result 1486 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kuribayashi, Tadahiro| Makimoto, Go| Ohashi, Kadoaki| Tomida, Shuta| Inoue, Hirofumi| Yokoyama, Toshihide| Kuyama, Shoichi| Kato, Yuka| Kudo, Kenichiro| Horita, Naokatsu| Kayatani, Hiroe| Inoue, Masaaki| Sugimoto, Keisuke| Ninomiya, Kiichiro| Maeda, Yoshinobu| Togashi, Yosuke| Hotta, Katsuyuki| |
| Published Date | 2026-02-01 |
| Publication Title | Cancer Research Communications |
| Volume | volume6 |
| Issue | issue2 |
| Publisher | American Association for Cancer Research (AACR) |
| Start Page | 284 |
| End Page | 293 |
| ISSN | 2767-9764 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Authors |
| File Version | publisher |
| PubMed ID | 41529251 |
| DOI | 10.1158/2767-9764.crc-25-0545 |
| Web of Science KeyUT | 001693865300001 |
| Related Url | isVersionOf https://doi.org/10.1158/2767-9764.crc-25-0545 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tanaka, Tamaki| Takehara, Kazuhiro| Usami, Tomoka| Ishikawa, Masako| Kondo, Eiji| Kagabu, Masahiro| Hirabayashi, Kei| Matsumura, Noriomi| Sato, Shinya| Nishimura, Masato| Arakawa, Atsushi| Nakamura, Keiichiro| Konno, Yosuke| Fujiwara, Satoe| Sueoka, Kotaro| Nakamura, Hiroko| Koh, Iemasa| Ito, Kimihiko| Hongo, Atsushi| |
| Keywords | Ovarian cancer Bevacizumab Chemotherapy Platinum-sensitive relapse Platinum-free interval |
| Published Date | 2025-06 |
| Publication Title | Gynecologic Oncology Reports |
| Volume | volume59 |
| Publisher | Elsevier BV |
| Start Page | 101740 |
| ISSN | 2352-5789 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Authors. |
| File Version | publisher |
| PubMed ID | 40297564 |
| DOI | 10.1016/j.gore.2025.101740 |
| Web of Science KeyUT | 001475132400001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.gore.2025.101740 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Horita, Masahiro| Kiso, Yohei| Nasu, Yoshihisa| Nakahara, Ryuichi| Saiga, Kenta| Ozaki, Toshifumi| Nishida, Keiichiro| |
| Keywords | forefoot surgery foot length foot width rheumatoid arthritis |
| Published Date | 2026-02-28 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume15 |
| Issue | issue5 |
| Publisher | MDPI AG |
| Start Page | 1877 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 by the authors. |
| File Version | publisher |
| DOI | 10.3390/jcm15051877 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm15051877 |
| JaLCDOI | 10.18926/AMO/70075 |
|---|---|
| FullText URL | 80_1_069.pdf |
| Author | Wakatsuki, Shinya| Sakamoto, Shinya| Ueno, Akiko| Namba, Takaomi| Yamamoto, Yorito| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
| Abstract | Patients with hepatocellular carcinoma (HCC) and extensive peritoneal dissemination generally have a poor prognosis and are often resistant to systemic therapy. We report the case of a 47-year-old woman with HCC and massive peritoneal dissemination who presented with malignant ascites requiring repeated cell-free and concentrated ascites reinfusion therapy and peritoneovenous shunt placement, as well as malignant pleural effusion requiring pleurodesis. Combined immunotherapy with durvalumab/tremelimumab was initiated;however, disease progression was observed after three treatment courses, prompting a switch to lenvatinib therapy. Two months after initiation of lenvatinib, CT imaging demonstrated complete disappearance of arterial enhancement in the primary hepatic lesion, along with reduction in the size of peritoneal dissemination nodules. Thirteen months after switching to lenvatinib (16 months after the initial diagnosis), the alpha-fetoprotein level continued to decrease, and the disease remained stable under treatment. Despite the extremely high tumor burden, lenvatinib achieved disease stabilization and symptomatic improvement. |
| Keywords | diagnostic laparoscopy hepatocellular carcinoma peritoneal dissemination lenvatinib |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-02 |
| Volume | volume80 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 69 |
| End Page | 74 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41748152 |
| Web of Science KeyUT | 001712986800001 |
| JaLCDOI | 10.18926/AMO/70073 |
|---|---|
| FullText URL | 80_1_055.pdf |
| Author | Akazawa, Hidemasa| Hagiya, Hideharu| Fukushima, Shinnosuke| Yamamoto, Shohei| Nakano, Yasuhiro| Otsuka, Fumio| |
| Abstract | In Japan, antiviral agents for COVID-19 were freely available until September 2023 as part of national policy. This study evaluated changes in these agents’ prescribing patterns and the patient outcomes following the policy shift. We conducted a multicenter retrospective study at four hospitals in Japan’s Okayama and Kagawa prefectures from January 2022 to March 2024. The study period was divided into the public-expenditure phase (January 2022 to September 2023) and the post-expenditure phase (October 2023 to March 2024). We extracted the hospitalized patients’ clinical data from the electronic database. The study’s primary outcome was the antiviral prescription rate; the secondary outcome was in-hospital mortality. Among the 302 hospitalized patients (median age 85 years), 52.0% were classified as having a mild condition. Of the patients with mild conditions, 37.7% were diagnosed in outpatient settings prior to hospitalization. During the public-expenditure phase, 47.4% of the patients received antivirals as outpatients, mainly molnupiravir (80.9%). In the post-expenditure period, 80.0% of the patients were prescribed antivirals, mostly molnupiravir (91.7%). The antiviral prescription rate was significantly higher after the policy change. The overall in-hospital mortality was 15.8%, with no significant difference between the two periods (17.0% vs. 10.5%). Despite the termination of government funding, antiviral prescriptions remained frequent at community hospitals located in highly aging regions of western Japan such as Okayama and Kagawa prefectures. Mortality remains high among the elderly, highlighting the need for continued antiviral therapy and booster vaccinations. |
| Keywords | coronavirus disease 2019 public expenditure prescribing pattern prognosis Japan |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-02 |
| Volume | volume80 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 55 |
| End Page | 62 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41748150 |
| Web of Science KeyUT | 001712994500007 |
| JaLCDOI | 10.18926/AMO/70070 |
|---|---|
| FullText URL | 80_1_031.pdf |
| Author | Ishibashi, Kyota| Oishi, Hirotaka| Araki, Ryo| Kawamura, Kosuke| Sasaki, Isamu| Sasaki, Eiji| Kamada, Hikaru| Kogawa, Masakazu| Tanaka, Sunao| Numasawa, Takuya| Ishibashi, Yasuyuki| |
| Abstract | We investigated global alignment changes following total hip arthroplasty (THA) and predictive alignment parameters for increased cup anteversion (CA) by retrospectively analyzing the primary THA data of 75 patients treated at our hospital (49 women, 26 men; age 65.1±5.7 years, BMI 28.3±3.4 kg/m2). Global alignment parameters, i.e., the anterior pelvic plane angle (APPa) and proximal femoral shaft angle (PFSa) and other alignment parameters were measured. CA was evaluated based on the patients’ standing coronal radiographs. ΔCA was defined as the difference in CA from 2 weeks before to 1 year after each THA. We classified the cases as stable (S) (CA < 10°; n=63) and pelvic retroversion (R) (CA ≥ 10°; n=12) groups. Associations between ΔCA and alignment parameters were evaluated by linear regression and a receiver operating characteristic (ROC) analysis. A significant decrease in the PFSa occurred between the 2-week and 1-year post-THA timepoints (7.8±4.3° vs. 4.2±3.6°, p<0.001), with no notable change in other alignment parameters. At 1-year post-THA, the CA of 12 (16%) patients had increased to 4.5±4.4°. Only the preoperative APPa was positively associated with ΔCA (β=0.165, p=0.020). The ROC analysis revealed that the optimal cut-off value for increased CA in the APPa is 2.1° (area under the curve, 0.700; p=0.020; odds ratio, 4.80). The APPa change predicted increased CA, which emphasizes the importance of the use of preoperative standing radiography for identifying the optimal cup positioning for post-THA changes in CA. |
| Keywords | total hip arthroplasty global alignment anterior pelvic plane cup anteversion pelvic tilt |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-02 |
| Volume | volume80 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 31 |
| End Page | 37 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41748147 |
| Web of Science KeyUT | 001712994500004 |
| JaLCDOI | 10.18926/AMO/70068 |
|---|---|
| FullText URL | 80_1_009.pdf |
| Author | Sugahara, Kentaro| Kondo, Takashi| Miyatake, Nobuyuki| Nishi, Hiroyuki| Ujike, Kazuhiro| Koumoto, Kiichi| Namio, Keiichi| Hishii, Shuhei| Katayama, Akihiko| Suzuki, Hiromi| Yamamoto, Yorimasa| |
| Abstract | Appropriate treatments for chronic hemodialysis patients are a public health challenge in Japan. Sedentary behavior appears to be closely associated with these patients’ survival. We thus sought to develop a nomogram that predicts survival based on the duration of chronic hemodialysis patients’ sedentary behavior. One hundred twenty-four patients under chronic hemodialysis (73 men, 51 women, age 71.7±11.1 years) were enrolled in this cohort study. The patients wore a triaxial accelerometer that measured both their sedentary behavior, i.e., total sedentary behavior (minutes) and their maximum sedentary bouts (min) on non-hemodialysis days. We obtained the Kaplan-Meier curve and used the log-rank test and a Cox proportional hazards model to evaluate the relationship between the patients’ sedentary behavior and their survival. We also used a Cox proportional hazards model to develop a nomogram for the patients’ 5-year survival rate. Forty-six patients died during the follow-up period. When we stratified the patients by the medians of total sedentary behavior and maximum sedentary bouts, we observed significant between-group differences. After adjustment for confounding factors in a Cox proportional hazards model, total sedentary behavior and maximum sedentary bouts were identified as critical survival factors, and we generated a nomogram using an index of sedentary behavior. Our analysis results demonstrated that sedentary behavior on non-dialysis days was closely associated with the survival of the chronic hemodialysis patients, suggesting that a decrease in sedentary behavior would prolong their survival. The nomogram developed herein based on sedentary behavior may be useful for predicting the outcomes of chronic hemodialysis patients. |
| Keywords | nomogram chronic hemodialysis sedentary behavior Cox proportional hazards model Kaplan- Meier curve |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-02 |
| Volume | volume80 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 9 |
| End Page | 16 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41748145 |
| Web of Science KeyUT | 001712994500002 |
| FullText URL | fulltext20260205-01.pdf |
|---|---|
| Author | Hanaya, Tadashi| Yamamoto, Hiroshi| |
| Keywords | pteridine pterin glycoside biopterin ciliapterin neopterin limipterin tepidopterin asperopterin-A protecting group glycosylation |
| Note | This is the peer reviewed version of the following article: Hanaya, T. and Yamamoto, H. (2013), Synthesis of biopterin and related pterin glycosides. IUBMB Life, 65: 300-309. https://doi.org/10.1002/iub.1137, which has been published in final form at https://doi.org/10.1002/iub.1137. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| Published Date | 2013-02-22 |
| Publication Title | IUBMB Life |
| Volume | volume65 |
| Issue | issue4 |
| Publisher | Wiley |
| Start Page | 300 |
| End Page | 309 |
| ISSN | 1521-6543 |
| NCID | AA11380907 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2013 International Union of Biochemistry and Molecular Biology, Inc. |
| File Version | author |
| PubMed ID | 23436386 |
| DOI | 10.1002/iub.1137 |
| Web of Science KeyUT | 000316570600002 |
| Related Url | isVersionOf https://doi.org/10.1002/iub.1137 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Toshiki| Nakamura, Shin| Ito‐Shinoda, Yuki| Sakamoto, Mai| Ishii, Takayuki| Nonomura, Yasuki| Ideguchi, Hidetaka| Okubo, Keisuke| Takeuchi‐Hatanaka, Kazu| Omori, Kazuhiro| Yamamoto, Tadashi| Takashiba, Shogo| |
| Keywords | autologous bone graft fibroblast growth factor-2 periodontal pocket periodontal regeneration periodontitis vertical bone defect |
| Published Date | 2026-01-19 |
| Publication Title | Journal of Periodontology |
| Publisher | Wiley |
| ISSN | 0022-3492 |
| NCID | AA00704406 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Author(s). |
| File Version | publisher |
| PubMed ID | 41553860 |
| DOI | 10.1002/jper.70060 |
| Web of Science KeyUT | 001664142500001 |
| Related Url | isVersionOf https://doi.org/10.1002/jper.70060 |
| JaLCDOI | 10.18926/AMO/69850 |
|---|---|
| FullText URL | 79_6_463.pdf |
| Author | Asano, Yudai| Nishihara, Chika| Kitayama, Takahiro| Okawa, Nanako| Makimoto, Satoko| Higaki, Fumiyo| Kojima, Katsuhide| Sugihara, Hanako| Ida, Naoyuki| Yanai, Hiroyuki| Hiraki, Takao| |
| Abstract | We present a case of a woman in her 70s who was diagnosed with mesonephric adenocarcinoma of the uterine cervix, following biopsy and surgery. Preoperative MRI revealed a 7-cm, well-defined circumferential cervical mass with left lateral wall predominance, bulging into the uterine cavity and vagina. The lesion showed intermediate signal intensity on T2-weighted images, diffusion restriction, and early contrast enhancement weaker than that of the myometrium, followed by washout on contrast-enhanced imaging. The circumferential growth pattern with the lateral wall predominance and its imaging characteristics may suggest this rare entity be routinely included in the differential diagnosis of cervical cancers. |
| Keywords | mesonephric adenocarcinoma cervical cancer MRI imaging characteristics HPV-independent adenocarcinoma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 463 |
| End Page | 468 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443809 |
| Web of Science KeyUT | 001674277500009 |
| JaLCDOI | 10.18926/AMO/69848 |
|---|---|
| FullText URL | 79_6_451.pdf |
| Author | Hagihara, Moe| Seike, Keisuke| Hayashino, Kenta| Yasuhara, Takao| Kin, Kyohei| Hirata, Yuichi| Kobayashi, Hiroki| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Fujii, Nobuharu| Maeda, Yoshinobu| |
| Abstract | Emicizumab, a bispecific monoclonal antibody, benefits patients with severe hemophilia A. It alters laboratory assessments of coagulation activity, requiring anti-idiotype monoclonal antibodies for accurate monitoring. A 64-year-old man, receiving emicizumab regularly, was admitted for laminoplasty. We planned to use FVIII replacement during the perioperative period after confirming the disappearance of inhibitors, monitoring coagulation activity with anti-idiotype monoclonal antibodies. Activated partial thromboplastin time was prolonged on postoperative day 2, prompting an immediate switch to eptacog alfa. The patient recovered without bleeding. This case underscores the necessity of anti-idiotype monoclonal antibodies for accurate monitoring. |
| Keywords | emicizumab eptacog alfa hemophilia A inhibitor anti-idiotype monoclonal antibodies to emicizumab |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 451 |
| End Page | 455 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443807 |
| Web of Science KeyUT | 001674277500007 |
| JaLCDOI | 10.18926/AMO/69847 |
|---|---|
| FullText URL | 79_6_445.pdf |
| Author | Matsumi, Junya| |
| Abstract | Our hospital began a PERIO program (perioperative patient management by a multi-disciplinary team from multiple departments) in 2016 to improve patient outcomes. We retrospectively analyzed the clinical effects of the PERIO program regarding the postoperative hospital stay (PHS) in the patients aged ≥ 18 years who underwent long lower-abdominal surgery at our hospital during the period April 2019 to March 2023. We excluded the cases of patients whose general anesthesia use was < 8 h, those for whom another surgery was performed simultaneously at another site, and emergency surgeries. The outcome was prolonged PHS, defined as exceeding the scheduled number of days specified in the patient’s clinical pathway. Among the 480 patients, prolonged PHS was observed for 270 patients (56.3%). In a multivariate logistic regression using advanced age, sex, high-risk general state, surgery requiring colon resection, serious adverse events (SAEs), and PERIO use, the following were associated with prolonged PHS: advance age (odds ratio [OR] 4.91, 95% confidence interval [CI]: 2.68-8.99, p=0.01), surgery requiring colon resection (OR 4.91, 95%CI: 2.68-8.99, p<0.001), SAE (OR 18.7, 95%CI: 7.22-48.2, p<0.001), and PERIO (OR 0.25, 95%CI: 0.13-0.47, p<0.001). The use of the PERIO program was thus beneficially associated with PHS after long lower-abdominal surgery. |
| Keywords | hospital stay ERAS surgery cancer perioperative management |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 445 |
| End Page | 449 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443806 |
| Web of Science KeyUT | 001674277500006 |
| JaLCDOI | 10.18926/AMO/69846 |
|---|---|
| FullText URL | 79_6_437.pdf |
| Author | Matsumi, Junya| Sato, Tetsufumi| |
| Abstract | The optimal indications for intensive care unit (ICU) treatment for critically ill cancer survivors whose condition has deteriorated due to medical factors are unclear. To test our hypothesis that frailty before deterioration was associated with hospital mortality in this patient population, we retrospective analyzed the cases of the patients admitted to the ICU at the National Cancer Center Hospital, Japan (April 2014-March 2022). We excluded patients who underwent surgery within 28 days or were denied critical care within 24 h or admitted after cardiopulmonary arrest. Their Clinical Frailty Scale (CFS) scores at 1 month before ICU admission (Pre-ICU) were obtained. Frailty was defined as CFS scores ≥4 points. We analyzed 298 admissions and observed that the mortality rate at hospital discharge was significantly higher in the frailty group (n=119). A multivariate analysis demonstrated that the following factors were significantly associated with hospital mortality: Pre-ICU frailty (OR 2.00, 95%CI: 1.19-3.36, p=0.009), cancer type (hematological: OR 2.93, 95%CI: 1.42-6.05, p=0.004), and Sequential Organ Failure Assessment score at ICU admission (OR 0.88, 95%CI: 0.82-0.95, p=0.0008). Frailty retrospectively assessed using the CFS at 1 month pre-ICU admission is a risk factor for hospital mortality in these cancer survivors. |
| Keywords | frailty cancer survivor clinical frailty scale cancer critically ill |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 437 |
| End Page | 444 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443805 |
| Web of Science KeyUT | 001674277500005 |
| JaLCDOI | 10.18926/AMO/69845 |
|---|---|
| FullText URL | 79_6_431.pdf |
| Author | Inoue, Takahiro| Kuwabara, Hiroyo| Yamamoto, Koh| |
| Abstract | The effect of weekend admission on patient mortality has been investigated in several therapeutic areas, including acute myeloid leukemia (AML), but the investigations’ results are controversial. We evaluated the relationship between in-hospital mortality and weekend admission in adult patients with AML in Japan by conducting a retrospective observational study using administrative data from 144 acute care hospitals from which patients were discharged between April 2014 and March 2019. The primary endpoint was in-hospital mortality, compared between weekend and weekday admissions. Among the 1,340 eligible patients, 11% (150) were admitted during a weekend. The in-hospital mortality rates of the patients admitted during weekends and those admitted on a weekday were 28% (42/150) and 17% (204/1190), respectively. After an adjustment for covariates, weekend admission was associated with a significantly higher risk of in-hospital mortality than weekday admission (HR 1.70, 95%CI: 1.20-2.40; p=0.003). However, such an association was not observed in patients treated in a bio-clean room (HR 1.26, 95%CI: 0.65-2.42). Our results demonstrate that for patients with AML, weekend admission was independently associated with a higher risk of death during hospitalization. An appropriate system is necessary for these patients. |
| Keywords | acute leukemia weekend admission in-hospital mortality bio-clean room |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 431 |
| End Page | 436 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443804 |
| Web of Science KeyUT | 001674277500004 |
| JaLCDOI | 10.18926/AMO/69844 |
|---|---|
| FullText URL | 79_6_421.pdf |
| Author | Tanaka, Ayumi| Naoe, Shota| Takenaka, Reiju| Kanzaki, Norie| Sakoda, Akihiro| Yamaoka, Kiyonori| Kataoka, Takahiro| |
| Abstract | Radon (222Rn; Rn) and thoron (220Rn; Tn) inhalation have been reported to enhance antioxidant activity in various organs. However, the effects of Tn on the colon have not been investigated. This study aimed to clarify the effects of Tn inhalation, alone and in combination with cyclosporin A (CsA), on dextran sulfate sodium (DSS)-induced colitis, and the accompanying oxidative stress, in mice. Male BALB/c mice were subjected to continuous 8-day Tn inhalation (c-Tn, 533±128 Bq/m3) or alternate-day Tn inhalation over the same period (f-Tn, 577±63Bq/m3), followed by treatment with 3% DSS and either CsA or vehicle for 7 days. Although the disease activity index (DAI) decreased significantly by day 2 in the c-Tn group, scores remained significantly higher than those in the f-Tn group. In the c-Tn group, superoxide dismutase and catalase activity in the colon were significantly elevated compared with those in sham controls. Thus, DSS-induced damage was effectively inhibited in the earlier stages by the c-Tn mode of inhalation than by the f-Tn mode. These findings suggest that continuous Tn inhalation more effectively attenuated early colitis symptoms than alternate-day inhalation, potentially through upregulation of antioxidant defenses. Tn and CsA showed no combined effects. |
| Keywords | thoron DSS antioxidant activity CsA colon |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 421 |
| End Page | 429 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443803 |
| Web of Science KeyUT | 001674277500003 |
| JaLCDOI | 10.18926/AMO/69843 |
|---|---|
| FullText URL | 79_6_413.pdf |
| Author | Jiang, Zhiyun| Xi, Ying| |
| Abstract | Several observational studies suggested that migraine headache attacks were associated with coronavirus disease 2019 (COVID-19). We investigated genetic causal links between COVID-19 phenotypes and the development of headache and migraine, including migraine with aura (MA) and migraine without aura (MO). We conducted a two-sample Mendelian randomization (MR) analysis to estimate the genetic association in European populations. The inverse-variance weighted (IVW) method was used as the main approach in the MR analyses, together with weighted median and MR-Egger methods. We also performed a series of sensitivity tests to assess the robustness of the MR results. The MR results demonstrated that COVID-19 severity, hospitalization, and susceptibility had no causal effect on the risks of headache, migraine, MA, or MO. No horizontal pleiotropy was detected, and the results were robust as supported by the sensitivity analysis findings. Our analyses identified no casual effect of COVID-19 severity, hospitalization, or susceptibility on the risks of headache or migraine in European populations. |
| Keywords | headache migraine Mendelian randomization COVID-19 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 413 |
| End Page | 419 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443802 |
| Web of Science KeyUT | 001674277500002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hamada, Masanori| Nakata, Eiji| Nakahara, Ryuichi| Sugihara, Shinsuke| Katayama, Haruyoshi| Itano, Takuto| Inoue, Tomohiro| Takihira, Shota| Akezaki, Yoshiteru| Ozaki, Toshifumi| |
| Published Date | 2025-08-14 |
| Publication Title | PLoS One |
| Volume | volume20 |
| Issue | issue8 |
| Publisher | Public Library of Science |
| Start Page | e0328792 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Hamada et al. |
| File Version | publisher |
| PubMed ID | 40811154 |
| DOI | 10.1371/journal.pone.0328792 |
| Web of Science KeyUT | 001551423500023 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0328792 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Naomi| Matsuo, Rumi| Yamamura, Yuka| Tsuge, Takahiro| Kadowaki, Tomoka| Uraguchi, Kensuke| Tamai, Kei| Nakamura, Kazue| Takeuchi, Akihito| Yorifuji, Takashi| |
| Keywords | breastfeeding child health environmental exposure longitudinal studies perinatal |
| Published Date | 2025-01 |
| Publication Title | Pediatrics International |
| Volume | volume67 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | e70258 |
| ISSN | 1328-8067 |
| NCID | AA11320483 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 41215463 |
| DOI | 10.1111/ped.70258 |
| Web of Science KeyUT | 001611492800001 |
| Related Url | isVersionOf https://doi.org/10.1111/ped.70258 |
| JaLCDOI | 10.18926/AMO/69440 |
|---|---|
| FullText URL | 79_5_387.pdf |
| Author | Mori, Yusuke| Otani, Yoshihiro| Omae, Ryo| Hirano, Shuichiro| Ishida, Joji| Fujii, Kentaro| Haruma, Jun| Hiramatsu, Masafumi| Matsushita, Toshi| Higaki, Fumiyo| Sugiu, Kenji| Tanaka, Shota| |
| Abstract | Trigonal meningiomas are rare and pose surgical challenges due to their deep location and proximity to critical neuroanatomical structures. We present the case of a 67-year-old woman with a growing trigonal meningioma successfully resected with guidance by a preoperative 3D imaging analysis system. Integration of CT and MRI including diffusion tensor imaging (DTI) enabled precise mapping of the optic radiation, guiding a middle temporal gyrus approach. Preoperative embolization reduced tumor vascularity, facilitating gross total resection with minimal blood loss. This case highlights the effectiveness of preoperative 3D imaging systems in optimizing surgical planning and improving outcomes in complex neurosurgical cases. |
| Keywords | trigonal meningioma imaging analysis diffusion tensor imaging |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-10 |
| Volume | volume79 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 387 |
| End Page | 392 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41126470 |
| Web of Science KeyUT | 001606011100001 |
| JaLCDOI | 10.18926/AMO/69438 |
|---|---|
| FullText URL | 79_5_369.pdf |
| Author | Hisamatsu, Takashi| Kinuta, Minako| Munetomo, Sosuke| Fukuda, Mari| Kojima, Katsuhide| Taniguchi, Kaori| Nakahata, Noriko| Kanda, Hideyuki| |
| Abstract | We applied unsupervised machine learning to analyze blood pressure (BP) and resting heart rate (HR) patterns measured during a 1-year period to assess their cross-sectional relationships with subclinical cerebral and renal target damage. Dimension reduction via uniform manifold approximation and projection, followed by K-means++ clustering, was used to categorize 362 community-dwelling participants (mean age, 56.2 years; 54.9% women) into three groups: Low BP and Low HR (Lo-BP/Lo-HR), High BP and High HR (Hi-BP/Hi-HR), and Low BP and High HR (Lo-BP/Hi-HR). Cerebral vessel lesions were defined as the presence of at least one of the following magnetic resonance imaging findings: lacunar infarcts, white matter hyperintensities, cerebral microbleeds, or intracranial artery stenosis. A high urinary albumin-to-creatinine ratio (UACR) was defined as the top 10% (≥ 12 mg/g) of the mean value from ≥2 measurements. Poisson regression with robust error variance, adjusted for demographics, lifestyle, and medical history, showed that the Hi-BP/Hi-HR group had relative risks of 3.62 (95% confidence interval, 1.75-7.46) for cerebral vessel lesions and 3.58 (1.33-9.67) for high UACR, and the Lo-BP/Hi-HR group had a relative risk of 3.09 (1.12-8.57) for high UACR, compared with the Lo-BP/Lo-HR group. These findings demonstrate the utility of an unsupervised, data-driven approach for identifying physiological patterns associated with subclinical target organ damage. |
| Keywords | blood pressure heart rate subclinical disease uniform manifold approximation and projection unsupervised machine learning |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-10 |
| Volume | volume79 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 369 |
| End Page | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41126468 |
| Web of Science KeyUT | 001606013200007 |
