検索結果 3545 件
| JaLCDOI | 10.18926/40204 |
|---|---|
| タイトル（別表記） | Effect of Radioactive Hot Spring Baths on Leukocyte Functions (Wandering Velocity and Carbon-Particle Phagocytic Ability) |
| フルテキストURL | 030_001_013.pdf |
| 著者 | 井上 正勝| |
| 抄録 | The author studied the influence of a series of radioactive hot-spring baths, lasting 20 or 30 days, upon leukocyte functions in healthy male rabbits and in patients with rhenmatoid arthritis and other diseases. The radioactive hot springs used were "Hisui-no-Yu" and "Kenkyusho-sen" (the laboratory spring), both in Misasa Spa, the chemical compositions of which are deseribed in Table 1. The following results were obtained: 1) Wandering velocity of pseudo-neutrophilic leukocytes: When a series of plain water baths (41℃., for 5 minutes daily), were administered, velocity increased after the first bathing but later remained fairly constant, compared with initial levels, except for a temporary fall on the 9th day (Fig. 3). During the administration of a series of the weakly radioactive "Kenkyushosen" baths (43℃., for 5 minutes daily), it showed a slight increase during the first week, following a temporary fall after the first bathing, and a decrease during the third week, but it tended to return to the initial level by the forth week (Fig. 1). In the course of a series of the radioactive ·Hisui-no-Yu" baths (40℃., for 10 minutes daily), it increased during the first week and tended to decrease during the second week, but returned to the initial level by the third week (Fig. 2). 2) Phagocytic ability for carbon-particles of pseudo-neutrophic leukocytes in rabbits: When plain water baths were given, phagocytic ability showed a rise on the third day, after which it declined to the initial level and remained fairly constant to the end of the observation period (Fig. 6.). On the other hand, the phagocytic ability of the leukocytes in rabbits of the groups receiving radioactive hot-spring baths increased more and more markedly as serial bathing was continued, although it had slightly decreased immediately after the first bathing. The rise of phagocytic ability in the group bathed in "Kenkyusho-sen" was especially marked on the third and ninth days of serial bathing, and also on the tenth day after serial bathing had been discontinued (Fig. 4). This tendency was also observed in the group bathed in "Hisui-no-Yu", whose phagocytic ability was noticeable especially on the third and 14th days. The degree of the rise in phagocytic ability was demonstrably high in this group than in the former (Fig. 5). Acceleration of the phagocytic function of leukocytes in rabbits was observed up to the 40th day after the series of baths in the radioactive hot spring had been concluded. 3) From these findings. it is obvious that leukocyte function is increased by repeated bathing, but it should be kept in mind that a so-called dissociation phenomenon is present between the wandering velocity and the carbon-phagocytic ability of leukocytes in the groups bathed in hot springs: namely, wandering velocity showed a tendency to decline during the third week, while carbon particle phagocytic ability showed a marked increase during the same week. 4) In order to explore the effects of a series of radioactive hot-spring baths on leukocyte functions in patients with rheumatoid arthritis or other similar diseases (for example, back pain, fibrositis or neuritis), the author examined the wandering velocity and the phagocytic ability of neutrophils, and obtained the following results: The wandering velocity of neutrophils in patients with rheumatoid arthritis or similar diseases generally showed a tendency to increase during the adminlstration of a series of the radioactive "Kenkyusho-sen" baths at a temperature of 42～43℃. (Fig. 7). The carbon-particle phagocytic ability of neutrophils gradually increase from about the seventh day onward and reached a maximum during the second week, in patients with back pain, fibrositis and neuritis (Fig. 8a). In patients with rheumatoid arthritis, however, it declined temporarily on the fifth to seventh days in 3 out of 5 patients but thereafter increased gradually, reaching its maximum on the 20th day (Fig. 8b). Thus, the leukocyte functions in patients with rheumatoid arthritis are accelerated by serial bathing, but the response in some patients may be a decline of carbon-particle phagocytic ability during the first week. This is probably due to the stress bathing imposes on adrenocortical functions. It is believed, on the basis of the facts described above, that follow-up examinations of leucocyte functions can afford a better understanding of the effects of radioactive hot springs on the defence mechanisms operative in living bodies. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1962-04-25 |
| 巻 | 30巻 |
| 開始ページ | 1 |
| 終了ページ | 13 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40213 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532380 |
| JaLCDOI | 10.18926/40198 |
|---|---|
| タイトル（別表記） | On climatology in Misasa Spa - Summary for past ten years |
| フルテキストURL | pitsr_036_031_036.pdf |
| 著者 | 的場 邦和| 八幡 隆昭| 江沢 英光| 井上 妙子| |
| 抄録 | Misasa Spa is well known as the most radioactive hot springs in Japan (maximum Rn content: 2330×10(-10) curie/l) and it has been applied to the management of neuralgia, rheumatic diseases, gastrointestinal disorders, etc. In this paper the climatological factors in Misasa Spa during the last decade (1956～1965) are summarized. The main features are as following: 1. The atmospheric temperature attains highest above 30℃ during the last ten days in July and the first ten days in August. In winter the temperature goes down below 0℃. during the last ten days in January and the first ten days in February. Owing to the high humidity, however, it is not felt so cold. 2. The amount of precipitation is more than 2,000 mm or so through the year. 3. The westwards wind is prevailing. The wind grade of 2～3 are observed most frequently. 4. Approximately 150 days of the year are clear fairly clear. 5. It is proved unexpectedly that it is rich in or the ultraviolet radiation even in winter. The results pointed above may suggest that the therapeutical period is optimal between March and October. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1966-10-25 |
| 巻 | 36巻 |
| 開始ページ | 31 |
| 終了ページ | 36 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002400934 |
| JaLCDOI | 10.18926/40197 |
|---|---|
| タイトル（別表記） | Minor elements of the Nanbu Kotai of Nakatsugo Deposits, Ningyo Toge Uranium Mine |
| フルテキストURL | pitsr_036_023_030.pdf |
| 著者 | 渡辺 晃二| |
| 抄録 | The Nakatsugo Deposits are the main deposits of the Ningyo Toge Mine which is located in the northern part of Okayama Prefecture. Nakatsugo Deposits consists of the two main ore body, namely, Nanbu Kotai (southern ore body) and Hon Kotai (main ore body). Nanbu Kotai is occupied mostly by the unoxidized zone and high grade ores containing ningyoite (n% U) are widely found in the basal conglomerates. Minor elements in the common rocks such as basal granites, conglomerates, sandstones, dikes, and shales as well as the uraniferous ores were determined quantatively by fluorescent X-ray spectrometric analysis (for U, Zr, Y, Sr, As, and Fe) and spectrophotometric analysis (for Ni and Co). As the results of this study, it is found that the uraniferous ores are characterised by extremely high contents of Zr, Y, Sr, and As, which show positive and linear correlation with the U contents. It is confirmed that As is concentrated in pyrite which is usually associated with the uraniferous ores. Elements such as Ni and Co are slightly concentrated both in the uraniferous ores and andesite dikes. This fact may suggest some genetic relationship among them. However, it does not seem to be plausible to draw any definite conclusion on the origin of the uranium deposits from these relationships. As to the minor element distribution in common rocks, no systematic variation was found except for the rock samples closely associated with the ore deposits. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1966-10-25 |
| 巻 | 36巻 |
| 開始ページ | 23 |
| 終了ページ | 30 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002400933 |
| JaLCDOI | 10.18926/40178 |
|---|---|
| タイトル（別表記） | Study on effects of balneotherapy on blood pH, P(CO(2)) and P(O(2)) Part 2. Relationships between the physiopathological factors and blood pH, P(CO(2)) and P(O(2)) |
| フルテキストURL | 038_011_025.pdf |
| 著者 | 八幡 隆昭| |
| 抄録 | From the factors which are considered to make an effect on circulatory or metabolic states, hemoglobin content, erythrocyte sedimentation rate, room temperature, respiratory rate and pulse rate were chosen to be discussed their relationships between the pH, P(CO(2)) and P(O(2)). Moreover, changes due to age and disease as well as diurnal and seasonal variations of blood pH, P(CO(2) and P(O(2)) were evaluated. 1) Blood pH and Peo2 showed the tendency of reduction in the order of 40~59, 10~39 and 60~79 years age group in the former and in the latter 40~59, 60~79 and 10~39 years age group. The P(O(2)) value in the afternoon decreased with ageing. However, no significance was demonstrated in any age group. 2) Diurnal changes of pH in 10~59 age group was very small. In the 60~79 age group, the afternoon value decreased than the morning one. The P(O(2)) value in the 10~59 age group increased in the afternoon contrasted to the decreasement in the 60~79 age group. The P(CO(2)) variations in all age groups were within the errors due to the measurement. 3) Rheumatiod arthritics group showed no significant diurnal variation different from non-rheumatoid arthritics group. 4) Blood pH of December-February group showed the lowest seasonal value and significant difference between March - May and September - November group. No significant seasonal variation was observed in the blood P(CO(2)) and P(O(2)). 5) The central nervous system group showed the significant lower blood pH than cardiovascular disease and rheumatoid arthritis group. The P(CO(2)) values of rheumatoid arthritis group were lower significantly than cardiovascular disease, central nervous system, and musculo- keletal system patient groups. None of diseases showed significant P02 difference each other. 6) Significant relationship was demonstrated between erythrocyte sedimentation rate and P(O(2)) value only in cardiovascular disease patient group. 7) There were the significant relationships between room temperature and P(O(2)) in rheumatoid arthritis and metabolic disease groups. 8) Significant relationships were shown between respiratory rate and pH in rheumatoid arthritis and cardiovascular disease groups. 9) There was significant relationship between pulse rate and pH only in rheumatoid arthritis groups. 10) The combination of the blood pH, P(CO(2)) and P(O(2)), values was shown to reflect the circuratory or metabolic states of the tissues or organs and to remain stable on the experimental day. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1969-03-20 |
| 巻 | 38巻 |
| 開始ページ | 11 |
| 終了ページ | 25 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532343 |
| JaLCDOI | 10.18926/40172 |
|---|---|
| タイトル（別表記） | The effect of radioaclive thermal bathing upon serum iron values |
| フルテキストURL | 039_061_075.pdf |
| 著者 | 山本 泰久| |
| 抄録 | The author investigated the effect of radioactive hot spring bathing on serum iron values. The serum iron values were measured by Umemoto-Yamamoto's method using o-nitrosoresorcin monomethylether, as a colour-developing reagent. The chemical compositions of the spring water used is as following: pH : 7.04, Rn : 38-151x10(-10)curies/l, K(+) : 14.0, Na(+) : 540.2, Ca(++) : 61. 2, Mg(++) : 6.6, Fe(++) : 89.0, AI(+++) : 0.1, Cl(-) : 709.5, S0(4)(--) : 179.5, HCO(3)(-) : 226.7, H(2)SiO(3) : 89.0, HBO(2) : +, CO(2) : 29.5, totaling 1,827mg/kg. 1) Single bathing: The iron values in the serum were measured before and after 0, 1/2, 1 and 2 hours after the radioactive thermal bathing for 10 minutes in water of 41 ±2℃ in temperature. Single thermal bathing showed no significant effect on the serum iron values in healthy hnman subjects, but the serum iron concent:'ations in healthy white rabbits tended to decrease following single thermal bathing and to remain at a decreased level for 1/2 to 1 hour, and returned to normally within 2 hours from the time of the bathing (Table 1, 2 and Fig. 1, 2). 2) A series of baths: The author examined the serum iron values of patients with rheumatic disorders before and 3rd, 7th, 14th, 21st and 28th days after in the course of "a series of baths" in radioactive hot spring. Patients bathed in water of 41 ± 2℃ in temperature, for 5-10 minutes, 2 or 3 times daily. A fall in the serum iron values was seen on the 3rd to 7th days. At that time the pattern of iron absorption from intestine showed a iron dificiency anemia type. The rate of absorption of iron was rapid. At about the 14th day, the serum iron values of patients tended to increase but unbound iron-binding capacity of the serum decreased. Subsequently, the serum iron values returned to the initial levels between the 21st and 28th day (Table 3, 4, 5, and Fig. 3, 4, 5), 3) It is said that the reticulo-endothelial system plays an inportant part in iron metabolism. The author injected 5 ml of Indian ink into the aural vein of rabbits for the purpose of blocking the reticulo-endothelial system. These procedures were carried out once a day for 7 successive days. The rabbits with "a blockade of R. E. S." had no significant change in the serum iron values during a series of baths. From what has been stated in the above, it may be said that bathing in radioactive hot springs regubtes the iron metabolism of patients with anemia and brings about the acceleration of the medullary function. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1970-03-30 |
| 巻 | 39巻 |
| 開始ページ | 61 |
| 終了ページ | 75 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532352 |
| JaLCDOI | 10.18926/40155 |
|---|---|
| タイトル（別表記） | Esophagus hiatal hernia with special reference to the early stage |
| フルテキストURL | pitsr_041_063_068.pdf |
| 著者 | 野一色 泰晴| 古元 嘉昭| 仲原 泰博| |
| 抄録 | In the aged, hiatal hernia should be recognized as it has developed; it develops progressively. Special attention should be given to the early stage of hiatal hernia from the genetic point of view. Like other organs in the aged, aging changes around a hiatus are inevitable; relaxing of esophageal diaphragmatic ligament and weakening of muscle power of diaphragmatic vertebral part move on with age. After all, valve structure at hiatus, Goubaroff's valve, is so weakened its function and in the stomach, "His angle" is so widened, that the stomach becomes wedge shaped against the hiatus. The more the pressure in the stomach increases, the larger the wedge shapes. Under these conditions, when the abdominal pressure rises by the acts of coughing or defecation, hiatus may be widened and the wedge may be pushed into the hiatus. There are no strong valve and or ligament enough to keep the wedge part of stomach in peritoneal cavity. In the stomach, the pressure of the expelling meal is equal to that of the widening wedge. On the other hand, in the peritoneal cavity, pressure produced by the act of defecation is equal to that of ejecting the wedge through hiatus. These are self-evident from the Pascal's principle. Hiatal hernia is produced under these conditions. We, therefore, should call the attention to the early genetic stage of hiatal hernia. In Japan, hiatal hernia has been recognized when it gets larger and fixes out of the peritoneal cavity. But in the early stage, it also must be noted as hiatal hernia. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1972-03-25 |
| 巻 | 41巻 |
| 開始ページ | 63 |
| 終了ページ | 68 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002398151 |
| JaLCDOI | 10.18926/40150 |
|---|---|
| タイトル（別表記） | On the measurement of oxygen and carbon isotopic ratios of carbonates |
| フルテキストURL | pitsr_041_009_012.pdf |
| 著者 | 渡辺 洵| 松葉谷 治| |
| 抄録 | Oxygen and carbon isotopic ratios of two working standards of our laboratory and three other standards were measured by McCrea's technique and the new McKINNEY type mass spectrometer in this Institute. The reproducibility of δ(13)C measurement is about ±0.2‰. Some systematic differences in δ(18)O values were observed among the three measurements in Apr.-May, July, and Aug., 1971. Because these systematic differences are supposed to be caused by the imperfection in the processes of decomposition of carbonates by phosphoric acid, the reproducibility of δ(18)O measurement may be ±O.2‰ in most cases. The calibrations of our working standard, CK-13, against the PDB standard were carried out on the assumption that δ(18)O and δ(13)C of CK-13 are -1.75‰ and +O.54‰ relative to PDB, respectively. The accuracy of these calibrations is about ±O.2‰ as shown by the interlaboratory comparison of some standards (Table 3). The δ(18)O values of the two working standards relative to PDB are independently recalculated relative to SMOW based on the two assumptions (Table 4). One of which is that a standard water MSA-2 is -8.20‰ relative to SMOW, and the other is that the δ(18)O of CK-13 is -1.75‰ relative to PDB. The results of both calculations agree within 0.4‰. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1972-03-25 |
| 巻 | 41巻 |
| 開始ページ | 9 |
| 終了ページ | 12 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002398149 |
| JaLCDOI | 10.18926/40149 |
|---|---|
| タイトル（別表記） | A subsequent report on the new McKinney type mass spectrometer in the Institute for Thermal Spring Research, Okayama University |
| フルテキストURL | pitsr_041_003_007.pdf |
| 著者 | 松葉谷 治| |
| 抄録 | Since the installation in April 1970, the McKinney type mass spectrometer has maintained a good condition and about 5000 isotopic analyses of oxygen, carbon and sulfer has been cerried out so far. The ion source filament was changed to spiral one from single wire. Consequently three times sensitivity and the longer life of filament were obtained. Gradual changes in the ratio of potential divider (β) and the sensitivity (|△ E(0)(2)|/E(0)(1)) for the difference of β have been observed (Table 1). Because these changes are opposite in trend but similar in degree, it is supposed that these changes are caused by decrease of feed-back resister value in the balancing system. Although there remain some problems in the corrections for the difference in observed isotopic tatio between two cases that a same CO(2) is fed to ion source from the ST side of inlet system on the one hand and from the X side on the another, the reproducibility of the measurement of isotopic ratio for long period is about ±O.1‰ (Table 2, Fig. 1). δ(18)O values of standard waters, MSA-1 and MSA-2, measured during a period from May to Dec. 1970 and in Sep. 1971 yielded good agreements implying the reproducibility of the measurement to be constant (Table 3). Both calculated δ(18)O values relative to a given sample based on each observed δ(18)O value relative to two different samples agreed each other. It is concluded that the linearity of observed a-value holds over a range of 30‰ (Table 4). |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1972-03-25 |
| 巻 | 41巻 |
| 開始ページ | 3 |
| 終了ページ | 7 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002398147 |
| JaLCDOI | 10.18926/40143 |
|---|---|
| タイトル（別表記） | Rheumatoid arthritis and Sjögren's syndrome |
| フルテキストURL | 042_031_045.pdf |
| 著者 | 市川 幸延| |
| 抄録 | 1. Parotid Sialography Parotid sialograms were investigated in 29 patients with classical or definite RA according to the criteria of the American Rheumatism Association (one of whom had scleroderma), 5 patients with SLE (according to the Dubois's criteria, three were definite, one probable and another possible SLE), 3 patients with other autoimmune diseases (Hashimoto's thyroiditis, colitis ulcerosa and undiagnosed collagen disease), 3 patients with polyarthralgia and 10 patients with nonautoimmune diseases. Sialographic technique was performed by modified Rubin's Method using contrast medium Conray-400. Sialectasis which is pathognomonic of Sjögren's syndrome (SS) alone was observed in 6 patients with RA (20.7%) (3 punctate and 3 globular patterns) and 2 patients with SLE (one punctate and another globular pattern). Retention of the contrast medium in the duct for at least 5 minutes after the injection was observed in patients with RA, one patient with SLE and one patient with colitis ulcerosa. Sial ectasis and retention almost always existed together, and were observed in patients from young to older one. Although dilatation of the Stensen's duct and subalveolar dissection also existed together, they were observed in only older patients. It appeared that the former is the specific findings of SS and the latter is the non-specific findings according to the aging. Dry mouth was complained in 7 sialectasis (87.5%), 3 subalveolar dissection (60.0%), 10 retention (62.5%) and 9 normal sialogram (37.5%). Salivary hyposecretion (less than 10 ml/10min) was observed in 4 sialectasis (50%), one subalveolar dissection (20%), 6 dilatation of the Stensen's duct (37.5%), 5 retention (45.5%) and one normal sialogram (4.2%). These results show that sialectasis and retention are well correlated with salivary hyposecretion, but dry mouth is not so diagnostic in SS. Two patients with SLE had sialectasis were young women and showed normal salivary and lacrimal secretion. These cases may be supported by Heaton's hypothesis that SS is a benign and chronic form of SLE, or thay may be a subclinical state of SS. 2. Schirmer test Sixty seven patients (36RA, 6SLE, 3 other autoimmune diseases, 3 polyarthralgia and 19 non-autoimmune diseases) were examined by Schirmer test. Besides lacrimal hyposecretion was observed in RA and other autoimmune diseases, it began in younger age. These results show that autoimmune diseases have a sicca element in themselves. Compared with the results of sialography, Schirmer test was not correlated with sialectasis and retention. Dry eye was complained in only 4 patients (13.3%) with lacrimal hyposecretion (less than 10mm/5min) and all patients with dry eye had keratoconjunctivitis sicca (KCS). Dry eye is more diagnostic than Schirmer test. 3. Corneal staining by 1% rose bengal solution Twenty five patients with RA or SLE were examned corneal staining (Holm's type A) was observed in 5 patients with RA (20%). Staining of the medial and lateral bulbar conjunctiva (Holm's type B and C) were observed in 6 patients with RA (24%) and one patient with SLE. Nine patients with positive staining (type A, B and C) (75%) showed lacrimal hyposecretion. Dry eye was complained in 4 patients with type A staining (80%), but no patient with type B and C complained dry eye. Dry eye appears to be specific for the diagnosis of SS as sialectasis on the sialogram. 4. Salivary secretion All amount of saliva was collected during ten minutes chewing two pieces of gum. All of 21 patients with non-autoimmune diseases showed more than 10 ml/10min, and slight degree of salivary hyposecretion was observed with aging. Nine patients with RA (25.7%) showed salivary hyposecretion (less than 10ml/10min), besides it began in younger age. It was also observed in patients with other autoimmune diseases. Only 36.4% patients with salivary hyposecretion showed sialectasis on the sialogram. It can be supposed that patients with sialectasis and good salivary secretion are subclinical states of SS, and that this state is depends on the compensative function of the glands. Therefore, it is impossible to suppose the salivary dysfunction from the complaints of patients alone. It is required that saliva must be analysed not only quantitativly but also qualitativly (such as RA factor, complement and lysozome). Dry mouth was not only complained in 9 patients who showed salivary hyposecretion (81.8%). but in 10 patients showed normal secretion (50%). Dry mouth appears to be less specific for the diagnosis of SS than dry eye. 5. Diagnosis of SS Vanslow's criteria of SS was modified as follows. (1) Major : ① Sialectasis or salivary gland enlargement ② Positive corneal staining (type A) ③ Classical or definite RA (according to the criteria of the ARA) (2) Minor : ① Arthritis ② History ot salivary gland swelling ③ Dry mouth or salivary hyposecretion (less than 10ml/10min) ④ Dry eye or positive Schirmer test (less than 10mm/5min). Three major was diagnosed as definite, 2 major as probable and one major with one or more minor as possible SS. Of 35 patients with RA, definite (8.6%), probable (17.1%) and possible SS (54.3%) were obserevd. Two of SLE (33.3%) were possible SS. One patients with undiagnosed collagen disease was possible SS. Clinically, definite and probable SS may be diagnosed as Sjögren's syndrome. Two possible SS with SLE may be supporsed as subclinical states of SS who do not yet exhibite full criteria. Compared with the clinical and laboratory findings of these definite, probable and possible SS with RA, it was supporsed that positive antinuclear factor or positive LE cells in RA patients almost always represents SS, drug allergy, especially to gold therapy may be a manifestation of SS. Hypergammaglobulinemia, extreme elevation of erythrocyte sedimentation rate, struma, lymphnode enlargement in RA patients must be suspected of SS. Although one possible SS with SLE and one probable SS with RA showed positive ANF (peripheral pattern), it is impossible to differentiate SS from SLE by ANF alone. Because Suzuki et al. reported that 15.4% of SS had showed positive ANF (peripheral pattern). Examinations of salivary glands including sialography must be performed in patients with SLE in the future. To detect a subclinical SS, sialography and corneal staining must be performed even in patients with no sicca symptom, because of the compensatory functions of salivary and lacrimal glands. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1973-03-25 |
| 巻 | 42巻 |
| 開始ページ | 31 |
| 終了ページ | 45 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532309 |
| JaLCDOI | 10.18926/40136 |
|---|---|
| タイトル（別表記） | Oxygen Isotopic Composition of Water in the Living Things : Preliminary Analyses and Discussions |
| フルテキストURL | pitsr_044_061_075.pdf |
| 著者 | 木島 宣明| |
| 抄録 | Oxygen isotope analysis was carried out, by use of a new method (oxalate equilibration method) of preparing CO(2) for mass spectrometry, on water samples extracted from a number of biological samples collected in Misasa Town and Hashizu Coast, Tottori Prefecture. The δ values (the per mil enrichment of (18)O in sample waters relative to the Standard Mean Ocean Water) were suggested to be distributed in the living things as follows. The water absorbed by plant roots was supposed to have the same δ value with the water outside it (δs. about -8‰), and in a rapidly transpiring plant, this water reached the leaves, partly infiltrating into the phloem. When transpiration was slow, on the other hand, the isotopic composition of ascending xylem sap was modified by the exchange of water with phloem. where leaf water with a higher δ value was migrating. As Gonfiantini et aI. (1965) and Dongmann et al. (1972) have odserved, leaf waters were enriched markedly in (18)O in the daytime. A criterion of the δ of leaf water may be the sum of δs and △δ that corresponds to the (18)O fractionation factor in the H(2)O(I)-H(2)O(v) system. The sum comes to about 0‰ at ordinary leaf temperatures. and really δ values near 0‰ were observed in leaves of some herbaceous plants, in exudate from a tip of vine of Kudzu, in body fluid of herbivorous insects, etc., but higher δs (up to +19‰) were also observed in some other leaves such as pine needles, Especially leaves showed an increase in δ by about 10 ‰ toward the pnd of November when the average temperature fell below 10℃, probably because of accumulation of the daily enrichment as a resul t of slow water absorption and circulation. A few plant species grown on a dune were analyzed and it seemed that, among them, herbaceous plants were dependent on spraied sea water and pine trees on ground water. δ's of petal water were dispersed (-9～-3‰), probably according to the volume-to-transpirational flux ratio of water in the petals. Succurent fruits in enlarging stage seemed to have lower δ's near δs, but in maturing stagp δ's increaspd to about -4‰, i.e., to the avpraged δ of Ieaf water in the day and night. Herbivorous insects (imagines and la rvae) in general had distinctly higher δ values than carnivorous insects, the border being at -1‰. However, lower δ's at about -5‰ were obserbed on aphides which might have been sucking somewhat dilutpd leaf water from seave tube cells. Sometimes the δ of a herbivorous insect was a few per mil higher than that of the leaf it was nibbling, probably as a result of evaporation of water from the insect and of respiration. The level at about -3‰ common for carnivorous insects could not be explained, although tipula and chironomus making a swarm also showed a δ value on the level. Blood of a heron did not show such a low δ as supposed from its food habit. As compared with the drinking water of -8‰, blood and urine were found to have an identical δ in the range of -4 to -5‰ in either mouse or man, The δ value of the oxidation water produced in man's body was estimated to be about -6‰ from an approximate water balance. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1975-03-25 |
| 巻 | 44巻 |
| 開始ページ | 61 |
| 終了ページ | 75 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002383784 |
| JaLCDOI | 10.18926/AMO/40133 |
|---|---|
| フルテキストURL | 64_4_249.pdf |
| 著者 | Masumoto, Akio| Masuyama, Hisashi| Takamoto, Norio| Akahori, Yoichiro| Hiramatsu, Yuji| |
| 抄録 | It has been reported that prolactin (PRL) is cleaved to 14 or 16 kDa fragments by cathepsin D in vitro and in vivo, and that such fragments exhibit antiangiogenic and proapoptotic properties. The aim of this study was to investigate the relationship between pregnancy induced hypertension (PIH) and the placental expression of antiangiogenic PRL fragments and cathepsin D. Placental expression of PRL fragments and cathepsin D was evaluated by Western blot analysis in a group of 9 pregnant women consisting of 5 normal pregnancies and 4 severe PIH cases. Antiangiogenic PRL fragments were detected in 4 placental samples from all PIH cases but not detected in those from normal pregnancies (p0.05). The expression of cathepsin D in PIH placentas was significantly lower than that in those without PIH (p0.05), while the placental expression of procathepsin D was significantly greater in PIH cases than in the normal pregnancies (p0.05). These data suggest that antiangiogenic PRL fragments in the placenta may be present only in PIH cases, and that PRL fragments in the placenta might be implicated in the pathophysiology of PIH. |
| キーワード | pregnancy induced hypertension preeclampsia prolactin prolactin fragment cathepsin-D |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 249 |
| 終了ページ | 255 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802542 |
| Web of Science KeyUT | 000281384400006 |
| JaLCDOI | 10.18926/AMO/40132 |
|---|---|
| フルテキストURL | 64_4_243.pdf |
| 著者 | Myo-Khin| Myat-Tin-Htwe-Kyaw| Yi-Yi-Kyaw| Ohmar-Lwin| Myat-Phone-Kyaw| Khin-May-Oo| Shimono, Kunio| Koide, Norio| Okada, Shigeru| |
| 抄録 | The efficacy of AntiOxidant Biofactor (AOB(R)) for the management of apparently healthy subjects with chronic hepatitis C infection was investigated. A total of 60 subjects (35 males, 25 females) participated in the trial. AOB was given orally in 2 packs (3g per pack) 3 times per day. 17 subjects had taken AOB for 3 years, 31 subjects up to 2 years, and 41 subjects up to one year. The initial mean (SD) serum alamine aminotransferase (ALT) level was 46.3+/-35.4IU/L, and significant (p0.05, paired t-test) reductions in the mean serum ALT levels were observed at 6 months (38.6+/-21.5IU/L), 18 months (31.9+/-18.1IU/L), 2 years (31.2+/-14.6IU/L), and 3 years (28.0+/-15.9IU/L). Those presenting with high serum ALT levels (30 subjects) demonstrated significant levels (p0.05, paired t-test) of reduction in the mean serum ALT levels at 6, 12, 18, 24, and 36 months of treatment. No side effects were observed and the AOB treatment was well tolerated by all subjects. |
| キーワード | hepatitis C AntiOxidant Biofactor (AOB®) ALT level |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 243 |
| 終了ページ | 248 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802541 |
| Web of Science KeyUT | 000281384400005 |
| JaLCDOI | 10.18926/AMO/40128 |
|---|---|
| フルテキストURL | 64_4_213.pdf |
| 著者 | Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Makino, Hirofumi| |
| 抄録 | Aldosterone production occurs in the adrenal cortex, and is regulated primarily by angiotensin II (Ang II), potassium and adrenocorticotropin (ACTH). In the presence of the aldosterone stimulators, steroidogenesis is further governed by local autocrine and/or paracrine factors in the adrenal cortex. We reported the presence of functional bone morphogenetic protein (BMP) system in the adrenal cortex and also demonstrated that BMP-6 increases Ang II-induced aldosterone production, which could be involved in the "aldosterone breakthrough" phenomenon. Aldosterone breakthrough is the phenomenon by which circulating aldosterone concentrations increase above pre-treatment levels after long-term therapy with ACE inhibitors or Ang II type 1 receptor antagonists (ARB). This phenomenon may lead to important clinical consequences since increased aldosterone in a high-salt state facilitates cardiovascular and renal damage in hypertensive patients. We found that long-term ARB treatment reverses the reduction of aldosterone synthesis by adrenocortical cells, thereby causing "cellular aldosterone breakthrough". The availability of BMP-6 in the adrenal cortex may be at least partly involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB. |
| キーワード | adrenal cortex angiotensin II aldosterone bone morphogenetic protein |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-08 |
| 巻 | 64巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 213 |
| 終了ページ | 218 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20802537 |
| Web of Science KeyUT | 000281384400001 |
| 著者 | 濱野 亮輔| 稲垣 優| 西江 学| 徳永 尚之| 常光 洋輔| 大塚 眞哉| 岩川 和秀| 岩垣 博巳| 園部 宏| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 永坂 岳司| 田中 紀章| 孫 冬生| 猶本 良夫| 松原 長秀| 八木 孝仁| 藤原 俊義| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/40013 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
| 抄録 | We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and metabolic syndrome in Japanese. A total of 11,711 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation. From this group, we further investigated the data on 1,576 subjects. eGFR was calculated using serum creatinine (Cr), age and sex. The diagnosis of metabolic syndrome was based on the Japanese criteria. In the first analysis, 288 men (7.8%) and 498 women (6.2%) were diagnosed with reduced eGFR (<60ml/min). eGFR was not correlated with anthropometric, body composition parameters in either sex. In the second analysis, in subjects without medications, 132 men (20.8%) and 15 women (1.6%) were diagnosed with metabolic syndrome. eGFR was lower in men with abdominal obesity and in women with hypertension was than in those without. Among Japanese not taking medications, lower eGFR may be a characteristic of men with abdominal obesity and of women with hypertension. |
| キーワード | metabolic syndrome estimated glomerular filtration rate (eGFR) abdominal circumference |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2010-06 |
| 巻 | 64巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 203 |
| 終了ページ | 208 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20596132 |
| Web of Science KeyUT | 000279094300007 |
| 著者 | Higashi, Kuniaki| Ishiga, Yasuhiro| Inagaki, Yoshishige| Toyoda, Kazuhiro| Shiraishi, Tomonori| Ichinose, Yuki| |
|---|---|
| 発行日 | 2008-03-01 |
| 出版物タイトル | Molecular Genetics and Genomics |
| 巻 | 279巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Toyoshima, Megumi| Hosoda, Kanako| Hanamura, Miho| Okamoto, Keinosuke| Kobayashi, Hiroshi| Negishi, Tomoe| |
|---|---|
| 発行日 | 2003-11 |
| 出版物タイトル | Journal of Photochemistry and Photobiology B: Biology |
| 巻 | 73巻 |
| 号 | 1-2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Teraishi, Fuminori| Kagawa, Shunsuke| Watanabe, Takanori| Tango, Yasuhisa| Kawashima, Takeshi| Umeoka, Tatsuo| Nisizaki, Masahiko| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| 発行日 | 2005-08-01 |
| 出版物タイトル | FEBS Letters |
| 巻 | 579巻 |
| 号 | 19号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Morimoto, Riyo| Uehara, Shunsuke| Yatsushiro, Shouki| Juge, Narinobu| Hua, Zhaolin| Senoh, Shigenori| Echigo, Noriko| Hayashi, Mitsuko| Mizoguchi, Toshihide| Ninomiya, Tadashi| Udagawa, Nobuyuki| Omote, Hiroshi| Yamamoto, Akitsugu| Edwards, Robert H| Moriyama, Yoshinori| |
|---|---|
| 発行日 | 2006-09-20 |
| 出版物タイトル | EMBO Journal |
| 巻 | 25巻 |
| 号 | 18号 |
| 資料タイプ | 学術雑誌論文 |