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著者 Gotoh, Kazuma| Ishikawa, Toru| Shimadzu, Saori| Yabuuchi, Naoaki| Komaba, Shinichi| Takeda, Kazuyuki| Goto, Atsushi| Deguchi, Kenzo| Ohki, Shinobu| Hashi, Kenjiro| Shimizu, Tadashi| Ishida, Hiroyuki|
発行日 2013-03
出版物タイトル Journal of Power Sources
225巻
資料タイプ 学術雑誌論文
著者 Gotoh, Kazuma| Kinumoto, Taro| Fujii, Eiji| Yamamoto, Aki| Hashimoto, Hideki| Ohkubo, Takahiro| Itadani, Atsushi| Kuroda, Yasushige| Ishida, Hiroyuki|
発行日 2011-04
出版物タイトル Carbon
49巻
4号
資料タイプ 学術雑誌論文
著者 Gotoh, Kazuma| Takeda, Kazuyuki| Lerner, Michael M.| Sueishi, Yoshimi| Maruyama, Shinpei| Goto, Atsushi| Tansho, Masataka| Ohki, Shinobu| Hashi, Kenjiro| Shimizu, Tadashi| Ishida, Hiroyuki|
発行日 2011-10
出版物タイトル Carbon
49巻
12号
資料タイプ 学術雑誌論文
著者 Kanehara, Masayuki| Takeya, Jun| Uemura, Takafumi| Murata, Hideyuki| Takimiya, Kazuo| Sekine, Hikaru| Teranishi, Toshiharu|
発行日 2012-09
出版物タイトル Bulletin of the Chemical Society of Japan
85巻
9号
資料タイプ 学術雑誌論文
著者 Uma, Thanganathan| Nogami, Masayuki|
発行日 2009-04-01
出版物タイトル Journal of the Ceramic Society of Japan
117巻
1364号
資料タイプ 学術雑誌論文
著者 Watanabe, Koyo| Matsuura, Koji| Kawata, Fukukazu| Nagata, Kotaro| Ning, Jun| Kano, Hiroshi|
発行日 2012-02-01
出版物タイトル Biomedical Optics Express
3巻
2号
資料タイプ 学術雑誌論文
著者 Matsuura, Koji| Takenami, Mami| Kuroda, Yuka| Hyakutake, Toru| Yanase, Shinichiro| Naruse, Keiji|
発行日 2012-01
出版物タイトル Reproductive BioMedicine Online
24巻
1号
資料タイプ 学術雑誌論文
著者 Sano, Hikaru| Matsuura, Koji| Naruse, Keiji| Funahashi, Hiroaki|
発行日 2010-09-15
出版物タイトル Theriogenology
74巻
5号
資料タイプ 学術雑誌論文
著者 Koike, Takayuki| Matsuura, Koji| Naruse, Keiji| Funahashi, Hiroaki|
発行日 2010-10
出版物タイトル Journal of Reproduction and Development
56巻
5号
資料タイプ 学術雑誌論文
著者 Hyakutake, Toru| Hashimoto, Yuki| Yanase, Shinichiro| Matsuura, Koji| Naruse, Keiji|
発行日 2009-02
出版物タイトル Biomedical Microdevices
11巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/48965
フルテキストURL 66_5_409.pdf
著者 Sarai, Takaaki| Inoue, Takayuki| Fujiwara, Kazuo| Kuramoto, Koichi|
抄録 The human femur is subjected to an impulsive load at its distal end during daily life. Femoral bone fracture caused by impact loading is common in elderly women. It is important to clarify the dynamic response of the femur and to evaluate the change in its stress state during impact loading. A 3-dimensional model of the femur was prepared in the present study, and the impulsive stress waves propagating from the distal end of the femur were analyzed by the dynamic finite element method. This model showed that the von Mises equivalent stress is large on the anterior and posterior sides of the mid-diaphysis when the impact direction is different from that of the bone axis. As for the femoral neck, the absolute value of minimum principal stress initially increases on the medial side;slightly later the maximum principal stress increases on the lateral side. In this case, the absolute value of the maximum principal stress was found to be larger than that of the minimum principal stress, and the absolute value of the principal stress decreased as the impact angle increased. Further, the femoral neck and the trochanter were shown to have a higher risk of bone fracture when the impact direction is coincident with the bone axis.
キーワード biomechanics femur impulsive stress wave impact angle dynamic finite element analysis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-10
66巻
5号
出版者 Okayama University Medical School
開始ページ 409
終了ページ 415
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23093059
Web of Science KeyUT 000310253900005
JaLCDOI 10.18926/AMO/48964
フルテキストURL 66_5_399.pdf
著者 Jing, Shao-Wu| Wang, Ya-Di| Kuroda, Masahiro| Su, Jing-Wei| Sun, Guo-Gui| Liu, Qing| Cheng, Yun-Jie| Yang, Cong-Rong|
抄録 Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion and metastasis, but no study has reported its action in esophageal carcinoma. The goal of this study was to explore the probable mechanism of HIF-1α in the invasion and metastasis of esophageal carcinoma Eca109 cells in vitro and in vivo. mRNA and protein expression of HIF-1α, E-cadherin and matrix metalloproteinase-2 (MMP-2) under hypoxia were detected by RT-PCR and Western blotting. The effects of silencing HIF-1α on E-cadherin, MMP-2 mRNA and protein expression under hypoxia or normoxia were detected by RT-PCR and Western blotting, respectively. The invasive ability of Eca109 cells was tested using a transwell chambers. We established an Eca109-implanted tumor model and observed tumor growth and lymph node metastasis. The expression of HIF-1α, E-cadherin and MMP-2 in xenograft tumors was detected by Western blotting. After exposure to hypoxia, HIF-1α protein was up-regulated, both mRNA and protein levels of E-cadherin were down-regulated and MMP-2 was up-regulated, while HIF-1α mRNA showed no significant change. SiRNA could block HIF-1α effectively, increase E-cadherin expression and inhibit MMP-2 expression. The number of invading cells decreased after HIF-1α was silenced. Meanwhile, the tumor volume was much smaller, and the metastatic rate of lymph nodes and the positive rate were lower in vivo. Our observations suggest that HIF-1α inhibition might be an effective strategy to weaken invasion and metastasis in the esophageal carcinoma Eca109 cell line.
キーワード hypoxia-inducible factor-1α esophageal carcinoma invasion and metastasis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-10
66巻
5号
出版者 Okayama University Medical School
開始ページ 399
終了ページ 407
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23093058
Web of Science KeyUT 000310253900004
JaLCDOI 10.18926/AMO/48963
フルテキストURL 66_5_387.pdf
著者 Chikasue, Kumiko| Kimura, Miyuki| Ikeda, Kazuyuki| Ohnishi, Takuma| Kawanishi, Satoshi| Iio, Tomoe| Kataoka, Mikio| Arao, Yujiro|
抄録 To determine whether exhaled breath contains Torque teno virus (TTV) or not, we tested exhaled breath condensate (EBC) samples by semi-nested PCR assay. We detected TTV DNA in 35% (7/20) of EBC samples collected from the mouth of one of the authors, demonstrating that TTV DNA is excreted in exhaled breath with moderate frequency. TTV DNA was detected also in oral EBC samples from 4 of 6 other authors, indicating that TTV DNA excretion in exhaled breath is not an exception but rather a common phenomenon. Furthermore, the same assay could amplify TTV DNA from room air condensate (RAC) samples collected at distances of 20 and 40cm from a human face with 40 (8/20) and 35% (7/20) positive rates, respectively. TTV transmission has been reported to occur during infancy. These distances seem equivalent to that between an infant and its household members while caring for the infant. Taken together, it seems that exhaled breath is one of the possible transmission routes of TTV. We also detected TTV DNA in 25% (10/40) of RAC samples collected at a distance of more than 180cm from any human face, suggesting the risk of airborne infection with TTV in a room.
キーワード Torque teno virus exhaled breath airborne infection polymerase chain reaction
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2012-10
66巻
5号
出版者 Okayama University Medical School
開始ページ 387
終了ページ 397
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23093057
Web of Science KeyUT 000310253900003
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/49508
著者 Nishioka, Yasutaka| Suzumori, Koichi| Kanda, Takefumi| Wakimoto, Shuichi|
発行日 2010-12
出版物タイトル Sensors and Actuators A: Physical
164巻
1-2号
資料タイプ 学術雑誌論文
著者 Nagase, Jun-ya| Wakimoto, Shuichi| Satoh, Toshiyuki| Saga, Norihiko| Suzumori, Koichi|
発行日 2011-10
出版物タイトル Smart Materials and Structures
20巻
10号
資料タイプ 学術雑誌論文
著者 Wakimoto, Shuichi| Suzumori, Koichi| Ogura, Keiko|
発行日 2011
出版物タイトル Advanced Robotics
25巻
9-10号
資料タイプ 学術雑誌論文
著者 Faudzi, Ahmad 'Athif Mohd| Suzumori, Koichi| Wakimoto, Shuichi|
発行日 2010
出版物タイトル Advanced Robotics
24巻
10号
資料タイプ 学術雑誌論文
著者 小西 正躬| 中野 孝一| 今井 純|
発行日 2011-06-01
出版物タイトル 鉄と鋼
97巻
6号
資料タイプ 学術雑誌論文
著者 Itoh, Ryota| Nagataki, Hiroyuki| Ooshita, Fukuhito| Kakugawa, Hirotsugu| Masuzawa, Toshimitsu|
発行日 2007-07-10
出版物タイトル 8th International Conference on Information Technology Based Higher Education and Training
資料タイプ 会議発表論文
著者 Okazaki, Hiroyuki| Yoshida, Rikiya| Muro, Takayuki| Nakamura, Tetsuya| Wakita, Takanori| Muraoka, Yuji| Hirai, Masaaki| Kato, Hiromitsu| Yamasaki, Satoshi| Takano, Yoshihiko| Ishii, Satoshi| Oguchi, Tamio| Yokoya, Takayoshi|
発行日 2011-02-21
出版物タイトル Applied Physics Letters
98巻
8号
資料タイプ 学術雑誌論文