Volume volume197
Publisher Elsevier BV
Start Page 115301
ISSN 0278-6915
NCID AA10627174
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Authors.
File Version publisher
PubMed ID 39923831
DOI 10.1016/j.fct.2025.115301
Web of Science KeyUT 001427591400001
Related Url isVersionOf https://doi.org/10.1016/j.fct.2025.115301
FullText URL fulltext.pdf
Author Ooba, Hikaru| Maki, Jota| Masuyama, Hisashi|
Keywords Perinatal mental disorders Voice analysis Machine learning Screening Pregnant women
Published Date 2025-02-08
Publication Title Discover Mental Health
Volume volume5
Issue issue1
Publisher Springer Nature
Start Page 12
ISSN 2731-4383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39920468
DOI 10.1007/s44192-025-00138-0
Web of Science KeyUT 001415532800001
Related Url isVersionOf https://doi.org/10.1007/s44192-025-00138-0
JaLCDOI 10.18926/AMO/68356
FullText URL 79_1_031.pdf
Author Maeda, Shigeru| Pimkhaokham, Atiphan| Yoshida, Michihiro| Hosoi, Hiroki| Ohshima, Ayako| Kurisu, Ryoko| Utsumi, Nozomi| Higuchi, Hitoshi| Miyawaki, Takuya|
Abstract We retrospectively analyzed the safety of the use of articaine, an amide-type local anesthetic, in Japanese dental patients (n=300) treated in Thailand in 2015-2017. The dosage, adverse events (AEs) caused by local anesthesia, and treatment efficacy were examined. Articaine, which is safe for patients with liver impairments due to its unique metabolism, has not been thoroughly tested in Japan for doses above 5.1 mL. Eighty of the present patients had undergone root canal treatment (RCT), 71 underwent tooth extraction, and 149 underwent implant-related surgery. More than three articaine cartridges were used in 41 patients, and no AEs occurred in these cases. The only AE occurred in a 52-year-old woman who was treated with three cartridges and presented with what appeared to be hyperventilation syndrome; she later recovered and received her dental treatment as scheduled. Most treatments were completed with three or fewer cartridges, suggesting that this number is generally sufficient. Our findings, particularly the low AE risk even with doses exceeding three cartridges, support the potential applicability of the overseas recommended maximum dose of articaine (7 mg/kg) in Japanese patients. This conclusion is significant for advancing dental anesthetic practices and ensuring patient safety and treatment efficacy in Japan.
Keywords dental anesthesia local anesthesia drug-related side effect adverse reaction
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-02
Volume volume79
Issue issue1
Publisher Okayama University Medical School
Start Page 31
End Page 37
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40012157
Web of Science KeyUT 001440463800004
JaLCDOI 10.18926/AMO/68355
FullText URL 79_1_021.pdf
Author Yamamoto, Yasuhiro| Haraguchi, Takafumi| Matsuda, Kaori| Okazaki, Yoshio| Kimoto, Shin| Tanji, Nozomu| Matsumoto, Atsushi| Kobayashi, Yasuyuki| Mimura, Hidefumi| Hiraki, Takao|
Abstract We developed a machine learning model for predicting prostate cancer (PCa) grades using radiomic features of magnetic resonance imaging. 112 patients diagnosed with PCa based on prostate biopsy between January 2014 and December 2021 were evaluated. Logistic regression was used to construct two prediction models, one using radiomic features and prostate-specific antigen (PSA) values (Radiomics model) and the other Prostate Imaging-Reporting and Data System (PI-RADS) scores and PSA values (PI-RADS model), to differentiate high-grade (Gleason score [GS] ≥ 8) from intermediate or low-grade (GS < 8) PCa. Five imaging features were selected for the Radiomics model using the Gini coefficient. Model performance was evaluated using AUC, sensitivity, and specificity. The models were compared by leave-one-out cross-validation with Ridge regularization. Furthermore, the Radiomics model was evaluated using the holdout method and represented by a nomogram. The AUC of the Radiomics and PI-RADS models differed significantly (0.799, 95% CI: 0.712-0.869; and 0.710, 95% CI: 0.617-0.792, respectively). Using holdout method, the Radiomics model yielded AUC of 0.778 (95% CI: 0.552-0.925), sensitivity of 0.769, and specificity of 0.778. It outperformed the PI-RADS model and could be useful in predicting PCa grades, potentially aiding in determining appropriate treatment approaches in PCa patients.
Keywords prostate cancer machine learning prostate Imaging-Reporting and Data System radiomics Gleason score
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-02
Volume volume79
Issue issue1
Publisher Okayama University Medical School
Start Page 21
End Page 30
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40012156
Web of Science KeyUT 001440463800003
FullText URL fulltext.pdf
Author Matsumoto, Naomi| Mitsui, Takashi| Tamai, Kei| Hirota, Tomoya| Masuyama, Hisashi| Yorifuji, Takashi|
Keywords Cesarean delivery Delivery methods Long-term outcome Child development Outcome-wide approach
Published Date 2025-01-20
Publication Title Scientific Reports
Volume volume15
Issue issue1
Publisher Nature Portfolio
Start Page 2485
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39833288
DOI 10.1038/s41598-025-87043-2
Web of Science KeyUT 001402008500024
Related Url isVersionOf https://doi.org/10.1038/s41598-025-87043-2
Title Alternative Elucidation of plant-bacterial pathogen interactions for the control of bacterial blight on cruciferous crops
FullText URL srfa_114_021_025.pdf
Author Sakata, Nanami|
Abstract  Pseudomonas cannabina pv. alisalensis (Pcal), the causative agent of bacterial blight on cruciferous crops, is an economically important pathogen worldwide. We have conducted several studies on the interactions between plants and pathogenic bacteria to develop effective control strategies for this disease. Using forward and reverse genetics, we identified several virulence factors, including the type III secretion system, membrane transporters, transcriptional factors, and amino acid metabolism. Additionally, we emphasized the role of coronatine, a toxin produced by Pcal, which promotes stomatal reopening and suppresses salicylic acid accumulation in plants. We also examined plant defense mechanisms activated by one of the plant defense activators, acibenzolar-S-methyl (ASM). ASM enhanced stomatal-based defense, resulting in reduction of bacterial entry and disease development. Moreover, we explored innovative control strategies for bacterial disease and demonstrated that amino acids and cellulose nanofiber are efficient and environmentally friendly control strategies. These studies advance our understanding of plant-pathogen dynamics and offer promising, sustainable approaches for managing bacterial blight disease in cruciferous crops.
Keywords Plant pathogenic bacteria Pseudomonas Cruciferous Plant protection Stomata
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2025-02-01
Volume volume114
Start Page 21
End Page 25
ISSN 2186-7755
language Japanese
File Version publisher
FullText URL fulltext.pdf
Author Izumi, Mahiro| Hagiya, Hideharu| Otsuka, Yuki| Soejima, Yoshiaki| Fukushima, Shinnosuke| Shibata, Mitsunobu| Hirota, Satoshi| Koyama, Toshihiro| Otsuka, Fumio| Gofuku, Akio|
Keywords Infection prevention and control Medical-engineering collaboration
Published Date 2025-01
Publication Title American Journal of Infection Control
Volume volume53
Issue issue1
Publisher Elsevier BV
Start Page 65
End Page 69
ISSN 0196-6553
NCID AA10617749
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Author(s).
File Version publisher
PubMed ID 39127185
DOI 10.1016/j.ajic.2024.08.003
Web of Science KeyUT 001402079000001
Related Url isVersionOf https://doi.org/10.1016/j.ajic.2024.08.003
Author Nakaoka, Minori| Fukuchi, Hibiki| Ogoshi, Maho| Aizawa, Sayaka| Takeuchi, Sakae|
Keywords Feather Barbule Branching Chicken Yolk sac membrane Notochord
Note © 2025 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jan. 2026.|
Published Date 2025-03-15
Publication Title Gene
Volume volume941
Publisher Elsevier BV
Start Page 149244
ISSN 0378-1119
NCID AA00654385
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Elsevier B.V.
File Version author
PubMed ID 39800195
DOI 10.1016/j.gene.2025.149244
Web of Science KeyUT 001398894500001
Related Url isVersionOf https://doi.org/10.1016/j.gene.2025.149244
Title Alternative Precision Medicine for Patients with Renal Cell Carcinoma Based on Drug-metabolizing Enzyme Expression Levels
FullText URL fulltext.pdf
Author Matsumoto, Jun|
Keywords renal cell carcinoma (RCC) kidney CYP uridine diphosphate glucose (UDP)-glucuronosyltransferase metabolism
Published Date 2025-01-01
Publication Title YAKUGAKU ZASSHI
Volume volume145
Issue issue1
Publisher Pharmaceutical Society of Japan
Start Page 7
End Page 14
ISSN 0031-6903
NCID AN00284903
Content Type Journal Article
language Japanese
OAI-PMH Set 岡山大学
Copyright Holders © 2025 公益社団法人日本薬学会
File Version publisher
PubMed ID 39756928
DOI 10.1248/yakushi.24-00166
Web of Science KeyUT 001392549800002
Related Url isVersionOf https://doi.org/10.1248/yakushi.24-00166
FullText URL fulltext.pdf
Author Kuribayashi, Tadahiro| Kinoshita, Rie| Ninomiya, Kiichiro| Makimoto, Go| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| Toyooka, Shinichi| Sakaguchi, Masakiyo| Ohashi, Kadoaki|
Keywords S100A8/A9 Lung cancer Immune checkpoint inhibitors
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-025-87232-z|
Published Date 2025-01-20
Publication Title Scientific Reports
Volume volume15
Issue issue1
Publisher Nature Portfolio
Start Page 2577
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39833332
DOI 10.1038/s41598-025-87232-z
Web of Science KeyUT 001400880600002
Related Url isVersionOf https://doi.org/10.1038/s41598-025-87232-z
Author Kondo, Shinya| Okamoto, Kazuki| Sakata, Osami| Teranishi, Takashi| Kishimoto, Akira| Nagasaki, Takanori| Yamada, Tomoaki|
Note This fulltext file will be available in Jan. 2026.|
Published Date 2025-01-02
Publication Title Applied Physics Letters
Volume volume126
Issue issue1
Publisher AIP Publishing
Start Page 012901
ISSN 0003-6951
NCID AA00543431
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Author(s).
File Version publisher
DOI 10.1063/5.0244707
Web of Science KeyUT 001390832500001
Related Url isVersionOf https://doi.org/10.1063/5.0244707
FullText URL fulltext.pdf
Author Denno, Satoshi| Sugimoto, Takumi| Matoba, Koki| Hou, Yafei|
Keywords overloaded MIMO spatial multiplexing QR-decomposition precoding overloading ratio
Published Date 2024-08-01
Publication Title IEICE Transactions on Communications
Volume volumeE108-B
Issue issue1
Publisher Institute of Electrical and Electronics Engineers (IEEE)
Start Page 1
End Page 13
ISSN 1745-1345
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Institute of Electronics, Information and Communication Engineers
File Version publisher
DOI 10.23919/transcom.2023ebn0001
Web of Science KeyUT 001390221500001
Related Url isVersionOf https://doi.org/10.23919/transcom.2023ebn0001