検索結果 - 岡山大学学術成果リポジトリ

Association of the mean CT number by high resolution computed tomography (HRCT) with generation of leukotrienes B4 (LTB4) and C4 (LTC4) in patients with pulmonary emphysema

JaLCDOI	10.18926/14953
タイトル（別表記）	肺気腫患者におけるロイコトリエンB4,C4産生能と高分解能CTによる平均CT値との関連
フルテキストURL	069_015_020.pdf
著者	光延文裕\| 御舩尚志\| 保崎泰弘\| 芦田耕三\| 柘野浩史\| 岡本誠\| 原田誠之\| 湯本英一郎\| 高田真吾\| 越智浩二\| 原田英雄\| 長谷川晴巳\|
抄録	The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leukocytes stimulated with Ca ionophore A23187 was examined in 17 patients with pulmonary emphysema. They were divided into three groups according to the mean CT number; A (<-940 HU), B (-940 ≦, <-930 HU), and C (-930 HU ≦ ).1. The values of FVC (% predicted), FEV1.0% and DLco (% predicted) showed a tendency to decrease as the mean CT number was smaller. The value of % FVC was significantly lower in patients with group A than in those with group C (p<0.05). 2. The generation of both LTB4 and LTC4 was significantly higher in patients with emphysema compared to the generation in healthy subjects (LTB4;p<0.05, LTC4;P<0.05). 3. The generation of LTB4 and LTC4 in patients with emphysema was higher as the mean CT number was larger (severity of the disease become less). The LTC4 production was significantly higher in patients with group C(mild or moderate type of emphysema) than in those with group A(advanced type of emphysema). These results suggest that the generation of LTB4 and LTC4 is higher in patients with mild or moderate type of emphysema than in those with advanced type of the disease.
キーワード	emphysema mean CT number LTB4 LTC4
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	15
終了ページ	20
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308094

Leukotrienes B4 and C4 generation by peripheral leucocytes in patients with asthma

JaLCDOI	10.18926/14951
タイトル（別表記）	気管支喘息における末梢血白血球のロイコトリエンB4およびC4産生能
フルテキストURL	069_009_014.pdf
著者	谷崎勝朗\| 光延文裕\| 御舩尚志\| 保崎泰弘\| 芦田耕三\| 柘野浩史\| 岡本誠\| 原田誠之\| 湯本英一郎\| 高田真吾\| 越智浩二\| 原田英雄\|
抄録	The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 16 patients with asthma (8 with atopic and 8 with nonatopic asthma) and 12 healthy controls. 1. The LT84 generation by leucocytes was not significantly different between patients with asthma and healthy controls. The generation of LTC4 was significantly larger in patients with asthma than in healthy controls. The LTC4 generation was also significantly larger in patients with attacks (58.4 ± 38.5 ng/5x10(6) cells) than in those without attacks (23.3 ± 25.9 ng/5x10(6) cells)(p<0.05). 2.ln atopic asthma, the LTC4 production was significantly larger in patients with attacks (84.7 ± 35.4 ng/5x10(6) cells) compared to the production in those without attacks (40.4 ± 27.2 ng/5x10(6) cells)(p<0.02). However, the production of LTB4 was not significantly different between attack and attack-free stages. 3. In nonatopic asthma, the LTC4 production was also significantly higher in patients with attacks (32.2 ± 26.3 ng/5x10(6) cells) than in those without attacks (12.2 ± 3.5 ng/5x10(6) cells)(p<0.05). However, the LTB4 production was not significantly different between attack and nonattack stages. 4. The LTC4 production was significantly larger in atopic asthmatics compared to the production in nonatopic subjects both in attack and nonattack stages. These results suggest that the generation of LTC4 by leucocytes of patients with asthma is closely related to IgE-mediated reaction and asthma attacks.
キーワード	bronchial asthma LTB4 LTC4 IgE-mediated reaction asthma attacks
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	9
終了ページ	14
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308181

Clinical and experimental aspects of free radicals in chronic pancreatitis

JaLCDOI	10.18926/14942
タイトル（別表記）	臨床的および実験的側面からみた慢性膵炎とフリーラジカル
フルテキストURL	070_079_083.pdf
著者	越智浩二\| 松村直樹\| 水島孝明\| 光延文裕\| 谷崎勝朗\|
抄録	Free radicals have been suspected to play an important role in the pathogenicity of chronic pancreatitis. We reviewed studies on free radicals in chronic pancreatitis in both c1inical and experimental aspects. Many clinical studies have provided circumstantial evidence for the close relation between free radicals and chronic pancreatitis. However, few experimental studies in animals on relation between free radicals and chronic pancreatitis have been reported, because adequate experimental models for elucidating a pathological role of free radicals in chronic pancreatitis have not been established. The research concerning the role of free radicals in chronic pancreatitis is expected to improve our understanding the pathological mechanisms of the disease.
キーワード	慢性膵炎 (chronic pancreatitis) フリーラジカル (free radicals)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	79
終了ページ	83
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308147

The relationship between the magnetic resonance imaging of the lumbar spine and low back pain

JaLCDOI	10.18926/14936
タイトル（別表記）	腰椎MRI画像と腰痛の関係
フルテキストURL	070_067_072.pdf
著者	高田真吾\| 湯本英一朗\| 岡本誠\| 柘野浩史\| 原田誠之\| 保崎泰弘\| 御舩尚志\| 光延文裕\| 谷崎勝朗\| 原田実根\|
抄録	The purpose of this study was to examine the potential role of magnetic resonance imaging (MRI) in the evaluation of low back pain (LBP). The study group, 19 patients with low back pain (2 subjects aged 32-39 years and 17 aged 59-78), underwent MRI of the lumbar spine. Disc degeneration at L4/5 was the most common finding (68.4%). Overall in present study, all patients with LBP had abnormalities around the lumbar spine (evidence of disc degeneration, deformity of lumbar spine, disc bulging or protrusion, facet hypertrophy, nerve root compression and so on).
キーワード	MRI (Magnetic resonance imaging) 腰椎 (Lumbar spine) 椎間板変性 (Disc disease)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	67
終了ページ	72
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308559

Cortical bone porosity in patients with asthma

JaLCDOI	10.18926/14934
タイトル（別表記）	気管支喘息症例における皮質骨海綿化
フルテキストURL	070_053_060.pdf
著者	柘野浩史\| 中井睦郎\| 岡本誠\| 原田誠之\| 高田真吾\| 御舩尚志\| 光延文裕\| 芦田耕三\| 保崎泰弘\| 穐山恒雄\| 辻孝夫\| 谷崎勝朗\|
抄録	In previous studies, we have demonstrated that chronic administration of systemic glucocorticoids decreases cortical bone mineral density (BMD), cortical bone volume, bone strength, and induces development of pathologic fractures in asthmatic patients. We have also demonstrated that glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites in postmenopausal asthmatic patients. There is a difference of gonadal hormones between male and female. To investigate the influence of hormonal difference on glucocorticoid-induced cortical bone porosity, we studied cortical bone volume and BMD in both male and female patients with asthma in this report. A total of 99 asthmatic patients (male 26 cases, female 73 cases) were enrolled in the study. Peripheral quantitative computed tomography (pQCT) was used to measure cortical BMD and relative cortical volume. The cortical volume-density relationship appeared to remain constant regardless of the level of systemic glucocorticoid administration, age or sex, suggesting cortical bone porosity causes similar and simultaneous decreases in cortical bone volume and density. In conclusion, glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites despite the gonadal hormonal differences.
キーワード	bronchial asthma systemic glucocorticoid cortical bone cortical porosity peripheral quantitative computed tomography
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	53
終了ページ	60
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308477

Factors influencing the effects of dietary supplementation　with PUFAs on leukotriene generation by leucocytes in　patients with asthma

JaLCDOI	10.18926/14933
タイトル（別表記）	気管支喘息患者における白血球ロイコトリエン産生能に対する不飽和脂肪酸食の効果に影響する因子
フルテキストURL	070_043_052.pdf
著者	岡本誠\| 光延文裕\| 芦田耕三\| 御舩尚志\| 保崎泰弘\| 柘野浩史\| 原田誠之\| 高田真吾\| 谷崎勝朗\| 片岡幹男\| 新谷憲治\| 原田実根\|
抄録	Dietary supplementation with perilla seed oil, a vegetable oil rich in α -lin- olenic acid, inhibits the generation of leukotrienes(LTs) by leucocytes in patients with bronchial asthma. We examined the factors that affect the suppression of LT generation by leucocytes with perilla seed oil-rich supplementation in patients with asthma, by comparing the clinical features of patients with asthma, whose generation of leukotriene (LT) C4 was suppressed by dietary supplementation with perilla seed oil (n-3 fatty acids) (group A), with those of patients who showed no suppression of LTC4 generation (group B). Group A showed a significant increase in the generation of LTB4 and L TC4 by leucocytes after corn oil-rich supplementation (n-6 fatty acids), and a significant decrease in the generation of LTB4 and LTC4 after perilla seed oil-rich supplementation (n-3 fatty acid). However, this was not observed in group B. The level of serum IgE and peak expiratory flow (PEF) in group A were significantly higher than in group B. Furthermore, the serum levels of LDL-cholesterol, β-lipoprotein and　phospholipid were significantly lower in group A than in group B. These results suggest that the clinical features differ between these two asthmatic populations with respect to suppression of LTB4 and LTC4 generation by n-3 fatty acids in perilla seed oil-rich supplementation.
キーワード	エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) ロイコトリエン (leukotrienes) IgE 脂質代謝 (lipometabolism)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	43
終了ページ	52
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308623

Graphs for Menshikov-Zuev's Problems on ρ-percolation Model

JaLCDOI	10.18926/OER/14929
フルテキストURL	40_4_115_125.pdf
著者	村井浄信\|
抄録	In 1993, Menshikov and Zuev introduced ρ−percolation model, in which a path of a graph is ρ−passable in a bond percolation configuration if the concentration of open bonds on it is at least ρ, and concerning this model, they gave four open problems. In this paper, we answer three problems out of them : the first one is whether the ρ−percolation critical probability is equal to the critical probability corresponding to finite/infinite expectation of the number of ρ−connectable vertices from a fixed vertex, the second is whether the 1-p ercolation critical probability is equal to the Bernoulli bond percolation critical probability, and finally the third is whether the probability of the existence of ρ−passable path of length exceeding n starting from a fixed vertex always decays exponentially in the subcritical phase.
出版物タイトル	岡山大学経済学会雑誌
発行日	2009-03-10
巻	40巻
号	4号
開始ページ	115
終了ページ	125
ISSN	0386-3069
関連URL	http://www.e.okayama-u.ac.jp/~shiryou/gakkaishi.htm
言語	英語
著作権者	岡山大学経済学会
論文のバージョン	publisher
NAID	120002308476

Evaluation of Body Surface Temperature by Thermography 3. Correlation between the peripheral circulation estimatedby Laser-Doppler blood flowmetry and thermography.

JaLCDOI	10.18926/14927
タイトル（別表記）	サーモグラフィーによる体表面温度の測定 3.体表面温度の回復率と末消血流量との相関
フルテキストURL	070_036_042.pdf
著者	保崎泰弘\| 高田真吾\| 光延文裕\| 御舩尚志\| 芦田耕三\| 柘野浩史\| 岡本誠\| 原田誠之\| 谷崎勝朗\| 越智浩二\| 辻孝夫\|
抄録	The body surface peripheral circulation in 12 cases,　including 9 patients with　diabetes mellitus who were suffering coldness, numbness or pain in their feet, and 3 healthy volunteers was examined using Laser-Doppler blood flowmetry. At the same time, the body surface temperature was estimated by thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio = [Total counts of thermography(Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). The recovery ratio and the blood flow were correlated, r=0.68, p
キーワード	サーモグラフィー (thermography) レーザードプラー血流計 (Laser-Doppler blood flowmetry) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	36
終了ページ	42
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308240

Relationship between bronchial hyperresponsivenessand nasosinus lesions in patients with bronchial asthma

JaLCDOI	10.18926/14926
タイトル（別表記）	気管支喘息症例における気道過敏性と鼻腔･副鼻腔疾患の関係に関する検討
フルテキストURL	070_028_035.pdf
著者	御舩尚志\| 高田真吾\| 岡本誠\| 柘野浩史\| 芦田耕三\| 原田誠之\| 光延文裕\| 保崎泰弘\| 谷崎勝朗\| 原田実根\|
抄録	Pathological changes of nasosinus occur often in subjects with bronchial asthma. Coexisting nasosinus lesion may affect pathophysiology of lower respiratory tract in asthmatics. The extent of nasal and sinus lesion was quantified in 17 patients with bronchial asthma, and their relationships to atopic status, asthma severity and bronchial hyperresponsiveness were evaluated in this study. Opacification degree of maxillary sinuses and nasal mucosa thickening were quantified using CT scans. The opacification degree was evaluated as (total opacification area)/(total maxillary sinus area). Although the opacification degree of maxillary sinuses in atopic patients showed no significant difference compared with that in non-atopic patients, maximum nasal mucosa thickening in atopic patients had a significant difference compared with that in non-atopic patients (p=0.028). In severe asthmatics, the opacification degree of maxillary sinuses was significantly more prominent compared with those in moderate and mild asthmatics (p=0.0005, p=0.036, respectively). Significantly marked nasal mucosa thickening was recognized in mild asthmatics compared with that in moderate asthmatics (p=0.0462). Regarding bronchial hyperresponsiveness, a significant correlation between Dmin and the opacification degree of maxillary sinuses was observed (rs= -0.551, p=0.0276). Nasal mucosa thickening had no correlation with bronchial hyperresponsiveness. The results suggest that sinusitis may affect bronchial hyperresponsiveness and asthma severity. Treatment of sinusitis may lead to improvement of asthma symptoms.
キーワード	気管支喘息 (bronchial asthma) 副鼻腔炎 (sinusitis) CT所見 (CT findings) 気道過敏性 (hyperresponsiveness)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	28
終了ページ	35
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308098

Evaluation of low attenliation area (LAA) of the lungs in patients with reversible airway obstruction by high resolution computed tomography (HRCT).

JaLCDOI	10.18926/14925
タイトル（別表記）	気管支喘息における胸部HRCT所見の臨床[光延文裕1]的意義
フルテキストURL	070_017_027.pdf
著者	光延文裕\| 御舩尚志\| 芦田耕三\| 保崎泰弘\| 柘野浩史\| 岡本誠\| 原田誠之\| 中井陸郎\| 谷崎勝朗\|
抄録	The significance of the low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) has not been determined in patients with asthma. We examined the relationship between the percentage of lung area with CT numbers lower than -950HU (% LAA) and the mean CT number in 81 patients with reversible airway obstruction (asthma) and in 22 healthy subjects, as well as the relationship between maximal % LAA and various parameters of pulmonary function, smoking history, disease severity and allergic type in the asthmatic subjects. The mean CT number was obtained by scans at three anatomic levels, and maximal % LAA was the % LAA which had the largest value of those measured at the three anatomic levels of the lung. We found that: 1. The mean CT number was closely related to the maximal % LAA of the lungs in all subjects studied (r= -0.916, p
キーワード	low attenuation area high resolution computed tomography reversible airway obstruction
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	17
終了ページ	27
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308175

IgE-mediated allergy enhances and glucocorticoids inhibit the generation of leukotrienes B4 and C4 by peripheral leucocytes in patients with asthma

JaLCDOI	10.18926/14922
タイトル（別表記）	Ⅰ型アレルギー反応および副腎皮質ホルモンは気管支喘息における末梢血白血球のロイコトリエンB4およびC4産生に影響をおよぼす
フルテキストURL	070_009_016.pdf
著者	谷崎勝朗\| 光延文裕\| 御舩尚志\| 保崎泰弘\| 芦田耕三\| 柘野浩史\| 岡本誠\| 原田誠之\| 高田真吾\| 越智浩二\| 小出典男\|
抄録	The generation. of leukotrienes 84 (LT84) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 71 patients with asthma (42 with atopic and 29 with nonatopic asthma) and 23 healthy controls. Of these patients,22 had SDIA (steroid-dependent intractable asthma). 1. The generation of LT84 and LTC4 by leucocytes was significantly more enhanced in patients with atopic, non-SOIA asthma than in healthy subjects, but not in patients with nonatopic asthma. The generation of LT84 and LTC4 in atopic asthma was significantly more decreased in patients with SOIA than in those with non-SOIA. 2. The LTC4 generation was significantly larger in attack stage than in attack-free stage of patients with atopic and nonatopic asthma when they had not SOIA. However, no significant difference was found in LT84 generation between attack and nonattack stages in these patients. 3. In patients with SOIA, no significant differences were observed in the generation of LT84 and LTC4 between attack and nonattack stages. The results suggest that IgE-mediated allergy and asthma attacks enhance and glucocorticoids inhibit the generation of LT84 and LTC4 by leucocytes.
キーワード	bronchial asthma LT84 LTC4 IgE-mediated allergy glucocorticoids
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	9
終了ページ	16
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308654

Matrix metalloproteinases (MMPs) and pancreatic diseases

JaLCDOI	10.18926/14913
タイトル（別表記）	マトリックスメタロプロテアーゼと膵疾患
フルテキストURL	071_076_083.pdf
著者	横山元浩\| 越智浩二\| 水島孝明\| 一村光子\| 鶴見哲也\| 光延文裕\| 谷崎勝朗\|
抄録	Matrix metalloproteinases (MMPs) is a family of collagenolytic enzymesand are associated with many pathological conditions. Especially, MMPs have a strong relation with tumor progression and invasion. In this review, we focused on association of MMPs and pancreatic diseases, and a potential treatment of MMPs inhibitors for pancreatic cancer.
キーワード	matrix metalloproteinase(MMP) tissue inhibitor of metalloproteinase(TIMP) pancreatic cancer (膵癌) chronic pancreatitis (慢性膵炎)
出版物タイトル	岡大三朝分院研究報告
発行日	2001-02-01
巻	71巻
開始ページ	76
終了ページ	83
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308587

Glucocorticoid-induced cortical bone porosity in postmenopausal patients with asthma

JaLCDOI	10.18926/14910
タイトル（別表記）	ステロイド依存性気管支喘息症例の病的骨折と皮質骨傷害の検討
フルテキストURL	071_059_067.pdf
著者	柘野浩史\| 後藤文禮\| 中井睦郎\| 岡本誠\| 高田真吾\| 御舩尚志\| 保﨑泰弘\| 光延文裕\| 芦田耕三\| 穐山恒雄\| 辻孝夫\| 谷崎勝朗\|
抄録	In a previous study, we demonstrated that chronic administration of systemic glucocorticoids decreases cortical bone mineral density (BMD) and induces development of pathologic fractures in asthmatic patients. To investigate cortical bone porosity due to glucocorticoids, we studied cortical bone volume, BMD, bone strength, and fractures in patients with asthma in this report. A total of 82 postmenopausal asthmatic patients were enrolled in the study. Vertebral fractures were diagnosed via plain spinal radiograms. Peripheral quantitative computed tomography (pQCT) was used to measure cortical BMD, relative cortical volume, and Strength Strain Index (SSI). Multiple regression analysis, Student's t test, and other statistical analyses were performed. Patients with systemic glucocorticoids therapy had lower cortical BMD, relative cortical volume, SSI, and more number of vertebral fractures than patients without it. Lifetime cumulative dose of glucocorticoids was related to cortical BMD, relative cortical volume, SSI, and the number of vertebral fractures. The cortical volumedensity relationship appeared to remain constant regardless of systemic glucocorticoid administration. The number of vertebral fractures correlated highly with cortical BMD, relative cortical volume, and SSI at the radius. In conclusion, systemic glucocorticoid administration decreases cortical bone density, cortical bone volume, and bone strength. G lucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites. Given that both cortical bone density and volume provide bone strength, cortical bone porosity was seen to contribute to glucocorticoid - induced bone strength loss and fractures.
キーワード	glucocorticoid cortical bone pQCT osteoporosis
出版物タイトル	岡大三朝分院研究報告
発行日	2001-02-01
巻	71巻
開始ページ	59
終了ページ	67
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308222

Effects of dietary supplementation with n－3 fatty acidson bronchial asthma associated with changes in lipids．－Comparison with n－6 fatty acids－

JaLCDOI	10.18926/14909
タイトル（別表記）	脂肪の変化と関連した気管支喘息に対するn－3系脂肪酸食の効果 ― n－6系脂肪酸との比較
フルテキストURL	071_050_058.pdf
著者	岡本誠\| 光延文裕\| 芦田耕三\| 御舩尚志\| 保﨑泰弘\| 柘野浩史\| 高田真吾\| 谷崎勝朗\| 原田実根\|
抄録	N-3 fatty acids have been reported to be effective for asthma. In the present study, the effects of perilla seed oil (n-3 fatty acids) on asthma were compared with the effects of corn oil (n-6 fatty acids) in terms of pulmonary function, lipometabolism and the generation of leukotriene C4 (LTC4) by leucocytes. A total of 28 asthmatic patients were randomly divided into two groups : Group A patients (15 subjects) consumed perilla seed oil-rich supplementation, while Group B patients (13 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTC4 by leucocytes, respiratory function and the serum levels of lipids were compared between the two groups. The generation of LTC4 by leucocytes decreased significantly in Group A subjects following perilla seed oil-rich supplementation for 2(P < 0.05) and 4 weeks(P < 0.01). A significant difference in the generation of LTC4 was observed between the two groups after different dietary supplementations for 4 weeks (P < 0.05). Significantly increased values for PEF (P < 0.01), FVC (P < 0.05) and FEV1.0 (P < 0.05) were found in Group A subjects following perilla seed oil supplementation for 4 weeks, compared with the initial value prior to supplementation. A significant decrease in the serum level of total cholesterol, LDL-cholesterol and phospholipid was detected in Group A subjects following perilla seed oil supplementation for 4 weeks. The present results suggest that peril la seed oil-rich supplementation is effective in the treatment of asthma in terms of its ability to suppress LTC4 generat ion by leucocytes, and in inducing an improvement in pulmonary function associated with changes in the serum level of lipids.
キーワード	perilla seed oil (エゴマ抽) a -1inolenic acid (α－リノレン酸) leukotriene C4 (ロイコトリエンC4) respiratory function (呼吸機能) 脂質代謝
出版物タイトル	岡大三朝分院研究報告
発行日	2001-02-01
巻	71巻
開始ページ	50
終了ページ	58
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308088

Correlation between efficacy of Pranlukast and LTC4 generation by peripheral leukocytes

JaLCDOI	10.18926/14907
タイトル（別表記）	気管支喘息症例における末梢血白血球のロイコトリエンC4産生能とロイコトリエン受容体括抗薬プランルカストの効果に関する検討
フルテキストURL	071_036_041.pdf
著者	御舩尚志\| 高田真吾\| 岡本誠\| 柘野浩史\| 芦田耕三\| 光延文裕\| 保﨑泰弘\| 谷崎勝朗\| 原田実根\|
抄録	The correlation between the efficacy of 4-weeks administration with pranlukast, leukotriene receptor antagonist, and LTs generation by peripheral leukocytes were evaluated in 18 patients with mild-persistent asthma. The efficacy of pranlukast administration was assessed by symptom, morning PEF and pulmonary function. Pranlukast were effective in 12/18(67%) patients. In those patients, LTC4 generation before pranlukast administration was significantly high, compared with that in pranlukast-ineffective patients. LTC4 generation decreased after 4-weeks administration with pranlukast in effective patients. In ineffective patients, however, LTC4 generation increased after 4-weeks administration. LTB4 had shown no significant difference between effective and ineffective patients before administration, and LTB4 decreased after 4-weeks in both groups. Proport ion of peripheral eosinophi Is in effective patients were higher than that in ineffective patients, however not significant. After 4-weeks, proportion of eosinophi Is was decreased in effective patients and increased in ineffective patients. These findings suggest that pranlukast is effective for patients with high LTC4 generation and has the effect to suppress the accumulation of eosinophils in such patients.
キーワード	bronchial asthma pranlukast leukotriene receptor antagonist LTC4
出版物タイトル	岡大三朝分院研究報告
発行日	2001-02-01
巻	71巻
開始ページ	36
終了ページ	41
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308269

Correlation between pulmonary function and low attenuation area (LAA) on HRCT III patients with asthma in relation to smoking

JaLCDOI	10.18926/14906
タイトル（別表記）	気管支喘息患者における肺機能とHRCT上のlow attenuation areaに対する喫煙の影響
フルテキストURL	071_029_035.pdf
著者	光延文裕\| 御舩尚志\| 保﨑泰弘\| 芦田耕三\| 柘野浩史\| 岡本誠\| 高田真吾\| 横井正\| 谷崎勝朗\|
抄録	The influence of smoking on pulmonary function and emphysematous changes of the lung (percentage of attenuation area < -950 HU (% LAA) on high resolution computed tomography (HRCT) was examined in 49 patients with bronchial asthma. 1. In patients with asthma, the % residual volume (RV) in many nonsmokers was less than 129%, in contrast, the % RV in many smokers was between 130% and 189% , which was higher than that in nonsmokers. 2. Significant correlations between % RV and 96LAA value, and between % RV and CT number were observed both in nonsmokers and smokers with asthma, in which as % RV more increased, % LAA value was larger, and CT number was lower. 3. % DLco value was lower in smoking patients with asthma, whose % RV was between 130% and 189% and larger than 190% , however, the % DLco value did not change in nonsmoking patients despite of higher valure in % RV. 4. A significant correlation was also observed between % FEV1.0 value and % RV both in smoking and nonsmoking patients with asthma; as % RV value more increased, % FEV1.0 value was lower. 5. Any correlation between % FVC value and % RV was not observed. These results suggest that smoking affects the % LAA of the lung on HRCT and % DLco in patients with asthma.
キーワード	asthma smoking % LAA of the lungs FEV1.0 DLco
出版物タイトル	岡大三朝分院研究報告
発行日	2001-02-01
巻	71巻
開始ページ	29
終了ページ	35
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308294

Quantitative evaluation by high resolution computed tomography (HRCT) of patients with asthma and emphysema

JaLCDOI	10.18926/14905
タイトル（別表記）	胸部高分解能CT（HRCT）による肺野low attenuation area（LAA）の定量的評価　―気管支喘息および肺気腫症例の比較検討―
フルテキストURL	071_019_028.pdf
著者	光延文裕\| 御舩尚志\| 芦田耕三\| 保﨑泰弘\| 柘野浩史\| 岡本誠\| 原田誠之\| 中井睦郎\| 谷崎勝朗\|
抄録	Background: Assessment of low attenuation areas and lung densitometry on high resolution computed tomography (HRCT) have been reported in studies of patients with chronic obstructive pulmonary disease. Objective : The purpose of this study was to examine if HRCT could separate asthmatic patients from normal control subjects and patients with emphysema. Methods : Subjects were divided into three groups : 24 patients with bronchial asthma, 23 patients with pulmonary emphysema and 15 normal controls. HRCT scans of the lung were performed at three different levels at both end inspiration and expiration in all patients and control subjects. Results : The mean CT number of three slices was significantly lower in asthmatic subjects compared with normal individuals at both end inspiration (p < 0.05) and expiration (p < 0.01). The relative area of the lung with an attenuation value lower than -950 HU (% LAA) for three slices was significantly higher in asthmatic subjects than in normal individuals at end inspiration (p < 0.05), but there was no significant difference at end expiration. The mean CT number and % LAA obtained from studies that were performed at three cm above the top of the diaphragm provided the best separation among three anatomic levels. In comparison between asthmatic and emphysema patients, both parameters were significantly different in asthmatic subjects than in those with emphysema at both end inspiration and expiration on each scan and in the total scans (p < 0.001). Conclusions : HRCT is a useful method to separate asthmatic subjects from patients with emphysema and normal subjects.
キーワード	HRCT asthma emphysema
出版物タイトル	岡大三朝分院研究報告
発行日	2001-02-01
巻	71巻
開始ページ	19
終了ページ	28
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308115

Spa therapy and bronchial hyperresponsiveness in elderly patients with asthma

JaLCDOI	10.18926/14904
タイトル（別表記）	高齢者気管支喘息における気道過敏性と温泉療法
フルテキストURL	071_010_018.pdf
著者	谷崎勝朗\| 光延文裕\| 御舩尚志\| 保﨑泰弘\| 芦田耕三\| 柘野浩史\| 岡本誠\| 高田真吾\| 越智浩二\|
抄録	Clinical effects of spa therapy were examined in 150 patients with asthma in relation tobronchial hyperresponsiveness and patient age. 1. The efficacy rate of spa therapy was larger as the patient age was higher: the rate was 73.3% in patients under age 49, 81.8% in those between the ages of 50 and 59, 86.4% in those between the ages of 60 and 69, and 90.6% in those over age 70. The mean of efficacy rates was 83.3% in all subjects. 2. The bronchial hyperresponsiveness (BH) was lower as patient age was higher: the BH in patients between the ages of 60 and 69 and in those over age 70 was significantly lower compared to the BH in those under age 49 (p < O.OOl). 3. Clinical effects of spa therapy tended to be lower in patients with increased bronchial hyperresponsiveness. The bronchial hyperresponsiveness showed a tendency to decrease after spa therapy in whom the therapy was effective, however, the BH did not change in patients with slight or no efficacy during spa therapy.
キーワード	spa therapy asthma bronchial hyperresponsiveness patient age
出版物タイトル	岡大三朝分院研究報告
発行日	2001-02-01
巻	71巻
開始ページ	10
終了ページ	18
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308660

A case with persistent asthma symptoms despite fluticasone treatment in which concomitant treatment with montelukast and perilla seed oil-rich supplementation significantly improved asthma control

JaLCDOI	10.18926/14900
タイトル（別表記）	Fluticasone 投与にもかかわらず症状が軽快ぜすn-3系不飽和脂肪酸強化食による食事療法及びモンテルカストが著効した気管支喘息の１例
フルテキストURL	076_053_059.pdf
著者	高田真吾\| 芦田耕三\| 保崎泰弘\| 濱田全紀\| 岩垣尚史\| 菊池宏\| 光延文裕\|
抄録	A 25-year-old woman had the chief complaint of recurrent episodes of dyspnea and wheeze. Asthma had been diagnosed at infant years and sometimes experienced asthma attacks. She graduated senior high school and entered technical school in Tokyo. She received fluticasone (400μg daily) but exacerbation continued after she became an office clerk. She returned Kurashiki in October 2001 but had wheeze and asthma exacerbations. She was admitted to our hospital for evaluation and treatment of bronchial asthma on August 2, 2002. After admission, her symptoms subsided within some days. She was treated with montelukast and perilla seed oil-rich supplementation . The number of eosinophils decreased, decrease was observed in leukotriene (LT) B4 generation and in LTC4 generation, and pulmonary function improved following montelukast and perilla seed oil-rich supplementation for 4 weeks. The patient had no exacerbation under treatment and was discharged from the hospital on September 2, 2002. For some patients with persistent asthma, inhaled corticosteroids may fail to achieve adequate control possibly because corticosteroids do not completely inhibit the synthesis and release of cysteinyl leukotrienes (cysLTs) in the lung. Montelukast blocks the interaction of cysLTs with their receptor and resulting downstream events and perilla seed oil-rich diet suppresses LT generation. Combination therapy with montelukast and perilla seed oil-rich diet is more effective than montelukast or perilla seed oil-rich diet alone because of additive effects of montelukast with perilla seed oil-rich diet. We suggest that montelukast and perilla seed oil-rich supplementation are effective options when bronchial asthma patients receive inhaled corticosteroid but exacerbation continues.
キーワード	モンテルカスト (montelukast) 気管支喘息 (bronchial asthma) ロイコトリエンC4 (leukotriene C4) エゴマ油食 (perilla seed oil-rich supplementation) フルチカゾン (fluticasone)
出版物タイトル	岡大三朝医療センター研究報告
発行日	2008-03-01
巻	76巻
開始ページ	53
終了ページ	59
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308179

Effects of spa therapy on the six-minute walk test in patients with chronic obstructive pulmonary disease

JaLCDOI	10.18926/14895
タイトル（別表記）	慢性閉塞性肺疾患患者における温泉療法の６分間歩行に対する効果
フルテキストURL	076_024_030.pdf
著者	高田真吾\| 芦田耕三\| 保崎泰弘\| 濱田全紀\| 岩垣尚史\| 菊池宏\| 光延文裕\|
抄録	Our previous studies have shown that subjective symptoms and ventilatory function are improved by spa therapy in patients with chronic obstructive pulmonary disease (COPD). In the present study, we investigated the effects of spa therapy on six-minute walk distance in patients with COPD . Subjects were 10 patients with chronic obstructive pulmonary disease (9 males and 1 female) admitted to our hospital to undergo pulmonary rehabilitation. All patients had complex spa therapy (swimming training in a hot spring pool, inhalation of iodine salt solution, and fango therapy) for 4 weeks. Ventilatory function, six-minute walk distance, oxygen saturation and Borg scale were measured. Vital capacity, forced expiratory volume in one second, sixminute walk distance and oxygen saturation increased, but not significantly. Significant decreases were observed for Borg scale. We found that spa therapy improved ventilatory dysfunction and six-minute walk distance in patients with COPD. The results demonstrated that spa therapy may lead to better disease control and exercise tolerance in patients with COPD.
キーワード	Chronic obstructive pulmonary disease (慢性閉塞性肺疾患) Spa therapy (温泉療法) Six-minute walk test (６分間歩行試験) Borg scale (ボルグスケール) Ventilatory function (呼吸機能)
出版物タイトル	岡大三朝医療センター研究報告
発行日	2008-03-01
巻	76巻
開始ページ	24
終了ページ	30
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308319