検索結果 3251 件
| JaLCDOI | 10.18926/AMO/53561 |
|---|---|
| フルテキストURL | 69_4_245.pdf |
| 著者 | Aoki, Kana| Sakuma, Mayumi| Ogisho, Noriyuki| Nakamura, Kozo| Chosa, Etsuo| Endo, Naoto| |
| 抄録 | Exercise is essential for maintaining quality of life (QOL) in elderly individuals. However, adherence to exercise programs is low. Here, we assessed the effectiveness of a self-directed home exercise program with serial telephone contacts to encourage exercise adherence among elderly individuals at high risk of locomotor dysfunction. We recruited community-dwelling adults (ｧ65 years) in Niigata, Japan, who were targets of the long-term care prevention project for locomotor dysfunction but did not participate in the government-sponsored prevention programs. The study was conducted from November 2011 to October 2012. Participants received exercise instruction and performed exercises independently for 3 months with serial telephone contacts. The single-leg stance and five-times sit-to-stand tests were used to assess physical function. The SF-8 was used to measure health-related QOL. Ninety-seven participants were enrolled in the study, representing 2.5ｵ of eligible people;87 completed the intervention. Scores from physical function tests were significantly improved by the intervention, as were 7 of eight SF-8 subscales. Adherence was 85.4ｵ for the single-leg standing exercise and 82.1ｵ for squatting. Thus, self-directed home exercise with serial telephone contacts improved physical function and health-related QOL, representing a promising model for preventing the need for long-term care due to locomotor dysfunction. |
| キーワード | locomotor dysfunction self-home exercise single-leg stance test five-times sit-to-stand test SF-8 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-08 |
| 巻 | 69巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 245 |
| 終了ページ | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 26289916 |
| Web of Science KeyUT | 000365519100008 |
| タイトル（別表記） | Proton therapy |
|---|---|
| フルテキストURL | 127_155.pdf |
| 著者 | 勝井 邦彰| 沖本 智昭| 金澤 右| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-08-03 |
| 巻 | 127巻 |
| 号 | 2号 |
| 開始ページ | 155 |
| 終了ページ | 157 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.127.155 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.155 |
| NAID | 130005096259 |
| タイトル（別表記） | An investigator initiated phase II clinical trial of tamibarotene (AM80G) for chronic graft-versus-host disease |
|---|---|
| フルテキストURL | 127_133.pdf |
| 著者 | 西森 久和| 前田 嘉信| |
| キーワード | 臨床研究中核病院 慢性GVHD タミバロテン 同種造血幹細胞移植 Th17 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-08-03 |
| 巻 | 127巻 |
| 号 | 2号 |
| 開始ページ | 133 |
| 終了ページ | 137 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.127.133 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.133 |
| NAID | 130005096255 |
| タイトル（別表記） | A prospective cohort study to define the clinical and pathological features of lung cancers harboring HER2 gene aberrations (the HER2-CS Study) and a phase II study of trastuzumab emtansine (recombinant) in patients with HER2-positive non-small cell lung cancer who recurred, progressed after standard chemotherapy, or were primarily refractory to standard chemotherapy |
|---|---|
| フルテキストURL | 127_127.pdf |
| 著者 | 木浦 勝行| 堀田 勝幸| 佐藤 晃子| 大橋 圭明| 二宮 崇| 南 大輔| 田端 雅弘| 久保 寿夫| 加藤 有加| 平田 泰三| |
| キーワード | 臨床研究中核病院 国立研究開発法人日本医療研究開発機構 文部科学省橋渡し研究加速ネットワークプログラム HER2-CS study trastuzumab emtansine |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-08-03 |
| 巻 | 127巻 |
| 号 | 2号 |
| 開始ページ | 127 |
| 終了ページ | 132 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.127.127 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.127 |
| NAID | 130005096256 |
| タイトル（別表記） | Successful laparoscopic resection of a cecal tumor in a 95-year-old man |
|---|---|
| フルテキストURL | 127_117.pdf |
| 著者 | 渡邉 彩子| 稲田 涼| 永坂 岳司| 八木 朝彦| 松本 聖| 戸嶋 俊明| 菊池 覚次| 黒田 新士| 近藤 喜太| 母里 淑子| 岸本 浩行| 藤原 俊義| |
| 抄録 | We report a successful laparoscopic resection of a cecal tumor in a 95-year-old Japanese man. The patient visited an initial hospital with a complaint of constipation in March 2014. Computed tomography scan and colonoscopy showed a stenotic ileocecal cancer with pericolic lymph node metastases, and he was referred to our department for management. Since his general condition was maintained, we performed a laparoscopic ileocecal resection with regional lymph node dissection for the patient. The operation achieved curative resection, and the tumor was diagnosed as a moderately differentiated adenocarcinoma and graded as pStage IIIa (pT3, pN0, pM0) according to the Japanese Classification of Colorectal Carcinoma, eighth edition. He was discharged on the 11th postoperative day without perioperative complications. Several large-scale randomized controlled trials （RCTs） revealed that laparoscopic surgeries for colorectal cancers have some advantages compared to open surgeries, including superior short-term outcomes and comparable long-term outcomes. Unfortunately, since these RCTs did not include enough elderly patients, the safety and feasibility of laparoscopic surgery for extremely elderly patients are still unknown. With respect to less-invasive procedures, these advantages of laparoscopic surgery are also thought to be the advantages for elderly colorectal cancer patients. |
| キーワード | 超高齢者（extremely elderly patient） 大腸癌（colorectal cancer） 腹腔鏡手術（laparoscopic surgery） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-08-03 |
| 巻 | 127巻 |
| 号 | 2号 |
| 開始ページ | 117 |
| 終了ページ | 121 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.127.117 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.117 |
| NAID | 130005096253 |
| タイトル（別表記） | Peritoneal dialysis update |
|---|---|
| フルテキストURL | 127_111.pdf |
| 著者 | 杉山 斉| |
| キーワード | 持続携行式腹膜透析（CAPD） 自動腹膜透析（APD） SMAP法 尿素Kt/V 腹膜平衡試験（peritoneal equilibration test:PET） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-08-03 |
| 巻 | 127巻 |
| 号 | 2号 |
| 開始ページ | 111 |
| 終了ページ | 115 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.127.111 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.111 |
| NAID | 130005096252 |
| タイトル（別表記） | Role of COLXV/XVⅢ gene, Multiplexin, as a basement membrane toolkit |
|---|---|
| フルテキストURL | 127_103.pdf |
| 著者 | 大橋 俊孝| |
| キーワード | 基底膜 ツールキット XV/XVⅢ型コラーゲン プロテオグリカン ミトコンドリア |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-08-03 |
| 巻 | 127巻 |
| 号 | 2号 |
| 開始ページ | 103 |
| 終了ページ | 109 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.127.103 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.103 |
| NAID | 130005096251 |
| JaLCDOI | 10.18926/AMO/53523 |
|---|---|
| フルテキストURL | 69_3_165.pdf |
| 著者 | Sarai, Takaaki| Tokumoto, Akihiro| |
| 抄録 | Fall accidents are a common cause of femoral fracture in the elderly. The greater trochanter of the femur is often subjected to impact loading by a sideways fall, and thus it is worth studying the impulsive stress waves propagating in the femur. In this study, the impulsive stress was analyzed by the dynamic finite element method using a 3-dimensional model of the femur, and the influence of the fall configuration on the stress was discussed. The stress was concentrated around the femoral neck during the propagation of the stress wave, and the tensile maximum principal stress changed into compressive minimum principle stress on the anterior and medial sides of the neck. On the other hand, the compressive minimum principal stress changed into tensile maximum principle stress on the lateral side of the neck. The largest maximum principal stress during the impact loading was always larger in the neck than in the impact region. The largest absolute value of the minimum principal stress was found in the neck or the impact region depending on the fall configuration. The largest absolute values of the maximum and minimum principal stress were nearly equal, indicating that the bone fracture due to the tensile stress may occur around the femoral neck. |
| キーワード | biomechanics sideways fall femoral neck greater trochanter impulsive stress wave |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-06 |
| 巻 | 69巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 165 |
| 終了ページ | 171 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 26101192 |
| Web of Science KeyUT | 000356903000005 |
| JaLCDOI | 10.18926/AMO/53520 |
|---|---|
| フルテキストURL | 69_3_137.pdf |
| 著者 | Seki, Hiroyuki| Ikeda, Fusao| Nanba, Shintaro| Moritou, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Nakamura, Minoru| Yamamoto, Kazuhide| |
| 抄録 | A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis. |
| キーワード | primary biliary cirrhosis keratin 7 hepatic failure |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-06 |
| 巻 | 69巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 137 |
| 終了ページ | 144 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 26101189 |
| Web of Science KeyUT | 000356903000002 |
| 著者 | 座間味 義人| 高取 真吾| 合田 光寛| 小山 敏広| 岩谷 有希子| Jin, Xin| Takada-Doi, Shima| 川﨑 博己| |
|---|---|
| 発行日 | 2008-11-01 |
| 出版物タイトル | Biological & Pharmaceutical Bulletin |
| 巻 | 31巻 |
| 号 | 11号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 座間味 義人| 高取 真吾| 小山 敏広| 合田 光寛| 岩谷 有希子| 土井 志真| 川﨑 博己| |
|---|---|
| 発行日 | 2007-12-01 |
| 出版物タイトル | 藥學雜誌 |
| 巻 | 127巻 |
| 号 | 12号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 座間味 義人| 藤原 弘喜| 細田 美穂| 日野 隼人| 平井 和浩| 岡本 和明| 金 鑫| 高取 真吾| 高木 志真| 川﨑 博己| |
|---|---|
| 発行日 | 2010-06-01 |
| 出版物タイトル | 藥學雜誌 |
| 巻 | 130巻 |
| 号 | 6号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 松山 誠| |
|---|---|
| 発行日 | 2015-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 31巻 |
| 資料タイプ | その他 |
| 著者 | 大森 斉| |
|---|---|
| 発行日 | 2015-04 |
| 出版物タイトル | 岡山実験動物研究会報 |
| 巻 | 31巻 |
| 資料タイプ | その他 |
| フルテキストURL | K0005116 abstract_review.pdf K0005116_fulltext.pdf K0005116_fulltext_other1.pdf |
|---|---|
| 著者 | 山中 俊明| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5116号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005114 abstract_review.pdf K0005114_fulltext.pdf |
|---|---|
| 著者 | 張 燃| |
| 発行日 | 2015-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5114号 |
| 学位授与年月日 | 2015-03-25 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| JaLCDOI | 10.18926/AMO/53338 |
|---|---|
| フルテキストURL | 69_2_95.pdf |
| 著者 | Lee, Mi Geum| Lee, Dong Kyu| Huh, Billy K.| Choi, Sang Sik| Kim, Hee Zoo| Lim, Byung Gun| Kim, Hong Soon| Choi, Yun Suk| Hur, Won Seok| Lee, Mi Kyoung| |
| 抄録 | Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. Using a rat model of neuropathic pain, we evaluated the effect of pretreatment with clonidine－which has been shown to relieve intradermal capsaicin-induced hyperalgesia－on the initial hyperalgesic response and the thermal analgesic property of RTX. Thirty-six male rats were divided into 6 treatment groups (n＝6 each):RTX 500ng, RTX 1μg, clonidine 20μg (Cl), Cl＋RTX 500ng, Cl＋RTX 1μg, or normal saline 20μL (control). We evaluated the short-term (180min) and long-term (20 days) analgesic effects of RTX after thermal stimulation and mechanical stimulation. RTX had significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to the thermal stimulus, but the RTX 500ng and RTX 1μg groups showed no initial short-term thermal hyperalgesic responses when pretreated with clonidine. The Cl＋RTX 1μg ratsʼ behavior scores indicated that they were more calm and comfortable compared to the RTX 1μg rats. Even though we cannot precisely confirm that pretreatment with clonidine potentiates or adds to the analgesic effect of RTX, clonidine pretreatment with epidural RTX eliminated the initial RTX-associated hyperalgesic response and systemic toxicity in this neuropathic pain rat model. |
| キーワード | clonidine epidural administration resiniferatoxin spinal nerve ligation rat model thermal hyperalgesia |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-04 |
| 巻 | 69巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 95 |
| 終了ページ | 103 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25899631 |
| Web of Science KeyUT | 000353181700004 |
| JaLCDOI | 10.18926/53314 |
|---|---|
| タイトル（別表記） | Preliminary Trials of Medical Safety Education regarding the Occurrence and Prevention of Human Error based on the Swiss Cheese Model |
| フルテキストURL | hss_039_119_135.pdf |
| 著者 | 山本 恵美子| 田中 共子| 兵藤 好美| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2015-03-26 |
| 巻 | 39巻 |
| 開始ページ | 119 |
| 終了ページ | 135 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2015 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 120005593531 |
| フルテキストURL | hara_CASPer15_final_rev2.pdf |
|---|---|
| 著者 | Hara, Sunao| Abe, Masanobu| Sonehara, Noboru| |
| 備考 | © © 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The article has been accepted for publication. Published in:Pervasive Computing and Communication Workshops (PerCom Workshops), 2015 IEEE International Conference on; Date of Conference:23-27 March 2015; Page(s):390 - 395; Conference Location : St. Louis, MO, USA; Publisher:IEEE; Publisher URL:http://dx.doi.org/10.1109/PERCOMW.2015.7134069 ; © Copyright 2015 IEEE - All rights reserved.| |
| 発行日 | 2015-03 |
| 出版物タイトル | Proceedings of 2015 IEEE International Conference on Pervasive Computing and Communication Workshops (PerCom Workshops) |
| 出版者 | IEEE |
| 開始ページ | 390 |
| 終了ページ | 395 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1109/PERCOMW.2015.7134069 |
| 著者 | 牧原 靖一郎| 岡野 光博| |
|---|---|
| 発行日 | 2015-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 127巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |