検索結果 - 岡山大学学術成果リポジトリ

Analysis of Phase Angle and Balance and Gait Functions in Pre-Frail Individuals: A Cross-Sectional Observational Study

JaLCDOI	10.18926/AMO/64357
フルテキストURL	77_1_21.pdf
著者	Homma, Daisuke\| Minato, Izumi\| Imai, Norio\| Miyasaka, Dai\| Sakai, Yoshinori\| Horigome, Yoji\| Suzuki, Hayato\| Dohmae, Yoichiro\| Endo, Naoto\|
抄録	We measured the muscle mass and phase angle of each body part to evaluate the relationship between balance and gait functions in individuals with a pre-frailty status. This cross-sectional observational study determined the skeletal muscle mass-to-body weight ratio and phase angles of 21 control (robust) and 29 pre-frail subjects. Their Brief-Balance Evaluation Systems Test, Timed Up-and-Go (TUG) test, Life-Space Assessment, and Modified Fall Efficacy Scale scores plus the relationship between muscle mass, phase angle, and motor function were evaluated. In the pre-frailty group (three males, 26 females, aged 75.58±7.60 years), significant correlations were noted between the Brief-Balance Evaluation Systems Test score and lower-limb (r=0.614) and wholebody (r=0.557) phase angles, and between the TUG test score and lower-limb muscle mass-to-body weight ratio (r=−0.616), lower-limb phase angle (r=−0.616), and whole-body phase angle (r=−0.527). Evaluating the phase angle of the lower extremities of pre-frail patients and intervening accordingly may help clinicians maintain and improve these patients’ balance and gait functions.
キーワード	bioelectrical impedance analysis motor function muscle quality muscle volume
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-02
巻	77巻
号	1号
出版者	Okayama University Medical School
開始ページ	21
終了ページ	27
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36849142
Web of Science KeyUT	000953663800003

Prevalence of Inducible Macrolide, Lincosamide, and Streptogramin B (inducible MLSB) Resistance in Clindamycin-Susceptible Staphylococcus aureus at Okayama University Hospital

JaLCDOI	10.18926/AMO/64355
フルテキストURL	77_1_1.pdf
著者	Nahar, Lutfun\| Hagiya, Hideharu\| Nada, Takahiro\| Iio, Koji\| Gotoh, Kazuyoshi\| Matsushita, Osamu\| Otsuka, Fumio\|
抄録	Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus. We here investigated the frequency and genotypic profiles of iMLSB resistance in clindamycin (CLDM)-susceptible S. aureus isolated in Okayama University Hospital from June 2020 to June 2021. We phenotypically screened the iMLSB resistance via D-zone test and performed PCR testing for the erythromycin ribosomal methylase (erm) genes: ermA and ermC. Among 432 CLDM-susceptible S. aureus isolates, 138 (31.9%) exhibited an iMLSB-resistance phenotype, with methicillinresistant S. aureus isolates (MRSA; 61 isolates: 58.6%) exhibiting higher positivity than methicillin-sensitive S. aureus isolates (MSSA; 77 isolates: 23.5%) (p<0.001). Male patients had a higher frequency of iMLSB resistance than females (OR [95%CI]: 1.8 [1.2-2.8]; p=0.007). Genotypically, ermA predominated in both MSSA (70.1%) and MRSA (86.9%) compared to ermC (14.3% in MSSA and 11.5% in MRSA). A single strain of MRSA possessed both ermA and ermC, while 12 (15.6%) MSSA isolates were negative for both ermA and ermC, suggesting the presence of other genetic mechanisms. Collectively, these results show that approximately 33% of CLDM-susceptible S. aureus isolates at our university hospital exhibited iMLSB resistance, predominantly caused by ermA in both MSSA and MRSA.
キーワード	antimicrobial resistance clindamycin erm D-zone test inducible MLSB
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-02
巻	77巻
号	1号
出版者	Okayama University Medical School
開始ページ	1
終了ページ	9
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36849140
Web of Science KeyUT	000953663800001

Surgical site infections in thyroid and parathyroid surgery in Japan: An analysis of the Japan Nosocomial Infections Surveillance database from 2013 to 2020

フルテキストURL	fulltext.pdf
著者	Iwatani, Tsuguo\| Saito, Shinya\|
キーワード	parathyroid surgery prophylactic antibiotic risk factor surgical site infection thyroid surgery
発行日	2022-12-11
出版物タイトル	International Wound Journal
巻	2022巻
出版者	Wiley
ISSN	1742-4801
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors.
論文のバージョン	publisher
PubMed ID	36504428
DOI	10.1111/iwj.14046
Web of Science KeyUT	000896886400001
関連URL	isVersionOf https://doi.org/10.1111/iwj.14046

The Beneficial Effect of Personalized Lifestyle Intervention in Chronic Kidney Disease Follow-Up Project for National Health Insurance Specific Health Checkup: A Five-Year Community-Based Cohort Study

フルテキストURL	fulltext.pdf
著者	Takeuchi, Hidemi\| Uchida, Haruhito A.\| Katayama, Katsuyoshi\| Matsuoka-Uchiyama, Natsumi\| Okamoto, Shugo\| Onishi, Yasuhiro\| Okuyama, Yuka\| Umebayashi, Ryoko\| Miyaji, Kodai\| Kai, Akiko\| Matsumoto, Izumi\| Taniguchi, Keiko\| Yamashita, Fukiko\| Emi, Tsutomu\| Sugiyama, Hitoshi\| Wada, Jun\|
キーワード	chronic kidney disease specific medical health check-up home-visit type lifestyle intervention CKD exacerbation
発行日	2022-10-26
出版物タイトル	Medicina
巻	58巻
号	11号
出版者	MDPI
開始ページ	1529
ISSN	1010-660X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	36363486
DOI	10.3390/medicina58111529
Web of Science KeyUT	000883971300001
関連URL	isVersionOf https://doi.org/10.3390/medicina58111529

Salvage Surgery for Symptomatic Recurrence of Retro-Odontoid Pseudotumor after a C1 Laminectomy

JaLCDOI	10.18926/AMO/64127
フルテキストURL	76_6_749.pdf
著者	Takami, Masanari\| Yukawa, Yasutsugu\| Noda, Yusuke\| Yoshida, Munehito\| Yamada, Hiroshi\|
抄録	We provide the first report of successful salvage surgery for a post-C1 laminectomy symptomatic recurrence of a retro-odontoid pseudotumor (ROP) that caused myelopathy. The 72-year-old Japanese woman presented with an ROP causing symptomatic cervical myelopathy. With ultrasonography support, we performed the enucleation of the ROP via a transdural approach and fusion surgery for the recurrence of the mass. At the final observation 2-year post-surgery, MRI demonstrated the mass’s regression and spinal cord decompression, and the patient’s symptoms had improved. Our strategy is an effective option for a symptomatic recurrence of ROP.
キーワード	recurrent retro-odontoid pseudotumor salvage surgery transdural resection C1 laminectomy ultra-sonography
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	749
終了ページ	754
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549779
Web of Science KeyUT	000905195100017

Posterolateral Floating Technique for the Thoracic Ossification of the Posterior Longitudinal Ligament with Navigation: A Technical Note

JaLCDOI	10.18926/AMO/64126
フルテキストURL	76_6_743.pdf
著者	Tanaka, Masato\| Suthar, Hardik\| Desai, Dhvanit\| Yamauchi, Taro\| Arataki, Shinya\| Fujiwara, Yoshihiro\| Uotani, Koji\| Oda, Yoshiaki\| Misawa, Haruo\|
抄録	We describe a floating technique via a posterolateral approach with intraoperative O-arm navigation to facilitate decompression of the spinal cord in thoracic myelopathy due to severe ossification of the posterior longitudinal ligament (OPLL). A 62-year-old man with myelopathy due to thoracic OPLL had left-leg muscle weakness, urinary disturbance, and spastic gait. Bilateral leg pain and gait disturbance had persisted for 2 years. He was successfully treated by the posterolateral OPLL floating procedure and posterior pedicle fixation under O-arm navigation. At a 2-year follow-up, manual muscle testing results and sensory function of the left leg had recovered fully. His cervical Japanese Orthopedic Association score had improved from 5/12 to 11/12. The novel intraoperative O-arm navigation-guided posterolateral floating procedure for thoracic OPLL is effective for achieving precise decompression and strong fixation with a posterior approach only and can provide an excellent result for severe thoracic OPLL without the risk of adverse events from intraoperative radiation.
キーワード	ossification of the posterior longitudinal ligament floating method navigation surgery C-arm free
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	743
終了ページ	748
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549778
Web of Science KeyUT	000905195100016

A Case of Paraplegia Treated with Cerebrospinal Fluid Drainage and Permissive Hypertension after Graft Replacement of the Ascending Aorta and the Total Aortic Arch for Acute Aortic Dissection Stanford Type A

JaLCDOI	10.18926/AMO/64125
フルテキストURL	76_6_737.pdf
著者	Yamaoka, Masakazu\| Yamamoto, Yumi\| Minami, Eriko\|
抄録	Paraplegia after an operation for acute aortic dissection Stanford type A (AADA) is fairly uncommon, and there is no consensus about optimal treatment. We present a case in which cerebrospinal fluid drainage (CSFD) and permissive hypertension were used for treatment of paraplegia. When the patient showed complete bilateral paraplegia after operation for AADA, we immediately began CSFD and maintained mean arterial blood pressure at over 90 mmHg. His neurological deficit gradually recovered, and he was eventually able to walk without support. The combination of CSFD and permissive hypertension could be a first-line emergent treatment for postoperative paraplegia after AADA surgery.
キーワード	paraplegia acute aortic dissection cerebrospinal drainage permissive hypertension
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	737
終了ページ	742
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549777
Web of Science KeyUT	000905195100015

The Impact of Tofogliflozin on Physiological and Hormonal Function, Serum Electrolytes, and Cardiac Diastolic Function in Elderly Japanese Patients with Type 2 Diabetes Mellitus

JaLCDOI	10.18926/AMO/64121
フルテキストURL	76_6_705.pdf
著者	Higashikawa, Toshihiro\| Ito, Tomohiko\| Mizuno, Takurou\| Ishigami, Keiichiro\| Kuroki, Kengo\| Maekawa, Naoto\| Usuda, Daisuke\| Izumida, Toshihide\| Yamada, Shinya\| Sangen, Ryusho\| Hamada, Kazu\| Kiyosawa, Jun\| Saito, Atsushi\| Iguchi, Masaharu\| Kasamaki, Yuji\| Nakahashi, Takeshi\| Fukuda, Akihiro\| Saito, Hitoshi\| Kanda, Tsugiyasu\| Okuro, Masashi\|
抄録	The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function.
キーワード	tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	705
終了ページ	713
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549773
Web of Science KeyUT	000905195100011

History of Transcatheter Arterial Chemoembolization Predicts the Efficacy of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients

JaLCDOI	10.18926/AMO/64120
フルテキストURL	76_6_695.pdf
著者	Onishi, Hideki\| Nouso, Kazuhiro\| Takaki, Akinobu\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Takeuchi, Yasuto\| Shiraha, Hidenori\| Okada, Hiroyuki\|
抄録	This study sought to identify factors that are predictive of a therapeutic response to hepatic arterial infusion chemotherapy (HAIC) by focusing on the number of prior transcatheter arterial chemoembolization (TACE) sessions. To determine the parameters predicting a good response to HAIC, we retrospectively analyzed 170 patients with hepatocellular carcinoma (HCC) who received HAIC regimens comprising low-dose cisplatin combined with 5-fluorouracil (LFP) or cisplatin (CDDP) for the first time. In both the LFP and CDDP regimens, the response rates were significantly lower in patients with three or more prior TACE sessions than in those with two or fewer prior TACE sessions (LFP 57% versus 28%; p=0.01, CDDP 27% versus 6%; p=0.01). Multivariable logistic regression analysis revealed that the number of prior TACE sessions (≥ 3) was significantly associated with non-responder status (odds ratio 4.17, 95% Confidence Interval (CI) 1.76-9.86) in addition to the HAIC regimen. Multivariable analysis using the Cox proportional hazards model revealed that a larger number of prior TACE sessions (≥ 3) was a significant risk factor for survival (hazard ratio 1.60, 95% CI 1.12-2.29) in addition to Child-Pugh class, serum alpha-fetoprotein concentration, and maximum diameter of HCC. HCC patients who receive fewer prior TACE sessions (≤ 2) were found to be better responders to HAIC.
キーワード	hepatic arterial infusion chemotherapy hepatocellular carcinoma refractory transcatheter arterial chemoembolization
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	695
終了ページ	703
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549772
Web of Science KeyUT	000905195100010

An Evaluation of the Efficacy of Compression Therapy Using Sleeves and Stockings to Prevent Docetaxel-induced Peripheral Neuropathy in Breast Cancer Patients

JaLCDOI	10.18926/AMO/64119
フルテキストURL	76_6_689.pdf
著者	Yamanouchi, Kosho\| Kuba, Sayaka\| Matsumoto, Megumi\| Yano, Hiroshi\| Morita, Michi\| Sakimura, Chika\| Otsubo, Ryota\| Hidaka, Masaaki\| Nagayasu, Takeshi\| Eguchi, Susumu\|
抄録	Taxanes are key drugs for patients with breast cancer. A major adverse effect of taxanes is peripheral neuropathy (PN). To investigate the ability of compression therapy using sleeves and stockings to prevent PN due to the taxane docetaxel, we conducted a single-center historical control trial. Patients receiving docetaxel at 75 mg/m2 every 3 weeks for 4 cycles as first-line chemotherapy for breast cancer were eligible. PN was evaluated using the common terminology criteria for adverse events version 4.0. The primary endpoint was the incidence of allgrade PN until 3 weeks after the fourth docetaxel administration. We evaluated 26 patients in the intervention group and compared their data to those collected retrospectively from 52 patients treated with docetaxel without compression. Neither the incidence of all-grade PN until 3 weeks after the fourth docetaxel administration (63.5% in the control group vs. 76.9% in the intervention group, p=0.31) nor that of PN grade ≥ 2 (13.5% vs. 15.4%, p=0.99) differed between the groups. In this study, the efficacy of compression therapy using sleeves and stockings to prevent PN induced by docetaxel was not demonstrated. Further clinical studies including medications or intervention are needed to reduce the incidence and severity of PN induced by chemotherapy.
キーワード	breast cancer docetaxel neuropathy compression
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	689
終了ページ	694
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549771
Web of Science KeyUT	000905195100009

Association of Genetic Polymorphism with Taxane-induced Peripheral Neuropathy: Sub-analysis of a Randomized Phase II Study to Determine the Optimal Dose of 3-week Cycle Nab-Paclitaxel in Metastatic Breast Cancer Patients

JaLCDOI	10.18926/AMO/64116
フルテキストURL	76_6_661.pdf
著者	Abe, Yuko\| Taira, Naruto\| Kashiwabara, Kosuke\| Tsurutani, Junji\| Kitada, Masahiro\| Takahashi, Masato\| Kato, Hiroaki\| Kikawa, Yuichiro\| Sakata, Eiko\| Naito, Yoichi\| Hasegawa, Yoshie\| Saito, Tsuyoshi\| Iwasa, Tsutomu\| Takashima, Tsutomu\| Aihara, Tomohiko\| Mukai, Hirofumi\| Hara, Fumikata\| Shien, Tadahiko\| Doihara, Hiroyoshi\| Toyooka, Shinichi\|
抄録	Chemotherapy-induced peripheral neuropathy (CIPN) is an important clinical challenge that threatens patients’ quality of life. This sub-study of the ABROAD trial investigated the influence of single nucleotide polymorphisms (SNPs) on CIPN, using genotype data from a randomized study to determine the optimal dose of a 3-week-cycle regimen of nab-paclitaxel (q3w nab-PTX) in patients with metastatic breast cancer (MBC). Patients with HER2-negative MBC were randomly assigned to three doses of q3w nab-PTX (SD: 260 mg/m2 vs. MD: 220 mg/m2 vs. LD: 180 mg/m2). Five SNPs (EPHA4-rs17348202, EPHA5-rs7349683, EPHA6-rs301927, LIMK2-rs5749248, and XKR4-rs4737264) were analyzed based on the results of a previous genome-wide association study. Per-allele SNP associations were assessed by a Cox regression to model the cumulative dose of nab-PTX up to the onset of severe or worsening sensory neuropathy. A total of 141 patients were enrolled in the parent study; 91(65%) were included in this sub-study. Worsening of CIPN was significantly greater in the cases with XKR4 AC compared to those with a homozygote AA (HR 1.86, 95%CI: 1.00001−3.46, p=0.049). There was no significant correlation of CIPN with any other SNP. A multivariate analysis showed that the cumulative dose of nab-PTX was most strongly correlated with CIPN (p<0.01).
キーワード	metastatic breast cancer taxane-induced peripheral neuropathy chemotherapy-induced peripheral neuropathy nab-paclitaxel single nucleotide polymorphism
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	661
終了ページ	671
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549768
Web of Science KeyUT	000905195100006

Fetal Cerebellar Growth Curves Based on Biomathematics in Normally Developing Japanese Fetuses and Fetuses with Trisomy 18

JaLCDOI	10.18926/AMO/64114
フルテキストURL	76_6_645.pdf
著者	Tada, Katsuhiko\| Miyagi, Yasunari\| Komatsu, Reina\| Okimoto, Naoki\| Tsukahara, Saya\| Tateishi, Yoko\| Ooka, Naomi\| Yoshida, Mizuho\| Kumazawa, Kazumasa\|
抄録	We used biomathematics to describe and compare cerebellar growth in normally developing and trisomy 18 Japanese fetuses. This retrospective study included 407 singleton pregnancies with fetuses at 14-39 weeks of gestation and 33 fetuses with trisomy 18 at 17-35 weeks. We used ultrasonography to measure fetal transverse cerebellar diameter (TCD) and anteroposterior cerebellar diameter (APCD). We hypothesized that cerebellar growth is proportional to cerebellar length at any given time point. We determined the formula L(t) ≒Keat+r, where e is Napier’s number, t is time, L is cerebellar length, and a, K, and r are constants. We then obtained regression functions for each TCD and APCD in all fetuses. The regression equations for TCD and APCD values in normal fetuses, expressed as exponential functions, were TCD(t)=27.85e0.02788t−28.62 (mm) (adjusted R2=0.997), and APCD(t)=324.29e0.00286t−322.62 (mm) (adjusted R2=0.995). These functions indicated that TCD and APCD grew at constant rates of 2.788%/week and 0.286%/week, respectively, throughout gestation. TCD (0.0153%/week) and APCD (0.000430%/week) grew more slowly in trisomy 18 fetuses. This study demonstrates the potential of biomathematics in clinical research and may aid in biological understanding of fetal cerebellar growth.
キーワード	biomathematics cerebellum fetus trisomy 18 syndrome ultrasonography
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	645
終了ページ	650
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549766
Web of Science KeyUT	000905195100004

Artificial Intelligence-based Detection of Epileptic Discharges from Pediatric Scalp Electroencephalograms: A Pilot Study

JaLCDOI	10.18926/AMO/64111
フルテキストURL	76_6_617.pdf
著者	Kobayashi, Katsuhiro\| Shibata, Takashi\| Tsuchiya, Hiroki\| Akiyama, Tomoyuki\|
抄録	We developed an artificial intelligence (AI) technique to identify epileptic discharges (spikes) in pediatric scalp electroencephalograms (EEGs). We built a convolutional neural network (CNN) model to automatically classify steep potential images into spikes and background activity. For the CNN model’ training and validation, we examined 100 children with spikes in EEGs and another 100 without spikes. A different group of 20 children with spikes and 20 without spikes were the actual test subjects. All subjects were ≥ 3 to < 18 years old. The accuracy, sensitivity, and specificity of the analysis were >0.97 when referential and combination EEG montages were used, and < 0.97 with a bipolar montage. The correct classification of background activity in individual patients was significantly better with a referential montage than with a bipolar montage (p=0.0107). Receiver operating characteristic curves yielded an area under the curve > 0.99, indicating high performance of the classification method. EEG patterns that interfered with correct classification included vertex sharp transients, sleep spindles, alpha rhythm, and low-amplitude ill-formed spikes in a run. Our results demonstrate that AI is a promising tool for automatically interpreting pediatric EEGs. Some avenues for improving the technique were also indicated by our findings.
キーワード	neural network deep learning electroencephalogram children spike
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	617
終了ページ	624
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549763
Web of Science KeyUT	000905195100001

Idiopathic Pneumonia Syndrome Refractory to Ruxolitinib after Post-Transplant Cyclophosphamide-based Haploidentical Hematopoietic Stem Cell Transplantation: Lung Pathological Findings from an Autopsy Case

JaLCDOI	10.18926/AMO/64044
フルテキストURL	76_5_609.pdf
著者	Matsumoto, Ken\| Fujishita, Keigo\| Matsuda, Masayuki\| Oka, Satoshi\| Fujisawa, Yuka\| Imai, Toshi\| Machida, Takuya\|
抄録	A 69-year-old Japanese man with acute leukemia received post-transplant cyclophosphamide-based haploidentical stem cell transplantation (PTCY-haplo-SCT) but was readmitted with dyspnea and ground-glass-opacities of the lungs. Bronchoscopy showed inflammatory changes with no signs of infection. He received steroids but required intubation as his condition deteriorated. In addition to antithymocyte globulin and cyclophosphamide, we administered ruxolitinib but failed to save him. Autopsy findings revealed fibrotic nonspecific interstitial pneumonia (NSIP) without evidence of organizing pneumonia or infection. Thus, we diagnosed idiopathic pneumonia syndrome (IPS). As far as our knowledge, this is the first case of IPS with NSIP histology after PTCY-haplo-SCT.
キーワード	idiopathic pneumonia syndrome ruxolitinib post-transplant cyclophosphamide-based haploidentical stem cell transplantation nonspecific interstitial pneumonia
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	609
終了ページ	615
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352810
Web of Science KeyUT	000884907100016

Surgical Resection for Local and Lateral Lymph Node Recurrence of MSI-high Cecal Cancer with the BRAF V600E Mutation

JaLCDOI	10.18926/AMO/64043
フルテキストURL	76_5_605.pdf
著者	Teraishi, Fuminori\| Jikuhara, Atsushi\| Ogawa, Ryunosuke\| Fujiwara, Toshiyoshi\|
抄録	An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation.
キーワード	BRAF V600E mutation cecal cancer, MSI-high
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	605
終了ページ	608
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352809
Web of Science KeyUT	000884907100015

Genital Feminizing Surgery without Vaginoplasty as a Safe, Aesthetic, and Cost-Effective Option for Gender-Affirming Surgery for Transwomen

JaLCDOI	10.18926/AMO/64042
フルテキストURL	76_5_597.pdf
著者	Watanabe, Shiho\| Watanabe, Toshiyuki\| Yamada, Kiyoshi\| Namba, Yuzaburo\| Kimata, Yoshihiro\|
抄録	Gender affirming surgery (GAS) has important impacts for people with gender incongruence (GI), both physically and socially. As the societal acceptance of gender diversity spreads, the number of individuals with GI who wish to be identified as the gender of their choice is increasing. Indeed, many elderly people who have lived a long time with GI now wish to undergo GAS, but face greater surgical risks due to greater burdens of underlying medical conditions. Generally, vaginoplasty is performed for transwomen; however, this surgery is time-consuming and involves heavy bleeding, and thus, should be avoided in elderly people. A less invasive technique is needed. In this article, we describe a new, less invasive genital feminizing surgical technique for transwomen with reports from two clinical cases. We present this novel technique as a safe, aesthetic, and cost-effective option for gender-affirming surgery for transwomen.
キーワード	gender-affirming surgery, vaginoplasty gender incongruence transwomen
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	597
終了ページ	603
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352808
Web of Science KeyUT	000884907100014

Surgery Outcomes for Pulmonary Metastases from Renal Cell Carcinoma

JaLCDOI	10.18926/AMO/64040
フルテキストURL	76_5_585.pdf
著者	Choshi, Haruki\| Watanabe, Mototsugu\| Furukawa, Shinichi\| Ujike, Hiroyuki\| Kataoka, Kazuhiko\|
抄録	Pulmonary metastatic resection is a standard therapy for renal cell carcinoma (RCC). Although patients with pulmonary metastases who do not undergo any treatment have poor prognoses, it has been reported that resection for pulmonary metastases yields good clinical outcomes. We investigated the prognoses of the 10 Japanese patients (eight males, two females) who underwent a surgical resection of pulmonary metastasectomy from RCC at our institution between April 1, 2012 and March 31, 2020 and analyzed the prognostic factors. We determined the prognoses and calculated the 5-year overall survival (OS) and disease-free survival (DFS) rates. To identify prognostic factors, we compared the median DFS duration for each factor. Elderly patients (median age, 75.5 years) were more predominant compared to previous studies, and all 10 patients underwent a complete resection. The 5-year DFS rate was 30.5% (95%CI: 0.045-0.63) and the 5-year OS rate was 80% (95%CI: 0.20-0.97). The following factors were associated with better prognosis: female, disease-free interval≥36 months, and metastases size<12 mm. These results indicate that complete resection for pulmonary metastases from RCC resulted in good clinical outcomes, particularly for patients with better prognostic factors.
キーワード	renal cell carcinoma pulmonary metastasis complete resection
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	585
終了ページ	591
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352806
Web of Science KeyUT	000884907100012

Hip Function Was Not Associated with the Incidence of Preoperative Deep Vein Thrombosis in Patients Undergoing Primary Total Hip Arthroplasty

JaLCDOI	10.18926/AMO/64039
フルテキストURL	76_5_577.pdf
著者	Okutani, Yuki\| Fujita, Hiroshi\| Harada, Hideto\| Kataoka, Masanao\| Murotani, Yoshiki\| Shimizu, Yu\|
抄録	The prevalence of preoperative deep vein thrombosis (DVT) has been reported to be relatively high in patients undergoing total hip arthroplasty. We investigated the prevalence of DVT, the association between hip function and preoperative DVT, and the effect of a history of surgery in patients who underwent primary total hip arthroplasty. We retrospectively analyzed the cases of the patients who underwent primary total hip arthroplasty between April 2013 and February 2020 at our institution. We evaluated the prevalence of preoperative DVT based on the results of the patients’ ultrasound screening. We performed univariate and multivariate analyses to investigate the association between the incidence of DVT and patient factors including age, sex, hip function, medical histories, and American Society of Anesthesiologists Physical Status classification. We analyzed 451 patients (494 hips). The prevalence of DVT was 14.2% (64 patients). The multivariate analysis demonstrated that increased age was an independent significant risk factor for DVT. The prevalence of preoperative DVT was relatively high among patients who underwent primary total hip arthroplasty. Preoperative DVT tended to be more prevalent in older patients. Hip function was not associated with the incidence of DVT.
キーワード	total hip arthroplasty deep vein thrombosis hip function ultrasound screening
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	577
終了ページ	584
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352805
Web of Science KeyUT	000884907100011

Correlation between Mean Arterial Pressure and Regional Cerebral Oxygen Saturation on Cardiopulmonary Bypass in Pediatric Cardiac Surgery

JaLCDOI	10.18926/AMO/64037
フルテキストURL	76_5_557.pdf
著者	Pan, Yu\| Song, Qingqing\| Kanazawa, Tomoyuki\| Morimatsu, Hiroshi\|
抄録	Some pediatric cardiac patients might experience low regional cerebral oxygen saturation (rSO2) during surgery. We investigated whether a pediatric patient’s mean arterial pressure (MAP) can affect the rSO2 value during cardiopulmonary bypass (CPB). We retrospectively analyzed the cases of the pediatric patients who underwentcardiac surgery at our hospital (Jan. –Dec. 2019; n=141). At each MAP stage, we constructed line charts through the mean of the rSO2 values corresponding to each MAP and then calculated the correlation coefficients. We next divided the patients into age subgroups (neonates, infants, children) and into cyanotic congenital heart disease (CHD) and acyanotic CHD groups and analyzed these groups in the same way. The analyses of all 141 patients revealed that during CPB the rSO2 value increased with an increase in MAP (r=0.1626). There was a correlation between rSO2 and MAP in the children (r=0.2720) but not in the neonates (r=0.06626) or infants (r=0.05260). Cyanotic CHD or acyanotic CHD did not have a significant effect on the rSO2/MAP correlation. Our analysis demonstrated different patterns of a correlation between MAP and rSO2 in pediatric cardiac surgery patients, depending on age. MAP was positively correlated with rSO2 typically in children but not in neonate or infant patients.
キーワード	mean arterial pressure cerebral oxygen saturation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	557
終了ページ	564
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352803
Web of Science KeyUT	000884907100009

Psychological Stress Induced by Prone Positioning among Adults with Severe Cerebral Palsy

JaLCDOI	10.18926/AMO/64034
フルテキストURL	76_5_535.pdf
著者	Matsuda, Tadashi\| Akezaki, Yoshiteru\| Tsuji, Yoko\| Hamada, Kazunori\| Ookura, Mitsuhiro\|
抄録	The purpose of this study was to investigate the psychological impact of various positionings in subjects with cerebral palsy (CP). The participants were 17 individuals with severe motor and intellectual disability due to CP. They began in a sitting position in their wheelchair, and were placed consecutively in prone or supine positions, with no intervals between placements. Physiological observations were made in each position, and included salivary α-amylase activity, pulse, percutaneous oxygen saturation, respiratory rate, learance or not of airway secretions, and occurrence or not of adverse events. Salivary α-amylase activity values were higher in the prone position than in the baseline and supine positions (p<0.05). Clearance of airway secretions was significantly more prevalent in the prone position than in the baseline and supine positions (p <0.05). The participants’ pulse was significantly lower in the supine and prone positions than in the baseline position (p<0.05). Greater prevalence of airway secretion clearance and significantly higher stress levels as indicated by saliva amylase were observed in the prone position than in the other two positions. Therefore, when such patients are placed in a prone position, close attention to airway management and the potential for psychological stress may be necessary.
キーワード	alpha-amylase stress positioning cerebral palsy severe motor and intellectual disability
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	535
終了ページ	540
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352800
Web of Science KeyUT	000884907100006