検索結果 47530 件
| JaLCDOI | 10.18926/AMO/63218 |
|---|---|
| フルテキストURL | 76_1_93.pdf |
| 著者 | Ishi, Yukitomo| Yamaguchi, Shigeru| Hatanaka, Kanako C.| Takakuwa, Emi| Motegi, Hiroaki| Honda, Taishi| Kobayashi, Hiroyuki| Terasaka, Shunsuke| Homma, Akihiro| Fujimura, Miki| Houkin, Kiyohiro| |
| 抄録 | A 66-year-old man underwent multimodal treatment for olfactory neuroblastoma (ONB). When he was 72 years old, a cystic intracranial lesion without accumulation on fluorine-18-fluorodeoxyglucose positron emission tomography was detected. Surgical resection was performed when the patient was 73 years old. The pathological examination revealed recurrence of ONB, and the patient underwent focal irradiation. At age 81, he presented with a second recurrence in the right occipital lobe with radiological and pathological findings similar to the prior recurrence. This case suggests that pathological confirmation should be considered in cases with atypical radiological findings following the treatment of ONB. |
| キーワード | cystic recurrence esthesioneuroblastoma fluorine-18-fluorodeoxyglucose positron emission tomography intracranial recurrence olfactory neuroblastoma |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 93 |
| 終了ページ | 98 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237005 |
| Web of Science KeyUT | 000762933000002 |
| JaLCDOI | 10.18926/AMO/63217 |
|---|---|
| フルテキストURL | 76_1_89.pdf |
| 著者 | Ryuko, Tsuyoshi| Yamamoto, Hiromasa| Sugimoto, Seiichiro| Suzawa, Ken| Miyoshi, Kentaroh| Otani, Shinji| Okazaki, Mikio| Yamane, Masaomi| Toyooka, Shinichi| |
| 抄録 | Congenital lobar emphysema (CLE) is defined as the hyperinflation of pulmonary lobes due to obstruction of the flow of air via a known or unknown etiology, which causes pressure symptoms in the adjacent organs. CLE is mainly diagnosed in the neonatal period, and very few adult cases have been reported. Here we report a 34-year-old male with muscular dystrophy who was diagnosed with CLE on examination. He underwent a right lower lobectomy via 3-portal completely video-assisted thoracoscopic surgery, and his symptoms improved. Thoracoscopic surgery helped preserve the respiratory muscles and led to the improvement of respiratory function in this patient. |
| キーワード | congenital lobar emphysema, adult, lobectomy, completely video-assisted thoracoscopic surgery, muscular dystrophy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 89 |
| 終了ページ | 92 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237004 |
| Web of Science KeyUT | 000762933000001 |
| JaLCDOI | 10.18926/AMO/63216 |
|---|---|
| フルテキストURL | 76_1_85.pdf |
| 著者 | Omi, Hirotsugu| Tomita, Takashi| Ichinohe, Masayuki| Harada, Yoshifumi| Sato, Hideki| Ito, Junji| |
| 抄録 | A 75-year-old woman underwent L4-L5 lateral interbody fusion for L4-5 foraminal stenosis with the use of percutaneous pedicle screws. On the day after the surgery, she was in shock. Emergency contrast-enhanced CT showed active extravasation from the 4th lumbar artery with a transverse process fracture. A radiologist performed a successful transarterial embolization, and the patient then began walking training on the 4th day post-surgery. Close attention should be paid to the insertion of a percutaneous pedicle screw, as it may cause a lumbar artery injury; in such a case, transarterial embolization is the preferred treatment. |
| キーワード | lumbar artery injury percutaneous pedicle screw transverse process fracture hematoma |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 85 |
| 終了ページ | 88 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237003 |
| Web of Science KeyUT | 000762803800003 |
| JaLCDOI | 10.18926/AMO/63215 |
|---|---|
| フルテキストURL | 76_1_79.pdf |
| 著者 | Tokumoto, Kana| Mino, Takuya| Kurosaki, Yoko| Izumi, Koji| Maekawa, Kenji| Nakano, Tomohito| Sejima, Junichi| Ueda, Akihiro| Kimura-Ono, Aya| Hyung Kim, Tae| Kuboki, Takuo| |
| 抄録 | We introduce a new digital workflow to fabricate a fixed partial denture (FPD) utilizing the three-dimensional surface morphology of provisional restoration (PR) and abutment teeth. Scanned images of the full maxilla with abutment teeth, full maxilla with PR, and PR alone were superimposed. The surfaces of the final FPD were designed based on the entire morphology of the PR and abutment teeth surfaces. The inner and outer surfaces converged at the margin lines of the abutment teeth. Fine modifications to the final FPD design were performed manually, and the final FPD was fabricated and successfully installed in the patient. |
| キーワード | prosthodontics computer-aided design digital dentistry fixed partial denture dental restoration |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 79 |
| 終了ページ | 84 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237002 |
| Web of Science KeyUT | 000762803800002 |
| JaLCDOI | 10.18926/AMO/63214 |
|---|---|
| フルテキストURL | 76_1_71.pdf |
| 著者 | Tanaka, Masato| Sonawane, Sumeet| Fujiwara, Yoshihiro| Uotani, Koji| Arataki, Shinya| Yamauchi, Taro| Ye, Youchen| Misawa, Haruo| |
| 抄録 | The surgical treatment of pediatric atlantoaxial subluxation (AAS) in Down syndrome (DS) remains technically challenging due to radiation exposure and complications such as vertebral artery injury and nonunion. The established treatment is fixation with a C1 lateral mass screw and C2 pedicle screw (modified Goel technique). However, this technique requires fluoroscopy for C1 screw insertion. To avoid exposing the operating team to radiation we present here a new C-arm free O-arm navigated surgical procedure for pediatric AAS in DS. A 5-year-old male DS patient had neck pain and unsteady gait. Radiograms showed AAS with an atlantodental interval of 10 mm, and irreducible subluxation on extension. CT scan showed Os odontoideum and AAS. MRI demonstrated spinal cord compression between the C1 posterior arch and odontoid process. We performed a C-arm free O-arm navigated modified Goel procedure with postoperative halo-vest immobilization. At oneyear follow-up, good neurological recovery and solid bone fusion were observed. The patient had no complications such as epidural hematoma, infection, or nerve or vessel injury. This novel procedure is a useful and safe technique that protects surgeons and staff from radiation risk. |
| キーワード | atlantoaxial fixation Down syndrome C-arm free O-arm navigation surgery modified Goel technique |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 71 |
| 終了ページ | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237001 |
| Web of Science KeyUT | 000762803800001 |
| JaLCDOI | 10.18926/AMO/63213 |
|---|---|
| フルテキストURL | 76_1_63.pdf |
| 著者 | Zhang, Bei| Pei, Zhixin| Wang, Hongxia| Wu, Huimin| Wang, Junjie| Bai, Junjun| Song, Qinglin| |
| 抄録 | We analyzed the treatment effects of chidamide and decitabine in combination with a HAG (homoharringtonine, cytarabine, G-CSF) priming regimen (CDHAG) in acute myeloid leukemia (AML) patients with TP53 mutation. Seven TP53 mutated AML patients were treated with CDHAG. The treatment effects were assessed using hemogram detection and bone marrow aspirate. The possible side effects were evaluated based on both hematological and non-hematological toxicity. Four of the seven patients were classified as having achieved complete remission after CDHAG treatment; one patient was considered to have achieved partial remission, and the remaining two patients were considered in non-remission. The overall response rate (ORR) to CDHAG was 71.4%. Regarding the side effects, the hematological toxicity level of the seven patients ranged from level III to level IV, and infections that occurred at lung, blood, and skin were recorded. Nausea, vomiting, liver injury, and kidney injury were also detected. However, all side effects were attenuated by proper management. The CDHAG regimen clearly improved the ORR (71.4%) of TP53-mutated AML patients, with no severe side effects. |
| キーワード | acute myeloid leukemia chidamide decitabine HAG TP53 mutation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 63 |
| 終了ページ | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237000 |
| Web of Science KeyUT | 000762812700009 |
| JaLCDOI | 10.18926/AMO/63212 |
|---|---|
| フルテキストURL | 76_1_57.pdf |
| 著者 | Iguchi, Toshihiro| Hiraki, Takao| Matsui, Yusuke| Toji, Tomohiro| Uka, Mayu| Tomita, Koji| Komaki, Toshiyuki| Umakoshi, Noriyuki| Mitsuhashi, Toshiharu| Kanazawa, Susumu| |
| 抄録 | To evaluate the volume and heat-sink effects of microwave ablation (MWA) in the ablation zone of the normal swine lung. MWA at 100 W was performed for 1, 2, and 3 min in 7, 5, and 5 lung zones, respectively. We assessed the histopathology in the ablation zones and other outcome measures: namely, length of the longest long and short axes, sphericity, ellipsoid area, and ellipsoid volume. The mean long- and short-axis diameters were 22.0 and 14.1 mm in the 1-min ablation zone, 27.6 and 20.2 mm in the 2-min ablation zone; and 29.2 and 21.2 mm in the 3-min ablation zone, respectively. All measures, except sphericity, were significantly less with 1-min ablation than with either 2- or 3-min ablation. There were no significant differences between the 2- and 3-min ablation zones, but all measures except sphericity were larger with 3-min ablation. Although there were no blood vessels that resulted in a heat-sink effect within the ablation zones, the presence of bronchi nearby in 5 lung ablation zones resulted in reduced ablation size. In high-power, short-duration MWA, the lung ablation volume was affected by ablation time. Some ablations showed that a heat-sink effect by a neighboring bronchus might occur. |
| キーワード | microwave ablation lung ablation zone heat-sink effect swine |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 57 |
| 終了ページ | 62 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35236999 |
| Web of Science KeyUT | 000762812700008 |
| フルテキストURL | fulltext20220222-2.pdf |
|---|---|
| 著者 | Kawashima, Takeshi| Yoshida, Masa-aki| Miyazawa, Hideyuki| Nakano, Hiroaki| Nakano, Natumi| Sakamoto, Tatsuya| Hamada, Mayuko| |
| キーワード | eDNA marine invertebrate Xenacoelomorpha Acoela Praesagittifera naikaiensis Placozoa Trichoplax adhaerens |
| 備考 | This fulltext is published by Zoological Society of Japan. To access the final published work, see https://doi.org/10.2108/zs210073 .| This full-text file will be available in Feb. 2023.| |
| 発行日 | 2022-01-28 |
| 出版物タイトル | Zoological Science |
| 巻 | 39巻 |
| 号 | 1号 |
| 出版者 | Zoological Society of Japan |
| 開始ページ | 157 |
| 終了ページ | 165 |
| ISSN | 0289-0003 |
| NCID | AA10545874 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Zoological Society of Japan |
| 論文のバージョン | publisher |
| PubMed ID | 35107003 |
| DOI | 10.2108/zs210073 |
| Web of Science KeyUT | 000752098100015 |
| 関連URL | isVersionOf https://doi.org/10.2108/zs210073 |
| フルテキストURL | fulltext20220222-1.pdf SI20220222-1.pdf |
|---|---|
| 著者 | Okamoto, Ryuichi| Koga, Kenichiro| |
| 備考 | This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry B, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcb.1c08050 .| |
| 発行日 | 2021-11-10 |
| 出版物タイトル | The Journal of Physical Chemistry B |
| 巻 | 125巻 |
| 号 | 46号 |
| 出版者 | American Chemical Society (ACS) |
| 開始ページ | 12820 |
| 終了ページ | 12831 |
| ISSN | 1520-6106 |
| NCID | AA11114073 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 American Chemical Society |
| 論文のバージョン | author |
| PubMed ID | 34756051 |
| DOI | 10.1021/acs.jpcb.1c08050 |
| Web of Science KeyUT | 000750898200015 |
| 関連URL | isVersionOf https://doi.org/10.1021/acs.jpcb.1c08050 |
| JaLCDOI | 10.18926/AMO/63209 |
|---|---|
| フルテキストURL | 76_1_51.pdf |
| 著者 | Eto, Eriko| Tani, Kazumasa| Maki, Jota| Hayata, Kei| Masuyama, Hisashi| |
| 抄録 | Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder that is associated with high insulin resistance and obesity. However, ~70% of women with PCOS in Japan are non-obese. We retrospectively analyzed the cases of 163 Japanese women with PCOS who visited our Ob/Gyn department in 2006-2018 to determine which has a greater effect on insulin resistance: PCOS or obesity. We reviewed the women’s medical records and calculated their insulin resistance and insulin secretion. The women’s mean age and pre-pregnancy body mass index (BMI) were 30±5.8 years and 24.8±5.6 kg/m2, respectively; their mean ± SD fasting plasma glucose, 94.1±13.7 mg/dL; HOMA-IR, 2.1±2.0; QUICKI, 0.4±0.0; and HOMA-β, 108.9±88.0%. Sixtyeight women were pregnant, and 37% (n=25) were obese (BMI ≥ 25 kg/m2). Obesity had a greater effect on insulin resistance: fasting plasma glucose F(1, 53)=6.134, p<0.05; fasting insulin F(1, 53)=31.606, p<0.01; HOMA-IR F(1, 53)=31.670, p<0.01; QUICKI F(1, 53)=16.156, p<0.01. There was no significant difference in values other than QUICKI and testosterone between the women with and without PCOS. Obesity thus had a greater effect on increased insulin resistance in pregnant women with PCOS. Further studies of the insulin resistance of non-obese women with PCOS is needed, as non-obese women with PCOS are common in Asia. |
| キーワード | polycystic ovary syndrome insulin resistance obesity pregnancy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 51 |
| 終了ページ | 56 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35236998 |
| Web of Science KeyUT | 000762812700007 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsueda, Katsunori| Kanzaki, Hiromitsu| Takenaka, Ryuta| Nakagawa, Masahiro| Matsueda, Kazuhiro| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Toji, Tomohiro| Tanaka, Takehiro| Yagi, Takahito| Fujiwara, Toshiyoshi| Okada, Hiroyuki| |
| 発行日 | 2021-08-27 |
| 出版物タイトル | PLOS ONE |
| 巻 | 16巻 |
| 号 | 8号 |
| 出版者 | Public Library Science |
| 開始ページ | e0256797 |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 Matsueda et al. |
| 論文のバージョン | publisher |
| PubMed ID | 34449813 |
| NAID | 120007193739 |
| DOI | 10.1371/journal.pone.0256797 |
| Web of Science KeyUT | 000752313300044 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0256797 |
| JaLCDOI | 10.18926/AMO/63207 |
|---|---|
| フルテキストURL | 76_1_41.pdf |
| 著者 | Miyahara, Hiroyuki| Miyai, Takayuki| Aya, Kunihiko| Tsukahara, Hirokazu| |
| 抄録 | High-dose steroids are required for the treatment of minimal change nephrotic syndrome (MCNS), especially for episodes of recurrence. Predicting and avoiding recurrence can help reduce the steroid dose, but prediction is currently difficult. We herein examined whether changes in laboratory data, especially the urinary protein- to-creatinine ratio (UTP/UCr), can predict clinical recurrence. We also assessed differences in clinical features between children and young adults. We included 36 patients with MCNS; for each case, we retrospectively studied laboratory data during stable remission and pre-recurrence, with the “stable” period defined as all but the 6 weeks before recurrence, and pre-recurrence defined as the 4±2 weeks before recurrence. UTP/UCr, serum albumin, etc. were measured every 5 years during stable periods. We divided patients into cohorts by age at recurrence, < 15 years and ≥ 15 years, and compared stable and pre-recurrence values for the two groups. UTP/UCr values during stable periods tended to be higher in younger patients. UTP/UCr and serum albumin showed statistically significant changes during pre-recurrence periods, but only in those aged ≥ 15 years. Thus, clinical features of recurrence differed depending on age. Signs of recurrence can be confirmed via UTP/UCr or serum albumin several weeks before recurrence in patients ≥ 15 years. |
| キーワード | minimal change nephrotic syndrome recurrence urinary protein to creatinine ratio |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 41 |
| 終了ページ | 49 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35236997 |
| Web of Science KeyUT | 000762812700006 |
| JaLCDOI | 10.18926/AMO/63206 |
|---|---|
| フルテキストURL | 76_1_33.pdf |
| 著者 | Zhou, Jia-Yi| Hou, Hai-Tao| Wang, Shi-Fu| Yang, Qin| He, Guo-Wei| |
| 抄録 | Trace elements selenium (Se) and cobalt (Co) are essential in the human body, and a correlation between Se and cardiac surgery has been suggested. We investigated the plasma concentrations of Se and Co during and after coronary artery bypass grafting (CABG) surgery under cardiopulmonary bypass (CPB). From December 2019 to January 2020, preoperative plasma samples from isolated first-time CABG patients (n=20; 10 males, 10 females) were prospectively collected post-anesthesia and before CPB (T1), 45 min after CPB started (T2), 90 min after CPB started (T3), and postoperative days 1 (T4), and day 4 (T5). The plasma concentrations of Se and Co were measured. The Se concentration was significantly decreased at T2 (105.24±4.08 vs. 68.56±2.42 μg/L, p<0.001) and T3 (105.24±4.08 vs. 80.41±3.40 μg/L, p<0.001). The Co concentration was significantly decreased at T4 (0.35±0.19 vs. 0.26±0.13 μg/L, p<0.01) and T5 (0.35±0.19 vs. 0.23±0.11 μg/L, p<0.001). Five patients developed atrial fibrillation (AF); there was no other operative mortality or major morbidity. This is the first report of alterations of plasma Se and Co concentrations during and after CABG surgery. Our results may indicate that Se supplementation before or during CABG and Co supplementation after CABG may become necessary for patients undergoing CABG. |
| キーワード | trace element CABG cardiopulmonary bypass selenium cobalt |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 33 |
| 終了ページ | 39 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35236996 |
| Web of Science KeyUT | 000762812700005 |
| JaLCDOI | 10.18926/AMO/63205 |
|---|---|
| フルテキストURL | 76_1_25.pdf |
| 著者 | Sugimoto, Kohei| Kuroda, Masahiro| Yoshimura, Yuuki| Hamada, Kentaro| Khasawneh, Abdullah| Barham, Majd| Tekiki, Nouha| Konishi, Kohei| Ishizaka, Hinata| Shimizu, Yudai| Nakamitsu, Yuki| Al-Hammad, Wlla E. | Kamizaki, Ryo| Kanazawa, Susumu| Asaumi, Junichi| |
| 抄録 | The apparent diffusion coefficient subtraction method (ASM) was developed as a new restricted diffusionweighted imaging technique for magnetic resonance imaging (MRI). The usefulness of the ASM has been established by in vitro basic research using a bio-phantom, and clinical research on the application of the ASM for the human body is needed. Herein, we developed a short-time sequence for ASM imaging of the heads of healthy volunteers (n=2), and we investigated the similarity between the obtained ASM images and diffusion kurtosis (DK) images to determine the utility of the ASM for clinical uses. This study appears to be the first to report ASM images of the human head. We observed that the short-time sequence for the ASM imaging of the head can be scanned in approx. 3 min at 1.5T MRI. The noise reduction effect of median filter processing was confirmed on the ASM images scanned by this sequence. The obtained ASM images showed a weak correlation with the DK images, indicating that the ASM images are restricted diffusion-weighted images. The new shorttime imaging sequence could thus be used in clinical studies applying the ASM. |
| キーワード | apparent diffusion coefficient apparent diffusion coefficient subtraction method diffusion kurtosis imaging restricted diffusion short-time imaging |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 25 |
| 終了ページ | 32 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35236995 |
| Web of Science KeyUT | 000762812700004 |
| JaLCDOI | 10.18926/AMO/63204 |
|---|---|
| フルテキストURL | 76_1_17.pdf |
| 著者 | Fujishita, Keigo| Yasuhisa, Sando| Oka, Satoshi| Fujisawa, Yuka| Machida, Takuya| Imai, Toshi| |
| 抄録 | R-CHOP therapy is generally performed every 3 weeks. We investigated the effects of extending the interval of R-CHOP therapy for > 1 week on the prognoses of patients with non-indolent non-Hodgkin’s B-cell lymphoma. Among the 338 patients with non-indolent non-Hodgkin’s B-cell lymphoma who received initial chemotherapy at our institution, we focused on 178 patients who received R-CHOP therapy and analyzed the outcomes of the patients stratified by the treatment intervals. The estimated 3-year overall survival (OS) for the entire population was 82.1%. Patients treated at intervals of ≥ 4 weeks were significantly older, and they had significantly longer follow-up periods and lower relative dose intensity. But the estimated 3-year OS was comparable to those treated at <4 weeks (83.3% vs. 80.5% p=0.947). In a multivariate analysis, age and the dose of anti-cancer agents had significant impacts on OS, but there was no significant relationship regarding the treatment intervals. Propensity score matching confirmed the same result. R-CHOP therapy every around 4 weeks could achieve relatively good survival in some selected patients with non-indolent non-Hodgkin’s B-cell lymphoma. |
| キーワード | R-CHOP therapy relative dose intensity non-Hodgkin’s lymphoma |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 17 |
| 終了ページ | 24 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35236994 |
| Web of Science KeyUT | 000762812700003 |
| JaLCDOI | 10.18926/AMO/63203 |
|---|---|
| フルテキストURL | 76_1_7.pdf |
| 著者 | Takami, Masao| Yamamoto, Koichiro| Hanayama, Yoshihisa| Nakano, Yasuhiro| Hasegawa, Kou| Obika, Mikako| Hagiya, Hideharu| Furukawa, Masanori| Otsuka, Fumio| |
| 抄録 | Subclinical hypothyroidism (SCH) is diagnosed when serum thyrotropin (TSH) is elevated despite a normal thyroxine level and is known to increase the risk of metabolic disorders. This study was conducted to identify potential laboratory markers suspicious for latent SCH. We retrospectively reviewed 958 outpatients in whom thyroid functions had been examined. Eighty-five (9.1%) of the 939 analyzed subjects had SCH (73% females). In the SCH group, median serum TSH and FT4 levels were 5.04 μU/ml and 1.19 ng/dl, respectively, and auto-thyroid antibodies were detected in 53.8% of patients. SCH group patients were significantly older than patients in the euthyroid group, while there was no intergroup difference in BMI. However, 56.5% of the SCH patients were asymptomatic. In the SCH group, serum aspartate aminotransferase and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher, and the estimated glomerular filtration rate (eGFR) was significantly lower than in the euthyroid group. Among patients less than 65 years of age, SCH patients tended to have lower eGFR and higher LDL-C than euthyroid patients. Age-dependent reductions of red blood cells and serum albumin were more prominent in the SCH than the euthyroid group. Biochemical changes with aging are useful as potential clues for suspecting latent SCH. |
| キーワード | aging renal function cholesterol subclinical hypothyroidism thyroid function |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 7 |
| 終了ページ | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35236993 |
| Web of Science KeyUT | 000762812700002 |
| JaLCDOI | 10.18926/AMO/63202 |
|---|---|
| フルテキストURL | 76_1_1.pdf |
| 著者 | Takao, Tomoka| Yamada, Daisuke| Takarada, Takeshi| |
| 抄録 | Optogenetics, a technology to manipulate biological phenomena thorough light, has attracted much attention in neuroscience. Recently, the Magnet System, a photo-inducible protein dimerization system which can control the intracellular behavior of various biomolecules with high accuracy using light was developed. Furthermore, photoactivation systems for controlling biological phenomena are being developed by combining this technique with genome-editing technology (CRISPR/Cas9 System) or DNA recombination technology (Cre-loxP system). Herein, we review the history of optogenetics and the latest Magnet System technology and introduce our recently developed photoactivatable Cre knock-in mice with temporal-, spatial-, and cell-specific accuracy. |
| キーワード | optogenetics Cre recombinase |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 5 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35236992 |
| Web of Science KeyUT | 000762812700001 |
| フルテキストURL | fulltext20220216-4.pdf |
|---|---|
| 著者 | Nomura, Emi| Kawahara, Yuko| Omote, Yoshio| Takahashi, Yoshiaki| Matsumoto, Namiko| Ikegami, Ken| Takemoto, Mami| Hishikawa, Nozomi| Nakano, Yumiko| Yunoki, Taijun| Morihara, Ryuta| Uemura, Masahiro| Abe, Koji| Yamashita, Toru| |
| キーワード | ATP-binding cassette subfamily C member 6 (ABCC6) neurovascular diseases pseudoxanthoma elasticum (PXE) |
| 備考 | This is the peer reviewed version of the following article: [Nomura, E, Kawahara, Y, Omote, Y, et al. A case of a heterozygous ABCC6 mutation showing recurrent ischemic strokes and intracranial hemorrhages. Neurol Clin Neurosci. 2022; 00: 1– 4. doi:10.1111/ncn3.12575], which has been published in final form at https://doi.org/10.1111/ncn3.12575. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| 発行日 | 2022-2-4 |
| 出版物タイトル | Neurology and Clinical Neuroscience |
| 巻 | 10巻 |
| 出版者 | Wiley |
| 開始ページ | 98 |
| 終了ページ | 101 |
| ISSN | 2049-4173 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1111/ncn3.12575 |
| Web of Science KeyUT | 000750987400001 |
| 関連URL | isVerisonOf https://doi.org/10.1111/ncn3.12575 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nagasaki, Joji| Inozume, Takashi| Sax, Nicolas| Ariyasu, Ryo| Ishikawa, Masakazu| Yamashita, Kazuo| Kawazu, Masahito| Ueno, Toshihide| Irie, Takuma| Tanji, Etsuko| Morinaga, Takao| Honobe, Akiko| Ohnuma, Takehiro| Yoshino, Mitsuru| Iwata, Takekazu| Kawase, Katsushige| Sasaki, Keita| Hanazawa, Toyoyuki| Kochin, Vitaly| Kawamura, Tatsuyoshi| Matsue, Hiroyuki| Hino, Masayuki| Mano, Hiroyuki| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Togashi, Yosuke| |
| 発行日 | 2022-02-01 |
| 出版物タイトル | Cell Reports |
| 巻 | 38巻 |
| 号 | 5号 |
| 出版者 | Cell Press |
| 開始ページ | 110331 |
| ISSN | 2211-1247 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 35108529 |
| NAID | 120007192058 |
| DOI | 10.1016/j.celrep.2022.110331 |
| Web of Science KeyUT | 000750983700001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.celrep.2022.110331 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Higo, Hisao| Ohashi, Kadoaki| Tomida, Shuta| Okawa, Sachi| Yamamoto, Hiromasa| Sugimoto, Seiichiro| Senoo, Satoru| Makimoto, Go| Ninomiya, Kiichiro| Nakasuka, Takamasa| Nishii, Kazuya| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Toyooka, Shinichi| Kiura, Katsuyuki| |
| キーワード | Idiopathic pulmonary fibrosis RNA sequencing Molecular therapeutic target Personalized therapy |
| 発行日 | 2022-02-07 |
| 出版物タイトル | Respiratory Research |
| 巻 | 23巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 20 |
| ISSN | 1465-993X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 35130915 |
| DOI | 10.1186/s12931-022-01940-y |
| Web of Science KeyUT | 000752386100002 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12931-022-01940-y |