検索結果 14070 件
| フルテキストURL | fulltext20230112-1.pdf |
|---|---|
| 著者 | Yoshitoshi, Munehisa| Horiguchi, Goro| Takahashi, Kiriko| |
| キーワード | Human rights inclusive education court litigation reasonable accommodation symbiotic society |
| 備考 | This is an Accepted Manuscript of an article published by Taylor & Francis in [Disability & Society] on [2022-12-16], available online: http://www.tandfonline.com/10.1080/09687599.2022.2157705| This full-text file will be available in June 2024.| |
| 発行日 | 2022-12-16 |
| 出版物タイトル | Disability & Society |
| 巻 | 39巻 |
| 号 | 6号 |
| 出版者 | Informa UK Limited |
| 開始ページ | 1423 |
| 終了ページ | 1442 |
| ISSN | 0968-7599 |
| NCID | AA10993999 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1080/09687599.2022.2157705 |
| Web of Science KeyUT | 000898598900001 |
| 関連URL | isVersionOf https://doi.org/10.1080/09687599.2022.2157705 |
| フルテキストURL | fulltext20230110-1.pdf Table1_20230110-1.pdf Table2_20230110-1.pdf Table3_20230110-1.pdf Table4_20230110-1.pdf Figure 1A.jpg Figure 1B.jpg Figure 1C.jpg Figure 1D.jpg Figure 1E.jpg Figure 1F.jpg |
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| 著者 | Matsumoto, Kazuyuki| Kato, Hironari| |
| キーワード | ablation techniques endoscopic ultrasonography ethanol pancreatic neoplasms radiofrequency ablation |
| 備考 | This is the peer reviewed version of the following article: [Matsumoto, K. and Kato, H. (2023), Endoscopic ablation therapy for the pancreatic neoplasms. Digestive Endoscopy. https://doi.org/10.1111/den.14468], which has been published in final form at [https://doi.org/10.1111/den.14468]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This full-text file will be available in Dec. 2023.| |
| 発行日 | 2022-12-13 |
| 出版物タイトル | Digestive Endoscopy |
| 巻 | 35巻 |
| 号 | 4号 |
| 出版者 | Wiley |
| 開始ページ | 430 |
| 終了ページ | 442 |
| ISSN | 0915-5635 |
| NCID | AA10907137 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Japan Gastroenterological Endoscopy Society. |
| 論文のバージョン | author |
| PubMed ID | 36366955 |
| DOI | 10.1111/den.14468 |
| Web of Science KeyUT | 000897965200001 |
| 関連URL | isVersionOf https://doi.org/10.1111/den.14468 |
| フルテキストURL | fulltext20221227-2.pdf |
|---|---|
| 著者 | Takata, Jun| Miyake, Naoko| Saiki, Yusuke| Tada, Misako| Sasaki, Kensuke| Kubo, Toshio| Kiura, Katsuyuki| Arimoto-Kobayashi, Sakae| |
| キーワード | Akt signal transduction Lung tumorigenesis Anti-mutagenesis DNA methylation Tobacco-specific nitrosamine Isoquercetin |
| 発行日 | 2022-12-09 |
| 出版物タイトル | Genes and Environment |
| 巻 | 44巻 |
| 号 | 1号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 26 |
| ISSN | 1880-7062 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 36494703 |
| DOI | 10.1186/s41021-022-00255-0 |
| Web of Science KeyUT | 000896571200001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s41021-022-00255-0 |
| フルテキストURL | fulltext20221223-1.pdf |
|---|---|
| 著者 | Kawashima, Shusuke| Togashi, Yosuke| |
| キーワード | immune checkpoint inhibitors tumor microenvironment antitumor immunity primary resistance acquired resistance |
| 備考 | This is the peer reviewed version of the following article: [Kawashima, S, Togashi, Y. Resistance to immune checkpoint inhibitors and the tumor microenvironment. Exp Dermatol. 2022; 00: 1- 10. doi:10.1111/exd.14716], which has been published in final form at [https://doi.org/10.1111/exd.14716]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This full-text will be available in Nov. 2023.| |
| 発行日 | 2022-12-08 |
| 出版物タイトル | Experimental Dermatology |
| 巻 | 32巻 |
| 号 | 3号 |
| 出版者 | Wiley |
| 開始ページ | 240 |
| 終了ページ | 249 |
| ISSN | 0906-6705 |
| NCID | AA10958794 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| 論文のバージョン | author |
| PubMed ID | 36437644 |
| DOI | 10.1111/exd.14716 |
| Web of Science KeyUT | 000894179800001 |
| 関連URL | isVersionOf https://doi.org/10.1111/exd.14716 |
| タイトル（別表記） | Cases of patient discharge from the Kyushu Leprosarium in the Early Showa period |
|---|---|
| JaLCDOI | 10.18926/64200 |
| フルテキストURL | jdc_002_032.pdf |
| 著者 | 松岡 弘之| |
| 抄録 | Although it has been said that modern Japanese santoria for Hansen's disease quarantined patients for their entire lives, there were a small number of cases of "arrested discharges" (a "provisional discharge" when progress of the disease was halted) in the 1920s. To examine the reasons why this practice did not spread in Japan, this paper considers the background that led to the admission of patients who were later discharged from the Kyushu Sanatorium (九州療養所) to analyze two types of discharges: "Arrested discharges" and "discharge by relatives." To do so, this paper draws on the "Patient Identification Records"(身分帳) created by the Fifth Ward United Kyushu Sanatorium (now National Sanatorium Kikuchi Keifuen) to manage patients' admission and discharge from the sanatorium. This analysis clarified specific procedures of "arrested discharges" from the facility, which had previously been completely unknown, and it further revealed that regardless if the patients were discharged as an arrested case or by relatives, emphasis was placed upon their prospects for life after discharge, such as the availability of people to support their care and a minimum standard of living |
| キーワード | Hansen's disease sanatoria quarantine modern Japan |
| Amo Type | 研究ノート (Research note) |
| 出版物タイトル | 文明動態学 |
| 発行日 | 2023-03-25 |
| 巻 | 2巻 |
| 出版者 | 岡山大学文明動態学研究所 |
| 開始ページ | 32 |
| 終了ページ | 43 |
| ISSN | 2436-8326 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 日本語 |
| 著作権者 | ©2023 by RIDC |
| 論文のバージョン | publisher |
| フルテキストURL | fulltext20221215-1.pdf figures20221215-1.pdf Supple_Figures20221215-1.pdf Supple_Table20221215-1.pdf |
|---|---|
| 著者 | Kajiwara, Yoshinori| Tazawa, Hiroshi| Yamada, Motohiko| Kanaya, Nobuhiko| Fushimi, Takuro| Kikuchi, Satoru| Kuroda, Shinji| Ohara, Toshiaki| Noma, Kazuhiro| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| キーワード | Pancreatic cancer Chemoresistance MDSC GM-CSF Oncolytic virus |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00262-022-03334-x| This full-text of the article will be available in Nov. 2023.| |
| 発行日 | 2022-11-27 |
| 出版物タイトル | Cancer Immunology, Immunotherapy |
| 巻 | 72巻 |
| 号 | 5号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 1285 |
| 終了ページ | 1300 |
| ISSN | 0340-7004 |
| NCID | AA00598499 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 |
| 論文のバージョン | author |
| PubMed ID | 36436021 |
| DOI | 10.1007/s00262-022-03334-x |
| Web of Science KeyUT | 000889040300003 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00262-022-03334-x |
| フルテキストURL | fulltext20221130-2.pdf |
|---|---|
| 著者 | Matsuo, Toshihiko| Noda, Hiroshi| |
| 発行日 | 2022-11-27 |
| 出版物タイトル | Clinical Case Reports |
| 巻 | 10巻 |
| 号 | 11号 |
| 出版者 | Wiley |
| 開始ページ | e06657 |
| ISSN | 2050-0904 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Authors. |
| 論文のバージョン | publisher |
| DOI | 10.1002/ccr3.6657 |
| フルテキストURL | fulltext20221124-1.pdf DBA_Figure1_20220614_400.jpg |
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| 著者 | Tamefusa, Kosuke| Muraoka, Michiko| Washio, Kana| Wakamatsu, Manabu| Shimada, Akira| |
| キーワード | Diamond-Blackfan anemia neutropenia next-generation sequencing RPL35A variant |
| 備考 | This is the peer reviewed version of the following article: [Tamefusa, K., Muraoka, M., Washio, K., Wakamatsu, M. and Shimada, A. (2022), Late-onset familial Diamond–Blackfan anemia with neutropenia caused by RPL35A variant. Pediatrics International, 64: e15275.], which has been published in final form at [https://doi.org/10.1111/ped.15275]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
This is the Accepted Manuscript. This full-text does not reflect post-acceptance improvements, or any corrections. この論文は著者最終稿版です。受理後の校正・修正を反映していないため、表現が最終版と異なる箇所があります。| This full-text will be available in Oct. 2023.| |
| 発行日 | 2022-10-18 |
| 出版物タイトル | Pediatrics International |
| 巻 | 64巻 |
| 号 | 1号 |
| 出版者 | Wiley |
| 開始ページ | e15275 |
| ISSN | 1328-8067 |
| NCID | AA11320483 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Japan Pediatric Society. |
| 論文のバージョン | author |
| PubMed ID | 36257617 |
| DOI | 10.1111/ped.15275 |
| Web of Science KeyUT | 000869400500001 |
| 関連URL | isVersionOf https://doi.org/10.1111/ped.15275 |
| フルテキストURL | fulltext20221122-2.pdf |
|---|---|
| 著者 | Tani, Yumeki| Ochiai, Kenta| Kaneta, Takashi| |
| キーワード | Optical force Extracellular vesicle exosome Gold nanoparticle Optical trapping |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s44211-022-00207-2| This full-text will be available in November 2023.| |
| 発行日 | 2022-11-05 |
| 出版物タイトル | Analytical Sciences |
| 巻 | 39巻 |
| 号 | 5号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 643 |
| 終了ページ | 651 |
| ISSN | 0910-6340 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022, The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry |
| 論文のバージョン | author |
| PubMed ID | 36334243 |
| DOI | 10.1007/s44211-022-00207-2 |
| Web of Science KeyUT | 000879131000001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s44211-022-00207-2 |
| フルテキストURL | fulltext20221122-1.pdf |
|---|---|
| 著者 | Nojima, Tsuyoshi| Obara, Takafumi| Yamamoto, Hirotsugu| Yumoto, Tetsuya| Igawa, Takuro| Aokage, Toshiyuki| Seya, Mizuki| Nakao, Atsunori| Naito, Hiromichi| |
| 発行日 | 2022-11 |
| 出版物タイトル | Surgery |
| 巻 | 172巻 |
| 号 | 5号 |
| 出版者 | Elsevier BV |
| 開始ページ | 1522 |
| 終了ページ | 1528 |
| ISSN | 0039-6060 |
| NCID | AA00853880 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Author(s) |
| 論文のバージョン | publisher |
| PubMed ID | 36088170 |
| DOI | 10.1016/j.surg.2022.07.021 |
| Web of Science KeyUT | 000875983900035 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.surg.2022.07.021 |
| フルテキストURL | fulltext20221116-1.pdf |
|---|---|
| 著者 | Takahashi, Misa| Hagiya, Hideharu| Koyama, Toshihiro| Otsuka, Fumio| |
| キーワード | aging sexual health sexually transmitted infection spirochete syphilis |
| 備考 | This is the peer reviewed version of the following article: [Takahashi, M, Hagiya, H, Koyama, T, Otsuka, F. Trends in the incidence of syphilis in the middle-aged and older adults in Japan: A nationwide observational study, 2009–2019. Geriatr. Gerontol. Int. 2022; 22: 1019–1024. https://doi.org/10.1111/ggi.14500], which has been published in final form at [https://doi.org/10.1111/ggi.14500]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This full-text will be available in Nov. 2023.| |
| 発行日 | 2022-11-01 |
| 出版物タイトル | Geriatrics and Gerontology International |
| 巻 | 22巻 |
| 号 | 12号 |
| 出版者 | Wiley |
| 開始ページ | 1019 |
| 終了ページ | 1024 |
| ISSN | 1444-1586 |
| NCID | AA1155729X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Japan Geriatrics Society. |
| 論文のバージョン | author |
| PubMed ID | 36320169 |
| DOI | 10.1111/ggi.14500 |
| Web of Science KeyUT | 000877369900001 |
| 関連URL | isVersionOf https://doi.org/10.1111/ggi.14500 |
| フルテキストURL | fulltext20221110-3.pdf |
|---|---|
| 著者 | Nakano, Yumiko| Taira, Yuki| Sasaki, Ryo| Tadokoro, Koh| Yunoki, Taijun| Nomura, Emi| Fukui, Yusuke| Takemoto, Mami| Morihara, Ryuta| Shimozawa, Nobuyuki| Yamashita, Toru| |
| キーワード | adrenoleukodystrophy symptomatic female carriers spastic paraplegia ABCD1 |
| 備考 | This is the peer reviewed version of the following article: [Nakano, Y, Taira, Y, Sasaki, R, et al. Novel ABCD1 mutation detected in a symptomatic female carrier of adrenoleukodystrophy. Neurol Clin Neurosci. 2023; 11: 58-60. doi: 10.1111/ncn3.12667], which has been published in final form at [https://doi.org/10.1111/ncn3.12667]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| 発行日 | 2022-10-17 |
| 出版物タイトル | Neurology and Clinical Neuroscience |
| 巻 | 11巻 |
| 号 | 1号 |
| 出版者 | Wiley |
| 開始ページ | 58 |
| 終了ページ | 60 |
| ISSN | 2049-4173 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd. |
| 論文のバージョン | author |
| DOI | 10.1111/ncn3.12667 |
| Web of Science KeyUT | 000868833900001 |
| 関連URL | isVersionOf https://doi.org/10.1111/ncn3.12667 |
| フルテキストURL | fulltext20221110-3.pdf |
|---|---|
| 著者 | Shimomae, Koichi| Sato, Takuya| Yoshida, Yuichi| Naing, Shine Shane| Miyatake, Takahisa| |
| キーワード | Diptera Lifespan Pollination Quality control |
| 備考 | © 2022 Korean Society of Applied Entomology. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.aspen.2022.101999] .| This full-text file will be available in Oct. 2023.| |
| 発行日 | 2022-12 |
| 出版物タイトル | Journal of Asia-Pacific Entomology |
| 巻 | 25巻 |
| 号 | 4号 |
| 出版者 | Elsevier BV |
| 開始ページ | 101999 |
| ISSN | 1226-8615 |
| NCID | AA11262547 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Korean Society of Applied Entomology. |
| 論文のバージョン | author |
| DOI | 10.1016/j.aspen.2022.101999 |
| Web of Science KeyUT | 000868905600009 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.aspen.2022.101999 |
| JaLCDOI | 10.18926/AMO/64127 |
|---|---|
| フルテキストURL | 76_6_749.pdf |
| 著者 | Takami, Masanari| Yukawa, Yasutsugu| Noda, Yusuke| Yoshida, Munehito| Yamada, Hiroshi| |
| 抄録 | We provide the first report of successful salvage surgery for a post-C1 laminectomy symptomatic recurrence of a retro-odontoid pseudotumor (ROP) that caused myelopathy. The 72-year-old Japanese woman presented with an ROP causing symptomatic cervical myelopathy. With ultrasonography support, we performed the enucleation of the ROP via a transdural approach and fusion surgery for the recurrence of the mass. At the final observation 2-year post-surgery, MRI demonstrated the mass’s regression and spinal cord decompression, and the patient’s symptoms had improved. Our strategy is an effective option for a symptomatic recurrence of ROP. |
| キーワード | recurrent retro-odontoid pseudotumor salvage surgery transdural resection C1 laminectomy ultra-sonography |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 749 |
| 終了ページ | 754 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549779 |
| Web of Science KeyUT | 000905195100017 |
| JaLCDOI | 10.18926/AMO/64122 |
|---|---|
| フルテキストURL | 76_6_715.pdf |
| 著者 | Mohammed Zahedul Islam Nizami| Gorduysus, Melahat| Shinoda-Ito, Yuki| Yamamoto, Tadashi| Nishina, Yuta| Takashiba, Shogo| Arias, Zulema| |
| 抄録 | The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall. |
| キーワード | bioactive sealer graphene oxide mineral deposition antimicrobial activity radiopacity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 715 |
| 終了ページ | 721 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549774 |
| Web of Science KeyUT | 000905195100012 |
| JaLCDOI | 10.18926/AMO/64121 |
|---|---|
| フルテキストURL | 76_6_705.pdf |
| 著者 | Higashikawa, Toshihiro| Ito, Tomohiko| Mizuno, Takurou| Ishigami, Keiichiro| Kuroki, Kengo| Maekawa, Naoto| Usuda, Daisuke| Izumida, Toshihide| Yamada, Shinya| Sangen, Ryusho| Hamada, Kazu| Kiyosawa, Jun| Saito, Atsushi| Iguchi, Masaharu| Kasamaki, Yuji| Nakahashi, Takeshi| Fukuda, Akihiro| Saito, Hitoshi| Kanda, Tsugiyasu| Okuro, Masashi| |
| 抄録 | The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function. |
| キーワード | tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 705 |
| 終了ページ | 713 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549773 |
| Web of Science KeyUT | 000905195100011 |
| JaLCDOI | 10.18926/AMO/64120 |
|---|---|
| フルテキストURL | 76_6_695.pdf |
| 著者 | Onishi, Hideki| Nouso, Kazuhiro| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Takeuchi, Yasuto| Shiraha, Hidenori| Okada, Hiroyuki| |
| 抄録 | This study sought to identify factors that are predictive of a therapeutic response to hepatic arterial infusion chemotherapy (HAIC) by focusing on the number of prior transcatheter arterial chemoembolization (TACE) sessions. To determine the parameters predicting a good response to HAIC, we retrospectively analyzed 170 patients with hepatocellular carcinoma (HCC) who received HAIC regimens comprising low-dose cisplatin combined with 5-fluorouracil (LFP) or cisplatin (CDDP) for the first time. In both the LFP and CDDP regimens, the response rates were significantly lower in patients with three or more prior TACE sessions than in those with two or fewer prior TACE sessions (LFP 57% versus 28%; p=0.01, CDDP 27% versus 6%; p=0.01). Multivariable logistic regression analysis revealed that the number of prior TACE sessions (≥ 3) was significantly associated with non-responder status (odds ratio 4.17, 95% Confidence Interval (CI) 1.76-9.86) in addition to the HAIC regimen. Multivariable analysis using the Cox proportional hazards model revealed that a larger number of prior TACE sessions (≥ 3) was a significant risk factor for survival (hazard ratio 1.60, 95% CI 1.12-2.29) in addition to Child-Pugh class, serum alpha-fetoprotein concentration, and maximum diameter of HCC. HCC patients who receive fewer prior TACE sessions (≤ 2) were found to be better responders to HAIC. |
| キーワード | hepatic arterial infusion chemotherapy hepatocellular carcinoma refractory transcatheter arterial chemoembolization |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 695 |
| 終了ページ | 703 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549772 |
| Web of Science KeyUT | 000905195100010 |
| JaLCDOI | 10.18926/AMO/64119 |
|---|---|
| フルテキストURL | 76_6_689.pdf |
| 著者 | Yamanouchi, Kosho| Kuba, Sayaka| Matsumoto, Megumi| Yano, Hiroshi| Morita, Michi| Sakimura, Chika| Otsubo, Ryota| Hidaka, Masaaki| Nagayasu, Takeshi| Eguchi, Susumu| |
| 抄録 | Taxanes are key drugs for patients with breast cancer. A major adverse effect of taxanes is peripheral neuropathy (PN). To investigate the ability of compression therapy using sleeves and stockings to prevent PN due to the taxane docetaxel, we conducted a single-center historical control trial. Patients receiving docetaxel at 75 mg/m2 every 3 weeks for 4 cycles as first-line chemotherapy for breast cancer were eligible. PN was evaluated using the common terminology criteria for adverse events version 4.0. The primary endpoint was the incidence of allgrade PN until 3 weeks after the fourth docetaxel administration. We evaluated 26 patients in the intervention group and compared their data to those collected retrospectively from 52 patients treated with docetaxel without compression. Neither the incidence of all-grade PN until 3 weeks after the fourth docetaxel administration (63.5% in the control group vs. 76.9% in the intervention group, p=0.31) nor that of PN grade ≥ 2 (13.5% vs. 15.4%, p=0.99) differed between the groups. In this study, the efficacy of compression therapy using sleeves and stockings to prevent PN induced by docetaxel was not demonstrated. Further clinical studies including medications or intervention are needed to reduce the incidence and severity of PN induced by chemotherapy. |
| キーワード | breast cancer docetaxel neuropathy compression |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 689 |
| 終了ページ | 694 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549771 |
| Web of Science KeyUT | 000905195100009 |
| JaLCDOI | 10.18926/AMO/64118 |
|---|---|
| フルテキストURL | 76_6_679.pdf |
| 著者 | Asagi, Akinori| Sakaguchi, Chihiro| Nadano, Seijin| Nishina, Tomohiro| Hamamoto, Yasushi| Kataoka, Masaaki| Yamashita, Natsumi| Tanimizu, Masahito| Hyodo, Ichinosuke| |
| 抄録 | Chemotherapy is insufficient to treat macroscopic vascular invasion (MVI) of hepatocellular carcinoma (HCC). We retrospectively investigated the treatment outcomes of patients who underwent three-dimensional conformal radiotherapy (3D-CRT) for HCC MVI and analyzed prognostic factors by multivariate analysis using a Cox proportional hazard model. Sixty-five patients were studied. MVI sites were the portal vein (n=48 patients), portal and hepatic veins (n=8), and hepatic vein (n=9). The median irradiation dose was 50 Gy. The median survival time (MST) was 7.5 months. Performance status 2 or 3, modified albumin-bilirubin grade 2b or 3, and massive/diffuse type were poor prognostic factors. Nineteen patients (29%) with a treatment effect of 3 or 4 (≥ 50% of tumor necrosis or regression) at the irradiation sites according to the Response Evaluation Criteria in Cancer of the Liver showed longer survival than those with an effect of 1 or 2 (MST 18.7 vs. 5.9 months, p<0.001). No treatment-related death occurred. The hepatic function reserve was preserved in more than 70% of patients. 3D-CRT controlled HCC MVI safely and was suggested to be a good treatment option. |
| キーワード | hepatocellular carcinoma macroscopic vascular invasion portal vein tumor thrombosis hepatic vein tumor thrombosis three-dimensional conformal radiotherapy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 679 |
| 終了ページ | 688 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549770 |
| Web of Science KeyUT | 000905195100008 |
| JaLCDOI | 10.18926/AMO/64117 |
|---|---|
| フルテキストURL | 76_6_673.pdf |
| 著者 | Okazawa-Sakai, Mika| Yamamoto, Yasuko| Futagawa, Mashu| Okamura, Miki| Miyawaki, Satoko| Nishina, Tomohiro| Takehara, Kazuhiro| Kozuki, Toshiyuki| Tomida, Shuta| Hyodo, Ichinosuke| Ohsumi, Shozo| Hirasawa, Akira| |
| 抄録 | Patients found to have presumed germline pathogenic variants (PGPVs) during comprehensive genomic profiling (CGP) require genetic counseling (GC) referrals. We retrospectively investigated the outcomes of patients with PGPVs. Among 159 patients who underwent CGP, we recommended GC for the 16 patients with PGPVs (3 with [FG group] and 13 without [G Group] a family/personal history of hereditary cancer) as well as for the 8 patients with no PGPVs, but a history (F group); 2 (67%), 5 (38%), and 3 (38%) patients received GC in the FG, G, and F groups, respectively. Germline testing results were positive in 1 and 2 patients of the FG and G groups, respectively. Among the patients recommended for GC, 58% did not receive GC due to lack of interest, poor performance status, or death. CGP contributes to the identification of germline variants in patients without a history of hereditary cancer. However, the proportion of patients who undergo GC should be improved. |
| キーワード | comprehensive genomic profiling hereditary cancer germline findings presumed germline pathogenic variant(s) genetic counseling |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 673 |
| 終了ページ | 678 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549769 |
| Web of Science KeyUT | 000905195100007 |
