検索結果 - 岡山大学学術成果リポジトリ

Difference in motility of basophilic, granulocytes from atopic subjects following antigen- and Ca inophore A23187-stimulation

JaLCDOI	10.18926/15311
タイトル（別表記）	抗原および Ca ionophore A23187 刺激時におけるアトピー型気管支喘息末梢血好塩基球の運動能
フルテキストURL	064_043_051.pdf
著者	谷崎勝朗\| 貴谷光\| 御船尚志\| 光延文裕\| 越智浩二\| 原田英雄\| 中川二郎\| 宗田良\| 高橋清\| 木村郁郎\|
抄録	We examined histamine release and morphological changes in basophilic granulocytes from atopic subjects, in response to stimulation with antigen and Ca ionophore A23187. 1. Histamine release and a reduction in the rumber of basophils were more rapid and greater in extent at an early stage of antigen stimulation compared with Ca ionophore A23187 stimulation. 2. Morphological changes in basophils, represented by increased motility, in terms of an increased ratio of short to long axis diameter (L/S ratio), as well as the increased frequency of basophils with localized granules and those with pseudopods, were more often observed antigen stimulation than with Ca ionophore A23187 stimulation. In contrast, morphogical changes in which basophils appeared swollen, showing an increased mean cell diameter and an increased frequency of cells with 5 vacuoles or more were more predominant with Ca ionophore A23187 than with antigen stimulation. The results obtained here show that bridging of IgE receptors is essential to activate basophils and induce increased motility in these cells.
キーワード	histamine release (ヒスタミン遊離) increased basophil motility (好塩基球の運動能の亢進) bridging of IgE receptors (LgE 受容体) antigen (抗原) Ca ionophore A23187
出版物タイトル	岡大三朝分院研究報告
発行日	1993-06
巻	64巻
開始ページ	43
終了ページ	51
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002307677

Characteristics of humoral and cellular factors participating in onset mechanism of asthma in　relation to clinical types classified by symptoms.

JaLCDOI	10.18926/15310
タイトル（別表記）	気管支喘息の臨床分類とその細胞性および液性因子の特徴
フルテキストURL	064_036_042.pdf
著者	谷崎勝朗\| 貴谷光\| 御船尚志\| 光延文裕\| 梶本和宏\| 杉本啓介\| 横田聡\| 平松順一\| 瓦屋正志\| 中桐善康\| 多田慎也\| 木村郁郎\|
抄録	Characteristics of each asthma type classified by clinical symptoms and　findings were studied in 72 patients with bronchial asthma. 1. Ventilatory function tests showed that the values of % MMF, % V(50) and % V(25) were significantly lower in patients with bronchiolar obstruction (type II) compared to the values of those with simple bronchoconstriction type (type Ia) and those with bronchoconstriction + hypersecretion (type Ib). 2. The proportion of neutrophils in bronchoalveolar lavage (BAL) fluid was significantly higher in type II than in type Ia and type Ib. Several　patients with type Ib showed higher proportion of BAL eosinophils. 3. The release of LTC(4) from leucocytes was significantly lower in type II compared with type Ia and type Ib. There was no significant difference in the release of histamine and LTB(4) among the three asthma types.
キーワード	Bronchial asthma Asthma classification BAL fluid chemical mediators
出版物タイトル	岡大三朝分院研究報告
発行日	1993-06
巻	64巻
開始ページ	36
終了ページ	42
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002307662

Humoral and cellular immune response in elderly patients with bronchial asthma

JaLCDOI	10.18926/15308
タイトル（別表記）	老年者気管支喘息における液性および細胞性免疫反応について
フルテキストURL	064_075_082.pdf
著者	谷崎勝朗\| 貴谷光\| 御船尚志\| 光延文裕\| 梶本和宏\| 杉本啓介\| 横田聡\| 平松順一\| 瓦屋正志\| 越智浩二\| 原田英雄\| 多田慎也\| 木村郁郎\|
抄録	Humoral and cellular immune responses in bronchial asthma were examined by comparing the results of older asthmatics (group OA) with those of older healthy subjects (group OH) and of younger asthmatics (group YA). In humoral immune response, IgE-mediated immune system expressed by elevated serum IgE levels and IgE antibodies for house dust mite (HDm) and/or Candida albicans was clearly found in older asthmatics, while there was no finding showing the presence of IgE-mediated immune response in older healthy subjects. There was no significant difference in levels of serum IgG and IgA among the three groups. However, the serum IgM level was significantly lower in older asthmatics than in younger asthmatics. IgE antibodies to HDm and/or Candida albicans were more frequently found in older asthmatics compared with older healthy subjects. In contrast, IgG(4) antibodies to HDm were not different among the three groups. IgG(4) antibodies to Candida albicans were significantly higher in both older groups than in younger group. However, there was no significant difference between asthmatic and healthy subjects in the elderly. Delayed skin reaction to PPD was significantly more decreased in older asthmatics. These results show that bronchial asthma in the elderly is characterized by the presence of IgE-mediated immune response and by the changes of immune response with aging.
キーワード	IgE IgG(4) Immunoglobulings (免疫グロブリン) PPD Bronchial asthma (気管支喘息) 加齢
出版物タイトル	岡大三朝分院研究報告
発行日	1993-06
巻	64巻
開始ページ	75
終了ページ	82
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002307261

House dust mite allergy in patients with　bronchial asthma. Serum IgE levels and IgE antibody values in relation to patient age.

JaLCDOI	10.18926/15307
タイトル（別表記）	気管支喘息におけるハウスダストアレルギー. 血清IgE値とIgE抗体価と年齢との関連
フルテキストURL	064_031_035.pdf
著者	谷崎勝朗\| 貴谷光\| 御船尚志\| 光延文裕\| 梶本和宏\| 杉本啓介\| 横田聡\| 平松順一\| 越智浩二\| 原田英雄\| 多田慎也\| 木村郁郎\|
抄録	Serum IgE levels and IgE antibody values in relation to patient age were examined in 50 patients with house dust mite (HDm) sensitive asthma, 1. IgE antibody values to HDm were highest in patients between the ages of 10 and 19, and the　values generally low in those over the age of 40. 2. High IgE antibody values to HDm　were accompanied by high serum IgE levels in patients between 10 and 19. IgE antibody values and serum IgE levels were in general low in patients over age 40. In patient under　age 9, serum IgE levels were less than 500 IU/ml in 5 of the 10 subjects despite an increased value of IgE antibodies to HDm. These results suggest that an increased　production of IgE antibodies to HDm is usually accompanied by an increased production of total IgE in younger subjects. However, an increase in production of IgE antibodies is not always related to an increase in production of total IgE in patients under age 9. The results also show that production of IgE antibodies to HDm and total IgE is in general low in older patients despite the hyperreactivity to HDm.
キーワード	Serum IgE (血清IgE) IgE antibodies (IgE抗体) house dust mite (ダニ) bronchial asthma (気管支喘息)
出版物タイトル	岡大三朝分院研究報告
発行日	1993-06
巻	64巻
開始ページ	31
終了ページ	35
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002307674

Neutrophils in the airways of patients with bronchial asthma. Relationship to ventilatory function

JaLCDOI	10.18926/15306
タイトル（別表記）	気管支喘息における気道内への好中球の出現とその意義　換気機能と関連して
フルテキストURL	063_025_029.pdf
著者	谷崎勝朗\| 貴谷光\| 岡崎守宏\| 御舩尚志\| 光延文裕\| 谷水将邦\| 本家尚子\| 草浦康浩\| 木村郁郎\|
抄録	Ventilatory function was compared between two age-matched asthma groups : group A (study group) consists of 8 patients with bronchial asthma with marked neutrophilia (20% or more) in the BAL fluid and group B (control group) of 8 patients with neutrophils (less than 5% of total BAL cells). The values of six ventilatory parameters were lower in group A than in group B, and a significant difference was found in FEV(1.0%), % MMF, % V(50) and % V(25) between groups A and B. Of these parameters, the value of % V(25) was markedly decreased in group A compared with group B. The results show that ventilatory dysfunction in airways, especially in small airways, is closely correlated to increased number of neutrophils in BAL fluid.
キーワード	ventilatory function (換気機能) neutrophils in BAL fluid (好中球, BAL) small airways (細気管支) bronchial asthma (気管支喘息)
出版物タイトル	岡大三朝分院研究報告
発行日	1992-06
巻	63巻
開始ページ	25
終了ページ	29
ISSN	0913-3771
言語	英語
論文のバージョン	publisher
NAID	120002307993

Clinical significance of airway inflammation in bronchcial asthma. Comparison with chronic obstructive bronchiolitis.

JaLCDOI	10.18926/15305
タイトル（別表記）	気管支喘息における気道炎症反応の臨床的意義｡慢性閉塞性細気管支炎との比較検討
フルテキストURL	064_024_030.pdf
著者	谷崎勝朗\| 貴谷光\| 御船尚志\| 光延文裕\| 梶本和宏\| 杉本啓介\| 横田聡\| 平松順一\| 瓦屋正志\| 越智浩二\| 原田英雄\| 多田慎也\| 木村郁郎\|
抄録	Clinical significanoce of airway inflammation was assessed in 28 patients with bronchial asthma, and the results were compared with those in 9 patients with chronic obstructive bronchiolitis (COB). 1. Total cell number in bronchoalveolar lavage(BAL) fluid was markedly increased in patients with COB (51.0×10(6)), which was significantly greater than that in those with bronchial asthma (9.6×10(6) ). 2. The proportion of BAL macrophages was significantly higher in patients with bronchial asthma than in those with COB. However, the, absolute number of BAL macrophages was not significantly different between them. 3. The proportion of BAL lymphocytes was higher in patients with bronchial asthma than in those with COB, but this difference was not signifcant. In contrast, the absolute number of BAL lymphocytes was significantly greater in patients with COB than in those with bronchial asthma. 4. The proportion and the number of BAL neutrophils were markedly increased in patients with COB compared to those with bronchial asthma. 5. The proportion and the number of BAL eosinophils were higher in patients with bronchial asthma than in those with COB, although these defferences were not significant. The results suggest that airway inflammation in bronchial asthma is not so intensive as that in COB.
キーワード	airway inflammation (気道炎症反応) bronchial asthma (気管支喘息) chronic obstructive bronchiolitis (慢性閉塞性細気管支炎) lymphocytes (リンパ球) neutrophils (好中球)
出版物タイトル	岡大三朝分院研究報告
発行日	1993-06
巻	64巻
開始ページ	24
終了ページ	30
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002307730

Role of eosinophils in the airways of patients with atopic asthma. Relationship to mucus hypersecretion

JaLCDOI	10.18926/15304
タイトル（別表記）	気管支喘息における気道内への好酸球の出現とその意義. 過分泌と関連して.
フルテキストURL	063_014_018.pdf
著者	谷崎勝朗\| 貴谷光\| 岡崎守宏\| 御舩尚志\| 光延文裕\| 木村郁郎\|
抄録	A correlation between the proportion of eosinophils in bronochoalveolar lavage (BAL) fluid and amount of expectoration was examined in patients with atopic asthma. The subjects were divided into two groups : cases with high proportion (20% of more) (group A) and low proportion (less than 5%) (group B) of eosinophils in the BAL fluid. Any significant difference was not paesent in the value of each ventilatory parameter between the two groups. The amount of expectoration/day was significantly higher in group A compared with group B (p<0.001). These results suggest that eosinophilia in BAL fluid correlates to mucus hypersecretion in the airways of patients with atopic asthma.
キーワード	Eosinophilia (好酸球) Hypersecretion (過分泌) BAL fluid (BAL) bronchial asthma (気管支喘息)
出版物タイトル	岡大三朝分院研究報告
発行日	1992-06
巻	63巻
開始ページ	14
終了ページ	18
ISSN	0913-3771
言語	英語
論文のバージョン	publisher
NAID	120002307156

Activated blood T cells in patients with bronchial asthma. Relationship to asthmatic cycle.

JaLCDOI	10.18926/15303
タイトル（別表記）	気管支喘息におけるActivated Tリンパ球について,喘息発作との関連
フルテキストURL	064_011_016.pdf
著者	谷崎勝朗\| 貴谷光\| 御船尚志\| 光延文裕\| 梶本和宏\| 杉本啓介\| 横田聡\| 平松順一\| 瓦屋正志\| 原田英雄\| 多田慎也\| 木村郁郎\|
抄録	The number of CD4(+) T-Iymphocytes, CD4/CD8 ratio, and the number of IL2R(+) T-Iymphocytes (CD25) were examined in 14 patients with bronchial asthma, and the results were compared in three different asthma stages : symptom-free stage, wheeze stage, and attack stage. 1. The proportion of blood CD4(+) T-lymphocytes was more decreased in patients with asthma attacks than in those without symptoms. The CD4/CD8 ratio was also more　decreased in patients with attacks than in those without symptoms. However, these differences were not significant. 2. The proportion of blood activated T cells (IL2R(+) cells, CD25) was significantly increased in patients with attacks than in those without symptoms. The proportion of activated T cells in 5 asthma patients was 2.9±0.8% in　symptom-free stage and 6.6±1.1% in attack stage(p<0.001). These findings show that numbers of activated T-lymphocytes in peripheral blood were increased during asthma attacks, and this increase suggests the participation of　activated T cells in the pathogenesis of asthma.
キーワード	CD4(+) T cells (CD4(+)リンパ球) CD4／CD8 ratio (CD4／CD8比) IL2R(+) T cells (IL2R(+)Tリンパ球) bronchial asthma (気管支喘息)
出版物タイトル	岡大三朝分院研究報告
発行日	1993-06
巻	64巻
開始ページ	11
終了ページ	16
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002307394

Lymphocytes in the airways of patients with bronchial asthma. Is there any relationship to IgE-mediated allergic reaction.

JaLCDOI	10.18926/15302
タイトル（別表記）	気管支喘息における気道内リンパ球の出現とその意義.IgE系反応との関連について.
フルテキストURL	063_019_024.pdf
著者	谷崎勝朗\| 貴谷光\| 岡崎守宏\| 御舩尚志\| 光延文裕\| 谷水将邦\| 本家尚子\| 草浦康浩\| 木村郁郎\|
抄録	Relationship of the proportion of lymphocytes in　bronchoalveolar lavage (BAL) fiutd to IgE-mediated reactions and to ventilatory function was studied in two age-matched asthma groups : group A of 11 subjects with BAL lymphocytes over 30% and group B of 11 subjects with BAL leyphocytes less than 10%. Of the eleven subjects in group A, 3 (27.3%) were atopic and 4 (36.4%) were non-atopic. The proportion of BAL lymphocytes in subjects with serum IgE level more than 300 IU/ml, who were all older than 50 years, was significantly higher than that in subjects with serum IgE less than 100 IU/ml in group A (p<0.05). While of the eleven subjects of group B, 5 (45.5%) were atopic and 4 (36.4%) were non-atopic. The value of % V(25) was significantly higher in the atopics compared with the non-atopics in group A (p<0.05), although no significant difference was found in the value of % V(25) between the two asthma types in group B. The results show that an increased number of lymphocytes in BAL fluid may be enhanced by IgE-mediated allergic reactions in the elderly, and that the decreased value of % V(25) may be associated withan increased number of lymphocytes in BAL fluid in non-atopics.
キーワード	Lymphocytes (リンパ球) BAL fluid (BAL液) IgE antibody (IgE抗体) bronchial asthma (気管支喘息)
出版物タイトル	岡大三朝分院研究報告
発行日	1992-06
巻	63巻
開始ページ	19
終了ページ	24
ISSN	0913-3771
言語	英語
論文のバージョン	publisher
NAID	120002307202

Immunosuppression by glucocorticoids leads to bronchoalveolar neutrophilia in patients with bronchial asthma

JaLCDOI	10.18926/15301
タイトル（別表記）	気管支喘息における副腎皮質ホルモン長期投与による免疫抑制と気管支肺胞洗浄液中好中球増多との関連
フルテキストURL	064_017_023.pdf
著者	谷崎勝朗\| 貴谷光\| 御船尚志\| 光延文裕\| 梶本和宏\| 杉本啓介\| 横田聡\| 平松順一\| 瓦屋正志\| 原田英雄\| 木村郁郎\|
抄録	Cellular composition of bronchoalveolar lavage (BAL) fluid was compared　between two age-matched steroid-dependent　intractable asthma (SDIA) groups : 17 group A patients (serum IgG level < 1000mg/dℓ) whose immunity was regarded as being　suppressed by long-term glucocorticoid therapy and 17 group B patients (serum IgG level > 1200mg/dℓ). 1. The levels of serum IgA and IgM were significantly decreased in group A compared to the levels in group B patients. 2. The number of blood lymphocytes was also significantly lower in group A than in group B patients. However, the number of blood neutrophils was not different between the two asthma groups. 3.The number of BAL lymphocytes was significantly lower in group A than in group B patients. 4. BAL neutrophilia (more than 1.5×10 (4)/mℓ) was observed in 6 of the 17(35.3%) patients in group A, but not observed in any patients in group B. The number of BAL neutrophils was significantly greater in group A than in group B　patients. These results suggest that there is a correlation between immunosuppression by glucocorticoids and BAL neutrophilia in patients with bronchial asthma.
キーワード	immunosuppression (免疫抑制) BAL neutrophilia (BAL好中球増多) glucocorticoids (副腎皮質ホルモン) bronchial asthma (気管支喘息)
出版物タイトル	岡大三朝分院研究報告
発行日	1993-06
巻	64巻
開始ページ	17
終了ページ	23
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002307882

Spa therapy is very important for the treatment of steroid-dependent intractable asthma (SDIA). Analysis of 181 patients with SDIA.

JaLCDOI	10.18926/15299
タイトル（別表記）	ステロイド依存性重症難治性喘息に対する温泉療法の重要性｡過去10年間の181例を対象に。
フルテキストURL	064_001_010.pdf
著者	谷崎勝朗\| 貴谷光\| 御船尚志\| 光延文裕\| 梶本和宏\| 杉本啓介\| 横田聡\| 平松順一\| 瓦屋正志\| 越智浩二\| 原田英雄\| 多田慎也\| 木村郁郎\|
抄録	Characteristics of 181 patients with steroid-dependent intractable asthma (SDIA) who were admitted to our hospital and had spa therapy for last 10 years were examined in relation to the methods of spa therapy. For last 10 years, three kinds ofspa therapies were administered: spa therapy A (swimming training in a hot spring pool) in the first atage (1982-1985), spa therapy B (swimming training + inhalation of iodine salt solution) in the middle stage (1986 -1989), and spa therapy C (swimming training + inhalation of iodine salt solution + fango therapy) in the last stage (1990-1991) of this study. 1. The number of patients with SDIA who were admitted to our hospital and had spa therapy tended to increase from 2 in 1986 to 35 in 1991. 2. The number of SDIA patients over the age of 60 or over the age at onset of 40 tended to increase from the first stage to the last stage. 3. The proportion of patients from distant areas (prefectures other than Tottori) was decreasing for the last stage, although the number of these patients was increasing in recent years. 4. The proportions of patients divided by serum IgE levels and by clinical asthma types did not change for last 10 years. 5. The proportion of type Ib and type II asthma was considerably high in patients with SDIA for last 10 years. 6. Clinical effects of spa therapy were observed in 21 of the 30 (70.0%)patients with SDIA in the first stage (1982-1985) with spa therapy A, 68 of the 83 (74.7%) patients with SDIA in the middle stage (1986-1989) with spa therapy B, and 61 of the 68 (89.7%) patients with SDIA in the last stage (1990-1991) with spa therapy C.
キーワード	swimming training in a hot spring pool (温泉プール水泳訓練) inhalation of iodine salt solution (ヨードゾル吸入) fango therapy (鉱泥湿布療法) SDIA
出版物タイトル	岡大三朝分院研究報告
発行日	1993-06
巻	64巻
開始ページ	1
終了ページ	10
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002307391

Action mechanisms of complex spa therapy on steroid-dependent asthma

JaLCDOI	10.18926/15298
タイトル（別表記）	ステロイド依存性重症難治性喘息に対する複合温泉療法の作用機序
フルテキストURL	063_001_006.pdf
著者	谷崎勝朗\| 貴谷光\| 岡崎守宏\| 御船尚志\| 光延文裕\| 高取明正\| 奥田博之\| 越智浩二\| 原田英雄\| 木村郁郎\|
抄録	Effects of complex spa therapy, which comprises swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy, were analyzed in patients with steroid-dependent intractable asthma (SDIA) by comparison between the subjects with and without efficacy of the therapy. 1. The complex spa therapy was effective in the patients with lower levels of FEV(1.0%) and % PEFR. 2. The complex spa therapy was not always effective in the patients with a low value of % V(25), which represents depressed airflow in the small airways. 3. The efficacy of the complex spa therapy was found in the patients showing a low value of % V(25) accompanied by BAL neutrophilia, but not found in those without increased proportion (more than 10% ) of neutrophils in BAL fluid. The results reveal that the complex spa therapy is effective in patients with SDIA showing low values of FEV(1.0%) and % PEFR, and in those with a low value of % V(25) and BAL neutrophilia.
キーワード	complex spa therapy (複合温泉療法) ventilatory function　(換気機能) BAL neutrophilia　(BAL好中球増多) bronchial asthma (気管支喘息)
出版物タイトル	岡大三朝分院研究報告
発行日	1992-06
巻	63巻
開始ページ	1
終了ページ	6
ISSN	0913-3771
言語	英語
論文のバージョン	publisher
NAID	120002307537

Inspection Method by Comparing CAD Figure with Processed Image

JaLCDOI	10.18926/15297
フルテキストURL	Mem_Fac_Eng_OU_33_2_97.pdf
著者	神代充\| 大崎紘一\| 梶原康博\| 宗澤良臣\| Tano Masakazu\| Okamoto Katsuyuki\| Nishino Akira\| Okamoto Asao\| Nishimori Naoki\|
抄録	We propose the recognition method of bridge soldering base metal on the circuits by comparing CAD figure and input image of image processing to locate the soldering iron tip accurately to secure the high quality Firstly, three dimensional CAD assembly drawing of circuits which are assembled perpendicularly in each other is projected on an imaginary two dimensional screen which is vertical to the optical axis of the camera The projected image is used as the standard CAD figure to inspect the location of the bridge soldering base metal. The positions among the bridge soldering base metals show the line state. So this line (connecting line) is used as the reference line to inspect the location of the bridge soldering base metal. The characteristics of the standard figure are represented by the connecting line, edge line and center points of base metal. Secondly, the position and gradient of connecting line among bridge soldering base metals in the input image is estimated. And the position of base metal and assembly accuracy of circuit units are calculated by comparing the shape and position of each base metal with its standard figure based on the connecting line Furthermore, the length between the opposite edges of the base metals are calculated to inspect the positions and the assemble accuracy of circuit units.
出版物タイトル	Memoirs of the Faculty of Engineering, Okayama University
発行日	1999-04-27
巻	33巻
号	2号
開始ページ	97
終了ページ	103
ISSN	0475-0071
言語	英語
論文のバージョン	publisher
NAID	120002307283

Extracellular matrix components and soluble VCAM-1 in synovial fluid with osteoarthritis of the knee

JaLCDOI	10.18926/15289
タイトル（別表記）	変形性膝関節炎患者膝関節液中の細胞外マトリックス成分と可溶性VCAM-1
フルテキストURL	007_2_099_103.pdf
著者	唐下博子\| 一村光子\| 崎山順子\| 岡本基\| 中田安成\| 遠藤浩\|
抄録	It is generally accepted that the number of patients with osteoarthritis (OA) of the knee must increase in the future because of the increase of the aged. The pathogenic mechanisms of OA haven't been elucidated yet, but it is supposed that mediate pannus may cause the factors for irreversible cartilage damage in the inflammatory process. Therefore it is very important to find and predict OA at the early stage. Now there were many indices to determine joint damage with OA, for example, cytokines including IL, TNF, TGF, matrix metalloproteinase (MMPs), tissue inhibitor of metalloproteinase (TIMPs), proteoglycan (PG), hyaluronate (HA), super oxide, adhesion molecules including, ICAM-1, VCAM-1 and PECAM. In this study, we measured that the soluble VCAM-1 (sVCAM-1), soluble collagen (sCOLL), heparansulfate proteoglycan (HSPG), uronic acis and CRP in synovial fluids (SF) with OA. A positive correlation between the level of sVCAM-1 and sCOLL (ρ = 0.652) was noted. However there was no factor showing a correlation with CRP. It was suggested that the levels of sVCAM-1 and sCOLL in the synovia fluid were active inflammation indices of knee damage, as the different aspects from CRP. The level of HSPG also showed a unique trend because HSPG on the cell surface was quickly digested endocytosis, so that it was not suitable for the inflammatory index in synovial fluid with OA.
キーワード	変形性膝関節炎 (Osteoarthritis) 細胞外マトリックス (Extracellular matrix) 可溶性VCAM-1 (Soluble VCAM-1) 可溶性コラーゲン (Soluble Collagen) 可溶性ヘパラン硫酸プロテオグリカン (Soluble HSPG)
出版物タイトル	岡山大学医療技術短期大学部紀要
発行日	1997-01-31
巻	7巻
号	2号
開始ページ	99
終了ページ	103
ISSN	0917-4494
言語	英語
論文のバージョン	publisher
NAID	120002307341

Diagnostic method for induction motor using simplified motor simulator

JaLCDOI	10.18926/15269
フルテキストURL	Mem_Fac_Eng_OU_35_47.pdf
著者	堂前行宏\| 小西正躬\| 今井純\| Asada, Hideki\| Kitamura, Akira\|
抄録	In this paper, an identification method of motor parameters for the diagnosis of rotor bar defects in the squirrel cage induction motor is proposed. It is difficult to distinguish the degree of deterioration by a conventional diagnostic method such as Fourier analysis. To overcome the difficulty, a motor simulator is used to identify the degree of deterioration of rotors in the squirrel cage induction motor. Using this method, the deterioration of rotor bars in the motor can be estimated quantitatively.
出版物タイトル	Memoirs of the Faculty of Engineering, Okayama University
発行日	2001-03-27
巻	35巻
号	1-2号
開始ページ	47
終了ページ	51
ISSN	0475-0071
言語	英語
論文のバージョン	publisher
NAID	120002307181

Human serum lipoprotein-cyclodextrin interaction in agarose gel

JaLCDOI	10.18926/15268
タイトル（別表記）	ヒト血清リポタンパク質とシクロデキストリンのアガロースゲル内における相互作用
フルテキストURL	007_2_093_097.pdf
著者	一村光子\| 唐下博子\| 崎山順子\| 森秀治\| 伊藤昔子\| 中田安成\| 遠藤浩\|
抄録	Cyclodextrins (CDs) are cyclic oligosaccharides with low molecular weight. They have been known to bind to some serum lipoproteins and to form complexes. To elucidate whether each serum lipoprotein subclass could be separated by electrophoresis using CDs, we performed preliminary experiment, in which lipoprotein-CDs interaction was examined on electrophoresis with agarose gel. When the supporting agarose gel containing both α-CD and β-CD was prepared and was applied to isoelectric focusing for fractionating serum lipoproteins, apoB lipoproteins were found to be clearly separated into several fractions on this electrophoresis. This finding suggested that apoB lipoprotein may be detected as isolated form by arranging amounts of added CDs.
キーワード	血清apoB含有リポタンパク質 (serum apoB lipoprotein) シクロデキストリン (cyclodextrin) 等電点電気泳動 (isoelectric focusing (IEF)) agarose gel
出版物タイトル	岡山大学医療技術短期大学部紀要
発行日	1997-01-31
巻	7巻
号	2号
開始ページ	93
終了ページ	97
ISSN	0917-4494
言語	英語
論文のバージョン	publisher
NAID	120002307426

The Influence of Film Processing Temperature and Time on Mammographic film Characteristics

JaLCDOI	10.18926/15261
タイトル（別表記）	現像温度および時間のマンモフイルム特性に与える影響
フルテキストURL	008_2_121_129.pdf
著者	丸山敏則\| 後藤佐知子\| 東義晴\| 中桐義忠\| 渋谷光一\| 杉田勝彦\| 竹内知行\| 本田貢\| 吉田彰\|
抄録	The influence for developing temperature and processing time within film processing conditions was investigated using four mammographic films, Konica New CM, Fuji UM-MA HC, Kodak Min-R M and Kodak EB/RA (for rapid system). And Fuji UR-2, a double-emulsion film, was used as a control. Those sensitometric strips exposed by a sensitometer were processed in the different combinations of developing temperatures ranging from 28 to 36℃, processing times from 45 to 210 sec. Average gradient, relative speed and base plus fog obtained from the measured film characteristic curves were evaluated for the different developing temperatures and times. Fuji UR-2 was scarcely affected and mammographic films were greatly affected in the different combinations without an increase in base plus fog except EB/RA. In New CM, UM-MA HC and Min-R M, the average gradients and the relative speeds increased as the developing temperature was higher and the developing time was longer, but the increases were limit on the combination of 36℃ and 210 sec in New CM and UM-MA HC. In EB/RA, the average gradients were almost constant and the relative speeds increased slightly like the double-emulsion film. These results suggested that it would be possible to contribute to dose reduction and advancement of contrast in New CM, UM-MA HC and Min-R M by changing these processing parameters.
キーワード	マンモグラフィ (Mammography) 現像処理パラメータ (Processing Parameter) 特性曲線 (Characteristic Curve) 平均階調度 (Average Gradient) 相対感度 (Relative Speed)
出版物タイトル	岡山大学医療技術短期大学部紀要
発行日	1998-01-31
巻	8巻
号	2号
開始ページ	121
終了ページ	129
ISSN	0917-4494
言語	英語
論文のバージョン	publisher
NAID	120002307943

Molecular typing of enterohemorrhagic Escherichia coli O157 : H7 isolates derived from an outbreak in Okayama, Japan in 1997 by pulsed-field gel electrophoresis

JaLCDOI	10.18926/15257
タイトル（別表記）	1997年岡山県下に発生した集団食中毒患者から分離された腸管出血性大腸菌EHEC O157 : H7のパルスフィールドゲル電気泳動法による遺伝子解析
フルテキストURL	008_2_091_095.pdf
著者	宮本寛治\| 坂本一成\| 新谷勝美\| 陳静\| 阿部絵理子\| 岡崎愉加\| 白井喜代子\| 合田典子\|
抄録	Thirteen enterohemorrhagic Escherichia coli O157 : H7 (EHEC) isolates derived from the patients of an outbreak in the R-hospital in Okayama Japan and one isolated from the ingredients of Japanese noodles in June 1997 were analyzed by molecular typing using pulsed-field gel electrophoresis (PFGE). The PFGE patterns of the patients were almost the same as the patterns of the Japanese noodle ingredients. Therefore, the EHEC O157 : H7 derived from the food was considered to have caused the outbreak in the R-hospital. The molecular typing of isolates from the patients and the Japanese noodle ingredients was almost the same as that of isolates from outbreaks in Hiroshima and Fukuoka prefectures classified as type Ia in 1996 by PFGE analysis. These results indicate that EHEC O157 : H7 strains with a similar PFGE type Ia pattern have already spread throughout western Japan since last year.
キーワード	EHEC O157: H7 (腸管出血性大腸菌EHEC O157 : H7) PFGE (パルスフィールドゲル電気泳動法) outbreak (集団感染) molecular typing (遺伝子解析)
出版物タイトル	岡山大学医療技術短期大学部紀要
発行日	1998-01-31
巻	8巻
号	2号
開始ページ	91
終了ページ	95
ISSN	0917-4494
言語	英語
論文のバージョン	publisher
NAID	120002307383

Affinity purification of phosphacan core protein expressed in Escherichia coli as histidine-tagged fusion protein

JaLCDOI	10.18926/15254
タイトル（別表記）	ヒスチジンタグを持つホスファカンコア蛋白の大腸菌での発現と精製
フルテキストURL	009_2_105_111.pdf
著者	伊藤昔子\| 岡本基\| 森秀治\|
抄録	Specific regions of core protein of phosphacan, one of the chondroitin sulfate proteoglycans, were expressed as fusion proteins with histidine-tag (His-tag) in Escherichia coli (E.coli) and were affinity purified using nickel-nitrilotriacetic acid (Ni-NTA) matrix. cDNA fragments encoding amino acid residues 343-446 (P3) and 1-340 (P4) of phosphacan core protein were amplified by polymerase chain reaction from E18 rat brain mRNA as template. The amplified products were subcloned into pQE30 vector and were introduced into E.coli strain M15 [pREP4] for the expression. The His-tagged fusion proteins were expressed by cultivating the transformants at 37℃ for 5h in the presence of 1mM IPTG. His-tagged P3 fusion protein (His-P3) was expressed as soluble form, and was purified using Ni-NTA matrix. His-tagged P4 fusion protein (His-P4) which was sequestered into insoluble inclusion bodies was treated with 8.0M urea to solubilize, and then was purified under denaturing conditions.
キーワード	phosphacan (ホスファカン) core protein (コア蛋白) His-tagged proteins recombinant protein (融合蛋白)
出版物タイトル	岡山大学医療技術短期大学部紀要
発行日	1999-02-26
巻	9巻
号	2号
開始ページ	105
終了ページ	111
ISSN	0917-4494
言語	英語
論文のバージョン	publisher
NAID	120002307302

衛生技術学科入学者の高校評点,入学試験成績と入学後の学業成績の関係 ―入学者選抜,教育方法の改善に向けた自己点検･評価(1)―

JaLCDOI	10.18926/15253
タイトル（別表記）	A study on the correlation between the results of entrance examination and the academic record of the students in the department of laboratory technology
フルテキストURL	009_2_091_104.pdf
著者	岡本基\| 崎山順子\| 赤塚和也\|
抄録	1987年4月から1995年4月の9年間に衛生技術学科へ入学した361名を対象に,高校評点,入学試験(学力試験)成績と,入学後の学業成績,退学,留年,臨床検査技師国家試験との関係を調べた｡ 1)入学者総数は361名で,このうち留年者が39名(10,8%),退学者が18名(5%)であった｡退学者の中には,実質入学辞退者が6名,4年制大学へ進路を変更した者が4名いたが,こうした退学者は1992年度までの入学者に多かった｡ 2)入学者全体では,予定卒業者,留年者,退学者の間で高校評点,入学試験成績には差がなかったが,入学年度ごとにみると,1987,1988年度は留年者が予定卒業者に比べて入学試験の総得点が高い傾向があり,逆に1991年,1993年度は予定卒業者に比べて有意に低かった｡ 3)高校評点は,データが入手できた1991年度以降一貫して留年者の評点が予定卒業者より低く, とくに1991年,1993年度は留年者の評点が有意に低かった｡ 4)留年者も含めて,一般教育科目の成績と専門科目の成績との間に有意を正の相関がみられた｡ 5)高校評点と入学試験成績との間には軽度の相関しかみられなかったが,高校評点および入学試験総合点は入学後の一般教育科目,専門科目の成績と高い正の相関を示した｡ 6)しかし,個々の入学試験科目の得点は,入学後の成績と相関しないか,軽度の相関しかみられなかった｡ 7)国家試験不合格者は,高校評点,入学試験総合点,一般科目平均点,専門科目平均点のいずれも合格者に比べて得点が低かったが,有意差はなかった｡以上の結果から,短期大学部開設当初は留年者,退学者の中に予定卒業者より学力のある学生がいたが,年を追うごとに入学者の学力が均質化し,学力が不十分なために留年する学生が多くなってきていると言える。一般教育科目の成績と専門科目の成績が強い正の相関を示すことは,1年次の成績がそのまま2,3年次の成績に反映されることを示しており,入学当初の動機付けと勉学意欲の喚起が重要なことを示している｡高校評点や学力試験の成績は入学後の成績とよく相関しており,学生選抜の有効な指標であると考えられたが,各入試科目との相関は乏しかったことから,個々の試験科目の問題内容については改善すべき課題があると思われた｡
キーワード	高校評点 (school record in high school) 入学試験成績 (result of entrance examination) 入学後の学業成績 (academic record) 留年 (failure in promotion) 退学 (withdrawal from school)
出版物タイトル	岡山大学医療技術短期大学部紀要
発行日	1999-02-26
巻	9巻
号	2号
開始ページ	91
終了ページ	104
ISSN	0917-4494
言語	日本語
論文のバージョン	publisher
NAID	120002307344