検索結果 - 岡山大学学術成果リポジトリ

The Impact of Tofogliflozin on Physiological and Hormonal Function, Serum Electrolytes, and Cardiac Diastolic Function in Elderly Japanese Patients with Type 2 Diabetes Mellitus

JaLCDOI	10.18926/AMO/64121
フルテキストURL	76_6_705.pdf
著者	Higashikawa, Toshihiro\| Ito, Tomohiko\| Mizuno, Takurou\| Ishigami, Keiichiro\| Kuroki, Kengo\| Maekawa, Naoto\| Usuda, Daisuke\| Izumida, Toshihide\| Yamada, Shinya\| Sangen, Ryusho\| Hamada, Kazu\| Kiyosawa, Jun\| Saito, Atsushi\| Iguchi, Masaharu\| Kasamaki, Yuji\| Nakahashi, Takeshi\| Fukuda, Akihiro\| Saito, Hitoshi\| Kanda, Tsugiyasu\| Okuro, Masashi\|
抄録	The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function.
キーワード	tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	705
終了ページ	713
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549773
Web of Science KeyUT	000905195100011

History of Transcatheter Arterial Chemoembolization Predicts the Efficacy of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients

JaLCDOI	10.18926/AMO/64120
フルテキストURL	76_6_695.pdf
著者	Onishi, Hideki\| Nouso, Kazuhiro\| Takaki, Akinobu\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Takeuchi, Yasuto\| Shiraha, Hidenori\| Okada, Hiroyuki\|
抄録	This study sought to identify factors that are predictive of a therapeutic response to hepatic arterial infusion chemotherapy (HAIC) by focusing on the number of prior transcatheter arterial chemoembolization (TACE) sessions. To determine the parameters predicting a good response to HAIC, we retrospectively analyzed 170 patients with hepatocellular carcinoma (HCC) who received HAIC regimens comprising low-dose cisplatin combined with 5-fluorouracil (LFP) or cisplatin (CDDP) for the first time. In both the LFP and CDDP regimens, the response rates were significantly lower in patients with three or more prior TACE sessions than in those with two or fewer prior TACE sessions (LFP 57% versus 28%; p=0.01, CDDP 27% versus 6%; p=0.01). Multivariable logistic regression analysis revealed that the number of prior TACE sessions (≥ 3) was significantly associated with non-responder status (odds ratio 4.17, 95% Confidence Interval (CI) 1.76-9.86) in addition to the HAIC regimen. Multivariable analysis using the Cox proportional hazards model revealed that a larger number of prior TACE sessions (≥ 3) was a significant risk factor for survival (hazard ratio 1.60, 95% CI 1.12-2.29) in addition to Child-Pugh class, serum alpha-fetoprotein concentration, and maximum diameter of HCC. HCC patients who receive fewer prior TACE sessions (≤ 2) were found to be better responders to HAIC.
キーワード	hepatic arterial infusion chemotherapy hepatocellular carcinoma refractory transcatheter arterial chemoembolization
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	695
終了ページ	703
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549772
Web of Science KeyUT	000905195100010

An Evaluation of the Efficacy of Compression Therapy Using Sleeves and Stockings to Prevent Docetaxel-induced Peripheral Neuropathy in Breast Cancer Patients

JaLCDOI	10.18926/AMO/64119
フルテキストURL	76_6_689.pdf
著者	Yamanouchi, Kosho\| Kuba, Sayaka\| Matsumoto, Megumi\| Yano, Hiroshi\| Morita, Michi\| Sakimura, Chika\| Otsubo, Ryota\| Hidaka, Masaaki\| Nagayasu, Takeshi\| Eguchi, Susumu\|
抄録	Taxanes are key drugs for patients with breast cancer. A major adverse effect of taxanes is peripheral neuropathy (PN). To investigate the ability of compression therapy using sleeves and stockings to prevent PN due to the taxane docetaxel, we conducted a single-center historical control trial. Patients receiving docetaxel at 75 mg/m2 every 3 weeks for 4 cycles as first-line chemotherapy for breast cancer were eligible. PN was evaluated using the common terminology criteria for adverse events version 4.0. The primary endpoint was the incidence of allgrade PN until 3 weeks after the fourth docetaxel administration. We evaluated 26 patients in the intervention group and compared their data to those collected retrospectively from 52 patients treated with docetaxel without compression. Neither the incidence of all-grade PN until 3 weeks after the fourth docetaxel administration (63.5% in the control group vs. 76.9% in the intervention group, p=0.31) nor that of PN grade ≥ 2 (13.5% vs. 15.4%, p=0.99) differed between the groups. In this study, the efficacy of compression therapy using sleeves and stockings to prevent PN induced by docetaxel was not demonstrated. Further clinical studies including medications or intervention are needed to reduce the incidence and severity of PN induced by chemotherapy.
キーワード	breast cancer docetaxel neuropathy compression
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	689
終了ページ	694
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549771
Web of Science KeyUT	000905195100009

Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma

フルテキストURL	K0006694_abstract_review.pdf K0006694_fulltext.pdf K0006694_summary.pdf
著者	小西大輔\|
発行日	2022-09-22
資料タイプ	学位論文
学位授与番号	甲第6694号
学位授与年月日	2022-09-22
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© The Author(s) 2022

Idiopathic Pneumonia Syndrome Refractory to Ruxolitinib after Post-Transplant Cyclophosphamide-based Haploidentical Hematopoietic Stem Cell Transplantation: Lung Pathological Findings from an Autopsy Case

JaLCDOI	10.18926/AMO/64044
フルテキストURL	76_5_609.pdf
著者	Matsumoto, Ken\| Fujishita, Keigo\| Matsuda, Masayuki\| Oka, Satoshi\| Fujisawa, Yuka\| Imai, Toshi\| Machida, Takuya\|
抄録	A 69-year-old Japanese man with acute leukemia received post-transplant cyclophosphamide-based haploidentical stem cell transplantation (PTCY-haplo-SCT) but was readmitted with dyspnea and ground-glass-opacities of the lungs. Bronchoscopy showed inflammatory changes with no signs of infection. He received steroids but required intubation as his condition deteriorated. In addition to antithymocyte globulin and cyclophosphamide, we administered ruxolitinib but failed to save him. Autopsy findings revealed fibrotic nonspecific interstitial pneumonia (NSIP) without evidence of organizing pneumonia or infection. Thus, we diagnosed idiopathic pneumonia syndrome (IPS). As far as our knowledge, this is the first case of IPS with NSIP histology after PTCY-haplo-SCT.
キーワード	idiopathic pneumonia syndrome ruxolitinib post-transplant cyclophosphamide-based haploidentical stem cell transplantation nonspecific interstitial pneumonia
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	609
終了ページ	615
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352810
Web of Science KeyUT	000884907100016

A Simple and Descriptive Assessment of Morphology Based on the Horizontal Plane of the Pediatric Head and Creation of a Normative Database in Japanese Children 6 Years Old and under: Horizontal Vector Analysis

JaLCDOI	10.18926/AMO/64038
フルテキストURL	76_5_565.pdf
著者	Komagoe, Sho\| Senoo, Takaya\| Takao, Soshi\| Shiraishi, Yoshinori\| Matsumoto, Hiroshi\| Kimata, Yoshihiro\|
抄録	We herein introduce horizontal vector analysis, a simple method for assessing cranial morphology based on measurement of the head’s horizontal plane, and use this method to establish normal cranial morphology in Japanese children Computed tomography scans taken in 2010-2019 in healthy Japanese children aged ≤ 6 years. The two measurement planes were parallel to the orbitomeatal plane: namely, a plane passing through the dorsum sellae (DS) and the plane superior to that with the maximal area (Max plane). A protractor was used to circumferentially measure the lengths from the central point to the outer surface of the skull. A total of 487 images were extracted. The distances between the DS and Max planes were consistently almost 30 mm for each age group, so we fixed the Max plane as the plane 30 mm superior to the DS plane. Finally, we established datasets of normal values for each age group and sex. Using these norms, perioperative evaluation of various cranial deformities could be performed more easily and circumstantially.
キーワード	craniofacial surgery craniosynostoses horizontal plane Japanese children reference values
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	565
終了ページ	575
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352804
Web of Science KeyUT	000884907100010

Current Insights into Mesenchymal Signatures in Glioblastoma

JaLCDOI	10.18926/AMO/64024
フルテキストURL	76_5_489.pdf
著者	Matsumoto, Yuji\| Ichikawa, Tomotsugu\| Kurozumi, Kazuhiko\| Date, Isao\|
抄録	Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives.
キーワード	glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	489
終了ページ	502
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352795
Web of Science KeyUT	000884907100001

Bilateral verses bilateral with tri-segmental endoscopic drainage using metal stents for high-grade malignant hilar biliary obstructions: A multicenter, randomized controlled trial: BRAVE study (BRAVE study)

フルテキストURL	fulltext.pdf
著者	Matsumoto, Kazuyuki\| Mitsuhashi, Toshiharu\| Kawamoto, Hirofumi\| Ishida, Etsuji\| Fujii, Masakuni\| Akimoto, Yutaka\| Seki, Hiroyuki\| Ishihara, Yuki\| Ogawa, Taiji\| Yamazaki, Tatsuhiro\| Fujii, Yuki\| Kato, Hironari\|
キーワード	bilateral drainage bile duct obstruction endoscopic biliary drainage neoplasms self-expandable metallic stents
発行日	2022-10-07
出版物タイトル	Medicine
巻	101巻
号	40号
出版者	Lippincott Williams & Wilkins
開始ページ	e30857
ISSN	0025-7974
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 the Author(s).
論文のバージョン	publisher
PubMed ID	36221399
DOI	10.1097/MD.0000000000030857
Web of Science KeyUT	000865518700110
関連URL	isVersionOf https://doi.org/10.1097/MD.0000000000030857

Cnm of Streptococcus mutans is important for cell surface structure and membrane permeability

フルテキストURL	fulltext.pdf
著者	Naka, Shuhei\| Matsuoka, Daiki\| Goto, Kana\| Misaki, Taro\| Nagasawa, Yasuyuki\| Ito, Seigo\| Nomura, Ryota\| Nakano, Kazuhiko\| Matsumoto-Nakano, Michiyo\|
キーワード	Streptococcus mutans collagen-binding protein membrane permeability cell structure RNA-seq
発行日	2022-09-13
出版物タイトル	Frontiers In Cellular And Infection Microbiology
巻	12巻
出版者	Frontiers Media S.A.
開始ページ	994014
ISSN	2235-2988
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Naka, Matsuoka, Goto, Misaki, Nagasawa, Ito, Nomura, Nakano and Matsumoto-Nakano.
論文のバージョン	publisher
PubMed ID	36176579
DOI	10.3389/fcimb.2022.994014
Web of Science KeyUT	000861324100001
関連URL	isVersionOf https://doi.org/10.3389/fcimb.2022.994014

Anxiolytic-like effects of hochuekkito in lipopolysaccharide-treated mice involve interleukin-6 inhibition

フルテキストURL	fulltext.pdf
著者	Ushio, Soichiro\| Wada, Yudai\| Nakamura, Mizuki\| Matsumoto, Daiki\| Hoshika, Kota\| Shiromizu, Shoya\| Iwata, Naohiro\| Esumi, Satoru\| Kajizono, Makoto\| Kitamura, Yoshihisa\| Sendo, Toshiaki\|
キーワード	anxiolytic inflammation immunomodulation macrophages Kampo medicine
発行日	2022-08-12
出版物タイトル	Frontiers In Pharmacology
巻	13巻
出版者	Frontiers Media S.A.
開始ページ	890048
ISSN	1663-9812
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Ushio, Wada, Nakamura, Matsumoto, Hoshika, Shiromizu, Iwata, Esumi, Kajizono, Kitamura and Sendo.
論文のバージョン	publisher
PubMed ID	36034871
DOI	10.3389/fphar.2022.890048
Web of Science KeyUT	000860773600001
関連URL	isVersionOf https://doi.org/10.3389/fphar.2022.890048

Efficacy of intraductal placement of non‐flared fully‐covered metal stent for refractory perihilar benign biliary strictures: A multicenter prospective study with long‐term observation

フルテキストURL	fulltext20221004-1.pdf Figure_1_20221004-1.jpg Figure_2A_20221004-1.jpg Figure_2B_20221004-1.jpg Figure_2C_20221004-1.jpg Figure_2D_20221004-1.jpg Figure_3_20221004-1.jpg Figure_4_20221004-1.jpg
著者	Matsumoto, Kazuyuki\| Kato, Hironari\| Fujii, Masakuni\| Ueki, Toru\| Saragai, Yosuke\| Tsugeno, Hirofumi\| Mannami, Tomohiko\| Okada, Hiroyuki\|
キーワード	benign biliary stricture fully-covered self-expandable metal stent intraductal placement refractory biliary stricture
備考	This is the peer reviewed version of the following article: [Matsumoto, K, Kato, H, Fujii, M, Ueki, T, Saragai, Y, Tsugeno, H, Efficacy of intraductal placement of nonflared fully-covered metal stent for refractory perihilar benign biliary strictures: A multicenter prospective study with long-term observation. J Hepatobiliary Pancreat Sci. 2022; 29: 1300– 1307. https://doi.org/10.1002/jhbp.1188], which has been published in final form at [https://doi.org/10.1002/jhbp.1188]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\| This fulltext is available in June 2023.\|
発行日	2022-06-03
出版物タイトル	Journal of Hepato-Biliary-Pancreatic Sciences
巻	29巻
号	12号
出版者	Wiley
開始ページ	1300
終了ページ	1307
ISSN	1868-6974
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Japanese Society of Hepato-Biliary-Pancreatic Surgery.
論文のバージョン	author
PubMed ID	35657019
DOI	10.1002/jhbp.1188
Web of Science KeyUT	000814050800001
関連URL	isVersionOf https://doi.org/10.1002/jhbp.1188

A case of endoscopic retrograde cholangiopancreatography-related main pancreatic duct perforation salvaged by endoscopic ultrasonography-guided pancreatic duct drainage

フルテキストURL	fulltext20220922-2.pdf Table1_20220922-2.pdf Table2_20220922-2.pdf figure20220922-2.pdf
著者	Sato, Ryosuke\| Matsumoto, Kazuyuki\| Matsumi, Akihiro\| Morimoto, Kosaku\| Terasawa, Hiroyuki\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Tsutsumi, Koichiro\| Horiguchi, Shigeru\| Kato, Hironari\|
キーワード	EUS-guided pancreatic duct drainage Pancreatic duct perforation ERCP-related perforation
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12328-022-01699-1 This fulltext is available in Sep. 2023.\|
発行日	2022-09-12
出版物タイトル	Clinical Journal of Gastroenterology
巻	15巻
号	6号
出版者	Springer Science and Business Media LLC
開始ページ	1179
終了ページ	1184
ISSN	1865-7257
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Japanese Society of Gastroenterology 2022
論文のバージョン	author
PubMed ID	36094734
DOI	10.1007/s12328-022-01699-1
Web of Science KeyUT	000852906700001
関連URL	isVersionOf https://doi.org/10.1007/s12328-022-01699-1

Social Capital and Post-traumatic Stress Disorder among Heavy Rainfall and Flood Victims in Japan

JaLCDOI	10.18926/AMO/63903
フルテキストURL	76_4_439.pdf
著者	Miyaji, Chikara\| Takao, Soshi\| Noguchi, Masayuki\| Okazaki, Tsubasa\| Sato, Shunsuke\| Yorifuji, Takashi\|
抄録	This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged≥18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex.
キーワード	social capital post-traumatic stress disorder disaster flooding
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	439
終了ページ	446
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123159
Web of Science KeyUT	000882167300010

5-Nitro-2-(3-phenylpropylamino) Benzoic Acid Inhibits the Proliferation and Migration of Lens Epithelial Cells by Blocking CaMKII Signaling

JaLCDOI	10.18926/AMO/63896
フルテキストURL	76_4_415.pdf
著者	Kang, Haijun\| Huang, Dongmei\| Kang, Gangjin\| Yang, Xu\| Li, Heng\| Liu, Siyuan\| Gou, Wenjun\| Liu, Linglin\| Qiu, Yuyan\|
抄録	Posterior capsule opacification (PCO) is a post-surgery complication of cataract surgery, and lens epithelial cells (LECs) are involved in its development. A suppressive effect on LECs is exerted by the non specific chloride channel inhibitor 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) exerts. Herein, the growth and migration inhibitory effects of NPPB on LECs were assessed, and the mechanism underlying the effects were investigated by focusing on Ca2+/CaMKII signaling. LECs were treated with different concentrations of NPPB, and the changes in cell viability, cell-cycle distribution, anchorage-dependent growth, migration, Ca2+ level, and CaMKII expression were evaluated. NPPB inhibited LECs’ proliferation and induced G1 cell-cycle arrest in the cells. Regarding LECs’ mobility, NPPB suppressed the cells’ anchorage-dependent growth ability and inhibited their migration. Changes in cell phenotypes were associated with an increased intracellular Ca2+ level and down-regulation of CaMKII. Together these results confirmed the inhibitory effect of NPPB on the proliferation and migration of LECs, and the effect was shown to be associated with the induced level of Ca2+ and the inhibition of CaMKII signaling transduction.
キーワード	5-nitro-2-(3-phenylpropylamino) benzoic acid CaMKII lens epithelial cell migration proliferation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	415
終了ページ	421
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123156
Web of Science KeyUT	000882167300007

Postoperative Urinary Retention in Japanese Elderly Males with a Femoral Neck or Trochanteric Fracture

JaLCDOI	10.18926/AMO/63895
フルテキストURL	76_4_409.pdf
著者	Higashikawa, Toshihiro\| Shigemoto, Kenji\| Goshima, Kenichi\| Iwai, Shintarou\| Moriyama, Manabu\| Usuda, Daisuke\| Hangyou, Masahiro\| Inujima, Hiromi\| Nozaki, Kakeru\| Yamaguchi, Miyako\| Usuda, Kimiko\| Nakahashi, Takeshi\| Matsumoto, Tadami\| Takashima, Shigeki\| Kanda, Tsugiyasu\| Horii, Takeshi\| Okuro, Masashi\| Sawaguchi, Takeshi\|
抄録	We assessed risk factors for postoperative urinary retention (UR) in elderly males with femoral bone fractures: 169 Japanese males (mean age 81.95 ± 1.19 years) who had undergone hip surgery at a municipal hospital (Toyama, Japan). A multiple logistic regression analysis was used to test possible risk factors for UR: age, body mass index, serum albumin, cognitive impairment, activities of daily living (ADL), and history of diabetes mellitus (DM). UR occurred in 24 (14.2%) of the 169 patients. A multivariate logistic regression analysis with age adjustment showed that ADL (odds ratio [OR] 3.88; 95% confidence interval [CI]: 1.2-12.5, p=0.023) was significantly associated with the development of UR, and a history of DM showed marginal significance for UR occurrence (OR 0.36, 95%CI: 0.11-10, p=0.064). These results suggests that ADL is a risk factor for UR development in elderly males who have undergone surgery for femoral neck or trochanter fractures.
キーワード	elderly femoral bone fracture albumin urinary retention activities of daily living
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	409
終了ページ	414
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123155
Web of Science KeyUT	000882167300006

Pectoralis Major and Serratus Anterior Muscle Flap for Diaphragmatic Reconstruction

フルテキストURL	ANNALS-S-21-02810.pdf
著者	Watanabe, Toshiyuki\| Matsumoto, Hiroshi\| Yoshida, Ryuichi\| Yasui, Kazuya\| Yagi, Takahito\| Kimata, Yoshihiro\|
備考	© 2022 by The Society of Thoracic Surgeons. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.athoracsur.2021.08.067 . \|
発行日	2021-10-03
出版物タイトル	The Annals of Thoracic Surgery
巻	114巻
号	1号
出版者	Elsevier BV
開始ページ	e51
終了ページ	e54
ISSN	0003-4975
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by The Society of Thoracic Surgeons
論文のバージョン	author
PubMed ID	34610331
DOI	10.1016/j.athoracsur.2021.08.067
Web of Science KeyUT	000833427100023
関連URL	isVersionOf https://doi.org/10.1016/j.athoracsur.2021.08.067

鳥取県西伯郡大山町岩伏し遺跡第1次・第2次発掘調査報告書

タイトル（別表記）	First and second excavation report of Iwabushi site in Tottori prefecture
フルテキストURL	fulltext20220809.pdf
著者	松本直子\|
抄録	主な遺跡は縄文時代早期押型文土器、縄文時代後期の土器・石器。縄文早期の地表面を確認、黒ボク層中で土器集中部を検出。
発行日	2016-03-25
言語	日本語
論文のバージョン	publisher
ライセンス	https://creativecommons.org/licenses/by/4.0/

Structure Selectivity of Mixed Gas Hydrates and Group 14 Clathrates

フルテキストURL	fulltext20220720-4.pdf
著者	Matsumoto, Masakazu\| Tanaka, Hideki\|
備考	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Energy Fuels, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.energyfuels.2c01337. This fulltext is available in June 2023.\|
発行日	2022-06-28
出版物タイトル	Energy Fuels
巻	36巻
号	18号
出版者	American Chemical Society (ACS)
開始ページ	10667
終了ページ	10674
ISSN	0887-0624
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 American Chemical Society
論文のバージョン	author
DOI	10.1021/acs.energyfuels.2c01337
Web of Science KeyUT	000823205000001
関連URL	isVersionOf https://doi.org/10.1021/acs.energyfuels.2c01337

On the origin and evolution of the asteroid Ryugu: A comprehensive geochemical perspective

フルテキストURL	fulltext20220708-1.pdf
著者	NAKAMURA, Eizo\| KOBAYASHI, Katsura\| TANAKA, Ryoji\| KUNIHIRO, Tak\| KITAGAWA, Hiroshi\| POTISZIL, Christian\| OTA, Tsutomu\| SAKAGUCHI, Chie\| YAMANAKA, Masahiro\| RATNAYAKE, Dilan M.\| TRIPATHI, Havishk\| KUMAR, Rahul\| AVRAMESCU, Maya-Liliana\| TSUCHIDA, Hidehisa\| YACHI, Yusuke\| MIURA, Hitoshi\| ABE, Masanao\| FUKAI, Ryota\| FURUYA, Shizuho\| HATAKEDA, Kentaro\| HAYASHI, Tasuku\| HITOMI, Yuya\| KUMAGAI, Kazuya\| MIYAZAKI, Akiko\| NAKATO, Aiko\| NISHIMURA, Masahiro\| OKADA, Tatsuaki\| SOEJIMA, Hiromichi\| SUGITA, Seiji\| SUZUKI, Ayako\| USUI, Tomohiro\| YADA, Toru\| YAMAMOTO, Daiki\| YOGATA, Kasumi\| YOSHITAKE, Miwa\| ARAKAWA, Masahiko\| FUJII, Atsushi\| HAYAKAWA, Masahiko\| HIRATA, Naoyuki\| HIRATA, Naru\| HONDA, Rie\| HONDA, Chikatoshi\| HOSODA, Satoshi\| IIJIMA, Yu-ichi\| IKEDA, Hitoshi\| ISHIGURO, Masateru\| ISHIHARA, Yoshiaki\| IWATA, Takahiro\| KAWAHARA, Kosuke\| KIKUCHI, Shota\| KITAZATO, Kohei\| MATSUMOTO, Koji\| MATSUOKA, Moe\| MICHIKAMI, Tatsuhiro\| MIMASU, Yuya\| MIURA, Akira\| MOROTA, Tomokatsu\| NAKAZAWA, Satoru\| NAMIKI, Noriyuki\| NODA, Hirotomo\| NOGUCHI, Rina\| OGAWA, Naoko\| OGAWA, Kazunori\| OKAMOTO, Chisato\| ONO, Go\| OZAKI, Masanobu\| SAIKI, Takanao\| SAKATANI, Naoya\| SAWADA, Hirotaka\| SENSHU, Hiroki\| SHIMAKI, Yuri\| SHIRAI, Kei\| TAKEI, Yuto\| TAKEUCHI, Hiroshi\| TANAKA, Satoshi\| TATSUMI, Eri\| TERUI, Fuyuto\| TSUKIZAKI, Ryudo\| WADA, Koji\| YAMADA, Manabu\| YAMADA, Tetsuya\| YAMAMOTO, Yukio\| YANO, Hajime\| YOKOTA, Yasuhiro\| YOSHIHARA, Keisuke\| YOSHIKAWA, Makoto\| YOSHIKAWA, Kent\| FUJIMOTO, Masaki\| WATANABE, Sei-ichiro\| TSUDA, Yuichi\|
発行日	2022-06-10
出版物タイトル	Proceedings of the Japan Academy, Series B
巻	98巻
号	6号
出版者	Japan Academy
開始ページ	227
終了ページ	282
ISSN	0386-2208
NCID	AA00785485
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2022 The Author(s).
論文のバージョン	author
PubMed ID	35691845
DOI	10.2183/pjab.98.015
Web of Science KeyUT	000812946100001
関連URL	isVersionOf https://doi.org/10.2183/pjab.98.015

Evaluation of Fast Diffusion Kurtosis Imaging Using New Software Designed for Widespread Clinical Use

JaLCDOI	10.18926/AMO/63739
フルテキストURL	76_3_297.pdf
著者	Kuroda, Masahiro\| Konishi, Kohei\| Sugimoto, Kohei\| Yoshimura, Yuuki\| Hamada, Kentaro\| Khasawnehc, Abdullah\| Barham, Majd\| Tekiki, Nouha\| Sugianto, Irfan\| Bamgbose, Babatunde O.\| Ishizaka, Hinata\| Shimizu, Yudai\| Nakamitsu, Yuki\| Al-Hammad, Wlla E.\| Kamizaki, Ryo\| Kurozumi, Akira\| Matsushita, Toshi\| Ohno, Seiichiro\| Kanazawa, Susumu\| Asaumi, Junichi\|
抄録	Clinical research using restricted diffusion-weighted imaging, especially diffusion kurtosis (DK) imaging, has been progressing, with reports on its effectiveness in the diagnostic imaging of cerebral infarctions, neurodegenerative diseases, and tumors, among others. However, the application of DK imaging in daily clinical practice has not spread because of the long imaging time required and the use of specific software for image creation. Herein, with the aim of promoting clinical research using DK imaging at any medical facility, we evaluated fast DK imaging using a new software program. We developed a new macro program that produces DK images using general-purpose, inexpensive software (Microsoft Excel and ImageJ), and we evaluated fast DK imaging using bio-phantoms and a healthy volunteer in clinical trials. The DK images created by the new software with diffusion-weighted images captured with short-time imaging sequences were similar to the original DK images captured with long-time imaging sequences. The DK images using three b-values, which can reduce the imaging time by 43%, were equivalent to the DK images using five b-values. The DK imaging technique developed herein might allow any medical facility to increase its daily clinical use of DK imaging and easily conduct clinical research.
キーワード	fast diffusion kurtosis imaging mean kurtosis restricted diffusion Excel ImageJ
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	297
終了ページ	305
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790360
Web of Science KeyUT	000823568300009