検索結果 336 件
| 著者 | 大塚 胗三| |
|---|---|
| 発行日 | 1927-07-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 39巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/bgeou/47111 |
|---|---|
| フルテキストURL | bgeou_147_135_144.pdf |
| 著者 | Mimura, Yukari| Ogura, Toshio| Otsuka, Fumio| |
| 抄録 | Thyroid stimulating hormone receptor antibody (TRAb) plays an important role in Graves' disease (GD). A second-generation measurement system has been developed and we have gotten a benefit by the system clinically. In this study, we determined 4 kinds of TRAb in 42 GD patients using the current and second-generation measurement systems to investigate the differences between them. The secondgeneration measurement system exhibited higher positive rates and inhibition rates of thyroid stimulating hormone (TSH) binding than those of the current system. Furthermore, 42 patients with GD were classified into 4 groups by GD activity. The actual values of all TRAbs and positive rates exhibited a tendency to increase significantly with GD activity. Of significance, 2 TRAbs in the second-generation measurement system exhibited high positive rates. However, all actual values of patients did not necessarily agree with these tendencies. The values of TRAb-human detecting anti-human TSH receptors at an approximate cut-off value reflected GD activity more accurately than those of TRAb-CT detecting anti-porcine TSH receptor. This suggests the possibility of specific differences between TSH receptors and further studies are required to further examine these effects. |
| キーワード | Graves' disease human-TRAb TSAb |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2011-06-25 |
| 巻 | 147巻 |
| 開始ページ | 135 |
| 終了ページ | 144 |
| ISSN | 1883-2423 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120003551002 |
| JaLCDOI | 10.18926/AMO/47015 |
|---|---|
| フルテキストURL | 65_5_329.pdf |
| 著者 | Matsumoto, Yoshinori| Sada, Ken-ei| Takano, Mariko| Toyota, Noriko| Yamanaka, Ryutaro| Sugiyama, Koichi| Wakabayashi, Hiroshi| Kawabata, Tomoko| Otsuka, Fumio| Makino, Hirofumi| |
| 抄録 | It is well known that infection is one of the major causes of morbidity and mortality in rheumatic disease patients treated with high-dose glucocorticoids, especially in the early phase after achievement of disease remission. The aim of this study was to identify the risk factors for infection, with a focus on the dose of glucocorticoids administered, following the achievement of disease remission in rheumatic diseases patients. We retrospectively analyzed the medical records of rheumatic disease patients who had been treated with glucocorticoids. The primary endpoint was the incidence rate of infection during a period from 1 to 2 months after the commencement of treatment. From April 2006 to March 2010, 19 of 92 patients suffered from infection during the observation period. Age≧65 yrs, presence of interstitial pneumonia, diagnosis of systemic vasculitis and serum creatinine level≧2.0mg/dl were found to be univariate predictors for infection. However, only the presence of interstitial pneumonia was an independent risk factor for infection (HR＝4.50, 95%CI＝1.65 to 14.44) by the Cox proportional hazard model. Even after achievement of clinical remission, careful observation is needed for patients with interstitial pneumonia, more so than for those receiving high-dose glucocorticoids. |
| キーワード | infection rheumatic disease glucocorticoids interstitial pneumonia risk factors |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 329 |
| 終了ページ | 334 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037270 |
| Web of Science KeyUT | 000296116400007 |
| 著者 | Tsukamoto, Naoko| Otsuka, Fumio| Miyoshi, Tomoko| Inagaki, Kenichi| Nakamura, Eri| Suzuki, Jiro| Ogura, Toshio| Iwasaki, Yasumasa| Makino, Hirofumi| |
|---|---|
| 発行日 | 2011-01-30 |
| 出版物タイトル | Molecular and Cellular Endocrinology |
| 巻 | 332巻 |
| 号 | 1-2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Momota, Ryusuke| Naito, Ichiro| Ninomiya, Yoshifumi| Ohtsuka, Aiji| |
|---|---|
| 発行日 | 2011-05 |
| 出版物タイトル | Matrix Biology |
| 巻 | 30巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 西江 学| 岩川 和秀| 濱野 亮輔| 徳永 尚之| 常光 洋輔| 大塚 真哉| 稲垣 優| 岩垣 博巳| 合原 大博| 藤田 勲生| 村上 敬子| 友田 純| |
|---|---|
| 発行日 | 2011-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 西江 学| 大塚 真哉| 友田 純| 藤原 敬士| |
|---|---|
| 発行日 | 2011-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 秋山 麻里| 小林 勝弘| 吉永 治美| 大塚 頌子| |
|---|---|
| 発行日 | 2011-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大塚 胗三| |
|---|---|
| 発行日 | 1928-04-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 40巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大塚 胗三| |
|---|---|
| 発行日 | 1929-05-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 41巻 |
| 号 | 5号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大塚 蕃| 寺尾 尚文| 杉生 喜三| |
|---|---|
| 発行日 | 1932-09-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 44巻 |
| 号 | 9号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大塚 信夫| |
|---|---|
| 発行日 | 1957-04-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 69巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大塚 信夫| |
|---|---|
| 発行日 | 1957-04-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 69巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大塚 信夫| |
|---|---|
| 発行日 | 1957-04-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 69巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大塚 利昭| |
|---|---|
| 発行日 | 2000-06-10 |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 巻 | 32巻 |
| 号 | 1号 |
| 資料タイプ | 一般雑誌記事 |
| JaLCDOI | 10.18926/OER/40591 |
|---|---|
| タイトル（別表記） | Dynamic Externalities of Industrial Agglomeration : A Survey |
| フルテキストURL | oer_035_4_027_050.pdf |
| 著者 | 大塚 章弘| |
| 抄録 | This paper reviews existing literature on dynamic externalities which is the fountainhead of competitive advantages, and argues that rigorous theoretical and empirical analysis is needed to increase understanding of the role of technological spillovers in generating regional growth. Empirical analysis of knowledge spillovers is broadly performed in the field of industrial organization. Recently, a number of empirical analyses aiming at verifying technological spillovers accompanying R&D activity of companies have been conducted. In recent empirical literature on spatial agglomeration, many papers find evidence consistent with dynamic externalities. Especially, growing bodies of research have estimated the extent and type of dynamic externalities. Despite the different data sources used, methodologies are similar. As the survey of some methodologies has been carried out by McDonald (1997), this paper reviews the main empirical analyses of dynamic externalities as the complement−positioning. |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2004-03-10 |
| 巻 | 35巻 |
| 号 | 4号 |
| 開始ページ | 27 |
| 終了ページ | 50 |
| ISSN | 0386-3069 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002647269 |
| 著者 | 濱野 亮輔| 大塚 眞哉| 木村 裕司| 西江 学| 徳永 尚之| 宮宗 秀明| 常光 洋輔| 稲垣 優| 岩川 和秀| 岩垣 博巳| |
|---|---|
| 発行日 | 2010-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 山下 徹| 神谷 達司| 出口 健太郎| 稲葉 俊東| 張 漢哲| 商 敬偉| 宮崎 一徳| 大塚 愛二| 片山 泰朗| 阿部 康二| |
|---|---|
| 発行日 | 2010-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/40502 |
|---|---|
| フルテキストURL | 64_5_277.pdf |
| 著者 | Kumase, Fumiaki| Morizane, Yuki| Mohri, Satoshi| Takasu, Ippei| Ohtsuka, Aiji| Ohtsuki, Hiroshi| |
| 抄録 | Endothelial glycocalyx (GCX) has been reported as a protective factor for vascular endothelial cells (VEC) in diabetes and hypertension. However, the involvement of GCX impairment in ocular vasculopathy remains unclear. We evaluated the changes in the GCX thicknesses of the retinal and choroidal capillaries in rats with diabetes and hypertension by cationic colloidal iron staining using a transmission electron microscope. In the control group, the mean (standard error of the mean) thicknesses of retinal and choroidal GCX were 60.2 (1.5) nm and 84.3 (3.1) nm, respectively. The diabetic rats showed a significant decrease of GCX thickness in the retina, but not in the choroid, compared to controls (28.3 (0.3) nm, p＜0.01 and 77.8 (1.4) nm, respectively). In the hypertensive rats, both retinal and choroidal GCX were significantly decreased compared to the control values (10.9 (0.4) nm and 13.2 (1.0) nm, respectively, both p＜0.01). Moreover, we could visualize the adhesion of leukocytes and platelets on the luminal surface of VEC, at the site where the GCX was markedly degraded. These findings suggest that the GCX prevents adhesion of leukocytes and platelets to the VEC surface, and this impairment may lead to ocular vasculopathy in diabetes and hypertension. |
| キーワード | glycocalyx retina choroid diabetes hypertension |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 277 |
| 終了ページ | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975760 |
| Web of Science KeyUT | 000283563300002 |
| JaLCDOI | 10.18926/AMO/40128 |
|---|---|
| フルテキストURL | 64_4_213.pdf |
| 著者 | Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Makino, Hirofumi| |
| 抄録 | Aldosterone production occurs in the adrenal cortex, and is regulated primarily by angiotensin II (Ang II), potassium and adrenocorticotropin (ACTH). In the presence of the aldosterone stimulators, steroidogenesis is further governed by local autocrine and/or paracrine factors in the adrenal cortex. We reported the presence of functional bone morphogenetic protein (BMP) system in the adrenal cortex and also demonstrated that BMP-6 increases Ang II-induced aldosterone production, which could be involved in the "aldosterone breakthrough" phenomenon. Aldosterone breakthrough is the phenomenon by which circulating aldosterone concentrations increase above pre-treatment levels after long-term therapy with ACE inhibitors or Ang II type 1 receptor antagonists (ARB). This phenomenon may lead to important clinical consequences since increased aldosterone in a high-salt state facilitates cardiovascular and renal damage in hypertensive patients. We found that long-term ARB treatment reverses the reduction of aldosterone synthesis by adrenocortical cells, thereby causing "cellular aldosterone breakthrough". The availability of BMP-6 in the adrenal cortex may be at least partly involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB. |
| キーワード | adrenal cortex angiotensin II aldosterone bone morphogenetic protein |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 213 |
| 終了ページ | 218 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802537 |
| Web of Science KeyUT | 000281384400001 |