検索結果 - 岡山大学学術成果リポジトリ

Effect of Deuterated Drugs on Safety: Insights from Pharmacovigilance Data Analysis

フルテキストURL	fulltext.pdf
著者	Kitagawa, Kohei\| Nawa, Hideki\| Asai, Shota\| Iwata, Naohiro\| Niimura, Takahiro\| Hamano, Hirofumi\| Goda, Mitsuhiro\| Zamami, Yoshito\| Ishizawa, Keisuke\|
キーワード	deuterated drug VigiBase heavy drug safety advantage pharmacovigilance analysis
発行日	2026-06-20
出版物タイトル	Biological and Pharmaceutical Bulletin
巻	49巻
号	6号
出版者	Pharmaceutical Society of Japan
開始ページ	983
終了ページ	988
ISSN	0918-6158
NCID	AA10885497
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 The Author(s).
論文のバージョン	publisher
PubMed ID	42324134
DOI	10.1248/bpb.b25-00768
CRID	1390027188280544896
関連URL	isVersionOf https://doi.org/10.1248/bpb.b25-00768

Successful Lung Transplantation after Plasma Exchange in a Patient with High Thermal Amplitude Cold Agglutinins: A Case Report

フルテキストURL	fulltext.pdf
著者	Miyoshi, Yuya\| Miyoshi, Kentaroh\| Asano, Naomi\| Yamamoto, Haruchika\| Tanaka, Shin\| Okahara, Shuji\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Fujii, Nobuharu\| Toyooka, Shinichi\|
キーワード	cold agglutinins thermal amplitude lung transplantation plasma exchange extracorporeal circulation perioperative management
発行日	2026
出版物タイトル	Surgical Case Reports
巻	12巻
号	1号
出版者	Japan Surgical Society
開始ページ	cr.26-0502
ISSN	2198-7793
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 The Author(s).
論文のバージョン	publisher
PubMed ID	42662700
DOI	10.70352/scrj.cr.26-0502
CRID	1390309372283822848
関連URL	isVersionOf https://doi.org/10.70352/scrj.cr.26-0502

Long-term and multi-stage ice accumulation in the martian mid-latitudes during the Amazonian

フルテキストURL	fulltext.pdf
著者	Ruj, Trishit\| Okuda, Hanaya\| Komatsu, Goro\| Hasegawa, Hitoshi\| Head, James W.\| Usui, Tomohiro\| Mihira, Shun\| Kobayashi, Makito\|
発行日	2025-09-02
出版物タイトル	Geology
巻	53巻
号	11号
出版者	Geological Society of America
開始ページ	945
終了ページ	950
ISSN	0091-7613
NCID	AA00656697
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Authors
論文のバージョン	publisher
DOI	10.1130/g53418.1
Web of Science KeyUT	001568788200001
関連URL	isVersionOf https://doi.org/10.1130/g53418.1

Peripheral Blood T-Cell Receptor Repertoire and Host Immune Background in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

JaLCDOI	10.18926/AMO/70852
フルテキストURL	80_3_169.pdf
著者	Nakamura, Yuki\| Iwamoto, Takayuki\| Kajiwara, Yukiko\| Hida, Akira\| Nakamoto, Shogo\| Miyoshi, Yuichiro\| Shien, Tadahiko\| Ikeda, Masahiko\| Doihara, Hiroyoshi\| Ogata, Ryohei\| Koike, Yoshikazu\| Nomura, Tsunehisa\| Tanaka, Katsuhiro\| Nakashima, Kazutaka\| Yamatsuji, Tomoki\| Taira, Naruto\|
抄録	The association between peripheral blood T-cell receptor (TCR) repertoire and chemotherapy response remains unclear. We evaluated peripheral blood TCR repertoire and gut microbiota in 21 breast cancer patients receiving neoadjuvant chemotherapy (NAC) who were enrolled in the SBP-14 prospective cohort study between October 2019 and March 2022. We analyzed stool samples obtained pre-NAC and peripheral blood samples obtained pre- and post-NAC. The primary endpoint was the association between baseline peripheral blood TCR repertoire and treatment response. Eleven patients (52%) had hormone receptor-positive breast cancer. All patients received anthracyclines and taxanes, with anti-HER2 therapy for HER2-positive disease. TCR diversity (TCR alpha chain [TRA], p=0.095; TCR beta chain [TRB], p=0.051) and clonality (TRA, p=0.271; TRB, p=0.500) were not significantly associated with treatment response. Gut microbiota diversity was not correlated with TCR diversity (TRA: ρ=0.046, p=0.845; TRB: ρ=0.021, p=0.929); however, three bacterial orders (Erysipelotrichales, Bacillales, and Pasteurellales) were significantly associated with TCR repertoire. Baseline TCR repertoire was not associated with treatment response in this cohort of breast cancer patients.
キーワード	TCR repertoire gut microbiota neoadjuvant chemotherapy breast cancer
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2026-06
巻	80巻
号	3号
出版者	Okayama University Medical School
開始ページ	169
終了ページ	178
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	42374749
Web of Science KeyUT	001812989700002

Investigating the Detectability of Body Wave Phases From Tidal Ice Cracking Events on Titan With the Dragonfly Short-Period Seismometer

フルテキストURL	fulltext.pdf
著者	Delaroque, L.\| Kawamura, T.\| Lucas, A.\| Rodriguez, S.\| Onodera, K.\| Shiraishi, H.\| Yamada, R.\| Tanaka, S.\| Panning, M. P.\| Lorenz, R. D.\|
キーワード	body waves planetary seismology interior structure dragonfly mission icy moons Titan
発行日	2026-04
出版物タイトル	Journal of Geophysical Research: Planets
巻	131巻
号	4号
出版者	American Geophysical Union (AGU)
開始ページ	e2025JE009432
ISSN	2169-9097
NCID	AA10815334
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 The Author(s).
論文のバージョン	publisher
DOI	10.1029/2025je009432
関連URL	isVersionOf https://doi.org/10.1029/2025je009432

The effects of cold compresses on itching in patients with atopic dermatitis: A cross-over controlled pilot trial

JaLCDOI	10.18926/interdisciplinary/70325
フルテキストURL	interdisciplinary_6_1.pdf
著者	HIRAMI, Yuki\| HARADA, Nahoko\| ONO, Miho\| KODA, Masahide\| FUKAI, Kiyoko\|
抄録	This cross-over controlled trial aimed to evaluate the effectiveness and safety of two types of cold compresses (towels and ice packs) in alleviating itching among patients with atopic dermatitis. The study recruited 19 participants diagnosed with atopic dermatitis and suffering from chronic itching for over 6 months. Each participant received both types of cold compress interventions. Itching sensations were assessed repeatedly using a visual analogue scale before and after the application of the cold compress. The mean and standard deviation of itching scores for the towel intervention were 16.9 ± 19.1 (baseline) and 11.4 ± 16.1 (post-application). For the ice pack intervention, the scores were 13.6 ± 14.7 (baseline) and 6.2 ± 9.8 (post-application). Although there was a reduction in mean itching scores following the application of cold compresses, the differences were not statistically significant for either intervention. Despite the lack of statistical significance, this study suggests that cold compresses, which are user-friendly and inexpensive, may safely reduce subjective itching in patients with atopic dermatitis without causing pain or discomfort. However, further research with a larger sample size is needed to confirm these findings.
キーワード	Atopic Dermatitis Pruritus Cryotherapy Quality of Life Skin Temperature
出版物タイトル	統合科学
発行日	2026-03-31
巻	6巻
開始ページ	1
終了ページ	6
ISSN	2436-3227
言語	英語
論文のバージョン	publisher

Changes in Prescribing Patterns of Antiviral Drugs before and after Public Coverage Termination among Hospitalized COVID-19 Patients in Regional Hospitals in Japan: A Retrospective, Multicenter Study

JaLCDOI	10.18926/AMO/70073
フルテキストURL	80_1_055.pdf
著者	Akazawa, Hidemasa\| Hagiya, Hideharu\| Fukushima, Shinnosuke\| Yamamoto, Shohei\| Nakano, Yasuhiro\| Otsuka, Fumio\|
抄録	In Japan, antiviral agents for COVID-19 were freely available until September 2023 as part of national policy. This study evaluated changes in these agents’ prescribing patterns and the patient outcomes following the policy shift. We conducted a multicenter retrospective study at four hospitals in Japan’s Okayama and Kagawa prefectures from January 2022 to March 2024. The study period was divided into the public-expenditure phase (January 2022 to September 2023) and the post-expenditure phase (October 2023 to March 2024). We extracted the hospitalized patients’ clinical data from the electronic database. The study’s primary outcome was the antiviral prescription rate; the secondary outcome was in-hospital mortality. Among the 302 hospitalized patients (median age 85 years), 52.0% were classified as having a mild condition. Of the patients with mild conditions, 37.7% were diagnosed in outpatient settings prior to hospitalization. During the public-expenditure phase, 47.4% of the patients received antivirals as outpatients, mainly molnupiravir (80.9%). In the post-expenditure period, 80.0% of the patients were prescribed antivirals, mostly molnupiravir (91.7%). The antiviral prescription rate was significantly higher after the policy change. The overall in-hospital mortality was 15.8%, with no significant difference between the two periods (17.0% vs. 10.5%). Despite the termination of government funding, antiviral prescriptions remained frequent at community hospitals located in highly aging regions of western Japan such as Okayama and Kagawa prefectures. Mortality remains high among the elderly, highlighting the need for continued antiviral therapy and booster vaccinations.
キーワード	coronavirus disease 2019 public expenditure prescribing pattern prognosis Japan
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2026-02
巻	80巻
号	1号
出版者	Okayama University Medical School
開始ページ	55
終了ページ	62
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	41748150
Web of Science KeyUT	001712994500007

Polyphyletic domestication and inter-lineage hybridization magnified genetic diversity of cultivated melon, Cucumis melo L.

フルテキストURL	fulltext.pdf
著者	Tanaka, Katsunori\| Shigita, Gentaro\| Dung, Tran Phuong\| Nhi, Phan Thi Phuong\| Takahashi, Mami\| Monden, Yuki\| Nishida, Hidetaka\| Ishikawa, Ryuji\| Kato, Kenji\|
キーワード	chloroplast genome Cucumis melo domestication genetic diversity melon molecular polymorphism seed size
発行日	2025
出版物タイトル	Breeding Science
巻	75巻
号	3号
出版者	Japanese Society of Breeding
開始ページ	168
終了ページ	178
ISSN	1344-7610
NCID	AA11353132
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 Japanese Society of Breeding.
論文のバージョン	publisher
PubMed ID	41000279
DOI	10.1270/jsbbs.24045
CRID	1390304869794855936
Web of Science KeyUT	001508328900001
関連URL	isVersionOf https://doi.org/10.1270/jsbbs.24045

Efficacy of diagnosing intraductal papillary mucinous neoplasm with mural nodules by contrast-enhanced endoscopic ultrasound using time–intensity curve analysis with a new support program: A multicenter retrospective study (with video)

フルテキストURL	fulltext.pdf
著者	Miyamoto, Kazuya\| Uchida, Daisuke\| Matsumoto, Kazuyuki\| Saragai, Yosuke\| Ogawa, Tsuneyoshi\| Ueki, Toru\| Harada, Kei\| Hattori, Nao\| Obata, Taisuke\| Sato, Ryosuke\| Matsumi, Akihiro\| Terasawa, Hiroyuki\| Fujii, Yuki\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Uemoto, Soichiro\| Tanimoto, Takayoshi\| Ohto, Akimitsu\| Otsuka, Motoyuki\|
キーワード	Endoscopic ultrasonography Pancreatic intraductal papillary mucinous neoplasm Neoplasm grading Contrast agent
発行日	2025-11
出版物タイトル	Pancreatology
巻	25巻
号	7号
出版者	Elsevier BV
開始ページ	1103
終了ページ	1108
ISSN	1424-3903
NCID	AA11583711
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Authors.
論文のバージョン	publisher
PubMed ID	41067982
DOI	10.1016/j.pan.2025.09.035
Web of Science KeyUT	001621423300004
関連URL	isVersionOf https://doi.org/10.1016/j.pan.2025.09.035

Bladder Trigone as a Sensory Hub: A Narrative Review

フルテキストURL	fulltext.pdf
著者	Sadahira, Takuya\| Maruyama, Yuki\| Mitsui, Yosuke\| Sekito, Takanori\| Watanabe, Tomofumi\| Watanabe, Masami\|
キーワード	bladder trigone botulinum toxin lower urinary tract symptoms sensory afferents varicosities
発行日	2025-10-19
出版物タイトル	Cureus
巻	17巻
号	10号
出版者	Springer Science and Business Media LLC
開始ページ	e94951
ISSN	2168-8184
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Copyright 2025 Sadahira et al.
論文のバージョン	publisher
PubMed ID	41267700
DOI	10.7759/cureus.94951
関連URL	isVersionOf https://doi.org/10.7759/cureus.94951

Molecular polymorphisms of the nuclear and chloroplast genomes among African melon germplasms reveal abundant and unique genetic diversity, especially in Sudan

フルテキストURL	fulltext.pdf suppl1.xlsx suppl2.xlsx suppl3.xlsx suppl4.xlsx suppl5.xlsx suppl6.xlsx suppl7.pptx suppl8.pptx suppl9.pptx
著者	Imoh, Odirichi Nnennaya\| Shigita, Gentaro\| Sugiyama, Mitsuhiro\| Dung, Tran Phuong\| Tanaka, Katsunori\| Takahashi, Mami\| Nishimura, Kazusa\| Monden, Yuki\| Nishida, Hidetaka\| Goda, Mashaer\| Pitrat, Michel\| Kato, Kenji\|
キーワード	Cucumis melo Africa chloroplast genome domestication genetic diversity genetic resources maternal lineage melon phylogeny polyphyletic origin seed size Tibish
発行日	2025-04-17
出版物タイトル	Annals of Botany
巻	135巻
号	7号
出版者	Oxford University Press (OUP)
開始ページ	1329
終了ページ	1343
ISSN	0305-7364
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2025.
論文のバージョン	publisher
PubMed ID	40244644
DOI	10.1093/aob/mcaf028
Web of Science KeyUT	001484819500001
関連URL	isVersionOf https://doi.org/10.1093/aob/mcaf028

Lymphadenectomy and chemotherapy are effective treatments for patients with 2023 international federation of gynecology and obstetrics stage IIC-high risk endometrial cancer in Japan

フルテキストURL	fulltext.pdf
著者	Tani, Yoshinori\| Nakamura, Keiichiro\| Yorimitsu, Masae\| Seki, Noriko\| Nakanishi, Mie\| Itou, Hironori\| Shimizu, Miyuki\| Yamamoto, Dan\| Takahara, Etsuko\| Masuyama, Hisashi\|
キーワード	Endometrial cancer FIGO 2023 Stage IIC high risk Lymphadenectomy Chemotherapy
備考	The version of record of this article, first published in International Journal of Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10147-024-02647-4\|
発行日	2024-11-09
出版物タイトル	International Journal of Clinical Oncology
巻	30巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	144
終了ページ	156
ISSN	1341-9625
NCID	AA11086579
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	39516301
DOI	10.1007/s10147-024-02647-4
Web of Science KeyUT	001351172500001
関連URL	isVersionOf https://doi.org/10.1007/s10147-024-02647-4

Unraveling the Cr Isotopes of Ryugu: An Accurate Aqueous Alteration Age and the Least Thermally Processed Solar System Material

フルテキストURL	fulltext.pdf
著者	Tanaka, Ryoji\| Ratnayake, Dilan M.\| Ota, Tsutomu\| Miklusicak, Noah\| Kunihiro, Tak\| Potiszil, Christian\| Sakaguchi, Chie\| Kobayashi, Katsura\| Kitagawa, Hiroshi\| Yamanaka, Masahiro\| Abe, Masanao\| Miyazaki, Akiko\| Nakato, Aiko\| Nakazawa, Satoru\| Nishimura, Masahiro\| Okada, Tatsuaki\| Saiki, Takanao\| Tanaka, Satoshi\| Terui, Fuyuto\| Tsuda, Yuichi\| Usui, Tomohiro\| Watanabe, Sei-ichiro\| Yada, Toru\| Yogata, Kasumi\| Yoshikawa, Makoto\| Nakamura, Eizo\|
発行日	2024-04-04
出版物タイトル	The Astrophysical Journal
巻	965巻
号	1号
出版者	American Astronomical Society
開始ページ	52
ISSN	0004-637X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024. The Author(s).
論文のバージョン	publisher
DOI	10.3847/1538-4357/ad276a
Web of Science KeyUT	001197227200001
関連URL	isVersionOf https://doi.org/10.3847/1538-4357/ad276a

LeFood-set: Baseline performance of predicting level of leftovers food dataset in a hospital using MT learning

フルテキストURL	fulltext.pdf
著者	Sari, Yuita Arum\| Nakazawa, Atsushi\| Wani, Yudi Arimba\|
発行日	2025-05-19
出版物タイトル	PLoS One
巻	20巻
号	5号
出版者	Public Library of Science
開始ページ	e0320426
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 Sari et al.
論文のバージョン	publisher
PubMed ID	40388400
DOI	10.1371/journal.pone.0320426
Web of Science KeyUT	001491376800016
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0320426

A Case of Chromophobe Renal Cell Carcinoma Metastasizing to the Cervical Lymph Nodes after Long-term Follow-up

JaLCDOI	10.18926/AMO/68730
フルテキストURL	79_3_213.pdf
著者	Watanabe, Makoto\| Ogawa, Tomoyuki\| Kobayashi, Kanao\| Katsuya, Narutaka\| Ishikawa, Akira\| Hamamoto, Takao\| Tahara, Hiroaki\| Ueda, Tsutomu\| Takeno, Sachio\|
抄録	Renal cell carcinoma (RCC) can metastasize hematogenously and recur after a long dormancy. Chromophobe RCC metastasized to the cervical lymph nodes 10 years after the primary resection in a woman who underwent nephrectomy for RCC (T1aN0M0 stage I). Metastatic RCC diagnosis was confirmed by aspiration. The lymph node mass was resected, and the tumor cells matched chromophobe RCC metastasis. No adjuvant therapy was administered due to the lack of evidence regarding adjuvant therapy for chromophobe RCC. Long-term surveillance is crucial in RCC because of the possibility of late metastasis. We reviewed the clinical aspects and literature on metastatic cervical RCC.
キーワード	renal cell carcinoma cervical lymph node metastasis late recurrence head and neck
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2025-06
巻	79巻
号	3号
出版者	Okayama University Medical School
開始ページ	213
終了ページ	219
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	40574261
Web of Science KeyUT	001524768800009

Droplet Impact Behavior on Convex Surfaces with a Circumferential Wettability Difference

フルテキストURL	fulltext20250324-01.pdf
著者	Ishikawa, Taku\| Yamada, Yutaka\| Isobe, Kazuma\| Horibe, Akihiko\|
備考	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © 2025 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.langmuir.4c05316.\| This fulltext file will be available in Mar. 2026.\|
発行日	2025-03-12
出版物タイトル	Langmuir
巻	41巻
号	11号
出版者	American Chemical Society (ACS)
開始ページ	7640
終了ページ	7647
ISSN	0743-7463
NCID	AA10461730
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 American Chemical Society
論文のバージョン	author
PubMed ID	40074711
DOI	10.1021/acs.langmuir.4c05316
Web of Science KeyUT	001444246100001
関連URL	isVersionOf https://doi.org/10.1021/acs.langmuir.4c05316

Palliative Gamma Knife Radiosurgery for a Small Part of a Large Vestibular Schwannoma in an Elderly Patient

JaLCDOI	10.18926/AMO/67207
フルテキストURL	78_3_301.pdf
著者	Nakazaki, Kiyoshi\| Hirai, Satoshi\| Hishikawa, Tomohito\|
抄録	We report a case of a large vestibular schwannoma in an 80-year-old female patient that shrank after palliative Gamma Knife radiosurgery (GKS). Neurological symptoms included hearing deterioration and facial palsy. The tumor volume was 21.9 mL. Craniotomy was considered high-risk, and conventional GKS was risky, owing to the risk of transient enlargement. Therefore, GKS was performed on only a portion of the tumor. The marginal dose (12 Gy) volume was 3.8 mL (17.4%). The tumor began to shrink after transient enlargement. Sixty months later, the tumor volume was only 3.1 mL, and the patient was able to maintain independent activities of daily living without salvage treatment.
キーワード	vestibular schwannoma Gamma Knife radiosurgery large volume palliative elderly patient
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	301
終了ページ	306
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902220
Web of Science KeyUT	001267340600001

p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression

JaLCDOI	10.18926/AMO/66924
フルテキストURL	78_2_151.pdf
著者	Komatsubara, Tadashi\| Tazawa, Hiroshi\| Hasei, Joe\| Omori, Toshinori\| Sugiu, Kazuhisa\| Mochizuki, Yusuke\| Demiya, Koji\| Yoshida, Aki\| Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
抄録	Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
キーワード	soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	151
終了ページ	161
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688833
Web of Science KeyUT	001229151800007

Impact of Travel Distance on Surgical Outcomes of Patients Surgically Treated for Non-Small Cell Lung Cancer: A Single-Center Study in Ehime, Japan

JaLCDOI	10.18926/AMO/66923
フルテキストURL	78_2_143.pdf
著者	Shigematsu, Hisayuki\| Yamashita, Natsumi\| Suehisa, Hiroshi\| Ueno, Tsuyoshi\| Ryuko, Tsuyoshi\| Sugihara, Takahito\| Nakashima, Shohei\| Sano, Yoshifumi\| Yamashita, Motohiro\|
抄録	Travel burden is a poor prognostic factor for many cancers worldwide because it hinders optimal diagnosis and treatment planning. Currently, the impact of travel burden on survival after surgery for non-small cell lung cancer (NSCLC) in Japan is largely unexplored. We examined the impact of travel distance on the postoperative outcomes of patients with NSCLC in Ehime Prefecture, Japan. The data of 1212 patients who underwent surgical resection for NSCLC were retrospectively reviewed. Patients were divided into quartiles based on the travel distance from their home to the hospital (≤ 13 km, 13-40 km, 40-57 km, and > 57 km) in Ehime Prefecture. We found no significant differences among the quartiles in baseline clinicopathological characteristics, including sex, smoking status, histology, surgical procedure, clinical stage, and pathological stage. Overall survival (OS) and relapse-free survival (RFS) also were not significantly different among the travel distance quartiles. We conclude that travel distance did not impact OS or RFS among patients with NSCLC who underwent surgical resection at our institution.
キーワード	non-small cell lung cancer travel distance travel burden lung surgery surgical outcome
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	143
終了ページ	149
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688832
Web of Science KeyUT	001229151800006

GenIce-core: Efficient algorithm for generation of hydrogen-disordered ice structures

フルテキストURL	fulltext.pdf
著者	Matsumoto, Masakazu\| Yagasaki, Takuma\| Tanaka, Hideki\|
備考	This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Masakazu Matsumoto, Takuma Yagasaki, Hideki Tanaka; GenIce-core: Efficient algorithm for generation of hydrogen-disordered ice structures. J. Chem. Phys. 7 March 2024; 160 (9): 094101. https://doi.org/10.1063/5.0198056 and may be found at https://doi.org/10.1063/5.0198056.\| This fulltext file will be available in Mar. 2025.\|
発行日	2024-03-01
出版物タイトル	The Journal of Chemical Physics
巻	160巻
号	9号
出版者	AIP Publishing
開始ページ	094101
ISSN	0021-9606
NCID	AA00694991
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Author(s).
論文のバージョン	publisher
PubMed ID	38426513
DOI	10.1063/5.0198056
Web of Science KeyUT	001178860800001
関連URL	isVersionOf https://doi.org/10.1063/5.0198056