検索結果 14073 件
| フルテキストURL | fulltext20221004-1.pdf Figure_1_20221004-1.jpg Figure_2A_20221004-1.jpg Figure_2B_20221004-1.jpg Figure_2C_20221004-1.jpg Figure_2D_20221004-1.jpg Figure_3_20221004-1.jpg Figure_4_20221004-1.jpg |
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| 著者 | Matsumoto, Kazuyuki| Kato, Hironari| Fujii, Masakuni| Ueki, Toru| Saragai, Yosuke| Tsugeno, Hirofumi| Mannami, Tomohiko| Okada, Hiroyuki| |
| キーワード | benign biliary stricture fully-covered self-expandable metal stent intraductal placement refractory biliary stricture |
| 備考 | This is the peer reviewed version of the following article: [Matsumoto, K, Kato, H, Fujii, M, Ueki, T, Saragai, Y, Tsugeno, H, Efficacy of intraductal placement of nonflared fully-covered metal stent for refractory perihilar benign biliary strictures: A multicenter prospective study with long-term observation. J Hepatobiliary Pancreat Sci. 2022; 29: 1300– 1307. https://doi.org/10.1002/jhbp.1188], which has been published in final form at [https://doi.org/10.1002/jhbp.1188]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext is available in June 2023.| |
| 発行日 | 2022-06-03 |
| 出版物タイトル | Journal of Hepato-Biliary-Pancreatic Sciences |
| 巻 | 29巻 |
| 号 | 12号 |
| 出版者 | Wiley |
| 開始ページ | 1300 |
| 終了ページ | 1307 |
| ISSN | 1868-6974 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Japanese Society of Hepato-Biliary-Pancreatic Surgery. |
| 論文のバージョン | author |
| PubMed ID | 35657019 |
| DOI | 10.1002/jhbp.1188 |
| Web of Science KeyUT | 000814050800001 |
| 関連URL | isVersionOf https://doi.org/10.1002/jhbp.1188 |
| フルテキストURL | fulltext20220912-1.pdf |
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| 著者 | Asano, Takao| Shibata, Akihisa| Yokoo, Masanori| |
| キーワード | CES production functionchaos complex dynamics middle-income traps nonlinearities technology choice |
| 備考 | The final publication is available at www.degruyter.com.| This fulltext is available in Sep. 2023.| |
| 発行日 | 2022-09-06 |
| 出版物タイトル | Studies in Nonlinear Dynamics & Econometrics |
| 出版者 | Walter de Gruyter GmbH |
| ISSN | 1081-1826 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Walter de Gruyter GmbH, Berlin/Boston |
| 論文のバージョン | publisher |
| DOI | 10.1515/snde-2021-0100 |
| Web of Science KeyUT | 000850297500001 |
| 関連URL | isVersionOf https://doi.org/10.1515/snde-2021-0100 |
| フルテキストURL | fulltext20220922-2.pdf Table1_20220922-2.pdf Table2_20220922-2.pdf figure20220922-2.pdf |
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| 著者 | Sato, Ryosuke| Matsumoto, Kazuyuki| Matsumi, Akihiro| Morimoto, Kosaku| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Tsutsumi, Koichiro| Horiguchi, Shigeru| Kato, Hironari| |
| キーワード | EUS-guided pancreatic duct drainage Pancreatic duct perforation ERCP-related perforation |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12328-022-01699-1 This fulltext is available in Sep. 2023.| |
| 発行日 | 2022-09-12 |
| 出版物タイトル | Clinical Journal of Gastroenterology |
| 巻 | 15巻 |
| 号 | 6号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 1179 |
| 終了ページ | 1184 |
| ISSN | 1865-7257 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Japanese Society of Gastroenterology 2022 |
| 論文のバージョン | author |
| PubMed ID | 36094734 |
| DOI | 10.1007/s12328-022-01699-1 |
| Web of Science KeyUT | 000852906700001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s12328-022-01699-1 |
| フルテキストURL | fulltext20220922-1.pdf figure20220922-1.pdf |
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| 著者 | Okada, Satoshi| Lei, Gui J.| Yamaji, Naoki| Huang, Sheng| Ma, Jian F.| Mochida, Keiichi| Hirayama, Takashi| |
| キーワード | oestrogen induction system fep1-1 iron-deficiency response transcriptome |
| 備考 | This is the peer reviewed version of the following article: [Okada, S., Lei, G.J., Yamaji, N., Huang, S., Ma, J.F., Mochida, K., et al. (2022) FE UPTAKE-INDUCING PEPTIDE1 maintains Fe translocation by controlling Fe deficiency response genes in the vascular tissue of Arabidopsis. Plant, Cell & Environment, 45, 3322–3337. https://doi.org/10.1111/pce.14424], which has been published in final form at [https://doi.org/10.1111/pce.14424]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. This fulltext is available in Sep. 2023.| |
| 発行日 | 2022-09-07 |
| 出版物タイトル | Plant, Cell and Environment |
| 巻 | 45巻 |
| 号 | 11号 |
| 出版者 | Wiley |
| 開始ページ | 3322 |
| 終了ページ | 3337 |
| ISSN | 0140-7791 |
| NCID | AA0036238X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 John Wiley & Sons Ltd. |
| 論文のバージョン | author |
| PubMed ID | 35993196 |
| DOI | 10.1111/pce.14424 |
| Web of Science KeyUT | 000850502800001 |
| 関連URL | isVersionOf https://doi.org/10.1111/pce.14424 |
| フルテキストURL | fulltext20220921-2.pdf |
|---|---|
| 著者 | Morimoto, Eisaku| Inagaki, Kenichi| Komatsubara, Motoshi| Terasaka, Tomohiro| Itoh, Yoshihiko| Fujisawa, Satoshi| Sasaki, Erika| Nishiyama, Yuki| Hara, Takayuki| Wada, Jun| |
| キーワード | Wnt-β-catenin signaling sclerostin catecholamine PPGL PC12 |
| 発行日 | 2022-8-5 |
| 出版物タイトル | Journal of the Endocrine Society |
| 巻 | 6巻 |
| 号 | 10号 |
| 出版者 | The Endocrine Society |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 2472-1972 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 36042979 |
| DOI | 10.1210/jendso/bvac121 |
| Web of Science KeyUT | 000845523100003 |
| 関連URL | isVersionOf https://doi.org/10.1210/jendso/bvac121 |
| フルテキストURL | fulltext20220921-1.pdf |
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| 著者 | Munene, Kwenga Ismael| Funabiki, Nobuo| Rahman, Md. Mahbubur| Briantoro, Hendy| Roy, Sujan Chandra| Kuribayashi, Minoru| |
| キーワード | Internet of Things WLAN partially overlapping channel access point transmission power channel bonding non-channel bonding throughput drop |
| 備考 | © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.iot.2022.100583] . | |
| 発行日 | 2022-11 |
| 出版物タイトル | Internet of Things |
| 巻 | 20巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 100583 |
| ISSN | 2542-6605 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Elsevier B.V. |
| 論文のバージョン | author |
| DOI | 10.1016/j.iot.2022.100583 |
| Web of Science KeyUT | 000841402900001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.iot.2022.100583 |
| JaLCDOI | 10.18926/bgeou/63921 |
|---|---|
| フルテキストURL | bgeou_180_027_037.pdf |
| 著者 | Yoshitoshi, Munehisa| Tsushima, Yasuko| Murakami, Rie| Takahashi, Kiriko| |
| 抄録 | The objective of this study was to examine mainstream school teachers’ anxiety and selfefficacy to teaching students with chronic illness. A survey was completed by 59 elementary and 44 junior high school teachers in Japan. Results indicated that the majority of teacher respondents perceived themselves as inadequate to teach students with chronic illness due to lack of practical knowledge and experience. A high proportion of respondents indicated that they had no academic training (62.1%) and no teaching experience (72.8%) for supporting students with chronic illness. On the other hand, there is a positive relationship between selfefficacy, anxiety level and academic training or teaching experience for supporting students with chronic illness. That is, teachers with practical experience teaching students with chronic illness in the classroom and teachers with more academic training in inclusive approaches demonstrated higher efficacy and lower anxiety than teachers without these experiences or with less training in inclusive teaching approaches. All teachers must be equipped with the extensive knowledge of how best to assist students with chronic illness. Additional efforts are needed to adequately support students with chronic illness in the regular education classroom. |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2022-08-26 |
| 巻 | 180巻 |
| 開始ページ | 27 |
| 終了ページ | 37 |
| ISSN | 1883-2423 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/AMO/63906 |
|---|---|
| フルテキストURL | 76_4_465.pdf |
| 著者 | Bekku, Kensuke| Tsugawa, Takuji| Tsuboi, Kazuma| Noda, Gaku| Inoue, Yousuke| Murao, Wataru| Ebara, Shin| |
| 抄録 | We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint. Survival was compared using the log-rank test. A total of 108 patients were retrospectively analyzed. The numbers of patients in the favorable-, intermediate-, and poor-risk groups were 32 (30%), 66 (61%), and 10 (9%), repestively. The median OS values in the entire cohort was 36 months (95% confidence interval [CI] 29-53). The median OS in the favorable, intermediate, and poor risk groups were 94 months (95% CI: 43-Not reached), 30 months (95% CI: 20-38), and 8 months (95% CI: 0-Not reached), respectively (p<0.05). Prior nephrectomy, clear cell histology, clinical T stage ≤2, no metastasis at the time of diagnosis, nivolumab beyond first-line therapy, and objective response to VEGFR-TKIs were factors significantly prolonging OS on univariate analysis. VEGFR-TKI monotherapy as first-line therapy was an effective treatment option for patients with metastatic clear cell RCC with favorable risk. |
| キーワード | metastatic renal cell carcinoma molecular-targeted therapy immuno-checkpoint inhibitor real-world setting |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 465 |
| 終了ページ | 472 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123162 |
| JaLCDOI | 10.18926/AMO/63905 |
|---|---|
| フルテキストURL | 76_4_457.pdf |
| 著者 | Sun, Weiying| Hasebe, Satoshi| |
| 抄録 | To clarify the preventive effects of 0.01% atropine eye drops against myopia progression and axial elongation in children, a meta-analysis was carried out based on data obtained from PubMed and Web of Science as of August 1, 2021. Randomized controlled trials (RCTs) that enrolled myopic children who had received atropine for at least one year were included in this study, Key search terms included myopia, children, and 0.01% or low-dose atropine. Heterogeneity was quantified by I2 statistics, and meta-analyses were performed using the fixed-effect model. Five RCTs involving 809 unique children were analyzed. One trial was excluded because of a poor Jadad score and markedly rapid myopia progression in controls. The mean effect sizes for 12 months in myopia progression and axial elongation synthesized from the remaining 4 RCTs were 0.20 (95% CI: 0.13 to 0.27) D and −0.08 (−0.11 to −0.04) mm, respectively (p<0.0001). The corresponding inhibition ratios were 28% and 19%. I2 statistics were 6% or less. Sensitivity analysis and funnel plots demonstrated the robustness of the estimation. The 0.01% atropine-induced inhibition ratio for myopia progression in Asian children was roughly half of that originally reported and did not reach the minimum requirement for clinical treatment. |
| キーワード | myopia 0.01% atropine low-dose atropine axial length myopia progression |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 457 |
| 終了ページ | 463 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123161 |
| Web of Science KeyUT | 000882167300011 |
| JaLCDOI | 10.18926/AMO/63904 |
|---|---|
| フルテキストURL | 76_4_447.pdf |
| 著者 | Umemura, Hiroshi| Fukuda, Yoshiaki| Miyashita, Tetsuo| Nakayama, Tomohiro| |
| 抄録 | The erythrocyte sedimentation rate (ESR) is a widely used marker of inflammation, but the detailed mechanisms underlying the ESR remain unclear. We retrospectively collected laboratory data from our hospital’s laboratory information system, and performed multiple linear regression analysis and correlation analysis to determine relationships between the ESR and other laboratory test parameters. The alpha-2, beta-2, and gamma fractions from serum protein electrophoresis, serum immunoglobulin (Ig) G, IgA, IgM, and complement C3 levels, plasma fibrinogen levels, and platelet count showed positive effects on the ESR; however, the serum albumin level showed negative effects. Since erythrocytes are negatively charged, an increase in positively charged proteins and a decrease in negatively charged albumin were suggested to increase the ESR. Notably, C-reactive protein (CRP) showed the third-strongest correlation with the ESR despite having no significant effect on the ESR. We also reviewed cases with discordant ESR and CRP levels to compare the disease profiles of high ESR/low CRP patients and low ESR/high CRP patients. The patients with high ESR/low CRP had a completely different disease profile from those with low ESR/high CRP. Since the ESR and CRP have different roles, they should be used as markers in a context-dependent manner. |
| キーワード | complement erythrocyte sedimentation rate fibrinogen immunoglobulin serum protein electrophoresis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 447 |
| 終了ページ | 455 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123160 |
| JaLCDOI | 10.18926/AMO/63903 |
|---|---|
| フルテキストURL | 76_4_439.pdf |
| 著者 | Miyaji, Chikara| Takao, Soshi| Noguchi, Masayuki| Okazaki, Tsubasa| Sato, Shunsuke| Yorifuji, Takashi| |
| 抄録 | This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged≥18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex. |
| キーワード | social capital post-traumatic stress disorder disaster flooding |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 439 |
| 終了ページ | 446 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123159 |
| Web of Science KeyUT | 000882167300010 |
| JaLCDOI | 10.18926/AMO/63901 |
|---|---|
| フルテキストURL | 76_4_423.pdf |
| 著者 | Takahashi, Satoshi| Kushibe, Takuya| Akezaki, Yoshiteru| Horiike, Norio| |
| 抄録 | We compared the effects of an exercise intervention with that of exercise combined with nutrition therapy in patients with possible malnutrition and sarcopenia admitted to a recovery rehabilitation ward, and we examined the differences in the patients’ physical function and activities of daily living (ADLs). There were 16 patients in the Exercise group with exercise therapy and ADL exercises, and 14 patients in the Combined intervention group with exercise therapy, ADL exercises, and nutrition therapy. The survey items were body weight, body mass index, grip strength, lower-leg circumference, gait speed, and ADLs, each of which was measured at the baseline and at 2 weeks, 4 weeks, and at discharge. Significant improvements in grip strength were observed in the Combined intervention group as follows: at 4 weeks>at 2 weeks (p<0.05), and at discharge>baseline and 2 weeks (p<0.05). There were no significant changes in the Exercise group, and an interaction was recognized in both groups. Comprehensive rehabilitation including nutrition therapy is necessary for patients with possible malnutrition and/or sarcopenia, as our results indicate that nutrition therapy in addition to exercise therapy has the effect of promoting improvements of physical function in such patients. |
| キーワード | sarcopenia rehabilitation exercise therapy nutrition therapy grip strength |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 423 |
| 終了ページ | 428 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123157 |
| Web of Science KeyUT | 000882167300008 |
| JaLCDOI | 10.18926/AMO/63896 |
|---|---|
| フルテキストURL | 76_4_415.pdf |
| 著者 | Kang, Haijun| Huang, Dongmei| Kang, Gangjin| Yang, Xu| Li, Heng| Liu, Siyuan| Gou, Wenjun| Liu, Linglin| Qiu, Yuyan| |
| 抄録 | Posterior capsule opacification (PCO) is a post-surgery complication of cataract surgery, and lens epithelial cells (LECs) are involved in its development. A suppressive effect on LECs is exerted by the non specific chloride channel inhibitor 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) exerts. Herein, the growth and migration inhibitory effects of NPPB on LECs were assessed, and the mechanism underlying the effects were investigated by focusing on Ca2+/CaMKII signaling. LECs were treated with different concentrations of NPPB, and the changes in cell viability, cell-cycle distribution, anchorage-dependent growth, migration, Ca2+ level, and CaMKII expression were evaluated. NPPB inhibited LECs’ proliferation and induced G1 cell-cycle arrest in the cells. Regarding LECs’ mobility, NPPB suppressed the cells’ anchorage-dependent growth ability and inhibited their migration. Changes in cell phenotypes were associated with an increased intracellular Ca2+ level and down-regulation of CaMKII. Together these results confirmed the inhibitory effect of NPPB on the proliferation and migration of LECs, and the effect was shown to be associated with the induced level of Ca2+ and the inhibition of CaMKII signaling transduction. |
| キーワード | 5-nitro-2-(3-phenylpropylamino) benzoic acid CaMKII lens epithelial cell migration proliferation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 415 |
| 終了ページ | 421 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123156 |
| Web of Science KeyUT | 000882167300007 |
| JaLCDOI | 10.18926/AMO/63895 |
|---|---|
| フルテキストURL | 76_4_409.pdf |
| 著者 | Higashikawa, Toshihiro| Shigemoto, Kenji| Goshima, Kenichi| Iwai, Shintarou| Moriyama, Manabu| Usuda, Daisuke| Hangyou, Masahiro| Inujima, Hiromi| Nozaki, Kakeru| Yamaguchi, Miyako| Usuda, Kimiko| Nakahashi, Takeshi| Matsumoto, Tadami| Takashima, Shigeki| Kanda, Tsugiyasu| Horii, Takeshi| Okuro, Masashi| Sawaguchi, Takeshi| |
| 抄録 | We assessed risk factors for postoperative urinary retention (UR) in elderly males with femoral bone fractures: 169 Japanese males (mean age 81.95 ± 1.19 years) who had undergone hip surgery at a municipal hospital (Toyama, Japan). A multiple logistic regression analysis was used to test possible risk factors for UR: age, body mass index, serum albumin, cognitive impairment, activities of daily living (ADL), and history of diabetes mellitus (DM). UR occurred in 24 (14.2%) of the 169 patients. A multivariate logistic regression analysis with age adjustment showed that ADL (odds ratio [OR] 3.88; 95% confidence interval [CI]: 1.2-12.5, p=0.023) was significantly associated with the development of UR, and a history of DM showed marginal significance for UR occurrence (OR 0.36, 95%CI: 0.11-10, p=0.064). These results suggests that ADL is a risk factor for UR development in elderly males who have undergone surgery for femoral neck or trochanter fractures. |
| キーワード | elderly femoral bone fracture albumin urinary retention activities of daily living |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 409 |
| 終了ページ | 414 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123155 |
| Web of Science KeyUT | 000882167300006 |
| JaLCDOI | 10.18926/AMO/63894 |
|---|---|
| フルテキストURL | 76_4_399.pdf |
| 著者 | Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| 抄録 | According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67. |
| キーワード | breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 399 |
| 終了ページ | 408 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123154 |
| Web of Science KeyUT | 000882167300005 |
| JaLCDOI | 10.18926/AMO/63889 |
|---|---|
| フルテキストURL | 76_4_373.pdf |
| 著者 | Imafuku, Fuminori| Miyazaki, Ikuko| Sun, Jin| Kamimai, Sunao| Shimizu, Takashi| Toyota, Toshiaki| Okamoto, Yusei| Isooka, Nami| Kikuoka, Ryo| Kitamura, Yoshihisa| Asanuma, Masato| |
| 抄録 | Parkinson’s disease (PD) is a progressive neurodegenerative disease of both the central and peripheral / enteric nervous systems. Oxidative stress and neuroinflammation are associated with the pathogenesis of PD, suggesting that anti-oxidative and anti-inflammatory compounds could be neuroprotective agents for PD. Eucommia ulmoides (EU) is a traditional herbal medicine which exerts neuroprotective effects by anti-inflammatory and anti-oxidative properties. Our previous study showed that treatment with chlorogenic acid, a component of EU, protected against neurodegeneration in the central and enteric nervous systems in a PD model. In this study, we examined the effects of EU extract (EUE) administration on dopaminergic neurodegeneration, glial response and α-synuclein expression in the substantia nigra pars compacta (SNpc), and intestinal enteric neurodegeneration in low-dose rotenone-induced PD model mice. Daily oral administration of EUE ameliorated dopaminergic neurodegeneration and α-synuclein accumulation in the SNpc. EUE treatment inhibited rotenone- induced decreases in the number of total astrocytes and in those expressing the antioxidant molecule metallothionein. EUE also prevented rotenone-induced microglial activation. Furthermore, EUE treatment exerted protective effects against intestinal neuronal loss in the PD model. These results suggest that EU exerts neuroprotective effects in the central and enteric nervous systems of rotenone-induced parkinsonism mice, in part by glial modification. |
| キーワード | Eucommia ulmoides dopamine neuron enteric neuron glia Parkinson’s disease |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 373 |
| 終了ページ | 383 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123151 |
| Web of Science KeyUT | 000882167300003 |
| JaLCDOI | 10.18926/AMO/63887 |
|---|---|
| フルテキストURL | 76_4_359.pdf |
| 著者 | Hiramatsu-Asano, Sumie| Wada, Jun| |
| 抄録 | Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE. |
| キーワード | systemic lupus erythematosus miRNA miRNA targeting therapy |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 359 |
| 終了ページ | 371 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123150 |
| Web of Science KeyUT | 000882167300002 |
| フルテキストURL | fulltext20220908-1.pdf |
|---|---|
| 著者 | Matsuo, Toshihiko| Chaomulige| Miyaji, Mary| Hosoya, Osamu| Saito, Akira| Nakazono, Kazuyuki| |
| キーワード | whole genome sequencing idiopathic superior oblique muscle palsy strabismus esotropia exotropia linkage analysis single nucleotide variations and short insertions/deletions SNVs/InDels SSTR5-AS1 bioinformatics muscle hypoplasia (aplasia) |
| 発行日 | 2022-08-03 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 23巻 |
| 号 | 15号 |
| 出版者 | MDPI AG |
| 開始ページ | 8626 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
| 論文のバージョン | publisher |
| PubMed ID | 35955756 |
| DOI | 10.3390/ijms23158626 |
| Web of Science KeyUT | 000838931000001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms23158626 |
| フルテキストURL | fulltext20220830-4.pdf CMT2Z Figure NCN revise.tif CMT2Z Table NCN revise.tif |
|---|---|
| 著者 | Nomura, Emi| Tadokoro, Koh| Sasaki, Ryo| Nakata, Yumi| Nakano, Yumiko| Yunoki, Taijun| Takemoto, Mami| Morihara, Ryuta| Ando, Masahiro| Takashima, Hiroshi| Yamashita, Toru| |
| キーワード | Charcot-Marie-Tooth disease type 2Z MORC2 retinitis pigmentosa |
| 備考 | This is the peer reviewed version of the following article: [Nomura, E, Tadokoro, K, Sasaki, R, et al. Japanese case of Charcot–Marie–Tooth disease type 2Z with severe retinitis pigmentosa. Neurol Clin Neurosci. 2022; 10: 266-268. doi: 10.1111/ncn3.12660], which has been published in final form at [https://doi.org/10.1111/ncn3.12660]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| 発行日 | 2022-08-15 |
| 出版物タイトル | Neurology and Clinical Neuroscience |
| 巻 | 10巻 |
| 号 | 5号 |
| 出版者 | Wiley |
| 開始ページ | 266 |
| 終了ページ | 268 |
| ISSN | 2049-4173 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd. |
| 論文のバージョン | author |
| DOI | 10.1111/ncn3.12660 |
| Web of Science KeyUT | 000843400700001 |
| 関連URL | isVersionOf https://doi.org/10.1111/ncn3.12660 |
| フルテキストURL | fulltext20220830-3.pdf |
|---|---|
| 著者 | Amioka, Naofumi| Takaishi, Atsushi| Nakamura, Kazufumi| Endo, Toyohiro| Iida, Toshihiro| Yamaji, Tatsuya| Mori, Hisatoshi| Kishinoue, Takao| Yasuhara, Kentaro| Matsuo, Naoaki| Tanimoto, Masafumi| Nakano, Yukari| Onishi, Nobuhiko| Ueeda, Masayuki| Ito, Hiroshi| |
| キーワード | Clinical pathway Acute decompensated heart failure Tolvaptan Cardiac rehabilitation Prognosis |
| 備考 | © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jjcc.2022.03.014] . | |
| 発行日 | 2022-09 |
| 出版物タイトル | Journal of Cardiology |
| 巻 | 80巻 |
| 号 | 3号 |
| 出版者 | Elsevier BV |
| 開始ページ | 232 |
| 終了ページ | 239 |
| ISSN | 0914-5087 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Elsevier B.V. |
| 論文のバージョン | author |
| PubMed ID | 35428556 |
| DOI | 10.1016/j.jjcc.2022.03.014 |
| Web of Science KeyUT | 000838175500008 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jjcc.2022.03.014 |
