
検索結果 851 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Vu, Thuy Ha| Nakamura, Keiichiro| Shigeyasu, Kunitoshi| Kashino, Chiaki| Okamoto, Kazuhiro| Kubo, Kotaro| Kamada, Yasuhiko| Masuyama, Hisashi| |
| キーワード | Apolipoprotein-B mRNA-editing complex 3B Endometriosis Apoptosis Potential therapeutic target |
| 備考 | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-76589-2| |
| 発行日 | 2024-10-23 |
| 出版物タイトル | Scientific Reports |
| 巻 | 14巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 24968 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 39443671 |
| DOI | 10.1038/s41598-024-76589-2 |
| Web of Science KeyUT | 001341352800136 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-024-76589-2 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamauchi, Toshihiro| Orito, Rintaro| Ebisu, Koji| Sato, Masaya| |
| キーワード | Android accessibility services malicious websites web-based attacks web security |
| 発行日 | 2024 |
| 出版物タイトル | IEEE Access |
| 巻 | 12巻 |
| 出版者 | Institute of Electrical and Electronics Engineers |
| 開始ページ | 153285 |
| 終了ページ | 153294 |
| ISSN | 2169-3536 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Authors. |
| 論文のバージョン | publisher |
| DOI | 10.1109/ACCESS.2024.3478748 |
| Web of Science KeyUT | 001340709500001 |
| 関連URL | isVersionOf https://doi.org/10.1109/ACCESS.2024.3478748 |
| JaLCDOI | 10.18926/AMO/67664 |
|---|---|
| フルテキストURL | 78_5_401.pdf |
| 著者 | Toyota, Yusuke| Uda, Kazuhiro| Shirabe, Komei| Moriwake, Tadashi| |
| 抄録 | Severe febrile thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease that is endemic in parts of eastern Asia. Few pediatric cases have been reported. We describe a case of SFTS in a seven-year-old girl who presented with prolonged fever and gastrointestinal symptoms. Leukopenia and thrombocytopenia on hematology, and a history of outdoor activity led us to diagnose SFTS, although the patient had no tick bite marks. We also review the literature and discuss the characteristics of pediatric SFTS. Physicians should consider SFTS in the differential diagnosis of fever with thrombocytopenia in children living in endemic areas. |
| キーワード | child tick-borne disease severe febrile thrombocytopenia syndrome zoonoses |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-10 |
| 巻 | 78巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 401 |
| 終了ページ | 405 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39467658 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsuo, Toshihiko| Kobayashi, Yasuyuki| Nishimura, Shingo| Yoshioka, Naoko| Takahashi, Yasushi| Iguchi, Yasutaka| |
| キーワード | Fungal endophthalmitis Intravitreal injection Fluconazole Nephrostomy Urinary tract infection Ureterolithiasis |
| 発行日 | 2024-11 |
| 出版物タイトル | Journal of Medical Cases |
| 巻 | 15巻 |
| 号 | 11号 |
| 出版者 | Elmer Press, Inc. |
| 開始ページ | 359 |
| 終了ページ | 366 |
| ISSN | 1923-4155 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The authors |
| 論文のバージョン | publisher |
| PubMed ID | 39421221 |
| DOI | 10.14740/jmc4302 |
| Web of Science KeyUT | 001408599800009 |
| 関連URL | isVersionOf https://doi.org/10.14740/jmc4302 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Koda, Masahide| Horinouchi, Toru| Oya, Nozomu| Aki, Morio| Iriki, Akihisa| Yoshida, Kazufumi| Ogawa, Yusuke| Kuga, Hironori| Nakao, Tomohiro| |
| キーワード | mental health pandemic psychological first aid psychosocial support |
| 発行日 | 2023-06-08 |
| 出版物タイトル | Psychiatry and Clinical Neurosciences Reports |
| 巻 | 2巻 |
| 号 | 2号 |
| 出版者 | Wiley |
| 開始ページ | e107 |
| ISSN | 2769-2558 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 38868135 |
| DOI | 10.1002/pcn5.107 |
| Web of Science KeyUT | 001319548800013 |
| 関連URL | isVersionOf https://doi.org/10.1002/pcn5.107 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fukui, Yusuke| Morihara, Ryuta| Hu, Xinran| Nakano, Yumiko| Yunoki, Taijun| Takemoto, Mami| Abe, Koji| Yamashita, Toru| |
| キーワード | CasRx Hippocampal neurogenesis In vivo direct reprogramming Ischemic stroke PHP.eB Ptbp1 Recognition memory |
| 備考 | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-71212-w| |
| 発行日 | 2024-09-03 |
| 出版物タイトル | Scientific Reports |
| 巻 | 14巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 20521 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 39227632 |
| DOI | 10.1038/s41598-024-71212-w |
| Web of Science KeyUT | 001305757100013 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-024-71212-w |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sumi, Tomonari| Harada, Kouji| |
| キーワード | post-acute sequelae of SARS-CoV-2 infection PASC long Covid persistent viruses vaccine antiviral drug mathematical model immune response |
| 発行日 | 2024-08-09 |
| 出版物タイトル | Frontiers in Immunology |
| 巻 | 15巻 |
| 出版者 | Frontiers Media |
| 開始ページ | 1329162 |
| ISSN | 1664-3224 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Sumi and Harada. |
| 論文のバージョン | publisher |
| PubMed ID | 39185419 |
| DOI | 10.3389/fimmu.2024.1329162 |
| Web of Science KeyUT | 001295899400001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fimmu.2024.1329162 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sa'diyah, Wasiatus| Zhao, Yan-Jie| Chiba, Yuto| Kondo, Hideki| Suzuki, Nobuhiro| Ban, Sayaka| Yaguchi, Takashi| Urayama, Syun-Ichi| Hagiwara, Daisuke| |
| キーワード | Rhizopus microsporus RNA virus diversity new lineage FLDS |
| 発行日 | 2024-07-29 |
| 出版物タイトル | mSphere |
| 巻 | 9巻 |
| 号 | 8号 |
| 出版者 | American Society for Microbiology |
| ISSN | 2379-5042 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Sa'diyah et al. |
| 論文のバージョン | publisher |
| PubMed ID | 39072615 |
| DOI | 10.1128/msphere.00345-24 |
| Web of Science KeyUT | 001280103000001 |
| 関連URL | isVersionOf https://doi.org/10.1128/msphere.00345-24 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsuo, Toshihiko| Ikeda, Naoto| Monobe, Yasumasa| Tanaka, Takehiro| |
| キーワード | Janus kinase inhibitor Ruxolitinib Anemia Myelofibrosis Anterior uveitis |
| 発行日 | 2024-08 |
| 出版物タイトル | Journal of Medical Cases |
| 巻 | 15巻 |
| 号 | 8号 |
| 出版者 | Elmer Press, Inc. |
| 開始ページ | 208 |
| 終了ページ | 214 |
| ISSN | 1923-4155 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The authors |
| 論文のバージョン | publisher |
| PubMed ID | 39091577 |
| DOI | 10.14740/jmc4274 |
| Web of Science KeyUT | 001302104600009 |
| 関連URL | isVersionOf https://doi.org/10.14740/jmc4274 |
| フルテキストURL | fulltext20240701-03.pdf |
|---|---|
| 著者 | Sato, Yukiyo| Kondo, Hideki| Suzuki, Nobuhiro| |
| キーワード | RNAi Argonaute Dicer fungal virus chestnut blight |
| 備考 | This is an Accepted Manuscript of an article published by National Academy of Sciences.| This fulltext file will be available in Dec. 2024.| |
| 発行日 | 2024-06-12 |
| 出版物タイトル | Proceedings of the National Academy of Sciences |
| 巻 | 121巻 |
| 号 | 25号 |
| 出版者 | National Academy of Sciences |
| 開始ページ | e2322765121 |
| ISSN | 0027-8424 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 the Author(s). |
| 論文のバージョン | author |
| PubMed ID | 38865263 |
| DOI | 10.1073/pnas.2322765121 |
| Web of Science KeyUT | 001250384400007 |
| 関連URL | isVersionOf https://doi.org/10.1073/pnas.2322765121 |
| フルテキストURL | fulltext20240701-02.pdf |
|---|---|
| 著者 | Telengech, Paul| Hyodo, Kiwamu| Ichikawa, Hiroaki| Kuwata, Ryusei| Kondo, Hideki| Suzuki, Nobuhiro| |
| キーワード | cross- kingdom infection partitivirus fungal virus Plantae Animalia |
| 備考 | This is an Accepted Manuscript of an article published by National Academy of Sciences.| This fulltext file will be available in Dec. 2024.| |
| 発行日 | 2024-06-12 |
| 出版物タイトル | Proceedings of the National Academy of Sciences |
| 巻 | 121巻 |
| 号 | 25号 |
| 出版者 | National Academy of Sciences |
| 開始ページ | e2318150121 |
| ISSN | 0027-8424 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 the Author(s). |
| 論文のバージョン | author |
| PubMed ID | 38865269 |
| DOI | 10.1073/pnas.2318150121 |
| Web of Science KeyUT | 001250384400004 |
| 関連URL | isVersionOf https://doi.org/10.1073/pnas.2318150121 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sakamoto, Hirotaka| Inutsuka, Ayumu| |
| キーワード | GFP with a palmitoylation signal (palGFP) plasmalemma localization neurosecretory vesicle immunoelectron microscopy oxytocin |
| 発行日 | 2024-04-25 |
| 出版物タイトル | ACTA HISTOCHEMICA ET CYTOCHEMICA |
| 巻 | 57巻 |
| 号 | 2号 |
| 出版者 | The Japan Society of Histochemistry and Cytochemistry |
| 開始ページ | 85 |
| 終了ページ | 88 |
| ISSN | 0044-5991 |
| NCID | AA00508022 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Japan Society of Histochemistry and Cytochemistry |
| 論文のバージョン | publisher |
| PubMed ID | 38695035 |
| DOI | 10.1267/ahc.24-00001 |
| Web of Science KeyUT | 001223234800003 |
| 関連URL | isVersionOf https://doi.org/10.1267/ahc.24-00001 |
| フルテキストURL | fulltext20240512-01.pdf |
|---|---|
| 著者 | Zhai, Yun| Morihara, Ryuta| Feng, Tian| Hu, Xinran| Fukui, Yusuke| Bian, Zhihong| Bian, Yuting| Yu, Haibo| Sun, Hongming| Takemoto, Mami| Nakano, Yumiko| Yunoki, Taijun| Tang, Ying| Ishiura, Hiroyuki| Yamashita, Toru| |
| キーワード | Alzheimer's disease Hypoperfusion Cerebral vascular remodeling Scallop-derived plasmalogen pSTAT3/PIM1/NFATc1 axis |
| 備考 | © 2024 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jan. 2025.| |
| 発行日 | 2024-04-01 |
| 出版物タイトル | Brain Research |
| 巻 | 1828巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 148790 |
| ISSN | 0006-8993 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Elsevier B.V. |
| 論文のバージョン | author |
| PubMed ID | 38272156 |
| DOI | 10.1016/j.brainres.2024.148790 |
| Web of Science KeyUT | 001173928400001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.brainres.2024.148790 |
| フルテキストURL | fulltext20240508-02.pdf fig20240508-02.pdf table20240508-02.pdf |
|---|---|
| 著者 | Kitamura, Wataru| Kobayashi, Hiroki| Noda, Minori| Iseki, Akiko| Sato, Yumi| Maeda, Yoshinobu| Kuyama, Shoichi| |
| キーワード | Plasmacytoma Epstein–Barr virus Spontaneous regression |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12185-024-03765-5| This fulltext file will be available in Apr. 2025.| |
| 発行日 | 2024-04-15 |
| 出版物タイトル | International Journal of Hematology |
| 巻 | 120巻 |
| 号 | 1号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 128 |
| 終了ページ | 134 |
| ISSN | 0925-5710 |
| NCID | AA10797094 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Japanese Society of Hematology 2024 |
| 論文のバージョン | author |
| PubMed ID | 38619657 |
| DOI | 10.1007/s12185-024-03765-5 |
| Web of Science KeyUT | 001204755500002 |
| 関連URL | isVersionOf https://doi.org/10.1007/s12185-024-03765-5 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Mitsuhashi, Toshiharu| |
| キーワード | COVID-19 Metabolic syndrome Healch check up Conditional average treatment effect CATE Public health Pandemic |
| 発行日 | 2024-04-05 |
| 出版物タイトル | PeerJ |
| 巻 | 12巻 |
| 出版者 | PeerJ |
| 開始ページ | e17013 |
| ISSN | 2167-8359 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Mitsuhashi |
| 論文のバージョン | publisher |
| PubMed ID | 38590703 |
| DOI | 10.7717/peerj.17013 |
| Web of Science KeyUT | 001203244800004 |
| 関連URL | isVersionOf https://doi.org/10.7717/peerj.17013 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| フルテキストURL | 78_2_151.pdf |
| 著者 | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| 抄録 | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| キーワード | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 151 |
| 終了ページ | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688833 |
| Web of Science KeyUT | 001229151800007 |
| JaLCDOI | 10.18926/AMO/66914 |
|---|---|
| フルテキストURL | 78_2_115.pdf |
| 著者 | Nakamura-Maruyama, Emi| Irie, Keiichiro| Narita, Kazuhiko| Himi, Naoyuki| Miyamoto, Osamu| Nakamura, Takehiro| |
| 抄録 | Brain edema causes abnormal fluid retention and can be fatal in severe cases. Although it develops in various diseases, most treatments for brain edema are classical. We analyzed the impacts of age and gender on the characteristics of a water intoxication model that induces pure brain edema in mice and examined the model’s usefulness for research regarding new treatments for brain edema. C57BL/6J mice received an intraperitoneal administration of 10% body weight distilled water, and we calculated the brain water content by measuring the brain-tissue weight immediately after dissection and after drying. We analyzed 8-OHdG and caspase-3 values to investigate the brain damage. We also applied this model in aquaporin 4 knockout (AQP4−) mice and compared these mice with wild-type mice. The changes in water content differed by age and gender, and the 8-OHdG and caspase-3 values differed by age. Suppression of brain edema by AQP4− was also confirmed. These results clarified the differences in the onset of brain edema by age and gender, highlighting the importance of considering the age and gender of model animals. Similar studies using genetically modified mice are also possible. Our findings indicate that this water intoxication model is effective for explorations of new brain edema treatments. |
| キーワード | brain edema water intoxication model age gender AQP4 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 115 |
| 終了ページ | 122 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688829 |
| Web of Science KeyUT | 001229151800003 |
| JaLCDOI | 10.18926/AMO/66913 |
|---|---|
| フルテキストURL | 78_2_107.pdf |
| 著者 | Han, Dongxiang| Du, Jianxiu| Wang, Wei| Wang, Cui| |
| 抄録 | Vertical transmission of hepatitis B virus (HBV), especially in Asia, is a key target in the global elimination of HBV. This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. There were no significant differences in liver function markers, including alanine aminotransferase, total bilirubin, blood creatinine, and blood urea nitrogen levels before and after TDF treatment. The serum HBV DNA viral load of the TDF-treated group became significantly lower than those of the control group and their own pre-medication levels. Infants showed no significant difference in body growth, including weight, height, head size, and five-min Apgar score. At 7 months after birth, 94.29% of infants in the TDF group and 86.54% of control-group infants had protective HBsAb levels ≥ 10 mIU/ml (p>0.05). The HBV infection rate of infants in the TDF-treated group was lower than that in the non-treated group. In high-HBV-DNA-load pregnant women, TDF administered from 28 weeks gestational age to delivery was associated with a lower risk of mother-to-infant transmission of HBV. |
| キーワード | mother-to-infant transmission tenofovir disoproxil fumarate hepatitis B virus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 107 |
| 終了ページ | 113 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688828 |
| Web of Science KeyUT | 001229151800002 |
| JaLCDOI | 10.18926/AMO/66912 |
|---|---|
| フルテキストURL | 78_2_095.pdf |
| 著者 | Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
| 抄録 | The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. |
| キーワード | neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 95 |
| 終了ページ | 106 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688827 |
| Web of Science KeyUT | 001229151800001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sasaki, Shigenori| Ogawa, Hirohito| Katoh, Hirokazu| Honda, Tomoyuki| |
| キーワード | antiviral antivirals Borna disease virus CRISPR/Cas13b persistent infection |
| 発行日 | 2024-03-20 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 25巻 |
| 号 | 6号 |
| 出版者 | MDPI |
| 開始ページ | 3523 |
| ISSN | 1661-6596 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 38542493 |
| DOI | 10.3390/ijms25063523 |
| Web of Science KeyUT | 001192979100001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms25063523 |