検索結果 3545 件
| JaLCDOI | 10.18926/AMO/40501 |
|---|---|
| フルテキストURL | 64_5_267.pdf |
| 著者 | Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka| |
| 抄録 | In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation. |
| キーワード | intracranial self-stimulation behavior motivational effect methamphetamine nicotine |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-10 |
| 巻 | 64巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 267 |
| 終了ページ | 275 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20975759 |
| Web of Science KeyUT | 000283563300001 |
| JaLCDOI | 10.18926/OER/40500 |
|---|---|
| フルテキストURL | oer_037_2_057_063.pdf |
| 著者 | Yokoo, Masanori| |
| 抄録 | In many standard undergraduate textbooks of macroeconomics, open economies are discussed by means of the Mundell−Fleming model, an open macroeconomic version of the IS−LM model. This short paper develops a simple differential−equation version of the dynamic Mundell−Fleming model, taking account of two key assumptions : (i) the Marshall−Lerner condition is globally violated and (ii) the investment function depends nonlinearly on the current output level. Under our settings, we demonstrate that the exchange rate and the other relevant variables can display persistent fluctuations due to the occurrence of a stable limit cycle. We also discuss a paradox that the resulting dynamics may well be consistent with the J−curve effect. |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2005-09-10 |
| 巻 | 37巻 |
| 号 | 2号 |
| 開始ページ | 57 |
| 終了ページ | 63 |
| ISSN | 0386-3069 |
| 関連URL | http://www.e.okayama-u.ac.jp/gakkai/ |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002514605 |
| JaLCDOI | 10.18926/OER/40447 |
|---|---|
| タイトル（別表記） | Market Risk and Private Risk −Financial Appraisal of Investment Projects− |
| フルテキストURL | oer_037_1_035_051.pdf |
| 著者 | 小山 泰宏| |
| 抄録 | The purpose of this paper is to examine one of the functions which entrepreneurs may play in the course of industrial development through a case study of Japan’s RPG development race. As Japan’s toy manufacturers often said, their market was characteristic of its small size and considerable demand volatility in comparison to other consumer products. Entrepreneurs must have seen any commitment to a cutting edge product, video games, as only a gamble and therefore behaved in a trial−and−error way. Furthermore, judging from the fact that no one could imagine the video game would come to turn over ¥1500 billion in 20 years, the firm level trial−and−errors and their subsequent variety of strategies on the industry level must have been the key to understand the unexpected market growth and technical evolution. However, recent management thoughts told us that the strategic variety in an industry could be possibly indulged by various pressures towards homogeneity. Such counter powers are referred to as organizational isomorphism, strategic bandwagon effects and so on. To examine those pressures which drive entrepreneurs back and forth towards strategic variety, this paper looks at the structural characteristics which underlie the way entrepreneurs see things in an uncertain environment. The case analysis takes the view that the video game industry was so uncertain that nothing could affect so deterministically entrepreneurs’ behaviours other than their perceptions. As a conclusion here, this paper points out some tradeoffs underlying the two different strategies which the twin peaks of Japanese RPG producers, Square and Enix, employed to meet with the uncertainty of the infant RPG market. It also argues that these tradeoffs based on two different perceptions might have kept their startups from the isomorphic indulgence. As a more prospective argument, questioned is the quality of strategic variety which is often deemed as an unquestionable remedy to industrial stagnation. |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2005-06-10 |
| 巻 | 37巻 |
| 号 | 1号 |
| 開始ページ | 35 |
| 終了ページ | 51 |
| ISSN | 0386-3069 |
| 関連URL | http://www.e.okayama-u.ac.jp/gakkai/ |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002509311 |
| JaLCDOI | 10.18926/OER/40446 |
|---|---|
| タイトル（別表記） | Entrepreneurial Choices in Strategic Options in Japan’s RPG Development |
| フルテキストURL | oer_037_1_019_034.pdf |
| 著者 | 藤井 大児| |
| 抄録 | The purpose of this paper is to examine one of the functions which entrepreneurs may play in the course of industrial development through a case study of Japan’s RPG development race. As Japan’s toy manufacturers often said, their market was characteristic of its small size and considerable demand volatility in comparison to other consumer products. Entrepreneurs must have seen any commitment to a cutting edge product, video games, as only a gamble and therefore behaved in a trial−and−error way. Furthermore, judging from the fact that no one could imagine the video game would come to turn over ¥1500 billion in 20 years, the firm level trial−and−errors and their subsequent variety of strategies on the industry level must have been the key to understand the unexpected market growth and technical evolution. However, recent management thoughts told us that the strategic variety in an industry could be possibly indulged by various pressures towards homogeneity. Such counter powers are referred to as organizational isomorphism, strategic bandwagon effects and so on. To examine those pressures which drive entrepreneurs back and forth towards strategic variety, this paper looks at the structural characteristics which underlie the way entrepreneurs see things in an uncertain environment. The case analysis takes the view that the video game industry was so uncertain that nothing could affect so deterministically entrepreneurs’ behaviours other than their perceptions. As a conclusion here, this paper points out some tradeoffs underlying the two different strategies which the twin peaks of Japanese RPG producers, Square and Enix, employed to meet with the uncertainty of the infant RPG market. It also argues that these tradeoffs based on two different perceptions might have kept their startups from the isomorphic indulgence. As a more prospective argument, questioned is the quality of strategic variety which is often deemed as an unquestionable remedy to industrial stagnation. |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2005-06-10 |
| 巻 | 37巻 |
| 号 | 1号 |
| 開始ページ | 19 |
| 終了ページ | 34 |
| ISSN | 0386-3069 |
| 関連URL | http://www.e.okayama-u.ac.jp/gakkai/ |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002509310 |
| JaLCDOI | 10.18926/40383 |
|---|---|
| タイトル（別表記） | ON THE DETECTION OF RADIOACTIVE SPRING BY GROUND WATER |
| フルテキストURL | 009_037_042.pdf |
| 著者 | 杉原 健| |
| 抄録 | The author determined the radon content in the ground waters of Misasa and its vicinity by the I. M. fontactoscope from August to November, 1952. The results and conclusions are as follocvs : A close correlation was observed between the radon contents in the spring-waters and that in the ground-waters near the springs, so it seems possible to prospect the existence of radioactive springs by determination of the radon content in groundwaters in the place where no radioactive spring was found as yet. The highest radon content in 53 samples was 741 Mache (2697×10(-10) Curie/l) of the Mr, shigemasa Matsubara's well-water, and this record ecceeds the highest radon content in thermal waters of Misasa known up to the present time. Though the temperature of its well-water was 24.0°C in the afternrnoon of November 25th, 1952, the hot-springs of Yamadaku-kyodoYu, Gunzeshinsenryo, Koyoen, and so on, issue neare by the well. Therefore, the author points out that if a boring is tried in the place where the well is the centre, a most strongly radioactive hot spring in the world may issue. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1953-01 |
| 巻 | 9巻 |
| 開始ページ | 37 |
| 終了ページ | 42 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40388 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532515 |
| JaLCDOI | 10.18926/40382 |
|---|---|
| タイトル（別表記） | ON THE DISTRIBUTION OF THE NITRATE CONTENT IN THE MISASA HOT SPRINGS, TOTTORI PREFECTURE |
| フルテキストURL | 009_032_036.pdf |
| 著者 | 杉原 健| |
| 抄録 | The author determined the nitrate content in Misasa Hot-Springs, sampled from August to October, 1952, In all the well-waters, the amounts of nitrate were higher than 1mg/l, and the highest nitrate content was 9.6mg/l in the well-water in front of Mr. Aoki, s house. In the hot-springs, the author found 10 springs containing more than 1 mg/l of nitrate, and the highest nitrate content was 9.0 mg/l in the Hakuro-Yu, but the lotvest content was about 0 mg/l in the Iwasaki Hot-Springs. In Ishiyu and "Yamadaku-KyodoYu" during the stay of irrigation water in rice-fields from the rain season to September, the amounts of flow incrensed, but the content of radon and chloride decreased. On the other hand, in Hisui-no-yu, the chloride content decreased and the radon content increased with the amount of flow. Moreover, the amounts of nitrate were considerably high in the Ishiyu and Yamndaku-KyodoYu Hot Springs, but fairly low in the Hisui-no-Yu. So the author expects that some relation may be found between the variation of the radon content and the amounts of nitrate. The water samples, which nitrate contents were high, showed a tendency to have a high phosfate content generally. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1953-01 |
| 巻 | 9巻 |
| 開始ページ | 32 |
| 終了ページ | 36 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40388 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532514 |
| JaLCDOI | 10.18926/40378 |
|---|---|
| タイトル（別表記） | STUDIES ON THE CHLORIDE AND SULFATE CONTENT OF WELL WATERS AND THE AMOUNTS OF CHLORIDE AND SULFATE FIXED TO THE SOIL IN THE MINERAL SPRING DISTRICTS (IV) TAMATSUKURI HOT-SPRINGS, SHIMANE PREFECTURE, JAPAN |
| フルテキストURL | 009_016_019.pdf |
| 著者 | 梅本 春次| |
| 抄録 | In Tamatsukuri Hot-Springs, the chloride and sulfate content and water temperatures of well waters and the amounts of chloride and sulfate fixed to the soil were determined with the samples collected from various parts of the mineral spring districts. For the values which were determined with samples collected from the thermal spring districts and its neighbourhood, no difference was recognized. This result is quite different from the results given in the previous reports of the present author. But this fact may be explaned as the effects of the sea warter, and the further study is being continued. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1953-01 |
| 巻 | 9巻 |
| 開始ページ | 16 |
| 終了ページ | 19 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532512 |
| JaLCDOI | 10.18926/40331 |
|---|---|
| タイトル（別表記） | MEDICAL STUDIES ON THE RURAL PEOPLE (I) CLINICAL AND STATISTICAL OBSERVATIONS ON HOOKWORM DISEASE IN RURAL DISTRICTS |
| フルテキストURL | pitsr_014_045_050.pdf |
| 著者 | 森永 寛| |
| 抄録 | The author studied statistically 160 cases of hookworm infection who had been admitted to Misasa Branch of Okayama University Hospital, Misasa Hot Springs in Tottori prefecture, during 1946~1949 and 162 cases of out-patients with anchylostomiasis in Yakage Hospital, Okayama Prefecture, during 1949～1950. The clinical findings were as follows: (1). Females showed a higher incidence than males and the incidence ratio of infected persons to total out-patients increased with age up to the 50~69 years group. (2). The most patients consulted our hospital for the first time in April～May and in August, and 62 per cent of cases came within 3 months scince they had noticed disorders in some way, but 22% remained at home without medical cure more than a year. (3). Chief subjective complaints were palpitation of heart (35.3%), lassitude of legs (31.2%), pains in the abdomen (22.9%), feeling of dizziness (21.6%) and so on. (4). Laboratory findings: The total number of erythrocytes was between 1.23 and 5.54 millions per cubic millimeter and a moderate anemia almost always developed in the hookworm disease (77.9% of all cases). The number of white cells was normal or slightly increased. Relative or absolute eosinophilia was recognized in 83.5% of all patients. Wassermann's test was positive in 20%, and Takata's reaction positive in 53% of the cases. The acidity of the gastric juice was lower than normal. Hypo- and anacidity were verified in 58%. Both albumen and urobilinogen test in urine were positive in 5.4% of 61 cases. Sugar in none. (5). Treatment: Thymol, tetrachlorethylene and oil of chenopodium were used alternately to remove the worms. The eggs in stool became negative after 3-4 times of the administration of anthelmintics in 76 per cent of 151 cases. As mentioned above, the patients infected with hookworm had various functional disorders of bodies, but they consulted the hospital only when the farmer's busy season began and their trouble became unbearable. And then the recovery of anemia took a month or two. Prof. Kitayama reported that the cold environment under 9°C. in the winter had perished the larva of hookworm in the soil. From these viewpoints, the author proposed that examination and cure of hookworms should be carried out in the winter, the slack season for farming, to prevent the fall of working ability due to anchylostomiasis during the busy farming seasons. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1954-03 |
| 巻 | 14巻 |
| 開始ページ | 45 |
| 終了ページ | 50 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40330 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462906 |
| JaLCDOI | 10.18926/40321 |
|---|---|
| タイトル（別表記） | SEASONAL VARIATION OF GASTRIC ACIDITY |
| フルテキストURL | pitsr_016_031_034.pdf |
| 著者 | 森永 寛| |
| 抄録 | Since, in Japan situated in the temperate zone, climatic change through the four seasons of a year is regular, it is expected that there the physiological reactions of the human body may vary regularly in accordance with the climatic change. In fact, we experience that the attacks of diseases and their conditions are in close connection with the changes of the seasons. The author investigated the effect of the seasons upon the human gastric acidity, by means of the coffein-test, in 580 cases with gastrointestinal disorders, at the Misasa Branch Hospital of Okayama University, Misasa Spa in Tottori Prefecture, in 1946～1946. Hyperacidity was verified in 194 (33%) of 580 cases, normacidity in 134 (23%), anacidity in 138 (24%) and hypacidity in 114 (20%). The percentage of hyperacidity increases in winter (41%), decreases in spring (32%) and in summer (28%), and increases again in autumn (34%). The cases of anacidity decrease in winter and spring, but increase in summer. In chi-square test, the season and the acidity of gastric juice were taken as factors of variation. The chi-square was computed with the result: Pr {X(3)=14.013<16.919} =5%, so it cannot be asserted that the seasonal changes effect the acidity of gastric juice. But if Comparison is made between summer and winter with respect to the anacidity-hypacidity vs. the hyperacidity, the author: obtains Pr {X(2)=6.06> 5.412} =2%. It is thus verified that the cases of hyperacidity predominate over those of anacidity-hypacidity in winter, while the relation is reverse in summer. As was mentioned above, the tendency is obvious that the acidity of gastric juice decreases in summer and increases in winter. It was found that there is a regular seasonal variation in gastric acidity. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1956-01 |
| 巻 | 16巻 |
| 開始ページ | 31 |
| 終了ページ | 34 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40318 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462901 |
| 著者 | 山口 鎌次| |
|---|---|
| 発行日 | 1957-09 |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 巻 | 19巻 |
| 資料タイプ | 会議発表論文 |
| JaLCDOI | 10.18926/40272 |
|---|---|
| タイトル（別表記） | THE CHANGE IN CONCENTRATION OF FERROUS IRON AND REDUCIBLE IRON, DISSOLVED IN SPRING WATER AT MISASA HOT SPRINGS, JAPAN, DURING PRESERVATION OF THE WATER SAMPLE IN A SEALED BOTTLE |
| フルテキストURL | pitsr_020_048_054.pdf |
| 著者 | 田中 重男| |
| 抄録 | The two sprigns called "Tanaka-no-Yu" and "Hisui-no-Yu" at Misasa Hot Springs, japan (Fig. 1), suitable for sampling the unpolluted water, the locations of which, are shown in Fig. 2, were chosen for this study. The o-phenanthroline method, details of which were discussed in the previous report by the author (Repts. Balneol. Lab. Okyama Univ., 17, 1, (1956)) was used for the determination of ferrous iron, ferrous iron + reducible iron, and ferrous iron + reducible iron + colloidally dispersed iron (to be referred to as "total irons" in this report). For comparison, the change in concentratin of iron dissolved in distilled water during preservation in a sealed bottle was observed, and the results obtained for the solutions with the pH values of 5.4 and 5.8 are illustrated in Fig.3 and Fig.5, rspectively. Both ferrous and reducible iron disappear within 5 minutes, when the pH of the solution is 6.4. The hydrogen ion concentration was thus seen to give a sensitive effects on the speed of diminution of ferrous and reducible iron dissolved in the distilled water. It should be noticed that no appreciable diminution was observed during the period from 60 min. to 120 min,. It is probable that the diminution of total iron is caused by the adsorption of colloidal iron hydroxides on the wall of glass bottle. The effects of charged anion (SO(4)(--)) on the change in concentration of iron during preservation was also investigated, but no appreciable effect was found. (Fig. 5 and Fig. 6). Fig.7, Fig.8, and Fig.9 show the change in concentration of iron during preservation of the spring water at "Tanaka-no-Yu". The content of iron in the spring water is about 0.3 mg/l, and its pH value is about 7.1. For the first 30 minutes, ferrous iron diminishes rapidly, the slope of the diminution curve being sharp and almost straight. Thereafter the slope becomes gentler, and, after an hour, the slope approaches nearly zero. On the other hand, ferrous iron dissolved in distilled water disappears in a moment at the same pH 7.1. Fig.10, Fig.11, and Fig.12 show the change in concentration of iron during preservation of the spring water at "Hisui-no-Yu". The content of iron in the spring water is about 1.0 mg/l, and its pH value is about 6.4. In this case, the diminution of ferrous iron is not remarkable, and only 20% of the initial quantity diminishes within 2 days. Whereas, in the case of distilled water, the diminution is very rapid at the same pH 6,4, and the ferrous iron disappears completely within 5 minutes. In Fig.13 the speed of diminution of iron in distilled water and that in spring water are compared. The difference here seen may probably be due either to that the ferrous iron in spring water is in a certain complex form not easily oxidizable, or to that the spring water contains some reducing substances. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-01 |
| 巻 | 20巻 |
| 開始ページ | 48 |
| 終了ページ | 54 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462895 |
| JaLCDOI | 10.18926/40259 |
|---|---|
| タイトル（別表記） | Study of Togo -Matsuzaki Hot Springs, Tottori Prefecture |
| フルテキストURL | pitsr_023_001_022.pdf |
| 著者 | 梅本 春次| 原田 光| 岡部 茂| 宮腰 潤一郎| 阪上 正信| 田中 昌也| 御船 政明| |
| 抄録 | 1. Layers containing thermal water in this district are thin, and lie at different depths (about 35, 55, and 60 meters) from the ground surface. There are evidences to show that these layers are intimately connected with one another. 2. The authors may suppose the existence of a structurally weak zone, along the line from Matsuzaki to Asozu, within which the issuing spots of thermal springs are located. 3. The head water levels of the thermal springs in this district are closely related with that of Lake Togo. Keeping pace with the variations of the water levels of Lake Togo and of artesian wells in its vicinity, the rate of flow of thermal springs vary; and the correlation between these variations is apparent. 4. The pumping suction of thermal water at one spring affects the flow of water at other springs within distances of 150 to 200 meters therefrom, though the direct sources of thermal water supply for the latter springs may be different from that of the former. 5. The spring water in this district is considered to be a mixture of hot water, containing sodium, calcium, chloride, and sulfate ions, and cold water, containing bicarbonate ion. The diversity of chemical constitutions of different spring waters is explained as due to the difference in proportion in which the hot and cold waters are mixed. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-10 |
| 巻 | 23巻 |
| 開始ページ | 1 |
| 終了ページ | 22 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40258 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462891 |
| JaLCDOI | 10.18926/40255 |
|---|---|
| タイトル（別表記） | A Case of Agammaglobulinemia |
| フルテキストURL | 024_087_095.pdf |
| 著者 | 松本 欣之| 涌谷 卓伯| |
| 抄録 | A case of agammaglobulinemia, probably of the secondary type, is reported in adult female (45-year-old) with tumor of the mediastinum. The authors described the bibliographical consideration and arose the attention of agammaglobulinemia. Reports on agammaglobulinemia may increase in practise if electrophoresis of the serum protein-fraction is used as a routine examination method. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1959-01 |
| 巻 | 24巻 |
| 開始ページ | 87 |
| 終了ページ | 95 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532364 |
| JaLCDOI | 10.18926/40254 |
|---|---|
| タイトル（別表記） | General Survey of the Spa Treatment at Misasa Spa, Tottori Prefecture |
| フルテキストURL | pitsr_024_080_086.pdf |
| 著者 | 涌谷 卓伯| 松本 欣之| 山本 泰久| |
| 抄録 | Misasa Hot Spring is one of the most famous radioactiye hot springs in Japan. A general survey of the spa treatment at Misasa Spa was carried out in Feburary, 1957. The informations we have gathered may be summarized as follows: 1). The number of the spa visitors seeking for curative treatment was almost equally divided between men and women and the majority of the spa visitors was over 50 years old. 2). 65% of the spa visitors came to this hot spring with the specific purpose of balneotherapy. 19.3% came for rest, 13.3% for the purpose of after-care. 3). Those who visited Misasa Spa for the first time were 44.7%, the rest being those who visited this spa over 2 times. 18.3% of them had consultation with or were under the direction of a physician. 4). The length of time they stay at this spa for curative treatment: 41.6% of the spa visitors stay for 8～14 days, 17.9% of them 15～20 days and 31% of them over three weeks. 5). About 74% of the spa visitors bathe 3 to 5 times a day for curative treatment, and 82% of them drink hot spring water. 6). Symptoms of bathing reaction such as generalised fatigue, constipation, loss of appetite, joint pain, abdominal pain and so on were observed in 50% of the spa visitors. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1959-01 |
| 巻 | 24巻 |
| 開始ページ | 80 |
| 終了ページ | 86 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462890 |
| JaLCDOI | 10.18926/40251 |
|---|---|
| タイトル（別表記） | Clinical and Experimental Studies of Therapeutic Effects of Radioactive Thermal Bath on Peripheric Disorders of Circulation Part 4 Therapeutic Effects of Radioactive Thermal Bath on Blood pressure |
| フルテキストURL | 024_001_028.pdf |
| 著者 | 松本 欣之| |
| 抄録 | 1) The effects of a single bath in the radioactive hot spring on the blood pressure and the pulse rate. The author observed the changes of the blood pressure and the pulse rate of subjects bathing for 20 minutes, 39°± 1°C, in temperature, in the radioactive hot spring in Misasa. It may be summerized as follows (Table 2, Fig. 1). a. In the hypertensive group (maximal blood pressure······181 mm. Hg. and over), the maximal blood pressure had decreased immediately after bathing, and remained at this level even 2 hours after bathing. The minimal blood pressure reacted in the same manner as the maximal blood pressure. b. The moderate hypertensive group (maximal blood pressure······180-161 mm. Hg.). In a few instances, the maximal blood pressure had increased immediately after bathing, but decreased within 30-90 minutes after bathing. Changes in the minimal blood pressure were not so remarkable. c. In the normal group (maximal blood pressure······160～101 mm. Hg.), the maximal blood pressure had lowered within 30-90 minutes after the radioactive hot spring bathing. The minimal blood pressure showed no significant changes. b. The pulse rate had increased immediately after bathing in all groups, but within 30 minntes had returned to the initial rate and there were no further changes for 2 hours (Table 2, Fig. 2). 2) The effects of a radioactive vapour bath on the blood pressure and the pulse rate. After a bathing in vapour bath (10～15 minutes), the maximal and the minimal blood pressure showed mild decrease for 2 hours. The changes of the pulse rate and the pulse amplitude were not so remarkable (Table 3, Fig. 3). 3) The effects of a series of baths in the radioactive spring on the blood pressure. The author observed the changes in the blood pressure of the subjects bathed 2 or 3 times daily in the radioactive hot spring in Misasa, at a temperature of 42～43°C., 5～10 minutes. The blood pressure of subjects was measured once a day (at 7 a.m.) for the first week, and subsequently once weekly for two additional weeks. Subjects with an initial maximal blood pressure over 160 mm. Hg. showed a fall on the second day of the spa treatment followed by a temporary rise on the 3rd or 4th day, after which the pressure fell to the 2nd day level again, and then remained fairly constant to the end of the observation period. Subjects with an initial blood pressure under 159 mm. Hg. also showed a fall in the course of the spa treatment, but the degree of the fall was slighter than that of the former (Table 4, Fig. 4). This tendency was also observed on the out-patients (Table 5, Fig. 5). The changes of the blood pressure and pulse rate of subjects after a bath for 20 minutes, in water 39±1°C. in temperature, on the first day of the spa therapy were compared with those occuring on the 6th or 7th day, and it was observed that the patterns of the changes in blood pressure following bathing on the two days were significantly different (i.e. on the latter, so called "the initial blood pressure increase following the bathing" was not observed) (Table 6,7,8, Fig.6,7,8,9,). 4) The remote investigation on the spa visitors with hypertension and/or arteriosclerosis. The author investigated the course of patients with hypertension and/or arteriosclerosis who received the spa treatment at Misasa after returned to home. The incidence of subjects who answered as being good was 86%, and it was observed the fall of the maximal and the minimal blood pressure, especially the fall was remakable in subjects who stayed at spa about 4 weeks (Table 10, 11, 12, 13, 14, 15, Fig. 10). 5) The incidence of hypertension among the residents in the spa resort and those residing in other places. The author measured the blood presssre of the out-patients of his institute over 41 years of age from June, 1956 to May, 1957. The incidence of patients with the maximal blood pressure over 160 mm. Hg. was 16.4% in spa resort, and 25.7% in places where there are no hot springs. Using x(2)-test, the difference between the two was recognised as being significant (Table 16, 18). 6) Comparison of the mortality rate of patients with hypertension between residents in the spa resort and those residing in other places. The author examined the mortality rate of persons with hypertension in the area under the jurisdiction of the Kurayoshi Sanitary Institute, Tottori prefecture, from 1954 to 1956. The rate of mortality in the spa resort was 17.5% as compared to 21.4% in other places (Table17). |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1959-01 |
| 巻 | 24巻 |
| 開始ページ | 1 |
| 終了ページ | 28 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40250 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532368 |
| JaLCDOI | 10.18926/40248 |
|---|---|
| タイトル（別表記） | Clinical Studies on Anemia in Rheumatoid Arthritis |
| フルテキストURL | pitsr_025_053_069.pdf |
| 著者 | 山本 泰久| |
| 抄録 | Anemia of moderate severity is commonly present in patients suffering from rheumatoid arthritis, but one to which little attention has been paid and despite its frequency the exact mechanism of its production is uncertain. Anemia in rheumatoid arthritis is refractory to anti-anemic therapy. The presence of anemia may hinder adequate physical or orthopedic treatment and may produce a degree of lassitude that considerably aggravates the joint disability. This anemia, therefore, seemed worthy of study and investigations of three aspects are reported here: 1. Changes in peripheral blood, bone marrow, liver function and gastric acidity. 2. Alternations in iron metabolism. 3. Balneotherapy and anemia in rheumatoid arthritis. I. Peripheral Blood Picture, Liver Function, Serum Protein Fraction and Gastric Acidity. 1. The peripheral blood and bone marrow. The number of erythrocytes is 558～216×10(4)/c. mm. (average:402×10(4)/c. mm.), hemoglobin-content:110～40% (average: 78.6%), and the color index is about 1.0. The anemia of rheumatoid arthritis treated is mostly normochromic. The white blood cell count is between 11200 and 3720/c. mm. (average: 7504/c. mm.), and the number of leucocytes in 80% of the cases ranges within the normal limits. Eosinophilia is observed 27% of the cases. Films of the sternal marrow showed no major abnormality in the eight cases examined. Several minor points, however, deserve mention. The nucleated cell count was diminished in seven cases examined, and the decrease of normoblasts in bone marrow would explain the reduced red cell count in peripheral blood. The myeloid series showed a relative increase. 2. Liver function tests and gastric acidity. To illustrate the possible appearance of liver function disturbances in connection with rheumatoid arthritis, the author has made different liver function tests on patients suffering from this disease. From the results it appears that in protein metabolism tests more than 83% of the cases gave abnormal albumin/globulin ratios and Takata's and erthrocyte sedimentation reactions. The detoxication capacity determined by hippuric acid synthesis tests had decreased in 25% of the cases examined. The dye excreting capacity, determined by the bromsulfalein tolerance test, was found to be reduced in 64% of the cases examined. The urin-urobilinogen test showed positive in 28% of the cases. In all cases the insulin sensitivity test gave pathological readings. Of 40 cases examined, anacidity of gastric juice was observed in 17 cases, subacidity in other 10 cases and normacidity, hyperacidity in remammg 13 cases. Thus, a decrease in the gastric acidity was found to occur in 67.5% of the cases. 3. Serum protein fraction. The total serum protein of 31 cases with rheumatoid arthritis appeared to be on the same level as in normal material. Serum protein fraction was determined in 19 cases by paperelectrophoresis. In rheumatoid patients, albumin fraction of serum protein decreased and γ-globulin fraction increased in all cases examined, compared with the data of normal subject as a control. Alubumin/globulin ratio of rheumatoid arthritis was below the 5% rejection limit of normal value. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1959-05 |
| 巻 | 25巻 |
| 開始ページ | 53 |
| 終了ページ | 69 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40244 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462889 |
| JaLCDOI | 10.18926/40247 |
|---|---|
| タイトル（別表記） | Studies on the Influences of Balneal Treatment on Female Sexual Function |
| フルテキストURL | pitsr_025_025_052.pdf |
| 著者 | 長谷川 安正| |
| 抄録 | In the present study, observations of changes on female sexual function by balneal treatment were carried out with female rats with respects to sexual cycle, histological changes in ovary and uterus, histo-chemical changes in pituitary, cholinesterase activity in brain, cholesterol levels in ovary, etc. The results obtained were as follows. 1) Significant changes of sexual cycle appeared in 47 (62%) out of the 76 rats which were treated with several kinds of artificial balneal water at the temperature of 42°C (for 5 minutes per single course of the balneal treatment, twice daily during 4 weeks). Similar changes of sexual cycle also appeared in the subjects which were treated with the same kinds of balneal water at 37°C, though having showed to be less than the changes in case of the balneal treatment at 42°C. 2) A significant tendency of regulating sexual cycle of rat to normal was demonstrated in the subjects which were treated with artificial balneal sulfer, and on the other hand, a significant tendency of disturbing the cycle was demonstrated in the sUbjects which were treated with artificial balneal acid and alkali. 3) A tendency of extending the period of dioesterus phase in sexual cycle of rat was found in the subjects which were treated with our laboratory' balneal water at 42°C for 10 minutes per single course four times daily during 10 days. In these subjects, it was also demonstrated that the period of the estrus phase tended to be prolonged. 4) Histological pictures in ovary and uterus indicated normal growth in the subjects of which the sexual cycles were normalized by balneal treatment, whereas indicated an atrophy in the subjects of which the cycles were disturbed. Significant atrophy tended to appear remarkably in the subjects which developed some irregular cycles due to the treatment with artificial balneal acid or alkali. In view point of the daily changes in these tissues, it was demonstrated that atrophic changes appeared at the 10th day after onset of the treatment with a balneal water at 42°C for 5 minutes per single course or with a balneal water at 37°C for 5 minutes, and then turned to normal pictures at the 20th day after onset of the treatment. It was also indicated that remarkable atrophic changes in ovary and uterus appeared immediately after 10 days treatment with a balneal water at 42°C for 10 minutes per single course four times daily, and then turned to show a slight hyperfunction in the ovary at the 10th day after discontinuation of this balneal treatment. 5) A certain correlation was found between cholinesterase activity in the brain of rat and counts of PAS positive cells in the anterior pituitary (on the sexual zone named by Purves, H. D and W. E. Griesbach). Both the activity and the counts decreased at the 10th day after onset of the balneal treatment at the temperature of 42°C for 5 minutes per single course twice daily, and then increased at the 20th day after onset of this treatment. It was also demonstrated that both the activity and the counts decreased significantly at the 10th day after onset of the balneal treatment at 42°C for 10 minutes per single course four times daily, and then increased remarkably at the 10th day after discontinuation of this treatment. 6) A negative correlation was demonstrated between changes of cholesterol levels in ovary and those of cholinesterase activity in brain. Both the levels and the activity increased transitorily at the 10th day after the balneal treatment at 42°C for 5 minutes per single course, and then decreased at the 20th day after onset of the treatment. It was also demonstrated that both the activity and the levels increased at the 10th day after onset of the treatment at 42°C for 10 minutes per single course four times daily, and then decreased after discontinuation of this treatment. From the results mentioned above the following deduction may be drawn: (a) Sexual function is affected apparently by balneal treatment; (b) As to the mode of action of balneal water on sexual function, it is likely that balneal water acts extensively on autonomic nervous system, followed by producing changes in sexual function. In the other words, it seems that balneal water primarily affects on upper central nervous system, i. e. diencephalo-hypophyseo-system, and secondarily produces changes in sexual gland; (c) It was also demonstrated that though a transitory depression in sexual function appeared individually in some subjects which were treated with extensive stimulative balneal water or over time of balneal treatment, but in even the same subjects hyperfunction often appeared after discontinuation of such a treatment. These evidence should be taken into consideration in case of clinical balneotherapy; (d) In view point that the balneotherapy produces changes in sexual function through acting on central nervous system, it may be suggested that balneotherapy with conventional hormon therapy could produce the most desirous effect for the treatment of fertility and insufficiency of sexual function. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1959-05 |
| 巻 | 25巻 |
| 開始ページ | 25 |
| 終了ページ | 52 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462888 |
| JaLCDOI | 10.18926/40241 |
|---|---|
| タイトル（別表記） | Clinical Studies on Anemia in Rheumatoid Arthritis (II) |
| フルテキストURL | 026_031_049.pdf |
| 著者 | 山本 泰久| |
| 抄録 | II. Iron Metabolism 1. The serum iron: The serum iron was estimated by the method of Umemoto and Yamamoto (by means of o-nitroso resorcinmonomethylether) The average serum iron level of 33 cases with rheumatoid arthritis was 47γ/100 ml., and in 27 of 33 cases (82%) the serum iron levels were shown to be below the lower limit of the normal range (5% rejection limit: 54-141γ/100 ml. ), but the concentrations of serum iron of neuralgias (degenerative Spondylosis, sciatica and painful shoulder) were mostly within the normal range. 2. Iron absorption: To investigate the possible role of poor absorption in preventing a response to oral iron therapy, the changes in serum iron were followed after a test of iron by mouth in 16 caseS with rheumatoid arthritis. The test dose was 1 gm. of reduced iron given with 30 mI. of lemonade-pepsin solution to preserve the iron in the ferrous state and obviate the effects of possible achlorhydria in rheumatoid patients. The results may be grouped under three headings: a) Large rise in serum iron: good adsorption. Three caseS (19%) showed a very large rise in serum iron after the test dose, which is similar to simple iron-deficiency anemia. b) Slight rise in serum iron: presumed poor absorption. Six cases (38%) showed a very small or negligible rise after the test dose, so that at its peak the serum iron was below the normal range. c) In the remaining 7 cases, a maximal rise in serum iron after the test dose was within the normal range. 3. The iron-binding capacity of the serum: The iron-binding capacity of the serum was estimated by means of intravenous injection of Gluferricon (Fe content: 10 mg.). The mean total iron-binding capacity of the serum in the present 13 cases with rheumatoid arthritis was 273γ/100ml., virtually the same as the normal figure (287γ /100 ml.). The degree of saturation of the iron-binding protein with iron was found to lie between 18 and 45% (average: 34%) in control sUbjects and between 7 and 24% (average: 16%) in rheumatoid patients. 4. The serum copper: The serum copper was estimated by means of diethyldithiocarbamate in rheumatoid arthritis with the following results. Healthy subjects: men (15 cases): mean 89.9±14.8γ /l00 ml., women (15 cases): mean 99.9± 12.6γ/100 ml. There is no significant difference between the two. In 10 of 17 cases (57%) with rheumatoid arthritis, the serum copper levels were shown to be above the upper limit of the normal range (57-138γ/100 ml. ・・・5% rejection limit), neuralgias were mostly (92%) within the normal range. The results of investigations upon alternations in iron metabolism of rheumatoid anemia are reported. 1. The serum iron concentration was usually reduced. 2. The intestinal absorption of iron after a single dose of 1 gm. of reduced iron was variable. Strong presumptive evidence of impaired absorption waS recognised in many cases, but some cases gave the excellent absorption. From these results, it seems that simple iron deficiency exist in some anemic caseS of rheumatoid arthritis. 3. The total iron-binding capacity of the serum was slightly reduced. 4. The degree of Saturation of iron-binding protein with iron was below nornal. 5. The serum copper concentration waS usually elevated. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1959-10 |
| 巻 | 26巻 |
| 開始ページ | 31 |
| 終了ページ | 49 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/40209 |
|---|---|
| タイトル（別表記） | Some Clinical Observations on the Menopausal Syndrome and its Therapeutic Approach |
| フルテキストURL | pitsr_030_046_054.pdf |
| 著者 | 熊本 寛格| |
| 抄録 | In order to observe the effectiveness of the androgen+estrogen therapy used singly or in combination with the meprobamate therapy, the author has determined the menopausal index, the total serum cholesterol and the systolic blood pressure before and after the administration of these treatments. The following results have been obtained. 1) The menopausal index (Kupperman, 1953) declines more markedly fol1owing the application of the combined therapies than after the use of either, administered singly. 2) Total serum cholesterol decreases most pronouncedly following the use of the combined therapies, to a lesser degree following the administration of A+E, still less following a single administration of meprobamate. It has been found, moreover, that although A+E therapy appreciably decreases total serum cholesterol, the effectiveness of meprobamate is slight in this respect. 3) Either therapy tends to stabilize blood pressure, but the combined treatment is more effective in this regard. It may safely be concluded that the use of these therapies singly or combined, will provide one of the most effective therapeutic approaches to the menopausal syndrome, the more especially so because of the absence of side effects, an important consideration when long term treatment, required in most such cases, is contemplated. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1962-04-25 |
| 巻 | 30巻 |
| 開始ページ | 46 |
| 終了ページ | 54 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002401090 |
| JaLCDOI | 10.18926/40205 |
|---|---|
| タイトル（別表記） | Balneological Studies of Kaike Hot Springs (I) Effect of the Internal Use of Kaike Spring Water on Gastric Acidity |
| フルテキストURL | pitsr_030_014_019.pdf |
| 著者 | 河田 義郎| |
| 抄録 | Kaike Hot Spring is situated at the seaside, in the western part of Tottori Prefecture, Japan. In chemical composition it contains 9.3 g. of salts per kilogram of spring water and may be classified as a common salt spring. The author examined the effect of the drinking of Kaike spring water on gastric acidity in 21 patients. a) Two hundred m!. of this spring water were given to 10 patients by stomach tube at 37℃. The gastric acidity of the patients was measured at 30-minute intervals for a period of 105 minutes following the administration of the spring water. In 3 cases of normal acidity and 6 cases of hyperacidiy, the spring water appeared to inhibit the secretion of gastric acid, compared with the effect of the caffein control water. b) Two hundred m!. of the spring water diluted two-fold with tap water were given to 11 patients. In two cases of normal acidity and two cases of hypoacidity, on significant difference was observed between the effects of the spring water and those of the control water. In all 7 cases of hyperacidity, however, the spring water observably depressed the acid secretion of the stomach, as compared with the effect of the control water. On the basis of these results, the author concludes that it is advisable to use the spring water diluted two-fold with tap water for the purpose of treating gastric disorders. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1962-04-25 |
| 巻 | 30巻 |
| 開始ページ | 14 |
| 終了ページ | 19 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002401087 |