検索結果 - 岡山大学学術成果リポジトリ

Efficacy and Safety of Three-dimensional Conformal Radiotherapy for Macroscopic Vascular Invasion of Hepatocellular Carcinoma

JaLCDOI	10.18926/AMO/64118
フルテキストURL	76_6_679.pdf
著者	Asagi, Akinori\| Sakaguchi, Chihiro\| Nadano, Seijin\| Nishina, Tomohiro\| Hamamoto, Yasushi\| Kataoka, Masaaki\| Yamashita, Natsumi\| Tanimizu, Masahito\| Hyodo, Ichinosuke\|
抄録	Chemotherapy is insufficient to treat macroscopic vascular invasion (MVI) of hepatocellular carcinoma (HCC). We retrospectively investigated the treatment outcomes of patients who underwent three-dimensional conformal radiotherapy (3D-CRT) for HCC MVI and analyzed prognostic factors by multivariate analysis using a Cox proportional hazard model. Sixty-five patients were studied. MVI sites were the portal vein (n=48 patients), portal and hepatic veins (n=8), and hepatic vein (n=9). The median irradiation dose was 50 Gy. The median survival time (MST) was 7.5 months. Performance status 2 or 3, modified albumin-bilirubin grade 2b or 3, and massive/diffuse type were poor prognostic factors. Nineteen patients (29%) with a treatment effect of 3 or 4 (≥ 50% of tumor necrosis or regression) at the irradiation sites according to the Response Evaluation Criteria in Cancer of the Liver showed longer survival than those with an effect of 1 or 2 (MST 18.7 vs. 5.9 months, p<0.001). No treatment-related death occurred. The hepatic function reserve was preserved in more than 70% of patients. 3D-CRT controlled HCC MVI safely and was suggested to be a good treatment option.
キーワード	hepatocellular carcinoma macroscopic vascular invasion portal vein tumor thrombosis hepatic vein tumor thrombosis three-dimensional conformal radiotherapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	679
終了ページ	688
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549770
Web of Science KeyUT	000905195100008

Intraoperative Hypothermia Is Not Associated with Surgical Site Infections after Total Hip or Knee Arthroplasty

JaLCDOI	10.18926/AMO/64115
フルテキストURL	76_6_651.pdf
著者	Bright Osman Abugri\| Matsusaki, Takashi\| Ren, Wanxu\| Morimatsu, Hiroshi\|
抄録	Maintaining perioperative normothermia decreases the post-surgery surgical site infection (SSI) rate. We investigated whether SSI is associated with intraoperative hypothermia in total hip (THA) and total knee (TKA) arthroplasties by retrospectively analyzing 297 THA and TKA cases. The patients’ intraoperative core body temperature (BT) was measured by bladder catheter or forehead sensor. We evaluated the associations between SSI and intraoperative BT and other variables and patient characteristics. Fifty-six patients (18.8%) had hypothermia (BT <36°C); 43 developed SSI (14.5%); only five had hypothermia (11.6%). Intraoperative hypothermia and SSI were not significantly associated. The SSI group had more men (34.9% vs. 18.1%) and THA patients (77.4%), a longer mean surgical duration (174.3 vs. 143.5 mins), and a higher average BT (36.4°C vs. 36.2°C) than the no-SSI group. The SSI patients had a higher intraoperative BT. A multivariable analysis revealed that SSI was associated with male sex (OR 2.3, 95%CI: 1.031-4.921, p=0.042), longer surgery (OR, 1.01, 95%CI: 1.003-1.017, p=0.004), THA (OR 3.6, 95%CI: 1.258-10.085, p=0.017), and intraoperative BT >36.0°C (OR 3.6, 95%CI: 1.367-9.475, p=0.009). Intraoperative hypothermia was not associated with SSI in adults who underwent THA or TKA. These results suggest that hypothermia might not be the problem for SSI.
キーワード	hypothermia surgical site infection total hip arthroplasty (THA) knee arthroplasty (TKA)
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	651
終了ページ	660
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549767
Web of Science KeyUT	000905195100005

Fetal Cerebellar Growth Curves Based on Biomathematics in Normally Developing Japanese Fetuses and Fetuses with Trisomy 18

JaLCDOI	10.18926/AMO/64114
フルテキストURL	76_6_645.pdf
著者	Tada, Katsuhiko\| Miyagi, Yasunari\| Komatsu, Reina\| Okimoto, Naoki\| Tsukahara, Saya\| Tateishi, Yoko\| Ooka, Naomi\| Yoshida, Mizuho\| Kumazawa, Kazumasa\|
抄録	We used biomathematics to describe and compare cerebellar growth in normally developing and trisomy 18 Japanese fetuses. This retrospective study included 407 singleton pregnancies with fetuses at 14-39 weeks of gestation and 33 fetuses with trisomy 18 at 17-35 weeks. We used ultrasonography to measure fetal transverse cerebellar diameter (TCD) and anteroposterior cerebellar diameter (APCD). We hypothesized that cerebellar growth is proportional to cerebellar length at any given time point. We determined the formula L(t) ≒Keat+r, where e is Napier’s number, t is time, L is cerebellar length, and a, K, and r are constants. We then obtained regression functions for each TCD and APCD in all fetuses. The regression equations for TCD and APCD values in normal fetuses, expressed as exponential functions, were TCD(t)=27.85e0.02788t−28.62 (mm) (adjusted R2=0.997), and APCD(t)=324.29e0.00286t−322.62 (mm) (adjusted R2=0.995). These functions indicated that TCD and APCD grew at constant rates of 2.788%/week and 0.286%/week, respectively, throughout gestation. TCD (0.0153%/week) and APCD (0.000430%/week) grew more slowly in trisomy 18 fetuses. This study demonstrates the potential of biomathematics in clinical research and may aid in biological understanding of fetal cerebellar growth.
キーワード	biomathematics cerebellum fetus trisomy 18 syndrome ultrasonography
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	645
終了ページ	650
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549766
Web of Science KeyUT	000905195100004

Genital Feminizing Surgery without Vaginoplasty as a Safe, Aesthetic, and Cost-Effective Option for Gender-Affirming Surgery for Transwomen

JaLCDOI	10.18926/AMO/64042
フルテキストURL	76_5_597.pdf
著者	Watanabe, Shiho\| Watanabe, Toshiyuki\| Yamada, Kiyoshi\| Namba, Yuzaburo\| Kimata, Yoshihiro\|
抄録	Gender affirming surgery (GAS) has important impacts for people with gender incongruence (GI), both physically and socially. As the societal acceptance of gender diversity spreads, the number of individuals with GI who wish to be identified as the gender of their choice is increasing. Indeed, many elderly people who have lived a long time with GI now wish to undergo GAS, but face greater surgical risks due to greater burdens of underlying medical conditions. Generally, vaginoplasty is performed for transwomen; however, this surgery is time-consuming and involves heavy bleeding, and thus, should be avoided in elderly people. A less invasive technique is needed. In this article, we describe a new, less invasive genital feminizing surgical technique for transwomen with reports from two clinical cases. We present this novel technique as a safe, aesthetic, and cost-effective option for gender-affirming surgery for transwomen.
キーワード	gender-affirming surgery, vaginoplasty gender incongruence transwomen
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	597
終了ページ	603
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352808
Web of Science KeyUT	000884907100014

COVID-19 Vaccine-Associated Lymphadenopathy Mimicking Regrowth of Axillary Lymph Node Metastasis of Lung Adenocarcinoma

JaLCDOI	10.18926/AMO/64041
フルテキストURL	76_5_593.pdf
著者	Noumi, Taku\| Watanabe, Hiromi\| Ninomiya, Kiichiro\| Ohashi, Kadoaki\| Ichihara, Eiki\| Kubo, Toshio\| Makimoto, Go\| Kato, Yuka\| Fujii, Masanori\| Tabata, Masahiro\| Maeda, Yoshinobu\| Hotta, Katsuyuki\| Kiura, Katsuyuki\|
抄録	We encountered a woman with re-enlarged axillary lymph nodes during a computed tomography (CT) scan for surveillance of lung adenocarcinoma with axillary lymph node metastasis at the initial diagnosis that had shrunk with standard chemotherapy. We first suspected cancer recurrence and considered a change in the chemotherapeutic regimen. However, after careful history taking regarding the timing of her Coronavirus Disease 2019 (COVID-19) vaccination, and subsequent careful, close follow-up, radiological shrinkage suggested a strictly benign cause. Especially in lung cancer with a medical history of axillary lymph node involvement, cliniciansshould be aware that vaccine-associated lymphadenopathy can mimic cancer recurrence and sometimesprompt serious misjudgment regarding a current treatment course and strategy.
キーワード	lung cancer COVID-19 vaccination axillary lymphadenopathy case report
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	593
終了ページ	596
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352807
Web of Science KeyUT	000884907100013

First-line Combination Strategy Provides Favorable 5-year Outcomes for Patients with Lupus Nephritis: A Single-center Observational Study

JaLCDOI	10.18926/AMO/64036
フルテキストURL	76_5_547.pdf
著者	Kagawa, Hidetoshi\| Yamanaka, Ryutaro\| Hiromasa, Tsutomu\|
抄録	This observational study aimed to clarify the long-term results of the combination of mizoribine (MZB), tacrolimus (TAC) and prednisolone as first-line therapy for lupus nephritis (LN). This was our institution’s standard therapy between 2009 and 2015, when we saw 36 patients with LN. When a patient thus treated achieved SLEDAI remission (= 0) and/or the prednisolone dose could be tapered to 5 mg/day, either MZB or TAC was stopped, and the other was continued for maintenance therapy. If treatment failure or relapse occurred, second-line therapy was introduced. At years 1 and 5, overall complete renal response and SLEDAI remission were 94% and 88%, and 50% and 62%, respectively. Excluding 2 cases lost to follow-up, medications after 5 years were as follows: 20 (59%) were stable on 1 drug (MZB or TAC), 11 (32%) required continuation of both drugs (MZB + TAC), and 3 (9%) required second-line therapy. The 5-year retention rate was 91% (non-secondline), with 0% of relapse in this group. Our first-line combination strategy showed high remission rates in the induction phase, and subsequent maintenance therapy demonstrated good outcomes for up to 5 years. Research that fine-tunes the order of therapeutic agents and institutes appropriate treatment goals may further improve long-term outcomes for patients with LN.
キーワード	combination therapy first-line therapy lupus nephritis mizoribine tacrolimus
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	547
終了ページ	555
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352802
Web of Science KeyUT	000884907100008

Current Insights into Mesenchymal Signatures in Glioblastoma

JaLCDOI	10.18926/AMO/64024
フルテキストURL	76_5_489.pdf
著者	Matsumoto, Yuji\| Ichikawa, Tomotsugu\| Kurozumi, Kazuhiko\| Date, Isao\|
抄録	Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives.
キーワード	glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	489
終了ページ	502
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352795
Web of Science KeyUT	000884907100001

Histamine induced high mobility group box-1 release from vascular endothelial cells through H-1 receptor

フルテキストURL	fulltext.pdf
著者	Gao, Shangze\| Liu, Keyue\| Ku, Wenhan\| Wang, Dengli\| Wake, Hidenori\| Qiao, Handong\| Teshigawara, Kiyoshi\| Nishibori, Masahiro\|
キーワード	Histamine HMGB1 vascular endothelial cell H-1 receptor hypotension
発行日	2022-10-05
出版物タイトル	Frontiers In Immunology
巻	13巻
出版者	Frontiers Media SA.
開始ページ	930683
ISSN	1664-3224
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Gao, Liu, Ku, Wang, Wake, Qiao, Teshigawara and Nishibori.
論文のバージョン	publisher
PubMed ID	36275732
DOI	10.3389/fimmu.2022.930683
Web of Science KeyUT	000873745300001
関連URL	isVersionOf https://doi.org/10.3389/fimmu.2022.930683

A Static Assignment Algorithm of Uniform Jobs to Workers in a User-PC Computing System Using Simultaneous Linear Equations

フルテキストURL	fulltext.pdf
著者	Zhou, Xudong\| Funabiki, Nobuo\| Htet, Hein\| Kamoyedji, Ariel\| Anggraini, Irin Tri\| Huo, Yuanzhi\| Syaifudin, Yan Watequlis\|
キーワード	UPC distributed computing platform uniform job static assignment linear equations
発行日	2022-10-07
出版物タイトル	Algorithms
巻	15巻
号	10号
出版者	MDPI
開始ページ	369
ISSN	1999-4893
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
DOI	10.3390/a15100369
Web of Science KeyUT	000872102600001
関連URL	isVersionOf https://doi.org/10.3390/a15100369

Bilateral verses bilateral with tri-segmental endoscopic drainage using metal stents for high-grade malignant hilar biliary obstructions: A multicenter, randomized controlled trial: BRAVE study (BRAVE study)

フルテキストURL	fulltext.pdf
著者	Matsumoto, Kazuyuki\| Mitsuhashi, Toshiharu\| Kawamoto, Hirofumi\| Ishida, Etsuji\| Fujii, Masakuni\| Akimoto, Yutaka\| Seki, Hiroyuki\| Ishihara, Yuki\| Ogawa, Taiji\| Yamazaki, Tatsuhiro\| Fujii, Yuki\| Kato, Hironari\|
キーワード	bilateral drainage bile duct obstruction endoscopic biliary drainage neoplasms self-expandable metallic stents
発行日	2022-10-07
出版物タイトル	Medicine
巻	101巻
号	40号
出版者	Lippincott Williams & Wilkins
開始ページ	e30857
ISSN	0025-7974
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 the Author(s).
論文のバージョン	publisher
PubMed ID	36221399
DOI	10.1097/MD.0000000000030857
Web of Science KeyUT	000865518700110
関連URL	isVersionOf https://doi.org/10.1097/MD.0000000000030857

Impact of Different KDIGO Criteria on Clinical Outcomes for Early Identification of Acute Kidney Injury after Non-Cardiac Surgery

フルテキストURL	fulltext.pdf
著者	Fu, Jingwen\| Kosaka, Junko\| Morimatsu, Hiroshi\|
キーワード	acute kidney injury KDIGO definition serum creatine urine output early identification
発行日	2022-09-23
出版物タイトル	JOURNAL OF CLINICAL MEDICINE
巻	11巻
号	19号
出版者	MDPI
開始ページ	5589
ISSN	2077-0383
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	36233456
DOI	10.3390/jcm11195589
Web of Science KeyUT	000867903000001
関連URL	isVersionOf https://doi.org/10.3390/jcm11195589

Site-specific differences in T lymphocyte composition of the gastric mucosa after Helicobacter pylori eradication

フルテキストURL	fulltext.pdf
著者	Iwamuro, Masaya\| Takahashi, Takahide\| Watanabe, Natsuki\| Abe, Makoto\| Sakae, Hiroyuki\| Kono, Yoshiyasu\| Kanzaki, Hiromitsu\| Tanaka, Takehiro\| Kawano, Seiji\| Otsuka, Fumio\| Kawahara, Yoshiro\| Yanai, Hiroyuki\| Okada, Hiroyuki\|
キーワード	eradication flow cytometry Helicobacter pylori T lymphocytes
発行日	2022-08-26
出版物タイトル	Medicine
巻	101巻
号	34号
出版者	Lippincott Williams & Wilkins
開始ページ	e30241
ISSN	0025-7974
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 the Author(s).
論文のバージョン	publisher
PubMed ID	36042652
DOI	10.1097/MD.0000000000030241
Web of Science KeyUT	000847532100050
関連URL	isVersionOf https://doi.org/10.1097/MD.0000000000030241

Molecular-targeted Therapy for Metastatic Renal Cell Carcinoma As First-line Therapy: A Single Institution 13-year Experience

JaLCDOI	10.18926/AMO/63906
フルテキストURL	76_4_465.pdf
著者	Bekku, Kensuke\| Tsugawa, Takuji\| Tsuboi, Kazuma\| Noda, Gaku\| Inoue, Yousuke\| Murao, Wataru\| Ebara, Shin\|
抄録	We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint. Survival was compared using the log-rank test. A total of 108 patients were retrospectively analyzed. The numbers of patients in the favorable-, intermediate-, and poor-risk groups were 32 (30%), 66 (61%), and 10 (9%), repestively. The median OS values in the entire cohort was 36 months (95% confidence interval [CI] 29-53). The median OS in the favorable, intermediate, and poor risk groups were 94 months (95% CI: 43-Not reached), 30 months (95% CI: 20-38), and 8 months (95% CI: 0-Not reached), respectively (p<0.05). Prior nephrectomy, clear cell histology, clinical T stage ≤2, no metastasis at the time of diagnosis, nivolumab beyond first-line therapy, and objective response to VEGFR-TKIs were factors significantly prolonging OS on univariate analysis. VEGFR-TKI monotherapy as first-line therapy was an effective treatment option for patients with metastatic clear cell RCC with favorable risk.
キーワード	metastatic renal cell carcinoma molecular-targeted therapy immuno-checkpoint inhibitor real-world setting
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	465
終了ページ	472
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123162

Postoperative Urinary Retention in Japanese Elderly Males with a Femoral Neck or Trochanteric Fracture

JaLCDOI	10.18926/AMO/63895
フルテキストURL	76_4_409.pdf
著者	Higashikawa, Toshihiro\| Shigemoto, Kenji\| Goshima, Kenichi\| Iwai, Shintarou\| Moriyama, Manabu\| Usuda, Daisuke\| Hangyou, Masahiro\| Inujima, Hiromi\| Nozaki, Kakeru\| Yamaguchi, Miyako\| Usuda, Kimiko\| Nakahashi, Takeshi\| Matsumoto, Tadami\| Takashima, Shigeki\| Kanda, Tsugiyasu\| Horii, Takeshi\| Okuro, Masashi\| Sawaguchi, Takeshi\|
抄録	We assessed risk factors for postoperative urinary retention (UR) in elderly males with femoral bone fractures: 169 Japanese males (mean age 81.95 ± 1.19 years) who had undergone hip surgery at a municipal hospital (Toyama, Japan). A multiple logistic regression analysis was used to test possible risk factors for UR: age, body mass index, serum albumin, cognitive impairment, activities of daily living (ADL), and history of diabetes mellitus (DM). UR occurred in 24 (14.2%) of the 169 patients. A multivariate logistic regression analysis with age adjustment showed that ADL (odds ratio [OR] 3.88; 95% confidence interval [CI]: 1.2-12.5, p=0.023) was significantly associated with the development of UR, and a history of DM showed marginal significance for UR occurrence (OR 0.36, 95%CI: 0.11-10, p=0.064). These results suggests that ADL is a risk factor for UR development in elderly males who have undergone surgery for femoral neck or trochanter fractures.
キーワード	elderly femoral bone fracture albumin urinary retention activities of daily living
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	409
終了ページ	414
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123155
Web of Science KeyUT	000882167300006

Effects of Tanden Breathing on Constipation: A Randomized Controlled Trial

JaLCDOI	10.18926/AMO/63893
フルテキストURL	76_4_391.pdf
著者	Habu, Hiroshi\| Mitsuhashi, Toshiharu\| Tokinobu, Akiko\| Yorifuji, Takashi\| Takao, Soshi\|
抄録	Tanden breathing, an ancient health technique, involves expiratory abdominal pressure breathing is practiced in Japan. In this study we examined the ability of Tanden breathing to relieve constipation. The study was designed as a stratified-block randomized controlled trial enrolling 20 participants. Nineteen were female and one was male, none were elderly. During the 6-week intervention period, the participants performed video-guided Tanden breathing about 10 min once day. We evaluated constipation using the Constipation Assessment Scale (CAS). There were significant differences in the mean CAS score between time points (baseline, 3 weeks after baseline, 6 weeks after baseline), groups (intervention and control), and their interaction (time×group) using repeated-measures analysis of variance. The control group showed no change in the mean CAS score; the mean CAS scores of the intervention group changed from 7.2 at baseline to 3.9 at 3 weeks and 3.1 at 6 weeks after baseline. A regression analysis of the difference in the mean CAS between baseline and 6 weeks later showed that the CAS of the intervention group was 4.3 points lower than that of the control group (95% confidence interval, 2.5-6.1). The results suggested that Tanden breathing is effective in relieving constipation among young women.
キーワード	Tanden breathing Dantian breathing exercises constipation mind−body therapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	391
終了ページ	398
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123153
Web of Science KeyUT	000882167300001

Central and Enteric Neuroprotective Effects by Eucommia ulmoides Extracts on Neurodegeneration in Rotenone-induced Parkinsonian Mouse

JaLCDOI	10.18926/AMO/63889
フルテキストURL	76_4_373.pdf
著者	Imafuku, Fuminori\| Miyazaki, Ikuko\| Sun, Jin\| Kamimai, Sunao\| Shimizu, Takashi\| Toyota, Toshiaki\| Okamoto, Yusei\| Isooka, Nami\| Kikuoka, Ryo\| Kitamura, Yoshihisa\| Asanuma, Masato\|
抄録	Parkinson’s disease (PD) is a progressive neurodegenerative disease of both the central and peripheral / enteric nervous systems. Oxidative stress and neuroinflammation are associated with the pathogenesis of PD, suggesting that anti-oxidative and anti-inflammatory compounds could be neuroprotective agents for PD. Eucommia ulmoides (EU) is a traditional herbal medicine which exerts neuroprotective effects by anti-inflammatory and anti-oxidative properties. Our previous study showed that treatment with chlorogenic acid, a component of EU, protected against neurodegeneration in the central and enteric nervous systems in a PD model. In this study, we examined the effects of EU extract (EUE) administration on dopaminergic neurodegeneration, glial response and α-synuclein expression in the substantia nigra pars compacta (SNpc), and intestinal enteric neurodegeneration in low-dose rotenone-induced PD model mice. Daily oral administration of EUE ameliorated dopaminergic neurodegeneration and α-synuclein accumulation in the SNpc. EUE treatment inhibited rotenone- induced decreases in the number of total astrocytes and in those expressing the antioxidant molecule metallothionein. EUE also prevented rotenone-induced microglial activation. Furthermore, EUE treatment exerted protective effects against intestinal neuronal loss in the PD model. These results suggest that EU exerts neuroprotective effects in the central and enteric nervous systems of rotenone-induced parkinsonism mice, in part by glial modification.
キーワード	Eucommia ulmoides dopamine neuron enteric neuron glia Parkinson’s disease
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	373
終了ページ	383
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123151
Web of Science KeyUT	000882167300003

Correlation between national surveillance and search engine query data on respiratory syncytial virus infections in Japan

フルテキストURL	fulltext.pdf
著者	Uda, Kazuhiro\| Hagiya, Hideharu\| Yorifuji, Takashi\| Koyama, Toshihiro\| Tsuge, Mitsuru\| Yashiro, Masato\| Tsukahara, Hirokazu\|
キーワード	RSV Surveillance Google Trends Epidemiology
発行日	2022-08-09
出版物タイトル	BMC Public Health
巻	22巻
号	1号
出版者	BMC
開始ページ	1517
ISSN	1471-2458
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35945532
DOI	10.1186/s12889-022-13899-y
Web of Science KeyUT	000838077700004
関連URL	isVersionOf https://doi.org/10.1186/s12889-022-13899-y

Efficacy of soft palatal augmentation prosthesis for oral functional rehabilitation in patients with dysarthria and dysphagia: a protocol for a randomised controlled trial

フルテキストURL	fulltext.pdf
著者	Yokoyama, Tomonori\| Mukai, Takao\| Kodama, Naoki\| Takao, Kana\| Hiraoka, Takashi\| Arai, Nobuyuki\| Yano, Jitsuro\| Nagatsuka, Hiroaki\| Manda, Yousuke\| Hanayama, Kozo\| Minagi, Shogo\|
キーワード	oral medicine rehabilitation medicine geriatric medicine
発行日	2022-07-14
出版物タイトル	BMJ Open
巻	12巻
号	7号
出版者	BMJ Publishing Group
開始ページ	e060040
ISSN	2044-6055
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Author(s) (or their employer(s)) 2022.
論文のバージョン	publisher
PubMed ID	35835521
DOI	10.1136/bmjopen-2021-060040
Web of Science KeyUT	000826598000008
関連URL	isVersionOf https://doi.org/10.1136/bmjopen-2021-060040

Reproduction of the Antitumor Effect of Cisplatin and Cetuximab Using a Three-dimensional Spheroid Model in Oral Cancer

フルテキストURL	fulltext.pdf
著者	Ono, Kisho\| Sato, Kohei\| Nakamura, Tomoya\| Yoshida, Yume\| Murata, Shogo\| Yoshida, Kunihiro\| Kanemoto, Hideka\| Umemori, Koki\| Kawai, Hotaka\| Obata, Kyoichi\| Ryumon, Shoji\| Hasegawa, Kazuaki\| Kunisada, Yuki\| Okui, Tatsuo\| Ibaragi, Soichiro\| Nagatsuka, Hitoshi\| Sasaki, Akira\|
キーワード	oral cancer spheroid three-dimensional culture anticancer drug
発行日	2022-07-18
出版物タイトル	International Journal Of Medical Sciences
巻	19巻
号	8号
出版者	Ivyspring International Publisher
開始ページ	1320
終了ページ	1333
ISSN	1449-1907
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The author(s).
論文のバージョン	publisher
PubMed ID	35928727
DOI	10.7150/ijms.74109
Web of Science KeyUT	000830781500011
関連URL	isVersionOf https://doi.org/10.7150/ijms.74109

Histidine-rich glycoprotein as a novel predictive biomarker of postoperative complications in intensive care unit patients: a prospective observational study

フルテキストURL	fulltext.pdf
著者	Oiwa, Masahiko\| Kuroda, Kosuke\| Kawanoue, Naoya\| Morimatsu, Hiroshi\|
キーワード	Biomarker Clavien-Dindo classification Histidine-rich glycoprotein Intensive care unit Perioperative management Postoperative complication Predictor
発行日	2022-07-20
出版物タイトル	BMC Anesthesiology
巻	22巻
号	1号
出版者	BMC
開始ページ	232
ISSN	1471-2253
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35858852
DOI	10.1186/s12871-022-01774-7
Web of Science KeyUT	000828247900001
関連URL	isVersionOf https://doi.org/10.1186/s12871-022-01774-7