検索結果 24481 件
| JaLCDOI | 10.18926/AMO/55209 |
|---|---|
| フルテキストURL | 71_3_255.pdf |
| 著者 | Kumase, Fumiaki| Morizane, Yuki| Kimura, Shuhei| Toshima, Shinji| Shiraga, Fumio| |
| 抄録 | Parafoveal retinal holes (PRHs) are one of the complications that can occur after internal limiting membrane (ILM) peeling during macular surgery. Here we describe a patient in whom an exceptionally large PRH (1,069-μm dia.) was successfully closed by repeated autologous ILM transplantation. |
| キーワード | autologous internal limiting membrane transplantation parafoveal retinal hole, macular surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 255 |
| 終了ページ | 257 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655946 |
| JaLCDOI | 10.18926/AMO/55208 |
|---|---|
| フルテキストURL | 71_3_249.pdf |
| 著者 | Washio, Kana| Muraoka, Michiko| Kanamitsu, Kiichiro| Oda, Megumi| Shimada, Akira| |
| 抄録 | We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH. |
| キーワード | langerhans cell histiocytosis (LCH) hemophagocytic lymphohistiocytosis (HLH) hematopoietic stem cell transplantation (HSCT) reduced-intensity conditioning (RIC) refractory |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 249 |
| 終了ページ | 254 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655945 |
| JaLCDOI | 10.18926/AMO/55207 |
|---|---|
| フルテキストURL | 71_3_241.pdf |
| 著者 | Iwamuro, Masaya| Tanaka, Shouichi| Moritou, Yuki| Inaba, Tomoki| Higashi, Reiji| Kusumoto, Chiaki| Yunoki, Naoko| Ishikawa, Shin| Okamoto, Yuko| Kawai, Yoshinari| Kitada, Ken-ichi| Takenaka, Ryuta| Toyokawa, Tatsuya| Okada, Hiroyuki| |
| 抄録 | Most gastric bezoars can be treated with endoscopic fragmentation combined with or without cola dissolution, whereas laparotomy or laparoscopic surgery is generally inevitable for small intestinal bezoars because they cause small bowel obstruction. Therefore, early diagnosis and management of gastric bezoars are necessary to prevent bezoar-induced ileus. To investigate the incidence of overlooked gastric bezoars during the initial esophagogastroduodenoscopy, we retrospectively reviewed the cases of 27 patients diagnosed with gastrointestinal bezoars. The bezoars were diagnosed using esophagogastroduodenoscopy (n=25), abdominal ultrasonography (n=1), and barium follow-through examination (n=1). Bezoars were overlooked in 9/25 patients (36.0%) during the initial endoscopy examination because the bezoars were covered with debris in the stomach. Of the 9 patients, 8 had concomitant gastric ulcers, and the other patient had gastric lymphoma. Although a computed tomography (CT) scan was performed before the second-look endoscopy in 8 of the 9 patients, the bezoars were mistaken as food debris on CT findings and were overlooked in these patients. In conclusion, gastric bezoars may not be discovered during the initial esophagogastroduodenoscopy and CT scan. In cases with debris in the stomach, second-look endoscopy is essential to detect bezoars. |
| キーワード | bezoar gastric ulcer foreign bodies phytobezoar |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 241 |
| 終了ページ | 247 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655944 |
| JaLCDOI | 10.18926/AMO/55206 |
|---|---|
| フルテキストURL | 71_3_233.pdf |
| 著者 | Shimoyama, Kyoko| Osako, Tomo| Mitsuhashi, Toshiharu| Akiyama, Futoshi| Iwase, Takuji| |
| 抄録 | Ductal carcinoma in situ (DCIS) of the breast has no potential to metastasize, but over 20% of cases preoperatively diagnosed as DCIS are upstaged on final pathology. The rates of upstaging and the predictors for invasion on final pathology were evaluated. For 240 primary breast cancers, radiological findings on mammography, ultrasonography, and magnetic resonance imaging were investigated along with pathological and clinical information. Univariate and multivariate analyses were performed to identify predictors of potential invasion. Of the 240 breast cancers, 68 (28.3%) showed invasion on final pathology, and 5 (2.5%) had sentinel node metastasis. The multivariate analysis identified five independent predictors: non-mass lesions >2.4 cm on ultrasonography (odds ratio [OR] 2.84, 95% confidence interval [CI] 1.02-7.95, p=0.047), comedo-type histology (OR 6.89, 95% CI 1.89-25.08, p<0.01), solid-type histology (OR 7.97, 95% CI 2.08-30.49, p<0.01), palpable mass (OR 2.63, 95% CI 1.05-6.64, p=0.04), and bloody nipple discharge (OR 4.61, 95% CI 1.20-17.66, p=0.02). These five predictors were associated with invasion on final pathology and may help select candidates for sentinel node biopsy. |
| キーワード | breast cancer DCIS breast needle biopsy imaging examination sentinel node biopsy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 233 |
| 終了ページ | 240 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655943 |
| JaLCDOI | 10.18926/AMO/55205 |
|---|---|
| フルテキストURL | 71_3_227.pdf |
| 著者 | Sasaki, Katsumi| Wada, Koichiro| Araki, Motoo| Kobayashi, Yasuyuki| Sugimoto, Morito| Ebara, Shin| Watanabe, Toyohiko| Nasu, Yasutomo| |
| 抄録 | We elucidate the fate of cases clinically suspected of carcinoma in situ (Cis) of the upper tract with serial ureteroscopy. Of 143 patients who underwent ureteroscopy for suspected upper tract urothelial carcinoma (UTUC) between January 2008 and February 2016, 12 cases with consistently positive urine cytology and poorly detectable upper-tract malignancies by imaging were reviewed. In these 12 patients, 19 ureteroscopy procedures (25 renal units) were performed. Vesical random biopsy was performed before the 1st ureteroscopy to exclude malignancy of the bladder in all 12 cases. Median follow-up was 42 (13-67) months. Positive biopsy results at the 1st ureteroscopy were obtained in 3 (25%) patients and all were diagnosed wth Cis of the upper tract. Two (17%) of 9 patients who were negative or inconclusive at the 1st ureteroscopy were finally diagnosed as UTUC, but plural ureteroscopy procedures were needed for the diagnoses in both. Carcinoma of the bladder appeared in 5 (42%) patients during follow-up, despite the earlier ruling out of vesical malignancy. Four (33%) of those 5 patients never developed upper-tract urothelial carcinoma during follow-up. Caution is required before undertaking radical surgery for cases clinically suspected of Cis of the upper tract. In our experience, only 42% of such patients developed UTUC; another 33% eventually developed carcinoma of the bladder without UTUC. |
| キーワード | carcinoma in situ carcinoma of the bladder upper tract urothelial carcinoma ureteroscopy urine cytology |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 227 |
| 終了ページ | 232 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655942 |
| JaLCDOI | 10.18926/AMO/55204 |
|---|---|
| フルテキストURL | 71_3_219.pdf |
| 著者 | Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira| |
| 抄録 | Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery. |
| キーワード | oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 219 |
| 終了ページ | 226 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655941 |
| JaLCDOI | 10.18926/AMO/55203 |
|---|---|
| フルテキストURL | 71_3_209.pdf |
| 著者 | Xin, Zhao| Tsuda, Toshihide| Doi, Hiroyuki| |
| 抄録 | We evaluated how exposure to airborne volatile organic compounds emitted from a plastic recycling facility affected nearby residents, in a cross-sectional study. Individuals>10 years old were randomly sampled from 50 households at five sites and given questionnaires to complete. We categorized the subjects by distance from the recycling facility and used this as a proxy measure for pollutant exposure. We sought to improve on a preceding study by generating new findings, improving methods for questionnaire distribution and collection, and refining site selection. We calculated the odds of residents living 500 or 900 m away from the facility reporting mucocutaneous and respiratory symptoms using a reference group of residents 2,800 m away. Self-reported nasal congestion (odds ratio=3.0, 95% confidence interval=1.02-8.8), eczema (5.1, 1.1-22.9), and sore throat (3.9, 1.1-14.1) were significantly higher among residents 500 m from the facility. Those 900 m away were also considerably more likely to report experiencing eczema (4.6, 1.4-14.9). Air pollution was found responsible for significantly increased reports of mucocutaneous and respiratory symptoms among nearby residents. Our findings confirm the effects of pollutants emitted from recycling facilities on residents’ health and clarify that study design differences did not affect the results. |
| キーワード | air pollutants volatile organic compounds recycling facility mucocutaneous symptoms respiratory symptoms |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 209 |
| 終了ページ | 217 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655940 |
| JaLCDOI | 10.18926/AMO/55202 |
|---|---|
| フルテキストURL | 71_3_201.pdf |
| 著者 | Matsuda, Miwa| Sasaki, Aiko| Shimizu, Keiko| Kamada, Yasuhiko| Noguchi, Soichi| Hiramatsu, Yuji| Nakatsuka, Mikiya| |
| 抄録 | Vascular dysfunction has been reported in women with recurrent pregnancy loss (RPL). We investigated the severity of vascular dysfunction in non-pregnant women with RPL and its correlation with anti-heat shock protein (HSP) antibodies that are known to induce arteriosclerosis. We measured the serum anti-HSP60 antibodies, anti-HSP70 antibodies, and anti-phospholipid antibodies (APA) in 68 women with RPL and 29 healthy controls. Among the women with RPL, 14 had a diagnosis of antiphospholipid syndrome (APS), and in the remaining 54, the causes for RPL were unexplained. Compared to the controls, the brachial-ankle pulse wave velocity (baPWV), carotid augmentation index (cAI), and uterine artery pulsatility index (PI) were all significantly higher in the women with both APS and unexplained RPL. Compared to the controls, the anti-HSP60 antibody levels were significantly higher in the APA-positive group of women with unexplained RPL, and the anti-HSP70 antibody levels were significantly higher in APS and APA-positive group of women with unexplained RPL. However, the anti-HSP60 and anti-HSP70 antibody levels did not correlate with the values of baPWV or cAI. Our results demonstrated anti-HSP60 and anti-HSP70 antibodies are increased in women with unexplained RPL. Further studies are needed to elucidate the roles of anti-HSP antibodies and their pathophysiology in unexplained RPL. |
| キーワード | recurrent pregnancy loss autoantibody heat shock protein pulse wave velocity arterial stiffness |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 201 |
| 終了ページ | 208 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655939 |
| JaLCDOI | 10.18926/AMO/55201 |
|---|---|
| フルテキストURL | 71_3_191.pdf |
| 著者 | Kobayashi, Katsuhiro| Akiyama, Tomoyuki| Agari, Takashi| Sasaki, Tatsuya| Shibata, Takashi| Hanaoka, Yoshiyuki| Akiyama, Mari| Endoh, Fumika| Oka, Makio| Date, Isao| |
| 抄録 | Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding. |
| キーワード | fast oscillations, epilepsy electroencephalogram time-frequency analysis |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 191 |
| 終了ページ | 200 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655938 |
| フルテキストURL | K0005453_other1.pdf |
|---|---|
| 著者 | Nobumoto, Etsuko| Masuyama, Hisashi| Hiramatsu, Yuji| Sugiyama, Takashi| Kusaka, Hideto| Toyoda, Nagayasu| |
| キーワード | New GDM criteria Perinatal complications Obesity 75-g oral glucose tolerance test |
| 備考 | The final publication is available at Springer| 学位審査副論文| |
| 発行日 | 2015-09 |
| 出版物タイトル | Diabetology International |
| 巻 | 6巻 |
| 号 | 3号 |
| 出版者 | Springer Japan |
| 開始ページ | 226 |
| 終了ページ | 231 |
| ISSN | 21901678 |
| NCID | AA12503387 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| DOI | 10.1007/s13340-014-0193-8 |
| Web of Science KeyUT | 000366631000009 |
| 関連URL | http://doi.org/10.1007/s13340-014-0193-8 http://ousar.lib.okayama-u.ac.jp/55005 |
| フルテキストURL | J_Comp_Neurol_525_7_1586.pdf |
|---|---|
| 著者 | Tamura, Kei| Kobayashi, Yasuhisa| Hirooka, Asuka| Takanami, Keiko| Oti, Takumi| Jogahara, Takamichi| Oda, Sen-ichi| Sakamoto, Tatsuya| Sakamoto, Hirotaka| |
| キーワード | RRID AB_2060157 RRID: AB_2571636 RRID: AB_626757 Suncus murinus (suncus) gastrin-releasing peptide male reproductive function sexual dimorphism spinal cord |
| 備考 | This is the peer reviewed version of the following article: Tamura K. Kobayashi Y. Hirooka A. et al. Identification of the sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that controls male reproductive function in the mouse and Asian house musk shrew (Suncus murinus). J Comp Neurol. 2017;525:1601–1613. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.| 2018年5月公開予定| |
| 発行日 | 2017-05-01 |
| 出版物タイトル | Journal of Comparative Neurology |
| 巻 | 525巻 |
| 号 | 7号 |
| 出版者 | Wistar Institute of Anatomy and Biology |
| 開始ページ | 1586 |
| 終了ページ | 1598 |
| ISSN | 0021-9967 |
| NCID | AA00695917 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 27804131 |
| DOI | 10.1002/cne.24138 |
| Web of Science KeyUT | 000397559700004 |
| 関連URL | https://doi.org/10.1002/cne.24138 |
| フルテキストURL | JoAmChemSoc_2017_139_12_4376.pdf |
|---|---|
| 著者 | Niho, Akiko| Yoshizawa, Susumu| Tsukamoto, Takashi| Kurihara, Marie| Tahara, Shinya| Nakajima, Yu| Mizuno, Misao| Kuramochi, Hikaru| Tahara, Tahei| Mizutani, Yasuhisa| Sudo, Yuki| |
| 備考 | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher.| |
| 発行日 | 2017-03-29 |
| 出版物タイトル | Journal of the American Chemical Society |
| 巻 | 139巻 |
| 号 | 12号 |
| 出版者 | American Chemical Society |
| 開始ページ | 4376 |
| 終了ページ | 4389 |
| ISSN | 00027863 |
| NCID | AA00692602 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 28257611 |
| DOI | 10.1021/jacs.6b12139 |
| Web of Science KeyUT | 000398247100034 |
| 関連URL | isVersionOf https://doi.org/10.1021/jacs.6b12139 |
| フルテキストURL | Acta_Biomater_2017_5.pdf |
|---|---|
| 著者 | Okada, Masahiro| Nakai, Akira| Hara Emilio, Satoshi| Taguchi, Tetsushi| Nakano, Takayoshi| Matsumoto, Takuya| |
| キーワード | Hydroxyapatite Nanoparticle Solid adhesive Wet adhesion |
| 発行日 | 2017-05 |
| 出版物タイトル | Acta Biomaterialia |
| 巻 | 57巻 |
| 出版者 | Elsevier B.V. |
| 開始ページ | 404 |
| 終了ページ | 413 |
| ISSN | 1742-7061 |
| NCID | AA12033647 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 論文のバージョン | author |
| PubMed ID | 28483692 |
| DOI | 10.1016/j.actbio.2017.05.014 |
| Web of Science KeyUT | 000405041900035 |
| 関連URL | https://doi.org/10.1016/j.actbio.2017.05.014 |
| タイトル（別表記） | Identification of Marker Gene of Pars Tuberalis Morphogenesis in Chicken Embryo. The expression of Cytokine-like 1 and Gap junction protein alpha 5 in the pars tuberalis |
|---|---|
| フルテキストURL | poalas_033_031_034.pdf |
| 著者 | 相澤 清香| 檜垣 佑理子| 御輿 真穂| 竹内 栄| 高橋 純夫| |
| 抄録 | Adenohypophysis delivered from oral ectoderm consists of pars distalis (PD), pars intermedia and pars tuberalis (PT). The mechanisms of development of PD has been well studied, and the cell differentiation of PD has been well understood. However, the morphogenesis and the differentiation of PT are still unclear, and the gene expression during the PT development remains largely unknown. In this study, we explored the specifically expressing genes in PT during development and analyzed its spatiotemporal expressions pattern. Microarray analysis on laser-captured PT and PD tissues obtained from chicken embryos on embryonic day 10 (E10.0) showed high expressing genes, Cytokine-like 1 (CYTL1) and Gap junction protein alpha 5 (GJA5) in PT. A detail analysis of spatiotemporal expressions pattern during chick embryo development by in situ hybridization revealed that CYTL1 mRNA was first detected in lateral head ectoderm and ventral head ectoderm in E1.5. The CYTL1 expressions moved into Rathke’s pouch at E2.5, then it was localized in PT primordium and continuously expressed in PT primordium until E12.0. On the other hand, GJA5 mRNA was transiently detected in PT primordium from E6 to E14.0, while the expression was not detected in PD during development. These results suggested that these genes may be involved in the regulation mechanism of PT development and could be a useful marker in the PT development. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 31 |
| 終了ページ | 34 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Structure and function of tegmentum vasculosum in avian cochlea |
|---|---|
| フルテキストURL | poalas_033_026_030.pdf |
| 著者 | 池田 理佐| 乙野 剛史| 池田 直矢| 齋藤 昇| 安藤 元紀| |
| 抄録 | In spite of the importance of endocochlear DC potential (EP) and the K+-rich endolymph for the avian cochlea, the structure and function of the tegmentum vasculosum (TV) has not yet been fully elucidated, compared with those of the stria vascularis in the mammalian cochlea. In this study, we examined structural analysis of the epithelial cells, gene expressions of Na+-K+-ATPase (Atp1A1) and Kir4.1 (Kcnj10), and protein localizations of Na+-K+-ATPase and Kir4.1, in the TV. Tight junctional structures were observed between epithelial dark cells and light cells in the TV. Both Atp1a1 and Kcnj10 genes were detected in the TV. In addition, immunopositive signals for both Na+-K+-ATPase and Kir4.1 were recognized in the TV. These results indicate that Na+-K+-ATPase and Kir4.1 play roles in maintaining the EP and high K+ concentration of the endolymph. Further studies are needed to clarify the physiological functions of the TV. This is the first report which demonstrates that gene and protein expression data contribute to the avian inner ear homeostasis. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 26 |
| 終了ページ | 30 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Taxonomic status of Aco strain derived from spiny mice |
|---|---|
| フルテキストURL | poalas_033_022_025.pdf |
| 著者 | 持田 瞳| 目加田 和之| |
| 抄録 | Spiny mice are useful in regenerative research and as a model for precocial animals. In the present study, we investigated the taxonomic status of the Aco strain, which is derived from spiny mice of an unidentified species. Although this Aco strain has been tentatively considered A. cahirinus species, it was distinguished from this species based on conventional and G-banding chromosomal patterns of this strain. Subsequently, we determined the nucleotide sequence of the mitochondorial gene cytochrome b (Cyb) and constructed a molecular phylogenetic tree. We found that the Aco strain belongs to the same clade as A. dimidiatus. Based on this molecular analysis, we concluded that the Aco strain of spiny mice should be considered A. dimidiatus. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 22 |
| 終了ページ | 25 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Inhibitory effects of caffeine on allergic rhinitis symptoms in mice |
|---|---|
| フルテキストURL | poalas_033_018_021.pdf |
| 著者 | 辻本 まどか| 佐伯 綾希子| 鈴木 真奈美| 白神 俊幸| 杉本 幸雄| 林 泰資| |
| 抄録 | We examined the effects of caffeine treatment on ovalbumin- and histamine-induced rhinitis mouse models and on corticosterone and catecholamine levels in mouse plasma. Treatment with caffeine decreased sneezing and nasal rubbing in both models, but direct nasal administration had no effect. Plasma levels of corticosterone and catecholamine, which have known anti-allergy effects, were increased by caffeine treatment. The increases in corticosterone and catecholamine may be associated with the suppression of rhinitis symptoms. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 18 |
| 終了ページ | 21 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | An Efficient Algorithm to Determine Equivalence of Pipelined Dependency Graphs for Their Simplification |
|---|---|
| フルテキストURL | j100-d_6_616.pdf |
| 著者 | 籠谷 裕人| 杉山 裕二| 岡本 卓爾| |
| キーワード | 非同期式制御回路 パイプライン 簡単化 因果関係 |
| 備考 | 本研究は，JSPS 科研費 JP24500065，JP16H01723 の助成を受けたものである．| |
| 発行日 | 2017-06-01 |
| 出版物タイトル | 電子情報通信学会論文誌 D |
| 巻 | J100-D巻 |
| 号 | 6号 |
| 出版者 | 電子情報通信学会 |
| 開始ページ | 616 |
| 終了ページ | 626 |
| ISSN | 18810225 |
| NCID | AA12712944 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 日本語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | Copyright (c) by IEICE |
| 論文のバージョン | publisher |
| DOI | 10.14923/transinfj.2016JDP7108 |
| オフィシャル URL | https://search.ieice.org/| |
| フルテキストURL | K0005518_abstract_review.pdf K0005518_summary.pdf K0005518_fulltext.pdf |
|---|---|
| 著者 | 恵谷 玲央| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5518号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（看護学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005509 abstract_review.pdf K0005509_summary.pdf K0005509_fulltext.pdf |
|---|---|
| 著者 | 川端 勇也| |
| 発行日 | 2017-03-24 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5509号 |
| 学位授与年月日 | 2017-03-24 |
| 学位・専攻分野 | 博士（歯学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |