検索結果 1455 件
| JaLCDOI | 10.18926/AMO/65739 |
|---|---|
| フルテキストURL | 77_4_341.pdf |
| 著者 | Otsuka, Motoyuki| |
| 抄録 | Hepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral replication and hepatocarcinogenesis mechanisms are described, with a focus on the recently reported viral replication mechanisms related to degradation of the Smc5/6 protein complex. We also discuss our recent discovery of a compound that inhibits HBx protein-induced degradation of the Smc5/6 protein complex, and that exerts inhibitory effects on both viral replication and hepatocarcinogenesis. Finally, prospects for future research on the HBx protein are described. |
| キーワード | HBx Smc5/6 DDB1 nitazoxianide DNA repair |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-08 |
| 巻 | 77巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 341 |
| 終了ページ | 345 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37635133 |
| Web of Science KeyUT | 001163659800007 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hirai, Ryosuke| Kawano, Seiji| Inoo, Shoko| Kuraoka, Sakiko| Okanoue, Shotaro| Satomi, Takuya| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawahara, Yoshiro| Okada, Hiroyuki| |
| キーワード | Fibrinolytic agents Endoscopic submucosal resection Postoperative hemorrhage Purinergic P2Y receptor antagonists |
| 発行日 | 2022-09-29 |
| 出版物タイトル | Gut and Liver |
| 巻 | 17巻 |
| 号 | 3号 |
| 出版者 | The Editorial Office of Gut and Liver |
| 開始ページ | 404 |
| 終了ページ | 411 |
| ISSN | 1976-2283 |
| NCID | AA12329814 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Gut and Liver. |
| 論文のバージョン | publisher |
| PubMed ID | 36172713 |
| DOI | 10.5009/gnl220196 |
| Web of Science KeyUT | 000869939200001 |
| 関連URL | isVersionOf https://doi.org/10.5009/gnl220196 |
| フルテキストURL | fulltext20230706-01.pdf fig1_20230706-01.pdf fig2_20230706-01.pdf suppl20230706-01.pdf |
|---|---|
| 著者 | Kondo, Takumi| Fujii, Keiko| Fujii, Nobuharu| Sumii, Yuichi| Urata, Tomohiro| Kimura, Maiko| Matsuda, Masayuki| Ikegawa, Shuntaro| Washio, Kana| Fujiwara, Hideaki| Asada, Noboru| Ennishi, Daisuke| Nishimori, Hisakazu| Matsuoka, Ken‐ichi| Otsuka, Fumio| Maeda, Yoshinobu| |
| キーワード | blood center operations cellular therapy therapeutic apheresis |
| 備考 | This is the peer reviewed version of the following article: [Kondo T, Fujii K, Fujii N, Sumii Y, Urata T, Kimura M, et al. Efficient granulocyte collection method using high concentrations of medium molecular weight hydroxyethyl starch. Transfusion. 2023; 63(7): 1344–1353. https://doi.org/10.1111/trf.17450], which has been published in final form at [https://doi.org/10.1111/trf.17450]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Jun. 2024.| |
| 発行日 | 2023-06-09 |
| 出版物タイトル | Transfusion |
| 巻 | 63巻 |
| 号 | 7号 |
| 出版者 | Wiley |
| 開始ページ | 1344 |
| 終了ページ | 1353 |
| ISSN | 0041-1132 |
| NCID | AA00868753 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 AABB. |
| 論文のバージョン | author |
| PubMed ID | 37293978 |
| DOI | 10.1111/trf.17450 |
| Web of Science KeyUT | 001004560100001 |
| 関連URL | isVersionOf https://doi.org/10.1111/trf.17450 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Muzembo, Basilua Andre| Kitahara, Kei| Mitra, Debmalya| Ohno, Ayumu| Khatiwada, Januka| Dutta, Shanta| Miyoshi, Shin-Ichi| |
| キーワード | Shigella vaccine Shigella sonnei Shigella flexneri Diarrhea Dysentery Shiga toxin Travel |
| 発行日 | 2023-04 |
| 出版物タイトル | Travel Medicine and Infectious Disease |
| 巻 | 52巻 |
| 出版者 | Elsevier |
| 開始ページ | 102554 |
| ISSN | 1477-8939 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36792021 |
| DOI | 10.1016/j.tmaid.2023.102554 |
| Web of Science KeyUT | 000944007500001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.tmaid.2023.102554 |
| JaLCDOI | 10.18926/AMO/65504 |
|---|---|
| フルテキストURL | 77_3_335.pdf |
| 著者 | Fujii, Kentaro| Hirano, Shuichiro| Kurozumi, Kazuhiko| Date, Isao| |
| 抄録 | An 85-year-old woman presented with aphasia due to an occupying lesion in the left frontal lobe near the language area. Complete resection of the contrast-enhancing lesion was performed under awake conditions. The pathological diagnosis was anaplastic astrocytoma, and postoperative radiochemotherapy was administered. Awake surgery is a useful technique to reduce postoperative neurological sequelae and to maximize surgical resection. Although the patient was elderly, which is generally considered high risk, she did not have any severe neurological deficits and had a good outcome. Even in the extreme elderly, awake surgery can be useful for gliomas in language cortices. |
| キーワード | awake surgery high-grade glioma eloquent area elderly patient |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-06 |
| 巻 | 77巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 335 |
| 終了ページ | 340 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37357636 |
| Web of Science KeyUT | 001026663400002 |
| JaLCDOI | 10.18926/AMO/65497 |
|---|---|
| フルテキストURL | 77_3_319.pdf |
| 著者 | Kashihara, Kenichi| |
| 抄録 | I report a case of arterial spine-labelled MR imaging (ASL)-detected cerebral hypoperfusion during migraine and panic attacks. A 20-year-old woman with a history of headache for 6 years and independent panic attacks for 3 years was transferred to Okayama Kyokuto Hospital for panic attacks. On that day, she had had severe headache that was improved by taking non-steroidal anti-inflammatory drug, but panic attacks initiated. On arrival, she also complained of a mild headache. ASL revealed cerebral hypoperfusion in the right temporo-occipital region. The threshold to induce panic attacks in migraine patients could be lowered by the physiopathology underlying migraine attacks. |
| キーワード | migraine panic attack arterial spine-labelled magnetic resonance imaging aura cortical spreading depression |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-06 |
| 巻 | 77巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 319 |
| 終了ページ | 321 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37357633 |
| Web of Science KeyUT | 001026279600010 |
| JaLCDOI | 10.18926/AMO/65496 |
|---|---|
| フルテキストURL | 77_3_311.pdf |
| 著者 | Miura, Takanori| Kijima, Hiroaki| Tazawa, Hiroshi| Miyakoshi, Naohisa| |
| 抄録 | Japan’s hip fracture management guidelines now recommend the use of cemented stems in cases of bone fragility. However, the current stem selection practices in bipolar hemiarthroplasty (BHA) in a super-aging area in Japan remain unclear. This study aimed to examine the stem selection policies, the surgeons’ concerns about cemented stems, and factors affecting their confidence in their ability to coach others on cemented stem procedures. Ninety-four orthopedic surgeons (27 facilities) responded to our web-based questionnaire conducted in January/February 2022. Cementless stem was the first choice of 97.8% of the surgeons; <15% of the respondents expected to increase their use of cemented stems in the future. The cement technique was the greatest concern; almost half of the surgeons described having insufficient experience with cemented stems. The factor that most affected the surgeons’ expertise in using cemented stems is the number of surgeries they had conducted with a cemented stem (multivariable analysis odds ratio 8.42, p=0.001). Greater experience was associated with increased expertise of the surgeons in using cemented stems, with a threshold of 11 cases showing sensitivity of 41.7% and specificity of 98.3% for their confidence to instruct cemented stems. |
| キーワード | hip fracture arthroplasty bone cement questionnaire |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-06 |
| 巻 | 77巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 311 |
| 終了ページ | 318 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37357632 |
| Web of Science KeyUT | 001026279600009 |
| JaLCDOI | 10.18926/AMO/65494 |
|---|---|
| フルテキストURL | 77_3_291.pdf |
| 著者 | Himei, Hitomi| Kato, Hironari| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| 抄録 | We investigated the efficacy and safety of endoscopic plastic stent (PS) placement for hilar benign biliary strictures (BBSs) and compared cases with PS placement above (inside stent, IS) and across (usual stent, US) the sphincter of Oddi. Patients who underwent initial endoscopic PS placement for hilar BBSs between August 2012 and December 2021 were retrospectively analyzed. Hilar BBSs in 88 patients were investigated. Clinical success was achieved in 81 of these cases (92.0%), including 38 patients in the IS group and 43 patients in the US group. Unexpected stent exchange (uSE) before the first scheduled PS exchange occurred in 18 cases (22.2%). The median time from first stent placement to uSE was 35 days. There was no significant difference in the rate and median time to uSE between the two groups. The rates of adverse events such as pancreatitis or cholangitis in the two groups did not significantly differ. However, the rate of difficult stent removal in the IS group (15.8%) was significantly higher than that in the US group (0%) (p=0.0019). US placement is preferable to IS placement for scheduled stent exchange, as it offers the same effectiveness and risk of adverse events with easier stent removal. |
| キーワード | benign biliary stricture inside stent plastic stent |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-06 |
| 巻 | 77巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 291 |
| 終了ページ | 299 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37357630 |
| Web of Science KeyUT | 001026279600007 |
| JaLCDOI | 10.18926/AMO/65493 |
|---|---|
| フルテキストURL | 77_3_281.pdf |
| 著者 | Mukai, Yuko| Taira, Naruto| Kajiwara, Yukiko| Iwamoto, Takayuki| Kitaguchi, Yohei| Saiga, Miho| Watanabe, Satoko| Shien, Tadahiko| Doihara, Hiroyoshi| Kimata, Yoshihiro| |
| 抄録 | Although immediate breast reconstruction following mastectomy has become increasingly common, its oncological safety has been debated. We enrolled patients with breast cancer who underwent surgery at Okayama University Hospital between 2007 and 2013. The primary outcome was relapse-free survival (RFS). Secondary outcomes were overall survival and the duration from the surgery to the initiation of adjuvant chemotherapy. We divided into immediate breast reconstruction, mastectomy alone, and breast conservative surgery groups. Outcomes were compared using Cox’s regression analysis. A total of 614 patients were included (reconstruction: 125, mastectomy: 128, breast conservative surgery: 361). The median follow-up duration was 79.0±31.9 months. The immediate-reconstruction patients were younger, had more lymph node metastases, and more often received postoperative chemotherapy. The RFS was better after the breast conservative surgery compared to after reconstruction (hazard ratio 0.33, 95% confidence interval: 0.144-0.763). The proportion of local recurrence was highest in the reconstruction group. No patients in the reconstruction group underwent postoperative radiation therapy. However, reconstruction did not affect overall survival or the time to the initiation of adjuvant chemotherapy. Surgeons should explain the risks of breast reconstruction to their patients preoperatively. Careful long-term follow-up is required after such procedures. |
| キーワード | immediate breast reconstruction oncological safety local recurrence postoperative radiation therapy time to initiation of adjuvant chemotherapy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-06 |
| 巻 | 77巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 281 |
| 終了ページ | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37357629 |
| Web of Science KeyUT | 001026279600006 |
| JaLCDOI | 10.18926/AMO/65491 |
|---|---|
| フルテキストURL | 77_3_263.pdf |
| 著者 | Guo, Yusheng| Kosaka, Junko| Morimatsu, Hiroshi| |
| 抄録 | Continuous renal replacement therapy (CRRT) is widely used to control fluid balance, but the optimal fluid balance to improve the prognosis of patients remains debated. Appropriate fluid management may depend on hemodynamic status. We investigated the association between 90-day mortality and fluid balance/mean arterial pressure (MAP) in patients receiving CRRT. This single-center retrospective study was conducted between May 2018 and March 2021. Based on the cumulative fluid balance at 72 h after initiation of CRRT, the cases were divided into negative (< 0 mL) and positive (> 0 mL) fluid balance groups. Ninety-day mortality was higher in the positive fluid balance group (p=0.009). At 4 h before and after CRRT initiation, the mean MAP was lower in the positive fluid balance group (p<0.05). After multivariate cox adjustment, 72-h positive fluid balance was independently associated with 90-day mortality (p=0.004). In addition, the cumulative fluid balance was associated with 90-day mortality (p<0.05) in cases without shock, high APACHE II score, sepsis, dialysis dependence, or vasopressor use. A 72-h positive fluid balance was associated with 90-day mortality in patients receiving CRRT. |
| キーワード | fluid management continuous renal replacement therapy mortality mean arterial pressure daily cumulative fluid balance |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-06 |
| 巻 | 77巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 263 |
| 終了ページ | 272 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37357627 |
| Web of Science KeyUT | 001026279600004 |
| JaLCDOI | 10.18926/AMO/65490 |
|---|---|
| フルテキストURL | 77_3_255.pdf |
| 著者 | Fukushima, Shinnosuke| Hagiya, Hideharu| Uda, Kazuhiro| Gotoh, Kazuyoshi| Otsuka, Fumio| |
| 抄録 | Antimicrobial resistance is an emerging global threat that must be addressed using a multidisciplinary approach. This study aimed to raise awareness of high-level antimicrobial-resistant (AMR) pathogens in Japan by comparing their recent prevalences among prefectures, particularly Okayama. Data for the isolation proportions of meropenem-resistant Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, cefotaxime-resistant Escherichia coli and Klebsiella pneumoniae, and levofloxacin-resistant E. coli and K. pneumoniae were collected from the Japan Nosocomial Infections Surveillance, a national database sponsored by the Japanese Ministry of Health, Labour, and Welfare, between 2018 and 2021. The average isolated proportions of the seven AMR pathogens were higher in Okayama compared to other prefectures: the worst (19.9%) was meropenem-resistant P. aeruginosa, the sixth worst (57.2%) was methicillin-resistant S. aureus, the eighth worst (3.3%) was vancomycin-resistant E. faecium, the second (37.8%) and fifth worst (17.6%) were cefotaxime-resistant E. coli and K. pneumoniae, respectively, and the fourth (49.9%) and third worst (8.7%) were levofloxacin-resistant E. coli and K. pneumoniae, respectively. Our study highlights the notably high prevalences of representative AMR pathogens in Okayama, suggesting the need for fundamental infection prevention and control by healthcare professionals, promoting antimicrobial stewardship, and educating undergraduates and postgraduates in Okayama. |
| キーワード | antimicrobial resistance antimicrobial stewardship epidemiology infection prevention and control Japan Nosocomial Infections Surveillance |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-06 |
| 巻 | 77巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 255 |
| 終了ページ | 262 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37357626 |
| Web of Science KeyUT | 001026279600003 |
| JaLCDOI | 10.18926/AMO/65489 |
|---|---|
| フルテキストURL | 77_3_243.pdf |
| 著者 | Shibata, Yusuke| Eguchi, Jun| Wada, Jun| |
| 抄録 | Brown adipose tissue (BAT) plays a critical role in metabolic homeostasis. BAT dysfunction is associated with the development of obesity through an imbalance between energy expenditure and energy intake. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis. However, the roles of PPARγ and thiazolidinediones (TZDs) in the regulation of BAT metabolism remain unclear. TZDs, which are selective PPARγ activators, improve systemic insulin resistance in animals and humans. In the present study, we generated brown adipocyte-specific PPARγ-deficient mice (BATγKO) to examine the in vivo roles of PPARγ and TZDs in BAT metabolism. In electron microscopic examinations, brown adipocyte-specific PPARγ deletion promoted severe whitening of brown fat and morphological alteration of mitochondria. Brown adipocyte-specific PPARγ deletion also reduced mRNA expression of BAT-selective genes. Although there was no difference in energy expenditure between control and BATγKO mice in calorimetry, norepinephrine-induced thermogenesis was impaired in BATγKO mice. Moreover, pioglitazone treatment improved diet-induced insulin resistance in the control mice but not in the BATγKO mice. These findings suggest that BAT PPARγ is necessary for the maintenance of brown adipocyte function and for the insulin-sensitizing action of TZDs. |
| キーワード | PPARγ brown adipose tissue thiazolidinediones |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-06 |
| 巻 | 77巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 243 |
| 終了ページ | 254 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37357625 |
| Web of Science KeyUT | 001026279600002 |
| フルテキストURL | K0006802_abstract_review.pdf K0006802_fulltext.pdf K0006802_summary.pdf |
|---|---|
| 著者 | 松木 宣嘉 | |
| 発行日 | 2023-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6802号 |
| 学位授与年月日 | 2023-03-24 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| JaLCDOI | 10.18926/AMO/65154 |
|---|---|
| フルテキストURL | 77_2_221.pdf |
| 著者 | Iriyoshi, Hiroki| Sada, Ken-ei| Miyauchi, Atsushi| Yamamoto, Hirotaka| Hashimoto, Daisuke| Nojima, Shigeru| Yamanaka, Shingo| Kawamura, Masafumi| Oka, Satoshi| |
| 抄録 | Several previous case reports have shown that patients with immunoglobulin D (IgD) multiple myeloma (MM) can be withdrawn from hemodialysis, however, the characteristics that can predict withdrawal in these patients have not yet been elucidated. A 57-year-old Japanese woman required hemodialysis because of renal dysfunction due to IgD-λ and Bence Jones protein-λ MM. Bortezomib-based chemotherapy nine days after admission led to her withdrawal from hemodialysis on Day 50. In our case-based review, younger age and early initiation of bortezomib-based chemotherapy emerged as possible predictors of successful hemodialysis withdrawal. |
| キーワード | IgD-type multiple myeloma acute renal dysfunction urinary protein hemodialysis bortezomib |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 221 |
| 終了ページ | 225 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094962 |
| Web of Science KeyUT | 000982563800005 |
| JaLCDOI | 10.18926/AMO/65148 |
|---|---|
| フルテキストURL | 77_2_185.pdf |
| 著者 | Sugihara, Akiko| Okada, Ayumi| Horiuchi, Makiko| Yabe, Mayumi| Shigeyasu, Yoshie| Fujii, Chikako| Tanaka, Chie| Yorifuji, Takashi| Tsukahara, Hirokazu| |
| 抄録 | Psychosomatic disorders are influenced by psychosocial factors such as interpersonal relationships. Coping behaviors, especially in frustrating situations, reflect a patient’s ability to cope with stress, and it is important to assess these behaviors for the treatment of psychosomatic diseases. This study aimed to clarify the interpersonal relationships and coping behaviors of pediatric patients with psychosomatic diseases during frustrating situations simulated using the Rosenzweig Picture-Frustration study. This retrospective study included 126 patients (41 male, 85 female) with an average age of 12.9 (6-16) years who were consulted at the Department of Pediatric Psychosomatic Medicine at Okayama University Hospital from 2013 to 2018 and underwent the P-F study. Each score was compared with a standardization sample. The mean group conformity rating did not differ significantly between the participants and healthy children. Compared with healthy children, those with psychosomatic diseases were less likely to explain their perspective. The children with psychosomatic disorders responded to frustrating situations in a sensible and age-appropriate manner. However, they were less likely to respond by explaining their perspective to protect themselves. |
| キーワード | psychosomatic disorder picture-frustration study children projective technique group conformity rating |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 185 |
| 終了ページ | 192 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094956 |
| Web of Science KeyUT | 000982503800008 |
| JaLCDOI | 10.18926/AMO/65146 |
|---|---|
| フルテキストURL | 77_2_169.pdf |
| 著者 | Inoue, Kanae| Fujita, Rio| Nagahara, Takatoshi| Murakami, Shiho| Nagai, Yuta| Moriwake, Rina| Miyake, Nozomi| Wakuta, Akiko| Kariyama, Kazuya| Nishimura, Mamoru| Nouso, Kazuhiro| |
| 抄録 | Alcoholic liver disease is a risk factor for non-virus-related hepatocellular carcinoma (HCC), which is increasing in prevalence. This study aimed to identify the factors for recovery from alcoholic liver failure. Sixty-two consecutive patients hospitalized for alcoholic liver failure at Okayama City Hospital were enrolled. The characteristics of patients who survived to the 1-month follow-up and whose liver function improved to Child–Pugh A at 3 months (CPA3) and 12 months (CPA12) were compared with the rest of the patients. The survivors at 1 month (50 patients) were significantly younger than the deceased patients and had better liver and renal function with higher levels of γ-glutamyl transferase (GGT). The same factors, except renal function, were correlated with achieving CPA3. High AST, ALT, and GGT levels as well as short spleen length, total abstinence, and good Child–Pugh scores at admission were identified as factors for achieving CPA12. The extent of alcohol intake before admission was not identified as a risk factor in any analysis. In conclusion, baseline liver function is crucial for survival and achieving CPA3, whereas high transaminase and γ-GTP levels, the absence of splenomegaly, and total abstinence are significant factors for achieving CPA12. |
| キーワード | alcoholic liver failure risk factors recovery |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 169 |
| 終了ページ | 177 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094954 |
| Web of Science KeyUT | 000982503800006 |
| JaLCDOI | 10.18926/AMO/65145 |
|---|---|
| フルテキストURL | 77_2_161.pdf |
| 著者 | Yamanoi, Tomoko| Suzuki, Satoshi| Kaku, Ryuji| Morimatsu, Hiroshi| |
| 抄録 | An intraoperative double-low condition is defined as concurrent low values for bispectral index (BIS) and mean arterial pressure (MAP), and may predict perioperative outcomes. We hypothesized that prolonged double-low times might be associated with an increased incidence of postoperative delirium. We conducted a single-center retrospective observational study on patients who had been admitted to our hospital’s intensive care unit (ICU) after surgery and whose BIS and MAP data had been recorded during general anesthesia. The primary outcome was the incidence of postoperative delirium. A double-low condition was defined as BIS < 45 and MAP <75 mmHg. The total double-low time was calculated in 1-min increments and used to divide the patients into quintiles. Multiple logistic regression analyses were conducted. Among the 334 patients included in the study, the incidence of postoperative delirium was 15.6% (n=52). Multiple logistic regression analysis revealed that a prolonged double-low time, defined as a total double-low time of > 42 min (i.e., third, fourth, and fifth quintiles), was significantly associated with an increased incidence of postoperative delirium (adjusted odds ratio: 2.61, 95% confidence interval: 1.27-5.37, p=0.009). Prolonged double-low time during general anesthesia was independently associated with an increased incidence of postoperative delirium in surgical ICU patients. |
| キーワード | postoperative delirium bispectral index hypotension double-low condition general anesthesia |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 161 |
| 終了ページ | 167 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094953 |
| Web of Science KeyUT | 000982503800005 |
| JaLCDOI | 10.18926/AMO/65144 |
|---|---|
| フルテキストURL | 77_2_147.pdf |
| 著者 | Arias, Zulema| Haines, Stephanie| Yamamoto, Tadashi| Hatanaka, Kazu| Yamashiro, Keisuke| Sonoi, Norihiro| Takashiba, Shogo| |
| 抄録 | The curriculum at the Department of Pathophysiology in the Periodontal Sciences program at Okayama University includes normative preclinical training (NPT) using phantoms. NPT is given to the whole class of 5 th year students divided in groups of 8 students/instructor. In 2019, an innovative personalized preclinical training (PPT) pilot study was implemented for this group of students whereby two students, each with their own dental unit, were coached by one instructor. The main topics covered were dental ergonomics and endodontics. We aimed to evaluate the effectiveness of PPT in dental ergonomics and endodontics toward increasing the knowledge and future clinical skills of students who had already undergone NPT. A test on endodontics was taken before and after PPT. A questionnaire was completed to assess their perception of improvement regarding the above-mentioned topics. Test scores and questionnaire results both showed that the students’ level of knowledge and awareness of future clinical skills was significantly higher after PPT. This pilot study demonstrated that PPT increased the students’ knowledge and future clinical skills. As preclinical training forms the foundation for clinical practice, investment in future research regarding this personalized approach is likely to enhance students’ understanding and clinical performance. |
| キーワード | preclinical personalized education dental ergonomics endodontics clinical skills improvement undergraduate students |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 147 |
| 終了ページ | 159 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094952 |
| Web of Science KeyUT | 000982503800004 |
| JaLCDOI | 10.18926/AMO/65143 |
|---|---|
| フルテキストURL | 77_2_139.pdf |
| 著者 | Namio, Keiichi| Kondo, Takashi| Miyatake, Nobuyuki| Hishii, Shuhei| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Suzuki, Hiromi| Koumoto, Kiichi| |
| 抄録 | We investigated the link between prolonged sedentary bouts and all-cause mortality in patients on chronic hemodialysis, using a prospective cohort. A total of 104 outpatients on chronic hemodialysis from 2013 to 2019, aged 71.4±11.4 years, were enrolled. Prolonged sedentary bouts (≥ 30 min and ≥60 min) (min and bouts) and relative prolonged sedentary bouts (≥ 30 min and ≥ 60 min) (%) on the patients’ non-hemodialysis days were measured by a tri-accelerometer, and we also analyzed the patients’ clinical parameters. The relationship between prolonged sedentary bouts and all-cause mortality was evaluated by a survival analysis and the Cox proportional hazard model. Thirty-five patients died during the follow-up period. A Kaplan-Meier analysis detected significant differences in the survival rate between two groups stratified by the median for all prolonged sedentary-bout parameters. After the adjustment for confounding factors, all of the prolonged sedentary-bout parameters were determinant factors for all-cause mortality. These results indicate that prolonged sedentary bouts on non-hemodialysis days were closely related to all-cause mortality in the patients on hemodialysis. |
| キーワード | sedentary bout mortality hemodialysis survival analysis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 139 |
| 終了ページ | 145 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094951 |
| Web of Science KeyUT | 000982503800003 |
| JaLCDOI | 10.18926/AMO/65142 |
|---|---|
| フルテキストURL | 77_2_131.pdf |
| 著者 | Senda, Mayuko| Terada, Seishi| Fujiwara, Masaki| Yamada, Norihito| |
| 抄録 | Eating disorders (EDs) are associated with a high mortality rate. Patients with EDs often experience severe dehydration due to food restriction and/or vomiting. Severely underweight patients are often prescribed bed rest during inpatient care to reduce their energy consumption, and they may thus develop multiple risk factors for venous thromboembolism (VTE). We compared the clinical features of ED inpatients with VTE to those of ED inpatients without VTE. Seventy-one inpatients with ED were treated at Okayama University Hospital’s psychiatric ward in 2016-2020; five were experienced a VTE. Compared to the non-VTE group, the VTE group’s median age and disease duration were greater and the median body mass index (BMI) was lower. The VTE group’s D-dimer peak values were > 5 mg/L. Physical restraint and central venous catheter use were associated with VTE. Longer ED duration and lower BMI might be risk factors for VTE. To make inpatient treatment for ED safer, it is important to avoid the use of physical restraints and central venous catheters. Continuous D-dimer monitoring is necessary for the early detection of VTE in ED patients at high risk of VTE. |
| キーワード | eating disorder anorexia nervosa venous thromboembolism deep vein thrombosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 131 |
| 終了ページ | 137 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094950 |
| Web of Science KeyUT | 000982503800002 |