検索結果 1505 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamamoto, Hiroshi| Hanaya, Tadashi| Harada, Koichiro| Kawamoto, Heizan| Pfleiderer, Wolfgang| |
| 発行日 | 2013-03-01 |
| 出版物タイトル | Pteridines |
| 巻 | 7巻 |
| 号 | 3号 |
| 出版者 | Walter de Gruyter GmbH |
| 開始ページ | 110 |
| 終了ページ | 112 |
| ISSN | 2195-4720 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2013 by Walter de Gruyter GmbH & Co. |
| 論文のバージョン | publisher |
| DOI | 10.1515/pteridines.1996.7.3.110 |
| 関連URL | isVersionOf https://doi.org/10.1515/pteridines.1996.7.3.110 |
| JaLCDOI | 10.18926/AMO/71071 |
|---|---|
| フルテキストURL | 80_4_265.pdf |
| 著者 | Yamasaki, Takuto| Sugaya, Akiko| Naoi, Yuto| Kariya, Shin| Ando, Mizuo| |
| 抄録 | Cochlear implantation (CI) in patients with CHARGE syndrome presents unique surgical challenges due to complex external, middle, and inner ear malformations. We describe the case of a 3-year-old Japanese boy for whom simultaneous transcanal CI under endoscopic guidance and external auditory canal closure were performed. This approach enabled safe electrode placement and resulted in favorable auditory outcomes, representing a potential novel surgical option for CI in patients with CHARGE syndrome. There are few reports of this type of surgical intervention, and the present case highlights the feasibility and clinical benefits of individualized surgical planning for CI in anatomically complex patients. |
| キーワード | CHARGE syndrome cochlear implantation transcanal approach temporal bone anomaly pediatric otologic surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 265 |
| 終了ページ | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Yoon PJ: Pediatric cochlear implantation. Curr Opin Pediatr (2011) 23: 346-350.| Carlson ML: Cochlear Implantation in Adults. N Engl J Med (2020) 382: 1531-1542.| Mori N: Current trends of cochlear implant in Japan. JAHS (2015) 6: 15-23.| Blake KD, Davenport SL, Hall BD, Hefner MA, Pagon RA, Williams MS, Lin AE and Graham JM Jr: CHARGE association: an update and review for the primary pediatrician. Clin Pediatr (Phila) (1998) 37: 159-173.| Morimoto AK, Wiggins RH, Hudgins PA, Hedlund GL, Hamilton B, Mukherji SK, Telian SA and Harnsberger HR: Absent Semicircular Canals in CHARGE Syndrome: Radiologic Spectrum of Findings. AJNR Am J Neuroradiol (2006) 27: 1663-1671.| Vincenti V, Di Lella F, Falcioni M, Negri M and Zanetti D: Cochlear implantation in children with CHARGE syndrome: a report of eight cases. Eur Arch Otorhinolaryngol (2018) 275: 1987-1993.| Hsieh CY, Sun CH, Lin WL, Gotamco GL, Hsu CJ and Wu HP: Modified Transcanal Cochlear Implantation in CHARGE Syndrome: A Case Report. Medicine (Baltimore) (2019) 98: e18283.| Wick CC, Moore AM, Killeen DE and Isaacson B: The Modified Rambo Transcanal Approach for Cochlear Implantation in CHARGE Syndrome. Otol Neurotol (2017) 38: 1268-1272.| Marchioni D, Carner, M, Soloperto D, Sacchetto, A, Genovese E and Presutti L: Endoscopic-assisted Cochlear Implant Procedure in CHARGE Syndrome: Preliminary Report. Acta Oto-Laryngologica Case Reports (2017) 2: 52-58.| Pamuk E, Eroğlu E and Sennaroğlu L: Pediatric cochlear implantation in otitis media with effusion: Are ventilation tubes truly necessary? Int J pediatr Otorhinolaryngol (2025) 188: 112203.| Said NM, Telmesani LS and Telmesani LM: Effect of congenital inner ear malformations (IEMs) on electrically evoked compound action potential (ECAP) responses in cochlear implant children. Eur Arch Otorhinolaryngol (2023) 280: 5193-5204.| Zizlavsky S, Saleh RR and Priyono H: Intraoperative Electrically Evoked Auditory Brainstem Response (eABR) examination in cochlear implant candidacy. Oto Rhino Laryngologica Indonesiana (2024) 54: 80-86.| Nada N, Kolkaila E, Schendzielorz P and El Mahallawi T: Electrically evoked auditory brainstem response in cochlear implantation: what you need to know. Egyptian Journal of Otolaryngology (2022) 38: 67.| Rajput K, Brown T and Bamiou DE: Aetiology of hearing loss and other related factors versus language outcome after cochlear implantation in children. Int J Pediatr Otorhinolaryngol (2003) 67: 497-504.| Nishio SY, Moteki H, Miyagawa M, Yamasoba T, Kashio A, Iwasaki S, Takahashi M, Naito Y, Fujiwara K, Sugaya A, Takahashi H, Kitaoka K and Usami SI: Etiology of hearing loss affects auditory skill development and vocabulary development in pediatric cochlear implantation cases. Acta Otolaryngol (2022) 142: 308-315.| Birman CS, Elliott EJ and Gibson WP: Pediatric cochlear implants: Additional disabilities prevalence, risk factors, and effect on language outcomes. Otol Neurotol (2012) 33: 1347-1352.| Lanson BG, Green JE, Roland JT Jr, Lalwani AK and Waltzman SB: Cochlear implantation in children with CHARGE syndrome: surgical considerations and outcomes. Otol Neurotol (2007) 17: 1260-1266.| Blake KD and Prasad C: CHARGE syndrome. Orphanet J Rare Dis (2018) 7; 1: 34.| Ahn JH and Lee KS: Outcomes of cochlear implantation in CHARGE syndrome. Acta Otolaryngol (2013) 133: 1148-1153.| |
| JaLCDOI | 10.18926/AMO/71070 |
|---|---|
| フルテキストURL | 80_4_259.pdf |
| 著者 | Yabuno, Satoru| Yunoki, Masatoshi| Takeuchi, Saori| Hirashita, Koji| |
| 抄録 | Diffuse idiopathic skeletal hyperostosis (DISH) predisposes the spine to highly unstable fractures because of long lever-arm biomechanics. Unstable injuries, including AO Spine Osteoporotic Fracture (OF) type 5, are typically treated with long-segment posterior instrumentation; however, pedicle-screw fixation may be infeasible in very elderly patients with severe osteoporosis, critically narrow pedicles, and/or significant comorbidities. A 93-year-old Japanese woman presented with severe back pain without apparent trauma. Computed tomography (CT) revealed a T12 fracture with DISH, classified as OF5. The pedicles were critically narrow (3.7-4.1 mm), and dual-energy X-ray absorptiometry confirmed severe osteoporosis. Because conventional pedicle-screw fixation was considered technically unsafe and excessively invasive, limited posterior stabilization was performed using a single spinous process plate spanning T10-L1. The operative time was 48 min and the estimated blood loss was 10 ml. Immediate postoperative CT confirmed appropriate implant positioning and maintained alignment. At the 1-year follow-up, CT demonstrated solid bony union with preserved alignment and no implant failure; the patient had remained pain-free and ambulatory. This case demonstrates that spinous process-plate fixation can be a minimally invasive salvage option for carefully selected very-elderly patients with DISH when pedicle-screw instrumentation is not feasible. |
| キーワード | DISH vertebral fracture osteoporosis spinous process plate |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 259 |
| 終了ページ | 264 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Resnick D and Niwayama G: Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology (1976) 119: 559-568.| Wu Y, Ye Q, He D, Wei Y, Pan Y and Wang Y: Effect of Diffuse Idiopathic Skeletal Hyperostosis on the Occurrence of Thoracolumbar Vertebral Fragility Fractures at Different Ages. Global Spine J (2025) 15: 2075-2086.| Harlianto NI, Ezzafzafi S, Foppen W, Kuperus JS, van der Horst-Bruinsma IE, de Jong PA and Verlaan JJ: The prevalence of vertebral fractures in diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis: A systematic review and meta-analysis. N Am Spine Soc J (2024) 17: 100312.| Blattert TR, Schnake KJ, Gonschorek O, Gercek E, Hartmann F, Katscher S, Mork S, Morrison R, Muller M, Partenheimer A, Piltz S, Scherer MA, Ullrich BW, Verheyden A, Zimmermann V and the Spine Section of the German Society for Orthopaedics and Trauma. Nonsurgical and Surgical Management of Osteoporotic Vertebral Body Fractures: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU). Global Spine J (2018) 8: 50-55.| Tomii M, Itoh Y, Numazawa S, Watanabe K and Nakagawa H: Spinous process plate (S-plate) fixation after posterior interbody fusion for lumbar canal stenosis due to spondylolisthesis. Neurosurg Rev (2013) 36: 139-143.| Diederichs G, Engelken F, Marshall LM, Peters K, Black DM, Issever AS, Barrett-Connor E, Orwoll E, Hamm B, Link TM and Osteoporotic Fractures in Men (MrOs) Research Group: Diffuse idiopathic skeletal hyperostosis (DISH): relation to vertebral fractures and bone density. Osteoporos Int (2011) 22: 1789-1797.| Page PS, Greeneway GP, Lake WB, Brooks NP, Josiah DT, Hanna AS and Resnick DK: Outcomes following conservative treatment of extension fractures in the setting of diffuse idiopathic skeletal hyperostosis: is external orthosis alone a reasonable option? J Neurosurg Spine (2022) 37: 927-931.| Solitro GF, Whitlock K, Amirouche F, Mehta AI and McDonnell A: Currently Adopted Criteria for Pedicle Screw Diameter Selection. Int J Spine Surg (2019) 13: 132-145.| Matsukawa K, Yato Y, Hynes RA, Imabayashi H, Hosogane N, Asazuma T, Matsui T, Kobayashi Y and Nemoto K: Cortical Bone Trajectory for Thoracic Pedicle Screws: A Technical Note. Clin Spine Surg (2017) 30: 497-504.| Wang H, Wang H, Sribastrav SS, Ye F, Liang C, Li Z, Wang J, Liu H, Wang X and Zheng Z: Comparison of pullout strength of the thoracic pedicle screw between intrapedicular and extrapedicular technique: a meta-analysis and literature review. Int J Clin Exp Med (2015) 8: 22237-22245.| Ikuma H, Takao S, Inoue Y, Hirose T, Matsukawa K and Kawasaki K: Treatment of Thoracolumbar Spinal Fracture Accompanied by Diffuse Idiopathic Skeletal Hyperostosis Using Transdiscal Screws for Diffuse Idiopathic Skeletal Hyperostosis: Preliminary Results. Asian Spine J (2021) 15: 340-348.| Hishiya T, Ishikawa T and Ota M: Posterior spinal fixation using penetrating endplate screws in patients with diffuse idiopathic skeletal hyperostosis-related thoracolumbar fractures. J Neurosurg Spine (2021) 34: 936-941.| Nakao Y SS, Kimura M, Yamada T, Yamamoto Y and Takashiba K: Spinal fusion using a spinous process plate (S-plate)- clinical results and mechanical strength. The journal of the Japan Spine Research Society (2006) 17: 119.| Ugawa R, Fujiwara Y and Matsumoto T: Clinical Outcomes of Transdiscal Screws for Thoracolumbar Spinal Fractures with Marked Anterior Distraction Gap Accompanied by Diffuse Idiopathic Skeletal Hyperostosis. Medicina (Kaunas) (2025) 61: 1-9.| |
| JaLCDOI | 10.18926/AMO/71069 |
|---|---|
| フルテキストURL | 80_4_253.pdf |
| 著者 | Ishikami, Sachiko| Tamura, Shuta| Tabuchi, Motoyasu| Yamamoto, Nao| Okamoto, Yuki| Yoshimatsu, Rika| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
| 抄録 | Lymphangioma is a benign tumor arising from lymphatic vessel proliferation and most commonly occurs in the head, neck, or axilla. Involvement of the small intestine is rare and is often overlooked as a source of obscure gastrointestinal bleeding. Because jejunal lymphangiomas frequently present with nonspecific symptoms and may escape detection by conventional upper and lower gastrointestinal endoscopy or cross-sectional imaging, diagnosis is often delayed. Advances in balloon-assisted enteroscopy have enabled direct visualization of small intestinal lesions, facilitating accurate diagnosis and appropriate therapeutic decision-making. Here, we report a case of jejunal lymphangioma presenting with severe anemia due to active bleeding, which was detected by double-balloon endoscopy and successfully managed by laparoscopic-assisted resection. This case highlights the importance of considering small intestinal lymphangioma in the differential diagnosis of unexplained gastrointestinal bleeding and underscores the clinical utility of deep enteroscopy in identifying rare but clinically significant small bowel tumors. |
| キーワード | jejunal lymphangioma double-balloon endoscopy surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 253 |
| 終了ページ | 257 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Galifer RB, Pous JG, Juskiewenski S, Pasquie M and Gaubert J: Intra-abdominal cystic lymphangiomas in childhood. Prog Pediatr Surg (1978) 11: 173-238.| Chin CC, Shiau J, Luo CW and Hou MF: Lymphangioma of the small bowel in adults: a rare cause of abdominal symptoms. Asian J Surg (2023) 46: 863-867.| Kida A, Matsuda K, Hirai S, Shimatani A, Horita Y, Hiramatsu K, Matsuda M, Ogino H, Ishizawa S and Noda Y: A pedunculated polyp-shaped small-bowel lymphangioma causing gastrointestinal bleeding and treated by double-balloon enteroscopy. World J Gastroenterol (2012) 18: 4798-4800.| Zhao N, Fu Y, Wang Z, An Q and Jia W: Submucosal cavernous lymphangioma causing jejuno-jejunal intussusception in an adult: a case report. Front Surg (2022) 9: 953840.| Hanagiri T, Baba M, Shimabukuro T, Hashimoto M, Takemoto H, Inoue A, Sugitani A and Shirakusa T: Lymphangioma in the small intestine: report of a case and review of the Japanese literature. Surg Today (1992) 22: 363-367.| Cheung DY and Choi MG: Current advances in small bowel tumors. Clin Endosc (2011) 44: 13-21.| Yamamoto H, Sekine Y, Sato Y, Higashizawa T, Miyata T, Iino S, Ido K and Sugano K: Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointest Endosc (2001) 53: 216-220.| Pennazio M, Spada C, Eliakim R, Keuchel M, May A, Mulder CJ, Rondonotti E, Adler SN, Albert J, Baltes P, Barbaro F, Cellier C, Charton JP, Delvaux M, Despott EJ, Domagk D, Klein A, McAlindon M, Rosa B, Rowse G, Sanders DS, Saurin JC, Sidhu R, Dumonceau JM, Hassan C and Gralnek IM: Small-bowel capsule endoscopy and device-assisted enteroscopy. Endoscopy (2015) 47: 352-376.| Peters FT, Rutgers EJ and Driessen WM: Intra-abdominal lymphangiomatous cysts in adults. Neth J Med (1987) 31: 152-157.| Wang ZZ, Shen LY, Zhou JJ, Tang JL, Ye LP, Shen CB, Li SW and Zhou XB: Clinical manifestation and treatment of small intestinal lymphangioma: a single-center analysis of 15 cases. Front Med (Lausanne) (2022) 9: 975698.| Iwabuchi A, Otaka M, Okuyama A, Jin M, Otani S, Itoh S, Sasahara H, Odashima M, Kotanagi H, Satoh M, Masuda H and Masamune O: Disseminated intra-abdominal cystic lymphangiomatosis with severe intestinal bleeding: a case report. J Clin Gastroenterol (1997) 25: 383-386.| Tan B, Zhang SY, Wang YN, Li Y, Shi XH and Qian JM: Jejunal cavernous lymphangioma manifested as gastrointestinal bleeding with hypogammaglobulinemia in an adult: a case report and literature review. World J Clin Cases (2020) 8: 140-148.| Meşină C, Paşalega M, Calotă F, Comănescu V, Vîlcea D, Tenea T, Mirea C and Vasile I: Hemorrhagic intestinal lymphangioma: report of a case. Chirurgia (Bucur) (2006) 101: 201-204.| Lim DR, Kuk JC, Kim T and Shin EJ: Surgery of multiple lymphangioma in the small bowel: a rare case report of chronic gastrointestinal bleeding. Ann Surg Treat Res (2018) 94: 52-56.| Barquist ES, Apple SK, Jensen DM and Ashley SW: Jejunal lymphangioma: an unusual cause of chronic gastrointestinal bleeding. Dig Dis Sci (1997) 42: 1179-1183.| Xiao NJ, Ning SB, Li T, Li BR and Sun T: Small intestinal hemolymphangioma treated with enteroscopic injection sclerotherapy: a case report and review of the literature. World J Gastroenterol (2020) 26: 1540-1545.| Yang J, Zhang Y, Kou G and Li Y: Jejunum hemolymphangioma causing refractory anemia in a young woman. Am J Gastroenterol (2020) 115: 810.| Yang SX, Zhou YH, Zhang J, Miao L, Zhong JW, Wang WX, Xu CL, Cai ZZ and Lu GR: Haemorrhagic ileal haemolymphangioma: a case report and review of the literature. J Int Med Res (2021) 49: 300060520986677.| Tomizawa Y, Garner K and Sohnen A: Lymphangioma of the small bowel mesentery: a rare intra-abdominal tumor causing anemia. Clin Gastroenterol Hepatol (2013) 11: e57.| Fang YF, Qiu LF, Du Y, Jiang ZN and Gao M: Small intestinal hemolymphangioma with bleeding: a case report. World J Gastroenterol (2012) 18: 2145-2146.| Park JG, Aubry MC, Godfrey JA and Midthun DE: Mediastinal lymphangioma: Mayo Clinic experience of 25 cases. Mayo Clin Proc (2006) 81: 1197-1203.| Landing BH and Farber S: Tumors of the cardiovascular system. Atlas of tumor pathology Armed forces Inst. Path. Washington D. C 1956.| |
| JaLCDOI | 10.18926/AMO/71067 |
|---|---|
| フルテキストURL | 80_4_241.pdf |
| 著者 | Hasegawa, Yuta| Tsujimoto, Hironori| Uehata, Naoyuki| Kariya, Risa| Ide, Asuma| Suzuki, Takafumi| Fujishima, Seiichiro| Kouzu, Keita| Yaguchi, Yoshihisa| Miyai, Kosuke| Kurihara, Ayumu| Ogata, Sho| Matsukuma, Susumu| Ueno, Hideki| |
| 抄録 | Primary hyperparathyroidism (pHPT) is typically caused by a parathyroid adenoma, although some cases arise from ectopic glands. Accurate preoperative localization is essential for guiding surgical strategy, particularly for mediastinal lesions. We report successful video-assisted thoracoscopic surgery (VATS) for an upper mediastinal parathyroid adenoma. A 68-year-old woman was referred for hypercalcemia during evaluation for recurrent ureteral stones. Laboratory tests revealed elevated serum calcium (13.2 mg/dl) and intact parathyroid hormone (iPTH) levels (266 pg/ml). Contrast-enhanced computed tomography, magnetic resonance imaging, and 99mTc-methoxyisobutylisonitrile scintigraphy identified a 20-mm mass adjacent to the right esophageal wall. VATS was performed due to the tumor’s mediastinal location. The lesion was resected with intraoperative nerve monitoring (IONM) to avoid recurrent laryngeal nerve damage. Postoperatively, iPTH and calcium levels rapidly normalized. Transient hypocalcemia and mild hoarseness occurred but resolved with calcium supplementation and conservative management. Pathological examination confirmed a parathyroid adenoma without malignancy. VATS offers a safe and minimally invasive approach for upper mediastinal parathyroid adenomas. IONM and vigilant calcium management are crucial for minimizing these complications. This case highlights the importance of comprehensive imaging, surgical planning, and postoperative care in managing upper mediastinal pHPT. |
| キーワード | primary hyperparathyroidism parathyroid neoplasm ectopic tissue video-assisted thoracoscopic surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 241 |
| 終了ページ | 246 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71066 |
|---|---|
| フルテキストURL | 80_4_233.pdf |
| 著者 | Ogawa, Sakura| Fukushima, Shinnosuke| Akazawa, Hidemasa| Namba, Sachie| Hirota, Chiyoko| Kishiue, Tomoyoshi| Ibara, Shohei| Kondo, Takayuki| Fukuda, Genshi| Iio, Koji| Tsuji, Shuma| Gotoh, Kazuyoshi| Otsuka, Fumio| Hagiya, Hideharu| |
| 抄録 | Carbapenemase-producing Enterobacterales (CPE) and extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL-E) are representative antimicrobial-resistant pathogens. We investigated the prevalence of CPE and ESBL-E in Okayama, Japan to clarify their current epidemiology and potential clinical burden. Active surveillance for CPE and ESBL-E was performed first, using stool samples submitted to the Okayama Medical Laboratory (Japan) in the years 2024-2025. Screening was performed using a selective agar (CHROMagar mSuper CARBA/ESBL). Phenotypic identification was conducted with the use of a modified carbapenem inactivation method and double-disk phenotypic confirmatory tests. Clinical information including patient age, sex, sampling date, and hospital address were collected, and the data were analyzed according to specimen origin (hospitals, clinics, and health checkups). A total of 2,000 stool samples were screened, of which two CPE isolates (0.1%) and 285 ESBL-E isolates (14.3%) were identified. By specimen origin, the ESBL-E positivity rate was significantly higher in hospitals (17.4%) than in clinics (11.8%). By age category, the late elderly (> 75 years) exhibited the highest ESBL-E positivity rate (22.6%) compared to other age groups. In the clinics and health checkups, infants (0 years) demonstrated high ESBL-E positivity rates (18.2% and 14.3%, respectively). Escherichia coli was the most common ESBL-E organism in the hospitals (77.2%), clinics (88.8%), and health checkups (87.5%). Our active screening demonstrated that the prevalences of CPE and ESBL-E were within the reported ranges; however, in this era of increasing internationalization, continuous surveillance of these notifiable pathogens is warranted. |
| キーワード | antimicrobial resistance carbapenem-resistant Enterobacteriaceae extended-spectrum β-lactamase infection prevention and control Okayama Medical Laboratory |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 233 |
| 終了ページ | 240 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Jean SS, Harnod D and Hsueh PR: Global threat of carbapenem-resistant Gram-negative bacteria. Front Cell Infect Microbiol (2022) 12: 823684.| Baek MS, Kim JH, Park JH, Kim TW, Jung HI and Kwon YS: Comparison of mortality rates in patients with carbapenem-resistant Enterobacterales bacteremia according to carbapenemase production: a multicenter propensity-score matched study. Sci Rep (2024) 14: 597.| Takei K, Ogawa M, Sakata R and Kanamori H: Epidemiological characteristics of carbapenem-resistant Enterobacterales in Japan: a nationwide analysis of data from a clinical laboratory center (2016-2022). Pathogens (2023) 12: 1246.| Yamamoto N, Asada R, Kawahara R, Hagiya H, Akeda Y and Shanmugakani RK: Prevalence of, and risk factors for, carriage of carbapenem-resistant Enterobacteriaceae among hospitalized patients in Japan. J Hosp Infect (2017) 97: 212-217.| Hagiya H, Yamamoto N, Kawahara R, Akeda Y, Shanmugakani RK and Ueda A: Risk factors for fecal carriage of IMP-6-producing Enterobacteriaceae at a long-term care hospital in Japan: a follow-up report from the northern Osaka multicentre study group. J Infect Chemother (2018) 24: 769-772.| Ohno Y, Nakamura A, Hashimoto E, Noguchi N, Matsumoto G and Fukuda S: Fecal carriage and molecular epidemiologic characteristics of carbapenemase-producing Enterobacterales in a primary care hospital in a Japanese city. J Infect Chemother (2020) 26: 928-932.| Ishii Y, Aoki K, Tateda K and Kiyota H: Multicenter collaboration study on the β-lactam-resistant Enterobacteriaceae in Japan ‒ the 65th anniversary public interest purpose project of the Japanese Society of Chemotherapy. J Infect Chemother (2017) 23: 583-586.| Nakai M, Oka K, Watanabe G, Kamei K, Tsukada N and Mori R: Epidemiology and molecular characterization of fecal carriage of third-generation cephalosporin-resistant Enterobacterales among elderly residents in Japan. J Infect Chemother (2022) 28: 569-575.| Hagiya H, Onishi Y, Shinohara N, Tokuyasu M, Imanishi A and Fukushima S: High frequency of extended-spectrum beta-lactamase-producing Enterobacteriaceae carriers at a Japanese long-term care hospital. J Infect Chemother (2022) 28: 1578-1581.| Fukushima S, Hagiya H, Uda K, Gotoh K and Otsuka F: Current prevalence of antimicrobial resistance in Okayama from a national database between 2018 and 2021. Acta Med Okayama (2023) 77: 255-262.| Fukushima S, Hagiya H, Gotoh K, Tsuji S, Iio K and Matsushita O: Detection of imported clinical strain of blaNDM-1-harbouring ST147 Klebsiella pneumoniae from a Ukrainian immigrant. J Travel Med (2024) 31: taae011.| Gotoh K, Hagiya H, Iio K, Yamada H, Matsushita O and Otsuka F: Detection of Enterobacter cloacae complex strain with a blaNDM-1-harboring plasmid from an elderly resident at a long-term care facility in Okayama, Japan. J Infect Chemother (2022) 28: 1697-1699.| Gotoh K, Miyoshi M, I Putu Bayu Mayura, Tsuji S, Iio K and Fukushima S: Phenotypic and genetic characteristics of carbapenemase-producing Enterobacterales isolates at Okayama University Hospital. Acta Med Okayama (2024) 78: 371-376.| Pierce VM, Simner PJ, Lonsway DR, Roe-Carpenter DE, Johnson JK and Brasso WB: Modified carbapenem inactivation method for phenotypic detection of carbapenemase production among Enterobacteriaceae. J Clin Microbiol (2017) 55: 2321-2333.| Kanda Y: Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplant (2013) 48: 452-458.| Bezabih YM, Bezabih A, Dion M, Batard E, Teka S and Obole A: Comparison of the global prevalence and trend of human intestinal carriage of ESBL-producing Escherichia coli between healthcare and community settings: a systematic review and meta-analysis. JAC Antimicrob Resist (2022) 4: dlac048.| Ng RWY, Yang L, Lau SH, Hawkey P and Ip M: Global prevalence of human intestinal carriage of ESBL-producing Escherichia coli during and after the COVID-19 pandemic. JAC Antimicrob Resist (2025) 7: dlaf001.| Raffelsberger N, Buczek DJ, Svendsen K, Småbrekke L, Pöntinen AK and Löhr IH: Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates. mSphere (2023) 8: e00025-23.| Islam K, Heffernan AJ, Naicker S, Henderson A, Chowdhury MAH and Roberts JA: Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia. Future Microbiol (2021) 16: 521-535.| Rahaman A, Mimi A, Antor MTH, Bakhtiyar Z, Hasan MAE and Fahim NAI: Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated from animals in Bangladesh: a systematic review and meta-analysis. One Health (2025) 21: 101237.| Xie Y, Srivastava IM, Jing F, Ma C, Wu X, Chen Y, Du Y, Low XYC, Ping Y, Pan J, Gupta A, Graves N and Mo Y: One Health perspective of antibiotic resistance in Enterobacterales from Southeast Asia: a systematic review and meta-analysis. Res Sq (2025) 16: 1694.| Jia P, Zhu Y, Li X, Kudinha T, Yang Y and Zhang G: High prevalence of extended-spectrum beta-lactamases in Escherichia coli strains collected from strictly defined community-acquired urinary tract infections in adults in China: a multicenter prospective clinical microbiological and molecular study. Front Microbiol (2021) 12: 663033.| Chao CM, Lai CC and Yu WL: Epidemiology of extended-spectrum β-lactamases in Enterobacterales in Taiwan for over two decades. Front Microbiol (2022) 13: 1060050.| Chaisaeng S, Chopjitt P, Kasemsiri P, Putthanachote N, Boueroy P and Takeuchi D: High prevalence of ESBL-producing Escherichia coli phylogroup B2 clinical isolates in northeastern Thailand. BMC Microbiol (2024) 24: 425.| Sawatwong P, Sapchookul P, Whistler T, Gregory CJ, Sangwichian O and Makprasert S: High burden of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae bacteremia in older adults: a seven-year study in two rural Thai provinces. Am J Trop Med Hyg (2019) 100: 943-951.| Sunarno S, Puspandari N, Fitriana F, Nikmah UA, Idrus HH and Panjaitan NSD: Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Indonesia and Southeast Asian countries: GLASS data 2018. AIMS Microbiol (2023) 9: 218-227.| Kawamura K, Nagano N, Suzuki M, Wachino JI, Kimura K and Arakawa Y: ESBL-producing Escherichia coli and its rapid rise among healthy people. Food Saf (2017) 5: 122-150.| Shibuki R, Nishiyama M, Mori M, Baba H, Kanamori H and Watanabe T: Characterization of extended-spectrum β-lactamase-producing Escherichia coli isolated from municipal and hospital wastewater in Japan. J Glob Antimicrob Resist (2023) 32: 145-151.| Kawata S, Morimoto S, Kosai K, Kawamoto Y, Nakashima Y and Morinaga Y: The fecal carriage rate of extended-spectrum β-lactamase-producing or carbapenem-resistant Enterobacterales among Japanese infants in the community at the 4-month health examination in a rural city. Front Cell Infect Microbiol (2023) 13: 1168451.| |
| JaLCDOI | 10.18926/AMO/71065 |
|---|---|
| フルテキストURL | 80_4_227.pdf |
| 著者 | Kashihara, Kenichi| Hamaguchi, Toshikazu| Takeda, Yasuko| |
| 抄録 | The impact of migraines as a risk factor for cervicocerebral artery dissection was retrospectively investigated in patients who had a cervicocerebral artery dissection. We first evaluated the patients’ medical records and history of migraine and then calculated the proportion of patients with migraine as well as the relevant vascular risk factors. The prevalence of migraine with respect to the location of the cervicocerebral artery dissection was also identified. Sixty-two patients (37 men, 25 women) had both a cerebral artery dissection and a record of migraine. Among them, 93.5% presented with an isolated headache, and 6.5% presented with a related stroke. Regarding the locations of the artery dissection, 56 (90.3%) were in the intracranial vertebral artery (VA), three (4.8%) were in the internal carotid artery, and one case each (1.6%) was in an anterior cerebral artery, basilar artery (BA), and both the VA and BA. Among the patients with VA dissection, 42 (73.7%) presented with migraines. Among the four patients with dissection of an artery of anterior circulation, only one (25%) had a migraine history. The frequency of migraines tended to be higher in the patients with VA dissection compared to those with a dissection of arteries of anterior circulation. These data suggest that (i) migraine is a potent risk factor for cerebral artery dissection, especially intracranial VA dissection, and (ii) the intracranial VA may be more susceptible to dissection compared to arteries of anterior circulation. |
| キーワード | cervicocerebral artery dissection isolated headache migraine risk factor vertebral artery |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 227 |
| 終了ページ | 231 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Miyake, Nozomi| Yasugi, Kengo| Takaki, Akinobu| Matsumoto, Kazuyuki| Otsuka, Motoyuki| |
| キーワード | biliary diseases cholecystectomy gall bladder liver function post cholecystectomy primary sclerosing cholangitis (psc) |
| 発行日 | 2025-03-06 |
| 出版物タイトル | Cureus |
| 巻 | 17巻 |
| 号 | 3号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | e80184 |
| ISSN | 2168-8184 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Copyright 2025 Miyake et al. |
| 論文のバージョン | publisher |
| PubMed ID | 40190977 |
| DOI | 10.7759/cureus.80184 |
| 関連URL | isVersionOf https://doi.org/10.7759/cureus.80184 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Bose, Puja| Halder, Gourab| Kayet, Pratanu| Chowdhury, Goutam| Basak, Surajit| Roy, Deboleena| Imamura, Daisuke| Miyoshi, Shin-ichi| Morita, Masatomo| Ramamurthy, Thandavarayan| Koley, Hemanta| Das, Santasabuj| Mukhopadhyay, Asish Kumar| |
| キーワード | dysentery AMR XDR Shigella spp. CTX-M plasmid transconjugants PFGE WGS |
| 発行日 | 2026-07-24 |
| 出版物タイトル | Microbiology Spectrum |
| 出版者 | American Society for Microbiology |
| 開始ページ | e02824-25 |
| ISSN | 2165-0497 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 Bose et al. |
| 論文のバージョン | publisher |
| PubMed ID | 42496106 |
| DOI | 10.1128/spectrum.02824-25 |
| Web of Science KeyUT | 001829299600001 |
| 関連URL | isVersionOf https://doi.org/10.1128/spectrum.02824-25 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Konuma, Takaaki| Kameda, Kazuaki| Morita, Kaoru| Kondo, Tadakazu| Kimura, Fumihiko| Nakasone, Hideki| Ouchi, Fumihiko| Uchida, Naoyuki| Tanaka, Masatsugu| Nishida, Tetsuya| Fukuda, Takahiro| Hasegawa, Yuta| Sakata‐Yanagimoto, Mamiko| Onizuka, Makoto| Sawa, Masashi| Ota, Shuichi| Asada, Noboru| Fujiwara, Shin‐Ichiro| Yoshihara, Satoshi| Ishimaru, Fumihiko| Yoshimitsu, Makoto| Kanda, Yoshinobu| Ohbiki, Marie| Atsuta, Yoshiko| Yanada, Masamitsu| |
| 発行日 | 2024-11-20 |
| 出版物タイトル | American Journal of Hematology |
| 巻 | 100巻 |
| 号 | 1号 |
| 出版者 | Wiley |
| 開始ページ | 66 |
| 終了ページ | 77 |
| ISSN | 0361-8609 |
| NCID | AA00520673 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 39564683 |
| DOI | 10.1002/ajh.27521 |
| Web of Science KeyUT | 001358876600001 |
| 関連URL | isVersionOf https://doi.org/10.1002/ajh.27521 |
| JaLCDOI | 10.18926/AMO/70851 |
|---|---|
| フルテキストURL | 80_3_159.pdf |
| 著者 | Ikeda, Tomoko| Nakatsuka, Mikiya| |
| 抄録 | Endometriosis symptoms often first appear during adolescence, yet delays in seeking gynecologic consultation remain a persistent challenge worldwide. Despite growing international evidence, the specific patterns of symptom recognition and consultation delay among Japanese women — particularly in relation to self-monitoring behaviors and cultural barriers — remain poorly understood. This study aimed to provide foundational data to guide menstrual education and preconception care strategies by conducting a cross-sectional online survey with retrospective recall among women with endometriosis to assess menstrual characteristics and symptom patterns from adolescence to initial care seeking. The survey was conducted in Japan in January 2024 and enrolled 166 women with endometriosis and 200 controls. Participants reported current and adolescent menstrual characteristics, symptom recognition, analgesic and low-dose estrogen–progestin use, school/work impact, and age at first gynecologic consultation for menstrual problems. Women with endometriosis reported heavier bleeding, stronger pain, and greater school/work absence than controls, both currently and retrospectively. The median age at first recognition of heavy bleeding or school/work absence was 16 years, whereas consultation occurred at approximately 21-23 years, indicating a consultation delay of 5-6 years. Notably, while self-monitoring of symptoms was more frequent among women with endometriosis, it only modestly shortened consultation delays. This study provides evidence from Japan that consultation delay persists despite active self-monitoring of symptoms, highlighting the influence of educational and cultural barriers on health-seeking behavior. These findings underscore the importance of integrating menstrual education with clinical guidance to promote timely gynecologic consultation. |
| キーワード | endometriosis adolescence menstrual disorders consultation delay health-seeking behavior |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-06 |
| 巻 | 80巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 159 |
| 終了ページ | 168 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 42374748 |
| Web of Science KeyUT | 001812989700001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yoshida, Ryuichi| Takagi, Kosei| Yasui, Kazuya| Hioki, Masayoshi| Okabayashi, Takehiro| Kojima, Toru| Endo, Yoshikatsu| Nobuoka, Daisuke| Sui, Kenta| Inagaki, Masaru| Shinoura, Susumu| Kimura, Masashi| Matsuda, Tatsuo| Aoki, Hideki| Fujiwara, Toshiyoshi| |
| キーワード | pancreatic cancer resectable upfront surgery recurrence nomogram |
| 発行日 | 2026-04-07 |
| 出版物タイトル | Cancers |
| 巻 | 18巻 |
| 号 | 7号 |
| 出版者 | MDPI AG |
| 開始ページ | 1181 |
| ISSN | 2072-6694 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 41976403 |
| DOI | 10.3390/cancers18071181 |
| Web of Science KeyUT | 001739239200001 |
| 関連URL | isVersionOf https://doi.org/10.3390/cancers18071181 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takagi, Kosei| Yoshida, Ryuichi| Yasui, Kazuya| Hioki, Masayoshi| Okabayashi, Takehiro| Kojima, Toru| Endo, Yoshikatsu| Nobuoka, Daisuke| Sui, Kenta| Inagaki, Masaru| Shinoura, Susumu| Kimura, Masashi| Matsuda, Tatsuo| Aoki, Hideki| Fujiwara, Toshiyoshi| |
| キーワード | pancreatic cancer resectable upfront Surgery outcomes |
| 発行日 | 2025-11-18 |
| 出版物タイトル | Cancers |
| 巻 | 17巻 |
| 号 | 22号 |
| 出版者 | MDPI AG |
| 開始ページ | 3694 |
| ISSN | 2072-6694 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 41301059 |
| DOI | 10.3390/cancers17223694 |
| Web of Science KeyUT | 001625523900001 |
| 関連URL | isVersionOf https://doi.org/10.3390/cancers17223694 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nakaya, Yosuke| Nakamae, Hirohisa| Sugita, Junichi| Kanda, Junya| Hasegawa, Yuta| Eto, Tetsuya| Fukuda, Takahiro| Kurita, Naoki| Hiramoto, Nobuhiro| Nagafuji, Koji| Ota, Shuichi| Asada, Noboru| Ando, Toshihiko| Kawakita, Toshiro| Akasaka, Takashi| Mori, Yasuo| Kamimura, Tomohiko| Onizuka, Makoto| Atsuta, Yoshiko| Nakasone, Hideki| |
| キーワード | Post-transplant cyclophosphamide Matched donor Haploidentical donor Graft-versus-host disease Hematological malignancies. |
| 発行日 | 2026-04-20 |
| 出版物タイトル | Annals of Hematology |
| 巻 | 105巻 |
| 号 | 5号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 255 |
| ISSN | 1432-0584 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2026 |
| 論文のバージョン | publisher |
| PubMed ID | 42008176 |
| DOI | 10.1007/s00277-026-07014-z |
| Web of Science KeyUT | 001744329600001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00277-026-07014-z |
| 著者 | Nomura, Emi| Morihara, Ryuta| Osakada, Yosuke| Yunoki, Taijun| Takemoto, Mami| Yamashita, Toru| Ishiura, Hiroyuki| |
|---|---|
| キーワード | Amyotrophic lateral sclerosis ALS Gold Coast criteria Revised El Escorial criteria Awaji criteria |
| 備考 | © 2026 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jan. 2027.| |
| 発行日 | 2026-02 |
| 出版物タイトル | Journal of the Neurological Sciences |
| 巻 | 481巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 125733 |
| ISSN | 0022-510X |
| NCID | AA00703265 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 Elsevier B.V. |
| 論文のバージョン | author |
| PubMed ID | 41534442 |
| DOI | 10.1016/j.jns.2026.125733 |
| Web of Science KeyUT | 001668514200001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jns.2026.125733 |
| JaLCDOI | 10.18926/AMO/70455 |
|---|---|
| フルテキストURL | 80_2_131.pdf |
| 著者 | Nakata, Shunsuke| Takatsu, Fumiaki| Mikuriya, Yoshihiro| Kakishita, Tomokazu| Hato, Shinji| Ohta, Koji| Kobatake, Takaya| |
| 抄録 | Colorectal surgery is associated with a high incidence of postoperative complications regardless of the advances in surgical techniques and multidisciplinary treatment. Proteinuria is common in patients with malignancies, but few studies have investigated the association between preoperative proteinuria and patient prognoses, especially postoperative complications. We investigated the impact of proteinuria on patients undergoing colorectal surgery in a single-center, retrospective cohort study of 767 patients who underwent surgical resection for colorectal cancer between January 2016 and December 2022 at the National Hospital Organization Shikoku Cancer Center. Among them, 81 patients with preoperative proteinuria were compared with the control group of 686 patients without proteinuria. Our analyses revealed that the patients with proteinuria had malnutrition with a significantly lower prognostic nutritional index compared to the no-proteinuria control group (p<0.001). The proteinuria group had a significantly advanced tumor stage (p=0.005), experienced more bleeding during the surgery (p=0.002), and required more transfusions (p<0.001). Postoperative complications were significantly more frequent in the proteinuria group (p=0.03), thus demonstrating that proteinuria was independently associated with postoperative complications (p=0.045). Proteinuria in patients undergoing colorectal cancer surgery can therefore be considered a risk factor for postoperative complications. |
| キーワード | colorectal cancer surgery proteinuria complication malnutrition |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 131 |
| 終了ページ | 139 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 42025434 |
| Web of Science KeyUT | 001761342100006 |
| JaLCDOI | 10.18926/AMO/70453 |
|---|---|
| フルテキストURL | 80_2_109.pdf |
| 著者 | Sonoi, Mika| Sonoi, Norihiro| Koyama, Yoko| |
| 抄録 | This study examined the effects of interprofessional education (IPE) on dietetics students during clinical training, focusing on changes in their attitudes toward IPE and their fundamental competencies. Eighty third-year female students (mean age, 21.0 years) at a Japanese women’s university participated. Self-administered surveys were conducted before and after clinical training to assess attitudes toward IPE using the Readiness for Interprofessional Learning Scale (RIPLS) and the Shakaijin Kisoryoku (SKL; Fundamental Competencies for Working Persons) scale. Quantitative data were analyzed using paired t-tests, chi-squared tests, and cluster analyses. Qualitative data from open-ended responses were analyzed thematically. RIPLS and SKL scores increased significantly, from 65.3 to 68.9, and from 28. 4 to 33. 2, respectively (p<0.001). All 12 SKL items showed significant improvement. In free responses, “initiative” (66 mentions), “communication” (10), and “execution” (8) were the most frequently cited as improved competencies. Cluster analysis identified three groups: increasing scores (n=25), high baseline (n=30), and minimal change (n=25). No significant correlation was found between changes in RIPLS and SKL scores (r=−0.108, p=0.355). IPE integrated into clinical training may enhance dietetics students’ attitudes toward interprofessional collaboration and contribute to the development of professional identity. Individualized, phased IPE implementation is recommended to accommodate differences in learner readiness. |
| キーワード | interprofessional education dietetics students clinical training professional competencies transformative learning |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 109 |
| 終了ページ | 117 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 42025432 |
| Web of Science KeyUT | 001761342100004 |
| JaLCDOI | 10.18926/AMO/70450 |
|---|---|
| フルテキストURL | 80_2_075.pdf |
| 著者 | Lin, Deting| Horita, Masahiro| Watanabe, Masahito| Hasei, Joe| Ohtsuki, Takashi| Otsuka, Noriaki| Ichikawa, Chinatsu| Shimizu, Noriyuki| Naniwa, Shuichi| Ozaki, Toshifumi| Nishida, Keiichiro| |
| 抄録 | A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and is upregulated in the synovial tissue of osteoarthritis (OA). However, the underlying mechanisms of ADAM12 on rheumatoid arthritis (RA) synovial cell proliferation remain unknown. Here, we investigated the role of ADAM12 in the proliferation of RA synovial fibroblasts (RASFs). The expression and localization of ADAM12 in RA synovial tissues were examined by immunohistochemistry and compared with OA and healthy control (HC) synovial tissues. The effect of inflammatory cytokines (TNF-α, TGF-β1, and PDGF-BB) on ADAM12 expression in RASFs from RA patients was examined by real-time RT-PCR. The effect of ADAM12 knock-down by ADAM12 siRNA and ADAM12 overexpression on cell proliferation of RASFs were examined by WST-1 assay. ADAM12 was identified predominantly in RA synovial tissue rather than OA and HC synovial tissues. Stimulation with TGF-β1 upregulated the expression of ADAM12 and cell proliferation of RASFs. ADAM12 siRNA suppressed TGF-β1-induced cell proliferation of RASFs, while ADAM12 overexpression promoted the cell proliferation of RASFs. These findings demonstrate that ADAM12 may have a key role in TGF-β1-induced cell proliferation of synovial fibroblasts in patients with RA. |
| キーワード | rheumatoid arthritis synovial tissue TGF-β1 ADAM12 cell proliferation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-04 |
| 巻 | 80巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 75 |
| 終了ページ | 83 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 42025429 |
| Web of Science KeyUT | 001761342100001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Miyoshi, Kentaroh| Otani, Shinji| Sugimoto, Seiichiro| Tanaka, Shin| Okazaki, Mikio| Toyooka, Shinichi| |
| キーワード | Anti-thymocyte globulin Acute antibody-mediated rejection Treatment Lung transplantation |
| 発行日 | 2026-05 |
| 出版物タイトル | Respiratory Investigation |
| 巻 | 64巻 |
| 号 | 3号 |
| 出版者 | Elsevier BV |
| 開始ページ | 101428 |
| ISSN | 2212-5345 |
| NCID | AA12579673 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 The Authors. |
| 論文のバージョン | publisher |
| DOI | 10.1016/j.resinv.2026.101428 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.resinv.2026.101428 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kuribayashi, Tadahiro| Makimoto, Go| Ohashi, Kadoaki| Tomida, Shuta| Inoue, Hirofumi| Yokoyama, Toshihide| Kuyama, Shoichi| Kato, Yuka| Kudo, Kenichiro| Horita, Naokatsu| Kayatani, Hiroe| Inoue, Masaaki| Sugimoto, Keisuke| Ninomiya, Kiichiro| Maeda, Yoshinobu| Togashi, Yosuke| Hotta, Katsuyuki| |
| 発行日 | 2026-02-01 |
| 出版物タイトル | Cancer Research Communications |
| 巻 | 6巻 |
| 号 | 2号 |
| 出版者 | American Association for Cancer Research (AACR) |
| 開始ページ | 284 |
| 終了ページ | 293 |
| ISSN | 2767-9764 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 The Authors |
| 論文のバージョン | publisher |
| PubMed ID | 41529251 |
| DOI | 10.1158/2767-9764.crc-25-0545 |
| Web of Science KeyUT | 001693865300001 |
| 関連URL | isVersionOf https://doi.org/10.1158/2767-9764.crc-25-0545 |