検索結果 - 岡山大学学術成果リポジトリ

Detection of Membrane Potential-Dependent Rhodopsin Fluorescence Using Low-Intensity Light Emitting Diode for Long-Term Imaging

フルテキストURL	fulltext.pdf
著者	Kawanishi, Shiho\| Kojima, Keiichi\| Shibukawa, Atsushi\| Sakamoto, Masayuki\| Sudo, Yuki\|
発行日	2023-01-25
出版物タイトル	ACS Omega
巻	8巻
出版者	American Chemical Society
開始ページ	4826
終了ページ	4834
ISSN	2470-1343
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	36777568
DOI	10.1021/acsomega.2c06980
Web of Science KeyUT	000926216100001
関連URL	isVersionOf https://doi.org/10.1021/acsomega.2c06980

Analysis of Phase Angle and Balance and Gait Functions in Pre-Frail Individuals: A Cross-Sectional Observational Study

JaLCDOI	10.18926/AMO/64357
フルテキストURL	77_1_21.pdf
著者	Homma, Daisuke\| Minato, Izumi\| Imai, Norio\| Miyasaka, Dai\| Sakai, Yoshinori\| Horigome, Yoji\| Suzuki, Hayato\| Dohmae, Yoichiro\| Endo, Naoto\|
抄録	We measured the muscle mass and phase angle of each body part to evaluate the relationship between balance and gait functions in individuals with a pre-frailty status. This cross-sectional observational study determined the skeletal muscle mass-to-body weight ratio and phase angles of 21 control (robust) and 29 pre-frail subjects. Their Brief-Balance Evaluation Systems Test, Timed Up-and-Go (TUG) test, Life-Space Assessment, and Modified Fall Efficacy Scale scores plus the relationship between muscle mass, phase angle, and motor function were evaluated. In the pre-frailty group (three males, 26 females, aged 75.58±7.60 years), significant correlations were noted between the Brief-Balance Evaluation Systems Test score and lower-limb (r=0.614) and wholebody (r=0.557) phase angles, and between the TUG test score and lower-limb muscle mass-to-body weight ratio (r=−0.616), lower-limb phase angle (r=−0.616), and whole-body phase angle (r=−0.527). Evaluating the phase angle of the lower extremities of pre-frail patients and intervening accordingly may help clinicians maintain and improve these patients’ balance and gait functions.
キーワード	bioelectrical impedance analysis motor function muscle quality muscle volume
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-02
巻	77巻
号	1号
出版者	Okayama University Medical School
開始ページ	21
終了ページ	27
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36849142
Web of Science KeyUT	000953663800003

Safety and Efficacy of a Well-Fitting Brassiere after Breast Reconstruction: A Qualitative Study

JaLCDOI	10.18926/AMO/64356
フルテキストURL	77_1_11.pdf
著者	Watanabe, Satoko\| Saiga, Miho\| Motoki, Takayuki\| Shien, Tadahiko\| Taira, Naruto\| Doihara, Hiroyoshi\| Kimata, Yoshihiro\|
抄録	The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction.
キーワード	breast reconstruction mastectomy brassiere professional bra fitter
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-02
巻	77巻
号	1号
出版者	Okayama University Medical School
開始ページ	11
終了ページ	19
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36849141
Web of Science KeyUT	000953663800002

時間の「起源」―ライプニッツのデ・フォルダー宛書簡から―

JaLCDOI	10.18926/64335
タイトル（別表記）	“Origins” of Time in Leibniz from His Letters to De Volder
フルテキストURL	scs_022_035.pdf
著者	松田毅\|
抄録	本稿は2021年7月3日にオンラインで開催された、第4回Congresso ibero americano Leibniz, Mexicoで““Origins” of time in Leibniz from his letters to De Volder”と題して、筆者が発表したものを改稿したものである。
出版物タイトル	文化共生学研究
発行日	2022-12-23
巻	22巻
開始ページ	35
終了ページ	54
ISSN	1880-9162
言語	日本語
著作権者	Copyright © 2022 岡山大学大学院社会文化科学研究科
論文のバージョン	publisher

A method for reconstruction of interpretable brain networks from transient synchronization in resting-state BOLD fluctuations

フルテキストURL	fulltext.pdf
著者	Noro, Yusuke\| Li, Ruixiang\| Matsui, Teppei\| Jimura, Koji\|
キーワード	resting-state fMRI task fMRI temporal dynamics individual difference Human Connectome Project
発行日	2023-01-12
出版物タイトル	Frontiers In Neuroinformatics
巻	16巻
出版者	Frontiers Media
開始ページ	960607
ISSN	1662-5196
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Noro, Li, Matsui and Jimura.
論文のバージョン	publisher
PubMed ID	36713290
DOI	10.3389/fninf.2022.960607
Web of Science KeyUT	000918473200001
関連URL	isVersionOf https://doi.org/10.3389/fninf.2022.960607

Reliability of the Garden Alignment Index and Valgus Tilt Measurement for Nondisplaced Femoral Neck Fractures

フルテキストURL	fulltext.pdf
著者	Yamakawa, Yasuaki\| Yamamoto, Norio\| Tomita, Yosuke\| Okuda, Ryuichiro\| Masada, Yasutaka\| Shiroshita, Akihiro\| Matsumoto, Toshiyuki\|
キーワード	femoral neck fracture intracapsular hip fracture Garden alignment index posterior tilt inter-rater reliability intra-rater reliability intraclass correlation coefficients
発行日	2022-12-27
出版物タイトル	Journal Of Personalized Medicine
巻	13巻
号	1号
出版者	MDPI
開始ページ	53
ISSN	2075-4426
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	36675714
DOI	10.3390/jpm13010053
Web of Science KeyUT	000915393000001
関連URL	isVersionOf https://doi.org/10.3390/jpm13010053

Surgical Techniques of Gastrojejunostomy in Robotic Pancreatoduodenectomy: Robot-Sewn versus Stapled Gastrojejunostomy Anastomosis

フルテキストURL	fulltext.pdf
著者	Takagi, Kosei\| Umeda, Yuzo\| Yoshida, Ryuichi\| Fuji, Tomokazu\| Yasui, Kazuya\| Kimura, Jiro\| Hata, Nanako\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
キーワード	pancreatoduodenectomy robotic surgery gastrojejunostomy delayed gastric emptying
発行日	2023-01-16
出版物タイトル	Journal Of Clinical Medicine
巻	12巻
号	2号
出版者	MDPI
開始ページ	732
ISSN	2077-0383
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	36675661
DOI	10.3390/jcm12020732
Web of Science KeyUT	000914818600001
関連URL	isVersionOf https://doi.org/10.3390/jcm12020732

Sequential Combination of FLAM and Venetoclax plus Azacitidine to Bridge to Cord Blood Transplantation in a Patient with Primary Induction Failure Acute Myeloid Leukemia

フルテキストURL	fulltext.pdf
著者	Murakami, Hiroyuki\| Matsuoka, Ken-Ichi\| Asano, Takeru\| Moriyama, Takashi\| Matsumura, Akifumi\| Fujiwara, Hideaki\| Asada, Noboru\| Ennishi, Daisuke\| Nishimori, Hisakazu\| Fujii, Keiko\| Fujii, Nobuharu\| Toji, Tomohiro\| Yoshino, Tadashi\| Maeda, Yoshinobu\|
キーワード	Refractory acute myeloid leukemia Transplant B-cell lymphoma-2 Azacitidine Venetoclax
発行日	2022-11-08
出版物タイトル	Case Reports In Oncology
巻	15巻
号	3号
出版者	Karger
開始ページ	974
終了ページ	979
ISSN	1662-6575
NCID	AA12780955
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Author(s).
論文のバージョン	publisher
PubMed ID	36636684
DOI	10.1159/000526697
Web of Science KeyUT	000905485600025
関連URL	isVersionOf https://doi.org/10.1159/000526697

Examining the association between vaccine reactogenicity and antibody titer dynamics after the third dose of BNT162b2 vaccine using a mixed-effects model

フルテキストURL	fulltext20230112-4.pdf figures20230112-4.pdf online-supplemental-figures20230112-4.pdf online-supplemental-Tables20230112-4.pdf
著者	Matsumoto, Naomi\| Hagiya, Hideharu\| Nakayama, Masanori\| Furukawa, Masanori\| Mitsuhashi, Toshiharu\| Takao, Soshi\| Otsuka, Fumio\| Yorifuji, Takashi\|
キーワード	SARS-CoV-2 Vaccine Antibody Reactogenicity Adverse reaction Mixed-effects model
備考	© 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.09.012] . \| This full-text file will be available in Nov. 2023.\|
発行日	2022-11-12
出版物タイトル	Journal of Infection and Chemotherapy
巻	29巻
号	1号
出版者	Elsevier BV
開始ページ	39
終了ページ	42
ISSN	1341-321X
NCID	AA11057978
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases
論文のバージョン	author
PubMed ID	36168999
DOI	10.1016/j.jiac.2022.09.012
Web of Science KeyUT	000894818300007
関連URL	isVersionOf https://doi.org/10.1016/j.jiac.2022.09.012

Judicial barriers to inclusive education as a human right: An analysis of relevant legal cases in Japan

フルテキストURL	fulltext20230112-1.pdf
著者	Yoshitoshi, Munehisa\| Horiguchi, Goro\| Takahashi, Kiriko\|
キーワード	Human rights inclusive education court litigation reasonable accommodation symbiotic society
備考	This is an Accepted Manuscript of an article published by Taylor & Francis in [Disability & Society] on [2022-12-16], available online: http://www.tandfonline.com/10.1080/09687599.2022.2157705\| This full-text file will be available in June 2024.\|
発行日	2022-12-16
出版物タイトル	Disability & Society
巻	39巻
号	6号
出版者	Informa UK Limited
開始ページ	1423
終了ページ	1442
ISSN	0968-7599
NCID	AA10993999
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
DOI	10.1080/09687599.2022.2157705
Web of Science KeyUT	000898598900001
関連URL	isVersionOf https://doi.org/10.1080/09687599.2022.2157705

Characteristics of Sleep Disturbance in Patients with Long COVID: A Retrospective Observational Study in Japan

フルテキストURL	fulltext.pdf
著者	Sunada, Naruhiko\| Nakano, Yasuhiro\| Otsuka, Yuki\| Tokumasu, Kazuki\| Honda, Hiroyuki\| Sakurada, Yasue\| Matsuda, Yui\| Hasegawa, Toru\| Omura, Daisuke\| Ochi, Kanako\| Hagiya, Hideharu\| Ueda, Keigo\| Kataoka, Hitomi\| Otsuka, Fumio\|
キーワード	insomnia myalgic encephalomyelitis chronic fatigue long COVID Omicron variant post COVID-19 condition
発行日	2022-12-09
出版物タイトル	Journal Of Clinical Medicine
巻	11巻
号	24号
出版者	MDPI
開始ページ	7332
ISSN	2077-0383
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	36555948
DOI	10.3390/jcm11247332
Web of Science KeyUT	000901154300001
関連URL	isVersionOf https://doi.org/10.3390/jcm11247332

Endoscopic treatment for duodenal perforation due to biliary stent dislocation: A case report and brief review of the literature

フルテキストURL	fulltext.pdf
著者	Fujii, Yuki\| Matsumoto, Kazuyuki\| Miyamoto, Kazuya\| Matsumi, Akihiro\| Morimoto, Kosaku\| Terasawa, Hiroyuki\| Yamazaki, Tatsuhiro\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Kato, Hironari\|
キーワード	biliary stent endoscope migration perforation
発行日	2022-12-02
出版物タイトル	MEDICINE
巻	101巻
号	48号
出版者	LIPPINCOTT WILLIAMS & WILKINS
開始ページ	e31868
ISSN	0025-7974
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 the Author(s).
論文のバージョン	publisher
PubMed ID	36482637
DOI	10.1097/MD.0000000000031868
Web of Science KeyUT	000895502600121
関連URL	isVersionOf https://doi.org/10.1097/MD.0000000000031868

岡山大学構内遺跡における水田稲作の開始年代 ―Ⅰ期中段階の堰の酸素同位体比年輪年代と炭素14年代―

タイトル（別表記）	The beginning date of wet rice cultivation at the of Okayama University site: Tree ring oxygen isotope dating and radiocarbon 14 age of weirs from the mid-I stage of the Yayoi period
JaLCDOI	10.18926/64199
フルテキストURL	jdc_002_018.pdf
著者	藤尾慎一郎\| 坂本稔\| 佐野雅規\|
抄録	This article clarifies the date when paddy field rice cultivation began at the archaeological site located within the Okayama University campus. The analysis used tree ring oxygen isotope dating and radiocarbon dating. When the oxygen isotope ratios of wood used in paddy weirs detected in the 23rd excavation season were examined, peaks could be seen in two places: in the 10th century BC and the 6th century BC. Since the weir was accompanied by mid-I stage Yayoi pottery, which was dated to the 6th century BC using radiocarbon dating, tree ring dating determined that the weir was made from wood cut down soon after 540 BC. Therefore, it was reaffirmed that one of the points of the mid-I stage can be dated to the middle of the 6th century BC. Next is the age of the early-I stage, when paddy field rice cultivation began on the Okayama Plain. In the Tsuruba area of the Nishikawazu archaeological site in Shimane Prefecture, where paddy field rice cultivation is thought to have begun at the same time as on the Okayama Plain, tree ring oxygen isotope dating of wood accompanied by early-I stage pottery has been reported. The date of 649 BC date means that one of the earliest stages of the early-I period dates to the middle of the 7th century BC. Therefore, we reaffirmed the view that paddy rice cultivation in the Chugoku region, such as Okayama and Shimane, began in the 7th century BC. It also became clear that the beginning of paddy field rice cultivation in the Chugoku region occurred at a time when the climate that had been the base of cold in the 10th century BC gradually warmed and the relatively humid climate began to turn to arid.
キーワード	土器付着炭化物：carbides adhering to pottery 酸素同位体比年輪年代法：tree ring oxygen isotope dating 炭素14年代法：radiocarbon dating 岡山大学構内遺跡：the Okayama University site 弥生前期：the early Yayoi period 水田稲作：wet rice cultivation 堰：weirs
Amo Type	研究ノート (Research note)
出版物タイトル	文明動態学
発行日	2023-03-25
巻	2巻
出版者	岡山大学文明動態学研究所
開始ページ	18
終了ページ	31
ISSN	2436-8326
資料タイプ	学術雑誌論文
言語	日本語
著作権者	© 2023 by RIDC
論文のバージョン	publisher

A Throughput Request Satisfaction Method for Concurrently Communicating Multiple Hosts in Wireless Local Area Network

フルテキストURL	fulltext.pdf
著者	Rahman, Md Mahbubur\| Funabiki, Nobuo\| Munene, Kwenga Ismael\| Roy, Sujan Chandra\| Kuribayashi, Minoru\| Gulo, Melki Mario\| Kao, Wen-Chung\|
キーワード	Raspberry Pi WLAN traffic shaping access point fairness throughput request
発行日	2022-11-15
出版物タイトル	Sensors
巻	22巻
号	22号
出版者	MDPI
開始ページ	8823
ISSN	1424-8220
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	36433419
DOI	10.3390/s22228823
Web of Science KeyUT	000887819400001
関連URL	isVersionOf https://doi.org/10.3390/s22228823

Are Prophylactic Systemic Antibiotics Required in Patients with Cataract Surgery at Local Anesthesia?

フルテキストURL	fulltext20221130-1.pdf
著者	Matsuo, Toshihiko\| Iguchi, Masahiro\| Morisato, Noriyasu\| Murasako, Tatsuya\| Hagiya, Hideharu\|
キーワード	cataract surgery global action plan antimicrobial resistance appropriate use antibiotics oral intravenous topical povidone iodine conjunctival sac culture
発行日	2022-11-27
出版物タイトル	International Journal of Environmental Research and Public Health
巻	19巻
号	23号
出版者	MDPI AG
開始ページ	15796
ISSN	1660-4601
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
DOI	10.3390/ijerph192315796

Acute and Prolonged Effects of Dermal Suction on Joint Range of Motion and Passive Muscle Stiffness: A Preliminary Study

フルテキストURL	fulltext.pdf
著者	Enomoto, Shota\| Shibutani, Tomonari\| Akihara, Yu\| Yamada, Kazunori\| Oda, Toshiaki\|
キーワード	elastography flexibility rectus femoris shear wave velocity range of motion ultrasound vastus lateralis
発行日	2022-11-09
出版物タイトル	Healthcare
巻	10巻
号	11号
出版者	MDPI
開始ページ	2241
ISSN	2227-9032
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	36360582
DOI	10.3390/healthcare10112241
Web of Science KeyUT	000883952500001
関連URL	isVersionOf https://doi.org/10.3390/healthcare10112241

消費者行動研究における世帯消費に関する研究の再検討－家事の外部化市場の伸長と共働き化の関係に関する考察－

JaLCDOI	10.18926/OER/64161
タイトル（別表記）	Reconsideration of Household Consumption Research in Consumer Behavior Research: Relationship between the Growth of Externalized Household Market and Wives’ Labor Participation
フルテキストURL	oer_054_2_001_013.pdf
著者	日高優一郎\|
抄録	This study looks back on early household consumption research in consumer behavior research and summarizes the challenges in considering the growth of externalized household market. This study shows that the effect of dualearner household to the externalization of household has not been necessarily identifi ed robustly, while the effects of income and life cycle have been identifi ed robustly. The study shows that it is necessary to control the effects of income and lifecycle to understand the effect of dual-earner household to the growth of externalized household market, and it is important to focus on the meanings given to time-saving products in consumption process.
出版物タイトル	岡山大学経済学会雑誌
発行日	2022-11-25
巻	54巻
号	2号
開始ページ	1
終了ページ	13
ISSN	2433-4146
言語	日本語
著作権者	Copyright © 2022 岡山大学経済学会
論文のバージョン	publisher

Is attention branch network effective in classifying dental implants from panoramic radiograph images by deep learning?

フルテキストURL	fulltext.pdf
著者	Sukegawa, Shintaro\| Yoshii, Kazumasa\| Hara, Takeshi\| Tanaka, Futa\| Yamashita, Katsusuke\| Kagaya, Tutaro\| Nakano, Keisuke\| Takabatake, Kiyofumi\| Kawai, Hotaka\| Nagatsuka, Hitoshi\| Furuki, Yoshihiko\|
発行日	2022-07-27
出版物タイトル	Plos One
巻	17巻
号	7号
出版者	Public Library Science
開始ページ	e0269016
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Sukegawa et al.
論文のバージョン	publisher
PubMed ID	35895591
DOI	10.1371/journal.pone.0269016
Web of Science KeyUT	000880183400018
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0269016

Graphene Oxide-based Endodontic Sealer: An in Vitro Study

JaLCDOI	10.18926/AMO/64122
フルテキストURL	76_6_715.pdf
著者	Mohammed Zahedul Islam Nizami\| Gorduysus, Melahat\| Shinoda-Ito, Yuki\| Yamamoto, Tadashi\| Nishina, Yuta\| Takashiba, Shogo\| Arias, Zulema\|
抄録	The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall.
キーワード	bioactive sealer graphene oxide mineral deposition antimicrobial activity radiopacity
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	715
終了ページ	721
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549774
Web of Science KeyUT	000905195100012

History of Transcatheter Arterial Chemoembolization Predicts the Efficacy of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients

JaLCDOI	10.18926/AMO/64120
フルテキストURL	76_6_695.pdf
著者	Onishi, Hideki\| Nouso, Kazuhiro\| Takaki, Akinobu\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Takeuchi, Yasuto\| Shiraha, Hidenori\| Okada, Hiroyuki\|
抄録	This study sought to identify factors that are predictive of a therapeutic response to hepatic arterial infusion chemotherapy (HAIC) by focusing on the number of prior transcatheter arterial chemoembolization (TACE) sessions. To determine the parameters predicting a good response to HAIC, we retrospectively analyzed 170 patients with hepatocellular carcinoma (HCC) who received HAIC regimens comprising low-dose cisplatin combined with 5-fluorouracil (LFP) or cisplatin (CDDP) for the first time. In both the LFP and CDDP regimens, the response rates were significantly lower in patients with three or more prior TACE sessions than in those with two or fewer prior TACE sessions (LFP 57% versus 28%; p=0.01, CDDP 27% versus 6%; p=0.01). Multivariable logistic regression analysis revealed that the number of prior TACE sessions (≥ 3) was significantly associated with non-responder status (odds ratio 4.17, 95% Confidence Interval (CI) 1.76-9.86) in addition to the HAIC regimen. Multivariable analysis using the Cox proportional hazards model revealed that a larger number of prior TACE sessions (≥ 3) was a significant risk factor for survival (hazard ratio 1.60, 95% CI 1.12-2.29) in addition to Child-Pugh class, serum alpha-fetoprotein concentration, and maximum diameter of HCC. HCC patients who receive fewer prior TACE sessions (≤ 2) were found to be better responders to HAIC.
キーワード	hepatic arterial infusion chemotherapy hepatocellular carcinoma refractory transcatheter arterial chemoembolization
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	695
終了ページ	703
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549772
Web of Science KeyUT	000905195100010