| JaLCDOI | 10.18926/40322 |
|---|---|
| タイトル（別表記） | THE CLINICAL STUDIES OF RHEUMATOID ARTHRITIS (I) |
| フルテキストURL | 016_035_048.pdf |
| 著者 | 森永 寛| |
| 抄録 | The value of spa treatment of rheumatic disease is an established feature of medical management based on experiences for many centuries. The author has been practising the balneotherapy of rheumatic diseases at Misasa Spa for several years, and has found this therapy efficacious in many cases in relieving the anemia that accompanies rheumatoid arthritis. For this reason, the author is investigating the metabolism of iron in rheumatic anemia, which is expected to occur in the course of the spa treatment. In this report, the results of clinical examinations of 24 patients with rheumatoid arthritis, of the type (2. 2. 2.) Polyarthritis systemica chronica (in Prof. Kodama's classification of arthritis), are described. I. Some observations of anemia in rheumatoid arthritis 1. The peripheral blood The number of erythrocytes is 266×10(4)～455×10(4)/c. mm. (average: (381±32)×10(4)/c. mm.), Hb-content : 55～90% (average : 76±5.8%), and the color index is about 1.0. The anemia of rheumatic disease treated is mostly normochromic. The white blood count is between 3240 and 13300/c. mm. (average: 6421±955/c. mm. ), and the number of the leucocytes in 80% of the cases ranges within the normal limits. Eosinophilia is observed in 15% of the cases. 2. Anemia-producing substance in the serum of rheumatoid arthritis When serum from rheumatoid arthritis patients was injected into rabbits, the number of erythrocytes and the hemoglobin -content of the rabbits was found to decrease markedly for 2～6hours after the injection. But no such effect was observed when the serum of healthy subjects was injected. From this, the author presumes the presence of an anemia-producing substance in the serum of rheumatoid arthritis. The nature of this substance in now under investigation. II. Clinical-biochemical studies 3. Gastric acidity of rheumatic patients Of 7 cases examined, anacidity of gastric juice was observed in 2 cases, subacidity in other 2 cases and normacidity in the remaining 3 cases. Thus, a decrease in the gastric acidity was found to occur in 57% of the cases. 4. Takata-serum-test and sedimentation rate It is said that the sedimentation rate and the Weltmann-reaction are very sensitive indicators of the extent of the activity of rheumatic disease. The Takata-serum-test was applied in 18 cases and was found to give positive results in 10 cases (55%). The sedimentation rate was found to increase in 17 of 20 cases (85%). 5. Blood uric acid As is well known, the concentration of uric acid is abnormally high in the blood of patients with gout; while, according to the literature, the blood uric acid levels of patients with rheumatoid arthritis range within the normal limits. The author, using the method of Benedict, obtained the following results for blood uric acid in 14 normal subjects in fasting state: Range - 2.30～3.47mg./dl. , 5% rejection limit -- 1.97～3.68mg./dl. In 5 of 7 cases of rheumatoid arthritis, the blood uric acid levels were shown to be above the upper limit of the normal range, but the concentrations of blood uric acid of non-rheumatic joint diseases and neuralgias were mostly within the normal range. 6. Blood sugar The fasting blood sugar levels of rheumatoid patients ranged from 82 to 1l0mg./dl. (average : 100mg./dl.), higher than the levels of healthy subjects (78～108mg./dl., average : 90mg./dl.). The intravenously injected glucose load test was applied to 8 rheumatoid patients. A solution of 40 ml. of 20% glucose was injected into a fasting subject for 2 minutes. Blood samples were taken before the injection, 3 minutes after the injection, and at each subsequent 10 minute-interval for 70 minutes. The glucose tolerance curves in 5 of these cases were found to be out of the normal range. It is to be noticed that the average blood sugar for rheumatoid arthritis is similar to the curve for liver disease. 7. Serum alkaline phosphatase activity and serum phosphorus The method of Taussky-Shorr was used for the determination of the level of alkaline phosphatase activity and inorganic phosphate in the serum. The alkaline phosphatase activity of 11 normal individuals ranged from 1.4 to 6.4 Shinowara-Jones-Rheinhart units/dl. (5% rejection limit), while in 4 of 8 cases of rheumatoid arthritis, it was of abnormally high levels. The concentration of inorganic phosphate in the serum of 12 normal subjects ranged from 2.9 to 5.0mg. /dl. (5% rejection limit), while in 3 cases of rheumatoid patients, it showed higher levels than normal. 8. Total cholesterol in serum The total cholesterol in the serum of fasting normal individuals was measured by Bloor's method, and the concentration was found to range from 124 to 188mg./dl. (rejection limit of 5% level of significance), and the total cholesterol in the serum of rheumatoid arthritis to be abnormally high in concentration in 6 of 7 cases. The liver function was evaluated by the Takata-serum-test, the test of fasting blood sugar levels, the glucose load test, and the test of serum alkaline phosphatase activity; and from this the hepatic dysfunction was found to occur in rheumatoid arthritis patients in about 50% of the cases examined. Disturbances in the protein, fat, and carbohydrate metabolism were also found to occur. The above-mentioned findings indicate that rheumatoid arthritis is not only a disease of the joints, but also a general and systemic illness. Attention must accordingly be given to the general condition of the patient in the treatment of rheumatic disease. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1956-01 |
| 巻 | 16巻 |
| 開始ページ | 35 |
| 終了ページ | 48 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40318 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532470 |
| JaLCDOI | 10.18926/40321 |
|---|---|
| タイトル（別表記） | SEASONAL VARIATION OF GASTRIC ACIDITY |
| フルテキストURL | pitsr_016_031_034.pdf |
| 著者 | 森永 寛| |
| 抄録 | Since, in Japan situated in the temperate zone, climatic change through the four seasons of a year is regular, it is expected that there the physiological reactions of the human body may vary regularly in accordance with the climatic change. In fact, we experience that the attacks of diseases and their conditions are in close connection with the changes of the seasons. The author investigated the effect of the seasons upon the human gastric acidity, by means of the coffein-test, in 580 cases with gastrointestinal disorders, at the Misasa Branch Hospital of Okayama University, Misasa Spa in Tottori Prefecture, in 1946～1946. Hyperacidity was verified in 194 (33%) of 580 cases, normacidity in 134 (23%), anacidity in 138 (24%) and hypacidity in 114 (20%). The percentage of hyperacidity increases in winter (41%), decreases in spring (32%) and in summer (28%), and increases again in autumn (34%). The cases of anacidity decrease in winter and spring, but increase in summer. In chi-square test, the season and the acidity of gastric juice were taken as factors of variation. The chi-square was computed with the result: Pr {X(3)=14.013<16.919} =5%, so it cannot be asserted that the seasonal changes effect the acidity of gastric juice. But if Comparison is made between summer and winter with respect to the anacidity-hypacidity vs. the hyperacidity, the author: obtains Pr {X(2)=6.06> 5.412} =2%. It is thus verified that the cases of hyperacidity predominate over those of anacidity-hypacidity in winter, while the relation is reverse in summer. As was mentioned above, the tendency is obvious that the acidity of gastric juice decreases in summer and increases in winter. It was found that there is a regular seasonal variation in gastric acidity. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1956-01 |
| 巻 | 16巻 |
| 開始ページ | 31 |
| 終了ページ | 34 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40318 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462901 |
| JaLCDOI | 10.18926/40320 |
|---|---|
| タイトル（別表記） | ANEMIA-PRODUCING SUBSTANCE IN RHEUMATOID ARTHRITIS |
| フルテキストURL | pitsr_016_019_030.pdf |
| 著者 | 岸田 専蔵| |
| 抄録 | The anemia that usually accompanies rheumatoid arthritis has been thought to be caused by an infection of unknown etiology. The author found from his experiment that a temporary anemia is caused in rabbits by the injection of the serum of patients with rheumatoid arthritis into them, but no such effect by the injection of the serum of healthy subjects. The author presumes the existance of an anemia-producing substance in the serum of the rheumatoid arthritis. The nature of this substance is now under investigation. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1956-01 |
| 巻 | 16巻 |
| 開始ページ | 19 |
| 終了ページ | 30 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40318 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462900 |
| JaLCDOI | 10.18926/40319 |
|---|---|
| タイトル（別表記） | REPORT OF THE CHEMICAL ANALYSIS OF MISASA HOT SPRINGS, TOTTORI PREFECTURE |
| フルテキストURL | 016_001_018.pdf |
| 著者 | 大島 良雄| 御船 政明| 山田 尚春| 上山 昭子| |
| 抄録 | The water samples of 55 springs of Misasa were analysed in the years 1950～1951. The temperatures of the waters ranged from 44° to 85° C. Radon content ranged from 34.1 to 2360×10(-10) curies per liter. pH 6.2～7.5. Evaporation residue: 534～1940 mg/kg. K(+) :10.4～47.3mg/kg. Na(+) : 140.4～574mg/kg. Ca(2+) : 7.56～49.06mg/kg. Mg(2+) : 0.11～15.3mg/kg.. Fe(2+) : 0.10～0.67mg/kg. Cl(-) : 138～854mg/kg. SO(4)(2-) : 29.2～187mg/kg. HCO(3)(-) : 74.8～370mg/kg. HBO(2)(-) : 1.80～19.6mg/kg. S(2)O(3)(2-) : o.62～3.69mg/kg. Radon sources seem to exist at shallow places under the ground and the radon in the thermal wacer is supposed to have been derive partly from the ground water which also contains considerable amount of radon. A close linear correlation (r=0.751) was proved between the sulfate and the chloride ion contents. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1956-01 |
| 巻 | 16巻 |
| 開始ページ | 1 |
| 終了ページ | 18 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40318 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532473 |
| JaLCDOI | 10.18926/40316 |
|---|---|
| タイトル（別表記） | THREE CASE OF LAMBLIASIS INTESTINALIS |
| フルテキストURL | 017_033_041.pdf |
| 著者 | 松本 欣之| 信岡 於兎彦| |
| 抄録 | We experienced three cases of patients with Lambliasis intesinalis recently. and described their clinical features in detail. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1956-03 |
| 巻 | 17巻 |
| 開始ページ | 33 |
| 終了ページ | 41 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40311 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532475 |
| JaLCDOI | 10.18926/40315 |
|---|---|
| タイトル（別表記） | OUR EXPERIENCES OF INTRAARTICULAR HYDROCORTISONE INJECTION AND SPA TREATMENT FOR RHEUMATOID ARTHRITIS AND ARTHROSISDEFORMANS |
| フルテキストURL | 017_019_032.pdf |
| 著者 | 仲原 泰博| 泉 友圀| |
| 抄録 | 1. We classified 89 cases of rheumatoid arthritis and arthrosis deformans according to Prof. T. Kodama's criteria as follows: 33 cases of (222) polyarthritis systemica (37%), 15 cases of (221) polyarthritis non systemica (16.8%) 22 cases of (111) monoarthrosis non systemica (24%), and others. 2. We analysed their symptoms following the criteria recommended by the New York Rheumatism Association and Prof. T. Kodama. In many cases of (222), their local and general symptoms were found to belong to Class III or IV, and in many cases of (111) and (221), to Class I or II. This shows that (222), here treated, was severer than (111) and (221) in both local and general conditions. The hepatic disorder and anemia were found to occur in patients with (222). 3. We treated these 89 cases chiefly by spa therapy and intraarticular injection of hydrocortisune, and evaluated the results by the criteria recommended by N. Y. R. A. and Prot. T. Kodama. Each of these treatments was more effective on (111), (121), and (221) than on (222). In all cases, the combined treatment with the said two measures was more efficacious than the separate treatment with each of the two. 4. The effects of the intraarticular hydrocortisone injections, 686 in total and mostly into knee joints, were examined. The most efficacious of these were obtained when the injection was made into fingers, toes or hip joints. In our experiences, the post-injection flare ups and the adverse effects of the treatments were observed in 2.8% of the cases treated, but they lasted only for a few days. 5. Of five cases of (222), where the combined treatment of hydrocortisone intraarticular injection and spa therapy was given for 5-14 months, detailed descriptions are given. By this treatment the physical abilities in joints of patients were improved remarkably and their general conditions were ameliorated gradually without any adverse effects. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1956-03 |
| 巻 | 17巻 |
| 開始ページ | 19 |
| 終了ページ | 32 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40311 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532476 |
| JaLCDOI | 10.18926/40314 |
|---|---|
| タイトル（別表記） | BALNEOTHERAPEUTIC EXPERIENCES IN GYNECOLOGY (6) A STATISTICAL INVESTIGATION ON CHANGE OF SUBJECTIVE SYMPTOMS OF 30 GYNECOLOGIC PATIENTS IN THE COURSE OF BALNEOTHERAPY IN MISASA SPA |
| フルテキストURL | pitsr_017_013_018.pdf |
| 著者 | 田中 良憲| 細川 隆海| |
| 抄録 | 1. The chief complaints of the patients were lower abdominal pain (33%), menstrual disorder (23%), infertility (20%), etc. 2. As disease, adnexitis (17%), retroflexio uteri (23%), vaginitis (13%), etc. were noted. 3. As balneotherapy they took thermal bath on an average 4 times a day for three weeks in Misasa radioactive spa. 4. Various "Fäder-reaktionen" were noted on 70% of the patients. They were fatigue (33%), dulling of the appetite (23%), small uterine bleeding (20%), lower abdomimal pain (17%), fever (11%), vaginal discharge (7%), etc. 5. The above-mentioned small uterine bleeding occured about 7 th day of the cure, and continued for 2 days on an average. In most cases, it was accompanied by the lower abdominal pain. 6. A temporary change of menstrual cycles after the cure was noted in 30% of the patients. 7. In 62% of the cases treated. the spa treatment gave curative effects paticularly on various pains and vegetative disharmony, but none on infertility. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1956-03 |
| 巻 | 17巻 |
| 開始ページ | 13 |
| 終了ページ | 18 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40311 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462899 |
| JaLCDOI | 10.18926/40313 |
|---|---|
| タイトル（別表記） | EFFECT OF INTERNAL USE OF THERMAL WATER OF YUMURA AND MUSASHI HOT SPRINGS UPON THE ALIMENTARY HYPERGLYCEMIA IN RABBITS |
| フルテキストURL | pitsr_017_008_012.pdf |
| 著者 | 森永 寛| |
| 抄録 | The author investigated the effect of the internal use of thermal water of Yumura (weak alkaline spring, Hyogo Prefecture) and Musashi (weak common salt spring, Fukuoka Prefecture) Springs upon the alimentary hyperglycemia in rabbits. Sixty ml. of spring water, and of plain water as control, with 10% glucose in solution was administered to rabbits by stomach tube, and the blood sugar level was determined before and 1/2, 1, 2 and 3 hours after the administration. In all cases, the thermal water was revealed to inhibit the alimentary hyperglycemia significantly by comparing the results obtained with the thermal water and those with the plain water control. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1956-03 |
| 巻 | 17巻 |
| 開始ページ | 8 |
| 終了ページ | 12 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462898 |
| JaLCDOI | 10.18926/40312 |
|---|---|
| タイトル（別表記） | o-PHENANTHROLINE METHOD APPLIED TO THE DETERMINATION OF IRON IN NATURAL WATERS |
| フルテキストURL | pitsr_017_001_007.pdf |
| 著者 | 田中 重男| |
| 抄録 | The o-phenanthroline method was tested as to its applicability to the separate determination of iron in natural water: ionic ferrous iron, reducible iron, snd colloidally dispersed iron. In connection with this, the results of the following experiments are given in this paper. 1. Determination of the absorption curve of o-phenanthroline ferrous complex. (Figure 1.) 2. Construction of the calibration curve for a Purfrich's photometer with filter S 50, 15 cm cuvettes. (Figure 2.) 3. Examination of the effects of coexisting anions on the determination of iron by the method of three way layout. (Table 1., Table 2.) 4. Trial determinations of iron in three different states in solution. (Table 3., Table 4. ) 5. Test of the applicability of this method to the determination of ionic ferrous iron and reducible iron in thermal water. (Table 5., Table 6.) From the above, it was revealed that ionic ferrous iron and reducible iron in natural water are separately determinable with sufficient accuracy by the o-phenanthroline method, and that ionic iron and colloidally dispersed iron are also separately determinable, when the dispersed iron is present in amount more than 1.3% of the total iron. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1956-03 |
| 巻 | 17巻 |
| 開始ページ | 1 |
| 終了ページ | 7 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40311 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462897 |
| JaLCDOI | 10.18926/40273 |
|---|---|
| タイトル（別表記） | On the Underground Temperatures and Radioactivities at One Meter Depth in the Misasa Hot Spring Area |
| フルテキストURL | pitsr_020_055_061.pdf |
| 著者 | 相馬 徳蔵| |
| 抄録 | Methods and Results of Measurements:-- A stick of steel was driven into the ground down to one meter depth, and a narrow pipe of aluminum or brass, closed at the upper end, was inserted and the hole covered by a board and earth. (See Fig.3.) In Fig.2 the locations for the experiments are shown by x. Fig.1 gives the atmospheric temperatures at noon, October4-21,1955, when the experiments were carried out. About three hours after the above setting had been done, the gas in the hole was replaced by a bottle of water, and was collected, by driving sprayer for five minutes with apparatus as shown in Fig.5, in a can in which an autoradiographic plate was set. (See Fig.6.) The temperature in the hole was read by means of a maximum thermometer hung in the hole for ten minutes at one meter depth. Fig.7 shows the distribution of temperatures at one meter depth thus observed. Exactly twenty four hours after the above setting, the autoradiographic plate in the can (a quarter sized Fuji ET-2E plate, 15μ thick, for contact method) was developed. For developing, the plate was immersed in Ilford D-19 for fifteen minutes, then fixed with Fuji-fix for fifteen minutes, washed with running water for forty minutes, and dried. Then those autoradiographic plate was examined under the microscope of magnification ×280, to count the number of tracks of a-particles. The results obtained are shown in Fig.8. Underground Temperature Distribution:-- On the basis of the distribution of temperatures at one meter depth (Fig.7) and of other available boring data, the distribution of undergound temperatures is estimated as shown in Fig.9 (vertical section along the Misasa river). |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-01 |
| 巻 | 20巻 |
| 開始ページ | 55 |
| 終了ページ | 61 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462896 |
| JaLCDOI | 10.18926/40272 |
|---|---|
| タイトル（別表記） | THE CHANGE IN CONCENTRATION OF FERROUS IRON AND REDUCIBLE IRON, DISSOLVED IN SPRING WATER AT MISASA HOT SPRINGS, JAPAN, DURING PRESERVATION OF THE WATER SAMPLE IN A SEALED BOTTLE |
| フルテキストURL | pitsr_020_048_054.pdf |
| 著者 | 田中 重男| |
| 抄録 | The two sprigns called "Tanaka-no-Yu" and "Hisui-no-Yu" at Misasa Hot Springs, japan (Fig. 1), suitable for sampling the unpolluted water, the locations of which, are shown in Fig. 2, were chosen for this study. The o-phenanthroline method, details of which were discussed in the previous report by the author (Repts. Balneol. Lab. Okyama Univ., 17, 1, (1956)) was used for the determination of ferrous iron, ferrous iron + reducible iron, and ferrous iron + reducible iron + colloidally dispersed iron (to be referred to as "total irons" in this report). For comparison, the change in concentratin of iron dissolved in distilled water during preservation in a sealed bottle was observed, and the results obtained for the solutions with the pH values of 5.4 and 5.8 are illustrated in Fig.3 and Fig.5, rspectively. Both ferrous and reducible iron disappear within 5 minutes, when the pH of the solution is 6.4. The hydrogen ion concentration was thus seen to give a sensitive effects on the speed of diminution of ferrous and reducible iron dissolved in the distilled water. It should be noticed that no appreciable diminution was observed during the period from 60 min. to 120 min,. It is probable that the diminution of total iron is caused by the adsorption of colloidal iron hydroxides on the wall of glass bottle. The effects of charged anion (SO(4)(--)) on the change in concentration of iron during preservation was also investigated, but no appreciable effect was found. (Fig. 5 and Fig. 6). Fig.7, Fig.8, and Fig.9 show the change in concentration of iron during preservation of the spring water at "Tanaka-no-Yu". The content of iron in the spring water is about 0.3 mg/l, and its pH value is about 7.1. For the first 30 minutes, ferrous iron diminishes rapidly, the slope of the diminution curve being sharp and almost straight. Thereafter the slope becomes gentler, and, after an hour, the slope approaches nearly zero. On the other hand, ferrous iron dissolved in distilled water disappears in a moment at the same pH 7.1. Fig.10, Fig.11, and Fig.12 show the change in concentration of iron during preservation of the spring water at "Hisui-no-Yu". The content of iron in the spring water is about 1.0 mg/l, and its pH value is about 6.4. In this case, the diminution of ferrous iron is not remarkable, and only 20% of the initial quantity diminishes within 2 days. Whereas, in the case of distilled water, the diminution is very rapid at the same pH 6,4, and the ferrous iron disappears completely within 5 minutes. In Fig.13 the speed of diminution of iron in distilled water and that in spring water are compared. The difference here seen may probably be due either to that the ferrous iron in spring water is in a certain complex form not easily oxidizable, or to that the spring water contains some reducing substances. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-01 |
| 巻 | 20巻 |
| 開始ページ | 48 |
| 終了ページ | 54 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462895 |
| JaLCDOI | 10.18926/40271 |
|---|---|
| フルテキストURL | pitsr_020_042_047.pdf |
| 著者 | 田中 重男| |
| 抄録 | Differential thermal investigation was made of amorphous hydrous ferric oxides, precipitated on neutralization of ferric chloride solution under different laboratory conditions, ranging from DOC to 85°C in temperature, and from 3 to 12 in pH. Each of the differential thermal curves obtained shows an endothermic peak due to the release of adsorbed water, followed by a exothermic peak due to crystallization of anhydrous ferric oxide to hematite. The temperature corresponding to the exothermic peak varies in the range from 240°C to 460°C accrding to the temperatures and pH values of the solution from which the hydrous ferric oxide is precipitated. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-01 |
| 巻 | 20巻 |
| 開始ページ | 42 |
| 終了ページ | 47 |
| ISSN | 0369-7142 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002462894 |
| JaLCDOI | 10.18926/40270 |
|---|---|
| タイトル（別表記） | DIE KLINISCHEN UND EXPERIMENTELLEN UNTERSUCHUNGEN ÜBER DIE PELOIDTHERAPIE BEI GYNÄKOLOGISCHEN ENTZÜNDUNGEN |
| フルテキストURL | 020_001_041.pdf |
| 著者 | 岡田 俊郎| |
| 抄録 | Die resortive Behandlung bei schwerheilbaren chronischen Entzündungen der Adnexe und des Uterus besteht aus verschiedenen Wärmeapplikationsmethoden. Effekt der Peloidtherapie als eine von diesen Methoden wurde untersucht. Die Untersuchung besteht aus klinischer Beobachtung über die Peloidpackung und tier experimentellem Studium über Peloidbad. A) Über die Peloidpackung. 1. Heileffekt der Packung. 35 Fälle, die an chronischer Entzündung der Adnexe und des Uterus gelitten hatten, wurden mit warmer Peloidpackung an Lenden oder Unterbauch täglich einmal für 2 oder 3 Wochen behandelt. Bei den 28 Fällen von diesen 35 Fällen wurde die gute Folge, wie zum Beispiel Nachlass der Schmerzen und der Induration, bemerkt, Da einige Fälle von diesen 28 Fällen schwache Reaktion auf die anderen verschiedenen Therapie wie Ultrakurzwellenbestrahlung gezeigt hatten, Packung mit Peloid muss eine erfolgreichste Therapie in besonderen Fällen sein, 2, Physiologische Untersuchungen über den Einfluss der Packung bei obigen Kranken, Gesteigerte Blutsenkungsgeschwindigkeit normalisierte sich, und Leukozytenzahl zeigte keine Zeichen der Verschlechteung während der Kur, Keine nennenswerte Veränderung des Elektrokardiogramms wurde während und nach Applikation der Peloid gefunden, und bei Kranken mit hohem Blutdruck fiel der Blutdruck vorübergehend während Applikation der Peloid, Steigerung der Hauttemperatur und der Uterustemperatur bei Packung waren grösser als bei Ultrakurzwellenbestrahlung und Heissluftbad, und diese Erscheinungen wurden auch von tierexperimentellen Untersuchungen festgestellt, Ausscheidung der Phenolsulfonphthalein, die in die Bauchhöhle des Kaninchens sich eingespritzt hatte, wurde von Packung an Unterbauch beschleunigt, So stellt diese klinischen und tierexperimentellen Untersuchungen fest, dass Peloidpackung stark resorptiv durch ihre hyperämisierenden Wirkung nach die Tiefe des Krankheitsherdes ist, und zwar es den Kranken zu keiner Last in verschiedenen Seiten fallt, B) Über das Peloidbad, Verfasser hatte ein Stückchen der spongiOsen Gelatine, die üblich als blutstillendes Material bei Operation gebraucht wird, an Peritoneum der Ratten angenäht, und liess diese Ratten die Peloidbäder täglich einmal 20 minutenlang für 4 Wochen nehmen Inzwischen wurden die Ratten wöchentlich getötet, und die spongiöse Gelatine wurde mit umgebener Granulation aus Bauchhöhle herausgenommen, und dann wurde histologisch untersucht. Gleichzeitig wurden Arten der freien Zellen in der Bauchhöhle und die Neutralrotfärbung:::intensität der Hystiozyten in lockerem Bindegewebe der Unterhaut als Merkmal für Abwehrkraft des Organismus untersucht, Es war festgestellt, dass bei Peloidbädern der Verlauf der durch spongiöse Gelatine hervorgerufene Entzündung sich verkürzt, und das Stückchen der Gelatine wird schnell abgesorviert, und zugleich Abwehrkraft sich steigert, Bei diesen Experimente wurden die stark sauere sulfurhaltge Quellenschlamme (Konyajigoku zu Beppu) und die neutrale Schlamme der Seeboden (Toogooike zu Tottoriken) gebraucht, aber kein wesentlicher Wirkungsunterschied zwischen beide Schlamme wurde gefunden. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-01 |
| 巻 | 20巻 |
| 開始ページ | 1 |
| 終了ページ | 41 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532504 |
| JaLCDOI | 10.18926/40268 |
|---|---|
| タイトル（別表記） | The Effect of Early Rising and Spring Bathing after Gastrectomy Operation upon Non-protein-nitrogen Levels in Blood |
| フルテキストURL | 021_047_053.pdf |
| 著者 | 滝川 正| |
| 抄録 | The author investigated variation of non-protein-nitrogen (N-P-N) levels in the blood of patients with gastric ulcer or cancer before and after gastrectomy. The following results were obtained. In the cases of gastric ulcer, N-P-N levels in the blood increased significantly till the 3rd of 4th day after operation, and returned to normalcy within a week in both groups of early rising and thermal bathing, whereas the raised N-P-N levels returned to the former levels in the 2nd week in the control group. In the cases of gastric cancer, in both early rising and thermal bathing groups, N-P-N levels in the blood varied in similar ways as in the cases of gastric ulcer. However, N-P-N in the blood of the control group increased till the 3rd day, and then decreased till the 7th day after operation, but increase was again seen on the 10th day, and then the levels returned to normalcy. From the above findings, the author thinks that early rising and spring bathing after gastrectomy give no bad effect on patients with gastric ulcer and cancer. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-04 |
| 巻 | 21巻 |
| 開始ページ | 47 |
| 終了ページ | 53 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532357 |
| JaLCDOI | 10.18926/40267 |
|---|---|
| タイトル（別表記） | Studies on Balneotherapy of Gynecological Chronic Inflammations |
| フルテキストURL | pitsr_021_001_046.pdf |
| 著者 | 石井 氻| |
| 抄録 | The effects of balneotherapy on gynecological chronic inflammations were examined both clinically and experimentally. Clinical study. Statistical observations were made on the patients with gynecological diseases who visited the spa of Misasa. It was ascertained that, among them, the patients with gynecological chronic inflammati on whose chief complains were hypogastric and Lumbar pains were most common and that, by balneotherapy, their conditions were frequently improved both subjectively and objectively. Experimental study. An experimental foreign body inflammation was evoked by inserting a Sponge into the abdominal cavity of an adult female rat and the effects of hot-spring bath were examined. Acceleration of the absorption of the inflammation, enhancement of phagocytosis of the subcutaneous histiocytes, activation of the fibrohistiocytic system of the subcutaneous connective tissue, and acceleration of return of the free cells in the abdominal cavity were proved. Furthermore, comparative studies were made on the effects of various artificial mineral waters and ultra short waves. It was found that, though they were less effective than natural mineral water, artificial strong saline water, artificial sulfur water, artificial sulfate water, artificial iron water and ultra short waves were effective and that artificial weak saline water, artificial bicarbonate water, artificial humimic acid water, artificial alkaline water, and artificial acidic water were as effective as fresh water. Compared with hot bath, insensible bath was more effective. No significant difference of therapeutic effect was found by bathing once a day or three times a day. In short, balneotherapy had a facilitatory action on the absorption of the inflammatory changes in the abdominal cavity. This should be ascribed not only to the increase in the deep blood flow by warming but also to the general defence mechanism enhanced by cutaneous stimulation. Some differences were also assumed depending on the ions contained in the mineral waters. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-04 |
| 巻 | 21巻 |
| 開始ページ | 1 |
| 終了ページ | 46 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462893 |
| JaLCDOI | 10.18926/40265 |
|---|---|
| タイトル（別表記） | Studies on Paper-Analysis in the Field of Balneology (I) Studies on Iron in Serum by Means of Parper-Electrophoresis and Paper-Chromatography |
| フルテキストURL | 022_037_054.pdf |
| 著者 | 石橋 丸応| |
| 抄録 | 1. The author showed by means of paper-electrophoresis using o-nitrosoresorcinmonomethylether (hereafter N. R. M. E.), a colourdeveloping reagent, that iron in serum combines with β-fraction of serum protein. 2. The author proposed a new method for the determination of serum iron by means of paper-chromatography. Procedure is as follows. In a centriguged tube, 0.5 ml. of clear serum is taken, acidified with 0.15 ml. of 20% HNO(3), and allowed to stand for 20 minutes. After addition of 0.2 ml. of saturated solution of CH(3)COONa and 1 ml. of acetic acid-sodium acetate buffer solution (pH: 3.8), the mixture is kept for at least 10 min. and filtered through Toyo-filter-paper No.5 A. The clear filtrate is taken in a stoppered test tube (the inside diameter: 1.2 cm.; height: 15 cm.). To this filtrate are added 0.2 ml. of 20% Hydroxylamine hydrochloride and 0.25 ml. of saturated aqueous solution of N. R. M. E. After being allowed to stand for at least 20 min., the mixture is shaken with 5 ml. of carbon tebrachloride. Then the excess of N. R. M. E. is removed. The supernatant aqueous solution (0.2 ml.) is used for a determination sample. The sample is placed on the paper (Toyo,filter-paper No.51 or 50) in a thin line at a distance of 10 cm. from the edge, and the spots are developed with 90 % ethylalcohol. After development for 4-6 hours, a green-coloured linear spot appsars at a distance of 12-16 cm. from the origin-point. Spot intensity at 670 mμ is measured with Natsume's densitometer, and from this, concentration of Fe can be estimat.ed on the standard graph (Fig. 5). 3, Effects of radioactive thermal spring bathing and internal use of vitriol water upon serum iron levels were studied with the result.s as follows. The above-mentioned author's method of determining the iron level in a small amount of serum is very convenient in investigating iron metabolism in the field of balneotherapy. The author examined changes of iron levels in serum after radioactive thermal bathing as well as after internal use of acid vitriol water. a) The iron levels in serum were maasurecl by the author's method before and 5, 30 and 60 minutes after the radioactive thermal bath (Rn-content: 10-30 Mache, 42-3°C., for 10 min,). The iron levels in the serum of healthy subjects showed no significant change after the thermal bathing. b) Yanahara Mineral Water (an acid vitriol water, pH; 2.2) contains 0.045 gm. of Cl(-), 12.35 gm. of SO(4)(--), 2.5 gm. of Fe(++)+Fe(+++), 0.0938 gm. of Al(+++) and 0.0001 gm. of Cobalt in one liter. i) Thirty ml. of Yanahara, water diluted with plain water to 200 ml. (Fe(++) content: ca. 75 mg.) and administered to health fasting subjects orally. As a control matter, 0.65 gm. of Glukon-F powder (Fe(++) content.: ca. 75 mg.) was then given. Blood samples were taken from the cubital vein before and 1, 3 and 6 hours after the intake of the dtriol water. Iron contents of the serum samples were measured by the author's paper chromatographic method. The results were shown in the table and the figure. The iron contents of the serum after the intake of the mineral water were higher than in the case of the control. ii) Two ml. of Yanahara vitriol water was administered to rabbits with the aid of a stomach tube, and serum iron levels wera determined before and 1, 3, 4 and 6 hours after the administration. An amount of 0.05 gm. of Glukon-F powder was dissolved in 5 ml. of plain water, and this solution was given to rabbits as a control. After the internal use of vitriol water, iron levels in serum rose and remained unexpactedly high for about 1-4 hours, in a manner that did not. correspond to the amount of iron in the given mineral water. So that it was suspected that the iron originally contained in the living subjects had been mobilized by the intake of vitriol water. Iron levels in serum after administration of a solution of Glukon-F powder were lower than in the case of the mineral water. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-07 |
| 巻 | 22巻 |
| 開始ページ | 37 |
| 終了ページ | 54 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40263 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532359 |
| JaLCDOI | 10.18926/40264 |
|---|---|
| タイトル（別表記） | Clinical and Experimental Studies of Therapeutic Effects of Radioactive Thermal Bath on Peripheric Disorders of Circulation Part 1 The Effect of Radioactive Thermal Bath upon Serum Cholesterol Levels |
| フルテキストURL | 022_001_036.pdf |
| 著者 | 松本 欣之| |
| 抄録 | The author investigated the effect of radioactive hot spring bath on serum cholesterol levels. The chemical compositions of the spring waters used are described in Table I. As experimental subjects healthy men and healthy white rabbits were used. The following results were obtained. 1) Single bath. The total and ester cholesterol levels in the serum were measured by a modification of Bloor's method before and 1/2, 1, 2 and 3 hours after the radioactive thermal bath (41-43°C., for 5 minutes). The concentration of total and ester cholesterol had decreased following radioactive thermal baths (Hisui-no-Yu and Kenkyusho-Sen), and remained at a decreased level for l/2 to 2 hours, but tended to return to normalcy within three hours from the time of the bath. (Fig. 2, 3, 4, 5.) The plain-water bath and vapour bath used as a control (41-43°C., for 5 minutes and 44-47°C. for 10-20 minutes respectively), had no significant effect on the blood cholesterol levels (Fig. 7 and 8). 2) Series of baths. The author examined weekly for 4 weeks the changes in serum cholesterol in healthy subjects following "a series of baths" in radioactive hot springs. The total and ester cholesterol levels of the serum decreased during the first and second weeks and tended to return to the initial levels during the third and fourth weeks (Fig. 11). The total cholesterol levels of the serum in rabbits following "a series of baths" in KenkyushoSen (Rn-content; 10-40 Mache) increased during the second week, but the cholesterol levels of the serum, after bathing in Hisui-no-Yu (Rn-content: 300-400 Mache), tended to decrease during the first and second weeks (Fig. 9 and 10). From this experiment, it is concluded that the content of radon in hot spring water affects the concentrations of the serum cholesterol levels. 3) Following an intramuscular injection of A. C. T. H. or Cortisone, the concentrations of total cholesterol and ester cholesterol had decreased and remained at the low level for 4 hours (Fig. 12. 13, 14 and 15). 4) It is said that the reticulo-endotherial system plays an important part in cholesterol metabolism. The author injectt 5 ml. of 1% Indian ink into the aureal vein of the rabbits for the purpose of blocking the reticulo-endotherial system. These procedures were carried out once a day for 7 successive days. The total cholesterol levels of the serum in the bathed group (bathing in Kenkyusho-sen once a day for 4 weeks, 43°C., 5 minntes) were lower than those of the control (Fig. 16). From these findings, the author thinks that the fall in the serum cholesterol levels following Misasa Hot spring bathing is due to the synthetic action of many factors such as the acceleration of oxydation in the living body, and the hyperfunction of liver cells, of hypophysealadrenocortical, of reticulo-endotherial systems and of various endocrine glands, caused by radioactive thermal bathing. Alternation of vegetative nervous system and various vitamine metabolism also take part in this phenomenon. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-07 |
| 巻 | 22巻 |
| 開始ページ | 1 |
| 終了ページ | 36 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40263 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532360 |
| JaLCDOI | 10.18926/40261 |
|---|---|
| タイトル（別表記） | Clinical and Experimental Studies of Therapeutic Effects of Radioactive Thermal Bath on Peripheric Disorders of Circulation Part 3. Therapeutic Effects of Radioactive Thermal Bath on Hypercholesterolemia and Atherosclerosis |
| 著者 | 松本 欣之| |
| 抄録 | The author investigated the changes of serum cholesterol levels and the histological findings of aorta of the cholesterol-fed rabbits, and the changes of serum cholesterol levels of the patients with hypertension following the radioactive hot spring bathing. The following results were obtained: 1) When 0.2 g. of cholesterol per Kg. of bodyweight was given to rabbits one time, the rise of the concentrations of serum cholesterol in the bathing group was lower and the recovery to the initial levels in the same group was faster than in the case of control (Table 1, Fig. 1.). 2) The author gave the rabbits 0.15 g. of cholesteterol per Kg. of bodyweight daily for 4 weeks. In this experiment, these rabbits were divided into 4 groups at follows. Group 1 Rabbits of this group were not bathed (as control). Group 2 Rabbits of this group were bathed in plain water (43°±1°C. 10 minutes) daily for 4 weeks. Group 3 Rabbits of this group were bathed in the radioactive Kenkyu-sho-sen (Rn-content: 10-40 Mache) in the same way as group 2. Group 4 Rabbits of this group were bathed in the radioactive Hisui-no-Yu (Rncontent: 300-400 Mache) in the same way as group 2. The concentrations of the serum cholesterol of the groups of radioactive thermal bathing remained lower than the control group. The concentrations of the serum cholesterol of group 4 were the lowest of all (Table 2 and Fig. 2). 3) In radioactive bathing groups, the atherosclerotic changes of aorta of the cholesterol-fed rabbits were slighter than the control (Table 3 and Fig, 3). 4) Following a series of radioactive hot spring baths, the total and ester cholesterol levels in serum of the patients with hypertension decreased during the first and the second weeks and tended to return to the initial levels during the third and the fourth weeks (Table 4 and Fig. 4). 5) The author gave the rabbits 0.4 g, of cholesterol per Kg. of bodyweight and, 2 hours after this procedure, injected 5 mI. of 1% Indian ink into the aureal vein of the rabbit for the purpose of blocking the reticulo-endothelial system. These procedures were carried out once a day for 3 successive days. The serum total and ester cholesterol levels in the bathed group (bathing in Hisui-no-Yu once a day for 15 days, 42±1°C, 5 minutes) were lower those of the control and returned to initial levels more rapidly than the control (Table 5 and Fig. 5). |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-10 |
| 巻 | 23巻 |
| 開始ページ | 38 |
| 終了ページ | 58 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40258 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532363 |
| JaLCDOI | 10.18926/40260 |
|---|---|
| タイトル（別表記） | Clinical and Experimental Studies of Therapeutic Effects of Radioactive Thermal Bath on Peripheric Disorders of Circulation Part 2. The Effect of Radioactive Thermal Bath upon Organ Cholesterol Levels |
| フルテキストURL | pitsr_023_023_037.pdf |
| 著者 | 松本 欣之| |
| 抄録 | The author investigated the effect of radioactive hot spring bath on various organ cholesterol levels. As experimental subjects white male rat weighing ca. 150 g. were used. The total cholesterol of the lungs, liver, heart, kidneys and brain, and the total and ester cholesterol of the adrenals were measured by a modification of Bloor's method. The following results were obtained: 1) Single bath: The concentration of the total cholesterol of these organs and the ester cholesterol of adrenals decreased for two hours after a radioactive "Hisui-no-Yu" bath, but such decrease was recognised only in the heart, brain, adrenals after a weak radioactive "Kenkyusho-sen". 2) A series of baths: The concentration of the total cholesterol of the lungs, heart, brain, adrenals and the ester cholesterol of adrenals decreased after a series of "Hisui-no-Yu" baths for 4 weeks. 3) A series of baths in cholesterol fed rats: The concentration of the total cholesterol of the above mentioned organs and the ester cholesterol of the adrenals in the bathing group remained decreased during the experiment comparing with the control group. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-10 |
| 巻 | 23巻 |
| 開始ページ | 23 |
| 終了ページ | 37 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40258 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462892 |
| JaLCDOI | 10.18926/40259 |
|---|---|
| タイトル（別表記） | Study of Togo -Matsuzaki Hot Springs, Tottori Prefecture |
| フルテキストURL | pitsr_023_001_022.pdf |
| 著者 | 梅本 春次| 原田 光| 岡部 茂| 宮腰 潤一郎| 阪上 正信| 田中 昌也| 御船 政明| |
| 抄録 | 1. Layers containing thermal water in this district are thin, and lie at different depths (about 35, 55, and 60 meters) from the ground surface. There are evidences to show that these layers are intimately connected with one another. 2. The authors may suppose the existence of a structurally weak zone, along the line from Matsuzaki to Asozu, within which the issuing spots of thermal springs are located. 3. The head water levels of the thermal springs in this district are closely related with that of Lake Togo. Keeping pace with the variations of the water levels of Lake Togo and of artesian wells in its vicinity, the rate of flow of thermal springs vary; and the correlation between these variations is apparent. 4. The pumping suction of thermal water at one spring affects the flow of water at other springs within distances of 150 to 200 meters therefrom, though the direct sources of thermal water supply for the latter springs may be different from that of the former. 5. The spring water in this district is considered to be a mixture of hot water, containing sodium, calcium, chloride, and sulfate ions, and cold water, containing bicarbonate ion. The diversity of chemical constitutions of different spring waters is explained as due to the difference in proportion in which the hot and cold waters are mixed. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1958-10 |
| 巻 | 23巻 |
| 開始ページ | 1 |
| 終了ページ | 22 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/40258 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002462891 |