検索結果 3251 件
| タイトル（別表記） | Gene therapy using REIC/Dkk-3-encoding adenoviral vector for the treatment of malignant pleural mesothelioma |
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| フルテキストURL | 127_47.pdf |
| 著者 | 豊岡 伸一| |
| キーワード | 悪性胸膜中皮腫 REIC/DKK-3 遺伝子治療 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-04-01 |
| 巻 | 127巻 |
| 号 | 1号 |
| 開始ページ | 47 |
| 終了ページ | 50 |
| ISSN | 0030-1558 |
| 関連URL | http://www.okayama-u.ac.jp/user/oma/ |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.47 |
| NAID | 130005068349 |
| タイトル（別表記） | Laparoscopic repair of an abdominal incisional hernia above the pubis |
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| フルテキストURL | 127_31.pdf |
| 著者 | 中野 敢友| 井谷 史嗣| 淺海 信也| 大川 広| 吉本 匡志| 伊藤 雅典| 門田 一晃| 黒瀬 洋平| 日置 勝義| 石井 龍宏| 貞森 裕| 大野 聡| 金 仁洙| 高倉 範尚| |
| 抄録 | Laparoscopic repair of a suprapubic hernia typically carries a high risk of recurrence, because fixation of the mesh in the peripubic area is difficult. We herein report a patient undergoing laparoscopic repair of a suprapubic hernia, along with a description of the surgical techniques employed. A 78-year-old woman visited our hospital with a chief complaint of swelling at the median hypogastric incision site after surgery for an ovarian cyst performed at age 25 years. Laparoscopic examination revealed the hernia orifice to be 3.5×3.0 cm in size and that the distance between the caudal margin of the hernia orifice and the pubis was 2.5 cm. Parietex composite mesh was used for fixation through all layers of the abdominal wall with non-absorbable sutures and tack fixation. On the pubic side, after the pubis had been exposed by separating it from the bladder, we performed mesh fixation through all layers of the abdominal wall immediately above the pubis with the sutures placed inside the mesh, combined with tack mesh fixation directly to the pubis. This procedure enabled definite fixation of the mesh. Six days after surgery, she was discharged without complications. To date, two years and five months after surgery, no recurrence has been observed. |
| キーワード | 腹壁瘢痕ヘルニア（incisional hernia） 恥骨上ヘルニア（suprapubic hernia） 腹腔鏡下修復術（laparoscopic repair） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-04-01 |
| 巻 | 127巻 |
| 号 | 1号 |
| 開始ページ | 31 |
| 終了ページ | 34 |
| ISSN | 0030-1558 |
| 関連URL | http://www.okayama-u.ac.jp/user/oma/ |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.31 |
| NAID | 130005068354 |
| JaLCDOI | 10.18926/bgeou/53146 |
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| タイトル（別表記） | Characterization of Elementary School Districts – A model study in Himeji City – |
| フルテキストURL | bgeou_158_023_026.pdf |
| 著者 | 伊藤 武彦| 中山 いづみ| |
| 抄録 | この研究では，小学校の通学区域を国勢調査結果や住民基本台帳データのうち小学校の通 学区域（学区）別に編纂されているものを用いてそれらの類型化を試み，その結果を地図上 に表現した。そのような類型が生じる背景にある人口学的な性質を考察し，学校ごとに濃淡 がある児童生徒の種々の健康課題について，日常生活における背景を考察するためのツール としての可能性に言及した。 |
| キーワード | 国勢調査 住民基本台帳 通学区域 小地域分析 地理情報 |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2015-02-25 |
| 巻 | 158巻 |
| 開始ページ | 23 |
| 終了ページ | 26 |
| ISSN | 1883-2423 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005553916 |
| 著者 | Ishikawa, Hisashi| Takaki, Akinobu| Tsuzaki, Ryuichiro| Yasunaka, Tetsuya| Koike, Kazuko| Shimomura, Yasuyuki| Seki, Hiroyuki| Matsushita, Hiroshi| Miyake, Yasuhiro| Ikeda, Fusao| Shiraha, Hidenori| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
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| 発行日 | 2014-07-01 |
| 出版物タイトル | PLoS ONE |
| 巻 | 9巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Kobayashi, Junko| Yoshida, Masashi| Tarui, Suguru| Hirata, Masataka| Nagai, Yusuke| Kasahara, Shingo| Naruse, Keiji| Ito, Hiroshi| Sano, Shunji| Oh, Hidemasa| |
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| 発行日 | 2014-07-22 |
| 出版物タイトル | PLoS ONE |
| 巻 | 9巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| フルテキストURL | K0005074_abstract_review.pdf K0005074_fulltext.pdf |
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| 著者 | 石川 久| |
| 発行日 | 2014-12-31 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5074号 |
| 学位授与年月日 | 2014-12-31 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005073_abstract_review.pdf K0005073_fulltext.pdf |
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| 著者 | 平山 敬浩| |
| 発行日 | 2014-12-31 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5073号 |
| 学位授与年月日 | 2014-12-31 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005069_abstract_review.pdf K0005069_fulltext.pdf |
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| 著者 | 綿谷 博雪| |
| 発行日 | 2014-12-31 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5069号 |
| 学位授与年月日 | 2014-12-31 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 日本語 英語 |
| JaLCDOI | 10.18926/AMO/53117 |
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| フルテキストURL | 69_1_1.pdf |
| 著者 | Watatani, Hiroyuki| Yamasaki, Hiroko| Maeshima, Yohei| Nasu, Tatsuyo| Hinamoto, Norikazu| Ujike, Haruyo| Sugiyama, Hitoshi| Sakai, Yoshiki| Tanabe, Katsuyuki| Makino, Hirofumi| |
| 抄録 | Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells. |
| キーワード | prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-02 |
| 巻 | 69巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25703166 |
| Web of Science KeyUT | 000349740300001 |
| JaLCDOI | 10.18926/OER/53101 |
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| タイトル（別表記） | The Possibility of Real Estate Agent as a “Networker” on the Former Elementary School Site Development Project |
| フルテキストURL | oer_046_2_157_176.pdf |
| 著者 | 槇尾 啓一| |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2014-12-18 |
| 巻 | 46巻 |
| 号 | 2号 |
| 開始ページ | 157 |
| 終了ページ | 176 |
| ISSN | 0386-3069 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2014 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120005540379 |
| 著者 | Kikuchi, Satoru| Kishimoto, Hiroyuki| Tazawa, Hiroshi| Hashimoto, Yuuri| Kuroda, Shinji| Nishizaki, Masahiko| Nagasaka, Takeshi| Shirakawa, Yasuhiro| Kagawa, Shunsuke| Urata, Yasuo| Robert M Hoffman| Fujiwara, Toshiyoshi| |
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| 発行日 | 2014-12-19 |
| 出版物タイトル | Molecular Therapy |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 齋藤 昇| |
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| 発行日 | 2015-02-01 |
| 出版物タイトル | 岡山大学農学部学術報告 |
| 巻 | 104巻 |
| 資料タイプ | 紀要論文 |
| 著者 | Ishiwata, Satoshi| Kawabi, Hiroshi| Teruya, Tsubasa| |
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| 発行日 | 2015-01 |
| 出版物タイトル | Mathematical Journal of Okayama University |
| 巻 | 57巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/mjou/53045 |
| 著者 | Qi, Yan| |
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| 発行日 | 2015-01 |
| 出版物タイトル | Mathematical Journal of Okayama University |
| 巻 | 57巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/mjou/53043 |
| 著者 | Haraguchi, Tadayuki| |
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| 発行日 | 2015-01 |
| 出版物タイトル | Mathematical Journal of Okayama University |
| 巻 | 57巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/mjou/53040 |
| JaLCDOI | 10.18926/AMO/53024 |
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| フルテキストURL | 68_6_349.pdf |
| 著者 | Yamamoto, Tsuyoshi| Kajikawa, Yutaka| Otani, Satoru| Yamada, Yuki| Takemoto, Syunji| Hirota, Minoru| Ikeda, Masae| Iwagaki, Hiromi| Saito, Shinya| Fujiwara, Toshiyoshi| |
| 抄録 | Accumulated studies have shown that ω-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have protective roles against inflammatory responses such as hyperlipidemia, diabetes mellitus (DM) and cardiovascular diseases. Here we examined the effects of administering EPA to hyperlipidemic patients and other patients undergoing cardiac surgery to determine whether this treatment would increase plasma EPA levels and to clarify the association between EPA treatment and adiponectin production in hyperlipidemic patients. We also assessed the effect of preoperative EPA administration on postoperative adverse events such as postoperative atrial fibrillation (POAF) and postoperative infection in the cardiac surgery patients. The EPA administration significantly increased the serum EPA concentrations in both patient populations (p＜0.001). In the hyperlipidemic patients, the EPA administration significantly increased plasma adiponectin levels (p＜0.05), accompanied by a decrease in insulin resistance designated by the HOMA-IR (homeostasis model assessment of insulin resistance) score (p＜0.05) and Hs-CRP (high sensitivity C-reactive protein) value (p＜0.05). In the cardiac surgery patients, no significant effect of EPA on cardiac adverse events such as POAF was observed. However, our results clearly demonstrated that both the neutrophil-to-lymphocyte ratio and the 2nd-line antibiotic requirement in the EPA group were significantly decreased compared to the untreated control group (p＜0.05). We suggest that EPA administration may exert anti-inflammatory effects in patients with hyperlipidemia and in those undergoing cardiac surgery, possibly through an increase in plasma adiponectin levels. |
| キーワード | eicosapentaenoic acid adiponectin hyperlipidemic patients cardiac surgery atrial fibrillation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-12 |
| 巻 | 68巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 349 |
| 終了ページ | 361 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25519029 |
| Web of Science KeyUT | 000346882200005 |
| JaLCDOI | 10.18926/AMO/53023 |
|---|---|
| フルテキストURL | 68_6_339.pdf |
| 著者 | Nishie, Hiroyuki| Mizobuchi, Satoshi| Suzuki, Etsuji| Sato, Kenji| Toda, Yuichiro| Matsuoka, Junji| Morimatsu, Hiroshi| |
| 抄録 | The main purpose of this study was to determine the relationships between Japanese individualsʼ interest in living wills and their preferred end-of-life care and death locations. Questionnaires were mailed to 1,000 individuals aged ｧ50 to measure these 2 factors. We examined the associations between the respondentsʼ characteristics and their preferred care and death locations by using multinomial logistic regression models. The response rate was 74%. Home was the most frequently preferred place for end-of-life care (64%), and a palliative care unit (PCU) was the most commonly preferred place to die (51%). Living will interest was associated with a preference for care (odds ratio [OR] 4.74, 95% confidence interval [CI] 1.95-12.1) and death (OR 2.75, 95% CI 1.70-4.47) in a PCU rather than a hospital, but it was not associated with the choice between receiving care or dying at home instead of a hospital. We must consider why Japanese people think home death is impracticable. The Japanese palliative care system should be expanded to meet patientsʼ end-of-life needs, and this includes not only facilitating home care but also increasing access to PCU care. |
| キーワード | advance healthcare directive living will end-of-life care palliative care unit place of death |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-12 |
| 巻 | 68巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 339 |
| 終了ページ | 348 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25519028 |
| Web of Science KeyUT | 000346882200004 |
| JaLCDOI | 10.18926/AMO/53021 |
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| フルテキストURL | 68_6_323.pdf |
| 著者 | Hirayama, Takahiro| Nagano, Osamu| Shiba, Naoki| Yumoto, Tetsuya| Sato, Keiji| Terado, Michihisa| Ugawa, Toyomu| Ichiba, Shingo| Ujike, Yoshihito| |
| 抄録 | In adult high-frequency oscillatory ventilation (HFOV), stroke volume (SV) and mean lung pressure (PLung) are important for lung protection. We measured the airway pressure at the Y-piece and the lung pressure during HFOV using a lung model and HFOV ventilators for adults (R100 and 3100B). The lung model was made of a 20-liter, airtight rigid plastic container (adiabatic compliance: 19.3ml/cmH2O) with or without a resistor (20cmH2O/l/sec). The ventilator settings were as follows: mean airway pressure (MAP), 30cmH2O;frequency, 5-15Hz (every 1Hz);airway pressure amplitude (AMP), maximum;and % of inspiratory time (IT), 50% for R100, 33% or 50% for 3100B. The measurements were also performed with an AMP of 2/3 or 1/3 maximum at 5, 10 and 15Hz. The PLung and the measured MAP were not consistently identical to the setting MAP in either ventilator, and decreasing IT decreased the PLung in 3100B. In conclusion, we must pay attention to the possible discrepancy between the PLung and the setting MAP during adult HFOV. |
| キーワード | HFOV mean lung pressure mean airway pressure |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-12 |
| 巻 | 68巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 323 |
| 終了ページ | 329 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25519026 |
| Web of Science KeyUT | 000346882200002 |
| 著者 | Abe, N| Hou, D-X| Munemasa, S| Murata, Y| Nakamura, Y| |
|---|---|
| 発行日 | 2014-11-20 |
| 出版物タイトル | Cell Death and Disease |
| 巻 | 5巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Kobayashi, Tomoko| Suzuki, Etsuji| Oksanen, Tuula| Kawachi, Ichiro| Takao, Soshi| |
|---|---|
| 発行日 | 2014-01-31 |
| 出版物タイトル | PLoS ONE |
| 巻 | 9巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |