検索結果 1339 件
| JaLCDOI | 10.18926/14974 |
|---|---|
| タイトル（別表記） | 気管支喘息におけるCTによる気腫性変化｡喫煙症例と非喫煙症例の比較｡ |
| フルテキストURL | 068_008_014.pdf |
| 著者 | 谷崎 勝朗| 光延 文裕| 芦田 耕三| 御舩 尚志| 保崎 泰弘| 柘野 浩史| 岡本 誠| 岩垣 尚志| 山本 和彦| 中井 睦郎| 穐山 恒雄| |
| 抄録 | The percentage of attenuation area < -950HU (% LAA) on high resolution computed tomography (HRCT) was compared between 17 smoking and 24 nonsmoking patients with asthma. 1. FEV1/FVC value was lower in smoking patients (56.4%) than in nonsmoking patients (66.0%), however, the difference was not significant. 2. The percentage of LAA of the lung was larger in smoking patients compared with that in nonsmoking patients in all the three anatomic levels: the % LAA was 14.4% in nonsmoking and 20.3% in smoking patients at lower lung level (3cm above the top of the diaphragm). However, this was not significant. The maximal % LAA among the three lung levels on HRCT was 21.6±12.5% in smoking, and 15.7±11.9% in nonsmoking patients. This suggested that the maximal % LAA was larger in smoking patients, however, this was not significant. 3. The mean CT number of the lung on HRCT was smaller in smoking patients (-897.3HU) than in nonsmoking patients (-884.7HU). 4. Three of 4 nonsmoking patients whose % LAA was more than 30% had severe intractable asthma with long-term glucocorticoid therapy. The results suggest the possibility that smoking influences the % LAA of the lung on HRCT in asthma. It could be also speculated that % LAA is influenced by severity of asthma. |
| キーワード | bronchial asthma FEV1 % LAA mean CT number HRCT |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1997-12 |
| 巻 | 68巻 |
| 開始ページ | 8 |
| 終了ページ | 14 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308579 |
| JaLCDOI | 10.18926/14963 |
|---|---|
| タイトル（別表記） | サーモグラフィーによる体表面温度の測定 2.温水負荷の効果 |
| フルテキストURL | 069_068_075.pdf |
| 著者 | 保崎 泰弘| 高田 真吾| 光延 文裕| 御舩 尚志| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 谷崎 勝朗| 越智 浩二| 原田 英雄| 辻 孝夫| |
| 抄録 | The body surface temperature of 41 patients suffering coldness, numbness or pain in their feet was examined using thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as: Recovery ratio =[Total counts of thermography (Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). Three different baseline temperatures, 26℃. 27℃ and 28℃, were used in processing the thermographic results into pictures. The recovery ratio was susceptible to temperature, and we recommend a baseline temperature limitation of 27℃ for clinical study. A bi-modal distribution of recovery ratio was observed in 18 patients with diabetes mellitus. One group (6 subjects) had high recovery ratio between 80%-100%, and another group (10 subjects) had a low recovery ratio between 0%-19%. The results of thermography were also influenced by weather. To reduce the effect of outside temperature, we used pre-loading with hot water at 36℃ for 5 min (hot loading). A large difference in recovery ratio between presence and absence of hot loading was observed in 6 of the 30 subjects. The difference was over-estimated in more than 20% of recovery ratio without hot loading as compared with hot loading in these 6 subjects. The effect of drugs on peripheral circulation, such as beraprost sodium and sarpogrelate hydrochloride, was clear and quantified using thermography under these conditions of hot loading. |
| キーワード | サーモグラフィー (thermography) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading) 温水負荷 (hot loading) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1998-12 |
| 巻 | 69巻 |
| 開始ページ | 68 |
| 終了ページ | 75 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308316 |
| JaLCDOI | 10.18926/14962 |
|---|---|
| タイトル（別表記） | ステロイド依存性重症難治性気管支喘息症例における胃粘膜病変の検討 |
| フルテキストURL | 069_063_067.pdf |
| 著者 | 御舩 尚志| 光延 文裕| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 原田 誠之| 岡本 誠| 湯本 英一朗| 高田 真吾| 谷崎 勝朗| |
| 抄録 | Recently, we experienced two asthmatic patients with advanced gastric cancer. The two patients had steroid-dependent intractable asthma (SDIA) who had been on administration of corticosteroids for more than 2 years. To determine the influence of pathophysiology of SDIA on stomach mucous lesion, gastroscopic examinations and immunological examinations were performed in eight patients with SDIA, compared with 25 patient with non-SDIA. In patients with SDIA, gastric cancer, its precursor condition and immunosuppressive state were observed. These results suggest that the immunosuppressive state in SDIA induced by the long-term administration of corticosteroids may lead to the risk of gastric cancer development. |
| キーワード | ステロイド依存性重症難治性 (steroid-dependent intractable asthma (SDIA)) 胃癌 (gastric cancer) 免疫抑制 (immunosuppression) リンパ球 (lymphocytes) IgG |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1998-12 |
| 巻 | 69巻 |
| 開始ページ | 63 |
| 終了ページ | 67 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308665 |
| JaLCDOI | 10.18926/14959 |
|---|---|
| タイトル（別表記） | n-3系脂肪酸食の気管支喘息に対する臨床効果:n-6系脂肪酸との比較 |
| フルテキストURL | 069_040_048.pdf |
| 著者 | 岡本 誠| 芦田 耕三| 光延 文裕| 御舩 尚志| 保崎 泰弘| 柘野 浩史| 原田 誠之| 湯本 英一朗| 高田 真吾| 谷崎 勝朗| 片岡 幹男| 原田 実根| |
| 抄録 | N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma by suppressing leukocyte function, followed by reduction of the need for pharmacologic agents. To examine the effects of dietary supplementation with perilla seed oil rich in α-linolenic acid (ALA), 23 patients with asthma took corn oil rich in linoleic acid (LA) for the former two weeks, perilla seed oil for the later two weeks. The asthmatic patients were classified into two groups by the changes of the generation of leukotrienes B4 (LTB4), C4 (LTC4), and B5 (LTB5) during the two courses of dietary modification: one was sensitive to dietary modification, and the other was insensitive to dietary supplementation. We compared the two groups in clinical characteristics. Significant differences were observed in peak flow (PEF), forced expiratory volume in one second (FEV1.0), IgE, sex, obesity index (OI), concentration of serum total cholesterol, albumin, low density lipoprotein {LDL)-cholesterol, β-lipoprotein and phospholipids between two groups. This study indicated that these factors influence the generation of LTB4, C4 and B5 of asthmatic patients in dietary supplementation. |
| キーワード | n-3系脂肪酸 (n-3 fatty acids) エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) LTB4 LTC4 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1998-12 |
| 巻 | 69巻 |
| 開始ページ | 40 |
| 終了ページ | 48 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308199 |
| JaLCDOI | 10.18926/14953 |
|---|---|
| タイトル（別表記） | 肺気腫患者におけるロイコトリエンB4,C4産生能と高分解能CTによる平均CT値との関連 |
| フルテキストURL | 069_015_020.pdf |
| 著者 | 光延 文裕| 御舩 尚志| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 湯本 英一郎| 高田 真吾| 越智 浩二| 原田 英雄| 長谷川 晴巳| |
| 抄録 | The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leukocytes stimulated with Ca ionophore A23187 was examined in 17 patients with pulmonary emphysema. They were divided into three groups according to the mean CT number; A (<-940 HU), B (-940 ≦, <-930 HU), and C (-930 HU ≦ ).1. The values of FVC (% predicted), FEV1.0% and DLco (% predicted) showed a tendency to decrease as the mean CT number was smaller. The value of % FVC was significantly lower in patients with group A than in those with group C (p<0.05). 2. The generation of both LTB4 and LTC4 was significantly higher in patients with emphysema compared to the generation in healthy subjects (LTB4;p<0.05, LTC4;P<0.05). 3. The generation of LTB4 and LTC4 in patients with emphysema was higher as the mean CT number was larger (severity of the disease become less). The LTC4 production was significantly higher in patients with group C(mild or moderate type of emphysema) than in those with group A(advanced type of emphysema). These results suggest that the generation of LTB4 and LTC4 is higher in patients with mild or moderate type of emphysema than in those with advanced type of the disease. |
| キーワード | emphysema mean CT number LTB4 LTC4 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1998-12 |
| 巻 | 69巻 |
| 開始ページ | 15 |
| 終了ページ | 20 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308094 |
| JaLCDOI | 10.18926/14950 |
|---|---|
| タイトル（別表記） | Clinical significance of spa therapy in the treatmentof patients with chronic obstructive pulmonary disease (COPD). A study on 511 patients with COPD admitted for last 5 years |
| フルテキストURL | 069_001_008.pdf |
| 著者 | 谷崎 勝朗| 光延 文裕| 御舩 尚志| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 湯本 英一郎| 高田 真吾| 越智 浩二| 原田 英雄| |
| 抄録 | 1993年1月より1997年12月までの5ヵ年間に当院へ入院した慢性閉塞性呼吸器疾患511例を対象に,疾患の種類,年齢,地域分布などについて検討を加えた｡1.最近5年間に当院へ入院した呼吸器疾患患者は594例で,このうち,慢性閉塞性呼吸器疾患患者は511例(86.0%)であった｡これらの慢性閉塞性呼吸器疾患のなかでは,気管支喘息が416例(81.4%)と最も多く,その他.慢性気管支炎20例,閉塞性細気管支炎27例,肺気腫48例であった｡2.慢性閉塞性呼吸器疾患のなかでは,肺気腫の症例が増加する傾向が見られた｡3.慢性閉塞性呼吸器疾患の年齢別検討では,鳥取県内では,70才以上の症例が,また遠隔地(鳥取県外)では60-69才の症例の頻度が高い傾向が見られた｡4.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,その比率は1997年度で48.4%であった｡また,その分布別検討では,岡山県,兵庫県,大阪府,広島県,山口県,愛媛県からの入院患者が多い傾向が見られた｡ |
| キーワード | 慢性閉塞性呼吸器疾患 (COPD) 気管支喘息 (bronchial asthma) 温泉療法 (spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1998-12 |
| 巻 | 69巻 |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002308114 |
| JaLCDOI | 10.18926/14944 |
|---|---|
| タイトル（別表記） | Clincal evaluation of spa effects for patients with respiratory disease and chronic pain disease |
| フルテキストURL | 070_088_092.pdf |
| 著者 | 西村 伸子| 寺崎 佳代| 山本 貞枝| 中村 寿美江| |
| 抄録 | 1998年1月より12月までの1年間に,温泉療法-主として温泉プール水泳ないし歩行訓練及び鉱泥湿布治療-を受けた158例の入院症例(呼吸器疾患78例,疼痛性疾患64例,その他16例)について退院時に臨床効果を5段階で評価してもらいそれぞれの入院期間との比較検討を行った｡対象症例の年齢は70才代が最も多く,次いで60才代,50才代,80才代であった｡地域分布では,鳥取県外の入院症例が72.2%を占め,県外である遠隔地としては,岡山県,兵庫県,広島県,大阪府,東京都,神奈川県からの入院が多く見られた｡臨床効果は,"非常に良くなった"と,"かなり良くなった"を有効と判定し,その有効率は呼 吸器疾患では78.2%であった｡一方,疼痛性疾患では,その有効率は50.0%であったが,"少し良くなった"症例を含めると,95.3%,その他の症例は68.8%であった｡入院期間別に検討すると,呼吸器疾患では入院1ケ月で72.7%,2ケ月では81.8%,3ケ月以上では76.5%であった｡一方,疼痛性疾患では,入院1ケ月で21.1%,2ケ月で60.0%,3ケ月で64.0%であり,呼吸器疾患と比べ,効果出現までの期間がやヽ長く,入院期間が長くなるほど,その効果は高くなる傾向が見られた｡ |
| キーワード | 温泉療法 (spa therapy) 呼吸器疾患 (respiratory disease) 慢性疼痛性疾患 (chronic pain disease) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1999-12 |
| 巻 | 70巻 |
| 開始ページ | 88 |
| 終了ページ | 92 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002308358 |
| JaLCDOI | 10.18926/14934 |
|---|---|
| タイトル（別表記） | 気管支喘息症例における皮質骨海綿化 |
| フルテキストURL | 070_053_060.pdf |
| 著者 | 柘野 浩史| 中井 睦郎| 岡本 誠| 原田 誠之| 高田 真吾| 御舩 尚志| 光延 文裕| 芦田 耕三| 保崎 泰弘| 穐山 恒雄| 辻 孝夫| 谷崎 勝朗| |
| 抄録 | In previous studies, we have demonstrated that chronic administration of systemic glucocorticoids decreases cortical bone mineral density (BMD), cortical bone volume, bone strength, and induces development of pathologic fractures in asthmatic patients. We have also demonstrated that glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites in postmenopausal asthmatic patients. There is a difference of gonadal hormones between male and female. To investigate the influence of hormonal difference on glucocorticoid-induced cortical bone porosity, we studied cortical bone volume and BMD in both male and female patients with asthma in this report. A total of 99 asthmatic patients (male 26 cases, female 73 cases) were enrolled in the study. Peripheral quantitative computed tomography (pQCT) was used to measure cortical BMD and relative cortical volume. The cortical volume-density relationship appeared to remain constant regardless of the level of systemic glucocorticoid administration, age or sex, suggesting cortical bone porosity causes similar and simultaneous decreases in cortical bone volume and density. In conclusion, glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites despite the gonadal hormonal differences. |
| キーワード | bronchial asthma systemic glucocorticoid cortical bone cortical porosity peripheral quantitative computed tomography |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1999-12 |
| 巻 | 70巻 |
| 開始ページ | 53 |
| 終了ページ | 60 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308477 |
| JaLCDOI | 10.18926/14933 |
|---|---|
| タイトル（別表記） | 気管支喘息患者における白血球ロイコトリエン産生能に対する不飽和脂肪酸食の効果に影響する因子 |
| フルテキストURL | 070_043_052.pdf |
| 著者 | 岡本 誠| 光延 文裕| 芦田 耕三| 御舩 尚志| 保崎 泰弘| 柘野 浩史| 原田 誠之| 高田 真吾| 谷崎 勝朗| 片岡 幹男| 新谷 憲治| 原田 実根| |
| 抄録 | Dietary supplementation with perilla seed oil, a vegetable oil rich in α -lin- olenic acid, inhibits the generation of leukotrienes(LTs) by leucocytes in patients with bronchial asthma. We examined the factors that affect the suppression of LT generation by leucocytes with perilla seed oil-rich supplementation in patients with asthma, by comparing the clinical features of patients with asthma, whose generation of leukotriene (LT) C4 was suppressed by dietary supplementation with perilla seed oil (n-3 fatty acids) (group A), with those of patients who showed no suppression of LTC4 generation (group B). Group A showed a significant increase in the generation of LTB4 and L TC4 by leucocytes after corn oil-rich supplementation (n-6 fatty acids), and a significant decrease in the generation of LTB4 and LTC4 after perilla seed oil-rich supplementation (n-3 fatty acid). However, this was not observed in group B. The level of serum IgE and peak expiratory flow (PEF) in group A were significantly higher than in group B. Furthermore, the serum levels of LDL-cholesterol, β-lipoprotein and phospholipid were significantly lower in group A than in group B. These results suggest that the clinical features differ between these two asthmatic populations with respect to suppression of LTB4 and LTC4 generation by n-3 fatty acids in perilla seed oil-rich supplementation. |
| キーワード | エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) ロイコトリエン (leukotrienes) IgE 脂質代謝 (lipometabolism) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1999-12 |
| 巻 | 70巻 |
| 開始ページ | 43 |
| 終了ページ | 52 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308623 |
| JaLCDOI | 10.18926/OER/14931 |
|---|---|
| タイトル（別表記） | Evaluation Criteria for Investment Project − Comparison between Quadratic Utility Function and Other Methods − |
| フルテキストURL | 40_4_073_091.pdf |
| 著者 | 小山 泰宏| |
| 抄録 | The purpose of this article is to clarify the usefulness of quadratic utility function in evaluating investment projects. In the field of corporate finance, the standard technique used to evaluate proposed investment projects is capital asset pricing model and its graphed security market line. According to CAPM, the market risk is the risk to be quantified as risk premium in estimating the cost of equity capital. CAPM assumes that marginal and important investors are well−diversified institutional investors like pension funds, insurance companies and investment funds. To such investors, private risk of each project is negligible, because it is diversifiable. However, many top management in Japan believes that other stakeholders like employee, commercial banks, suppliers and etc are equally important. Their loyalty and contribution to the company is a vital factor to the success of company. Their fate or success becomes dependent on the growth and viability of the company, as they often commit their resource to the company for life or for a long period of time. In this case, Japanese top management should try to maintain and strengthen their long−term sustainability, which is more important than the short−term increase of shareholders wealth. In this context, evaluating proposed investment projects, private as well as market risk should be included with equal importance in calculating the total risk. In this article, I tried to compare such technique as SML (CAPM), Capital Market Line and quadratic utility function and clarified their difference in their evaluation results. CML and quadratic utility function are useful in evaluating private and total risk of investment projects, because their formula, different from other utility functions, contain the standard deviation to represent investment risk. Quadratic utility function seems to be a proper method in evaluating the investment project which involves unique or different type of business risk and requires relatively huge amount of investment. Dealing with utility function, I demonstrated to quantify utility value in terms of absolute amount of money rather than indicating the value in commonly used percentage. This would enable us to compare with the other traditional technique of net present value. |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2009-03-10 |
| 巻 | 40巻 |
| 号 | 4号 |
| 開始ページ | 73 |
| 終了ページ | 91 |
| ISSN | 0386-3069 |
| 言語 | 日本語 |
| 著作権者 | 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120002308573 |
| JaLCDOI | 10.18926/14927 |
|---|---|
| タイトル（別表記） | サーモグラフィーによる体表面温度の測定 3.体表面温度の回復率と末消血流量との相関 |
| フルテキストURL | 070_036_042.pdf |
| 著者 | 保崎 泰弘| 高田 真吾| 光延 文裕| 御舩 尚志| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 谷崎 勝朗| 越智 浩二| 辻 孝夫| |
| 抄録 | The body surface peripheral circulation in 12 cases, including 9 patients with diabetes mellitus who were suffering coldness, numbness or pain in their feet, and 3
healthy volunteers was examined using Laser-Doppler blood flowmetry. At the same time, the body surface temperature was estimated by thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio = [Total counts of thermography(Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). The recovery ratio and the blood flow were correlated, r=0.68, p |
| キーワード | サーモグラフィー (thermography) レーザードプラー血流計 (Laser-Doppler blood flowmetry) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1999-12 |
| 巻 | 70巻 |
| 開始ページ | 36 |
| 終了ページ | 42 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308240 |
| JaLCDOI | 10.18926/14925 |
|---|---|
| タイトル（別表記） | 気管支喘息における胸部HRCT所見の臨床[光延文裕1]的意義 |
| フルテキストURL | 070_017_027.pdf |
| 著者 | 光延 文裕| 御舩 尚志| 芦田 耕三| 保崎 泰弘| 柘野 浩史| 岡本 誠| 原田 誠之| 中井 陸郎| 谷崎 勝朗| |
| 抄録 | The significance of the low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) has not been determined in patients with asthma. We examined the relationship between the percentage of lung area with CT numbers lower than -950HU (% LAA) and the mean CT number in 81 patients with reversible airway obstruction (asthma) and in 22 healthy subjects, as well as the relationship between maximal % LAA and various parameters of pulmonary function, smoking history, disease severity and allergic type in the asthmatic subjects. The mean CT
number was obtained by scans at three anatomic levels, and maximal % LAA was the % LAA which had the largest value of those measured at the three anatomic levels of the lung.
We found that: 1. The mean CT number was closely related to the maximal % LAA of the lungs in all subjects studied (r= -0.916, p |
| キーワード | low attenuation area high resolution computed tomography reversible airway obstruction |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1999-12 |
| 巻 | 70巻 |
| 開始ページ | 17 |
| 終了ページ | 27 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308175 |
| JaLCDOI | 10.18926/14921 |
|---|---|
| タイトル（別表記） | Spa therapy for patients with asthma. A study on 437 patients with asthma admitted for last 5 years. |
| フルテキストURL | 070_001_008.pdf |
| 著者 | 谷崎 勝朗| 光延 文裕| 御舩 尚志| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 高田 真吾| 越智 浩二| |
| 抄録 | 1994年1月より1998年12月までの5年間に当院へ入院した呼吸器疾患のなかで気管支喘息を対象に,年齢,地域分布などの経年変化について検討を加えた｡1.最近5年間に当院へ入院した呼吸器疾患患者は664例で,このうち,気管支喘息は437例(65.8% )であった｡呼吸器疾患のなかで気管支喘息に占める割合の経年変化では,1995年度が最も高く(74.4% ),1997,1998年度にはやや低下(ともに60.7% )の傾向が見られた｡2.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,いずれの年度においても50% 以上(平均57.3% )であった｡また,岡山,大阪,兵庫,広島,山口,愛媛県などからの入院症例が多い傾向か見られた。3.年齢別検討では,いずれの地域においても,高齢者の入院症例か多く,鳥取県内では70才以上の症例の頻度(平均35.1% )が,また遠隔地(鳥取県外)では60-69才の症例の頻度(平均37.7% )が高い傾向か見られた｡ |
| キーワード | 気管支喘息 (asthma) 温泉療法 (spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1999-12 |
| 巻 | 70巻 |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002308420 |
| JaLCDOI | 10.18926/14915 |
|---|---|
| フルテキストURL | 071_089_093.pdf |
| 著者 | 石田 美枝子| |
| 抄録 | 通院患者の温泉プール利用者95名を対象にアンケート調査し，主に訓練に対する満足度と期待度について調査した。 結果は有効回答85名，対象者の年齢65歳以上58名（68％）65歳末満27名（32％），疾患別では呼吸器疾患39名（45．9％）療病性疾患29名（34．1％）その他の疾患17名（20％）であった。 t検定の結果有意差（P＜0．05）があったのは，療病性疾患群では呼吸器疾患群に比べ期待度が高い，訓練が頻回な群で期待度が高い，指導あり群で満足度が高い，であった。年齢別での効果では65歳末満と65歳以上の比較で有意差はなかったが，高齢者（65歳以上）において高い傾向が見られた。温泉プール訓練は高齢者に効果的な訓練と考えられ，より効果を高めるための課題として訓練指導を充実する必要がある。 |
| キーワード | 温泉プール訓練 外来通院患者 満足度 期待度 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 89 |
| 終了ページ | 93 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002308152 |
| JaLCDOI | 10.18926/14909 |
|---|---|
| タイトル（別表記） | 脂肪の変化と関連した気管支喘息に対するn－3系脂肪酸食の効果 ― n－6系脂肪酸との比較 |
| フルテキストURL | 071_050_058.pdf |
| 著者 | 岡本 誠| 光延 文裕| 芦田 耕三| 御舩 尚志| 保﨑 泰弘| 柘野 浩史| 高田 真吾| 谷崎 勝朗| 原田 実根| |
| 抄録 | N-3 fatty acids have been reported to be effective for asthma. In the present study, the effects of perilla seed oil (n-3 fatty acids) on asthma were compared with the effects of corn oil (n-6 fatty acids) in terms of pulmonary function, lipometabolism and the generation of leukotriene C4 (LTC4) by leucocytes. A total of 28 asthmatic patients were randomly divided into two groups : Group A patients (15 subjects) consumed perilla seed oil-rich supplementation, while Group B patients (13 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTC4 by leucocytes, respiratory function and the serum levels of lipids were compared between the two groups. The generation of LTC4 by leucocytes decreased significantly in Group A subjects following perilla seed oil-rich supplementation for 2(P < 0.05) and 4 weeks(P < 0.01). A significant difference in the generation of LTC4 was observed between the two groups after different dietary supplementations for 4 weeks (P < 0.05). Significantly increased values for PEF (P < 0.01), FVC (P < 0.05) and FEV1.0 (P < 0.05) were found in Group A subjects following perilla seed oil supplementation for 4 weeks, compared with the initial value prior to supplementation. A significant decrease in the serum level of total cholesterol, LDL-cholesterol and phospholipid was detected in Group A subjects following perilla seed oil supplementation for 4 weeks. The present results suggest that peril la seed oil-rich supplementation is effective in the treatment of asthma in terms of its ability to suppress LTC4 generat ion by leucocytes, and in inducing an improvement in pulmonary function associated with changes in the serum level of lipids. |
| キーワード | perilla seed oil (エゴマ抽) a -1inolenic acid (α－リノレン酸) leukotriene C4 (ロイコトリエンC4) respiratory function (呼吸機能) 脂質代謝 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 50 |
| 終了ページ | 58 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308088 |
| JaLCDOI | 10.18926/14907 |
|---|---|
| タイトル（別表記） | 気管支喘息症例における末梢血白血球のロイコトリエンC4産生能とロイコトリエン受容体括抗薬プランルカストの効果に関する検討 |
| フルテキストURL | 071_036_041.pdf |
| 著者 | 御舩 尚志| 高田 真吾| 岡本 誠| 柘野 浩史| 芦田 耕三| 光延 文裕| 保﨑 泰弘| 谷崎 勝朗| 原田 実根| |
| 抄録 | The correlation between the efficacy of 4-weeks administration with pranlukast, leukotriene receptor antagonist, and LTs generation by peripheral leukocytes were evaluated in 18 patients with mild-persistent asthma. The efficacy of pranlukast administration was assessed by symptom, morning PEF and pulmonary function. Pranlukast were effective in 12/18(67%) patients. In those patients, LTC4 generation before pranlukast administration was significantly high, compared with that in pranlukast-ineffective patients. LTC4 generation decreased after 4-weeks administration with pranlukast in effective patients. In ineffective patients, however, LTC4 generation increased after 4-weeks administration. LTB4 had shown no significant difference between effective and ineffective patients before administration, and LTB4 decreased after 4-weeks in both groups. Proport ion of peripheral eosinophi Is in effective patients were higher than that in ineffective patients, however not significant. After 4-weeks, proportion of eosinophi Is was decreased in effective patients and increased in ineffective patients. These findings suggest that pranlukast is effective for patients with high LTC4 generation and has the effect to suppress the accumulation of eosinophils in such patients. |
| キーワード | bronchial asthma pranlukast leukotriene receptor antagonist LTC4 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 36 |
| 終了ページ | 41 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308269 |
| JaLCDOI | 10.18926/14905 |
|---|---|
| タイトル（別表記） | 胸部高分解能CT（HRCT）による肺野low attenuation area（LAA）の定量的評価 ―気管支喘息および肺気腫症例の比較検討― |
| フルテキストURL | 071_019_028.pdf |
| 著者 | 光延 文裕| 御舩 尚志| 芦田 耕三| 保﨑 泰弘| 柘野 浩史| 岡本 誠| 原田 誠之| 中井 睦郎| 谷崎 勝朗| |
| 抄録 | Background: Assessment of low attenuation areas and lung densitometry on high resolution computed tomography (HRCT) have been reported in studies of patients with chronic obstructive pulmonary disease. Objective : The purpose of this study was to examine if HRCT could separate asthmatic patients from normal control subjects and patients with emphysema. Methods : Subjects were divided into three groups : 24 patients with bronchial asthma, 23 patients with pulmonary emphysema and 15 normal controls. HRCT scans of the lung were performed at three different levels at both end inspiration and expiration in all patients and control subjects. Results : The mean CT number of three slices was significantly lower in asthmatic subjects compared with normal individuals at both end inspiration (p < 0.05) and expiration (p < 0.01). The relative area of the lung with an attenuation value lower than -950 HU (% LAA) for three slices was significantly higher in asthmatic subjects than in normal individuals at end inspiration (p < 0.05), but there was no significant difference at end expiration. The mean CT number and % LAA obtained from studies that were performed at three cm above the top of the diaphragm provided the best separation among three anatomic levels. In comparison between asthmatic and emphysema patients, both parameters were significantly different in asthmatic subjects than in those with emphysema at both end inspiration and expiration on each scan and in the total scans (p < 0.001). Conclusions : HRCT is a useful method to separate asthmatic subjects from patients with emphysema and normal subjects. |
| キーワード | HRCT asthma emphysema |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 19 |
| 終了ページ | 28 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308115 |
| JaLCDOI | 10.18926/14903 |
|---|---|
| タイトル（別表記） | Spa therapy for 999 patients with respiratory disease admitted at Misasa Medical Branch for last 7 years |
| フルテキストURL | 071_001_009.pdf |
| 著者 | 谷崎 勝朗| 御舩 尚志| 光延 文裕| 保﨑 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 高田 真吾| 越智 浩二| |
| 抄録 | 1993年1月より1999年12月までの7年間に当院へ入院した呼吸器疾患999例のうち閉塞性換気障害を示す829例(気管支慌息BA+COPD)を対象に,年齢,地域分布などの経年変化について検討を加えた｡ 1.最近7年間に当院へ入院した閉塞性呼吸器疾患患者829例のうち, 気管支喘息は636例(76.7% )であった｡閉塞性呼吸器疾患のなかで気管支喘息の占める割合の経年変化では,1996年度が最も高く(84.5% )その後徐々に低下する傾向か見られ1999年度では65.5% であった｡一方′肺気腫は近年増加の傾向を示し,19993年度では5.6% であったが.1999年度では25.6% であった｡ 2.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,この7年間の鳥取県外(遠隔地)からの入院患者は829例中433例(52.2% )であった｡また,岡山,大阪,兵庫,広島,山口,愛媛,東京,神奈川などからの入院症例か多い傾向が見られた｡ 3.年齢別検討では,いずれの地域においても,高齢者の入院症例が多く,鳥取県内,県外を問わず,70才以上の症例の頻度が明らかに高い傾向か見られた.そして,50才以上の症例の全症例に対する頻度は,鳥取県内では80.9% ,県外では96.7% であり,県内ではその多くが,また県外ではそのほとんどが50才以上の症例であった｡ |
| キーワード | 気管支喘息 (asthma) 肺気腫 (pulmonary emphysema) 温泉療法 (Spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 1 |
| 終了ページ | 9 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002308210 |
| JaLCDOI | 10.18926/14895 |
|---|---|
| タイトル（別表記） | 慢性閉塞性肺疾患患者における温泉療法の６分間歩行に対する効果 |
| フルテキストURL | 076_024_030.pdf |
| 著者 | 高田 真吾| 芦田 耕三| 保崎 泰弘| 濱田 全紀| 岩垣 尚史| 菊池 宏| 光延 文裕| |
| 抄録 | Our previous studies have shown that subjective symptoms and ventilatory function are improved by spa therapy in patients with chronic obstructive pulmonary disease (COPD). In the present study, we investigated the effects of spa therapy on six-minute walk distance in patients with COPD . Subjects were 10 patients with chronic obstructive pulmonary disease (9 males and 1 female) admitted to our hospital to undergo pulmonary rehabilitation. All patients had complex spa therapy (swimming training in a hot spring pool, inhalation of iodine salt solution, and fango therapy) for 4 weeks. Ventilatory function, six-minute walk distance, oxygen saturation and Borg scale were measured. Vital capacity, forced expiratory volume in one second, sixminute walk distance and oxygen saturation increased, but not significantly. Significant decreases were observed for Borg scale. We found that spa therapy improved ventilatory dysfunction and six-minute walk distance in patients with COPD. The results demonstrated that spa therapy may lead to better disease control and exercise tolerance in patients with COPD. |
| キーワード | Chronic obstructive pulmonary disease (慢性閉塞性肺疾患) Spa therapy (温泉療法) Six-minute walk test (６分間歩行試験) Borg scale (ボルグスケール) Ventilatory function (呼吸機能) |
| 出版物タイトル | 岡大三朝医療センター研究報告 |
| 発行日 | 2008-03-01 |
| 巻 | 76巻 |
| 開始ページ | 24 |
| 終了ページ | 30 |
| ISSN | 1348-1258 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308319 |
| JaLCDOI | 10.18926/14894 |
|---|---|
| タイトル（別表記） | Examination about the effectiveness of thermal therapy on exercise tolerance and pulmonary function for patients with chronic obstructive pulmonary disease |
| フルテキストURL | 076_018_023.pdf |
| 著者 | 菊池 宏| 保崎 泰弘| 芦田 耕三| 濱田 全紀| 岩垣 尚史| 高田 真吾| 光延 文裕| |
| 抄録 | 我々は現在まで, 慢性閉塞性肺疾患(COPD；chronic obstructive pulmonary disease)患者に対する複合温泉療法(温泉プール運動浴, 鉱泥湿布療法, ヨード吸入) の有効性を報告してきた｡今回, 温熱療法の有効性を明らかにすることを目的として, 温熱療法を 従来の治療に併用し, 運動耐容能および肺機能に対する効果を検討した｡Ａ群７例(68～79歳・男性６例, 女性１例) およびＢ群７例(63～81歳・全例男性), 計14例のCOPD患者を対象とした｡Ａ群については, 薬物・肺理学療法の他に, 温熱療法を週５回で４週間施行した｡ 温熱療法として, 乾式遠赤外線式サウナを用いた60℃, 15分間のサウナ浴(座位) を施行した後, 臥位で30分間全身を毛布で包んで安静保温した｡Ｂ群は, 薬物・肺理学療法のみ４週 続けた｡治療前後で肺機能および６分間歩行試験を施行し比較検討した｡両群とも, 治療開始４週後には６分間歩行での歩行距離, 酸素飽和度(ＳpO2), 修正Borg scaleにて改善を認め, 肺機能においても肺活量(VC；vital capacity), 一秒量(FEV1.0；forced expiratory volume in one second) は上昇した｡両群間の比較では, ６分間歩行試験で上記３項目の改善率はいずれもＡ群はＢ群を凌駕し, Ａ群が優位に運動耐容能の向上を認めた｡Ａ群で修正 Borg scaleの治療４週間後の改善率は有意差(p＜0.01) を認めた｡また肺機能では, ４週間後でVC上昇率はほぼ不変であったがFEV1.0ではＡ群が優位に上昇した｡以上の結果より温熱療法がCOPD治療に有効である可能性が示唆された｡ |
| キーワード | COPD (Chronic obstructive pulmonary disease) 複合温泉療法 (Complex spa therapy) 温熱療法 (Thermal therapy) 肺理学療法 (Lung physiotherapy) 修正Borg scale (6 minute- walk test, Pulmonary function test) |
| 出版物タイトル | 岡大三朝医療センター研究報告 |
| 発行日 | 2008-03-01 |
| 巻 | 76巻 |
| 開始ページ | 18 |
| 終了ページ | 23 |
| ISSN | 1348-1258 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002308391 |