検索結果 13397 件
| JaLCDOI | 10.18926/15352 |
|---|---|
| フルテキストURL | Mem_Fac_Eng_OU_35_35.pdf |
| 著者 | 島村 薫| 内田 哲也| 井上 智博| |
| 抄録 | Rigid polymer, poly(p-phenylene benzobisthiazole), formed lamellar crystals where the molecular chains were oriented perpendicular to the lamellae. It was supposed that, because of wide distribution in the chain length, the lamellar surface bristled with the chain cilia among which many voids were included. Crystallographically, this region afforded us a transitional structure from full to deficient packings of chains. The structure was analyzed using the scanning probe microscope. In the course the method for imaging one molecular chain end was developed. From the images it was concluded that an isolated long cilius did not move so violently at room temperature. |
| 出版物タイトル | Memoirs of the Faculty of Engineering, Okayama University |
| 発行日 | 2001-03-27 |
| 巻 | 35巻 |
| 号 | 1-2号 |
| 開始ページ | 35 |
| 終了ページ | 40 |
| ISSN | 0475-0071 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307784 |
| JaLCDOI | 10.18926/15350 |
|---|---|
| フルテキストURL | Mem_Fac_Eng_OU_35_29.pdf |
| 著者 | 島村 薫| Munesawa Yuhji| 内田 哲也| |
| 抄録 | Poly (ethylene-block-vinyl alcohol), which consisted of both hydrophobic and hydrophilic blocks, was prepared by using polyethylene single crystals as starting material. Polyethylene single crystals reacted with fuming nitric acid resulting in long methylene chains with functional groups such as COOH and NO(2) at the ends (the chain length were almost same as the lamellar thickness of polyethylene single crystal). The functionalized methylene chains were allowed to react with 4-aminostyrene to give corresponding amides, i.e., methylene chains with vinyl groups at the ends (macromer). The macromers were extended by block-copolymerization with vinyl acetate, then saponified resulting in PE/PVA block co-polymer. The block copolymer was molded into sheets which were subsequently heat-treated in contact with hydrophilic or hydrophobic media. Depending on the media, the sheet surface changed at high temperature reversibly from hydrophilic to hydrophobic and vice versa. The surface property was fixed by quenching because both blocks were able to crystallize. Thus the surface of this material can be tailored for various purposes at high temperature, and then used in stable at room temperature. |
| 出版物タイトル | Memoirs of the Faculty of Engineering, Okayama University |
| 発行日 | 2001-03-27 |
| 巻 | 35巻 |
| 号 | 1-2号 |
| 開始ページ | 29 |
| 終了ページ | 34 |
| ISSN | 0475-0071 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307155 |
| JaLCDOI | 10.18926/15348 |
|---|---|
| フルテキストURL | Mem_Fac_Eng_OU_35_21.pdf |
| 著者 | S.kovalenko, Volodymyr| Uno, Yoshiyuki| Okamoto, Yasuhiro| Anyakin, M.| Lutay, A.| Shubul, Khaled Al.| |
| 抄録 | In electric power industry, there is a problem of achieving stable joint in different components using high productive and efficient technologies. One type of these components is packages of slices for magnetic circuit of electric motors, transformers etc., which need reliable means for their fixing. Laser welding is proposed to solve this problem as an alternative for existing technologies. The development of the laser welding process is presented based on process simulation, study of heat history and comparison with experimental results. Laser beam additional scanning technique is proposed to improve the quality and efficiency of the joining operation. |
| 出版物タイトル | Memoirs of the Faculty of Engineering, Okayama University |
| 発行日 | 2001-03-27 |
| 巻 | 35巻 |
| 号 | 1-2号 |
| 開始ページ | 21 |
| 終了ページ | 28 |
| ISSN | 0475-0071 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307424 |
| JaLCDOI | 10.18926/15346 |
|---|---|
| フルテキストURL | Mem_Fac_Eng_OU_35_9.pdf |
| 著者 | 阿部 武治| 坪井 智昭| |
| 抄録 | The evaluation of microscopic inhomogeneity of polycrystalline aluminum is performed by measuring the hardness in respective grains. The recently developed ultra-micro hardness tester is used and the effects of the test pattern, the indentation load and the indenting velocity are examined. Then, the relationship between the increase in the hardness caused by the work hardening and the deformation of respective grains are statistically investigated. The hardness testing mode in which the initial load is applied before the onset of measurement gives more stable results than the testing mode without the initial load. The test condition with the indentation load of 9.8mN and the indentation velocity of 0.2 μm/sec seems to be optimum and gives the least dispersion of the measured values in grains. It is shown that the hardness values of respective grains in polycrystalline aluminum as well as their dispersion increase with the applied plastic strain. Discussion is made on the microscopic deformation behavior of polycrystalline aluminum. |
| 出版物タイトル | Memoirs of the Faculty of Engineering, Okayama University |
| 発行日 | 2001-03-27 |
| 巻 | 35巻 |
| 号 | 1-2号 |
| 開始ページ | 9 |
| 終了ページ | 19 |
| ISSN | 0475-0071 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307825 |
| JaLCDOI | 10.18926/15345 |
|---|---|
| タイトル（別表記） | 気管支喘息の発症における加齢の影響について |
| フルテキストURL | 063_142_147.pdf |
| 著者 | 光延 文裕| 貴谷 光| 岡崎 守宏| 御舩 尚志| 谷崎 勝朗| |
| 抄録 | Skin tests, serum total IgE levels, specific IgE antibodies against each allergen, bronchial reactions provoked by allergens and histamine release from basophils are well known as prameters of immediate allergic reactions. The incidence of positive immediate skin reaction to allergens such as house dust, ragweed, Aspergillus Alternaria, Cladosporium and Broncasma decreased with aging. On the other hand, the incidence of positive skin reaction to Candida albicans was higher in cases between the age of 41 and 50 and cases over the age of 61 compared to that in the other groups classified by age. Serum IgE levels was highest in cases aged between 0 and 30. The levels of serum IgE decreased with aging. The incidence of positive RAST scores (more than 2+) and positive bronchial reaction to house dust were highest in cases between 0 and 30, and decreased with aging. However, the positive ratio of these tests against C. albicans were highest in cases between 41 and 50. The degree of histamine release from basophils of asthmatics induced by anti-IgE was consistently high without any correlation to aging when their serum IgE levels were more than 501 IU/ml. In the cases with serum IgE levels of less than 300 IU/ml, basophil reactivity to anti-IgE decreasd with aging. Basophil reactivity to house dust was generally dependent on the levels of specific IgE antibodies against the allergen. Although basophil reactivity to C. albicans was also high in cases with positive RAST scores, some cases with a RAST score of 0+ or 1+ showed high or moderate basophil reactivity. Moderate or high reactivity of basophils was frequently observed in cases between 41 and 50 and cases over age 61. |
| キーワード | Skin test (皮内反応) IgE Provocation test (吸入誘発試験) Basophil reactivity (好塩基球の反応性) Aging (加齢) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 142 |
| 終了ページ | 147 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307130 |
| JaLCDOI | 10.18926/15344 |
|---|---|
| フルテキストURL | Mem_Fac_Eng_OU_35_1.pdf |
| 著者 | 阿部 武治| Hualin Song| Akagi Yasuo| 清水 一郎| |
| 抄録 | Free surface of polycrystalline metal becomes roughened after plastic deformation. The surface roughening is closely related to the inhomogeneity of polycrystalline metals, that is, to the inhomogeneous plastic deformation of respective grains. In the present study, inhomogeneous deformation on the free surface of polycrystalline aluminum specimen during uniaxial tension is studied. The inhomogeneous deformation of grains in the central area of the free surface of specimen is observed by the laser scanning microscope, while the inhomogeneous deformation perpendicular to the surface is studied by the laser scanning microscope as well as the stylus measuring instrument. It is shown that the surface roughness and the strain of respective grains increase with the applied strain. Discussions are made on the change in the surface roughness, the strain in each grain and the slip-line angles with the applied strain. |
| 出版物タイトル | Memoirs of the Faculty of Engineering, Okayama University |
| 発行日 | 2001-03-27 |
| 巻 | 35巻 |
| 号 | 1-2号 |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 0475-0071 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307340 |
| JaLCDOI | 10.18926/15343 |
|---|---|
| タイトル（別表記） | 抗原および抗ヒトIgEに対する抗塩基球の反応性. 3.Ca2(+)の細胞内流入およびヒスタミン遊離 |
| フルテキストURL | 063_134_141.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 岡崎 守宏| 御舩 尚志| 光延 文裕| 木村 郁郎| |
| 抄録 | The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE. |
| キーワード | Ca(2+) influx (Ca2+流入) histamine release (ヒスタミン遊離) house dust (ハウスダスト) Candida albicans (カンジダ) anti-lgE (抗ヒトIgE) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 134 |
| 終了ページ | 141 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307872 |
| JaLCDOI | 10.18926/15341 |
|---|---|
| タイトル（別表記） | 抗原および抗ヒトIgEに対する好塩基球の反応性. 2.分泌機序における形態的変化 |
| フルテキストURL | 063_128_133.pdf |
| 著者 | 谷崎 勝朗| 高橋 清| 木村 郁郎| |
| 抄録 | Morphological changes of blood basophils activated by antigen and anti-IgE were discussed in relation to release mechanisms of the cells. 1. Basophils activated by antigen and anti-IgE show two different types : A form (pear-shaped) and B from (swollen type), on smear preparartions. 2. Pear-shaped basophils(reactive basophils), which appear after stimulation by antigen and anti-IgE, can be observed by the staining solution for the direct count of basophils and eosinophils. 3. The incidence of reactive basophils increases after addition of antigen. Thus, observation of reactive basophils can be clinically applied for detecting allergen (DCRB ; direct connt of reactive basophils). 4. Observation of morphological basophil response by phase- contrast microscopic motion pictures demonstrates that basophils activated by antigen show two different reponses, increase in motility (oriented movement) and degranulation. |
| キーワード | morphological changes of basophils (好塩基球の形態的変化) reactive basophils (反応好塩基球) degranulation (脱顆粒) histamine release (ヒスタミン遊離) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 128 |
| 終了ページ | 133 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/15339 |
|---|---|
| タイトル（別表記） | 抗原および抗ヒトIgEに対する好塩基球の反応性. 1.好塩基球数の変化 |
| フルテキストURL | 063_123_127.pdf |
| 著者 | 谷崎 勝朗| 木村 郁郎| |
| 抄録 | Blood basophils in subjects with bronchial asthma migrate from blood stream into local allergic reaction sites after inhalation of antigen into airways. The phenomena can be observed by changes in number of basophils in the peripheral blood. The peripheral basophil count is at a normal level in non-attack stage of asthmatics as in healthy subjects. The basophil count increases in pre-attack stages, and decreases during attack stages. These findings suggest that number of basophils changes in close relation to asthma cycle, and that by observing number of basophils in the peripheral blood, it is possible to detect near future attacks. The decrease in number of basophils and histamine release by stimulation with antigen and anti-IgE can be observed in vitro in whole blood and basophils separated by density gradient centrifugation and by counterflow centrifugation elutriation. The decreased number of basophils in the peripheral blood represents migration of the cells into local allergic reaction sites. |
| キーワード | basophils (好塩基球) bronchial asthma (気管支喘息) asthma cycle (喘息発作) histamine release (ヒスタミン遊離) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 123 |
| 終了ページ | 127 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307920 |
| JaLCDOI | 10.18926/15331 |
|---|---|
| タイトル（別表記） | ラット腹腔肥満細胞のCa(2+) influxおよびヒスタミン遊離に対する抗アレルギー薬アゼラスチンの抑制効果について |
| フルテキストURL | 063_089_094.pdf |
| 著者 | 谷崎 勝朗| 大谷 純| 木村 郁郎| |
| 抄録 | The effect of antiallergic agent, azelastine, was examined in immunogical secretory process of mast cells. 1. Azelastine significantly inhibited (45)Ca uptake by mast cells stimulated by antigen, and the maximum inhibition was attained at a concentration of 50 μg/ml showing approximately 30.5 % inhibition. 2. Azelastine also inhibite the release of histamine from mast cells by antigen. The maximal inhibitory rate was 38.1%. The effect of azelastine on (45)Ca uptake and histamine release was dose-dependent, and compatible at employed cocentration of the agent. 3. Tachpylaxis to azelastine was not found in this experimental system. |
| キーワード | Azelastine (アゼラスチン) Rat mast cells (ラット肥満細胞) (45)Ca uptake (Ca(2+)uptake) Histamine release (ヒスタミン遊離) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 89 |
| 終了ページ | 94 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307786 |
| JaLCDOI | 10.18926/15325 |
|---|---|
| タイトル（別表記） | 気管支喘息患者における細胞性免疫,ガンジダ抗原に対する遅延型反応の抑制 |
| フルテキストURL | 063_069_073.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 岡崎 守宏| 御舩 尚志| 光延 文裕| 原田 英雄| 越智 浩二| 木村 郁郎| |
| 抄録 | Delayed cutaneous hypersensitivity towards Candida albicans was examined in 200 patients with bronchial asthma in relation to patient age and the level of total IgE. 1. Delayed skin reactivity towards C.albicans was depressed in the patients between the ages of 10 and 20 and in those over the age of 61. A significant difference was present in delayed skin reactivity between the groups of 10-20 and 41-50 years old. 2. The frequency of the patients with positive delayed skin reactivity towards C.albicans was the highest in those with low levels of total IgE (0 -100 IU/ml) and the low est in those with high levels of total IgE (over than 1001 IU/ml). The results suggest that cell-mediated immunity towards C.albicans is depressed re lating to atopics in the patients between 10 and 20 and to aging in the patients over 61. |
| キーワード | cell-mediated immunity (細胞性免疫) bronchial asthma (気管支喘息) atopics (アトピー) aging (加齢) カンジダ |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 69 |
| 終了ページ | 73 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307949 |
| JaLCDOI | 10.18926/15324 |
|---|---|
| タイトル（別表記） | 臨床所見および検査成績からのスコアーによる喘息分類の特徴 |
| フルテキストURL | 063_063_068.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 岡崎 守宏| 御舩 尚志| 光延 文裕| 谷水 将邦| 本家 尚子| 草浦 康浩| 高取 明正| 奥田 博之| 木村 郁郎| |
| 抄録 | Twenty six patients with bronchial asthma was classified by clinical symptoms and singns (clinical diagnosis), and the classification by clinical diagnosis was compared with the classification by a score calculated from clinical findings and examinations (score diagnosis). 1. Of 12 subjects with type Ia classified by clinical diagnosis, 8 cases with 0 to 49 ml/day of expectoration were evaluated as type Ia by score diagnosis. While four type Ia cases with 50 to 99ml/day of expectoration were calssified as type Ib by score diagnosis. The increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF) of these four cases was similar to the incidence in type Ib cases with hypersecretion. 2. All of 6 subjects with type Ib by clinical diagnosis were estimated as type Ib by score diagnosis. 3. Of 8 cases with type II by clinical diagnosis, 7 cases were assessed as type II by score diagnosis. One case with type II by clinical diagnosis and with the score of 10 points was evaluated as questionable type II by score diagnosis. |
| キーワード | asthma classification (喘息分類) bronchoconstriction (気管支攣縮) hypersecretion (過分泌) bronchiolar obstruction (細気管支閉塞) score diagnosis (スコアー診断) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 63 |
| 終了ページ | 68 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307348 |
| JaLCDOI | 10.18926/15322 |
|---|---|
| タイトル（別表記） | 高齢者健常人および気管支喘息患者におけるカンジダ特異的IgGおよびIgG(4)抗体について |
| フルテキストURL | 063_058_062.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 岡崎 守宏| 御舩 尚志| 光延 文裕| 古藤 直樹| 多田 慎也| 木村 郁郎| |
| 抄録 | Specific IgG and IgG(4) antibodies against Canadida albicans were exmined in 48 healthy and 69 asthmatic subjects to analyze the mechanism causing an increased production of these immunoglobulins. 1. The level of C.albicans-specific IgG and IgG(4) antibodies was higher, not significantly in IgG(4), in asthmatics under 30 years of age, compared with healthy subjects of the same age group. 2. Specific IgG and IgG(4) antibody levels in both healthy and asthmatic subjects showed a tendency to increase with aging, and significant difference was present between cases under 30 years and cases over 70 years of age. 3. Any difference in the production of specific IgG and IgG(4) was not observed in elderly cases older than 60 years between healthy and asthmatic subjects. |
| キーワード | Candida albicans (カンジダ特異的IgG) Specific IgG IgG(4) Bronchial asthma (気管支喘息) Aging (加齢) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 58 |
| 終了ページ | 62 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307284 |
| JaLCDOI | 10.18926/15321 |
|---|---|
| タイトル（別表記） | IgE受容体を介する刺激に対する好塩基球の形態的変化の顕微鏡的観察. 抗原と抗IgE刺激の特徴とその相違点 |
| フルテキストURL | 063_050_057.pdf |
| 著者 | 谷崎 勝朗| 中川 三郎| 木村 郁郎| |
| 抄録 | Differences in morphological changes of basophils between antigen and anti-IgE stimulation were examined in atopic subjects in relation to histamine release. 1. Antigen- induced release of histamine was remarkably more rapid and larger at any incubation time than the release by anit-IgE, and a significant difference was found at 3 to 9 min. 2. Decrease in number of basophils induced by antigen was significantly higher for 12 to 15 min incubation time than that by anti-IgE. 3. Morphological changes of basophils representing increased motility such as an increased ratio of short to long axis diameter (L/S ratio) and an increased incidence of basophils with localized granules (LG) were more often observed in antigen stimulation compared with anti-IgE, and the L/S ratio of the cells was significantly more increased in antigen stimulation at 6 and 15 min. 4. There was no difference in morphological changes of basophils showimg swollen type (degranulation) such as an increased mean diameter (MD) of the cells between antigen and anti-IgE. These results suggest that antigen activates basophils and induces increased motility more strongly than anti-IgE, but the action on degranulation was not different between the two agents. |
| キーワード | Histamine release (ヒスタミン遊離) Morphological changes of basophils (好塩基球の形態的変化) Antigen (抗原) Anti-IgE (抗IgE) IgE receptors (IgE受容体) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 50 |
| 終了ページ | 57 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307320 |
| JaLCDOI | 10.18926/15320 |
|---|---|
| タイトル（別表記） | 気管支喘息における気道の反応性および炎症反応におよぼす加齢の影響について |
| フルテキストURL | 064_089_096.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 原田 英雄| 木村 郁郎| |
| 抄録 | Ventilatory function, cellular composition in bronchoalveolar lavage (BAL) fluid and release of chemical mediators from leucocytes were examined in 25 older asthmatics (mean age 66.7 years) and 25 younger asthmatics (mean age 45.1 years) in relation to clinical asthma types. 1. Ventilatory function tests showed that the values of ventilatory parameters such as % MMF, % V(50) and % V(25) were lower in older subjects than in younger subjects, and a significant difference was found in the % V(50) value between the two age groups. Regarding clinical asthma types, the values of % MMF, % V(50), and V(25) were significantly lower in both younger and older subjects with type II. 2. In analysis of cellular composition in BAL fluid, the proportion of BAL lymphocytes was significantly lower in type II older subjects than in younger subjects with the same type. A significantly increased proportion of BAL neutrophils was observed in both younger and older subjects with type II. 3. The release of leukotriene C(4) (LTC(4)) from leucocytes was significantly lower in type II older subjects than in younger subjects with the same type, and LTC(4) release in patients with type II was also significantly lower than that in those with other asthma types in both younger and older subjects. The release of histamine and leukotriene B(4) (LTB(4)) from leucocytes was not significantly different between the two age groups. These results demonstrate that ventilatory function, cellular composition in BAL fluid, and the release of chemical mediators from leucocytes are affected by aging and clinical asthma types. |
| キーワード | Ventilatory function (換気機能) Cellular composition in BAL fluid (気道内細胞成分) chemical mediators (化学伝達物質) aging (加齢) clinical asthma type (臨床病型) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 89 |
| 終了ページ | 96 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307744 |
| JaLCDOI | 10.18926/15318 |
|---|---|
| タイトル（別表記） | 老令者の気管支喘息,各臨床病型における換気機能の特徴 |
| フルテキストURL | 063_044_049.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 岡崎 守宏| 御舩 尚志| 光延 文裕| 谷水 将邦| 本家 尚子| 草浦 康浩| 高取 明正| 奥田 博之| 木村 郁郎| |
| 抄録 | Ventilatory function was examined in 20 elderly patients with bronchial asthma in relation to clinical asthma types, and the results were compared with those of younger asthmatics. 1. Ventilatory parameters such as FEV(1.0%), % PEFR, % MMF, % V(50) and % V(25), which repressent obstructive ventilatory dysfunction, were in general lower in older asthmatics than in the youger cases. 2. The values of % V(50) and % V(25), representing ventilatory dysfunction in small airways, were significantly lower in the older subjects with type Ib and II compared to the younger cases with same types. 3. Markedly decreased values in ventilatory parameters, particularly in % MMF, % V(50) and % V(25) were observed in both older and younger subjects with type II. The results suggest that ventilatory function decreases with aging and the decrease is related to the pathophysiological changes in the airways. |
| キーワード | Ventilatory function (換気機能) small airways (細気管支) clinical asthma types (臨床病型) elderly asthmatics (老年者気管支喘息) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 44 |
| 終了ページ | 49 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307531 |
| JaLCDOI | 10.18926/15316 |
|---|---|
| タイトル（別表記） | 老年者の気管支喘息. アレルギー反応と気道細胞反応 |
| フルテキストURL | 063_039_043.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 岡崎 守宏| 御舩 尚志| 光延 文裕| 谷水 将邦| 本家 尚子| 草浦 康浩| 越智 浩二| 原田 英雄| 木村 郁郎| |
| 抄録 | Clinical features of bronchial asthma in the elderly were analyzed by observlng IgE-mediated allerglc reactions evaluated by immediate skin reaction and specific IgE antibodies to allergens, ventilatory function and cellular composition in bronchoalveolar lavage (BAL) fluid. 1. The frequency of positive immediate skin reaction and positive RAST score to allergens was in general low in the elderly patients over age 70. 2. Ventilatory function was widely variegated, and fifteen cases (60%) of the 25 Subjects showed considerably high values of FEV(l.0%), % PEFR, % MMF, % V(50) and % V(25), and the mean value of FEV(1.0%) in these cases was 71.3%. 3. The decreased value of % V(25) was related to BAL neutrophilia in 2 cases, but any correlation was not found between BAL neutrophilia and decreased value of % V(25) in 9 csese of the eleven subjects who had the BAL examination. The results show that in asthma of elderly patients, IgE-mediated allergic reactions are weak, and that a decreased value of % V(25) can be observed without BAL neutrophilia. |
| キーワード | elderly subjects (老年者) lgE-mediated allergic reaction (IgE系反応) ventilatory function (換気機能) BAL neutrophilia (BAL好中球) bronchial asthma (気管支喘息) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 39 |
| 終了ページ | 43 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307727 |
| JaLCDOI | 10.18926/15314 |
|---|---|
| タイトル（別表記） | 気管支肺胞洗浄液中に一過性の好中球増多をきたしたアトピー型喘息 |
| フルテキストURL | 064_052_059.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 瓦屋 正志| 中桐 善康| 多田 慎也| 木村 郁郎| |
| 抄録 | Clinical course of one asthma patient (64 years old, female), who had an increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid, was observed in relation to the proportion of BAL cells and ventilatory function. The patient had large asthma attacks two times during her clinical course for 15 months observed. 1. An increased proportion of BAL neutrophils and suppression of ventilatory function were found after her first large asthma attacks. The increased proportion of BAL neutrophils continued for more than 5 months. A reduction in the proportion of BAL neutrophils was found 3 months after her second large asthma attack, accompanied by improvement of clinical symptoms and ventilatory function. The numbers of total cells and neutrophils in BAL fluid were also reduced. Transient increase in number of BAL lymphocytes was found 13 months after the first large attack when the number of BAL neutrophils was markedly decreased. The number of BAL eosinophils did not change during her clinical course. |
| キーワード | Bronchial asthma (気管支喘息) transient BAL neutrophilia(一過性BAL液中好中球増多) ventilatory function (換気機能) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 52 |
| 終了ページ | 59 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307805 |
| JaLCDOI | 10.18926/15313 |
|---|---|
| フルテキストURL | 063_034_038.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 岡崎 守宏| 御舩 尚志| 光延 文裕| 谷水 将邦| 本家 尚子| 草浦 康浩| 木村 郁郎| |
| 抄録 | The serum levels of total IgE, IgG and IgG(4) were compared among five age groups of patients with bronchial asthma. 1. The level of serum IgE was significantly higher in the patients before the age of 29 than in those between the ages of 30 and 49 (p < 0.02), between 50 and 59 (p < 0.01) and between 60 and 69 (p < 0.01). The serum IgE level tended to increase in the patients over age 70. 2. The serum level of total IgG was significantly higher in the patients over age 70 compared with the level in the 30-49 (p < 0.05) and the 60-69 year old groups (p < 0.05). 3. The serum IgG(4) level was increased with aging, although no significant difference was found among the five age groups. 4. The IgG(4) level correlated to a certain extent with the level of serum IgE. The results reveal that the levels of total IgE, IgG and IgG(4) are increased in the elderly patients over age 70, and that there is a relationship between serum levels of total IgE and IgG(4). |
| キーワード | Total IgE IgG IgG(4) aging bronchial asthma |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1992-06 |
| 巻 | 63巻 |
| 開始ページ | 34 |
| 終了ページ | 38 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307767 |
| JaLCDOI | 10.18926/15312 |
|---|---|
| タイトル（別表記） | 老年者気管支喘息における気道炎症細胞.喘息重症度と関連した気道細胞反応の特徴 |
| フルテキストURL | 064_083_088.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 中桐 善康| 原田 英雄| 木村 郁郎| |
| 抄録 | Cellular composition of bronchoalveolar lavage (BAL) fluid was examined in 11 elderly asthmatics over the age of 70, and the results were compared with those of 11 younger asthmatics under the age of 50. In the subjects with mild asthma, the proportion of BAL cells in the elderly subjects was 86.2% macrophages, 11.0% lymphocytes, 1.9% neutrophils, 0.9% eosinophils and 0.08% basophilic cells. The proportion of neutrophils and eosinophils in the BAL fluid was slightly higher in younger subjects with mild asthma compared with that in elderly subjects, although no significant difference was found between the two groups. In subjects with severe asthma, the proportions of lymphocytes, neutrophils, eosinophils and basophilic cells were more increased in both younger and older patients compared to those with mild asthma, and a significant increase in the number of BAL eosinophils was found in younger subjects with severe asthma compared to those with mild asthma (p < 0.05). However, no significant difference was present in the proportion of BAL cells between younger and older patients with severe asthma. The results reveal that BAL cells are more increased in subjects with suvere asthma than in those with mild asthma in both younger and older subjects, and show the possibility that this increase is more predominant in neutrophils in older subjects and in eosinophils in younger subjects. |
| キーワード | Neutrophils (好中球) Eosinophils (好酸球) Bronchoalveolar lavage (気管支肺胞洗浄) asthma severity (喘息重症度) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 83 |
| 終了ページ | 88 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307736 |